JPH11510823A - チロシンキナーゼ阻害剤としての置換キノリルメチレン−オキシインドール類似体 - Google Patents
チロシンキナーゼ阻害剤としての置換キノリルメチレン−オキシインドール類似体Info
- Publication number
- JPH11510823A JPH11510823A JP10500166A JP50016698A JPH11510823A JP H11510823 A JPH11510823 A JP H11510823A JP 10500166 A JP10500166 A JP 10500166A JP 50016698 A JP50016698 A JP 50016698A JP H11510823 A JPH11510823 A JP H11510823A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- oxindole
- compound
- group
- nhr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9611797.3 | 1996-06-06 | ||
| GBGB9611797.3A GB9611797D0 (en) | 1996-06-06 | 1996-06-06 | Substituted quinolylmethylen-oxindole analogues as tyrosine kinase inhibitors |
| PCT/EP1997/002673 WO1997046551A1 (fr) | 1996-06-06 | 1997-05-15 | Analogues de quinolylmethylen-oxindole substitues en tant qu'inhibiteurs des tyrosines kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH11510823A true JPH11510823A (ja) | 1999-09-21 |
Family
ID=10794814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10500166A Ceased JPH11510823A (ja) | 1996-06-06 | 1997-05-15 | チロシンキナーゼ阻害剤としての置換キノリルメチレン−オキシインドール類似体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5905149A (fr) |
| EP (1) | EP0876365A1 (fr) |
| JP (1) | JPH11510823A (fr) |
| GB (1) | GB9611797D0 (fr) |
| WO (1) | WO1997046551A1 (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6133305A (en) * | 1997-09-26 | 2000-10-17 | Sugen, Inc. | 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity |
| ES2192877T3 (es) * | 1998-12-17 | 2003-10-16 | Hoffmann La Roche | 4-alquenil (y alquinil) oxindoles como inhibidores de kinasas ciclina-dependientes, en particular cdk2. |
| BR9916324A (pt) | 1998-12-17 | 2001-10-02 | Hoffmann La Roche | 4,5-pirazinoxindóis como inibidores de proteìna quinase |
| US6153634A (en) | 1998-12-17 | 2000-11-28 | Hoffmann-La Roche Inc. | 4,5-azolo-oxindoles |
| KR20010101266A (ko) | 1998-12-17 | 2001-11-14 | 프리돌린 클라우스너, 롤란드 비. 보레르 | Ｊｎｋ 단백질 키나제의 억제제로서의 4-아릴옥신돌 |
| US6313310B1 (en) | 1999-12-15 | 2001-11-06 | Hoffmann-La Roche Inc. | 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles |
| DK1255536T3 (da) * | 1999-12-22 | 2006-10-30 | Sugen Inc | Indolinonderivater til modulation af c-kit-tyrosinproteinkinase |
| US6339100B1 (en) | 1999-12-29 | 2002-01-15 | The Trustees Of Columbia University In The City Of New York | Methods for inhibiting mastocytosis |
| US6797825B2 (en) | 2001-12-13 | 2004-09-28 | Abbott Laboratories | Protein kinase inhibitors |
| US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| JP4937881B2 (ja) | 2006-11-01 | 2012-05-23 | 財団法人工業技術研究院 | アズレン化合物 |
| CN103896965B (zh) * | 2012-12-27 | 2016-02-24 | 华东理工大学 | 杂环取代苯乙烯类化合物及其用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9004483D0 (en) * | 1990-02-28 | 1990-04-25 | Erba Carlo Spa | New aryl-and heteroarylethenylene derivatives and process for their preparation |
| GB9313638D0 (en) * | 1993-07-01 | 1993-08-18 | Erba Carlo Spa | Arylidene and heteroarylidene oxindole derivatives and process for their preparation |
| GB9326136D0 (en) * | 1993-12-22 | 1994-02-23 | Erba Carlo Spa | Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents |
| GB9423997D0 (en) * | 1994-11-28 | 1995-01-11 | Erba Carlo Spa | Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation |
| GB9501567D0 (en) * | 1995-01-26 | 1995-03-15 | Pharmacia Spa | Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors |
-
1996
- 1996-06-06 GB GBGB9611797.3A patent/GB9611797D0/en active Pending
-
1997
- 1997-05-15 WO PCT/EP1997/002673 patent/WO1997046551A1/fr not_active Application Discontinuation
- 1997-05-15 JP JP10500166A patent/JPH11510823A/ja not_active Ceased
- 1997-05-15 EP EP97927035A patent/EP0876365A1/fr not_active Withdrawn
- 1997-05-15 US US08/983,516 patent/US5905149A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997046551A1 (fr) | 1997-12-11 |
| GB9611797D0 (en) | 1996-08-07 |
| EP0876365A1 (fr) | 1998-11-11 |
| US5905149A (en) | 1999-05-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20040401 |
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| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20070828 |
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| A72 | Notification of change in name of applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A721 Effective date: 20071005 |
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| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20071121 |
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| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20080111 |
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| A313 | Final decision of rejection without a dissenting response from the applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A313 Effective date: 20080424 |
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| A02 | Decision of refusal |
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