JPH11505507A - 組換えヒルジンまたは表皮増殖因子のようなタンパク質の折りたたみ方法 - Google Patents
組換えヒルジンまたは表皮増殖因子のようなタンパク質の折りたたみ方法Info
- Publication number
- JPH11505507A JPH11505507A JP8505402A JP50540295A JPH11505507A JP H11505507 A JPH11505507 A JP H11505507A JP 8505402 A JP8505402 A JP 8505402A JP 50540295 A JP50540295 A JP 50540295A JP H11505507 A JPH11505507 A JP H11505507A
- Authority
- JP
- Japan
- Prior art keywords
- protein
- proteins
- hirudin
- correctly folded
- separation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 71
- 238000000034 method Methods 0.000 title claims abstract description 36
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94810437 | 1994-07-25 | ||
| DE94810437.7 | 1994-07-25 | ||
| PCT/EP1995/002720 WO1996003425A1 (fr) | 1994-07-25 | 1995-07-12 | Procede de repliement de proteines telles que l'hirudine ou le facteur de croissance epidermique de recombinaison |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH11505507A true JPH11505507A (ja) | 1999-05-21 |
Family
ID=8218291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8505402A Pending JPH11505507A (ja) | 1994-07-25 | 1995-07-12 | 組換えヒルジンまたは表皮増殖因子のようなタンパク質の折りたたみ方法 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0804461A1 (fr) |
| JP (1) | JPH11505507A (fr) |
| AU (1) | AU3109795A (fr) |
| CA (1) | CA2194177A1 (fr) |
| FI (1) | FI970230A (fr) |
| IL (1) | IL114699A0 (fr) |
| NO (1) | NO970081D0 (fr) |
| WO (1) | WO1996003425A1 (fr) |
| ZA (1) | ZA956137B (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3734634B2 (ja) * | 1999-03-03 | 2006-01-11 | ヒゲタ醤油株式会社 | タンパク質の活性化方法及び該装置 |
| US7521479B2 (en) | 2001-04-16 | 2009-04-21 | Panacea Pharmaceuticals, Inc. | Methods of treating prion disease in mammals |
| WO2003097669A2 (fr) * | 2002-05-17 | 2003-11-27 | Københavns Universitet | Procede de purification de proteines denaturees presentant une configuration de liaisons de disulfide voulue |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR79124B (fr) * | 1982-12-22 | 1984-10-02 | Genentech Inc | |
| ES8800957A1 (es) * | 1985-02-22 | 1987-12-01 | Monsanto Co | Un metodo para la solubilizacion y renaturalizacion de proteina somatotropina |
| GB8927546D0 (en) * | 1989-12-06 | 1990-02-07 | Ciba Geigy | Process for the production of biologically active tgf-beta |
| WO1992014832A1 (fr) * | 1991-02-26 | 1992-09-03 | Ajinomoto Co., Inc. | Procedes pour la purification de fdlb humains |
| US5290920A (en) * | 1992-04-16 | 1994-03-01 | Allelix Biopharmaceuticals Inc. | Method of purifying human epidermal growth factor |
-
1995
- 1995-07-12 JP JP8505402A patent/JPH11505507A/ja active Pending
- 1995-07-12 CA CA002194177A patent/CA2194177A1/fr not_active Abandoned
- 1995-07-12 AU AU31097/95A patent/AU3109795A/en not_active Abandoned
- 1995-07-12 WO PCT/EP1995/002720 patent/WO1996003425A1/fr not_active Application Discontinuation
- 1995-07-12 EP EP95926859A patent/EP0804461A1/fr not_active Withdrawn
- 1995-07-24 IL IL11469995A patent/IL114699A0/xx unknown
- 1995-07-24 ZA ZA956137A patent/ZA956137B/xx unknown
-
1997
- 1997-01-09 NO NO970081A patent/NO970081D0/no unknown
- 1997-01-20 FI FI970230A patent/FI970230A/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO970081L (no) | 1997-01-09 |
| FI970230A0 (fi) | 1997-01-20 |
| EP0804461A1 (fr) | 1997-11-05 |
| CA2194177A1 (fr) | 1996-02-08 |
| FI970230A (fi) | 1997-01-20 |
| NO970081D0 (no) | 1997-01-09 |
| AU3109795A (en) | 1996-02-22 |
| WO1996003425A1 (fr) | 1996-02-08 |
| IL114699A0 (en) | 1995-11-27 |
| ZA956137B (en) | 1996-03-07 |
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