JPH1149686A - Blue bruise skin lotion - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a blue bruise skin lotion not only having an excellent blue bruise-deleting effect but also excellent in safety, usability, profitability, etc., by compounding an ingredient originated from a plant and having specific actions. SOLUTION: This skin lotion use contains a plant-originated ingredient having both a blood circulation-stimulating action and an anti-inflammatory action, or a plant-originated ingredient having a blood circulation-stimulating action and an ingredient having an anti-inflammatory action. The plant-originated ingredient having both the blood circulation-stimulating action and the anti- inflammatory action is preferably a Coleus extract, arnica, melissa oil, ginger extract, Swertia japonica extract, cinnamon extract, ginger oil, etc. The plant- originated ingredient having the blood circulation-stimulating action is especially Japanese pepper, bardanae fructus, etc., and the compound having the anti- inflammatory action is especially preferably horse chestnut, Phellodendron Bark, Eriobotrya japonica, Myrica rubra, Rehmannia glutinosa, Cinnamomum camphora, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for blue bruise, which has not only an excellent blue bruising effect but also excellent safety, usability and economy.

[0002]

2. Description of the Related Art
As a preparation for treating blue bruise, a heparin-containing preparation containing heparin as an active ingredient is known. However, in the case of heparin-containing preparations, there are concerns about side effects when frequently used or when used in large quantities, and heparin has an anticoagulant effect, so it cannot be applied to blue bruises with trauma or bleeding. There are usage restrictions,
There has been a demand for the development of a preparation for the treatment of blue bruise, which replaces the preparation containing heparins. Furthermore, since heparins are derived from living organisms, improvement in their price, convenience in obtaining, and the like has been desired.

[0003] The present invention has been made to meet the above-mentioned demands, has an excellent blue bruise eliminating effect, is excellent in safety, and can eliminate use restrictions such as a preparation containing heparin. It is an object of the present invention to provide a skin external preparation for blue bruise which is excellent in economy, convenience of acquisition, and the like.

[0004]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies in order to achieve the above object, and as a result, as an active ingredient against blue bruise, there are fewer side effects than heparins, and the availability is not so high. Focusing on easy and inexpensive plant-derived components that have blood circulation-promoting action, etc., and further diligent studies have revealed that blue bruise is effective only when the two actions of blood circulation promotion and anti-inflammatory are combined. By using a plant-derived component having not only a blood circulation promoting action but also an anti-inflammatory action, or a plant-derived component having only a blood circulation promoting action and a plant-derived component having an anti-inflammatory action, a compound The present inventors have found that the blue bruise eliminating effect is clearly expressed by combining the above and the like to exert the above two effects, and have completed the present invention.

[0005] That is, the present inventors promote the treatment of blue bruises.
When the mechanism of onset and the mechanism of treatment were examined in detail in order to achieve improvement, the following was confirmed.

That is, blue bruise is medically a "hematoma after trauma", and more specifically, a blood component (plasma) exuded between tissue cells by rupture of capillaries in skin or subcutaneous tissue due to external force. , Red blood cells, platelets, etc.), which are referred to as "blue bruises" because the signs of subcutaneous hemorrhage appear bluish dark red in appearance.
In addition, the blue bruise is always characterized by swelling, pain, redness, fever, etc., accompanied by the above-mentioned rupture of blood vessels and exudation of blood components between tissue cells, and usually causes inflammation which has a tissue dysfunction. . Such inflammation begins immediately after tissue damage, peaks in the first few days, and then gradually disappears with repair of blood vessels and tissues and elimination of exudates.

[0007] Based on the above onset mechanism and therapeutic mechanism,
In the treatment of blue bruise, the present inventors initially suppressed the elevation of inflammatory features such as swelling, pain, redness, and fever by an anti-inflammatory effect, and while these were suppressed, blood vessels and
It is effective to promote the natural healing of tissue repair, and subsequently to actively remove exudates by the action of promoting blood circulation, thus promoting the blood circulation (increase of blood flow) for the treatment effect of blue bruise.
It was concluded that healing effect in the initial stage was insufficient with only the above, and that treatment and resolution of blue bruise could be achieved for the first time by the two actions of blood circulation promotion and anti-inflammatory as described above.

[0008] Accordingly, the present invention provides a skin external preparation for blue bruise characterized by comprising a plant-derived component having both a blood circulation promoting action and an anti-inflammatory action, and a plant-derived component having a blood circulation promoting action and an anti-inflammatory action. Provided is a skin external preparation for blue bruises, characterized by being used in combination with a component having an action.

Hereinafter, the present invention will be described in more detail. The topical skin preparation for blue bruises of the present invention comprises a plant-derived component having both a blood circulation promoting action and an anti-inflammatory action, or a plant-derived component having a blood circulation promoting action and an anti-inflammatory composition. By containing a component having an action, it has two actions of blood circulation promotion and anti-inflammatory. Here, the form of the plant-derived component of the present invention is not particularly limited, and for example, a liquid, a paste, a solid, a dried product, and the like can be used.

[0010] The plant-derived component of the present invention having both a blood circulation-promoting action and an anti-inflammatory action is not particularly limited in its kind. For example, a component extracted from the genus Coleus, a component extracted from the genus Arnica, Melissa In addition to components extracted from the genus, components extracted from plants classified into other genera and the like are suitably used.Specifically, as components derived from the genus Coleus, Coleus extract, etc., derived from the genus Arnica Ingredients derived from the genus Melissa, such as Arnica tincture, Melissa oil, and other components derived from other genera, such as ginger extract, assembly extract, cinnamon extract, clove oil, spearmint oil, cardamom oil, eucalyptus oil, and touki extract , Peony extract, fennel extract, gongon extract, etc.
These can be used alone or in combination of two or more. Among them, coleus extract, arnica tincture, melissa oil, ginger extract, assembly extract, cinnamon extract, clove oil, spearmint oil, cardamom oil, eucalyptus oil and the like are particularly effective. In the case of the present invention, these plant-derived components can also be used as plant-derived components having a blood circulation promoting action or components having an anti-inflammatory action as described in detail below.

Examples of the plant-derived component having a blood circulation promoting effect include, in addition to the above-mentioned plant-derived component having an anti-inflammatory effect, an extract from the genus Coleus, such as Sayabana, an extract from the genus Arnica, such as rabbit, and mint. Extract from Melissa spp., Periwinkle, rosemary,
Extracts from other genera such as hawthorn, lavender, garlic, capsicum, safflower, fennel, Korean ginseng, chisseng carrot, spinach, ginseng, chamomile, touyaku, sansho, goboushi, kujin, ginkgo, etc. can be mentioned. These may be used alone or 2
More than one species can be used in appropriate combination. Among them, extracts from salamander, burdock, kujin and the like are particularly effective.

The component having an anti-inflammatory effect used in combination with these plant-derived components having a blood circulation promoting action may be of plant origin or other compounds such as compounds. As the derived component, in addition to those having the above-mentioned blood circulation promoting action, for example, bayberry, horse chestnut, sicon, dirt, oak, buttonpi,
Examples of extracts and compounds from soybean, camphor, psycho, loquat, scallop and the like include, for example, azulene, proxycam, bufexamac, ketoprofen, camphor, glycyrrhetinic acid, and the like. These may be used alone or in combination of two or more. Can be used in appropriate combination. Considering side effects and safety among these,
Plant-derived components are more preferred, and extracts from horse chestnut, oak, loquat, bayberry, giant ginkgo, camphor tree, botanical tree, and the like are particularly effective.

The amount of each of the above-mentioned plant-derived components and the component having an anti-inflammatory effect in the topical skin preparation for blue bruises of the present invention is not particularly limited.
In view of the purpose of the present invention, the blood circulation promoting action of each component, is a sufficient amount to exhibit an anti-inflammatory effect, the plant-derived component having both a blood circulation promoting action and an anti-inflammatory action, the entire external preparation In contrast, the content is preferably 0.001 to 30% (% by weight, the same applies hereinafter), preferably 0.005 to 10%, and more preferably 0.01 to 5%. If the amount is too small, the blue bruising effect may not be sufficiently obtained,
If the amount is too large, formulation may be difficult or uneconomical.

When a plant-derived component having a blood circulation promoting action and a component having an anti-inflammatory effect are used in combination, the plant-derived component having a blood circulation promoting action is 0.001 to 0.003% for the same external preparation as above. 30%, preferably 0.00
The content is preferably 5 to 10%, more preferably 0.01 to 5%, and the component having an anti-inflammatory action is 0.001 to 30%.
%, Preferably 0.005 to 10%, more preferably 0.01 to 5%. Also, in this case,
The total amount of the plant-derived component having a blood circulation promoting action and the component having an anti-inflammatory action is 0.1% with respect to the whole external preparation.
001 to 50%, preferably 0.01 to 20%, more preferably 0.01 to 10%, and the compounding ratio of a plant-derived component having a blood circulation promoting action and a component having an anti-inflammatory action is: Plant-derived component having blood circulation promoting action:
Component having anti-inflammatory action (weight ratio) = 1: 19-19:
1, preferably 1: 9 to 9: 1, more preferably 3: 7
７7: 3 is preferable. Other than the above mixing ratio,
There is a case where the blue bruising effect cannot be sufficiently obtained.

The skin external preparation for blue bruises of the present invention may contain compounds having a blood circulation promoting action other than the above-mentioned plant-derived components, as long as the effects of the present invention are not impaired. Heparins, tocopherol acetate, nicotinamide, minoxidil, mononitroguaiacol, pantothenic acid and the like can be mentioned, and these can be used alone or in appropriate combination of two or more kinds. The effective amount can be set as long as the effect of the invention is not hindered.

The skin external preparation for blue bruise of the present invention includes:
As long as the effects of the present invention are not impaired, surfactants, adhesives, blood circulation promoting, anti-inflammatory actions other than the above-mentioned ingredients, if necessary, which are added to ordinary drugs, quasi-drugs, cosmetics, etc. , A humectant, a fragrance, a pigment, a pigment, a crosslinking agent, a pH adjuster, a softening agent, a preservative, a lubricant, a solvent, and the like having the above. Specifically, examples of the surfactant include alkyl allyl polyether alcohol, self-emulsifying glyceryl monostearate, sucrose fatty acid ester, stearyl alcohol, sorbitan cetanol sesquioleate, sorbitan fatty acid ester, and polyoxyethylene hydrogenated castor oil 20. , Polyoxyethylene stearyl ether, polyoxyethylene (105) polyoxypropylene (5) glycol, polyoxyethylene (120) polyoxypropylene (40) glycol, polysorbate, macrogol 400, sorbitan monooleate, lauromacrogol, etc. As an adhesive, for example, acrylic acid / octyl acrylate copolymer, gum arabic, sodium alginate, lanolin hydrolyzate, carboxyvinyl polymer, carmellose , Carmellose sodium, glycerin, styrene-isoprene-styrene block copolymer, gelatin, tragacanth, white petrolatum, hydroxypropylcellulose, hydroxypropylmethylcellulose 2208, propylene glycol, polyacrylic acid, sodium polyacrylate, polyacrylic acid Japanese product, polyvinyl alcohol (partially saponified product), methacrylic acid / acrylic acid n-
Butyl copolymer, methylpolysiloxane, xanthan gum, light silicic anhydride, purified lanolin, cetanol, dextrin, palmitic acid, hydroxypropylmethylcellulose 2910, castor oil, polyvinylpyrrolidone K90, macrogol 6000, methylcellulose, liquid paraffin, etc. As a medicinal ingredient having an action other than the inflammatory action, for example, various analgesics, antipruritics, vitamins, bactericides and the like usually blended in an external preparation for skin, and as a humectant, for example, D-sorbitol, urea, glycerin,
Examples of flavoring agents such as hyaluronic acid salts, glycols, macrogol, etc. include orange oil, camphor, mint, menthol, geraniol, spearmint, cherry flavor, lemon oil, pine oil, and other fruit oils.
As the pigments and pigments such as flavor, green tea powder, bergamot oil, and rose oil, those effective in masking blue bruises and those that enhance palatability are suitable. For example, yellow iron oxide, yellow iron sesquioxide, oxide Titanium, copper chlorophyllin sodium, phenol red, red bengalane, methylene blue, riboflavin, carotene, various other food colorings, foundation pigments, etc. As crosslinking agents, for example, magnesium aluminate silicate, magnesium hydroxide alumina, magnesium aluminate metasilicate, synthesis Examples of pH adjusters such as hydrotalcite, dihydroxyaluminum aminoacetate, aluminum silicate, magnesium oxide, potassium alum, calcium chloride, and the like, for example, citric acid, succinic acid, acetic acid, tartaric acid, boric acid, phosphoric acid,
Maleic acid and salts thereof, dihydrogen phosphate, hydroxide salt, trialkylolamine, etc., as softeners and preservatives, for example, sodium benzoate, benzalkonium chloride, benzethonium chloride, chlorhexidine hydrochloride, salicylic acid, sorbin Potassium acid, thimerosal, thymol, boric acid, alkyl parahydroxybenzoate, etc. as lubricants, such as carnauba wax, hydrated silicon dioxide, sucrose fatty acid ester, silicone resin, magnesium stearate, cetal, talc, etc .; Glycerin, squalane, wax, ethyl acetate, purified water, castor oil, coconut oil, isopropyl palmitate, etc., and their blending amounts do not hinder the effects of the present invention. Normal dose within the range It is possible.

The formulation for the external preparation for blue bruise of the present invention is not particularly limited in the form thereof, and examples thereof include packs, creams, emulsions, foundations, cataplasms, aerosols,
Lotions, film preparations, sheet preparations and the like can be prepared, and the preparation method for preparing these preparations is not particularly limited. It can be prepared by a conventional method of a mold.

The skin external preparation for blue bruise of the present invention is not particularly limited in the physical properties of the preparation, as long as the effects of the present invention, the normal usability of each preparation, the safety and stability of the preparation are not impaired. The physical properties can be appropriately selected.

The amount and usage of the external preparation for blue bruise of the present invention are not particularly limited, and can be appropriately selected depending on the above-mentioned dosage forms. For example, the dosage form of the external preparation for skin can be applied to the skin. If it is used, take the appropriate amount of the external preparation for skin according to the size of the blue bruise, apply it to fingers or cut cotton, etc., and apply it to the application site about 1 to 6 times a day until the blue bruise disappears. An application method can be mentioned. In addition, the usage of the external preparation for skin of the present invention is not particularly limited as described above, and can be used in the usual usage of each dosage form, but the purpose of the present invention to eliminate blue bruises can be used. In consideration of this, it is desirable to avoid rubbing the external preparation for blue bruises of the present invention on the application site or using it to massage the application site.

As described above, according to the external preparation for blue bruise of the present invention, not only can an external preparation exhibiting an excellent blue bruise eliminating effect be obtained by its blood circulation promoting action and anti-inflammatory action. It can also be used for blue bruises with trauma and bleeding. In addition, since the active ingredient is a plant-derived ingredient or is mainly composed of a plant-derived ingredient, it is excellent in safety and has a biological origin such as heparin. It is easily available and inexpensive.

[0021]

Industrial Applicability The external preparation for blue bruise of the present invention has an excellent blue bruise repellent effect, has no use restrictions such as a preparation containing heparin, and is safe, economical, and easily available. It is also useful as an external preparation for skin for treating blue bruise and treating blue bruise.

[0022]

EXAMPLES Hereinafter, the present invention will be described specifically with reference to Experimental Examples, Examples and Comparative Examples, but the present invention is not limited to the following Examples.

[Experimental Example] Carrageenan edema inhibition test described below was carried out to confirm a plant-derived component having an anti-inflammatory effect from the plant-derived components listed in Table 1 which are known to have a blood circulation promoting effect. The presence or absence of an inflammatory effect was confirmed. The results are also shown in Table 1. <Carrageenin edema inhibition test> 1 rat (ラ ッ ト, 4 weeks old)
Eight groups were divided into a sample (plant-derived component) -treated group and a sample-untreated group, and the hind limb foot heel (foot edema was induced 4 hours and 2 hours before the rats in the sample-treated group induced paw edema. 0.1 g of the specimen was applied to each of the parts to be subjected to the treatment.

Next, 0.1 ml of a 1% aqueous carrageenan solution was administered to each rat subcutaneously in the hind limbs of the rats in the sample-treated group and the sample-untreated group to induce paw edema. After that, the foot volume of the hind limb was measured every hour until 6 hours later, and the specimen treatment group applied the specimen every measurement immediately after inflammation.

The test was conducted as described above, and it was determined that a plant-derived component in which suppression of paw edema was clearly observed as compared with the group not treated with the sample had an anti-inflammatory effect.

[0026]

[Table 1]

Examples and Comparative Examples Packing agents were prepared according to a conventional method so as to have the compositions shown in Tables 2 to 7, and the results are shown in Example 1.
Preparations for skin external preparations of Comparative Examples 1 to 5 and Comparative Examples 1 to 5 and spray packs (aerosol-type coating agents) were prepared according to a conventional method so as to have the compositions shown in Tables 8 to 13.
2 and Comparative Examples 6 to 10 were obtained.

A cataplasm (patch) was prepared according to a conventional method so as to have the composition shown in Tables 14 to 19, and
Skin external preparations of 3-77 and Comparative Examples 11-15, Tables 20-
A cream was prepared according to a conventional method so as to have the composition shown in No. 23, and skin external preparations of Examples 78 to 92 and Comparative Examples 16 to 20 were obtained.

Further, gel preparations were prepared according to a conventional method so as to have the compositions shown in Tables 24 to 27, to thereby obtain skin external preparations of Examples 93 to 107 and Comparative Examples 21 to 25.

In each of the above tables,% means% by weight, and mucopolysaccharide sulfate was used as the heparin-like substance.

With respect to the skin external preparations of the above Examples and Comparative Examples, the following test for judging the effect of removing blue bruise was carried out. The results are shown in each table. The following color difference measurement, sensory evaluation,
Immediately before, the external preparation for skin was removed from the skin of the test subject, or the skin was washed with a commercially available skin cleanser and then performed. <Judgment test of blue bruising effect> Color difference measurement method The skin external preparations of Examples and Comparative Examples were used as experimental preparations. Subjects were healthy volunteers in their 20s and 30s (8 women,
(6 men). Blue bruise was artificially created for the subject as follows.

That is, an Erlenmeyer flask with a branch (φ1.5 cm) was brought into close contact with 4 to 8 places on the inner side of the upper arm of the subject, and the rotary vacuum pump connected to the flask was turned on for 150 minutes.
Blue bruises (purple spots) were created by suctioning at Torr for 30 seconds (by the method of Kanai et al.).

With regard to the subjects with blue bruises prepared under the uniform conditions as described above, those who applied the appropriate amount of each of the prescribed experimental preparations to the blue bruise site three times a day were treated as treatment groups, and those who were left without applying anything. Was set as an untreated control group. In addition, for each subject, the skin color of the blue bruise site was measured once a day for 5 days immediately after the blue bruise was created using a colorimetric colorimeter. The determination of the blue bruise color difference at each measurement was made based on the reduction rate of the color difference ΔE value at each measurement with respect to the color difference ΔE value immediately after blue bruise creation. Judgment standard Blue bruise color difference judgment Reduction rate of ΔE value at each measurement with respect to ΔE value immediately after blue bruise creation × less than 10.0% △ 10.0% or more and less than 30.0% ３ 30.0% or more and 50.0% Less than 50.0% or more Sensory evaluation of blue bruise disappearance At the same time as determining the color difference at the blue bruise site, the color tone of the blue bruise was visually observed. The criteria for macroscopic observation are x for severe blue bruise (dark purple), △ for moderate blue bruise (light purple), 〇 for mild blue bruise (light yellow), and ◎ for disappearance of blue bruise.
Was evaluated in four steps.

[0034]

[Table 2]

[0035]

[Table 3]

[0036]

[Table 4]

[0037]

[Table 5]

[0038]

[Table 6]

[0039]

[Table 7]

[0040]

[Table 8]

[0041]

[Table 9]

[0042]

[Table 10]

[0043]

[Table 11]

[0044]

[Table 12]

[0045]

[Table 13]

[0046]

[Table 14]

[0047]

[Table 15]

[0048]

[Table 16]

[0049]

[Table 17]

[0050]

[Table 18]

[0051]

[Table 19]

[0052]

[Table 20]

[0053]

[Table 21]

[0054]

[Table 22]

[0055]

[Table 23]

[0056]

[Table 24]

[0057]

[Table 25]

[0058]

[Table 26]

[0059]

[Table 27]

The variance analysis of the treatment group in the color difference measurement in the determination test of the blue bruise elimination effect was performed on each of the treatment groups. The treatment group to which the external preparation was applied showed a significant difference at a risk rate of less than 5% or less than 1%, while the treatment group to which the skin external preparation of Comparative Examples 1 to 25 was applied had a risk rate of 5 %, No significant difference was observed.

According to the above results and the results of Tables 1 to 27,
The skin external preparation for blue bruise of the present invention, that is, a skin external preparation containing a plant-derived component having both blood circulation promotion and anti-inflammatory effects, and a plant-derived component having blood circulation promotion and a component having an anti-inflammatory effect in combination Skin external preparation (Examples 1 to 10)
7) has an excellent blue bruise eliminating effect, whereas blue bruise skin external preparations containing no component having an anti-inflammatory effect (Comparative Examples 1 to 25) are all blue bruise skin of the present invention. It was recognized that the blue bruising effect was inferior to that of the topical preparation.

 ──────────────────────────────────────────────────続 き Continuation of the front page (72) Inventor Hideaki Ozeki 1-3-7 Honjo, Sumida-ku, Tokyo Inside Lion Corporation (72) Inventor Akito Odaka 1-3-7, Honjo, Sumida-ku, Tokyo No. Lion Corporation

Claims (2)

[Claims] 1. An external preparation for blue bruises, comprising a plant-derived component having both a blood circulation promoting action and an anti-inflammatory action. 2. A skin external preparation for blue bruises, comprising a combination of a plant-derived component having a blood circulation promoting action and a component having an anti-inflammatory action.