JPH11322557A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an oral cavity composition having an excellent effect to give glosses to teeth and a high dental plaque-inhibiting effect by compounding dextranase, polyoxyethylene sorbitol beeswax, etc. SOLUTION: This composition for oral cavities contains (A) dextranase preferably in an amount of 0.1-1 wt.% based on the total amount of the composition and (B) polyoxyethylene sorbitol beeswax and/or polyoxyethylene lanolin in an amount of 0.1-5 wt.%. The composition may be compounded with a binder (for example, carrageenan), an abrasive, a viscous agent (for example, glycerol), a surfactant (for example, sodium lauryl sulfate or a sucrose fatty acid ester), a sweetener (for example, saccharin sodium), a perfume (for example, menthol), a colorant, etc., in the case of dentifrice. A fluoride (for example, sodium fluoride), an enzyme (for example, mutanase), tranexamic acid, ε-aminocaproic acid, etc., may further be compounded.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral composition having an excellent effect of imparting gloss to teeth and a high effect of inhibiting plaque.

[0002]

2. Description of the Related Art
It is known to mix shellac with a tooth cosmetic (Japanese Patent Laid-Open No. 4-82821). In addition, it has been proposed to mix wax or shellac in a dentifrice composition to impart gloss to teeth (International Publication WO 96/28134), and it has also been proposed to mix beeswax and lanolin.

[0003] However, since these compounds are insoluble in water, there is still room for study on the effect of giving gloss to the teeth and the effect of suppressing the adhesion of bacteria, and it is easier to use and gives the teeth gloss. There is a need for the development of an oral composition that suppresses bacterial adhesion.

[0004]

Means for Solving the Problems and Embodiments of the Invention The present inventor has conducted intensive studies in order to respond to the above demand, and as a result,
Dextranase is conventionally known as an active ingredient for inhibiting plaque formation (for example, Japanese Patent Application Laid-Open No. 48-56834).
Unexamined-Japanese-Patent No. JP-A-48-56836), surprisingly, by using dextranase in combination with beeswax, polyoxyethylene sorbit beeswax or polyoxyethylene lanolin, which imparts hydrophilicity to lanolin. The present inventors have found that an excellent gloss-imparting effect can be obtained and a plaque-suppressing effect can be enhanced, and the present invention has been accomplished.

Hereinafter, the present invention will be described in more detail. The oral composition of the present invention contains dextranase and polyoxyethylene sorbite beeswax and / or polyoxyethylene lanolin.

Here, the dextranase is a dextran obtained by a known method from a known dextranase-producing bacterium belonging to the genus Ketomium, the genus Penicillium, the genus Aspergillus, the genus Spicaria, the genus Lactobacillus, or the genus Servibrio. Dextranase produced by other microorganisms can of course be used, as well as enzymes.

The amount of dextranase is 0.01 to 5% (% by weight, hereinafter the same) of the whole composition, especially 0.1 to 5%.
Preferably, it is 1%.

On the other hand, polyoxyethylene sorbit beeswax and polyoxyethylene lanolin can be used as well-known ones, and commercial products can be used. For example,
As polyoxyethylene sorbit beeswax, Nikko Chemicals Co., Ltd. GBW-25 (HLB7.5),
GBW-125 (HLB9.5) and the like are used, and as polyoxyethylene lanolin, TW-10 (HLB12.0) and TW-20 (HL) manufactured by Nikko Chemicals Co., Ltd.
B13.0), TW-30 (HLB15.0) and the like.

A polyoxyethylene sorbite beeswax,
Polyoxyethylene lanolin can be used alone or in combination of two or more, and the amount of polyoxyethylene sorbite beeswax and polyoxyethylene lanolin is preferably 0.1 to 20% of the whole composition, Preferably it is 0.1 to 10%, more preferably 0.1 to 5%.

The oral composition of the present invention is prepared and applied as dentifrice such as toothpaste, liquid dentifrice, and lubricating dentifrice, mouthwash, chewing gum and the like.
In addition to the above-mentioned active ingredients, components can be appropriately compounded according to the type. For example, for toothpaste, an abrasive,
Thickeners, surfactants, sweeteners, flavors, coloring agents, other active ingredients, and the like can be added. In each case, the components conventionally used can be used in a usual dose.

Examples of the binder include cellulose derivatives such as carrageenan, sodium carboxymethylcellulose, methylcellulose, and hydroxyethylcellulose; alginic acid derivatives such as sodium alginate and propylene glycol alginate; One or more kinds of synthetic binders such as alcohol, sodium polyacrylate and carboxyvinyl polymer, and inorganic binders such as silica gel, veegum and laponite may be blended.

Examples of the thickener include glycerin, sorbitol, propylene glycol, polyethylene glycol,
One or more polyhydric alcohols such as ethylene glycol, reduced starch saccharified product, xylitol, and maltitol can be used.

[0013] Examples of the surfactant include anionic surfactants, nonionic surfactants, and amphoteric surfactants.

Examples of the anionic surfactant include sodium alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, and sodium N-lauroyl sarcosinate and N-myristoyl sarcosinate.
N-acyl glutamates such as sodium acylsarcosinate, sodium dodecylbenzenesulfonate, sodium hydrogenated coconut fatty acid monoglyceride monosulfate, sodium lauryl sulfoacetate, sodium N-palmitoylglutamate, sodium N-methyl-N-acyltaurate, N- Sodium methyl-N-acylalanine, sodium α-olefin sulfonate and the like are used.

Examples of the nonionic surfactant include sugar fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester and lactose fatty acid ester, sugar alcohol fatty acid esters such as maltitol fatty acid ester and lactitol fatty acid ester, and polyoxyethylene sorbitan monolau. Rate, polyoxyethylene sorbitan fatty acid ester such as polyoxyethylene sorbitan monostearate, polyoxyethylene fatty acid ester such as polyoxyethylene hydrogenated castor oil, lauric acid mono- or diethanolamide, fatty acid mono- or diethanolamide such as myristic acid mono- or diethanolamide Diethanolamide, sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene copolymer, polyoxy Etc. Ji Ren polyoxypropylene fatty acid ester is used.

[0016] Saccharin sodium,
Stevioside, dipotassium glycyrrhizinate, perillartin, thaumatin and the like can be blended.

As the fragrance component, menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, cineol, linalool, ethyl linalool, crocodile, thymol, peppermint oil, spearmint oil, wintergreen oil, T-shaped oil, eucalyptus oil and the like may be used alone or in combination. Blue No. 1 and Yellow 4 as colorants
No., titanium dioxide, etc. are used.

Other active ingredients include fluorides such as sodium fluoride and sodium monofluorophosphate, enzymes such as mutanase, lysozyme, amylase, protease, lytic enzyme, tranexamic acid, epsilon aminocaproic acid, and dipotassium glycyrrhizinate. Glycyrrhetinic acid, bisabolol, chlorophyll, sodium chloride, a water-soluble inorganic phosphate compound, triclosan, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride and the like.

[0019]

EFFECT OF THE INVENTION The oral composition of the present invention comprises a combination of dextranase and hydrophilic polyoxyethylene sorbit beeswax and polyoxyethylene lanolin, thereby giving gloss to teeth and inhibiting bacterial adhesion. It is highly effective.

[0020]

EXAMPLES The present invention will be specifically described below with reference to experimental examples and examples, but the present invention is not limited to the following examples. In the following examples,% indicates% by weight.

[Experimental example 1] Gloss imparting effect The labial tooth surfaces of the upper and lower anterior teeth of 10 subjects were used as test teeth.
About 1 g of a dentifrice having the composition shown in Table 1 was taken, and only the test tooth surface was freely brushed for 1 minute, and three judges determined the gloss of the test tooth before and after brushing. The subjects were divided into two groups, and one group was evaluated with the toothpaste of the comparative example, and one day later, the toothpaste of the example was evaluated. The other groups were evaluated in the order of Example and Comparative Example.

[0022]

[Table 1] <Results> Example 1 Example 2 Comparative Example 1 Unchanged 5 6 12 Neither 8 7 8 Slightly glossy 14 15 9 Clearly glossy 3 2 1 The dentifrice of the present invention is used as a comparative dentifrice. There was an excellent gloss imparting effect.

[Experimental Example 2] Three-week-old (male) golden hamsters were grouped into 10 rats, and each hamster was treated with streptomycin-resistant cariogenic bacteria Streptococcus.
mutans10449 strain was infected. Infection is carried out by inoculating one platinum loop of the strain into 4 ml of BHI medium (manufactured by BBL), culturing it at 36 ° C. for 20 hours under anaerobic conditions, and then dropping 0.1 ml of this bacterial solution into the mouth of each hamster. 3
Went for days. The colonization of the bacteria in each hamster was confirmed using an MS agar medium (manufactured by Difuco) containing 0.1% streptomycin. After confirming the colonization of the bacteria as described above, a dentifrice having the test dentifrice composition shown in Table 2 was produced, and a solution extracted with three times the amount of water was administered for 5 weeks. As an administration method, 0.1 ml of hamster was administered to the mouth twice a day. The diet during the experiment period was caries-inducing powder diet Diet20.
00 (manufactured by CLEA Japan) was used. As drinking water, ion-exchanged water filtered through a membrane filter having a pore size of 0.2 μm was used.

The condition of plaque adhered to each hamster is shown in molar 1
Shimada et al.'S method for two bottles (11 hygiene inspection technology courses)
And the total score was shown. Evaluation criterion 0: No plaque was exuded, and the contents of pits and fissures were only stained in dots or lines 1: 1: Less than 1/3 area covered with plaque exuded 2: An area of less than 2/3 covered with stained plaque 3: An area of 2/3 or more covered with stained plaque

[0025]

[Table 2]

Hereinafter, examples of the formulation will be shown.

[0027]

[Table 3]

Example 13 Mouthwash Ethanol 10.0% Glycerin 20.0 Polyoxyethylene hydrogenated castor oil 0.05 Fragrance 0.8 Dextranase 0.1 Polyoxyethylene lanolin (TW-30) 0 Sodium fluoride 0.23 Water balance 100.0%

Example 14 Gum Gum Base 20.0% Syrup 5.0 Glycerin 2.0 Sorbit 71.3 Dextranase 0.2 Polyoxyethylene Sorbit Beeswax (GBW-25) 2.0 Perfume 1.0 Total 100.0%

 ──────────────────────────────────────────────────続 き Continuing from the front page (72) Inventor Yasuhiro Akabane 1-3-7 Honjo, Sumida-ku, Tokyo Inside Lion Corporation

Claims (1)

[Claims] 1. An oral composition comprising dextranase and polyoxyethylene sorbite beeswax and / or polyoxyethylene lanolin.