JPH11193225A - Moisturizer and preparation for external use for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a moisturizer and a preparation for external use for skin which show excellent moisturizing property and possess excellent usability. SOLUTION: This is a moisturizer characterized by consisting of 1,2,4- butanetriol and a preparation for external use for skin containing it. 1,2,4- Butanetriol is usually blended in an amount of 0.5-40 wt.%, preferably 3-20 wt.%, based on the whole weight of the preparation for external use for skin as an moisturizer. In the concentration of less than 0,5 wt.% sufficient moisturizing effect is not obtained and further in the concentration of more than 40 wt.%, greasy heavy touch on use can not be avoided.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a humectant and an external preparation for skin containing the same. More specifically, the present invention relates to a moisturizing agent having an excellent moisturizing effect and an extremely good use feeling, and a skin external preparation containing the same.

[0002]

2. Description of the Related Art The stratum corneum of normal skin usually has a thickness of 10 to 20%.
% Moisture, and retains its elasticity, flexibility and protection function. However, when the moisture in the stratum corneum decreases due to changes in the external environment such as temperature and humidity, it becomes a state called dry skin. It has been known that the skin loses its elasticity and protective function and causes various troubles.

[0003] Conventionally, a humectant has been incorporated into cosmetics for the purpose of improving or preventing such dry skin.

As humectants, for example, polyethylene glycol, dipropylene glycol, glycerin,
Polyols such as 3-butylene glycol and dipropylene glycol, amino acids, polysaccharides, urea, lactic acid, hyaluronic acid and the like are used, but polyols are widely used in terms of moisturizing effect on skin and usability.

[0005] However, in cosmetics which have a high moisturizing property on the skin, impart skin and moisture to the skin, and have a high effect of improving rough skin, the amount of the polyol compounded is increased, or the viscosity of the polyol is increased. There is a tendency to mix high glycerin and polyglycerin in large amounts,
It caused stickiness to the skin.

The inventors of the present invention have conducted intensive studies in view of the above circumstances, and as a result, an external preparation for skin containing 1,2,4-butanetriol has excellent skin moisturizing action, high skin roughness improving action, and furthermore, skin In addition to having a high effect of improving fine wrinkles,
The inventor has also found that the present invention is excellent in the effect of improving the feeling in use, and has completed the present invention.

The present invention provides a moisturizing agent excellent in both usability and moisturizing effect, and an external preparation for skin having excellent moisturizing effect, skin roughness improving effect, skin fine wrinkle improving effect and usability which are blended with the moisturizing agent. Aim.

[0008]

That is, the present invention provides:
A moisturizer characterized by comprising 1,2,4-butanetriol.

The present invention also provides an external preparation for skin characterized by containing 1,2,4-butanetriol.

Further, the present invention relates to a method of preparing 1,2,4-butanetriol in an amount of 0.5 to 40% by weight based on the total amount of the external preparation for skin.
It provides the above-mentioned skin external preparation characterized by containing.

[0011]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The configuration of the present invention will be described below in detail.

Although the moisturizing effect of polyols is generally known, glycerin, for example, is one of the polyols currently widely used in cosmetics which has good permeability in the stratum corneum but has low permeability and consequently glycerin which does not penetrate. It has the disadvantage that it remains on the skin and gives a sticky feeling.
-Butylene glycol and dipropylene glycol have a good feeling of use because they have a good penetration into the stratum corneum and do not easily remain on the skin, but have a weak retention in the stratum corneum and cannot maintain a moisturizing action.

The present inventors have conducted intensive studies on the moisturizing action of the polyol and the amount of the polyol present in the stratum corneum, and there is a very good correlation between the two. Further, regarding the amount present in the stratum corneum, It has been found that the ease with which the polyol penetrates into the stratum corneum is related to the time during which the polyol permeated into the stratum corneum is retained. In addition, good permeability means that it quickly penetrates into the stratum corneum from above the skin,
Not remaining on the skin was an important physical property for improving the tackiness of the polyol. That is, the most excellent polyol-based humectant has excellent permeability to the stratum corneum, and has physical properties that are retained in the stratum corneum for a long time after permeation. And 1,2,4-butanetriol as a polyol with excellent permeability and excellent retention in the stratum corneum, excellent moisturizing action, and excellent use feel. The present invention has been completed. As described above, the present invention has been completed as a result of finding that the humectant has a remarkable and unique effect as compared with a conventionally known humectant of a polyol compound. Triol has never been used in skin external preparations as a moisturizer.

In the present invention, 1,2,4-butanetriol is usually used as a moisturizing agent based on the total amount of the external preparation for skin.
The content is 0.5 to 40% by weight, preferably 3 to 20% by weight. If it is less than 0.5%, a sufficient moisturizing effect cannot be obtained, and if it exceeds 40% by weight, a sticky and heavy use feeling cannot be avoided.

The external preparation for skin of the present invention is a humectant composition, and in addition to the above essential components, an oil component generally used as an external preparation for skin, as long as the effects of the present invention are not impaired.
Surfactants, moisturizers other than those described above, ultraviolet absorbers, chelating agents, pH adjusters, preservatives, thickeners, dyes, fragrances, chemicals, and other components are appropriately blended, and are usually used according to the intended dosage form. It can be manufactured by a method.

The dosage form of the external preparation for skin of the present invention is arbitrary,
Solution type, solubilization type, emulsification type, powder dispersion type, water-two-phase type,
Any dosage form such as a water-oil-powder three-phase type may be used.
The use of the external preparation for skin of the present invention is also optional, for example,
It can be used as a facial, such as a lotion, an emulsion, a cream, a pack, and a conditioner, or as an external preparation for the body, scalp, or hair.

The external preparation for skin of the present invention includes cosmetics,
An external preparation applied to skin or hair as a drug or a quasi drug.

[0018]

The present invention will now be described more specifically with reference to examples. Note that the present invention is not limited only to the following examples. The compounding amount is% by weight.

"Permeability of humectant into stratum corneum" The following test was conducted on the permeability of the humectant into the stratum corneum and compared with dipropylene glycol and glycerin. The results are shown in FIG.

[Test Method] 10 panel members specialized in evaluation (n =
10) After washing the inner part of the forearm with soap, 15 μL of a 10% aqueous solution of a humectant was applied to an area of 15 cm ^2. After 30 minutes and 6 hours, the soap was washed, and eight layers of the stratum corneum were tape-stripped from the same site. Collected. The humectant in the stratum corneum was extracted with methanol, and the extracted humectant was quantified by gas chromatography. The weight of the stratum corneum was determined from the change in tape weight before and after collection. The average value (n = 10) of the humectant in the stratum corneum after 30 minutes and after 6 hours is shown in FIG.

The following is clear from FIG. (A) The concentration of dipropylene glycol in the stratum corneum after 30 minutes is very high, but hardly remains in the stratum corneum after 6 hours and is not well retained in the stratum corneum. (B) The concentration of glycerin in the stratum corneum after 30 minutes and after 6 hours hardly changed, and the retention in the stratum corneum was good but the permeability was low. (C) 1,2,4-butanetriol has a higher penetration amount into the stratum corneum than dipropylene glycol and glycerin, and is excellent in retention in the stratum corneum.

"Moisturizing effect and usability of external preparation for skin" The moisturizing effect and useability of the external preparation for skin of the present invention were examined. That is, an aqueous humectant solution (lotion), which is an external preparation for skin of the present invention, was prepared based on the formulation in Table 1, and the moisturizing action and usability (moist feeling,
(Evaluation of stickiness and stickiness) was performed. The results are shown in Table 1.

[Test Method] 10 panel members specialized in evaluation (n =
After washing the inner part of the forearm of 10) with soap, 23 ° C, 50
% After 30 minutes in a constant temperature and humidity chamber, the water content in the stratum corneum was measured using a high-frequency impedance meter (SKICON200, IBS).
Manufactured by the company). Next, the lotion shown in Table 1 above was applied to the test site under the condition of 1 μL / cm ² , and after 6 hours, the skin was washed with soap to remove the lotion on the skin. Was measured for water content. The skin moisturizing effect was evaluated by the ratio of the water content of the stratum corneum before and after application.

The moisturizing action was evaluated according to the following evaluation criteria by the average value at n = 10. The larger the value, the higher the moisturizing effect on the skin. "Evaluation criteria" A: 1.6 or more B: 1.3 to 1.5 C: 1 to 1.2 X: Less than 1

The usability of each of the items of moist feeling, rubbing feeling and sticky feeling is as follows.
The following evaluation criteria were used for evaluation based on the number of people judged to be good. "Evaluation Criteria" A: Eight or more out of ten responded that the feeling of use was good. ：: 6 to 7 out of 10 persons answered that the feeling of use was good. B: 4 to 5 out of 10 persons answered that the feeling of use was good. ×: 3 or less of 10 persons answered that the feeling of use was good.

[0026]

[Table 1] ---------------------------------------------- ----------------------- Example Comparison Example 1 2 3 4 5 1 2 3 ------------- -------------------------------------------------- ------ 1,2,4-Phthanetriol 0.5 3 10 20 25---Quercerin-----10--Chloropropylene glycol--------10-1,3-butylene glycol-- -----10 Ion exchange water Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining --------------------------------- ------------------------------------ Moisturizing effect ○ ○ ◎ ◎ ◎ ◎ × × Moist feeling △ ○ ◎ ◎ ◎ ○ △ △ Severing feeling ○ ◎ ◎ ◎ ◎ ○ △ × Sticky feeling ◎ ◎ ◎ ○ △ × ◎ ◎ ---------------------- -----------------------------------------------

As is clear from Table 1, the examples of the present invention have excellent moisturizing action and good usability as compared with the comparative examples of the conventionally used moisturizers. I understood.

Next, the skin roughness improving effect and the skin wrinkle improving effect of the external preparation for skin of the present invention were confirmed by use tests. The use test was conducted by dividing the panel of 20 female professionals for evaluation into two groups. The first group used the lotion of Example 6 and Comparative Example 4 and the second group used the creams of Example 7 and Comparative Example 5 daily. After washing the face twice a day in the morning and at night, apply an appropriate amount to each of the right and left halves of the face for 2 weeks, and evaluate the effect of improving rough skin and fine wrinkles on the skin by evaluating the number of respondents who are effective, slightly effective, or ineffective did. At the same time, for usability,
Evaluation was carried out using the same evaluation criteria as in Example 1 described above, and the results are shown in "Table 2".

Example 6 Lotion A lotion was prepared according to the following formulation by a conventional method. Ethanol 5% by weight 1,2,4-butanetriol 10 Polyoxyethylene (20 mol) Oleyl alcohol ether 1.5 Jojoba oil 0.5 EDTA-3Na 0.01 Preservatives Appropriate amount Perfume Appropriate amount Ion exchange water balance

"Comparative Example 4 Lotion" A preparation was carried out in the same manner as in Example 6. Ethanol 8% by weight 1,3-butylene glycol 5 Dipropylene glycol 5 Polyoxyethylene (20 mol) oleyl alcohol ether 1.5 Jojoba oil 0.5 EDTA-3Na 0.01 Preservative Appropriate amount Fragrance Appropriate amount Ion-exchanged water residue amount

Example 7 Cream A cream was produced by a conventional method according to the following formulation. 1,2,4-butanetriol 10% by weight dipropylene glycol 5 squalane 20 petrolatum 5 cetostearyl alcohol 3 polyoxyethylene (20 mol) oleyl alcohol ether 1.5 glyceryl monostearate 1.5 urea 2 sodium lactate 1 xanthan gum 0 0.05 Preservatives Appropriate amount Caustic potash 0.01 EDTA-3Na 0.01 Perfume Appropriate amount Residual ion-exchanged water

"Comparative Example 5 Cream" Prepared in the same manner as in Example 7. Glycerin 10% by weight Dipropylene glycol 5 Squalane 20 Vaseline 5 Cetostearyl alcohol 3 Polyoxyethylene (20 mol) oleyl alcohol ether 1.5 Glyceryl monostearate 1.5 Urea 2 Sodium lactate 1 Xanthan gum 0.05 Preservative Appropriate amount Caustic potash 0.01 EDTA-3Na 0.01 Appropriate amount of perfume Residual ion exchange water

[0033]

[Table 2] ---------------------------------------------- ---------------------- Example 6 Comparative Example 4 Example 7 Comparative Example 5 ---------------- -------------------------------------------------- -"Skin roughening improvement effect" Effective 60 8 6 Slightly effective 4 2 3 3 Invalid 0 8 0 1 Effective rate 100% 20% 100% 90% ----------------- -------------------------------------------------- -"Improvement effect of fine wrinkles" Effective 3 0 5 2 Slightly effective 5 2 4 5 Invalid 2 8 1 3 Effective rate 80% 20% 90% 70% ----------------- -------------------------------------------------- -Moist ◎ △ ◎ ○ Smoothness ◎ × ◎ ○ Stickiness ◎ ◎ ◎ × ----------------------------- ---------------------------------------

As can be seen from Table 2, the external preparation for skin of the present invention was excellent in the effect of improving rough skin, the effect of improving fine wrinkles on the skin, and the usability was good.

The following are other examples of the external preparation for skin of the present invention.

Example 8 Emulsion An emulsion was prepared according to the following formulation by a conventional method. 1,2,4-butanetriol 7 glycerin 5 sodium pyrrolidonecarboxylate 0.5 squalane 5 petrolatum 1 cetostearyl alcohol 0.3 polyoxyethylene (20 mol) oleyl alcohol ether 1.5 sodium polyacrylate 0.03 preservative 0.2 Caustic potash 0.1 EDTA-3Na 0.03 Perfume Appropriate amount Deionized water balance

Comparative Example 6 Emulsion Emulsion was prepared in the same manner as in Example 8. 1,3-butylene glycol 7 glycerin 5 sodium pyrrolidonecarboxylate 0.5 squalane 5 petrolatum 1 cetostearyl alcohol 0.3 polyoxyethylene (20 mol) oleyl alcohol ether 1.5 sodium polyacrylate 0.03 preservative 0. 2 Caustic potash 0.1 EDTA-3Na 0.03 Perfume Appropriate amount Ion-exchanged water balance

The emulsion of Example 8 is different from that of Comparative Example 7 in comparison with the emulsion of Comparative Example 7.
It was excellent in moisturizing action and usability.

Example 9 Cream A cream was produced according to the following formulation by a conventional method. 1,2,4-butanetriol 15% by weight glycerin 3 erythritol 1 cetostearyl alcohol 4 petrolatum 5 squalane 3 jojoba oil 3 dimethyl silicone (6 mP · s) 5 glyceryl monostearate 2.5 polyoxyethylene (5 mol) glyceryl mono Stearate 1.5 Polyoxyethylene (20 mol) oleyl alcohol ether 3 Vitamin E acetate 0.05 Preservatives qs EDTA-3Na 0.03 Perfume qs Ion exchange water balance

Comparative Example 8 Cream A cream was produced in the same manner as in Example 9. Dipropylene glycol 15% by weight glycerin 3 erythritol 1 setosteryl alcohol 4 petrolatum 5 squalane 3 jojoba oil 3 dimethyl silicone (6 mP · s) 5 glyceryl monostearate 2.5 polyoxyethylene (5 mol) glyceryl monostearate 1.5 Polyoxyethylene (20 mol) oleyl alcohol ether 3 Vitamin E acetate 0.05 Preservatives appropriate amount EDTA-3Na 0.03 Perfume appropriate amount Ion-exchanged water balance

The cream of Example 9 was superior to the cream of Comparative Example 8 in the moisturizing action and the usability.

Example 10 Hair Treatment A hair treatment was produced according to the following formulation by a conventional method. 1,2,4-butanetriol 10% by weight cetostearyl alcohol 3 stearyltrimethylammonium chloride 2 dimethyl silicone (20 mP · s) 10 preservative appropriate amount perfume appropriate amount ion-exchanged water balance

"Comparative Example 9 Hair treatment" Manufactured in the same manner as in Example 10. 1,3-butanediol 10% by weight cetostearyl alcohol 3 stearyltrimethylammonium chloride 2 dimethyl silicone (20 mP · s) 10 preservative suitable amount perfume suitable amount ion-exchanged water balance

The hair treatment of Example 10 had an improved moisturizing effect on hair as compared with the hair treatment of Comparative Example 9, and had excellent usability.

[0045]

According to the present invention, it is possible to provide a moisturizing agent and a skin external preparation having a high moisturizing effect for improving rough skin, improving fine wrinkles on the skin, and improving damaged hair and having excellent usability. .

[Brief description of the drawings]

FIG. 1 is a graph showing the amount of a humectant in a stratum corneum.

[Explanation of symbols]

 (A): dipropylene glycol (B): glycerin (C): 1,2,4-butanetriol

Claims (3)

[Claims] 1. A humectant comprising 1,2,4-butanetriol. 2. An external preparation for skin comprising 1,2,4-butanetriol. 3. The external preparation for skin according to claim 2, wherein said 1,2,4-butanetriol is contained in an amount of 0.5 to 40% by weight based on the total amount of the external preparation for skin.