JPH11193010A - Pasteurization method in medical pasteurization packaging - Google Patents

Abstract

PROBLEM TO BE SOLVED: To enable medical pasteurization packaging which can surely prevent a residue of gas and is applicable to even to a packaging material made of a polyester resin, by subjecting a gas-barrier-property-having container to the process of pasteurization with hydrogen peroxide gas, and thereafter subjecting it to the process of degassing while increasing temperature. SOLUTION: Package containers each are loaded into a chamber together with a carriage (S1), a vacuum pump is started to exhaust air in it via a catalytic device (S2) and produce a vacuum in, and hydrogen peroxide gas is supplied and caused to diffuse in the chamber (S3) and allowed to permeate through pasteurizing paper, thereby effectively spreading the hydrogen peroxide gas into the package container (S4). These operations are repeated one to twelve times, the hydrogen peroxide gas is decomposed by the catalytic device and exhausted safely out of a system, thereby producing a vacuum in (S5), and the inside of the chamber is allowed to have atmospheric pressure (S6). Air increased in its temperature is caused to flow back and the inside of the package container is subjected to a degassing process (S7), and the processed package container is taken out (S8). Therefore, the container main body made of a polyester resin which is excellent in transparency and easy to dispose of can be used.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for sterilizing medical sterile packaging, and more particularly, to a method for packaging a medical product, for example, a syringe containing a drug, packed in a packaging container with hydrogen peroxide gas as it is. BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a sterilization method for performing a sterilization process, which can efficiently perform a process and reliably prevent a residual hydrogen peroxide gas.

[0002]

2. Description of the Related Art As with other disposable medical devices, it is preferable that a syringe containing a medicine be distributed in a sterilized medical package. The medical sterilization packaging uses a medical container made of a synthetic resin container body having a gas barrier property and a sterile paper as a lid material through which the sterilizing gas can pass and which can be welded to the container body. This is a form of packaging in which the product is sealed and then exposed to a sterilizing gas in a packaged state so that the inside is sterilized with a sterilizing gas that has passed through sterilized paper.

[0003] In the above-mentioned medical sterile packaging, the use of hydrogen peroxide gas instead of ethylene oxide has been studied for various medical products due to the problem of the toxicity of the sterilizing gas. Regardless of the type of hydrogen gas used, post-treatment of removing sterilizing gas from the inside of the packaging container is indispensable in order to eliminate the harmfulness of the residual gas to the human body during the distribution process. The technology related to sterilization and sterilization using hydrogen peroxide is disclosed in JP-B-61-45.
No. 43, Japanese Patent Application Laid-Open No. 1-121057 and the like.

[0004]

In medical sterilization packaging, however, it is necessary to leave the packaging container for a considerably long time to completely remove the sterilizing gas from the packaging container after the sterilization treatment. It is a factor that lowers. In addition, when a container made of polyester resin is used, the adsorption of sterilizing gas is high, and it becomes more difficult to remove the sterilizing gas. Therefore, in practice, containers mainly containing vinyl chloride are often used. I have. As a result, there is a problem in that visibility inside the packaging container is poor, and chlorine is generated during the disposal of vinyl chloride.

The present invention has been made in view of the above circumstances, and has as its object to provide, for example, a sterilization method for sterilizing a drug-containing syringe or the like with a hydrogen peroxide gas in a package without any treatment. It is an object of the present invention to provide a sterilization method for medical sterile packaging that can prevent hydrogen peroxide gas from remaining, and can be applied to a packaging material of a polyester resin.

[0006]

In order to solve the above-mentioned problems, a sterilization method in a medical sterilization package according to the present invention comprises:
A sterilization method for sterilizing a medical product enclosed in a packaging container with hydrogen peroxide gas, wherein the packaging container includes a container body made of a synthetic resin having a gas barrier property, and a container capable of transmitting hydrogen peroxide gas. After using a container composed of sterilized paper as a lid material that can be welded to the main body, and sterilizing with hydrogen peroxide gas, degas the hydrogen peroxide gas from the inside of the packaging container while heating. It is characterized by the following.

[0007] In the above sterilization method, the medical product is sterilized with hydrogen peroxide gas that has passed through the sterilizing paper of the packaging container, and then heated to promote desorption of the hydrogen peroxide gas adsorbed on the container body. Then, the hydrogen peroxide gas remaining inside the packaging container is removed.

[0008] In the above sterilization method, the medical product enclosed in the packaging container is stored in a chamber as a sterilizer and sterilized, and then the circulated air is circulated while the heated air is circulated through the chamber. The hydrogen peroxide gas contained in the chamber is decomposed by a catalytic reaction, so that the concentration of hydrogen peroxide gas in the chamber is always maintained at a low level in the degassing process of the hydrogen peroxide gas, and the peroxide is efficiently and safely oxidized. Hydrogen gas can be degassed.

Further, in the above embodiment, the operation of supplying the hydrogen peroxide gas to the depressurized chamber is repeated a plurality of times, so that the hydrogen peroxide gas permeates the inside of the packaging container quickly and reliably in the sterilization treatment. Can be done.

[0010]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS One embodiment of a method for sterilizing medical sterile packaging according to the present invention will be described with reference to the drawings.
FIG. 1 is a process chart showing each operation process of the sterilization method according to the present invention. FIG. 2 is a system diagram showing an outline of a chamber as a sterilization apparatus for performing the sterilization method according to the present invention. FIG. 3 is an external perspective view showing an embodiment of a packaging container in which a medicine-containing syringe is sealed, and FIG. 4 is an exploded perspective view showing the packaging structure of the packaging container in FIG. 3 from the bottom side. FIG. 5 shows a packaging container (packaged product) in the chamber.
It is a perspective view which shows the handling method of.

[0011] The sterilization method of the present invention is a sterilization method in a so-called medical sterilization package in which a medical product (including a medicine, a medical device, and the like) enclosed in a specific packaging container is sterilized by a hydrogen peroxide gas in a packaged state. It is. As a medical product suitable for sterile medical packaging, for example, a drug-containing syringe (4) as shown in FIG. 4 can be mentioned. As is well known, the drug-containing syringe (4) is a syringe which is pre-filled with a required drug and which can be used immediately with an injection needle attached thereto.
150868 and the like.

That is, the medicine-containing syringe (4) has a syringe barrel (41) in which a cap (42) is attached to the tip of a syringe needle mounting portion, and a syringe barrel (41) having a piston at the tip.
The piston rod (44) inserted into the
And 1) a drug filled therein. In addition, a syringe (4
An adapter (auxiliary tool) (47) for hooking a finger at the time of use is attached to the flange (43) of 1).
Such an adapter (47) also has a function of preventing the medicine-containing syringe (4) from swinging when housed in a packaging container described later. As the medicine to be filled into the medicine-containing syringe (4), a medicine unsuitable for heat sterilization, typically, a sodium hyaluronate solution or the like is suitable.

As shown by reference numeral (1) in FIG. 3, the packaging container has a container body (2) made of a synthetic resin having a gas barrier property and a container body (2) permeable to hydrogen peroxide gas. )) And sterilized paper (3) as a lid material that can be welded. The container body (2) is integrally formed in an elongated container shape with a transparent resin, and is opened.
Is sealed with sterile paper (3).

As the resin material constituting the container body (2), any thermoplastic resin can be used as long as the material does not allow bacteria to permeate and the contents can be visually recognized. From the viewpoint, the container body (2)
Is preferably made of a polyester resin such as polyethylene terephthalate (PET) and polybutylene terephthalate. Specifically, the container body (2) is manufactured by a molding method such as blister molding or deep drawing using a PET film having a thickness of 200 to 600 μm. In particular, the container main body (2) made of a PET film does not generate toxic gas such as chlorine at the time of disposal and is a preferable packaging material from the viewpoint of preventing pollution.

As shown in FIGS. 3 and 4, the container main body (2) has a first bulging portion for accommodating the distal end side of the syringe barrel (41) of the medicine-containing syringe (4) when viewed from the outside. (21)
And a second housing for accommodating a substantially central portion of the entire length of the medicine-containing syringe (4) including the piston rod (44) inserted partway.
Bulge (22) and the flange (4) of the syringe barrel (41).
3) and a third bulged portion (23) for accommodating the pusher (extended diameter enlarged portion) (45) of the piston rod (44), and two constricted portions (24) for connecting these bulged portions. , (2
4).

The first bulging portion (21) and the third bulging portion (23) of the container body (2) form relatively large spaces at both ends of the medicine-containing syringe (4). It functions to temporarily store the sterilizing gas that diffuses into details such as the gap between (41) and the piston rod (44), and the central second bulge (22) serves as a packaging container (1). Functioning as a bending fulcrum of the container body (2) for easily and hygienically removing the syringe (4) containing the medicine from the container.

On the other hand, each constricted portion (2) of the container body (2)
4) When many are stacked in the sterilization process described below,
A gap is formed between the upper and lower packaging containers (1) to improve the flow of hydrogen peroxide gas and air. Furthermore,
From such a viewpoint, the first bulging portion (2) of the container body (2) is used.
1) and the third bulge (23) are configured as support points for stacking, and the second bulge (22) is composed of the first bulge (21) and the third bulge. Preferably, it is formed at a height lower than (23). In a preferred embodiment, in order to reduce the contact area of the upper or lower packaging container (1) with the sterilizing paper (3), a saddle-shaped concave portion is provided at the center of the third bulging portion (23). (25) is formed.

As the sterilized paper (3), a material that is permeable to microorganisms such as bacteria and permeable to gas such as sterilizing gas and air, for example, known as "Tyvek 1073B" manufactured by DuPont. High density polyethylene sheet material is preferably used. Such a sterilized paper (3) is hermetically welded by an ultrasonic welding method or a heat welding method after accommodating the above-mentioned medicine-containing syringe (4) in the container body (2).

In carrying out the sterilization method of the present invention, a chamber (5) as a sterilization apparatus as shown in FIG.
Is used. The chamber (5) is designed, for example, as an airtight horizontally-long pressure-resistant container, and is packaged (packaged product).
(1) The pallet on which (see FIG. 5) is loaded can be loaded from the door on one end face. Such a chamber (5)
Is provided with a hydrogen peroxide gas supply line (A), a decompression line (B), an air introduction line (C) and a hot air circulation line (D), and a decompression line (B) and a hot air circulation line. A catalytic device (54) for decomposing hydrogen peroxide gas is interposed in the line (D).

The above hydrogen peroxide gas supply line (A)
A hydrogen peroxide generator (51) comprising a mechanism for measuring and supplying a fixed amount of a hydrogen peroxide solution and a gas generating system for heating and gasifying the supplied solution; and a hydrogen peroxide generator ( 51) through a gate valve (61) and into a chamber (5) through a gate valve (61). At the tip of the pipe (71), a plurality of nozzles (81) are provided via branch pipes. Provided.

The pressure reducing line (B) is connected to a vacuum pump (52).
And a pipe (72) extending from a plurality of suction ports (82) provided on the other side end surface of the chamber (5) to a suction side of the vacuum pump (52), and a discharge side of the vacuum pump (52). Pipe (73), a gate valve (62), and a catalyst device (54) for rendering the hydrogen peroxide gas discharged from the chamber (5) harmless. On the exhaust side of the catalyst device (54), A gate valve (63) for releasing oxygen gas generated by the decomposition process is provided. Note that a dry pump is used as the vacuum pump (52) in order to avoid deterioration of the lubricating oil due to hydrogen peroxide gas.

The air introduction line (C) is branched from the pipe (71) and has a filter (6) at the open end.
4) and a pipe provided with a gate valve (65). That is, a hydrogen peroxide gas supply line (A)
When the gate valve (61) is closed, air is introduced into the chamber (5) by opening the gate valve (65).

The hot air circulation line (D) is constituted by sequentially connecting the above-described catalyst device (54), circulation fan (55) and heater (56). In the catalyst device (54), for example, a pipe (74) extending from a plurality of intake ports (83) provided on one side wall of the chamber (5) is a gate valve (6).
6). The circulation fan (55) is disposed downstream of the catalyst device (54), and a pipe (75) extending from the exhaust side of the circulation fan (55) is connected to the heater (56). A pipe (76) leading to a plurality of outlets (84) provided on the other side wall of the chamber (5) is connected to the outlet side of the heater (56). As described above, the catalyst device (54) is installed to decompose hydrogen peroxide gas in both the pressure reduction line (B) and the hot air circulation line (D), and the catalyst device (54) A known device containing a reducing agent such as platinum is used.

In the sterilization method of the present invention using the chamber (5), as shown in FIG.
The operation is performed along the operation process of step (S9). First, a packaging container (packaged product) (1) to be sterilized is loaded on a truck and loaded into the chamber together with the truck. At that time, FIG.
As shown in (1), the packaging containers (1) are arranged in a large number of rows (only one row is illustrated for example) and loaded on a cart in a state of being vertically stacked in multiple stages (step (S1)) in order to increase processing efficiency. )).

Next, after closing the chamber (5),
The gate valves (62) and (63) of the pressure reducing line (B) are opened (the gate valve (66) of the hot air circulation line (D) is closed).
In addition, the vacuum pump (52) is started, and the internal air is exhausted through the suction port (82), the pipes (72) and (73), and the catalyst device (54), so that the inside of the chamber (5) is approximately 10 to 30 torr. Reduce the pressure. By such an operation, in the loaded packaging container (1), the internal air is exhausted through the sterilizing paper (3). (Step (S2))

In the operation of the above step (S2), the degree of vacuum of the chamber (5) is preferably high to some extent in order to sufficiently infiltrate the hydrogen peroxide gas into the inside of the packaging container (1), but is not so high. Then, if air is mixed into the medicine-containing syringe (4), the piston rod (44) may be unnecessarily popped out of the syringe barrel (41). Is preferred.

Subsequently, the vacuum pump (52) of the pressure reducing line (B) is stopped or switched to the idling operation, the gate valves (62) and (63) are closed, and then the hydrogen peroxide gas supply line (A) is connected. Supply hydrogen peroxide gas.
The hydrogen peroxide gas is supplied to the pipe (7) by opening the gate valve (61) and operating the hydrogen peroxide generator (51).
1) and diffused into the chamber (5) through the plurality of nozzles (81) (Step (S3)).

After supplying the hydrogen peroxide gas, the state in which the gas is filled in the chamber (5) is maintained for about 1 to 10 minutes, and the inside of the packaging container (1) including the syringe (4) containing the medicine is sterilized. To process. Since the inside of the packaging container (1) has been pre-pressurized by the decompression operation in the step (S2), the sterilizing paper (3) is permeated and hydrogen peroxide gas is further diffused into the packaging container (1). It can be made to penetrate efficiently (step (S4)).

When sterilizing a medical product having a simple shape, a single sterilization operation is sufficient, but the sterilization of the packaging container (1) in which the drug-containing syringe (4) as described above is enclosed is sterilized. In the case, the injection cylinder (41) and the piston rod (4
It is necessary to sterilize the details such as 4). Therefore, the above-described sterilization operation, that is, the operation of supplying hydrogen peroxide gas to the decompressed chamber (5) is repeated a plurality of times. Specifically, the operation from step (S2) to step (S4) is repeated 1 to 12 times. As a result, the hydrogen peroxide gas can be surely penetrated into the details of the medicine-containing syringe (4).

After the sterilization operation has been completed a predetermined number of times, the hydrogen peroxide gas supply line (A) is closed and the decompression line (B) is operated again, so that hydrogen peroxide is removed from the chamber (5). Exhaust gas. That is, the gate valve (61) of the hydrogen peroxide gas supply line (A) is closed, and the gate valves (62) and (63) of the pressure reducing line (B) are closed.
Is released and the vacuum pump (52) is operated to exhaust the hydrogen peroxide gas inside. At that time, the hydrogen peroxide gas
It is decomposed into oxygen and water by the catalyst device (54), is evacuated safely to the outside of the system, and the pressure in the chamber (5) is reduced to about 10 to 30 torr (step (S)
5)).

Next, the pressure reducing line (B) is closed, and the chamber (5) is passed through the air introducing line (C).
Introduce air into the In the air introducing operation, the gate (65) is opened to open the filter (64),
Air is introduced through the pipe (71) and the plurality of nozzles (81), and the pressure in the chamber (5) is restored to the atmospheric pressure.
Then, after the inside of the chamber (5) is set to the atmospheric pressure, the gate valve (65) is closed (step (S6)).

Subsequently, the hydrogen peroxide gas remaining inside the packaging container (1) is removed. Removal of hydrogen peroxide gas
Although it can be removed to some extent only by exposure to air, it must be left for an extremely long time, and PE
Depending on the material of the container body of the packaging container such as the above-mentioned polyester resin such as T, there is a problem that the hydrogen peroxide gas cannot be completely removed due to a high adsorption force. Therefore,
In the present invention, the hydrogen peroxide gas is degassed from the packaging container (1) while heating. Thereby, desorption of the hydrogen peroxide gas from the container body (2) is promoted, the hydrogen peroxide gas can be degassed more quickly, and the residual hydrogen peroxide gas can be reliably prevented. As the above-mentioned heating method, a method of circulating the heated air to the chamber (5) is preferable.

Specifically, the gate valve (66) of the hot air circulation line (D) is opened, and the circulation fan (55) and the heater (56) are operated. The circulation fan (55) sucks the air in the chamber (5) sucked from the plurality of intake ports (83) into the catalyst device (54) through the pipe (74), and the hydrogen peroxide gas is generated by the catalyst device (54). Supplying the removed air to the heater (56) through a pipe (75);
Then, the air heated by the heater (56) is returned to the chamber (5) through the plurality of outlets (84) (Step (S7)).

In the above step (S7),
By setting the temperature in the chamber (5), that is, adjusting the heater (56), hydrogen peroxide gas is supplied from the inside of the packaging container (1) under a hot air condition of about 30 to 120 ° C, preferably 30 to 100 ° C. Degassing is important.
The reasons for defining the temperature conditions are as follows. That is,
When the temperature of the hot air is lower than 30 ° C., it is difficult to desorb hydrogen peroxide gas from the surface of the polyester resin film of the container body (2), so that the degassing efficiency is reduced.
If the temperature of the hot air is higher than 120 ° C., the drug filled in the drug-containing syringe (4) may have a temperature substantially higher than 100 ° C. and deteriorate.

The degassing process in step (S7) is usually
It is performed for about 30 to 120 minutes, and the hydrogen peroxide gas remaining inside the packaging container (1) is discharged through a sterilized paper (3),
The decomposition treatment is performed by the catalyst device (54) in the hot air circulation line (D). That is, the heated air is supplied to the chamber (5).
The hydrogen peroxide gas contained in the circulating air is decomposed by a catalytic reaction while being circulated with respect to the air, so that the concentration of the hydrogen peroxide gas in the chamber (5) is always kept at a low level, and efficiently and safely. Degas the hydrogen peroxide gas. After the hydrogen peroxide gas is degassed as described above, the hot air circulation line (D) is stopped, and the processed packaging container (1) is taken out of the chamber (5) (step (S8)). .

After the degassing process, that is, after the operation of step (S7), the atmosphere may be once introduced into the chamber (5). By supplying fresh air to the chamber (5), the temperature of the inside of the chamber of the chamber (5) and the temperature of the packaging container (1) can be lowered, and handling of the subsequent process can be performed immediately. In addition, even if a small amount of hydrogen peroxide gas remains due to malfunction of the catalyst device (54) or the like, safety can be ensured by replacing the air in the refrigerator.

As described above, in the sterilization method of the present invention, the packaging container is composed of the container body (2) made of a specific material and the sterilized paper (3), and the container body (2) has the specific shape. Since the packaging container (1) provided with the packaging container (1) is used, even if the packaging container (1) is exposed to gas while being stacked in multiple stages, the contact area with the upper or lower packaging container (1) is small, and the sterilization paper ( The contact efficiency with the hydrogen peroxide gas and air in 3) can be increased, and rapid sterilization and degassing can be performed.

Then, after sterilizing with hydrogen peroxide gas, the hydrogen peroxide gas is degassed from the inside of the packaging container (1) under the condition of hot air at a predetermined temperature, so that the container body (2) Since the desorption of the hydrogen peroxide gas can be promoted, the degassing process can be performed efficiently, and the residual hydrogen peroxide gas can be reliably prevented. In addition, in the degassing treatment of the hydrogen peroxide gas, the hydrogen peroxide gas contained in the circulating air is decomposed by a catalytic reaction while circulating the heated air, so that the hydrogen peroxide gas in the chamber (5) is decomposed. Always keep the concentration lower than the inside of the packaging container (1),
Since the density difference allows the sterilized paper (3) to permeate, the hydrogen peroxide gas inside the packaging container (1) can be more efficiently degassed. Accordingly, it is possible to use a container body made of a polyester resin, which has excellent transparency and is easy to dispose of, as the container body (2).

The container body made of PET film (2)
And a sterile paper (3) composed of the above-mentioned "Tyvek" to constitute a packaging container (1), and a drug-containing syringe (4) filled with sodium hyaluronate as a drug, and a packaging container (1).
Enclosed. Then, it is divided into two processing lots (a) and (b), and using the chamber (5) shown in FIG.
Each lot was sterilized with hydrogen peroxide gas. In this case, the lot (a) is sterilized by the sterilization method of the present invention, and the lot (b) is subjected to the operations of steps (S1) to (S6) in FIG. It was left in the air for degassing. As a result, in the lot (a), the degassing process (step (S
7)), the hydrogen peroxide gas could be completely removed, whereas in lot (b), about 100 ppm of hydrogen peroxide remained in the packaging container (1) even after 6 hours.

In the present invention, in particular, the degassing operation of the hydrogen peroxide gas from the packaging container (1) by the circulation of the warm air as described above exerts remarkable effects from an industrial and environmental point of view. . That is, according to the above degassing operation, it is possible to significantly reduce the amount of air used for degassing, which may contain a small amount of hydrogen peroxide gas, to the outside of the system, and to produce hot air. The heat load required for performing this can be greatly reduced. In order to further promote the degassing effect, it is desirable to reduce the concentration of hydrogen peroxide gas in the air returned to the chamber as much as possible. In addition, hydrogen peroxide gas in the circulating air can be safely processed. In addition, since hydrogen peroxide gas is used as a sterilizing gas, it can be decomposed accurately to completely harmless components by catalytic decomposition, so it is extremely safe not only for sterilization but also for final discharge outside the system. Is secured.

[0041]

As described above, according to the sterilization method of the present invention, after sterilizing with a hydrogen peroxide gas, the hydrogen peroxide gas is degassed from the inside of the packaging container while heating. In addition, the desorption of the hydrogen peroxide gas adsorbed on the container body can be promoted. Furthermore, while circulating the heated air, the hydrogen peroxide gas contained in the circulating air is decomposed by a catalytic reaction, so that the surrounding hydrogen peroxide gas concentration is always kept lower than the inside of the packaging container, Since the sterilized paper is permeated at the concentration difference, the degassing process can be performed more efficiently, and the residual hydrogen peroxide gas can be reliably prevented. Therefore, also in medical sterilization packaging, as a container body,
It is also possible to use a container body made of a polyester resin which is excellent in transparency and easy to dispose. In particular, the degassing treatment of hydrogen peroxide gas from the packaging container by circulating hot air can be efficiently degassed as described above, and the heat load for producing hot air can be significantly reduced. The catalyst can be completely decomposed into harmless components by catalytic decomposition, and extremely high safety is ensured not only in sterilization but also in final discharge outside the system.
It has significant environmental benefits.

[Brief description of the drawings]

FIG. 1 is a process diagram showing each operation step of a sterilization method according to the present invention.

FIG. 2 is a system diagram showing an outline of a chamber as a sterilizer.

FIG. 3 is an external perspective view showing one embodiment of a packaging container in which a medicine-containing syringe is enclosed.

4 is an exploded perspective view showing the packaging structure of the packaging container in FIG. 3 from the bottom side.

FIG. 5 is a perspective view showing a method of handling a packaging container (package) in the chamber.

[Explanation of symbols]

 1: packaging container 2: container body 3: sterilized paper 4: drug-containing syringe 5: chamber 51: hydrogen peroxide gas generator 52: vacuum pump 54: catalyst device 55: circulation fan 56: heater 64: filter 81: nozzle 82: suction port 83: suction port 84: blow port

Claims (8)

[Claims] 1. A sterilization method for sterilizing a medical product sealed in a packaging container with hydrogen peroxide gas, wherein the packaging container includes a container body made of a synthetic resin having a gas barrier property, and a hydrogen peroxide gas. Using a container that is permeable and sterilized paper as a lid material that can be welded to the container body, and after sterilizing with hydrogen peroxide gas,
A method for sterilizing medical sterile packaging, comprising degassing hydrogen peroxide gas from the inside of a packaging container while heating. 2. A method for sterilizing a medical product enclosed in a packaging container in a chamber as a sterilizing device, and circulating heated air to the chamber, while hydrogen peroxide contained in the circulating air. The sterilization method according to claim 1, wherein the hydrogen peroxide gas is degassed by decomposing the gas by a catalytic reaction. 3. The sterilization method according to claim 2, wherein after degassing, air is introduced into the chamber. 4. The sterilization method according to claim 2, wherein the sterilization treatment is performed by repeating an operation of supplying hydrogen peroxide gas to the decompressed chamber a plurality of times. 5. A hydrogen peroxide gas supply line, a pressure reduction line, an air introduction line and a hot air circulation line are provided as a chamber, and the hydrogen peroxide gas is supplied to the pressure reduction line and the hot air circulation line. The sterilization method according to any one of claims 2 to 4, wherein a chamber provided with a catalyst device for decomposition is used. 6. The medical product according to claim 1, wherein the medical product is a syringe containing a medicine.
The sterilization method according to any one of claims 1 to 5, wherein 7. The sterilization method according to claim 6, wherein the drug filled in the drug-containing syringe is a sodium hyaluronate solution. 8. The sterilization method according to claim 7, wherein the method is heated to 30 to 120 ° C.