JP4164890B2 - Injection pack - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to an injectable pack, and more particularly, an injectable pack in which a medicine-filled syringe is enclosed in a packaging container, which is sealed with sterilized paper that mainly transmits only sterilized gas, and The present invention relates to an injectable pack using a packaging container in a form that allows easy sterilization of a contained medicine-filled syringe.
[0002]
[Prior art]
Similarly to disposable medical devices, medicine-filled syringes are distributed as so-called injection packs that are sterilized for medical use by a specific packaging container. The packaging container is composed of a container body integrally formed of a transparent resin and having a bottom surface opened, and a sterilized paper made of a sheet material that is permeable to sterilization gas and sealing the bottom surface of the container body. . And the inside of the packaging container in which the syringe containing a medicine is enclosed is sterilized by the gas which permeate | transmitted the sterilization paper by exposing to ethylene oxide gas, for example. In addition, from the viewpoint of processing efficiency, such sterilization processing is usually performed in a state where a large number of sterilization processes are arranged and stacked in a number of stages.
[0003]
[Problems to be solved by the invention]
By the way, when sterilization is performed in a state where many injection packs are stacked one above the other, since the surface of the sterilized paper is covered with the container body of the upper or lower packaging container, the transmission efficiency of the sterilized gas in the sterilized paper is reduced. Problems arise. Further, after the sterilization treatment, it is necessary to sufficiently remove the sterilization gas so that there is no residue, but there is a problem that the deaeration efficiency of the gas that has penetrated into the inside of the packaging container is low.
[0004]
The present invention has been made to further improve the efficiency of the above-described sterilization treatment, and an object thereof is an injection pack in which a medicine-filled syringe is enclosed in a packaging container, which is sealed with sterile paper, And it is providing the injection pack which uses the packaging container of the form with which the sterilization of the accommodated syringe with a medicine is easy.
[0005]
[Means for Solving the Problems]
In order to solve the above-mentioned problems, the injection pack of the present invention is an injection pack in which a syringe containing a medicine is enclosed in a packaging container, and the packaging container is a long and narrow container made of a transparent polyester resin. And a sterilized paper made of a sheet material that is permeable to sterilizing gas and sealing the bottom surface of the container body. The container body contains a medicine. Accommodates a first bulging portion that accommodates a syringe needle mounting portion of a syringe barrel of a syringe, a second bulging portion that accommodates a substantially central portion of a syringe containing a medicine, and a flange of a syringe barrel and a pusher for a piston rod A third bulging portion and two constricted portions that connect the bulging portions, and the first bulging portion and the third bulging portion are sterilized during sterilization. It forms a storage space of the gas, the second Rise Parts, the formed by the first protruding portion and the third swelled portion lower height than the said third bulging portion, when seen from the side from the longitudinal side of the container body, the central portion It is formed in the shape of a recessed collar.
[0006]
The above-mentioned injection pack is sterilized in a state where a number of layers are stacked in the vertical direction. In that case, each constriction part of a container main body forms a clearance gap between the upper or lower packaging containers, and distributes sterilization gas through the whole laminated body of an injection pack. And since the largest 3rd bulging part which accommodates the flange of the injection cylinder of a syringe with a medicine, and the pusher of a piston rod is formed in the collar part shape in which the center part was dented, the upper or lower packaging container And the contact efficiency of the sterilizing gas in the sterilized paper of the packaging container is increased.
[0007]
In the injection pack having the above-described configuration, the height of the second bulging portion is the first height in order to further reduce the contact area between the container body and the sterilized paper of the other packaging container in the stacked state. It is preferable that the bulge portion and the third bulge portion are formed lower.
[0008]
DETAILED DESCRIPTION OF THE INVENTION
One embodiment of an injection pack according to the present invention will be described with reference to the drawings. FIG. 1 is a perspective view showing an outer shape of a packaging container in an injection pack. FIG. 2 is an exploded perspective view showing the packaging structure of the injection pack from the bottom side. FIG. 3 is a diagram showing the shape of the bulging portion of the packaging container, and is a cross-sectional view orthogonal to the longitudinal direction of the container body. FIG. 4 is a perspective view showing an embodiment of the sterilization treatment of the injection pack.
[0009]
The injection pack of the present invention is configured by accommodating a medicine-filled syringe (4) in a packaging container (1), as indicated by reference numeral (P) in FIGS. As is well known, the medicine-filled syringe (4) is a syringe that can be used immediately after the injection needle is attached. The syringe (41) is provided with a cap (42) attached to the injection needle attachment portion, and a piston is provided at the tip. And a piston rod (44) inserted into the syringe barrel (41) and a medicine filled in the syringe barrel (41). A technique related to a medicine-filled syringe is described in JP-A-4-150868.
[0010]
The injection pack (P) is a form of medical sterilization packaging that uses sterilization gas and sterilizes the inside of the container without heating. As a medicine filled in the medicine-filled syringe (4), heating is used. Unsuitable drugs, typically sodium hyaluronate solution and the like are suitable. Further, as the sterilizing gas, a gas having low toxicity is desirable from the viewpoint of handling in the treatment process, and hydrogen peroxide gas is a suitable gas because it has a sterilizing action and is relatively low in toxicity as compared with ethylene oxide gas. is there.
[0011]
As shown in FIG. 1, the packaging container (1) includes a container body (2) integrally formed into a thin and substantially container shape with a transparent resin and an open bottom surface, and a sheet material that is permeable to sterilization gas. And sterilized paper (3) for sealing the bottom surface of the container body (1). As a resin material constituting the container body (2), an appropriate thermoplastic resin can be used as long as it is a material that does not allow bacteria to permeate and allows the contents to be visually observed. From the viewpoint of gas barrier properties and transparency, The container body (2) is preferably made of a polyester-based resin such as polyethylene terephthalate (PET) or polybutylene terephthalate.
[0012]
Specifically, the container body (2) is manufactured by a molding method such as blister molding or deep drawing using a polyethylene terephthalate film having a thickness of 200 to 600 μm. In particular, the container body (2) made of a PET film does not generate a toxic gas such as chlorine like vinyl chloride at the time of disposal, and is a preferable packaging material from the viewpoint of pollution prevention.
[0013]
As the sheet material constituting the sterilized paper (3), a material that does not permeate microorganisms such as bacteria and is permeable to gas such as sterilization gas or air, for example, a product name “Tyvek 1073B” manufactured by DuPont. A known high density polyethylene sheet material is preferably used. Such sterilized paper (3) is welded to the container body (2) by an ultrasonic welding method or a heat welding method.
[0014]
In the injection pack (P) of the present invention, the container body (2) is a first container that houses the tip of the syringe barrel (41) of the syringe (4) containing a medicine, that is, the syringe needle mounting portion on which the cap (42) is mounted. A second bulging portion (22) for accommodating a substantially central portion of the entire length of the medicine-filled syringe (4) including the piston rod (44) inserted partway, and a syringe barrel ( 41) a flange (43) and a piston rod (44) pusher (terminal enlarged diameter portion) (45), and a third bulge portion (23) for accommodating the bulge portions. Constricted portions (24) and (24) are provided.
[0015]
That is, the first bulging portion (21) and the third bulging portion (23) of the container body (2) form a relatively large space on both ends of the medicine-filled syringe (4), and the syringe barrel ( 41) and a function of temporarily storing sterilizing gas diffusing into the details of the medicine-filled syringe (4) such as a gap between the piston rod (44). The central second bulging portion (22) functions as a bending fulcrum of the container body (2) for easily and hygienically removing the medicine-filled syringe (4) from the packaging container (1).
[0016]
In addition, each constricted portion (24) of the container body (2) has a gap between the upper and lower injection packs (P) when a large number of injection packs (P) are stacked in a sterilization process to be described later. Form and improve the flow of sterilization gas and air. Furthermore, from such a viewpoint, the first bulging portion (21) and the third bulging portion (23) of the container body (2) are configured as support points when stacked, and the second bulging portion (22) is preferably formed at a lower height than the first bulge portion (21) and the third bulge portion (23).
[0017]
Furthermore, as shown in FIG. 3, the first bulging portion (21), the second bulging portion (22), and the third bulging portion (23) are formed when the injection packs (P) are stacked. In order to improve the flow of sterilization gas and air and reduce the contact area of the upper or lower injection pack (P) with the sterilized paper (3), the curvature radius (R) of the corners is in the range of 5 to 20 mm. Set by.
[0018]
The greatest feature of the present invention is that the third bulging portion (23) is formed in a specific shape in the container body (2). That is, in order to secure a sufficient effective gas permeation area of the sterilized paper in the sterilization treatment of the injection pack (P), the third bulging portion (23) of the container body (2) is formed in the longitudinal direction of the container body (2). When viewed from the side, it is formed in the shape of a collar with a recessed central portion. Specifically, as shown in FIG. 1, the third bulging portion (23) has protruding portions on the front and rear along the longitudinal direction of the container body (2), and a collar portion ( 25).
[0019]
As shown in FIG. 2, the injection pack (P) is filled with a syringe (4) containing a medicine in a molded container body (2), and then sterilized paper (3) is welded to the bottom surface of the container body (2). Thus, the medicine-filled syringe (4) is enclosed in the packaging container (1). An adapter (auxiliary tool) (47) is attached to the flange (43) of the syringe barrel (41) of the syringe (4) containing the drug shown in FIG. Yes. The adapter (47) has a shape in which two annular thin plates are opposed to each other through a gap. The adapter (47) also has a function of preventing the medicine-filled syringe (4) from swinging when the medicine-filled syringe (4) is accommodated in the container body (2). In addition, a container main body (2) is shape | molded in the state where several in the horizontal direction was continued on manufacturing efficiency, and several injection pack (P) is manufactured simultaneously.
[0020]
The sterilization process is performed by loading a large number of injection packs (P) on a cart, loading the cart together with a closed system chamber, and supplying a sterilization gas such as hydrogen peroxide gas to the chamber. In the sterilization process, the injection pack (P) is exposed to hydrogen peroxide gas in a state in which a large number of injection packs (P) are arranged (for example, only one row is illustrated) and stacked in a number of stages vertically.
[0021]
At that time, in the injection pack (P) of the present invention, the constricted portion (24) of the container body (2) forms a gap with the upper or lower packaging container (1). Hydrogen peroxide gas is circulated through the entire laminate of P). Then, the largest third bulge portion (23) of the container body (2) that accommodates the flange (43) of the syringe barrel (41) of the medicine-filled syringe (4) and the pusher (45) of the piston rod (44). ) Is formed in the shape of a saddle with a recessed central part, so that the contact area with the upper or lower packaging container (1) is small, and the hydrogen peroxide gas in the sterilized paper (3) of the packaging container (1) Increase contact efficiency.
[0022]
In addition, after sterilization, the hydrogen peroxide gas in the chamber is evacuated, and the injection pack (P) is exposed to the introduced air to degas the hydrogen peroxide gas inside the packaging container (1). . At that time, as in the sterilization process, the constricted portion (24) of the container body (2) allows air to flow through the entire laminate of the injection pack (P), and the third bulging portion (23) Enhance air contact efficiency in sterile paper (3).
[0023]
That is, in the injection pack (P) of the present invention, the container body (2) of the packaging container (1) has the specific shape as described above, and the gas permeation of the sterilized paper (3) when stacked. Since the area can be secured sufficiently, hydrogen peroxide gas can be permeated into the packaging container (1) in a short time during sterilization, and hydrogen peroxide gas can be degassed from the inside of the packaging container (1) in a short time. it can. Therefore, in the injection pack (P) of the present invention, the sterilization efficiency can be further improved.
[0024]
【The invention's effect】
As described above, according to the injection pack of the present invention, the container main body of the packaging container includes the three bulging portions and the two constricted portions that connect them, and the third bulging portion is the center. It has a saddle-like shape with the recessed parts, and it can secure a sufficient gas permeation area of sterilized paper when stacked, so that sterilization gas can permeate into the packaging container in a short time during sterilization, The sterilization gas can be degassed from the inside of the packaging container in a short time, and as a result, the efficiency of the sterilization process can be further improved.
[Brief description of the drawings]
FIG. 1 is a perspective view showing an outer shape of a packaging container in an injection pack. FIG. 2 is a developed perspective view showing a packaging structure of the injection pack from the bottom. FIG. 3 is a cross section showing a shape of a bulging portion of the packaging container. [Fig. 4] Perspective view showing the mode of sterilization of injection pack [Explanation of symbols]
1: packaging container 2: container main body 21: first bulging part 22: second bulging part 23: third bulging part 24: constricted part 25: collar part 3: sterilized paper 4: syringe with medicine 41: Injection cylinder 43: Flange 44: Piston rod 45: Pusher P: Injection pack

Claims (4)

An injection pack in which a medicine-filled syringe is enclosed in a packaging container, wherein the packaging container is integrally formed into a thin and substantially container shape with a transparent polyester resin, and the bottom of the container body is sterilized. And a sterilized paper that seals the bottom surface of the container body, and the container body contains a first bulge for housing a syringe needle mounting portion of a syringe containing a medicine. Combining these bulges with the bulge, the second bulge that accommodates the substantially central portion of the syringe containing the medicine, the third bulge that accommodates the flange of the syringe barrel and the pusher of the piston rod to a 2 constriction, and the first protruding portion and the third bulging portion forms a reservoir space of the sterilizing gas at the time of sterilization, the second Rise From the first bulging portion and the third bulging portion, the protruding portion is Low formed height, the third bulging portion, when seen from the side from the longitudinal side of the container body, injection packs, characterized in that the central portion is formed in a saddle shape with recessing. The injection pack according to claim 1 , wherein the polyester resin is polyethylene terephthalate or polybutylene terephthalate. The injection pack according to claim 1 or 2 , wherein the inside of the packaging container is sterilized with hydrogen peroxide gas in a state in which the medicine-filled syringe is housed and the bottom surface of the container body is sealed with sterilized paper. The injection pack according to any one of claims 1 to 3, wherein a sodium hyaluronate solution is filled as a drug in a syringe containing the drug.

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