JPH11180821A - Emulsion lotion for keeping moisture of skin containing sulfated polysaccharides - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prepare an oil-in-water type emulsion lotion containing sulfated polysaccharides and/or salts thereof, excellent in stability of the emulsion and sustainability of efficacy that is maintenance of moisture preservation of the skin. SOLUTION: This oil-in-water type emulsion lotion contains sulfated polysaccharides and/or salts thereof, and an emulsion stabilizer. A sulfated product of a mucopolysaccharide, a chitin, a starch, a cellulose, a guar gum, a gum arabic, konjakmannan, an agar agarose or an amylopectin is used as the sulfated polysaccharides, and a polysulfate of chondroitin is preferable.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an oil-in-water emulsion lotion which is useful as pharmaceuticals, quasi-drugs and cosmetics.

[0002]

2. Description of the Related Art In general, a lotion is defined as a liquid external preparation which is prepared by dissolving an active ingredient in an aqueous liquid or finely and uniformly dispersed and applied to the skin (Japanese Pharmacopoeia). It is called a suspension lotion, emulsion lotion or solution lotion. In particular, emulsion lotions are sometimes referred to as emulsions, and oil-in-water emulsions are preferred because of their good feel.
The oil-in-water emulsion lotion is an emulsified system like the oil-in-water emulsion ointment (cream), and thus basically comprises an oil component, an aqueous component and a surfactant (emulsifier). However, even with the same emulsifying system, it is considered difficult to stabilize the emulsion lotion because the external phase (aqueous phase) is not solidified. As a solution to this problem, a method of increasing the viscosity of the external phase is known, and a method of adding a water-soluble polymer represented by carboxyvinyl polymer, hydroxypropylcellulose, etc. as a thickener (water-soluble polymer (1973) Nakamura Ed., Chemical Industry Co., Ltd.).

On the other hand, as a preparation containing a sulfated polysaccharide or a salt thereof, a skin humectant containing a polysulfate ester of chondroitin sulfate as an active ingredient (JP-B-62-43)
No. 62) is known, and in this patent, dosage forms of detergents, creams, lotions, oscilloscopes and lipsticks are mentioned. In this patent, those classified as lotions according to today's dosage form classification include plant lotion, alkaline lotion, astringent end lotion, and hand lotion, which are classified as lotions. , An emulsion, a foundation lotion and a cleansing lotion, but mainly a solution lotion which does not require an emulsion stabilizing technique in an oil-in-water emulsion lotion. In addition, no particular mention is made of the stability of emulsions, that is, emulsion lotions.

An emulsion lotion containing a sulfated polysaccharide such as chondroitin sulfate polysulfate or a salt thereof is stabilized by the above-mentioned emulsion stabilization method, that is, by adding a water-soluble polymer. Can be considered. However, according to the present inventors, sulfated polysaccharides or salts thereof are apt to inhibit the thickening effect of other water-soluble polymers, despite being one kind of water-soluble polymer, It has been found that it is difficult to stabilize an emulsion by an oil-in-water emulsion lotion containing a polysaccharide or a salt thereof by such a method.

In general, emulsion lotions are
Compared with other external preparations (oil-based ointments and emulsion-based ointments), the amount of oily components to be blended is small, so that it has an excellent feeling in use and at the same time has the advantage of less feeling of remaining on the skin. However, it is said that there is a problem in sustaining efficacy due to poor skin coverage.

[0006]

SUMMARY OF THE INVENTION An object of the present invention is to provide an oil-in-water emulsion lotion which is excellent in the stability of the emulsion and the sustainability of the efficacy, that is, the skin moisturizing property. .

[0007]

Means for Solving the Problems As a result of intensive studies to solve the above problems, the present inventors have found that reduced lanolin is used in an oil-in-water emulsion lotion containing a sulfated polysaccharide or a salt thereof. By blending such an emulsion stabilizer, it has been found that an oil-in-water emulsion lotion having excellent skin moisturizing effect can be obtained while ensuring the stability of the emulsion. Reached.

That is, the present invention relates to: 1. An oil-in-water emulsion lotion containing a sulfated polysaccharide and / or a salt thereof and an emulsion stabilizer, and 2. An item according to claim 1, wherein the emulsion stabilizer is reduced lanolin. Item 3. Oil-in-water emulsion lotion, Item 3. The sulfated polysaccharide is a polysulfate of mucopolysaccharide.
Or an oil-in-water emulsion lotion according to any one of items 2 to 4, wherein the sulfated polysaccharide is a heparin-like substance.
Item 5. An oil-in-water emulsion lotion according to any one of Items 1 to 4, wherein the sulfated polysaccharide is a polysulfate ester of chondroitin sulfate. Item 6. Similar to heparin The present invention relates to an oil-in-water emulsion lotion containing a substance, reduced lanolin and a carboxyvinyl polymer.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, the sulfated polysaccharides are mainly composed of D-glucosamine, D-galactosamine, D-glucuronic acid, L-iduronic acid,
-A sulfated polysaccharide obtained by sulfating a polymer comprising glucose, D-galactose and D-xylose and having one or more of the monosaccharides as repeating units.

The sulfated polysaccharides of the present invention also include polysaccharides already having a sulfate group in nature and those obtained by further artificially sulfating polysaccharides already having a sulfate group in nature. It is.

Further, the sulfated polysaccharide of the present invention includes a heparin-like substance which is a high-molecular substance having an anticoagulant effect, and the heparin-like substance is a high-molecular substance which is not constituted by sugar. Those having similar properties are also included.

Specific examples of the sulfated polysaccharide in the present invention include sulfates of mucopolysaccharides such as heparin, chondroitin, and hyaluronic acid; and chondroitin sulfate D and chondroitin sulfate E called chondroitin polysulfate; Mucopolysaccharide already having a sulfate group; polysulfate obtained by further sulfated polysaccharide having a sulfate group in nature as described above; sulfate of chitin; starch, cellulose, guar gum, gum arabic Konjac mannan, agar agarose, amylopectin sulfate and the like.

Among these sulfated polysaccharides, the sulfated polysaccharide used in the present invention is preferably sulfated mucopolysaccharide (including mucopolysaccharide already having a sulfate group in nature and further sulfated). Particularly, polysulfate of chondroitin sulfate is preferred.

As described above, the sulfated polysaccharide of the present invention contains a heparin-like substance. Heparin-like substances (heparinoids) include cellulose sulfate, chitin sulfate, chitosan sulfate, pectin sulfate, chondroitin sulfate, inulin sulfate, alginate sulfate, glycogen sulfate, starch sulfate, polyvinyl alcohol sulfate, polyglucose sulfate, polylactose sulfate, laminarin sulfate , Galactan sulfate, levan sulfate and their polysulfates and salts thereof.

In this specification, unless otherwise specified, the term "heparin analog" simply means the above-mentioned heparin analog.

Examples of the sulfated polysaccharide salts include alkali metal salts such as sodium salt and potassium salt, alkaline earth metal salts such as calcium and magnesium, and the like, and a plurality of these salts are also included.

The number of sulfate groups contained in the sulfated polysaccharide is 0.55 to 5 on average per repeating sugar unit, preferably 0.7 to 2 on average. In addition, when the polysaccharide is a mucopolysaccharide already having a sulfate group before sulfation such as chondroitin polysulfate, the number of sulfate groups contained in the sulfated polysaccharide is an average per repeated sugar unit. 0.55 to 5,
Preferably, the average is 0.6 to 2.9, more preferably the average
0.7 to 2.

The average molecular weight of the sulfated polysaccharide or a salt thereof is as follows:
It is desirable to be about 1,000 to 10,000,000, preferably about 5,000 to 1,000,000, more preferably 10,000 to
Desirably about 100,000.

In the oil-in-water emulsion lotion of the present invention, these sulfated polysaccharides or salts thereof may be used alone or in combination.

The above-mentioned sulfation reaction for introducing a sulfate group into the polysaccharide is carried out, for example, as follows.

First, an ice-cooled solvent is prepared, and a sulfating agent is added thereto. The raw material polysaccharide is added to the mixture,
Sulfation is performed by reacting at 100 ° C. for 1 to 10 hours.

The amount of the solvent used may vary depending on the kind of the starting polysaccharide used, the target sulfated polysaccharide, and the like, but is preferably 10 to 30 mL per gram of the starting polysaccharide. The amount of the sulfating agent to be used can be appropriately selected according to the type of the raw material polysaccharide to be used and the intended sulfated polysaccharide. For example, 2 to 6 g can be used for 1 g of the raw material polysaccharide.

The solvent to be used is not particularly limited and can be appropriately selected depending on the kind of the raw material polysaccharide to be used and the target sulfated polysaccharide, and for example, pyridine, N, N-dimethylformamide, N, N-dialkylacrylamide and the like can be used.

The sulfating agent is not particularly limited as long as the objective sulfated polysaccharide can be obtained in the same manner as described above, but chlorosulfonic acid, triethylamine-sulfatrioxide complex salt and the like can be used.

The concentration of the sulfated polysaccharide or salt thereof in the oil-in-water emulsion lotion is not particularly limited as long as the effects of the present invention can be obtained. % To 1.0% by weight, preferably 0.1% to 1.0% by weight.
% By weight is more preferable, and particularly preferable is 0.2% by weight to 0.4% by weight.

In the present invention, the term "emulsion stabilizer" refers to, for example, an emulsion of a water-in-oil type emulsion lotion free of sulfated polysaccharide by a generally known stabilization method. And an oil-in-water emulsion lotion containing a sulfated polysaccharide, which can stabilize the emulsion.

Examples of the emulsion stabilizer in the present invention include reduced lanolin.

[0028] Reduced lanolin is another name for hydrogenated lanolin, and is obtained by hydrogenating (reducing) lanolin. Since the fatty acids constituting lanolin are also reduced to alcohol upon reduction, the reduced lanolin is a mixture of an alcohol obtained by hydrogenating higher alcohols constituting lanolin and an alcohol obtained by hydrogenating the fatty acid.

Further, the emulsion stabilizer of the present invention does not include a component which is blended with a general oil-in-water emulsion lotion currently marketed to stabilize the emulsion.

The concentration of the emulsion stabilizer in the oil-in-water emulsion lotion is not particularly limited as long as it can stabilize the sulfated polysaccharide. It is preferably from 0.05% by weight to 15.0% by weight, more preferably from 0.1% by weight to 5.0% by weight.

In the present invention, the blending ratio (weight) of the sulfated polysaccharide or a salt thereof and the emulsion stabilizer is 20: 1 to 1:
300.

The oil-in-water type emulsion lotion of the present invention may contain, in addition to the above-mentioned sulfated polysaccharide and / or salt thereof and an emulsion stabilizer, components usually contained for forming an oil-in-water type emulsion lotion. That is, it contains a surfactant, an oil-soluble substance, and a water-soluble substance.

Examples of the surfactant include a cationic surfactant, an anionic surfactant, an amphoteric surfactant and a nonionic surfactant, and these can be used alone or in combination.

The use amount of these surfactants is not particularly limited as long as they function as an emulsifier.
It is preferably from 0.2% by weight to 5.0% by weight based on the total amount of the oil-in-water emulsion lotion. Furthermore, since the oil-in-water emulsion lotion of the present invention is used for pharmaceuticals, cosmetics and the like, it is preferable to use a nonionic surfactant as a main component as little as possible among these surfactants.

Specific examples of the cationic surfactant which can be used in the present invention include, for example, cetyltrimethylammonium chloride, lauryldimethylbenzylammonium chloride, tetrabutylammonium chloride,
And dioctadecyldimethylammonium chloride.

Examples of the anionic surfactant include sodium alkylbenzene sulfonate, sodium dodecyl sulfate, sodium coco alcohol ethoxy sulfate, α
-Sodium olefin sulfonate and the like.

Examples of the nonionic surfactant include polyoxyethylene alkyl ether, polyoxyethylene alkyl phenol ether, sorbitan fatty acid ester,
Examples include glycerin fatty acid esters and sucrose fatty acid esters.

Examples of the amphoteric surfactant include N-alkyl-N, N-dimethylammonium betaine and imidazoline type amphoteric surfactants.

The oil-soluble substance used in the oil-in-water emulsion lotion of the present invention can be used without particular limitation as long as it is an oil-soluble substance used in the fields of pharmaceuticals, cosmetics and the like. hydrocarbon,
Examples include oils and fats, waxes, fatty acids, higher alcohols, and ester oils. These oil-soluble substances can be appropriately combined and blended according to the purpose of use.

Examples of the hydrocarbon include liquid paraffin, squalane, synthetic squalane, white petrolatum, ceresin wax, solid paraffin, and microstalin wax.

Examples of fats and oils include olive oil, soybean oil, camellia oil, palm oil, castor oil and the like.

Specific examples of waxes include beeswax, carnauba wax, mokuro, liquid lanolin, hard lanolin and the like.

Examples of the fatty acid include lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid and the like.

Examples of higher alcohols include lauryl alcohol, stearyl alcohol, cetostearyl alcohol, cetanol, octyldodecanol, hexyldecanol, lanolin alcohol and the like.

Examples of the esters include cetyl lactate, isopropyl myristate, octyl dodecyl myristate and the like.

The amount of the oil-soluble substance to be used can be appropriately changed depending on the intended use, desired feeling of use, and the like, and is not particularly limited. However, considering the feel, the amount of the oil-soluble substance is 1 to the total amount of the oil-in-water emulsion lotion. 0.0-30% by weight or less is preferred.

The water-soluble substance in the present invention is not particularly limited as long as it is a water-soluble substance usually used in an oil-in-water emulsion lotion, such as water, a humectant, a thickener and a pH adjuster. And can be combined in an appropriate combination according to the purpose of use.

Examples of the humectant include ethylene glycol, propylene glycol, 1,3-butylene glycol, hexylene glycol, diethylene glycol, glycerin, diglycerin, sodium pyrrolidonecarboxylate, sodium lactate, glucose, maltose, xylitol and sorbitol. No.

Examples of the thickener include carboxyvinyl polymer, carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, carrageenan, xanthan gum, gelatin and the like.

Examples of the pH adjuster include diisopropanolamine, triisopropanolamine, triethanolamine, potassium hydroxide, sodium hydroxide,
Examples include sodium citrate, phosphoric acid, tartaric acid, dl-malic acid, glacial acetic acid and the like.

The amount of the water-soluble substance to be used can be appropriately changed depending on the intended use, desired feeling of use, and the like, and is not particularly limited, but is preferably 60 to the total amount of the oil-in-water emulsion lotion.
It is preferred to use up to 95% by weight.

The oil-in-water emulsion lotion may further contain an oil-soluble or water-soluble substance other than those described above, which is commonly used in cosmetics and pharmaceuticals, as long as the effects of the present invention are not impaired. can do. For example, known ingredients such as preservatives, sequestering agents, ultraviolet absorbers, drugs, dispersants, and the like used for cosmetics and pharmaceuticals can be blended.

[0053]

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples, but the present invention is not limited to these Examples.

Example 1 An oil-in-water emulsion lotion having the following composition was prepared.

(% By weight) (1) squalane 4.00 (2) cetanol 0.50 (3) reduced lanolin 1.00 (4) octyldodecyl myristate 2.00 (5) salami beeswax 0.50 (6) polyoxyethylene (23) cetyl ether 1.00 ( 7) Glycerin monostearate 1.00 (8) Carboxyvinyl polymer 0.20 (9) Diisopropanolamine 0.20 (10) Glycerin 15.00 (11) Heparin-like substance 0.30 (12) Purified water 74.30 (1) to (7) are weighed in a container The mixture was heated to about 75 ° C. to prepare an oil phase which was stirred and dissolved. (8)-(1)
2) was weighed, heated to about 75 ° C., and stirred and dissolved to prepare an aqueous phase.

An aqueous phase was added to the prepared oil phase, and the mixture was uniformly emulsified with a homomixer and then cooled to room temperature to prepare an oil-in-water emulsion lotion of the present invention.

The heparin-like substance in the above formulation is
Heparin-like substance defined in the Japanese Pharmacopoeia Non-Pharmaceutical Standards, and the same applies to the following Examples and Comparative Examples. The heparin-like substance defined in the Japanese Pharmacopoeia Non-Pharmaceutical Standards mainly contains a polysulfate ester of chondroitin sulfate.

Comparative Example 1 An oil-in-water emulsion lotion was prepared in the same manner as in Example 1 except that the reduced lanolin and the heparin-like substance were omitted from the composition of Example 1.

Comparative Example 2 Example 1 was repeated except that reduced lanolin was omitted from the composition of Example 1.
An oil-in-water emulsion lotion was prepared in the same manner as described above.

Example 2 An oil-in-water emulsion lotion having the following composition was prepared.

(% By weight) (1) squalane 3.30 (2) cetanol 0.40 (3) reduced lanolin 0.80 (4) polyoxyethylene (60) hydrogenated castor oil 1.70 (5) carboxyvinyl polymer 0.25 (6) diisopropanolamine 0.20 (7) Glycerin 12.00 (8) 1,3-butylene glycol 2.50 (9) Heparin analog 0.30 (10) Purified water 78.55 (1) to (4) are weighed into a container and heated to about 75 ° C,
An oil phase dissolved by stirring was prepared. (5)-(1)
0) was weighed, heated to about 75 ° C., and stirred and dissolved to prepare an aqueous phase.

An aqueous phase was added to the prepared oil phase, and the mixture was uniformly emulsified with a homomixer and then cooled to room temperature to prepare an oil-in-water emulsion lotion of the present invention.

Comparative Example 3 An oil-in-water emulsion lotion was prepared in the same manner as in Example 2, except that the reduced lanolin and the heparin-like substance were omitted from the composition of Example 2.

Comparative Example 4 Example 2 was repeated except that the reduced lanolin was omitted from the composition of Example 2.
An oil-in-water emulsion lotion was prepared in the same manner as described above.

Example 3 An oil-in-water emulsion lotion having the following composition was prepared.

(% By weight) (1) Squalane 4.00 (2) Cetanol 0.80 (3) Reduced lanolin 1.00 (4) Polyoxyl stearate 40 2.50 (5) Glycerin monostearate 1.50 (6) Carboxyvinyl polymer 0.15 (7) Di Isopropanolamine 0.15 (8) Glycerin 5.00 (9) Heparin analog 0.30 (10) Purified water 84.60 (1) to (5) are weighed into a container and heated to about 75 ° C,
An oil phase dissolved by stirring was prepared. (6)-(1)
0) was weighed, heated to about 75 ° C., and stirred and dissolved to prepare an aqueous phase. The aqueous phase was added to the prepared oil phase, uniformly emulsified with a homomixer, and then cooled to room temperature to prepare an oil-in-water emulsion lotion of the present invention.

Comparative Example 5 An oil-in-water emulsion lotion was prepared in the same manner as in Example 3 except that the reduced lanolin and the heparin-like substance were omitted from the composition of Example 3.

Comparative Example 6 Example 3 was repeated except that the reduced lanolin was omitted from the composition of Example 3.
An oil-in-water emulsion lotion was prepared in the same manner as described above.

Comparative Example 7 An oil-in-water emulsion-type lotion containing mucopolysaccharide sulfate containing no reduced lanolin was used as the oil-in-water emulsion lotion of Comparative Example 7.

[Emulsion Stability Test] An emulsion stability test was performed on the oil-in-water emulsion lotions of Examples 1 to 3 and Comparative Examples 1 to 7.

The emulsion stability test was carried out by sealing a 15 ml screw vial filled with the preparation prepared as described above and about 5 g of a commercially available preparation, followed by storing in a 50 ° C. thermostat for 2 weeks. Thereafter, the sample was taken out of the thermostat, centrifuged at 3,000 rpm at room temperature, and the state of water separation from the preparation was visually observed. Table 1 shows the results of the emulsion stability test.

[0072]

[Table 1]

Comparative Example 1, which is an oil-in-water type emulsion lotion containing no heparin analog, which is a sulfated polysaccharide,
The emulsification stability in Comparative Example 3 and Comparative Example 5 was very high (no water separation was observed at all), and the result that the emulsification stabilizing effect by the thickening effect of the added water-soluble polymer (carboxyvinyl polymer) was confirmed. Met.

On the other hand, the emulsification stability of Comparative Examples 2, 4 and 6 in which a sulfated polysaccharide was added to each of the lotions of Comparative Examples 1, 3 and 5 (low water separation) Is observed-clear water separation is observed), and it has been found that the thickening effect of the water-soluble polymer and its emulsion stabilizing effect are inhibited by the incorporated sulfated polysaccharide.

However, the emulsification stability in Examples 1, 2 and 3 which are oil-in-water emulsion lotions containing reduced lanolin and sulfated polysaccharides is very high (no water separation is observed at all). ), Reduced lanolin was found to be effective in improving the emulsion stability of an oil-in-water emulsion lotion containing a sulfated polysaccharide.

Further, as a result of examining the emulsion stability of the commercially available oil-in-water emulsion lotion containing the mucopolysaccharide polysulfoxide of Comparative Example 7, the emulsion stability was insufficient (slight water separation). Admit). This result is shown in Comparative Example 7
Shows that the emulsification stability is not sufficient because the reduced lanolin is not blended.

[Moisturizing Effect Test I] 0.3% sulfated polysaccharide-containing oil-in-water emulsion lotion administration group containing 0.3% sulfated polysaccharide, 0.3% sulfated polysaccharide-free oil-in-water emulsion lotion administration group, 0.3%
% Water content of oil-in-water emulsion ointment (cream) containing 4% sulfated polysaccharide and the untreated group were measured for the moisture content of the epidermal stratum corneum in experimentally dried skin of guinea pigs, evaluated. Skin surface stratum corneum moisture content, skin surface hygrometer (SKIN SURFACEHYGROMETER)
Was measured as high-frequency conductivity. In the above lotion, a heparin-like substance defined in the Japanese Pharmacopoeia Non-Pharmaceutical Standard was used as the sulfated polysaccharide. The same applies to the following lotions.

FIG. 1 shows the results.

The oil-in-water emulsion lotion administration group containing 0.3% sulfated polysaccharide of the present invention has higher skin moisturization than the oil-in-water emulsion lotion administration group without sulfated polysaccharide and the untreated group. The effect was shown. Furthermore, the group administered with the oil-in-water emulsion lotion containing 0.3% sulfated polysaccharide showed the same skin moisturizing effect as the group administered with the oil-in-water emulsion ointment (cream) containing 0.3% sulfated polysaccharide. .

[Moisturizing Effect Test II] 0.3% sulfated polysaccharide-containing oil-in-water emulsion lotion administration group of the present invention.
3% sulfated polysaccharide-containing solution lotion administration group, 10%
For the four groups of the urea-containing oil-in-water emulsion lotion administration group and the untreated group, the moisture content of the epidermal stratum corneum in experimental dry skin of guinea pigs was measured in the same manner as in the above moisturizing effect I, and the moisturizing effect was evaluated.

FIG. 2 shows the results.

The oil-in-water emulsion lotion-containing group containing 0.3% sulfated polysaccharide of the present invention comprises an untreated group, a group administered with a 0.3% sulfated polysaccharide-containing solution lotion and an oil-in-water lotion containing 10% urea. It showed a higher skin moisturizing effect than each group of the emulsion type lotion administration group.

From the results of the above-mentioned emulsion stability test and moisturizing effect test, the product of the present invention in which reduced lanolin was blended with an oil-in-water emulsion lotion containing a sulfated polysaccharide or a salt thereof showed an improvement in the stability of the emulsion. It was found to be excellent and the skin moisturizing effect was superior to the solution lotion and equivalent to that of the emulsion ointment (cream).

It is expected that a similar effect can be obtained by adding a substance similar to reduced lanolin to an oil-in-water emulsion lotion containing a sulfated polysaccharide or a salt thereof.

[0085]

According to the present invention, the emulsion stability is improved by blending an emulsion stabilizer such as reduced lanolin with an oil-in-water emulsion lotion containing a sulfated polysaccharide or a salt thereof. In addition, it is possible to provide an oil-in-water emulsion lotion having a skin moisturizing effect equivalent to that of an emulsion ointment (cream).

[Brief description of the drawings]

FIG. 1 is a view showing the results of a moisturizing effect test I.

FIG. 2 is a diagram showing the results of a moisturizing effect test II.

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Takaaki Doi 2045-1-101 Yasakacho, Hikone City, Shiga Prefecture

Claims (6)

[Claims] 1. An oil-in-water emulsion lotion containing a sulfated polysaccharide and / or a salt thereof and an emulsion stabilizer. 2. The oil-in-water emulsion lotion according to claim 1, wherein the emulsion stabilizer is reduced lanolin. 3. The oil-in-water emulsion lotion according to claim 1, wherein the sulfated polysaccharide is a polysulfate of mucopolysaccharide. 4. The oil-in-water emulsion lotion according to claim 1, wherein the sulfated polysaccharide is a heparin-like substance. 5. The oil-in-water emulsion lotion according to claim 1, wherein the sulfated polysaccharide is a polysulfate of chondroitin sulfate. 6. An oil-in-water emulsion lotion containing a heparin-like substance, reduced lanolin and a carboxyvinyl polymer.