JPH1067625A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for oral cavity capable of stably keeping an activity of a lipophilic component in a formulation and having excellent use feeling by performing a specific treatment to the lipophilic component. SOLUTION: This composition is composed of gellan gum as a lipophilic component as a principal component, preferably a lipophilic component-buried gellan gum capsule buried with a covering film formed in the presence of preferably bifunctional cation is mixed into the composition. As the lipophilic component, a flavor component, an oil-soluble vitamin, a nonionic bactericide or a lipophilic pigment, etc., is exemplified. The gellan gum is a mucilage produced by a microorganism. In forming the covering film, strength and stability of the covering film can be further increased by allowing a bifunctional cation (preferably Ca ion and Mg ion) to coexist. In a composition for oral cavity, a mixing ratio of the lipophilic component-buried gellan gum capsule is about 0.1-10wt.% of whole of the composition. As the composition for oral cavity, dentifrices such as toothpaste or tooth wash, gingiva massage cream, etc., is exemplified.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral composition containing a lipophilic component. More specifically, the present invention can stably maintain the activity of a lipophilic component in a preparation and has a good feeling in use. It relates to an oral composition.

[0002]

2. Description of the Related Art
An oral composition such as a dentifrice contains a lipophilic component such as a flavoring agent to enhance palatability, a medicinal component such as vitamin E, and a fungicide such as triclosan and isopropylmethylphenol. However, these lipophilic components are easily adsorbed or taken up by the abrasives, surfactants, container surfaces, and the like in the dentifrice, so that the effect is reduced, and there is a problem that the sufficient effect is not exhibited.

[0003] On the other hand, a thickness of 0.03 mm to 0.6 mm based on an edible polymer compound such as gelatin or pullulan.
0.5 mm to 1 mm in diameter with oil and fat products contained in a coating of about
Capsules having a shape of about 0 cm have been used in the fields of not only pharmaceuticals but also health foods, general processed goods, cosmetics and the like. The above-mentioned capsules can accurately and individually package a single use amount and intake amount of an oily substance, and are edible, safe, highly stable, and have performance as a sealed container. At present, it is considered to be the only technology for processing oil and fat foods having these functions.

[0004] Therefore, as a means for stably blending the lipophilic component into an oral composition such as a dentifrice, a method utilizing the above-mentioned capsule is considered.

[0005] However, due to the limitation that the capsule is water-soluble, the capsule swells and dissolves over time even at room temperature when the capsule is blended with an oral composition such as a dentifrice to release the contents. Even if the coating is thickened, the surfactants incorporated into the oral composition such as dentifrices will surely cause the disintegration and deterioration of the coating, and it is difficult to maintain long-term stability.

Further, when the surface of the capsule is coated with a water-insoluble component such as wax or ethyl cellulose,
Although the stability at the time of blending is improved, the capsules are hard and have poor disintegration properties. Therefore, there has been a problem that the oral composition containing the blend has a foreign-body sensation during use and is inferior in use sensation.

[0007] Further, oral compositions having various functions given by blending granules or capsules with the oral composition have been proposed. For example, a pigment is blended with granules, and the pigment is revealed during brushing for the purpose of an indicator at the end of dentifrice (described in JP-A-60-16913). Granular taste components and granules coated with a coating substance A toothpaste base is mixed to change the taste during toothbrushing (described in JP-A-62-116505), and a granule is blended with a medicinal ingredient to stabilize the drug (JP-A-6-116505). 48-1
Nos. 9738, 49-132249, 55-153
No. 709, JP-A-3-271215) and those for removing plaque (JP-A-1-299211, 4-243816) have been proposed.

However, it is difficult to embed the lipophilic component in the above-mentioned granules and capsules. The coating becomes brittle due to the agent, the fragrance component, etc., and the lipophilic component is quickly released, and there is a problem in use such as a feeling of foreign matter.

[0009] Therefore, there has been a demand for the development of a technique for blending an lipophilic component with an oral composition while maintaining its activity stably, and also maintaining a good feeling in use.

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a lipophilic component-containing oral composition that can stably maintain the activity of a lipophilic component and is excellent in use feeling. .

[0011]

Means for Solving the Problems and Embodiments The present inventors have conducted intensive studies in order to achieve the above-mentioned object. As a result, the present inventors have found that the lipophilic component contains gellan gum as a main component, preferably in the presence of a divalent cation. When the lipophilic component-embedded gellan gum capsule embedded with the film formed by the coating is mixed with the oral composition, the activity of the lipophilic component is stably maintained, and the oral composition excellent in the feeling of use is obtained. And found that the present invention was achieved.

[0012] Accordingly, the present invention provides an oral composition characterized by comprising a gellan gum capsule in which a lipophilic component is embedded in gellan gum.

Hereinafter, the present invention will be described in more detail. Examples of the oral composition of the present invention include toothpastes, liquid dentifrices, dentifrices such as liquid dentifrice, gingival massage creams, and paste-like topical application agents. In particular, it is used in a paste state, and contains a lipophilic component-embedded gellan gum capsule in which a lipophilic component is embedded in a coating containing gellan gum as a main component. Gellan gum is a mucous polysaccharide produced by microorganisms.

In the above oral composition, the lipophilic component to be blended is not particularly limited, and lipophilic components usually blended can be used. For example, fragrance components, oil-soluble vitamins, nonionic fungicides, Oily dyes and the like. Specifically, fragrance components include menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineole, linalool, ethyl linalool, wanilin, thymol, spearmint oil, peppermint oil, Lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, laurel oil, perilla oil, winter green oil,
T-shaped oil, eucalyptus oil and the like are exemplified.

[0015] Specific examples of the oil-soluble vitamins and nonionic fungicides include vitamin E, vitamin D, vitamin A, lecithin, β-carotene, DHA (docosahexaenoic acid), EPA (eicosapentaenoic acid), liver oil, and squalene. And medium chain fatty acid triglycerides, food oils, lipophilic fungicides such as triclosan, isopropylmethylphenol, bisabolol and the like. These lipophilic components may be used alone or in combination of two or more.

Further, specific examples of the lipophilic dye include Red 215, Red 225, Red 226, and Yellow 2
No. 04, Yellow No. 205, Green No. 202, Purple No. 201,
Copper chlorophyll, β-carotene, etc. can be embedded singly or in combination of two or more. By mixing these pigments and coloring components, visibility can be improved, an indicator effect can be given, and appearance can be adjusted. It is.

In the present invention, the lipophilic component is embedded in a coating containing gellan gum as a main component. In forming such a coating, gellan gum is made to coexist with a divalent cation. In addition, the strength and stability of the coating can be further improved. The type of the cation is not particularly limited, and a cation that can be supplied at the time of forming such a film can coexist. In the case of the present invention, among the divalent cations, calcium ion and magnesium ion are particularly preferable. desirable. The salt for supplying such a divalent cation is not particularly limited as long as it is a water-soluble salt. For example, calcium lactate, magnesium sulfate, calcium chloride, magnesium chloride,
Calcium gluconate is preferably used.

When the above salts are used, the mixing ratio with respect to gellan gum can be appropriately selected. The mixing ratio is expressed by weight ratio of gellan gum: salt = 1: 0.1 to 0.1%.
The ratio is desirably 1: 4, particularly 1: 0.2 to 1: 3. If the compounding ratio of the salts is too low, the effect of compounding the salt may not be sufficiently obtained.If the compounding ratio is too high, not only no further improvement in the coating strength can be obtained, but also In some cases, astringency is developed to reduce the feeling of use.

As an alternative to the salts for supplying divalent cations, it is possible to use salts for supplying monovalent cations. Examples of such salts include sodium chloride, potassium chloride and citric acid. Trisodium, sodium acetate and the like can also be used. In this case, the mixing ratio is gellan gum: salts = 1: 1 to 1: 2 by weight ratio.
0, especially 1: 1 to 1:10.

In addition, a hydrophilic polymer or a lipophilic polymer can be added to the above-mentioned film together with gellan gum for the purpose of improving the feeling of use as long as the effects of the present invention are not impaired. In this case, as the hydrophilic polymer substance, gelatin, sodium alginate, carrageenan,
Agar, carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, gum arabic, guar gum, xanthan gum, casein, pectin, albumin, polyvinyl alcohol and the like are exemplified. In addition, as the lipophilic polymer substance, polyacrylic acid, polymethacrylic acid, stearyl alcohol, microcrystalline wax, beeswax,
Carnauba wax and the like are exemplified. These polymer substances may be used alone or in combination of two or more.

In the present invention, as a method for embedding the lipophilic component in a film containing gellan gum as a main component, for example, a dropping method (Japanese Patent Publication Nos. 51-8875 and 53-106).
No. 7, see Japanese Patent Application Laid-Open No. 4-45753), but the method is not limited as long as a similar gellan gum capsule can be produced.

The particle size of the gellan gum capsule embedded with the lipophilic component has an average particle size of 0.3 to 4 mm, especially 0.1 to 4 mm.
It is desirable to be in the range of 5 to 3 mm. If the average particle size is too small, problems such as a decrease in particle strength, a decrease in the amount of the lipophilic component, and an increase in air oxidation due to an increase in the surface area of the coating may occur. There is a problem in that when the composition is blended with the composition, a foreign-body sensation is produced or oiliness is felt.

Further, the coating strength of the gellan gum capsule embedded with a lipophilic component can be measured, for example, by using SUN R manufactured by Sun Kagaku Co., Ltd.
When measured using a HEO METER Model CR-200D, when one of the particles is placed at an interval between two hard surfaces in a state of infiltration in water and compressed at a load speed of 3 mm / min, the collapse load is A range which disintegrates in the range of 0.3 to 30 g / piece, particularly 1 to 20 g / piece and releases the contents is preferable. Particles with too small collapse load
The lipophilic component may be easily eluted in the composition, or the particles may be broken during the production of the composition. If the disintegration load is too large, if the disintegration load exceeds 30 g / unit, it is added to the oral composition. In some cases, a feeling of a foreign substance is felt when the brush is brushed, and the brush does not decompose at all, resulting in poor use feeling.

In the composition of the present invention, the mixing ratio of the gellan gum capsule embedded with the lipophilic component is 0.1 to 10% (% by weight, hereinafter the same) of the whole composition, especially 0.5 to 1%.
The content is desirably 0%. If the blending ratio is too low, the effect of the embedded lipophilic component may not be sufficiently exhibited, and if it is too high, a good feeling in use may not be obtained.

In the oral composition of the present invention, in addition to the above-mentioned components, appropriate components according to the purpose, the kind of the composition and the like can be further compounded at a usual dose.

For example, in the case of dentifrices, dibasic calcium phosphate dihydrate and anhydride, monobasic calcium phosphate,
Tertiary calcium phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina, silicic acid, aluminum silicate, insoluble sodium metaphosphate, tertiary magnesium phosphate, magnesium carbonate, calcium sulfate, polymethyl methacrylate, bentonite,
One or two of zirconium silicate and other synthetic resins
More than one species can be blended (usually 5 to 60%).

In the case of paste-form compositions such as toothpaste, cellulose derivatives such as carrageenan, sodium carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, sodium carboxymethylhydroxyethylcellulose, xanthan gum, tragacanth gum, karaya gum, and arabic are used as binders. One or two of gums such as gums, synthetic binders such as polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, and polyvinylpyrrolidone, and inorganic binders such as silica gel, aluminum silica gel, veegum, and laponite.
More than one kind can be blended (normally blended amount 0.2-5%).

Further, paste or liquid oral compositions such as dentifrices include sorbitol, glycerin,
Ethylene glycol, propylene glycol, 1,3-
One or more of butylene glycol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, lactitol and the like may be blended (normal blending amount: 10 to 80%).

If necessary, the composition of the present invention may contain menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineol, linalool without being embedded in a gellan gum capsule. Ethyl linalool, crocodile, thymol, spearmint oil,
Peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon oil, perilla oil,
Flavors such as winter green oil, t-shaped oil, eucalyptus oil and the like can be blended alone or in combination of two or more.
%) In addition, sweeteners such as saccharin sodium, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perillartin, thaumatin, asparatyl phenylalanine methyl ester, p-methoxycinnamic aldehyde, and the like can be blended (normal blending amount: 0.01 to 0.01%).
1%).

In the present invention, enzymes such as dextranase, mutanase, lysozyme, amylase, protease, lytic enzyme, superoxide demutase, and sodium monofluorophosphate are used as active ingredients within a range not to impair the effects of the present invention. , Alkali metal monofluorophosphates such as potassium monofluorophosphate, sodium fluoride, fluorides such as stannous fluoride, tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxyallantoin, dihydrocholestanol, glycyrrhizic acids, glycyrrhetinic acids , Bisabolol, isopropylmethylphenol, glycerophosphate, chlorophyll, copper gluconate, sodium chloride, water-soluble inorganic phosphate compound, triclosan, cetylpyridinium chloride , Benzalkonium chloride, may be incorporated one or more kinds of active ingredients, such as benzethonium chloride. In addition, the compounding amount of the active ingredient can be a usual amount as long as the effect of the present invention is not hindered.

Further, as the surfactant, an anionic surfactant, a nonionic surfactant and an amphoteric surfactant can be used. Examples of the anionic surfactant include sodium alkyl sulfate such as sodium lauryl sulfate and sodium myristyl sulfate, sodium N-acyl sarcosinate such as sodium N-lauroyl sarcosinate, sodium N-myristoyl sarcosinate, sodium dodecylbenzene sulfonate, hydrogen N-acylglutamic acid salts such as sodium coconut fatty acid monoglyceride monosulfate monosodium sulfate, sodium lauryl sulfoacetate, sodium N-palmitoyl glutamate, sodium N-methyl-N-acyltaurine, sodium N-methyl-N-acylalanine, α-olefin sulfone For example, sodium acid is used.

Examples of the nonionic surfactant include sugar fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester and lactose fatty acid ester, sugar alcohol fatty acid esters such as maltitol fatty acid ester and lactitol fatty acid ester, and polyoxyethylene sorbitan monolaurate. Polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monostearate, polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, lauric acid mono- or diethanolamide, fatty acid diethanolamides such as myristic acid mono- or diethanolamide, Sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene poly Such as oxypropylene fatty esters are used.

Examples of the amphoteric surfactant include N-alkyldiaminoethylglycine such as N-lauroyldiaminoethylglycine and N-myristyldiaminoethylglycine, N-alkyl-N-carboxymethylammonium betaine, and 2-alkyl-1-alkyl. Hydroxyethylimidazoline betaine sodium is used.

In this case, as the surfactant, anionic surfactants and nonionic surfactants are preferably used, and more preferably, sodium alkyl sulfate such as sodium lauryl sulfate and polyoxyethylene polyoxypropylene copolymer are used. Can be

These surfactants may be used alone or in combination of two or more. Also,
The amount of the surfactant is usually 0.5 to 20 of the whole composition.
%, Particularly preferably 1 to 20%.

The composition of the present invention can be blended with dyes and coloring agents and dyed. In this case, various pigments and coloring agents are used.
No., Red No. 225, Red No. 226, Yellow No. 4, Yellow No. 5
No., Yellow No. 205, Blue No. 1, Blue No. 2, Blue 201
No. 4, Blue No. 204, Green No. 3, titanium mica, titanium oxide and the like are preferably used. In addition, among the above components, the oil-soluble component can be used by embedding it in gellan gum, but a part thereof may be blended without being embedded.

[0037]

The oral composition of the present invention can stably maintain the activity of the compounded lipophilic component, and is excellent in the feeling of use without the feeling of foreign matter, oiliness and stickiness. It can be prepared into various dosage forms and used widely.

[0038]

EXAMPLES The present invention will now be described specifically with reference to experimental examples and examples, but the present invention is not limited to the following examples. In addition, all% in each example are weight%.

[Manufacture example 1 of gellan gum capsule] Gellan gum capsule A containing menthol according to the following formulation example
500 g (average particle diameter 1 mm, collapse load 10 g / piece) was produced by a dropping method (Japanese Patent Application Laid-Open No. 1-193216, the method of Example 5 and the same hereinafter). For comparison, a gellan gum capsule A ′ having an average particle size of 0.2 mm and a collapse load of 10 g / piece was similarly produced. Capsule liquid: menthol, medium-chain fatty acid triglyceride, green No. 202 Capsule coating: gellan gum, calcium lactate, water Gellan gum capsule production example 2 Gellan gum capsule B containing vitamin E according to the following formulation example (average particle size 2)
(mm, collapse load 20 g / piece) 1 kg was produced by a dropping method. For comparison, a gellan gum capsule B ′ having an average particle size of 5 mm and a collapse load of 20 g / piece was similarly produced. Capsule liquid: Vitamin E, squalene Capsule coating: Gellan gum, calcium lactate, water Gellan gum capsule production example 3 Gellan gum capsule C containing isopropylmethylphenol according to the following formulation example (average particle size 1.5 mm, disintegration load 5 g / piece) ) 50
0 g was produced by a dropping method. For comparison, a gellan gum capsule C ′ having an average particle size of 1.5 mm and a collapse load of 0.2 g / piece was similarly produced. Capsule content liquid: isopropylmethylphenol, medium-chain fatty acid triglyceride Capsule coating: gellan gum, calcium lactate, water Gellan gum capsule production example 4 Gellan gum capsule D containing lemon oil according to the following formulation example (average particle size 1 m)
m, collapse load 15 g / piece) 300 g was produced by a dropping method. For comparison, a gellan gum capsule D ′ having an average particle size of 1 mm and a collapse load of 45 g / piece was similarly produced. Capsule liquid: lemon oil, medium-chain fatty acid triglyceride, copper chlorophyll Capsule coating: gellan gum, calcium lactate, water

[Experimental Examples 1 and 2] Gellan gum capsule A or A ′ prepared in Production Example 1 2% Silica anhydride 14 Propylene glycol 3 Sorbite solution (60%) 22 Carboxymethylcellulose 1.5 Saccharin sodium 0.1 Sodium lauryl sulfate 1.0 Perfume 1.0 Water Balance meter 100.0%

[Experimental Examples 3 and 4] Gellan gum capsule B or B 'prepared in Production Example 2 1% aluminum hydroxide 30 propylene glycol 3 glycerin (85%) 21 carboxymethylcellulose 1 tranexamic acid 0.01 sodium saccharin 0.1 lauryl Sodium sulfate 2.0 Fragrance 1.1 Water Balance meter 100.0%

[Experimental Examples 5 and 6] Gellan gum capsule C or C ′ prepared in Production Example 3 0.5% dibasic calcium phosphate dihydrate 40 glycerin (85%) 20 xanthan gum 0.5 sodium polyacrylate 0 .7 Saccharin sodium 0.1 Sodium lauryl sulfate 1.5 Fragrance 1.5 Water Balance meter 100.0%

[Experimental Examples 7 and 8] Gellan gum capsule D or D 'prepared in Production Example 4 1.5% Silicic anhydride 16 Glycerin (85%) 20 Sorbite solution (60%) 47 Polyethylene glycol 5 Xanthan gum 0.2 Sodium polyacrylate 0.7 Sodium saccharin 0.2 Sodium lauryl sulfate 2.0 Fragrance 1.2 Water Balance meter 100.0%

Preparation of the Oral Composition (Experimental Examples 1 to 8)
Then, under each temperature condition (25 ℃, 40 ℃, 50 ℃)
Stored in a laminated tube,
Stability (1-3 months) and usability are evaluated according to the following criteria
Valued. Table 1 shows the results. Particle appearance ：: equivalent to that at the time of blending, no change △: particles swelling ×: particle coating partially brokenFeeling of use ：: Good feeling of use △: Slight foreign matter feeling, slightly oily, slightly sticky
R ×: Foreign substance feeling, oily, sticky feelingLeachability of lipophilic components Collect 50 gellan gum capsules from oral composition
And add 3 ml of methanol and use a glass homogenizer.
The particle coating was pulverized, and the contents were sufficiently dispersed. to this
Add 3 ml of the internal standard as shown below and add exactly 1
0 ml and measured under the following conditions.
The dissolution was evaluated. Table 1 shows the results. Measurement condition : Examples 1 and 2: Using menthol as an index under the following conditions
It was measured. Internal standard solution: Methanol solution of benzyl propionate
(2.5 → 100) Detector: Flame ionization detector Column: A glass tube with an inner diameter of about 2 mm and a length of about 2 m
Acid treatment of ethylene glycol (PEG 20M) and
150-180 μm gas treated with dimethylchlorosilane
Diatomaceous earth for chromatography is coated at a rate of 10%.
of. Column temperature: constant temperature around 130 ° C Injection part temperature: constant temperature around 240 ° C Carrier gas: nitrogen Flow rate: menthol elution time to about 11 to 13 minutes
Adjust so that Experimental Examples 3 and 4: Using vitamin E as an index, under the following conditions
It was measured. Internal standard solution: Ergocalciferol in methanol
(1 → 80000) Detector: UV absorption spectrophotometer (measuring wavelength: 284 nm) Column: Stainless steel with inner diameter of about 4 mm and length of about 15 cm
Approximately 5μm octadecyl silicide for liquid chromatography
Fill with lylated silica gel. Column temperature: room temperature Mobile phase: methanol Flow rate: Vitamin E retention time was about 10 minutes
Adjust so that Experimental Examples 5 and 6: Use isopropylmethylphenol as an index
And measured under the following conditions. Internal standard solution: Isoamyl paraoxybenzoate in methanol
Solution (1 → 125000) Detector: UV absorption spectrophotometer (measuring wavelength: 280 nm) Column: Stainless steel with inner diameter of about 4 mm and length of about 15 cm
Approximately 5μm octadecyl silicide for liquid chromatography
Fill with lylated silica gel. Column temperature: constant temperature around 45 ° C. Mobile phase: water: acetonitrile: glacial acetic acid mixture (60:
40: 1) Flow rate: Retention time of isopropylmethylphenol
Adjust to about 16 minutes. Experimental Examples 7 and 8: Measured under the following conditions using limonene as an index.
Specified. Internal standard solution: Methanol solution of benzyl propionate
(2.5 → 100) Detector: Flame ionization detector Column: A glass tube with an inner diameter of about 2 mm and a length of about 2 m
Acid treatment of ethylene glycol (PEG 20M) and
150-180 μm gas treated with dimethylchlorosilane
Diatomaceous earth for chromatography is coated at a rate of 10%.
of. Column temperature: constant temperature around 130 ° C. Injection part temperature: constant temperature around 240 ° C. Carrier gas: nitrogen Flow rate: limonene elution time was about 11 to 13 minutes
Adjust so that Elution rate (%) = [1- (parent remaining in 50 capsules)
Amount of oily component / lipophilicity in 50 capsules formulated in the formulation
Component amount)] x 100

[0045]

[Table 1]

Example 1 Gellan gum capsule prepared in Production Example 1 4% Glycerin (85%) 12.0 Ethanol 6.0 Polyoxyethylene (60 mol) hydrogenated castor oil 0.2 Sucrose monopalmitate 3 Saccharin sodium 0.1 Fragrance 0.7 Water Balance meter 100.0%

[Example 2] Vitamin A-containing gellan gum capsule 2% (particle size 2mm, disintegration load 3g / piece, divalent salt in the film: calcium lactate) Propylene glycol 5 Glycerin (85%) 20 Sorbit (60%) 40 Silicic anhydride 20 Sodium polyacrylate 0.8 Xanthan gum 0.3 Blue No. 1 (0.1%) 0.3 Sodium saccharin 0.1 Sodium lauryl sulfate 1.8 Fragrance 1.5 Water Balance meter 100.0%

Example 3 β-carotene-containing gellan gum capsule 1% (particle size 1 mm, disintegration load 1 g / piece, divalent salt in coating: magnesium sulfate) Propylene glycol 3 Tranexamic acid 0.1 Sorbit (60%) 20 Dibasic calcium phosphate dihydrate 40 Sodium carboxymethyl cellulose 1.5 Saccharin sodium 0.12 Sodium lauryl sulfate 1.3 Fragrance 1.1 Water Balance meter 100.0%

Example 4 Gellan Gum Capsule Containing Triclosan 0.5% (particle size 3 mm, collapse load 5 g / piece, divalent salt in coating: calcium chloride) Propylene glycol 3 dipotassium glycyrrhizinate 0.05 glycerin (85%) 20 Silicic anhydride 15 Sodium carboxymethylcellulose 1.0 Carrageenan 0.2 Sodium saccharin 0.1 Sodium lauryl sulfate 1.6 Fragrance 1.0 Water Balance meter 100.0%

Example 5 Gellan gum capsule containing peppermint oil 2.5% (particle size 0.8 mm, collapse load 4 g / piece, divalent salt in coating: magnesium chloride) Propylene glycol 5 sorbit (60%) 22 Hydroxide Aluminum 40 Carrageenan 1 Saccharin sodium 0.1 Sodium lauryl sulfate 1.8 Fragrance 0.8 Water Balance meter 100.0%

Claims (2)

[Claims] 1. A composition for oral cavity comprising a gellan gum capsule in which a lipophilic component is embedded with a coating containing gellan gum as a main component. 2. The oral composition according to claim 1, wherein the coating is formed in the presence of a divalent cation.