JPH1029911A - Cosmetic material composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition which is useful as a cosmetic material having efficacy for prevention and improvement of the abnormality of skin such as somber and stained skins, skin-roughening pimples, face melasma and chloasma caused by peroxidezed lipids by formulating a specific component thereto. SOLUTION: This objective cosmetic material composition contains an extract of soybean (soybean saponin is contained in an content of more than 85%) and adzuki bean powder (adzuki bean saponin is contained in a content of more than 80%) as essential components. As the components in the whole composition, the extract of soybean and the adzuki bean powder are preferably formulated in an amount of 0.01-0.05wt.%, respectively. The soybean saponin formulated in the composition is obtained by extracting it from soybeans and then purifying it with a solvent or by selectively adsorbing the saponin with a resin adsorbent from the extract and then purifying it. Further, the adzuki bean saponin is obtained by removing fat from seeds of adzuki bean, concentrating the extracted solution, distributing it with water and n-butanol and purifying it.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic composition, and its object is to prevent skin abnormalities caused by lipid peroxide, that is, to prevent and improve the occurrence of dullness, spots, and rough skin. It is to provide a composition.

In recent years, with the spread of awareness of gender equality, social life has also changed, and women are increasingly entering the workplace, and women are often stressed by work and personal relationships. Changes naturally affect the skin of women, and the skin is easily damaged, causing dullness, spots, and rough skin. According to the Cosmetic Report of the Japan Cosmetic Industry Association, 80% of Japanese women felt "dull skin and rough skin" in a survey of Japanese women's awareness of "dull skin and rough skin". It can be said that the effect of the change in the living environment described above is how great it is for modern Japanese women. More recently, the diet of western diet has become more prevalent among young women in particular, resulting in excessive fat intake and increased lipid peroxide in the body.
It has been regarded as a problem that many skin abnormalities such as rough skin, melanosis of the face, and hepatic plaque occur to accelerate aging of the skin.

[0003] Under such circumstances, the role of cosmetics is great, and there is a problem not only in keeping the skin warm and preventing drying out, but also how to actively prevent and remove dullness, spots, and rough skin. Have been.

[0004]

2. Description of the Related Art Various attempts have been made with various plant components to prevent aging of the skin and enhance the beautiful skin effect.
However, in order to improve skin abnormalities due to lipid peroxide, that is, dullness and spots of the skin, rough skin, acne, melasma acne, melasma, etc., the effect has not yet been expected.

[0005]

Means for Solving the Problems The applicant of the present invention can take the saponin component extracted from soybean seeds orally,
They have found that they suppress lipid peroxide in the body, and have also found that azoxaponin extracted from red bean seeds has a similar effect. (Japanese Patent Publication No. 55-66284 and Japanese Patent Publication No. 62-17598)

The present invention is intended to provide a cosmetic composition which can be suitably used to solve the problem of preventing and removing skin abnormalities caused by lipid peroxides. During the intensive research, the soybean saponin and azoxaponin were combined, and a cosmetic composition formulated in a specific amount was appropriately used on the skin, so that skin abnormalities due to lipid peroxide, such as dullness and spots on the skin, acne on rough skin, The present inventors have found that the present invention exhibits excellent effects in preventing and improving melanosis of the face and melasma, etc., and have reached the present invention.

[0007]

The soybean saponin used as an active ingredient of the cosmetic composition of the present invention is extracted and separated from soybean and purified with a solvent, or selectively adsorbs saponin from the extract using a resin adsorbent. And purified. For example, after soybean powder as a raw material is defatted using a normal fat-soluble organic solvent, the active ingredient is extracted using water or a lower aliphatic alcohol or a hydrated lower aliphatic alcohol, and the extract is concentrated by evaporation. Extract.
This is dissolved in water-saturated n-butanol, water is added to the solution, and the mixture is shaken and allowed to stand. The n-butanol layer is separated and evaporated to dryness. Alternatively, the extracted extract is dissolved in a mixed suspension of n-butanol and water (1: 1), and allowed to stand for n
-The butanol layer may be separated and evaporated to dryness. After dissolving the obtained evaporation residue in lower fatty acid alcohol, the mixture is poured into ether with stirring, and the resulting precipitate is filtered to obtain a target soybean saponin. The obtained soybean saponin usually has slightly bitter yellowish-brown color and has the following properties. (1) Easily soluble in methanol and dilute ethanol, soluble in water and ethanol, poorly soluble in chloroform, ether, hexane and carbon tetrachloride. (2) 1% aqueous solution is neutral. (3) Infrared absorption 1R: ν _max (nujol) 3400 (br) 3350 (br), 1720 (br) and 1710 (b)
r) ^-1 _cm (4) Thin layer chromatography Carrier: Kieselgel 60F254 (Merck) plate Developing solvent: chloroform-methanol-water (6: 4:
1) Spray 1% sulfuric acid second selenium-10% sulfuric acid mixture,
When heated, it shows a distinct red-purple saponin spot. (5) Glucuronic acid from the water-soluble part by acid hydrolysis,
Galactose, glucose, arabinose, rhamnose and xylose are obtained. From the water-insoluble part, soyasapogenol A (C ₃₀ H ₅₀ O ₄ , melting point 310 to 312 ° C.) as a main constituent genin body, and soyasapogenol B (C ₃₀ H
₅₀ O ₃ , melting point 260-261 ° C.), and other trace amounts of soyasapogenols C, D and E are observed. (6) Liebermann reaction and Zalkowski reaction positive. (7) When added to water and shaken, persistent small bubbles are generated. In the cosmetic composition of the present invention, 85% or more of the above-mentioned soybean saponin is dissolved or dispersed in a solvent such as alcohol to be blended as an active ingredient (soybean extract). The blending amount can be appropriately selected according to the desired dosage form, but is usually from 0.001 to 2% by weight of soybean saponin, preferably from 0.01 to 0.05% by weight, based on the total amount of the composition. It is preferable in terms of effect.

Azoxaponin as an active ingredient of the cosmetic composition of the present invention is a substantially pure saponin.
The term “substantially pure” as used herein means that it contains at least 90% or more, preferably 98% or more of saponins alone. To produce this substantially pure saponin material, red bean seeds are defatted, then extracted with lower aliphatic alcohols or their hydrates, the extract is concentrated, and the concentrated extract is combined with water and n-butanol. And concentrating the butanol layer, and purifying the resulting crude saponins to isolate azoxaponins. Hereinafter, details of the production method will be specifically described.

The adzuki seed as a raw material is pulverized by removing the seed coat as much as possible. This pulverized material is degreased. At that time, a normal fat-soluble organic solvent, for example, ether, benzene, petroleum ether, ligroin, ethyl acetate and the like are used,
Preferred is ethyl acetate. This defatted product is subjected to an extraction treatment with a lower aliphatic alcohol or a hydrate thereof. This extraction is carried out by heating the solvent used to the extent that it is boiled. Examples of lower aliphatic alcohols include netanol, ethanol, propanol, butanol, etc., with methanol being most preferred. This extraction treatment is preferably repeated several times, and the amount of solvent used at one time is 2 to 4 times based on the degreased product.
It is preferably about twice (weight / weight). Subsequently, the extract is concentrated at a low temperature and a low pressure as much as possible. Since a brown precipitate is formed when the concentration is performed to some extent, it is desirable to filter this. The filtrate is further concentrated to an extract. This concentrate (extract) is partitioned between water and n-butanol. This partitioning process involves (i) shaking the concentrate with a mixture of water and n-butanol in a weight ratio of about 2: 1 to about 1: 2, preferably about 1: 1 (ii) ) Suspending the concentrate in water and shaking with n-butanol or (ii)
i) After dissolving the concentrate in water-saturated n-butanol, water may be added and the mixture may be shaken. The target saponin component is transferred to the n-butanol layer at room temperature, and concentrated at low temperature and low pressure until it dries. This concentrate consists of crude saponins, but if this is dissolved in a soluble organic solvent and added to an insoluble solvent or an insoluble solvent is added, the saponins are purified and precipitated. I do.
The azoxaponins thus obtained contain substantially only the saponin component and can be used as such as the active ingredient of the present invention.

The adzuki powder in the cosmetic composition of the present invention contains at least 80% of substantially pure azoxaponin, and the amount thereof can be appropriately selected according to the desired dosage form. Therefore, the content of soybean saponin is preferably 0.001 to 2% by weight, more preferably 0.01 to 0.05% by weight.

[0011]

EXAMPLES Hereinafter, practical examples in which the cosmetic composition of the present invention is a face wash and a lotion will be described, but these are merely examples, and the present invention is not limited thereto.

(Example 1. Face wash) Soybean extract (soybean saponin 85%) 0.02% by weight Azuki powder (azoxaponin 80%) 0.02 Lauric acid 5.00 Oleic acid 8.00 1,3-butylene glycol 18.00 Sorbit solution 45.00 Phenoxyethanol 0.20 Purified water 23.76

Example 2. Cosmetics Soybean extract (85% soybean saponin) 0.02 Azuki powder (80% azusaponin) 0.02 Paraoxybenzoate 0.30 Ethyl alcohol 10.00 (% by weight) Propylene Glycol 5.00 allantoin 0.05 3-butylene glycol 5.00 water-soluble collagen solution 0.20 sodium hyaluronate solution 0.02 yeast extract 0.50 purified water 78.89

(Effects of Use of Facial Cleanser of Example 1) Ten women (in total, 20 women) who have daily intake of a large amount of fatty food and have skin spots, dark spots, and rough skin, and among these women, Ten face washers were selected to use this face wash twice a day in the morning and before going to bed, and one month later the effect was investigated. Table 1 shows the survey results. The evaluation criteria were divided into the following five stages according to the degree of symptoms, and the degree of improvement was determined based on the degree of increase in the evaluation stage before and after use, and is shown in Table 2.

(Evaluation Criteria) Stain 5. The face is clearly stained and its color is dark. 4. You can see clear spots on the face, but they are not noticeable if you apply makeup. 3. There is a spot on the face, but the outline is not so clear. 2. I have spots on my face but I don't know unless I look closely. 1. I can hardly see the face stains.

[0016] dullness 5. It is dark and dark and spreads all over the skin and face. 4. The skin and face are firm and dark, with dark spots. 3. I am worried that there is dullness around my face, especially around my eyes. 2. There are dullness around my eyes and around my face, but I can't tell unless I look closely. 1. There is almost no dullness on the skin or face.

Rough skin 5. The skin looks dull and the makeup is not applied. 4. The skin is not shiny and the makeup is not very good. 3. The gloss of the skin is not particularly good or bad. 2. Skin color and make-up are getting better. 1. The skin is irritated, the face becomes brighter, and the makeup spreads well.

[0018]

As described above in detail, the cosmetic composition containing soybean saponin and azoxaponin as essential components according to the present invention promotes the activity of the skin, and improves the dullness, spots, and roughness of the skin due to lipid peroxide. Has a remarkable effect.

[Table 1]

[Table 2]

Claims (4)

[Claims] 1. A cosmetic composition comprising soy extract and adzuki bean powder as essential ingredients. 2. The soy extract contains 85% soybean saponin.
2. The cosmetic composition according to claim 1, wherein the adzuki powder contains 80% or more of azoxaponin. 3. The cosmetic composition according to claim 1, wherein the soybean extract and the adzuki bean powder are each incorporated in an amount of 0.001 to 2% by weight. 4. The cosmetic composition according to claim 1, wherein the soybean extract and the adzuki bean powder are each incorporated in an amount of 0.01 to 0.05% by weight.