JPH10204082A5 - - Google Patents

Info

Publication number
JPH10204082A5
JPH10204082A5 JP1997325116A JP32511697A JPH10204082A5 JP H10204082 A5 JPH10204082 A5 JP H10204082A5 JP 1997325116 A JP1997325116 A JP 1997325116A JP 32511697 A JP32511697 A JP 32511697A JP H10204082 A5 JPH10204082 A5 JP H10204082A5
Authority
JP
Japan
Prior art keywords
thiophene
benzo
alkyl
piperidin
benzoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP1997325116A
Other languages
English (en)
Japanese (ja)
Other versions
JPH10204082A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JPH10204082A publication Critical patent/JPH10204082A/ja
Publication of JPH10204082A5 publication Critical patent/JPH10204082A5/ja
Withdrawn legal-status Critical Current

Links

JP9325116A 1996-10-25 1997-10-20 選択的エストロゲンレセプターモジュレーターとしての活性を有する置換されたベンゾ［ｂ］チオフェン化合物 Withdrawn JPH10204082A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2905696P 1996-10-25 1996-10-25
US60/029056 1996-10-25

Publications (2)

Publication Number Publication Date
JPH10204082A JPH10204082A (ja) 1998-08-04
JPH10204082A5 true JPH10204082A5 (enExample) 2005-06-30

Family

ID=21846972

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9325116A Withdrawn JPH10204082A (ja) 1996-10-25 1997-10-20 選択的エストロゲンレセプターモジュレーターとしての活性を有する置換されたベンゾ［ｂ］チオフェン化合物

Country Status (7)

Country Link
US (1) US5962475A (enExample)
EP (1) EP0838464B1 (enExample)
JP (1) JPH10204082A (enExample)
AT (1) ATE249454T1 (enExample)
CA (1) CA2218756A1 (enExample)
DE (1) DE69724733T2 (enExample)
ES (1) ES2206664T3 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69634045T2 (de) 1995-10-31 2005-05-19 Eli Lilly And Co., Indianapolis Antithrombotische diamine
WO2001026651A2 (en) * 1999-10-14 2001-04-19 Endorecherche, Inc. Selective estrogen receptor modulators in the treatment or reduction of the risk of acquiring hypertension, cardiovascular diseases, and insulin resistance
AU7993500A (en) * 1999-11-15 2001-05-30 New Millennium Pharmaceutical Research, Inc. Intranasal administration of raloxifene and tamoxifen
AU2609401A (en) * 1999-12-29 2001-07-09 Nicholas Kipshidze Apparatus and method for delivering compounds to a living organism
US6471979B2 (en) 1999-12-29 2002-10-29 Estrogen Vascular Technology, Llc Apparatus and method for delivering compounds to a living organism
WO2002056903A2 (en) * 2001-01-17 2002-07-25 Praecis Pharmaceuticals Inc. Methods for treating hormone associated conditions using a combination of lhrh antagonists and specific estrogen receptor modulators
UA75135C2 (en) * 2001-05-01 2006-03-15 Pfizer Prod Inc Dry granulation method for manufacturing pharmaceutical composition containing tetrahydronaphthalene-2-ol derivative and low dosage tablet compositions
JP2004531559A (ja) * 2001-05-22 2004-10-14 イーライ・リリー・アンド・カンパニー エストロゲン欠乏または内因性エストロゲンに対する異常な生理反応に関連する疾患を抑制するためのテトラヒドロキノリン誘導体
US7056931B2 (en) 2001-05-22 2006-06-06 Eli Lilly And Company 2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods
SK622004A3 (en) 2001-07-31 2004-08-03 Pfizer Prod Inc Pharmaceutical compositions, kits and methods comprising combinations of estrogen agonists/antagonists, estrogens and progestins
ATE433322T1 (de) 2002-07-22 2009-06-15 Lilly Co Eli Selektive östrogenrezeptor modulatoren, die eine phenylsulfonyl-gruppe enthalten
RU2666530C2 (ru) * 2012-01-12 2018-09-11 Йейл Юниверсити Соединения и способы усиления деградации белков-мишеней и других полипептидов с помощью е3 убиквитин лигазы
WO2014066695A1 (en) 2012-10-24 2014-05-01 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating estrogen-related medical disorders
ES2774935T3 (es) * 2012-10-24 2020-07-23 Univ Illinois Composiciones y métodos para tratar trastornos médicos relacionados con estrógeno
JP6644268B2 (ja) * 2018-03-22 2020-02-12 横浜ゴム株式会社 タイヤ用ゴム組成物及びスタッドレスタイヤ
CN112424205B (zh) * 2018-07-12 2023-10-31 伊莱利利公司 选择性的雌激素受体降解剂

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ200204A (en) * 1981-04-03 1985-05-31 Lilly Co Eli Benzothiophene derivatives and process for preparation
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US6399634B1 (en) * 1994-09-20 2002-06-04 Eli Lilly And Company Benzothiophene compounds, compositions, and methods
US6703407B1 (en) * 1994-09-20 2004-03-09 Eli Lilly And Company Benzofuran compounds, compositions, and methods
US5589482A (en) * 1994-12-14 1996-12-31 Pfizer Inc. Benzo-thiophene estrogen agonists to treat prostatic hyperplasia
US5552401A (en) * 1995-02-28 1996-09-03 Eli Lilly And Company 2-benzyl-3-arylbenzothiophenes
US5705507A (en) * 1995-03-10 1998-01-06 Eli Lilly And Company Aplha-substituted-3-benzyl-benzofurans
WO1996032937A1 (en) * 1995-04-21 1996-10-24 Eli Lilly And Company Benzothiophenes with novel basic side chains

Similar Documents

Publication Publication Date Title
JPH10204082A5 (enExample)
HUP0100615A2 (hu) Szubsztituált 2-(2,6-dioxo-3-fluoro-piperidin-3-il)-izoindolinok és ezek alkalmazása TNFalfa-szint csökkentésére
JP2002543183A5 (enExample)
RU99128073A (ru) Замещенные 2-(2,6-диоксопиперидин-3-ил)-фталимиды и -1-оксоизоиндолины и способ снижения уровней фноа
HUP0302943A2 (hu) Új heterociklusos vegyületek, előállításuk és alkalmazásuk gyógyszerekként, különösen antibakteriális szerekként
FR2569404A1 (fr) Nouveaux derives de 1,2-benzisothiazol-3-ylpiperazine, compositions pharmaceutiques contenant de tels composes et leurs procedes de preparation
CA2270086A1 (fr) Nouveaux derives benzothiopheniques, benzofuraniques et indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
KR960706477A (ko) 신규한 이미다졸 유도체 및 이의 제조방법(Novel imidazole derivative and process for producing the same)
RU2008119651A (ru) Производные дикарбоновых кислот и их применение
NO176094C (no) Analogifremgangsmåte for fremstilling av ringsubstituerte 2-amino-1,2,3,4-tetrahydronaftalener
RU2001116117A (ru) Новые пиперазиновые и пиперидиновые соединения
JPH1036206A5 (enExample)
KR930703271A (ko) 퀴스퀄레이트 수용체에 대한 친화성이 있는 퀴녹살린 유도체
HUP9902111A2 (hu) Biciklusos aminok és N-oxidjaik, intermedierjeik, előállításuk és alkalmazásuk, a vegyületeket tartalmazó inszekticid, akaricid és nematocid készítmények
JP2001518468A5 (enExample)
ATE95816T1 (de) 2-((4-piperidinyl)methyl>-1,2,3,4tetrahydroisochinolin-derivate, ihre herstellung und ihre therapeutische verwendung.
RU2002112329A (ru) Новые фторалкилзамещенные циклотрисилоксаны, их использование для получения новых полимеров и новые полимеры
RU93005087A (ru) 3-(тиазолидинилбутил-4-пиперазинил)-ih-индазолы
DE69131057D1 (de) 3-[1,Thiazolidinylbutyl-4-piperazinyl]-1H-Indazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente
JP2001072649A5 (enExample)
AU7152094A (en) New 2(1H)-quinolone compounds, process for their preparationand the pharmaceutical compositions which contain them
NO173276C (no) Analogifremgangsm}te for fremstilling av terapeutisk aktive 1,4-disubstituerte-piperidinylderivater
HUP9701325A1 (hu) Új 2,3-benzodiazepin-származékok
EP1027055A4 (en) 3-CARBOYLKOXY-2,3-DIHYDRO-1H-PHENOTHIAZIN-4 (10H] -ONE DERIVATIVES
EP0877026A4 (en) SUBSTITUTED 6-R-1,3,4-THIADIAZINE-2-AMINES, THEIR USE AS ANESTHESIC, CARDIOVASCULAR AND HYPOMETABOLIC AGENTS, AND PHARMACEUTICAL COMPOSITION CONTAINING THEM