JPH10192364A - Chemical container provided with communicating means - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a chemical container where a pre-existed vial is used and also which is convenient, inexpensive and compact at the tie of substantially and easily executes the mixing operation of chemicals with a sterilization in a short time. SOLUTION: This chemical container includes a cap material 5 which is provided with the vial where the chemicals are contained, a holder which is fitted to the neck 12 of the vial 1, a packing 4 for executing sealing between the top surface 21 of the holder 2 and the vial 1, a calking frame 3 for adhesively fixing the holder in the neck 12 of the vial 1 and a communicating means (double ended needle) 6 which is slide-engaged with the outer peripheral part of the calking frame 3. Then, the cap material 5 is vertically sliding possible along the outer periphery of the calking frame 3 and a rubber stopper 13 of the vial 1 is pierced by the double ended needle 6 at the time of sliding the cap material 5 downwards.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a drug container, and more particularly to a drug solution used by mixing with other drugs, or a drug solution dissolved immediately before use with a dissolving solution, for example, an anticancer drug, an antibiotic, a blood product, etc. The present invention relates to a drug container for containing a powdered or freeze-dried drug, which is provided with a communication means convenient for mixing with another drug or a solution.

[0002]

2. Description of the Related Art Conventionally, in medical institutions such as hospitals, powdered preparations such as anticancer drugs, antibiotics, blood preparations, etc., or lyophilized preparations contained in containers such as vials have been used by directly injecting them into infusions. The mixing ratio is easy to change,
In addition, since there is a problem that the medicinal effect is reduced when stored as a liquid drug, this is dissolved immediately before use and used as an infusion solution for infusion treatment. This is performed by connecting the container and a container containing a solution for dissolving the drug using a double-ended needle or a connecting tool such as a connecting tube, and transferring the solution to the container containing the drug. However, this operation is complicated and time-consuming,
Since an operation of opening a hole for connection to a container containing a medicine is performed in the open air, there is a possibility that the medicine in the inside may be contaminated. Further, there is a similar problem when mixing a drug solution with another drug.

In order to solve such a problem, a drug container and a dissolving solution container are integrally assembled so that a drug and a dissolving solution can be aseptically mixed at the time of use. There have been proposed a large number of dissolving solution containers provided with a liquid container, drug containers provided with communication means, and the like. Among these proposals, as a medicine container provided with a communicating means, a bottle body, a capsule slidably mounted in an open neck of the bottle body, and an annular flow path of a cylindrical portion of the capsule are provided. An annular gasket attached, comprising a closing member attached to the bottom of the cylindrical portion of the capsule, wherein the capsule is slid to move the closing member downward, thereby allowing the outside and the inside of the bottle to communicate with each other. (Japanese Patent Publication No. 6-69474) and a cap member slidable in the vertical direction is attached to a vial container having a bottom in which a vial is stored, and a communicating means is arranged between the cap member and the mouth of the vial. And a device in which a rubber member at the mouth of a vial is pierced by a communicating means by pressing a cap member (Japanese Patent Laid-Open No. Hei 8-57019). It has been proposed.

[0004]

However, the former drug container disclosed in Japanese Patent Publication No. 6-69474 cannot use existing vials, and therefore requires a drastic change in the production line. JP-A-8-57019
Since the medicine container disclosed in the above publication has a form in which a vial is housed in a vial housing container, it is bulky as a whole, and further improvement in cost is required. The present invention has been made in view of the above circumstances, and can use an existing vial, and can perform a mixing operation of a medicine substantially aseptically, conveniently and easily, in a short time, and at a low cost and a compact medicine container. The purpose is to provide.

[0005]

The present invention has been made in view of the above circumstances, and as a result of intensive studies, has come to the conclusion that the above problem can be solved by attaching a cap member having a communicating means to a vial. That is, in order to solve the above-described problems, the present invention provides a vial containing a medicine and having a mouth closed with a rubber stopper, a holder attached to a neck of the vial, a top surface of the holder, and the vial. A packing for sealing the gap, a caulking frame for pressing the holder in the vial direction and tightly fixing the holder to the vial neck, and a communicating means substantially substantially airtightly slidably fitted to the outer peripheral portion of the caulking frame. The cap member is slidable vertically along the outer periphery of the caulking frame, and when the cap member is slid downward, the rubber stopper of the vial is moved by the communication means. It uses a drug container that can be pierced.

Here, it is preferable to use a double-ended needle as the communicating means. The double-ended needle is used as the cap member so that the double-ended needle projects from the center of the top surface of the cap member and the puncture needle above it projects outside the cap member. And the upper puncture needle is protected by a cap, or the double-ended needle is formed separately from the cap member and is held at the center of the top surface of the cap member. Is preferably employed. The holder may be provided with an annular projection on the contact surface with the packing. Also, a kickback preventing means for engaging the rubber stopper of the vial with the top surface of the holder after penetrating the vial with the double-ended needle to prevent kickback of the double-ended needle, and the double-ended needle is formed integrally with the cap member. In such a case, it is preferable to provide the double-ended needle on the top surface of the cap member, or on the hub of the double-ended needle when the double-ended needle is formed separately from the cap member. The boundary between the caulking frame and the cap member may be sealed with a breakable sheet so that the unopened cap member can be confirmed.

[0007]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Next, embodiments of the present invention will be described with reference to the drawings. FIG. 1 is a longitudinal sectional view showing a medicine container according to one embodiment of the present invention. FIGS. 2 and 3 are enlarged longitudinal sectional views and enlarged bottom views of the holder shown in FIG. 1, respectively, and FIGS. FIG. 6 is an enlarged vertical sectional view and an enlarged bottom view of the caulking frame shown in FIG. 1, FIGS. 6 and 7 are enlarged vertical sectional views and an enlarged bottom view of the packing shown in FIG. 1, and FIGS. 8 and 9 are caps shown in FIG. FIG. 10 is an enlarged vertical sectional view and an enlarged bottom view of the member and the double-ended needle, and FIG. 10 is a diagram illustrating the use of the drug container shown in FIG. FIG.
1 is a longitudinal sectional view showing another embodiment of the present invention, and FIG.
And FIG. 13 are enlarged longitudinal sectional views and enlarged bottom views of the cap portion of the cap member shown in FIG. 11, respectively. FIGS. 14 and 15 are enlarged longitudinal sectional views and enlarged bottom views of the double-ended needle shown in FIG. 11, respectively. FIG. 12 is a diagram illustrating the usage of the medicine container shown in FIG. 11.

As shown in FIGS. 1 and 11, a medicine container of the present invention comprises a vial 1 containing a medicine (not shown), a holder 2 attached to a neck 12 of the vial 1, and a A packing 4 for sealing between the top surface 21 of the holder 2 and the vial 1, a caulking frame 3 for fixing the holder 2 to the neck 12 of the vial 1, and a communication slide-fitted to the outer peripheral portion of the caulking frame 3. It comprises a cap member 5, 50 provided with means (double-ended needle) 6, 60. The cap members 5 and 50 are vertically slidable along the outer periphery of the caulking frame 3, and when the cap members 5 and 50 are slid downward, the vial 1
The rubber stopper 13 is pierced by the double-ended needles 6 and 60.

The medicine container shown in FIG. 1 employs a cap member 5 in which a double-ended needle 6 as a communicating means is integrally formed at the center of a top surface 51 thereof. The needle 61 is provided so as to protrude outside the cap member 5, and is protected by the cap 7. Further, the medicine container shown in FIG. 11 employs a cap member 50 in which a double-ended needle 60 formed separately from the cap member 50 is held at the center of the top surface thereof. It is housed and protected in the cap member 50.

The vial 1 is a bottomed container containing a medicine therein, and has a mouth portion 11 and a neck 12, and the mouth portion 11 is closed by a rubber stopper 13 and a flange 1 is provided on the outside thereof.
4 are provided. As the vial 1, any commercially available type can be used. The drug used in the vial 1 may be a liquid drug, a powdered or lyophilized drug such as an anticancer drug, an antibiotic, or a blood product. It may be a given drug.

The holder 2 is a member for pressing and fixing the packing 4 to the end face of the mouth portion 11 of the vial 1, and is formed in a cap shape with a flexible resin such as polypropylene, polyethylene, ABS resin, polyester or the like. .
The holder 2 has a top surface 21 as shown in FIGS.
And a skirt portion 22, and a central portion of the top surface 21 has a through hole 2 through which a lower puncture needle 62 of the double-ended needle 6 described later passes.
4 is provided, and an inner wall thereof is preferably provided with an annular rib 26 for ensuring a seal with the packing 4. The flange 1 of the mouth 11 of the vial 1 is provided on the inner wall of the lower end of the skirt 22.
4 are formed, and a plurality of slits 25 are provided from the lower end toward the top surface 21. The slit 25 is provided to allow the skirt portion 22 to bend outward so that the annular projection 23 can move downward beyond the flange 14 when the holder 2 is attached to the neck 12 of the vial 1. 10 to 10 are provided. Reference numeral 27 denotes an annular groove for temporarily fixing the caulking frame 3 to the holder 2.

The caulking frame 3 is a member for pressing the holder 3 in the direction of the vial 1 and firmly fixing the holder 3 to the neck 12 of the vial 1. The caulking frame 3 is formed in a cap shape with the same flexible resin as the holder 2. ing. The caulking frame 3 is shown in FIG.
As shown in FIG. 5, a top surface 31 and a skirt portion 32 are provided.
2 is provided with a through hole 34 for transmitting light. The skirt portion 32 has an annular projection 35 formed on the lower end inner wall thereof to engage with the lower end of the holder 2, and the top surface 31 and the outer wall of the skirt portion 32 adjacent thereto are
An annular inclined surface 33 that projects gently downwardly
Is provided. The inclined surface 33 is a portion that slide-fits with an inclined surface 53 of the cap member 5 described later.

The packing 4 is for sealing between the top surface 21 of the holder 2 and the end surface of the mouth of the vial 1. The packing 4 is made of a rubber elastic material, for example, butyl rubber, chlorinated butyl rubber, thermoplastic elastomer, or the like. Is formed. As shown in FIGS. 6 and 7, the packing 4 is provided with a through hole 41 at the center thereof for allowing the lower puncture needle 62 of the double-ended needle 6 to pass therethrough. An annular rib 42 is provided for improving the sealing performance with the end face.

The cap members 5 and 50 are substantially airtightly slidably fitted on the outer peripheral portion of the caulking frame 3 and are slidable vertically along the outer periphery of the caulking frame 3. The double-ended needles 6 and 60 as communication means are provided at the center of the 501. Then, the cap members 5, 50
Is slid downward, the rubber stopper 13 of the vial 1
Is pierced by the double-ended needles 6 and 60. As shown in FIG. 8 and FIG. 9, a double-ended needle 6 formed integrally with the cap member 5 can be used as the cap member. This is generally made of polypropylene, high-density polyethylene, ABS resin, or the like, and includes a top surface 51, a skirt portion 52, and a double-ended needle 6 integrally formed at the center of the top surface 51. Skirt part 5
An annular inclined surface 53 is provided on an inner wall of the lower end of the projection 2 so as to project gently in the direction of the top surface 51. The inclined surface 53 is a portion that slide-fits with the inclined surface 33 of the caulking frame 3 as described above for the caulking member 3. Here, the top surface 51 is provided with a hook 54 for engaging the rubber stopper 13 of the vial 1 with the top surface 21 of the holder 2 after penetrating with the lower puncture needle 62 to prevent kickback of the double-ended needle 6. It is preferred to provide. The shape of the hook 54 is shown in FIG.
Even if it is provided at the bottom of the recessed top surface 51 as shown in FIG.
May be provided on an engagement arm (not shown) provided vertically downward from. In the case of the concave top surface 51 as shown in FIG. 8, the annular groove 5 formed between the concave portion and the upper puncture needle 61.
5 can be used as a groove for mounting the cap 7. Further, the boundary between the cap member 5 and the caulking frame 3 (the portion expected at the seam) is sealed with a breakable sheet (not shown) so that the unopened cap member 5 can be confirmed. You may.

The double-ended needle 6 is formed integrally with the same material at the center of the top surface 51 of the cap member 5 and has an upper puncture needle 61 and a lower puncture needle 62. Upper puncture needle 6
1 protrudes outward from the top surface 51 of the cap member 5 and is usually protected by a cap 7 covered by the cap member 5. Reference numeral 63 denotes a fitting portion of the upper puncture needle 61 with the cap.

FIGS. 12 and 1 show the cap member.
As shown in FIG. 3, a double-ended needle 60 formed separately from the cap member 50 can also be employed. This one is
Generally, it is made of polypropylene, polyethylene, ABS resin, polyester, or the like, and has a top surface 501 and a skirt portion 502. On the inner wall at the lower end of the skirt portion 502, there is provided an annular inclined surface 503 that projects gently inclining in the direction of the top surface 501 (this inclined surface 503 is similar to the annular groove 53 shown in FIGS. 8 and 9). Things). A cylindrical portion 504 for accommodating the upper puncture needle 601 is provided at the center of the top surface 501 of the cap member 50, and a base for holding the double-ended needle 60 concentrically with the cylindrical portion 504. A double-ended needle holder 505 is provided. Reference numeral 506 denotes a projection formed radially outside the double-ended needle holding portion 505 so as to abut the top surface 21 of the holder 2 when the rubber stopper 13 of the vial 1 is pierced by the double-ended needle 60. Usually, three to six are provided. The height of the radial projection 506 is such that when the radial projection 506 collides with the top surface 21 of the holder 2, the hook 604 of the double-ended needle 60 described later is used.
Are engaged with the inner wall of the top surface 21 of the holder 2.

The double-ended needle 60 is housed inside the cap member 50 and is held by being fitted to the double-ended needle holding portion 505. The double-ended needle 60 is generally made of a synthetic resin such as polypropylene, high-density polyethylene, or ABS resin, and includes upper and lower puncture needles 601 and 602 and a hub 603 as shown in FIGS. Is preferably provided with a plurality of engagement arms 605. The engagement arm 605 is a flexible protrusion extending vertically from the hub 603 in the direction of the lower puncture needle 602, and a hook 604 is provided on the outside of the distal end.
The hook 604 is the same as the hook 54 in FIGS. 8 and 9. After the rubber stopper 13 of the vial 1 is pierced by the lower puncture needle 602, the hook 604 engages with the top surface 21 of the holder 2 to kick back the double-ended needle 60. Has the function of preventing The number of the engaging arms 605 is usually three to four, and the length of the engaging arms 605 is determined when the lower puncture needle 602 pierces the rubber stopper 13 of the vial 1 (the radial projection 506 is Face 2
Hook 604 is in holder 2
Is determined so as to engage with the top surface 21.

Next, the use of the medicine container of the present invention will be described with reference to the drawings. In the case of the medicine container as shown in FIG. 1, when the cap member 5 is pushed downward from above the cap 7, the cap member 5 slides down along the outer wall of the caulking frame 3, and the lower puncture of the double-ended needle 6 is performed. Needle 62 is vial 1
The rubber plug 13 is pierced to obtain a state as shown in FIG. At this time, the hook 54 of the cap member 5 is engaged with the top surface 21 of the holder 2 to prevent kickback of the double-ended needle 6. If the cap 7 is removed from the medicine container in this state to expose the upper puncture needle 61, the upper puncture needle 61
Can be pierced through a rubber stopper or the like of a container containing another chemical solution to substantially aseptically mix the drug and the chemical solution.

In the case of a medicine container as shown in FIG.
When the cap member 50 is pushed downward, the cap member 50 slides downward along the outer wall of the caulking frame 3, and the lower puncture needle 602 of the double-ended needle 60 housed and held in the cap member 50 is moved to the rubber stopper 13 of the vial 1. 16 through FIG.
The state shown in FIG. At this time, the hook 604 of the double-ended needle 60 is engaged with the top surface 21 of the holder 2 to prevent the double-ended needle 60 from kicking back. When the cap member 50 is removed from the medicine container in this state and the upper puncture needle 601 is exposed, the upper puncture needle 601 is pierced through a rubber stopper of a container containing another medicinal solution to substantially aseptically mix the medicament and the medicinal solution. Mixing can be performed.

[0020]

As is apparent from the above description, the drug container of the present invention has a structure in which the cap member provided with the direct communication means is attached to the vial so as to be slidable in the vertical direction. The existing vial can be used by appropriately selecting the size.Since the rubber stopper of the vial can be easily pierced by the communication means by pressing down the cap member, the dissolving operation of the drug is easy and substantially effective. Since it can be performed aseptically and the number of parts can be reduced, it is possible to provide effects such as providing a medicine container at low cost. Also, by sealing the boundary between the caulking frame and the cap member with a breakable sheet,
The unopened cap member can be confirmed.

[Brief description of the drawings]

FIG. 1 is a longitudinal sectional view showing a medicine container according to one embodiment of the present invention.

FIG. 2 is an enlarged vertical sectional view of the holder shown in FIG.

FIG. 3 is an enlarged bottom view of the holder shown in FIG. 1;

FIG. 4 is an enlarged vertical sectional view of the caulking frame shown in FIG.

FIG. 5 is an enlarged bottom view of the caulking frame shown in FIG.

FIG. 6 is an enlarged vertical sectional view of the packing shown in FIG. 1;

FIG. 7 is an enlarged bottom view of the packing shown in FIG.

FIG. 8 is an enlarged vertical sectional view of the cap member and the double-ended needle shown in FIG. 1;

FIG. 9 is an enlarged bottom view of the cap member and the double-ended needle shown in FIG. 1;

FIG. 10 is an explanatory diagram of a use state of the medicine container shown in FIG. 1.

FIG. 11 is a longitudinal sectional view showing another embodiment of the present invention.

12 is an enlarged vertical sectional view of the cap member shown in FIG.

13 is an enlarged bottom view of the cap member shown in FIG.

14 is an enlarged vertical sectional view of the double-ended needle shown in FIG.

15 is an enlarged bottom view of the double-ended needle shown in FIG.

FIG. 16 is an explanatory view of a use state of the medicine container shown in FIG. 11.

[Explanation of symbols]

 Reference Signs List 1 vial 13 rubber stopper 2 holder 25 slit 26 annular rib 3 caulking frame 4 packing 5, 50 cap member 52, 502 skirt portion 54, 504 hook 6, 60 double-ended needle 7 cap

Claims (8)

[Claims] 1. A vial containing a medicine and having a mouth closed by a rubber stopper, a holder attached to a neck of the vial, a packing for sealing between a top surface of the holder and the vial, and the holder. A caulking frame that is pressed in the vial direction and tightly fixed to the neck of the vial, and a cap member provided with communication means, which is substantially airtightly slidably fitted to the outer peripheral portion of the caulking frame,
The cap member is slidable up and down along the outer periphery of the caulking frame. When the cap member is slid downward, the rubber stopper of the vial is pierced by the communication means. Drug container. 2. The medicine container according to claim 1, wherein the communicating means is a double-ended needle. 3. A double-ended needle is provided at the center of the top surface of the cap member.
3. The medicine container according to claim 2, wherein the upper puncture needle is integrally formed so as to protrude outside the cap member, and the upper puncture needle is protected by the cap. 4. A kickback preventing means is provided on the top surface of the cap member for preventing the kickback of the double-ended needle by engaging the rubber stopper of the vial with the double-sided needle and engaging with the top surface of the holder. The drug container according to claim 3. 5. The medicine container according to claim 2, wherein the double-ended needle is formed separately from the cap member, and is held at the center of the top surface of the cap member. 6. The double-ended needle hub is provided with kickback preventing means for engaging the rubber stopper of the vial with the double-ended needle and engaging the top surface of the holder to prevent kickback. 6. The drug container according to 5. 7. The drug container according to claim 1, wherein an annular projection is provided on a surface of the holder that contacts the packing. 8. The medicine container according to claim 1, wherein a boundary portion between the caulking frame and the cap member is sealed with a breakable sheet.