JPH08257101A - Dissolution liquid injection set - Google Patents

Abstract

PURPOSE: To provide an inexpensive dissolution liquid injection set which enables aseptic operation with easier operation and a simple structure and moreover, is portable. CONSTITUTION: When a cap member 3 is turned clockwise, a first slide protrusion 41 of a container carrier 4 slides along a spiral groove 33 of the cap member 3 while a second slide protrusion 42 of the container carrier 4 slides along a vertical groove 15 of a capsule 1. As a result, the container carrier 4 housing a dissolution liquid container 5 slides to the side of a medicine container 2 without turning and a double-headed needle 6 also slides together with the container carrier 4 reaching the medicine container 2. With the action of a communication interfering means 65 of the double-headed needle 6, first, a rubber cock 22 of the medicine container 2 is needled by a lower puncture needle 63 and then, a rubber cock of a dissolution liquid container 5 by an upper puncture needles 62. To release engagement between a cap member removing means 7 and the cap member 3, the cap member 3 is only turned counterclockwise.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a solution injection set. More specifically, the present invention relates to a solution injection set suitable for preparing a liquid drug by mixing a dry drug in a container with a solution in another container.

[0002]

2. Description of the Related Art Conventionally, in medical institutions such as hospitals,
It is used for intravenous injection as an infusion solution by dissolving a dry drug such as a powder drug or a freeze-dried drug contained in a drug container such as a vial. The operation of preparing such a dry preparation into a drug solution is performed by connecting a container containing a drug and a container containing a solution for dissolving the drug using a connecting tool such as a double-ended needle or a connecting pipe, and then dissolving the drug. This is done by transferring the liquid to a container containing the drug. However, this operation is complicated and time-consuming, and since the operation for opening a hole for connecting to the container containing the drug in the open air is performed, the drug inside may be contaminated. Therefore, as a solution to the above problems,
Japanese Patent Publication No. 61-501129 and Japanese Patent Laid-Open No. 2-1277.
Japanese Patent Application Laid-Open No. 3-37067, etc. for complete aseptic operation, and Japanese Patent Application Laid-Open No. 59-209.
No. 535, JP-A-62-137056, JP-A-2-4375, JP-A-60-210261, etc., a complete aseptic operation cannot be performed, but a combination of a drug and a solution is optional. , Etc., which enables substantially aseptic operation that can be selected, are proposed.

The one disclosed in JP-A-61-501129 is a capsule in which a drug container is housed and a flexible container in which a solution is housed are connected by a tube.
The medicine container and the flexible container are communicated with each other by the communication means provided in the tube, so that the medicine and the solution are aseptically mixed. Further, in the one disclosed in Japanese Patent Application Laid-Open No. 2-1277, the capsule containing the drug container is connected to the mouth of the dissolution liquid container at the joint portion thereof, and the communication sequence regulating means is provided on the joint portion side of the capsule. By interposing a communication means, after the drug container is pierced by the communication means, the dissolution liquid container is pierced and the two containers are communicated, so that the drug and the dissolution liquid are aseptically mixed. In Japanese Patent Laid-Open No. 3-37067, a drug container, a communicating means and a solution container are arranged in this order and sealed with a synthetic resin sheet, and a space between the drug container and the solution container is provided. The container support means is interposed from above the sheet, and the two containers are kept from approaching until the aseptic communication / mixing operation is performed.

On the other hand, in Japanese Patent Laid-Open No. 59-209535, a sealed first flexible container having a flexible wall member and a wall member of the flexible container are penetrated and fixed. You can
A second container having a removable stopper and a stopper removing member having a portion that engages with the stopper are formed. An apparatus has been disclosed in which a stopper is removed from a second container together with a sealing barrier of a flexible container so that the contents of the two containers can be mixed, as disclosed in JP-A-62-137056 and JP-A-23-137056. What is disclosed in Japanese Patent No. 4375 is an improvement of the second container. Also, Japanese Patent Application Laid-Open
The one disclosed in JP-A-210261 is disclosed in JP-A-59-20.
This is an improved version of the device disclosed in Japanese Patent No. 9535.

In the former device disclosed in Japanese Patent Publication No. 61-501129 and the like, since the drug container and the solution container are paired due to its constitution, the drug to be prepared is limited to one. Although it has a drawback of being stored, it enables complete aseptic operation. Further, the latter device disclosed in JP-A-59-209535 has a complicated mechanism and a stopper is There are many drawbacks such as being dropped in one container, and complete aseptic operation is not possible,
Since substantially aseptic operation is possible and the combination of the drug and the solution can be arbitrarily selected, it is necessary to properly use both of them as needed in the medical field.

[0006]

SUMMARY OF THE INVENTION The present invention has been made in view of the circumstances as described above, and is described in the above Japanese Patent Publication No. 61-50.
It is an object of the present invention to provide an inexpensive dissolution solution injecting set capable of performing aseptic operations equivalent to those of the apparatus disclosed in Japanese Patent No. 1129, etc., having a simple structure, easy to operate, and portable.

[0007]

In order to solve the above-mentioned problems, the present invention has a bottomed cylindrical capsule having a container holding means on its inner wall, and a drug container held and held upward in the capsule. A cap member that is rotatably attached to the opening of the capsule to seal the opening of the capsule; a container carrier having a mouth and a bottom that is housed and supported by the cap member; A solution container held and held in a container carrier, a communication means housed in a capsule so as to be located between the container carrier and a drug container, and held slidably in the vertical direction by the inner wall of the capsule, and the capsule. The cap member removing means provided in the cap member, the container carrier is rotated between the cap member, the container carrier and the capsule when the cap member is rotated. A guide means for sliding to the medicine container side is provided, and the cap member is rotated to move the dissolution liquid container in the direction of the medicine container together with the container carrier so that the dissolution liquid container and the medicine container are communicated by the communication means. The solution injection set consisting of is used.

Here, the guide means includes a plurality of parallel spiral grooves provided on the inner wall of the cap member, a plurality of vertical grooves provided on the inner wall of the capsule, and a plurality of first grooves provided on the outer wall of the container carrier. The first slide protrusion is slidably fitted in the spiral groove, and the second slide protrusion is slidably fitted in the vertical groove. In addition, a through hole may be provided at the bottom of the container carrier to facilitate removal of the solution container from the container carrier.To facilitate removal of the solution container and the drug container from the capsule, a communication means is provided at the time of completion of the communication operation. Providing first and second engaging means that engage with the mouth of the solution container and the mouth of the drug container, respectively, and can be easily released when the two containers in the engaged state are taken out of the capsule. Good. In such a releasable structure, for example, the first engaging means is composed of a flexible engaging arm provided on the surface of the hub, and the engaging arm engages with the mouth of the dissolution liquid container. And a second engaging means formed of a flexible engaging arm provided on the back surface of the hub, and the engaging arm engages with the mouth of the dissolution liquid container. This is achieved by forming protrusions. Also,
The engagement arm of the communication means is provided with a flexible communication blocking means for blocking the dissolution liquid container from being communicated by the communication means, and after the drug container is communicated by the communication means, the interference by the communication blocking means is released, The dissolution liquid container may be configured to communicate with each other.

[0009]

According to the above construction, when the cap member is rotated, for example, in the clockwise direction, the guide means causes the guide means to act, for example, the spiral groove of the cap member, the first and second slide protrusions of the container carrier, and the capsule. , The first slide projection of the container carrier slides along the spiral groove of the cap member, while the second slide projection of the container carrier slides along the vertical groove of the capsule. Therefore, the container carrier accommodating the dissolution liquid container slides to the drug container side without rotating. At this time, the communication means (for example, a double-ended needle) interposed between the solution container and the drug container also slides together with the container carrier to reach the drug container, and the edges of the both ends communicate the solution container and the drug container. After communication between the solution container and the drug container, remove the cap member from the capsule, then take out the integrated container carrier and drug container, and mix the solution in the solution container and the drug in the drug container well to remove the drug solution. It can be prepared. When performing drip treatment, the adjusted drug solution may be transferred to, for example, the dissolution liquid container side, and an infusion set or the like may be connected to the drug solution outlet.

[0010]

Embodiments of the present invention will now be described with reference to the drawings. 1 is a vertical cross-sectional view of a solution injection set according to an embodiment of the present invention, FIG. 2 is a vertical cross-sectional view of the drug container shown in FIG. 1, and FIG. 3 is a vertical cross-sectional view of the solution container shown in FIG. , Fig. 4
Is a longitudinal sectional view showing another embodiment of the solution container, and FIG.
6 is a vertical sectional view of the communicating means (double-ended needle) shown in FIG. 6, FIG. 6 is a bottom view of FIG. 5, FIG. 7 is a plan view of FIG. 5, FIG. 8 is a longitudinal sectional view showing another embodiment of the communicating means, and FIG. 1 is a vertical sectional view of the container carrier shown in FIG. 1, FIG. 10 is a bottom view of FIG. 9, FIG. 11 is a vertical sectional view of the capsule shown in FIG. 1, FIG. 12 is a plan view of FIG. 11, and FIG. 13 is a cap shown in FIG. Fig. 14 is a bottom view of Fig. 13, and Fig. 15 is Fig. 1
FIG. 16 is a plan view of the cap removing means shown in FIG.
It is a X-ray sectional view. As shown in FIG. 1, the dissolution liquid injection set of the present invention comprises a bottomed cylindrical capsule 1, a drug container 2 which is accommodated and held upward in the capsule 1, and a capsule 1 which is rotatably attached to the capsule 1. Cap member 3, container carrier 4 accommodated and supported by the cap member 3, solution container 5 accommodated and held by the container carrier 4, and slidably held between the container carrier 4 and the drug container 2. The communication means 6 is provided. By rotating the cap member, the container carrier 4 is slid to the drug container 2 side without rotating, and the solution container 5 housed and held in the container carrier 4 and the drug container 2 are communicated by the communication means 6. There is.

The capsule 1 is a bottomed cylindrical container for accommodating the drug container 2, the communication means 6, and at least the second engaging projection 42 portion of the container carrier 4, and is usually polyethylene, polypropylene, polyester, polyvinyl chloride. , Synthetic resin such as polycarbonate or ABS resin.
The capsule 1 has a bottom 11 and an opening 1 as shown in FIGS.
2, an annular projection 13 is formed on the outer wall of the opening 12 for engaging with a cap member removing means 7 described later. On the inner wall of the capsule 1, a plurality of vertical grooves 1 for fitting and sliding a second slide protrusion 42 of a container carrier 4 to be described later from the opening 12 toward the bottom 11 are formed.
5 are formed (two are formed in FIG. 11),
In the inner wall of the middle portion of the capsule 1, a vertical double-ended needle engaging groove 17 is formed in which an engaging arm 64 of a communicating means (to be referred to as a double-ended needle, hereinafter, a double-ended needle is normally used) 6 to be described later slides. (Four are formed in FIG. 11). The double-ended needle engagement groove 17 may be partially or wholly formed integrally with the vertical groove 15 (in FIG. 11, two double-ended needle engagement grooves are formed on the extension of the vertical groove). Plural engaging ribs 16 are formed in the lateral direction in the double-ended needle engaging groove 17 (four in FIG. 11 are formed), and the engaging arms 64 of the double-ended needle 6 are engaged to facilitate this. It works so as not to move downward. Engaging rib 1
6 also has a function of positioning the double-ended needle 6. Also,
The bottom 11 of the capsule 1 is provided with a drug container 2 toward the opening 12.
A plurality of vertical ribs 14 for holding the above are formed (four are formed in FIG. 11). Although one vertical groove 15 does not cause any problem, it is preferable to form two or more vertical grooves 15 in consideration of the stability of the container carrier 4.

The capsule 1 has a drug container 2, a double-ended needle 6 and a container carrier 4 containing a solution container 5 therein. As shown in FIG. 1, the drug container 2 and the double-ended needle 6 are arranged in this order, respectively. With the mouth 21 and its upper puncture needle 62 facing the opening 12 side (hereinafter referred to as the upper side), the container carrier 4 is
The solution container 5 (the mouth 51 of which is the second slide protrusion 42)
The second slide protrusion 42 side is directed to the bottom 11 side (hereinafter, referred to as the lower side) so that the mouth portion 51 of the container carrier 4 that faces the bottom side faces the bottom portion 11 side. It is housed. The drug container 2 is generally made of glass, and as shown in FIG. 2, the mouth portion 21 thereof is sealed with a sealing member such as a rubber stopper 22, and the rubber stopper 22 is further provided with a caulking member 23 made of aluminum or the like. Tightened, mouth 2
It is fixed at 1. A commercially available drug container can be used as the drug container 2, and the top surface of the caulking member 23 is removed when assembling the solution injection set, and a through hole is formed at a position for puncturing with the lower puncture needle 63 of the double-ended needle 6. 24 is formed. Although a dry preparation such as a powder preparation or a freeze-dried preparation is contained inside the drug container 2, it is omitted in the drawing.

The double-ended needle 6 used as the communication means is disposed between the drug container 2 and the solution container 5 as shown in FIG. 1, and is usually made of stainless steel (SUS104 is preferable) or synthetic resin. It consists of a canula and a synthetic resin hub. When sharpness is important, stainless steel canula is preferable, but a double-ended needle made of synthetic resin is preferable in consideration of the problem of disposal after use and the advantage that it can be integrally molded. As the synthetic resin, for example, ABS resin, high-density polyethylene, polycarbonate or the like is preferably adopted.

The double-ended needle 6 slides downward together with the container carrier 4 to pierce the rubber stopper 22 of the mouth portion 21 of the drug container 2, and further, the rubber stopper 5 of the mouth portion 51 of the solution container 5 described later.
2 and the closure membrane 53, the hub 61, the upper puncture needle 62 that penetrates the rubber stopper 52 of the dissolution liquid container 5, and the drug container 2 as shown in FIGS. The lower puncture needle 53 that pierces the rubber stopper 22 is provided, and the hub 6
An engaging arm 64 is provided at the tip of the hub 1 in the vertical direction of the hub 61. The engaging arm 64 is provided at its tip with a protruding portion 641 that comes into contact with the double-ended needle engaging groove 17 of the capsule 1 and slides along the same. The protruding portion 641 engages with the vertical groove 15. It is in releasable engagement with the rib 16.

On the surface of the hub 61 of the double-ended needle 6, a flexible communication blocking means 65 as shown in FIG. The communication blocking means 65 receives the mouth portion 51 of the dissolution liquid container 5 and interferes with the downward movement of the dissolution liquid container 5.
51 and a leg 652 having flexibility, and a swollen portion 651.
When the load related to (5) becomes a predetermined amount, the leg 652 bends outward to allow the mouth portion 51 of the dissolution liquid container 5 to move downward. Therefore, for example, the mouth portion 51 of the dissolution liquid container 5
So that the magnitude of the load that allows the downward movement of the solution is larger than the puncture resistance of the rubber stopper 22 of the drug container 2 by the lower puncture needle 63 of the double-ended needle 6 By selecting the shape of the part 653 and the thickness of the leg 652, the rubber stopper 5 of the dissolution liquid container 5 by the double-ended needle 6 is selected.
2 and the rubber plug 22 of the drug container 2 can be surely controlled in the piercing order. That is, unless the rubber stopper 22 of the drug container 2 is pierced by the lower puncture needle 63,
The upper puncture needle 62 can prevent the rubber stopper 52 of the dissolution liquid container 5 from being pierced.

The hub 61 of the double-ended needle 6 is engaged with the mouth portion 51 of the solution container 5 and the mouth portion 21 of the drug container 2 when the communication operation is completed, and the two containers 2 and 5 in the engaged state are encapsulated. You may provide the engaging means which can be easily released when it is taken out from 1. As such an engaging means, a structure including a flexible leg and a hook provided inwardly at the tip of the leg can be adopted. In FIG. 8, as such engaging means, first engaging means 66 engaging with the mouth portion 51 of the dissolution liquid container 5 is shown.
And the second engaging means 6 for engaging with the mouth portion 21 of the medicine container 2.
7 is shown. Although the first engaging means 66 can be provided separately, it is provided in the communication blocking means 65 in the figure. That is, the leg 652 is also a leg of the first engaging means 66, and the hook is formed by making the lower surface of the bulging portion 651 on the side of the upper puncture needle 62 at a right angle or an acute angle with the leg 652. The second engagement means 67 is a flexible leg 671.
And a hook 67 provided inward at the tip of the leg 671
It consists of two. Since these engaging means 66, 67 have flexible legs 652, 672, after the connected drug container 2, double-ended needle 6, and solution container 5 are taken out of the capsule 1, a hand, etc. It can be easily released with.

The container carrier 4 for accommodating and holding the dissolving liquid container 5 and sliding it to the double-ended needle 6 side is usually a cylindrical container made of the same synthetic resin as that of the capsule 1,
As shown in FIGS. 9 to 10, the cap member 3 described later is provided on the bottom.
A first slide protrusion 41 that slides along the spiral groove 33 is provided, and a second slide protrusion 42 that slides along the vertical groove 15 of the capsule 1 is provided at the mouth portion. A plurality of slits 43 are formed in the mouth so that the dissolving liquid container 5 can be easily inserted, and a through hole 44 is formed in the bottom so that the dissolving liquid container 5 can be easily taken out if necessary. The first slide protrusion 41 and the second slide protrusion 42 cooperate with the vertical groove 15 of the capsule 1 and the spiral groove 33 of the cap member 3 to be described later to cooperate with each other.
The guide means is configured to change the rotational movement of the above into a linear movement and slide the container carrier 4 straight to the double-ended needle 6 and the drug container 2 side. That is, in the case of the cap member 3 as shown in FIG. 13, when the cap member 3 is rotated clockwise, the first slide protrusion 41 of the container carrier 4 is fitted in the spiral groove 33 of the cap member 3,
The container carrier 4 tends to rotate together with the cap member 3. However, the second slide protrusion 4 of the container carrier 4
Since the container 2 is fitted in the vertical groove 15 of the capsule 1, the container carrier 4 cannot rotate, and the first slide protrusion 41 slides along the spiral groove 33 of the cap member 3 to allow the container carrier 4 to rotate. Move downward. The first
It is preferable to provide a plurality of the slide protrusions 41 and the second slide protrusions 42 (two are provided in FIG. 9), but the number may be one functionally.

A solution container 5 contained in a container carrier 4.
Is a press-deformable container in which the container body 55 is generally made of a relatively soft synthetic resin such as polyethylene, polypropylene, or polyester, and normally has a mouth part that also serves as a communication port and a drug solution outlet as shown in FIG. Those having 51 are adopted. The mouth portion 51 shown in FIG.
5 is formed by welding a closing member composed of a rubber stopper 52 and a pressing member 54 on the closing film 53 of No. 5.
It has a structure that can prevent elution from the solution into the solution. As shown in FIG. 4, the dissolution liquid container 5 may be provided with a chemical solution outlet 561 independently of the mouth portion 51, and the mouth portion 51 may be used as a communication port. In this case, the structure of the chemical solution outlet 561 may be the same as that of the mouth portion 51 and includes the closing film 563, the rubber stopper 562, and the pressing member 564, but after the cap member 3 is removed, it is contaminated by hands or the like. It is preferable to protect the rubber plug 562, which has a high risk of being damaged, by a cover sheet 57 such as a synthetic resin film.

The cap member 3 and the cap member removing means 7 are attached to the opening 12 of the capsule 1 in which the drug container 2, the communicating means (double-ended needle) 6 and the solution container 5 are housed in this order. The cap member removing means 7 may be configured to be attached from above the cap member 3 mounted in the opening 12 of the capsule 1, but in such a configuration, the cap member 3 is removed and the drug container 2 inside or the dissolution is dissolved. Since the liquid container 5 can be replaced (so-called tampering), the cap member removing means 7 is attached to the opening 12 of the capsule 1 as a preferable structure in FIG. 1, and the cap member 3 is forcibly fitted onto the opening 12 (so-called impossible). (Fitting) configuration is adopted.

The cap member 3 shown in FIGS. 13 to 14 is a cap member 3 having a falsification preventing function, and is used in combination with the cap member removing means 7 shown in FIGS. The cap member 3 includes a top surface 31 and a skirt portion 32.
The container member 4 is usually made of a synthetic resin similar to that of the container carrier 4 and has a cylindrical shape. The side wall of the skirt portion 32 is provided with a seal member 8 that hermetically seals between the cap member 3 and the capsule 1. Sealing member mounting groove 36 for
Are formed. As shown in FIG. 13, a spiral groove 33 that engages with the first slide protrusion 41 of the container carrier 4 is formed on the inner wall of the skirt portion 32 that is the side wall thereof, and the inner wall of the lower end portion of the skirt portion 32 is formed. Is provided with a protrusion 35 that is rotatably fitted in a groove 72 of a cap member removing means 7 described later. The spiral groove 33 can be formed by cutting the inner wall of the skirt portion 32.
It may be formed by providing a spiral ridge 34 as shown in FIG.

The cap member removing means 7 removes the cap member 3 from the capsule 1 so that the drug container 2, the double-ended needle 6 and the solution container 5 can be taken out.
It is formed in a ring shape as shown in FIGS. The cap member removing means 7 has, on its inner wall, an annular protrusion 71 that rotatably engages with the annular protrusion 13 of the opening 12 of the capsule 1, and its outer wall has a protrusion 35 on the inner wall of the lower end of the cap member 3. Is formed with a groove 72 that is rotatably engaged with.
The groove 72 is formed intermittently, and a portion of the groove cut 73 is formed in a shape in which an upper side wall portion forming the groove 73 is cut out, that is, a step shape, and the cap member 3 is formed.
The length of the protrusion 35 is shorter than the length of the groove cut 73. A locking projection 74 is provided between the groove 72 and the groove cut 73 that extend in the clockwise direction. When the cap member 3 is rotated in the clockwise direction, the projection 35 of the cap member 3 causes the cap member removing means 7 to move. Upon colliding with the locking projection 74, the cap member removing means 7 rotates together with the cap member 3. Then, while the cap member removing means 7 is rotating together with the cap member 3, the projection 35 of the cap member 3 is in the groove 72 of the cap member removing means 7, and then the cap member 3 is rotated.
When is turned counterclockwise, the protrusion 35
Is coming to. In this case, since the projection 35 is formed shorter than the groove cut 73, if the cap member 3 is moved upward when the projection 35 reaches the groove cut 73, the cap member 3 is removed.
It comes out of the.

Here, the cap member removing means 7 is
As shown in FIG. 1, most of the skirt portion 3 of the cap member 3
Since it is covered with the lower end of 2, it is impossible to rotate only the cap member removing means 7 by hand. Therefore, when removing the cap member 3, that is, the cap member 3
In order to prevent the cap member removing means 7 from rotating together with the cap member 3 when the is turned counterclockwise, the rotation preventing protrusion 75 is provided on the inner wall of the upper end portion of the cap member removing means 7.
18 provided on the outer wall of the opening 12 of the capsule 1
To engage. Then, the cap member 3 is turned clockwise to move the drug container 2 and the solution container 5 to the double-ended needle 6.
Only when the communication is completed, the ridge 18 of the capsule 1 gets over the rotation preventing projection 75, so that the cap member 3 cannot be removed from the capsule 1 unless the communication operation is completed. ing.

In FIGS. 15 to 16, the groove 72 and the groove break 7
The cap member removing mechanism composed of 3 and the locking projections 74 is formed on the outer wall of the cap member removing means 7, but the cap member removing mechanism is formed on the inner wall of the cap member removing means 7, and the skirt portion 3 of the cap member 3 is formed.
Protrusions formed on the outer wall of the lower end of 2 (not shown,
(Corresponding to the protrusion 35)). Further, a mechanism similar to the cap member removing mechanism is provided on the inner wall or the outer wall of the cap member 3, and is combined with a protrusion (not shown) similar to the protrusion 35 of the cap member 3 provided on the outer wall of the cap member removing means 7. You may However, in the cap member 3, the spiral groove 33 and the first slide protrusion of the container carrier 4 are engaged with each other,
Before use, it cannot rotate in the counterclockwise direction. However, when a cap member removing mechanism or a protrusion is provided on the outer wall of the cap member 3, only the cap member removing means 7 is turned counterclockwise. Since the cap member 3 can be taken out, it is necessary to separately provide means for preventing the cap member 3 from being removed before use.

Next, the use of the dissolution liquid injection set of the present invention will be described with reference to FIG. When the cap member 3 is rotated clockwise, the first slide protrusion 41 of the container carrier 4 is rotated.
Slides along the spiral groove 33 of the cap member 3, but the second slide protrusion 42 of the container carrier 4 slides along the vertical groove 15 of the capsule 1, so that the container carrier 4 containing the dissolving liquid container 5 It slides to the drug container 2 side without rotating. Then, the mouth portion 5 of the dissolution liquid container 5
When 1 collides with the communication blocking means 65 of the communication means (double-ended needle 6) interposed between this and the drug container 2, the double-ended needle 6 also slides together with the container carrier 4 to reach the drug container 2,
The rubber plug 22 of the drug container 2 is pierced by the lower puncture needle 63. At the position where the lower puncture needle 63 completes the insertion of the rubber stopper 22 of the drug container 2, the hub 61 of the double-ended needle 6 collides with the mouth portion 21 of the drug container 2 and the downward movement of the double-ended needle 6 is blocked. . At this time, the load applied to the communication blocking means 65 of the double-ended needle 6 by the mouth portion 51 of the dissolution liquid container 5 becomes large, so that the legs 652 of the communication blocking means 65 bend outward and the mouth portion 5
1 disengages from the bulging portion 651 of the communication blocking means 65. Then, the solution container 5 moves downward, and the rubber stopper 52 of the mouth portion 51 is pierced by the upper puncture needle 62. Thus, the drug container 2 and the solution container 5 are communicated with each other via the double-ended needle 6. After communication between the solution container 5 and the drug container 2, the cap member 3 can be easily released from the engagement by turning the cap member 3 counterclockwise. The engagement between the cap member removing means 7 and the cap member 3 is released, the cap member 3 is removed from the capsule 1, then the integrated container carrier 4, double-ended needle 6 and drug container 2 are taken out, and the solution container 5 The solution can be prepared by transferring the solution into the medicine container 2 through the solution passage 68 of the double-ended needle 6 and mixing the solution well with the medicine in the medicine container 2. When performing drip treatment, the adjusted drug solution may be transferred to, for example, the solution container 5 side, and an infusion set or the like may be connected to the drug solution outlet. Further, if a spray nozzle is attached to the mouth portion 21 of the medicine container 2, it can be used as a spray liquid. Needless to say, the transfer and mixing operations of the solution can be performed while the capsule 1 is contained. Further, it is possible to previously attach a spray nozzle to the solution container 5 instead of the chemical solution outlet 561.

[0025]

As is apparent from what has been described above, by adopting the solution injection set of the present invention,
The following effects can be achieved. Since aseptic operation is possible, infection due to bacterial contamination can be prevented. Since the operation is easy, it is possible to save the labor of the operation, to save the labor cost and to cope with the lack of manpower. By providing the communication blocking means, it is possible to regulate the communication order. In this case, since there is no fear of erroneous operation, the patient can operate with confidence, and it can be adopted as a home care product. A solution injection set can be provided at low cost. Since the communication mechanism between the drug container and the solution container is contained in the capsule, there is no fear of breakage and it can be carried.

[Brief description of drawings]

FIG. 1 is a vertical cross-sectional view of a solution injection set according to an embodiment of the present invention.

FIG. 2 is a vertical sectional view of the drug container shown in FIG.

FIG. 3 is a vertical cross-sectional view of the dissolution liquid container shown in FIG.

FIG. 4 is a vertical cross-sectional view showing another embodiment of the dissolution liquid container.

5 is a vertical cross-sectional view of the communication means (double-ended needle) shown in FIG.

FIG. 6 is a bottom view of FIG.

FIG. 7 is a plan view of FIG.

FIG. 8 is a vertical sectional view showing another embodiment of the communication means.

9 is a vertical cross-sectional view of the container carrier shown in FIG.

FIG. 10 is a bottom view of FIG. 9.

11 is a vertical cross-sectional view of the capsule shown in FIG. 1.

FIG. 12 is a plan view of FIG. 11.

13 is a vertical cross-sectional view of the cap shown in FIG. 1.

FIG. 14 is a bottom view of FIG. 13.

FIG. 15 is a plan view of the cap removing unit shown in FIG. 1.

16 is a cross-sectional view taken along line XX of FIG.

[Explanation of symbols]

 1 Capsule 13 Annular Protrusion 14 Vertical Rib 15 Vertical Groove 16 Engagement Rib 17 Double Needle Engagement Groove 18 Protrusion 2 Drug Container 3 Cap Member 33 Spiral Groove 35 Protrusion 36 Seal Member Mounting Groove 4 Container Carrier 41 First Sliding Protrusion 42 Second slide protrusion 5 Dissolution container 57 Cover sheet 6 Double-headed needle (communication means) 62 Upper puncture needle 63 Lower puncture needle 64 Engaging arm 65 Communication blocking means 66 First engaging means 67 Second engaging means 7 Cap member removing means 72 Groove 73 Groove break 74 Locking protrusion 75 Anti-rotation protrusion 8 Sealing member

 ─────────────────────────────────────────────────── ─── Continuation of front page (72) Inventor Takahide Okamoto 3-9-3 Honjo-nishi, Kita-ku, Osaka Inside Nissho Co., Ltd. (72) Inventor Osamu Sugita Chiyoda Town, Gunma Prefecture 2716 -1 Suntory Co., Ltd. Pharmaceutical Development Research Center (72) Inventor Yoshio Tsukada Era Group Gunma Prefecture Chiyoda Town Large Akaiwa character Kurakake 2716-1 Suntory Co., Ltd. Pharmaceutical Development Research Center (72) Nobuo Nakatsuka Kioicho, Chiyoda-ku, Tokyo No. 4-1 Suntory Co., Ltd.

Claims (6)

[Claims] 1. A bottomed cylindrical capsule having a container holding means on its inner wall, a drug container which is accommodated and held upward in the capsule, and a capsule rotatably attached to the opening of the capsule. A cap member for sealing the opening of the container, a container carrier having a mouth part and a bottom part which is accommodated and supported by the cap member, a dissolution liquid container accommodated and held in the container carrier, and a container carrier. The cap member and the container carrier are composed of a communication means which is housed in the capsule so as to be located between the drug containers and is held slidably in the vertical direction by the inner wall of the capsule, and a cap member removing means provided on the capsule. Between the capsules, a guide means for sliding the container carrier to the drug container side without rotating when the cap member is rotated is provided. A dissolution liquid injection set in which the dissolution liquid container is moved in the direction of the medicine container together with the container carrier by rotating the stopper member, and the dissolution liquid container and the medicine container are communicated by a communication means. 2. The guide means comprises a plurality of parallel spiral grooves provided on the inner wall of the cap member, a plurality of vertical grooves provided on the inner wall of the capsule, and a plurality of first grooves provided on the outer wall of the container carrier. And a second slide protrusion, and the first
2. The dissolution liquid injecting set according to claim 1, wherein the slide protrusion is slidably fitted in the spiral groove, and the second slide protrusion is slidably fitted in the vertical groove. 3. The dissolution liquid injecting set according to claim 1, wherein a through hole is provided at the bottom of the container carrier. 4. The communicating means engages with the mouth of the dissolution liquid container and the mouth of the drug container when the communicating operation is completed, and the two containers in the engaged state can be easily released when they are taken out from the capsule. The dissolving solution injecting set according to any one of claims 1 to 3, wherein the first and second engaging means are provided. 5. The first engaging means is composed of a flexible engaging arm provided on the surface of the hub, and the engaging arm is provided with an engaging projection for engaging with the mouth of the dissolution liquid container. In addition, the second engaging means is constituted by a flexible engaging arm provided on the back surface of the hub, and the engaging arm is provided with an engaging protrusion for engaging with the mouth portion of the dissolution liquid container. The solution infusion set described in. 6. An engagement arm of the communicating means is provided with a flexible communicating obstructing means for obstructing the dissolution liquid container from being communicated by the communicating means, and the communicating obstructing means is provided after the drug container is communicated by the communicating means. The dissolution liquid injection set according to claim 5, wherein the interference is released and the dissolution liquid container is communicated.