JP2013248122A - Chemical mixed injection instrument - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a chemical mixed injection instrument in a new structure, which allows puncture to a rubber stopper of a puncture needle in a state where a port part of a vial is accurately positioned so as to spread in an axis perpendicular direction to the puncture needle.SOLUTION: A chemical mixed injection instrument includes: a positioning means for positioning and holding a flange-like port part 92 of a vial 86 so as to spread in the axis perpendicular direction of a vial guide member 14; and a slide movement blocking means for blocking axial direction inward movement in which the vial guide member 14 approaches a partition wall 18 and then holding the vial 86 in the state of being isolated from a puncture needle 24 until the port part 92 of the vial 86 is positioned and held by the vial guide member 14. After the port part 92 of the vial 86 is positioned and held by the vial guide member 14, movement block by the slide movement blocking means is canceled, the axial direction inward movement of the vial guide member 14 is allowed, and the puncture with the puncture needle 24 is performed to the vial 86.

Description

  The present invention relates to a chemical solution co-infusion apparatus used for preparing a preparation by injecting a solution or the like into a vial containing a powder formulation and mixing the powder formulation and the solution.

  Traditionally, antibiotics and blood products, such as antibiotics and blood products that are chemically unstable and may be altered, are stored in a dry state in vials sealed with rubber stoppers. In addition, it is prepared by dissolving in a solution such as saline, glucose solution or the like, and administering it to a patient.

  As a chemical solution co-infusion apparatus that can easily prepare a preparation and a solution stored in a dry state in such a vial, for example, one described in Patent Document 1 (Japanese Patent Application Laid-Open No. 2004-194953) is available. Are known. The medicinal solution co-infusion apparatus includes a vial mounting part including a puncture needle provided on one side of the partition wall and a protruding puncture needle, and a cylindrical body part surrounding the puncture needle, and the other side of the partition wall. It has a main body having a projecting liquid dispensing device mounting port. Inside the puncture needle, one end opens on the surface of the puncture needle and the other end opens on the liquid agent discharge device mounting port, one end opens on the surface of the puncture needle and the other end of the main body portion. An air passage that opens to the outer peripheral surface is provided through. And, when mixing the chemical solution, a vial in which a fixed amount of dissolved solution previously stored in the interior from a device such as a syringe attached to the solution dispensing device mounting port is attached to the vial mounting part via the chemical solution passage This is carried out by mixing the preparation and the solution in this vial. And the chemical | medical solution after mixing is attracted | sucked with a syringe and extract | collected, and it dispenses etc. to a patient.

  By the way, as described in Patent Document 1, in such a chemical solution mixed injection device, in order to prevent injuries due to the puncture needle during use, contamination due to interference with other members of the puncture needle, etc., the main body portion A cylindrical vial guide member that protrudes and is held downward from the puncture needle is fitted on the lower end side of the slidable member so as to be slidable in the axial direction. If such a vial guide member is employed, since the vial guide member is disposed around the puncture needle, it is possible to advantageously reduce the possibility of injury due to the puncture needle during use or contamination of the puncture needle. it can.

  Moreover, as shown in FIG. 5 of Patent Document 1, a tapered portion is provided on the inner peripheral surface of the vial guide member, and the mouth portion of the vial sealed with a rubber stopper is centered at the central portion of the puncture needle. It is also possible to guide as is done. Thereby, the deterioration of the positioning workability between the puncture needle and the mouth of the vial due to the arrangement of the vial guide member around the puncture needle is also reduced.

  However, in such a conventional chemical solution co-infusion apparatus, although the vial mouth portion can be guided to the central portion of the vial guide member by the tapered portion of the vial guide member, the vial mouth portion is inclined in the axial direction. When pushed in a state, it was difficult to prevent the puncture needle from being pierced into the rubber stopper of the vial while maintaining such an inclination. In addition, since the puncture needle protrudes to the middle position of the tapered portion of the vial guide member, the puncture needle is punctured into the rubber stopper of the vial from the middle of the centering of the tapered portion. . As described above, if the puncture needle is punctured into the rubber stopper in a state where the positioning of the mouth portion of the vial with respect to the puncture needle is not accurately performed, coring may easily occur, and there is still room for improvement. .

JP 2004-194953 A

  The present invention has been made in the background of the above-mentioned circumstances, and the problem to be solved is that the puncture is performed in a state where the mouth of the vial is accurately positioned with respect to the puncture needle so as to spread in the direction perpendicular to the axis. An object of the present invention is to provide a chemical solution co-infusion device having a novel structure capable of puncturing a rubber stopper of a needle.

  Hereinafter, the aspect of this invention made | formed in order to solve such a subject is described. In addition, the component employ | adopted in each aspect as described below is employable by arbitrary combinations as much as possible.

  According to a first aspect of the present invention, there is provided a partition wall, a vial mounting part including a puncture needle protruding from one side of the partition wall and a cylindrical body part surrounding the puncture needle, and the other of the partition wall A body part having a liquid injection device mounting port projecting on the side of the puncture needle, and one end opened to the surface of the puncture needle through the inside of the puncture needle and the other end opened to the liquid injection device installation port A chemical solution passage, an air passage penetrating through the inside of the puncture needle and having one end opened on the surface of the puncture needle and the other end opened on the outer peripheral surface of the body portion, and the cylindrical portion of the body portion A cylinder that is slidably displaced in the axial direction and that protrudes outward in the axial direction from the tip of the puncture needle by moving outward in the axial direction away from the partition wall of the main body. A medicinal solution co-infusion device comprising: Positioning means for positioning and holding the flange-shaped mouth portion of the vial so as to spread in the direction perpendicular to the axis of the vial guide member, and until the mouth portion of the vial is positioned and held on the vial guide member, the vial guide member is Slide movement blocking means for holding the vial in a state of being separated from the puncture needle by blocking the axial inward movement approaching the partition wall, and positioning the mouth of the vial on the vial guide member After being held, the movement blocking by the slide movement blocking means is released, the movement of the vial guide member in the axially inward direction is allowed, and the puncture needle is punctured with respect to the vial. It is characterized by being.

  In this aspect, the positioning means holds the vial so that the mouth of the vial spreads in the direction perpendicular to the axis of the vial guide member. Thereby, the upper surface of the mouth part of the vial held by the vial guide member, that is, the surface of the rubber stopper can be arranged to face the puncture needle in a substantially horizontal state spreading in the direction perpendicular to the axis.

  Then, until the mouth of the vial is positioned and held with respect to the vial guide member, the movement of the vial guide member in the axial direction is blocked by the slide movement blocking means, and the slide movement blocking means after the positioning is completed. By releasing the movement blocking by the above, the vial guide member is allowed to move inward in the axial direction, and the puncture needle is punctured into the rubber stopper of the vial. Therefore, according to this aspect, the puncture needle is punctured with respect to the rubber stopper of the vial until the mouth portion (rubber stopper) of the vial is positioned and held at the normal position spreading in the direction orthogonal to the puncture needle. This can be completely prevented. As a result, it is possible to prevent the puncture needle from being punctured in an oblique state with respect to the rubber stopper of the vial, avoiding the occurrence of coring, and ensuring stable puncture operation. It becomes possible.

  Any positioning means may be used as long as the mouth of the vial can be positioned so as to spread in the direction perpendicular to the axis. For example, the positioning means may be arranged at a plurality of locations separated from each other in the circumferential direction of the peripheral wall of the vial guide member. Realized by a mechanism that supports the lower end surface of the flange-shaped mouth portion of the vial that is inserted into the inside of the vial guide member by overcoming the overhang protrusion and protruding at the same position in the axial direction. it can.

  Similarly, the slide movement preventing means may be any means that can prevent / allow slide movement before and after the completion of positioning of the vial opening with respect to the vial guide member, and may be provided integrally with the main body portion and the vial guide member. It may be provided separately. For example, a separate engagement member that can be engaged with the vial guide member is inserted from the outside to be engaged with the vial guide member, while preventing the vial guide member from moving inward in the axial direction until the positioning is completed, After the positioning is completed, the engaging member may be disengaged to allow the vial guide member to move inward in the axial direction.

  According to a second aspect of the present invention, in the medicinal-solution co-infusion apparatus according to the first aspect, the peripheral wall portion of the vial guide member is elastically deformed in the axial direction at a plurality of locations separated from each other in the circumferential direction. A piece is provided, and the elastic deflecting piece is connected and supported by an axially outer side end portion of the vial guide member, the proximal end portion of which is spaced axially outward from the puncture needle, The distal end portion of the intermediate portion extending inward in the axial direction from the base end portion is a free end that can be bent and deformed in the axial direction, and protrudes inward in the axial direction on the inner peripheral surface of the free end. The positioning means is configured by providing the mating protrusions at the same position in the axial direction.

  According to this aspect, when the mouth portion of the flange-shaped vial is inserted into the inside of the vial guide member and comes into contact with the engaging protrusion of the elastic deflecting piece, each elastic deflecting piece is moved out of the axial direction by the pushing force of the vial. Therefore, the mouth portion of the vial can be further pushed inward of the vial guide member. When the mouth of the vial is pushed inward in the axial direction beyond the engaging protrusion, the pushing force of the vial applied to the engaging protrusion is released, and the elastic bending piece is moved outward in the axial direction. The bending deformation is released, and the engagement protrusion elastically returns to the position where the lower end surface of the mouth portion of the flange-shaped vial is held. Here, since the engaging protrusions are provided at the same position in the axial direction, the vial mouth can be positioned and held stably so as to spread in the axial direction.

  In addition, it is preferable that the elastic bending pieces are spaced apart at equal intervals in the circumferential direction. Thereby, the mouth part of the vial can be stably positioned and maintained in a balanced manner, and the vial mouth part can be more reliably positioned so as to be horizontal in the direction perpendicular to the axis.

  According to a third aspect of the present invention, in the medicinal-solution mixed injection device according to the second aspect, the inner peripheral surface of the main body portion has a plurality of circumferential locations corresponding to the plurality of elastic bending pieces and an axial direction. At the same position, a locking step surface extending outward in the axial direction is provided, while a free end of the elastic bending piece is provided with a locking portion that can be locked to the locking step surface. Until the mouth of the vial is pushed into the inside of the vial guide member and positioned, the mouth of the vial is brought into contact with the engaging protrusion of the elastic deflecting piece, and the elastic deflecting piece Is bent outwardly in the direction perpendicular to the axis so that the locking portion is locked to the locking step surface to constitute the slide movement preventing means, while the mouth of the vial Can be pushed inward in the axial direction beyond the engagement protrusion. Thus, the bending deformation of the elastic bending piece outward in the axial direction is released, the engagement protrusion is elastically returned to the position holding the lower end surface of the flange-shaped vial mouth, and the mouth of the vial is While being positioned and supported by the engagement protrusion, the engagement of the engagement portion of the elastic bending piece is released from the engagement step surface of the main body, and the vial guide member moves inward in the axial direction. It is to be allowed.

  According to this aspect, using the bending deformation in the axial direction of the elastic bending piece provided at a plurality of locations in the circumferential direction, the amount of the inward insertion of the mouth of the vial into the axial direction with respect to the vial guide member is linked. The positioning means and the slide movement preventing means can be efficiently formed with a small number of parts.

  In short, the positioning means for positioning the mouth of the vial after the mouth of the vial gets over the engaging protrusion is realized by the engaging protrusion provided on the inner surface of the elastic deflecting piece, and the engaging protrusion of the vial mouth. By using the elastic deformation / restoration of the elastic bending piece before and after getting over, it is possible to switch between blocking and allowing the vial guide member to move in the axial direction by locking the locking portion to the locking step surface. Can do. Accordingly, the user simply pushes the mouth of the vial into the inside of the vial guide member, and the puncture is performed from the state where the vial mouth is positioned at a normal position extending in the direction perpendicular to the axis of the puncture needle. The needle can be punctured with certainty. Therefore, the occurrence of coring or the like can be advantageously prevented without requiring any complicated work from the user.

  According to a fourth aspect of the present invention, in the medicinal-solution co-infusion device according to the third aspect, the axially inward portion of the locking portion provided at the distal end portion of the free end of the elastic bending piece is further axial. A deformation restricting portion is formed so as to protrude inward, and the amount of deformation of the elastic bending piece outward in the axial direction is restricted by contact between the deformation restricting portion and the inner peripheral surface of the main body portion. It is something like that.

  According to this aspect, since the deformation restricting portion is provided at the tip of the free end of the elastic bending piece, excessive bending deformation of the elastic bending piece outward in the axial direction is prevented, and the elastic bending piece. Thus, it is possible to advantageously improve the durability and to quickly return the elastic flexible piece after the mouth of the vial gets over the engaging protrusion. Therefore, the slide movement preventing means can be reliably released after the mouth of the vial is positioned over the engaging protrusion.

  According to a fifth aspect of the present invention, in the drug solution co-infusion apparatus according to any one of the first to fourth aspects, the inner peripheral surface of the cylindrical portion of the main body portion and the outer peripheral surface of the peripheral wall portion of the vial guide member One of the ribs is provided with a rib extending in the axial direction, and the other of the inner peripheral surface and the outer peripheral surface is provided with a rib receiving groove for receiving the rib. By being accommodated in the groove, the main body and the vial guide member are positioned in the circumferential direction.

  According to this aspect, by fitting the rib provided between the contact surface of the main body portion and the vial guide member and the rib receiving groove, the main body portion and the vial guide member can be positioned in the circumferential direction. Even when the locking portion and the locking step surface are provided, their alignment can be achieved simultaneously by fitting the rib and the rib receiving groove.

  Further, since the rib extends in the axial direction, the sliding movement of the vial guide member in the axial direction can be stably achieved by being guided by the fitting between the rib and the rib housing groove.

  According to the present invention, the slide movement preventing means prevents the vial guide member from moving inward in the axial direction until the mouth of the vial is positioned and held with respect to the vial guide member. By releasing the movement blocking by the blocking means, the vial guide member is allowed to move inward in the axial direction, and the puncture needle is punctured into the rubber stopper of the vial. This completely prevents the puncture needle from being punctured with respect to the rubber stopper of the vial until the mouth portion (rubber stopper) of the vial is positioned and held at a normal position extending in a direction orthogonal to the puncture needle. Therefore, it is possible to reliably perform a stable puncturing operation without generating a coring or the like.

BRIEF DESCRIPTION OF THE DRAWINGS The perspective view of the chemical | medical solution mixed injection instrument as the 1st Embodiment of this invention. II-II sectional drawing in FIG. The perspective view of the main-body part in the chemical | medical solution mixed injection instrument shown in FIG. The bottom view of the main-body part. The perspective view of the vial guide member in the chemical | medical solution co-infusion apparatus shown in FIG. The perspective view different from FIG. 5 of the vial guide member shown in FIG. Explanatory drawing explaining the usage method of the chemical | medical solution co-infusion apparatus shown in FIG.

  Hereinafter, in order to clarify the present invention more specifically, embodiments of the present invention will be described in detail with reference to the drawings.

  First, the chemical | medical solution co-infusion apparatus 10 as the 1st Embodiment of this invention is shown in FIGS. The medicinal-solution co-injection device 10 includes a main body portion 12 having a substantially cylindrical shape as a whole, and a vial guide member 14 fitted in the main body portion 12 so as to be slidable in the axial direction.

  The main body 12 is made of a known material such as a synthetic resin material such as polypropylene, polyethylene, ABS resin, polycarbonate, or polystyrene, and has a substantially cylindrical cylindrical body 16. The cylindrical portion 16 is open at one end (lower side in FIG. 2) and is closed by a partition wall 18 whose other end (upper side in FIG. 2) extends in the direction perpendicular to the axis. It has a substantially bottomed cylindrical shape. A puncture needle 24 protrudes from one side (lower side in FIG. 2) of the partition wall 18, and a vial mounting portion 20 is formed in cooperation with the cylindrical body portion 16 surrounding the puncture needle 24. Has been. In addition, on the other side of the partition wall 18 (upper side in FIG. 2), a liquid injection / ejection device mounting port 22 to which a liquid injection / discharge device such as a syringe can be mounted protrudes. If necessary, a male screw is formed on the outer circumferential surface of the liquid agent discharging device port 22.

  The puncture needle 24 protrudes from the substantially central portion of the partition wall 18 into the cylindrical body portion 16 and extends on the central axis of the cylindrical body portion 16. The protruding dimension of the puncture needle 24 is about half of the axial dimension of the cylindrical body portion 16, and the distal end portion 26 of the puncture needle 24 is provided through the vial guide member 14 assembled at the lowermost end of the main body portion 12. Further, it is prevented from projecting below a central hole 54 described later. The distal end portion 26 of the puncture needle 24 has a needle shape so that it can penetrate a rubber stopper 94 of a vial 86 described later.

  Inside the puncture needle 24, a chemical liquid passage 28 is formed. The drug solution passage 28 is a communication passage that extends through the inside of the puncture needle 24 and the partition wall 18 and extends in the axial direction of the puncture needle 24. The medicinal solution passage 28 is opened at the surface of the puncture needle 24 at the first opening 30 formed at one end portion at the distal end portion 26 of the puncture needle 24 and the second opening portion 32 at the other end portion. Are opened in the liquid dispensing device mounting port 22. In addition, the filter 34 is attached to the 2nd opening part 32 from the liquid agent injection | pouring device mounting port 22 side. Thus, when the mixed drug solution 100 to be described later is pulled out from the vial 86 to a liquid drug dispensing device such as a syringe, the mixed drug solution 100 is filtered by the filter 34 to remove foreign matters such as rubber pieces mixed in the mixed drug solution 100. I can do it.

  Here, the main body 12 is formed with a connecting tube 36 that extends in the direction perpendicular to the puncture needle 24 from the puncture needle 24 on the surface of the partition wall 18 on the vial mounting portion 20 side. The connecting tube 36 has a hollow tube shape, and one end is opened on the outer peripheral surface of the cylindrical body 16 and the other end is connected to the puncture needle 24.

  An air passage 40 extending in parallel with the drug solution passage 28 is formed through the puncture needle 24. The air passage 40 has one end opened to the surface of the puncture needle 24 through an inner opening 42 formed at the distal end portion 26 of the puncture needle 24, and the other end to the inside of the connecting tube 36. The outer opening 44 formed on the outer peripheral surface of the main body 12 through the connecting pipe 36 is opened on the outer peripheral surface of the main body 12. A hydrophobic filter 46 is provided in the vicinity of the outer opening 44 on the path of the air passage 40. Thereby, when outside air flows into the vial 86 to be described later through the air passage 40, it is possible to prevent the outside air from being filtered by the filter 46 and to mix germs, foreign matters, etc. contained in the outside air into the vial 86.

  Further, as shown in FIGS. 3 and 4, the inner peripheral surface of the cylindrical body portion 16 of the main body portion 12 has a plurality of locations in the circumferential direction corresponding to a plurality of elastic bending pieces 58 described later and the same position in the axial direction. Further, a locking step surface 48 that extends outward in the axial direction is provided. Further, an annular groove portion 49 extending in the circumferential direction is provided on the inner peripheral surface of the cylindrical body portion 16 of the main body portion 12.

  On the other hand, the vial guide member 14 is formed of an arbitrary synthetic resin material or the like, similar to the main body portion 12, and has a bottomed cylindrical shape with one end (lower in FIGS. 5 and 6) opened. The bottom portion 50 and the cylindrical peripheral wall portion 52 are provided. A central hole 54 is provided in the center of the bottom 50. Further, the peripheral wall portion 52 extends in an inverted U shape from an axially intermediate portion of the peripheral wall portion 52 to the inside of the bottom portion 50 at a plurality of locations (four locations in the present embodiment) that are equally spaced in the circumferential direction. A cutout portion 56 is formed. In the region surrounded by the notch 56, four elastic deflecting pieces 58, 58, 58, 58 are provided. The elastic deflecting piece 58 has a base end portion 60 connected to and supported by an end portion on the axially outer side (lower side in FIGS. 5 and 6) of the vial guide member 14, and inward in the axial direction from the base end portion 60. The tip 64 extends from the intermediate portion 62 extending upward (in FIGS. 5 and 6) to a free end that can be bent and deformed in the axial direction, and protrudes inward in the axial direction on the inner peripheral surface of the free end. An engaging projection 68 is formed. In addition, all the engagement protrusions 68 of each elastic bending piece 58 are provided in the same position in the axial direction. A stepped locking portion 70 extending in the circumferential direction is provided at the distal end portion 64 of the elastic bending piece 58. In addition, a deformation restricting portion 72 is configured such that an inner portion in the axial direction of the locking portion 70 provided at the distal end portion 64 of the elastic bending piece 58 further protrudes inward in the axial direction.

  Further, the peripheral wall portion 52 of the vial guide member 14 is formed with circumferential protrusions 73 protruding on the outer peripheral surface at four locations near the bottom portion 50 where the elastic bending piece 58 is not formed.

  In addition, an axially extending rib 74 is provided on the inner peripheral surface of the cylindrical body portion 16 of the main body portion 12 (see FIG. 3), while the outer peripheral surface of the peripheral wall portion 52 of the vial guide member 14 is A rib accommodating groove 76 for accommodating the rib 74 is provided (see FIG. 5), and the main body 12 and the vial guide member 14 are positioned in the circumferential direction by accommodating the rib 74 in the rib accommodating groove 76. It has become. In the present embodiment, four ribs 74 and rib housing grooves 76 are provided at equal intervals in the circumferential direction.

  The vial guide member 14 is inserted into the cylindrical body portion 16 of the main body portion 12. When the bottom 50 side of the vial guide member 14 is pushed inwardly from the open end 80 of the cylindrical portion 16 of the main body 12, the circumferential protrusion 73 of the vial guide member 14 is fitted into the annular groove 49 of the main body 12. Temporarily locked. At this time, as shown in FIG. 2, the opening end portion 80 of the cylindrical body portion 16 and the opening end portion 82 of the vial guide member 14 are positioned so as to be flush with each other, from the partition wall 18 of the main body portion 12. The vial guide member 14 is temporarily fixed at a position farthest away outward in the axial direction. Until the concave-convex engagement between the circumferential protrusion 73 and the annular groove 49 is released by a predetermined push-in, the slide of the vial guide member 14 into the cylindrical portion 16 is prevented and the cylindrical portion of the vial guide member 14 is prevented. Exit from 16 is prevented.

  Thus, in a state where the vial guide member 14 is temporarily fixed at the outermost position (lower end position) in the axial direction, the distal end portion 26 of the puncture needle 24 penetrates the vial guide member 14 assembled to the main body portion 12. It is positioned so as not to protrude through the central hole 54 provided. That is, the vial guide member 14 protrudes outward in the axial direction from the distal end portion 26 of the puncture needle 24.

  Next, a method for co-injecting and preparing a chemical solution using such a chemical solution co-infusion apparatus 10 will be described with reference to FIG. First, the medicinal-solution co-injection device 10, a vial 86, and a syringe (not shown) as a liquid agent discharging device are prepared.

  The vial 86 includes a glass bottle 90 and a rubber stopper 94 that closes the flange-shaped mouth portion 92 of the glass bottle 90. Inside the vial 86, a solid medicine 96 such as a freeze-dried protein preparation is enclosed.

  7 (a) and 7 (b), a vial guide in which the vial 86 is assembled to the main body 12 with a syringe (not shown) connected to the solution dispensing device mounting port 22 of the drug solution co-injection device 10. Insert into member 14. The syringe is filled with a solution such as distilled water or physiological saline. The posture of the chemical solution injection device 10 is not particularly limited, but preferably, the vial 86 is placed on a desk or the like, and the vial guide member 14 assembled to the main body 12 from above the vial 86 is mounted. To do. As shown in FIG. 7 (b), the flange-shaped mouth portion 92 of the vial 86 is inserted into the vial guide member 14 assembled to the main body portion 12, and contacts the engaging protrusion 68 of the elastic bending piece 58. Upon contact, the elastic bending piece 58 is bent and deformed outward in the axial direction by the pushing force of the vial 86. Accordingly, the flange-shaped mouth portion 92 of the vial 86 can be further pushed into the inside of the vial guide member 14, and the locking portion 70 provided on the peripheral wall portion of the elastic deflecting piece 58 is provided inside the main body portion 12. The vial guide member 14 can be prevented from moving inward in the axial direction by being locked by a locking step surface 48 provided on the peripheral surface. That is, in this embodiment, the slide movement preventing means is configured by the locking portion 70 of the elastic bending piece 58 and the locking step surface 48 of the main body portion 12. Until the flange-shaped mouth portion 92 of the vial 86 is inserted into the vial guide member 14 and abuts against the engaging projection 68 of the elastic deflecting piece 58, the circumferential projection 73 and the cylindrical portion of the vial guide member 14 are in contact. The vial guide member 14 is temporarily fixed at the lower end position of the cylindrical body portion 16 by the concave-convex engagement of the sixteen annular groove portions 49. After that, even if a strong pushing force is applied to push the vial 86 until the mouth portion 92 of the vial 86 gets over the elastic bending piece 58, the axial direction of the vial guide member 14 is caused by the engagement of the locking portion 70 and the locking step surface 48. Inward slide movement is stably prevented.

  Here, a deformation restricting portion 72 is provided at the distal end portion 64 of the free end of the elastic bending piece 58, and the amount of bending deformation of the elastic bending piece 58 outward in the axial direction is the inner circumference of the deformation restricting portion 72 and the main body portion 12. It is regulated by the contact of the surfaces. Therefore, excessive bending deformation of the elastic bending piece 58 is prevented.

  Then, as shown in FIG. 7C, when the flange-shaped mouth portion 92 of the vial 86 is pushed inward in the axial direction beyond the engagement protrusion 68 of the elastic deflecting piece 58, it is added to the engagement protrusion 68. The pushing force of the vial 86 that has been released is released, and the bending deformation of the elastic bending piece 58 in the axially outward direction is released, and the engaging projection 68 holds the lower end surface of the flange-shaped mouth portion 92 of the vial 86. Returns to the elastic position. Here, since the engaging protrusions 68 are provided at the same position in the axial direction, the flange-shaped mouth portion 92 of the vial 86 can be stably positioned and spread so as to spread in the axial direction. That is, in the present embodiment, the elastic deflecting piece 58 and the engaging projection 68 constitute a positioning means. Further, since the engagement of the elastic bending piece 58 with the locking step surface 48 of the main body 12 by the locking portion 70 is released, the movement of the vial guide member 14 in the axial direction can be permitted. is there. In short, the slide movement preventing means by the locking portion 70 and the locking step surface 48 is the axial direction in which the vial guide member 14 approaches the partition wall 18 until the mouth portion 92 of the vial 86 is positioned and held on the vial guide member 14. While the vial 86 is held away from the puncture needle 24 by preventing inward movement, the flange-shaped mouth portion 92 of the vial 86 is positioned and held by the engaging protrusion 68 of the elastic deflecting piece 58. The movement of the vial guide member 14 in the axially inward direction is automatically allowed. Therefore, using the bending deformation in the axial direction of the elastic deflecting pieces 58 provided at a plurality of locations in the circumferential direction, the amount of pushing inward in the axial direction of the mouth portion 92 of the vial 86 with respect to the vial guide member 14 is linked. The positioning means and the slide movement preventing means can be efficiently formed with a small number of parts. As shown in FIG. 7C, the peripheral shape of the vial guide member 14 is maintained even when the mouth portion 92 of the vial 86 is pushed inward in the axial direction beyond the engagement protrusion 68 of the elastic deflecting piece 58. The vial guide member 14 is temporarily fixed at the lower end position of the cylindrical body portion 16 by the concave and convex engagement between the protrusion 73 and the annular groove portion 49 of the cylindrical body portion 16.

  Then, as shown in FIG. 7 (d), the entire vial guide member 14 is brought into contact by applying a pushing force that can release the concave-convex engagement between the circumferential protrusion 73 and the annular groove 49 to the vial guide member 14. The vial 86 is pushed into the vial mounting portion 20 until it abuts on the outer peripheral surface of the tube body 36. As a result, the distal end portion 26 of the puncture needle 24 penetrates the rubber stopper 94 of the vial 86, whereby the drug solution passage 28 and the air passage 40 communicate with the inside of the vial 86. As a result, the inside of the vial 86 and the inside of the syringe (not shown) communicate with each other through the chemical liquid passage 28. Then, a solution in a syringe (not shown) is injected into the vial 86 through the chemical solution passage 28. As a result, the solution and the drug 96 are mixed in the vial 86, and the mixed drug solution 100 is mixedly prepared.

  Finally, the mixed chemical solution 100 prepared in the vial 86 is turned through the chemical solution passage 28 by reversing the posture of the chemical solution injection device 10 and the vial 86 shown in FIG. Aspirated into syringe.

  As described above, according to the medicinal-solution mixed injection device 10 in the present embodiment, the lower end surface of the flange-shaped mouth portion 92 of the vial 86 can be held by the engagement protrusion 68 of the elastic deflecting piece 58 serving as a positioning means. Since the engaging protrusions 68 are provided at the same position in the axial direction, the flange-shaped mouth portion 92 of the vial 86 can be stably positioned and held so as to spread in the axial direction. Further, until the flange-shaped mouth portion 92 of the vial 86 is positioned and held, the vial guide member 14 is moved inward in the axial direction by the engagement of the locking portion 70 serving as the slide movement preventing means and the locking step surface 48. After the positioning is completed, the movement blocking by the slide movement blocking means is released, so that the vial guide member 14 is allowed to move inward in the axial direction, and the puncture needle 24 is attached to the rubber plug 94 of the vial 86. It is designed to be punctured. Therefore, until the rubber plug 94 of the vial 86 is positioned and held at a normal position extending in a direction orthogonal to the puncture needle 24, it is completely possible that the puncture needle 24 is punctured with respect to the rubber plug 94 of the vial 86. It is possible to prevent the occurrence of coring caused by the puncture needle 24 being punctured with the rubber plug 94 of the vial 86 obliquely, and a stable puncture operation can be performed reliably. Become.

  Note that the engagement protrusions 68 of the elastic bending piece 58 are preferably spaced apart at equal intervals in the circumferential direction. Accordingly, the flange-shaped mouth portion 92 of the vial 86 can be stably positioned with good balance, and the flange-shaped mouth portion 92 of the vial 86 is more reliably positioned so as to be horizontal in the axial direction. be able to.

  Further, positioning means for positioning after the flange-shaped mouth portion 92 of the vial 86 has passed over the engaging protrusion 68 is realized by the engaging protrusion 68 of the elastic deflecting piece 58, and the flange-shaped mouth portion 92 of the vial 86 is formed. By skillfully utilizing the elastic deformation / return of the elastic bending piece 58 before and after the engagement protrusion 68 is passed, the vial guide member 14 is axially inwardly engaged by the engagement with the engagement step surface 48 of the engagement portion 70. It is possible to switch between blocking and allowing movement. Accordingly, the user simply pushes the flange-shaped mouth portion 92 of the vial 86 into the inside of the vial guide member 14, and the flange-shaped mouth portion 92 of the vial 86 is moved straight to the axis of the puncture needle 24. The puncture needle 24 can be punctured reliably from a state where the puncture needle 24 is positioned at a regular position spreading in the direction, and the occurrence of coring or the like can be advantageously prevented.

  Further, by fitting the rib 74 and the rib receiving groove 76 provided between the contact surfaces of the main body 12 and the vial guide member 14, the main body 12 and the vial guide member 14 can be positioned in the circumferential direction. For example, even when the locking portion 70 and the locking step surface 48 are provided, their alignment can be achieved simultaneously by fitting the rib 74 and the rib receiving groove 76. Further, since the rib 74 extends in the axial direction, the slide movement in the axial direction of the vial guide member 14 can be stably achieved by being guided by the fitting of the rib 74 and the rib receiving groove 76.

  As mentioned above, although embodiment of this invention was explained in full detail, this invention is not limited by the specific description. For example, any positioning means may be used as long as it can position the flange-shaped mouth portion 92 of the vial 86 so as to spread in the direction perpendicular to the axis. For example, the positioning means protrudes from the inner peripheral surface of the peripheral wall portion 52 of the vial guide member 14. It may be constituted by a climbing protrusion that performs. Alternatively, an elastic film may be attached to the inner peripheral surface of the peripheral wall portion 52 of the vial guide member 14, and the mouth portion 92 of the vial 86 may be pressed and held on the elastic film.

  The slide movement preventing means may be any means that can prevent / allow slide movement before and after the positioning of the flange-shaped mouth portion 92 of the vial 86 with respect to the vial guide member 14 is completed. A separate engaging member that can be engaged is inserted through a through-hole provided in the main body 12 and engaged with the vial guide member 14, and the vial guide member 14 is moved inward in the axial direction until the positioning is completed. On the other hand, after the positioning is completed, the engaging member may be detached from the vial guide member 14 to allow the vial guide member 14 to move inward in the axial direction.

  Further, the number of the elastic bending pieces 58 is not limited to the four illustrated, and is not necessarily equal in the same direction, and may be shifted to avoid interference with other members. Good.

10: medicinal solution co-infusion apparatus, 12: body part, 14: vial guide member, 16: cylindrical body part, 18: partition wall, 20: vial mounting part, 22: liquid drug injection device mounting port, 24: puncture needle, 26: Tip portion, 28: Chemical solution passage, 40: Air passage, 48: Locking step surface, 58: Elastic deflection piece, 60: Base end portion, 62: Intermediate portion, 64: Tip portion, 68: Engagement protrusion, 70: Locking part, 72: Deformation restricting part, 74: Rib, 76: Rib receiving groove, 86: Vial, 92: Mouth

Claims (5)

A partition wall, a vial mounting part including a puncture needle protruding from one side of the partition wall and a cylindrical body part surrounding the puncture needle, and a liquid injection projecting from the other side of the partition wall A main body having an exhaust device mounting port;
A medicinal solution passage that penetrates through the inside of the puncture needle and has one end opening on the surface of the puncture needle and the other end opening on the liquid agent dispensing device mounting port;
An air passage penetrating through the inside of the puncture needle and having one end opened on the surface of the puncture needle and the other end opened on the outer peripheral surface of the main body,
The distal end portion of the puncture needle is fitted into the cylindrical body portion of the main body portion so as to be slidable in the axial direction and moves outward in the axial direction away from the partition wall of the main body portion. A cylindrical vial guide member that protrudes outward in the axial direction, and a drug solution co-infusion device comprising:
Positioning means for positioning and holding the flange-shaped mouth portion of the vial so as to spread in a direction perpendicular to the axis of the vial guide member;
Until the mouth of the vial is positioned and held by the vial guide member, the vial guide member is prevented from moving inward in the axial direction approaching the partition wall, and the vial is separated from the puncture needle. Holding slide movement preventing means,
After the mouth portion of the vial is positioned and held on the vial guide member, the movement prevention by the slide movement prevention means is released, and the vial guide member is allowed to move in the axially inward direction with respect to the vial. A medicinal solution co-infusion apparatus, wherein the puncture needle is punctured. The peripheral wall portion of the vial guide member is provided with elastic deflection pieces extending in the axial direction at a plurality of locations spaced apart from each other in the circumferential direction.
The elastic deflecting piece is connected and supported at the axially outward end of the vial guide member, the proximal end of which is spaced axially outward from the puncture needle, and is axially inward from the proximal end. From the intermediate portion extending in the axial direction, the distal end portion is a free end that can be bent and deformed in the axial direction, and an engaging projection that protrudes inward in the axial direction is formed on the inner peripheral surface of the free end. The medicinal-solution co-infusion device according to claim 1, wherein the positioning means is configured by being provided at a position. On the inner peripheral surface of the main body portion, there are provided locking stepped surfaces extending outward in the axial direction at a plurality of locations in the circumferential direction corresponding to the plurality of elastic bending pieces and at the same position in the axial direction. A locking portion that can be locked to the locking step surface is provided at the free end of the elastic bending piece,
Until the mouth portion of the vial is pushed into the inside of the vial guide member and positioned, the mouth portion of the vial is brought into contact with the engaging protrusion of the elastic deflecting piece so that the elastic deflecting piece is in the direction perpendicular to the axis. While being deformed outwardly, the locking portion is locked to the locking step surface and the slide movement preventing means is configured,
When the mouth portion of the vial is pushed further inward in the axial direction beyond the engagement protrusion, the bending deformation of the elastic bending piece outward in the axial direction is released, and the engagement protrusion has the flange-shaped vial. Elastically return to the position where the lower end surface of the mouth portion is held, and the mouth portion of the vial is positioned and supported by the engaging protrusion, and the engaging step surface of the body portion of the engaging portion of the elastic bending piece The medicinal-solution co-infusion device according to claim 2, wherein the locking of the vial guide member is released, and movement of the vial guide member in an axially inward direction is allowed.   An axially inner portion of the locking portion provided at the tip of the free end of the elastic bending piece further protrudes inward in the axial direction to form a deformation restricting portion, and the elastic bending piece is 4. The medicinal-solution co-infusion device according to claim 3, wherein an amount of bending deformation outward in the direction is regulated by contact between the deformation regulating portion and the inner peripheral surface of the main body portion. One of the inner peripheral surface of the cylindrical portion of the main body and the outer peripheral surface of the peripheral wall portion of the vial guide member is provided with a rib extending in the axial direction, while the other of the inner peripheral surface and the outer peripheral surface is provided. Is provided with a rib receiving groove for receiving the rib,
The medicinal-solution co-infusion device according to any one of claims 1 to 4, wherein the rib and the vial guide member are positioned in the circumferential direction by accommodating the rib in the rib-accommodating groove. .

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