JP2023183914A

JP2023183914A - Adapter and syringe with adapter

Info

Publication number: JP2023183914A
Application number: JP2022097721A
Authority: JP
Inventors: 等沖原; Hitoshi Okihara
Original assignee: Terumo Corp
Current assignee: Terumo Corp
Priority date: 2022-06-17
Filing date: 2022-06-17
Publication date: 2023-12-28

Abstract

To provide an adapter which eliminates possibilities for a user to forget to mix medicines and for the wrong administration to occur when adjusting an injection agent.SOLUTION: An adapter 14 connecting a syringe 12 and a vial includes: a needle member 38 which has a double-hook needle and is connectable to a mouth of the vial; a connection member 34 which has a holding member movably holding the needle member 38 in an axial direction and a connection part connected to a leading end of a barrel 16; and a lock member which contacts the connection part and blocks detachment of the connection part from the syringe 12. The lock member is connected to the needle member 38 by the vial being pushed into the needle member 38 and the needle member 38 approaching the connection part. The lock member is separated from the connection part together with the needle member 38 and the vial when the vial is detached from the syringe 12, and enables the connection member 34 to be detached from the syringe 12.SELECTED DRAWING: Figure 1

Description

本発明は、シリンジとバイアルとを接続するアダプタ及びアダプタ付きシリンジに関する。 The present invention relates to an adapter for connecting a syringe and a vial, and a syringe with an adapter.

従来より、２種類の薬剤（例えば、粉剤及び溶解液）を分離して保存し、使用直前にこれらの薬剤を混合して使用する注射剤が使用されている。このような注射剤は、例えば、一方の薬剤が粉剤としてバイアル容器に封入され、他方の薬剤が注射用水又は生理食塩水等の溶解液としてシリンジに封入されて提供される。 BACKGROUND ART Conventionally, injections have been used in which two types of drugs (for example, a powder and a solution) are stored separately and mixed immediately before use. Such injections are provided, for example, with one drug sealed in a vial container as a powder, and the other drug sealed in a syringe as a solution such as water for injection or physiological saline.

注射剤の調整は、粉剤入りのバイアルと溶解液を含んだシリンジとを連結器具（アダプタ）で接続して行われる。シリンジの溶解液は、バイアルの粉剤に導入され、注射剤の混合及び調整が行われる。調整した注射剤は、バイアルからシリンジに移送される。その後、シリンジからバイアルが取り外され、注射針がシリンジに取り付けられ、シリンジが注射剤の投与に使用される（例えば、特許文献１）。 Preparation of the injection is performed by connecting the vial containing the powder and the syringe containing the solution using a connecting device (adapter). The solution in the syringe is introduced into the powder in the vial, and the injection is mixed and prepared. The prepared injection is transferred from the vial to the syringe. Thereafter, the vial is removed from the syringe, the injection needle is attached to the syringe, and the syringe is used to administer the injection (for example, Patent Document 1).

特表２００７－５２５２６４号公報Special Publication No. 2007-525264

注射剤を調整する作業を行う際に、使用者（例えば、医療従事者又は患者）が薬剤の混合を忘れる場合がある。この場合には、使用者は、シリンジに封入されている溶解液（例えば、注射溶液や生理食塩水等）を調整済みの薬剤と誤認識し、混合操作を行わずにシリンジに注射針を取り付けて誤投与するおそれがある。 When preparing injections, users (e.g., health care workers or patients) may forget to mix the drugs. In this case, the user mistakenly recognizes the solution sealed in the syringe (e.g., injection solution, physiological saline, etc.) as a prepared drug, and attaches the needle to the syringe without performing the mixing operation. There is a risk of incorrect administration.

本発明は、上述した課題を解決することを目的とする。 The present invention aims to solve the above-mentioned problems.

以下の開示の一観点は、シリンジとバイアルとを接続するアダプタであって、両頭針を有し、前記バイアルの口部と接続可能な針部材と、前記針部材を軸線方向に移動可能に保持する保持部材と、前記シリンジのバレルの先端部に連結される連結部と、を有する接続部材と、前記連結部に当接して前記連結部の前記シリンジからの離脱を阻止するロック部材と、を備え、前記ロック部材は、前記針部材に前記バイアルが押し込まれて前記針部材が前記連結部に接近することにより前記針部材に連結され、前記ロック部材は、前記バイアルが前記シリンジから離間する際に前記針部材及び前記バイアルとともに前記連結部から離間して、前記接続部材の前記シリンジからの離脱を可能とする、アダプタにある。 One aspect of the following disclosure is an adapter for connecting a syringe and a vial, which includes a needle member having a double-ended needle and connectable to the opening of the vial, and holding the needle member movably in an axial direction. a connecting member having a holding member that is connected to the syringe; a connecting member that is connected to the distal end of the barrel of the syringe; and a locking member that abuts the connecting portion and prevents the connecting portion from detaching from the syringe. The locking member is coupled to the needle member when the vial is pushed into the needle member and the needle member approaches the coupling portion, and the locking member is coupled to the needle member when the vial is separated from the syringe. The adapter is separated from the connection part together with the needle member and the vial to enable the connection member to be removed from the syringe.

別の一観点は、上述観点のアダプタと、内部に医療用液体を収容したシリンジと、を備え、前記シリンジの前記先端部に前記アダプタが接続された、アダプタ付きシリンジにある。 Another aspect resides in a syringe with an adapter, which includes the adapter according to the above-mentioned aspect and a syringe containing a medical liquid therein, and the adapter is connected to the tip of the syringe.

上述観点のアダプタ及びアダプタ付きシリンジは、アダプタにバイアルを接続し、そのバイアルをシリンジから引き抜く操作が行われるまで、アダプタがシリンジから外れないため、薬剤の混合忘れを防止できる。 The adapter and the syringe with the adapter according to the above aspect can prevent forgetting to mix drugs because the adapter does not come off the syringe until the vial is connected to the adapter and the vial is pulled out from the syringe.

図１は、第１実施形態に係るアダプタ付きシリンジの斜視図である。FIG. 1 is a perspective view of a syringe with an adapter according to a first embodiment. 図２は、図１のアダプタ付きシリンジの分解状態での断面図である。FIG. 2 is a cross-sectional view of the syringe with adapter of FIG. 1 in an exploded state. 図３は、図１のアダプタとシリンジとの接続部分の拡大断面図である。FIG. 3 is an enlarged cross-sectional view of the connecting portion between the adapter and the syringe in FIG. 1. 図４Ａは、図１のシリンジ（キャップ付き）の先端部の拡大斜視図であり、図４Ｂは、図４Ａのシリンジの先端部の断面図である。4A is an enlarged perspective view of the distal end of the syringe (with a cap) of FIG. 1, and FIG. 4B is a cross-sectional view of the distal end of the syringe of FIG. 4A. 図５Ａは、図１のアダプタの接続部材を基端側から示す斜視図であり、図５Ｂは図５Ａの接続部材を先端側から示す斜視図である。5A is a perspective view showing the connecting member of the adapter of FIG. 1 from the proximal end side, and FIG. 5B is a perspective view showing the connecting member of FIG. 5A from the distal end side. 図６Ａは、図１のアダプタのロック部材を基端側から示す斜視図であり、図６Ｂは図６Ａのロック部材を先端側から示す斜視図である。6A is a perspective view showing the locking member of the adapter of FIG. 1 from the proximal end side, and FIG. 6B is a perspective view showing the locking member of FIG. 6A from the distal end side. 図７Ａは、図１のアダプタの針部材を基端側から示す斜視図であり、図７Ｂは図７Ａの針部材を先端側から示す斜視図である。7A is a perspective view of the needle member of the adapter in FIG. 1 from the proximal end, and FIG. 7B is a perspective view of the needle member of FIG. 7A from the distal end. 図８Ａは、シリンジと、ロック部材と、針部材との接続構造を示す透視図であり、図８Ｂは、図８ＡのＶＩＩＩＢ－ＶＩＩＩＢ線に沿った断面図である。FIG. 8A is a perspective view showing a connection structure between a syringe, a lock member, and a needle member, and FIG. 8B is a sectional view taken along line VIIIB-VIIIB in FIG. 8A. 図９Ａは、図１のアダプタ付きシリンジのアダプタにバイアルを挿入する直前の断面図であり、図９Ｂは図９Ａのバイアルにアダプタを接続した状態の断面図である。9A is a cross-sectional view of the syringe with an adapter shown in FIG. 1 just before the vial is inserted into the adapter, and FIG. 9B is a cross-sectional view of the vial shown in FIG. 9A with the adapter connected. 図１０は、針部材とロック部材とキャップとの連結構造を示す断面図である。FIG. 10 is a cross-sectional view showing the connection structure of the needle member, lock member, and cap. 図１１Ａは、バイアルをアダプタ付きシリンジの先端側に向けて引いた状態の断面図であり、図１１Ｂは、図１１Ａの状態におけるロック部材と、シリンジとの位置関係を示す透視図である。FIG. 11A is a sectional view of the vial pulled toward the distal end of the syringe with an adapter, and FIG. 11B is a perspective view showing the positional relationship between the locking member and the syringe in the state of FIG. 11A. 図１２は、アダプタをシリンジから離れる方向に移動させた状態の断面図である。FIG. 12 is a cross-sectional view of the adapter moved away from the syringe. 図１３は、第２実施形態に係るアダプタ付きシリンジの断面図である。FIG. 13 is a sectional view of a syringe with an adapter according to the second embodiment. 図１４Ａは、図１３のロック部材を先端側から示す斜視図であり、図１４Ｂは、図１３のＸＩＶＢ－ＸＩＶＢ線に沿った断面図である。14A is a perspective view showing the locking member of FIG. 13 from the distal end side, and FIG. 14B is a sectional view taken along the line XIVB-XIVB of FIG. 13. 図１５は、図１３のアダプタ付きシリンジにおいて、キャップをシリンジに残してアダプタを引き抜いた状態の断面図である。FIG. 15 is a sectional view of the syringe with adapter of FIG. 13 in a state where the adapter is pulled out leaving the cap on the syringe.

（第１実施形態）
図１に示すように、本実施形態に係るアダプタ付きシリンジ１０は、シリンジ１２とアダプタ１４とを有する。シリンジ１２は、薬剤である溶解液として、医療用液体を予め収容したプレフィルドシリンジである。医療用液体は、他の薬剤（例えば、粉剤）と混合して注射剤の調整に供される液体であり、例えば、生理食塩水や希釈用水等が挙げられる。シリンジ１２は、使用前に、アダプタ１４を介して薬剤を収容したバイアル９０（図９Ａ等参照）が接続される。シリンジ１２内の医療用液体は、バイアル９０に移された後、バイアル９０の内部の薬剤と混合される。バイアル９０の内部の注射薬は、シリンジ１２の内部に移されて投与に供される。 (First embodiment)
As shown in FIG. 1, the syringe with adapter 10 according to this embodiment includes a syringe 12 and an adapter 14. The syringe 12 is a prefilled syringe that contains a medical liquid in advance as a drug solution. The medical liquid is a liquid that is mixed with other drugs (for example, powder) to prepare an injection, and includes, for example, physiological saline, water for dilution, and the like. Before use, the syringe 12 is connected to a vial 90 containing a drug (see FIG. 9A, etc.) via the adapter 14. The medical liquid in the syringe 12 is transferred to the vial 90 and then mixed with the drug inside the vial 90. The injection drug inside the vial 90 is transferred to the inside of the syringe 12 for administration.

このようなアダプタ付きシリンジ１０において、アダプタ１４は、シリンジ１２のキャップ２４を覆うことで、バイアル９０の接続前の注射針の装着を阻止して、シリンジ１２の生理食塩水等の誤投与を防止する。アダプタ１４は、初期状態においてシリンジ１２から取り外しができないように、ロックされている。アダプタ１４は、バイアル９０をシリンジ１２と連通する位置にまで押し込んだ後にバイアル９０を引き抜くことでロックを解除し、シリンジ１２から取り外し可能となる。アダプタ付きシリンジ１０は、さらに以下の構成を有する。 In such a syringe with an adapter 10, the adapter 14 covers the cap 24 of the syringe 12 to prevent the injection needle from being attached before the vial 90 is connected, thereby preventing incorrect administration of physiological saline or the like from the syringe 12. do. The adapter 14 is locked in an initial state so that it cannot be removed from the syringe 12. The adapter 14 can be unlocked and removed from the syringe 12 by pushing the vial 90 into a position where it communicates with the syringe 12 and then pulling out the vial 90. The syringe with adapter 10 further has the following configuration.

図２に示すように、シリンジ１２は、バレル１６と、ガスケット２０と、プランジャ２２と、キャップ２４と、を有する。バレル１６は、円筒状の胴体部１７と、胴体部１７の先端から先端方向に突出したノズル１８と、ノズル１８を囲むロック筒１９とを有する。胴体部１７は、内部に軸線方向（シリンジ１２の中心軸線に沿う方向であり、先端側及び基端側の方向）に延在する空洞部１７ａを有する。ガスケット２０は、空洞部１７ａに軸線方向に摺動可能に配置される。ガスケット２０は、収容室２６の基端を液密及び気密に封止する。プランジャ２２は、ガスケット２０の基端に接続されている。プランジャ２２は、使用者の操作入力部であり、ガスケット２０を前進又は後退させる。 As shown in FIG. 2, the syringe 12 includes a barrel 16, a gasket 20, a plunger 22, and a cap 24. The barrel 16 has a cylindrical body part 17, a nozzle 18 protruding from the distal end of the body part 17 in a distal direction, and a lock cylinder 19 surrounding the nozzle 18. The body portion 17 has a hollow portion 17a that extends in the axial direction (the direction along the central axis of the syringe 12, and the direction toward the distal end and the proximal end). The gasket 20 is arranged in the cavity 17a so as to be slidable in the axial direction. The gasket 20 seals the base end of the storage chamber 26 in a liquid-tight and air-tight manner. Plunger 22 is connected to the proximal end of gasket 20. The plunger 22 is a user's operation input unit and moves the gasket 20 forward or backward.

ノズル１８及びロック筒１９は、バレル１６の先端部１６ａを構成する。ノズル１８は、内部に収容室２６に連通する流路１８ａを有する。ロック筒１９は、ノズル１８の外周部を囲む円筒状の部分である。ロック筒１９は、注射針を保持する部材である。ロック筒１９は、ロック筒１９の内周部に注射針を螺合するためのネジ構造を有してもよい。 The nozzle 18 and the lock tube 19 constitute a tip 16a of the barrel 16. The nozzle 18 has a flow path 18a inside thereof that communicates with the storage chamber 26. The lock tube 19 is a cylindrical portion surrounding the outer circumference of the nozzle 18. The lock barrel 19 is a member that holds the injection needle. The lock cylinder 19 may have a threaded structure for screwing an injection needle into the inner circumference of the lock cylinder 19.

図４Ａに示すように、ロック筒１９は、外周部１９ａに、アダプタ１４を保持するための連結溝２８を有する。連結溝２８は、第１連結溝２８ａと、第２連結溝２８ｂと、係合凹部２８ｃとを有する。第１連結溝２８ａは、ロック筒１９を肉薄にした軸線方向に延在する溝である。第２連結溝２８ｂは、ロック筒１９の周方向に短く延在する溝である。第２連結溝２８ｂの周方向の一端は、第１連結溝２８ａの軸線方向の途中で第１連結溝２８ａに接続する。係合凹部２８ｃは、第１連結溝２８ａの内部（底部）に位置する。係合凹部２８ｃは、第１連結溝２８ａよりも内方に凹んでいる。係合凹部２８ｃは、ロック部材３６をロック筒１９に仮固定する凹凸構造２９の一部を構成する。特に図示しないが、連結溝２８は、図４Ａのノズル１８の周方向の反対側にも形成されている。 As shown in FIG. 4A, the lock tube 19 has a connecting groove 28 for holding the adapter 14 in the outer peripheral portion 19a. The connection groove 28 has a first connection groove 28a, a second connection groove 28b, and an engagement recess 28c. The first connecting groove 28a is a groove extending in the axial direction of the lock cylinder 19 with a thin wall. The second connecting groove 28b is a short groove extending in the circumferential direction of the lock cylinder 19. One circumferential end of the second connecting groove 28b connects to the first connecting groove 28a midway in the axial direction of the first connecting groove 28a. The engagement recess 28c is located inside (bottom) of the first connection groove 28a. The engagement recess 28c is recessed more inward than the first connection groove 28a. The engagement recess 28c constitutes a part of the uneven structure 29 that temporarily fixes the lock member 36 to the lock cylinder 19. Although not particularly illustrated, the connecting groove 28 is also formed on the opposite side in the circumferential direction of the nozzle 18 in FIG. 4A.

図２及び図４Ｂに示すように、キャップ２４は、シリンジ１２の先端に装着され、シリンジ１２の収容室２６を封止する。キャップ２４は、栓体３０とケース３２とを有する。栓体３０は、ゴム等の弾性素材によって形成され、ノズル１８の先端及び外周に当接する封止部３０ａと、先端凹部３０ｂとを有する。先端凹部３０ｂは、先端側が凹んだ形状を有する。先端凹部３０ｂは、後述する基端針６６を収容する。先端凹部３０ｂと封止部３０ａとは、封止壁３０ｃにより隔てられている。 As shown in FIGS. 2 and 4B, the cap 24 is attached to the tip of the syringe 12 and seals the storage chamber 26 of the syringe 12. The cap 24 has a stopper 30 and a case 32. The plug body 30 is formed of an elastic material such as rubber, and has a sealing portion 30a that comes into contact with the tip and outer circumference of the nozzle 18, and a tip recessed portion 30b. The tip recess 30b has a concave shape on the tip side. The distal end recess 30b accommodates a proximal needle 66, which will be described later. The tip recess 30b and the sealing portion 30a are separated by a sealing wall 30c.

ケース３２は、筒状に形成される。ケース３２は、栓体３０よりも硬質な樹脂素材等によって形成されている。ケース３２は、内部に栓体３０を保持する。ケース３２は、アダプタ付きシリンジ１０の初期状態において、栓体３０の基端部とともに、ノズル１８とロック筒１９との間の隙間に挿入されている。キャップ２４は、主に摩擦力によってバレル１６の先端部１６ａに保持される。 Case 32 is formed into a cylindrical shape. The case 32 is made of a harder resin material than the plug body 30. The case 32 holds the plug 30 inside. In the initial state of the syringe with adapter 10, the case 32 is inserted into the gap between the nozzle 18 and the lock cylinder 19 together with the proximal end of the stopper 30. The cap 24 is held on the tip 16a of the barrel 16 mainly by frictional force.

図２に示すように、アダプタ１４は、接続部材３４と、ロック部材３６と、針部材３８と、を有する。アダプタ１４は、初期状態において、接続部材３４がシリンジ１２に接続されている。接続部材３４は、筒状形状を有する。接続部材３４は、連結部４０と、中間部４２と、保持筒４４（保持部材の一例）とを有する。 As shown in FIG. 2, the adapter 14 includes a connecting member 34, a locking member 36, and a needle member 38. In the adapter 14, the connecting member 34 is connected to the syringe 12 in an initial state. The connecting member 34 has a cylindrical shape. The connecting member 34 includes a connecting portion 40, an intermediate portion 42, and a holding tube 44 (an example of a holding member).

連結部４０は、接続部材３４の基端側に位置し、接続部材３４の中で最も小さな外径寸法を有する。連結部４０の内径寸法は、ロック筒１９の外径寸法よりも大きい。連結部４０の内周面４０ａは、ロック筒１９の外周部１９ａよりも外方に離間する。初期状態において、連結部４０の内周面４０ａとロック筒１９の外周部１９ａとの隙間は、ロック部材３６の挿入部３６ａを収容する。 The connecting portion 40 is located on the proximal end side of the connecting member 34 and has the smallest outer diameter dimension among the connecting members 34. The inner diameter of the connecting portion 40 is larger than the outer diameter of the lock cylinder 19. The inner circumferential surface 40a of the connecting portion 40 is spaced further outward than the outer circumferential portion 19a of the lock cylinder 19. In the initial state, the gap between the inner circumferential surface 40a of the connecting portion 40 and the outer circumferential portion 19a of the lock tube 19 accommodates the insertion portion 36a of the locking member 36.

図３に示すように、連結部４０は、初期状態において、ロック筒１９を周方向の全周に亘って囲むように装着される。連結部４０は、図５Ａに示すように、内周面４０ａから突出した連結突起４６を有する。連結突起４６は、周方向に短く延びた線状の突起であり、ロック筒１９の外周部１９ａに形成された第２連結溝２８ｂ（図４Ａ参照）に係合可能な寸法を有する。初期状態において、連結突起４６は、第２連結溝２８ｂに係合する。連結突起４６は、接続部材３４のシリンジ１２からの離脱を阻止する。連結突起４６は、連結部４０の周方向に１８０°の角度を開けて２つ配置されている。 As shown in FIG. 3, in the initial state, the connecting portion 40 is attached so as to surround the entire circumferential circumference of the lock tube 19. As shown in FIG. 5A, the connecting portion 40 has a connecting protrusion 46 protruding from the inner circumferential surface 40a. The connecting protrusion 46 is a linear protrusion that extends short in the circumferential direction, and has a size that allows it to engage with the second connecting groove 28b (see FIG. 4A) formed in the outer peripheral portion 19a of the lock cylinder 19. In the initial state, the connecting protrusion 46 engages with the second connecting groove 28b. The connecting protrusion 46 prevents the connecting member 34 from detaching from the syringe 12. Two connecting protrusions 46 are arranged at an angle of 180° in the circumferential direction of the connecting portion 40.

また、連結部４０は、内周面４０ａに軸線方向に延びる収容溝４８を有する。収容溝４８は、連結部４０の内周面４０ａから外周に向けて凹状に凹んだ形状を有する。収容溝４８は、連結突起４６の周方向に隣接して位置する。収容溝４８は、ロック部材３６のロック片３６ｄの外周側の一部を収容する。収容溝４８は、周方向に１８０°角度を開けて２つ配置されている。 Further, the connecting portion 40 has a housing groove 48 extending in the axial direction on the inner circumferential surface 40a. The housing groove 48 has a concave shape extending from the inner circumferential surface 40a of the connecting portion 40 toward the outer circumference. The accommodation groove 48 is located adjacent to the connecting protrusion 46 in the circumferential direction. The accommodation groove 48 accommodates a part of the outer peripheral side of the lock piece 36d of the lock member 36. Two housing grooves 48 are arranged at an angle of 180° in the circumferential direction.

中間部４２は、軸線方向において連結部４０と保持筒４４との間に位置し、段差部を介して連結部４０及び保持筒４４と一体的に繋がる。中間部４２は、連結部４０よりも大きな外径を有し、且つ保持筒４４よりも小さな外径を有する筒状の形状を有する。図３に示すように、初期状態において、中間部４２は、ロック部材３６の筒状の本体部３６ｃを軸線方向に摺動可能に収容する。中間部４２の内周面４２ａは、ロック部材３６の本体部３６ｃよりも僅かに大きな内径寸法を有する。なお、中間部４２の内周面４２ａは、本体部３６ｃから離間してもよい。 The intermediate portion 42 is located between the connecting portion 40 and the holding tube 44 in the axial direction, and is integrally connected to the connecting portion 40 and the holding tube 44 via the stepped portion. The intermediate portion 42 has a cylindrical shape that has a larger outer diameter than the connecting portion 40 and a smaller outer diameter than the holding cylinder 44 . As shown in FIG. 3, in the initial state, the intermediate portion 42 accommodates the cylindrical main body portion 36c of the locking member 36 so as to be slidable in the axial direction. The inner circumferential surface 42a of the intermediate portion 42 has an inner diameter slightly larger than the main body portion 36c of the locking member 36. Note that the inner circumferential surface 42a of the intermediate portion 42 may be spaced apart from the main body portion 36c.

図５Ａに示すように、中間部４２は、周方向に１８０°の間隔をあけて２つの膨出部５０を有する。膨出部５０は、中間部４２から外方に膨出した部分であり、軸線方向に延在する。図５Ｂに示すように、膨出部５０は、内部に軸線方向に延びる収容凹部５０ａを形成する。膨出部５０は、収容溝４８に対して周方向に９０°ずれた部分に位置する。図８Ａに示すように、初期状態において、中間部４２は、収容凹部５０ａの内部でロック部材３６の嵌合部５８を収容する。 As shown in FIG. 5A, the intermediate portion 42 has two bulges 50 spaced apart by 180 degrees in the circumferential direction. The bulging portion 50 is a portion that bulges outward from the intermediate portion 42 and extends in the axial direction. As shown in FIG. 5B, the bulge 50 forms an accommodating recess 50a that extends in the axial direction. The bulging portion 50 is located at a portion shifted by 90° in the circumferential direction with respect to the accommodation groove 48 . As shown in FIG. 8A, in the initial state, the intermediate portion 42 accommodates the fitting portion 58 of the locking member 36 inside the accommodation recess 50a.

図５Ａに示すように、保持筒４４は、接続部材３４の先端側に位置する。保持筒４４は、連結部４０及び中間部４２よりも大きな外径寸法を有する円筒形状を有する。図５Ｂに示すように、保持筒４４は、内部に収容空間４４ａを有する。収容空間４４ａは、針部材３８を軸線方向に移動可能に収容する。保持筒４４は、さらに案内部５２と、離脱防止爪５４とを有する。保持筒４４は、周方向に１８０°の角度間隔をあけて２つの案内部５２を有する。案内部５２は、内部に案内溝５２ａを形成する。各々の案内溝５２ａは、保持筒４４の内周面４４ｂに対して外周側に向けて凹んだ溝であり、軸線方向に延在する。案内溝５２ａの先端部は、保持筒４４の先端において開口する。案内溝５２ａは、収容溝４８と周方向の同じ位置に配置されている。図３に示すように、案内溝５２ａは、針部材３８の案内凸部５６を軸線方向に摺動可能に収容する。案内溝５２ａは、針部材３８の周方向の回転を阻止する。 As shown in FIG. 5A, the holding tube 44 is located on the distal end side of the connecting member 34. The holding tube 44 has a cylindrical shape with a larger outer diameter than the connecting portion 40 and the intermediate portion 42 . As shown in FIG. 5B, the holding cylinder 44 has a housing space 44a inside. The accommodation space 44a accommodates the needle member 38 so as to be movable in the axial direction. The holding cylinder 44 further includes a guide portion 52 and a detachment prevention claw 54. The holding cylinder 44 has two guide portions 52 spaced apart from each other by 180° in the circumferential direction. The guide portion 52 forms a guide groove 52a inside. Each guide groove 52a is a groove recessed toward the outer circumferential side with respect to the inner circumferential surface 44b of the holding cylinder 44, and extends in the axial direction. The leading end of the guide groove 52a opens at the leading end of the holding cylinder 44. The guide groove 52a is arranged at the same position in the circumferential direction as the accommodation groove 48. As shown in FIG. 3, the guide groove 52a accommodates the guide protrusion 56 of the needle member 38 so as to be slidable in the axial direction. The guide groove 52a prevents rotation of the needle member 38 in the circumferential direction.

図５Ｂに示すように、離脱防止爪５４は、保持筒４４の内周面４４ｂから内方に突出する。離脱防止爪５４は、保持筒４４の先端の開口部４４ｃの近傍に位置する。離脱防止爪５４は、針部材３８の外周爪５７（図７Ａ参照）と当接可能な周方向の位置に配置される。特に限定されるものではないが、図示の例では、離脱防止爪５４は、各々の案内溝５２ａに隣接して２つ、合計４個設けられている。離脱防止爪５４は、針部材３８の外周爪５７に当接することで、針部材３８の保持筒４４からの離脱を阻止する。 As shown in FIG. 5B, the detachment prevention claw 54 projects inward from the inner circumferential surface 44b of the holding cylinder 44. As shown in FIG. The detachment prevention claw 54 is located near the opening 44c at the tip of the holding cylinder 44. The detachment prevention claw 54 is arranged at a position in the circumferential direction where it can come into contact with the outer peripheral claw 57 of the needle member 38 (see FIG. 7A). Although not particularly limited, in the illustrated example, two detachment prevention claws 54 are provided adjacent to each guide groove 52a, a total of four. The detachment prevention claw 54 prevents the needle member 38 from detaching from the holding cylinder 44 by coming into contact with the outer peripheral claw 57 of the needle member 38 .

図２に示すように、アダプタ１４のロック部材３６は、接続部材３４と針部材３８との間に配置される。図６Ａに示すように、ロック部材３６は、基端側に位置する挿入部３６ａと、先端側に位置する本体部３６ｃとを有する。挿入部３６ａは、初期状態において、バレル１６の先端部１６ａ（ロック筒１９）の外周と、接続部材３４との隙間に挿入される部分である。挿入部３６ａは、さらに円周壁３６ｂと、ロック片３６ｄと、仮止部３６ｅとを有する。円周壁３６ｂは、本体部３６ｃの基端壁３６ｃ１から基端側に向けて軸方向に短く延び出た円筒形状の部分である。円周壁３６ｂは、初期状態において、図３に示すように、ロック筒１９よりも先端側に位置し、キャップ２４と接続部材３４との隙間に配置される。 As shown in FIG. 2, locking member 36 of adapter 14 is disposed between connecting member 34 and needle member 38. As shown in FIG. As shown in FIG. 6A, the locking member 36 has an insertion portion 36a located on the proximal end side and a main body portion 36c located on the distal end side. The insertion portion 36a is a portion inserted into a gap between the outer periphery of the tip portion 16a (lock cylinder 19) of the barrel 16 and the connecting member 34 in an initial state. The insertion portion 36a further includes a circumferential wall 36b, a locking piece 36d, and a temporary fixing portion 36e. The circumferential wall 36b is a cylindrical portion that extends short in the axial direction from the base end wall 36c1 of the main body portion 36c toward the base end side. In the initial state, as shown in FIG. 3, the circumferential wall 36b is located closer to the tip than the lock cylinder 19, and is disposed in the gap between the cap 24 and the connecting member 34.

図６Ａに示すように、ロック片３６ｄは、円周壁３６ｂの基端から軸線方向に延び出た板状の部分である。ロック片３６ｄは、周方向に１８０°離れて２つ配置されている。ロック片３６ｄは、円周壁３６ｂと同じ半径の円周に沿って湾曲する。ロック片３６ｄの周方向の寸法は、図４Ａに示すロック筒１９の第１連結溝２８ａの周方向の寸法よりも僅かに小さい。図８Ａに示すように、初期状態において、ロック片３６ｄは、内周側の一部がロック筒１９の第１連結溝２８ａに収容される。ロック片３６ｄは、第２連結溝２８ｂに収容された連結突起４６の周方向の変位を阻止し、連結突起４６の第２連結溝２８ｂからの離脱を阻止するロック機構を構成する。 As shown in FIG. 6A, the lock piece 36d is a plate-shaped portion extending in the axial direction from the base end of the circumferential wall 36b. Two lock pieces 36d are arranged 180 degrees apart in the circumferential direction. The lock piece 36d is curved along the circumference having the same radius as the circumferential wall 36b. The circumferential dimension of the lock piece 36d is slightly smaller than the circumferential dimension of the first connecting groove 28a of the lock tube 19 shown in FIG. 4A. As shown in FIG. 8A, in the initial state, a portion of the inner peripheral side of the lock piece 36d is accommodated in the first connecting groove 28a of the lock cylinder 19. The lock piece 36d constitutes a locking mechanism that prevents circumferential displacement of the connecting protrusion 46 accommodated in the second connecting groove 28b and prevents the connecting protrusion 46 from separating from the second connecting groove 28b.

図６Ａに示すように、仮止部３６ｅは、ロック片３６ｄの内周面から内方に向けて突出する。仮止部３６ｅは、図４Ａに示すロック筒１９の係合凹部２８ｃに係合可能な部位に位置する。初期状態において、図８Ｂに示すように、仮止部３６ｅは、係合凹部２８ｃに係合する。仮止部３６ｅは、係合凹部２８ｃと係合することで、摩擦抵抗を増加させ、ロック部材３６のロック筒１９からの引き抜けに対して、適度な抵抗力を発生させる。仮止部３６ｅは所定以上の力でロック部材３６を先端側に引っ張ると、係合凹部２８ｃから離脱してロック片３６ｄの第１連結溝２８ａからの離脱を許容する。仮止部３６ｅ及び係合凹部２８ｃは、ロック部材３６をシリンジ１２に仮固定する凹凸構造２９を構成する。 As shown in FIG. 6A, the temporary fixing portion 36e protrudes inward from the inner peripheral surface of the locking piece 36d. The temporary fixing portion 36e is located at a portion that can be engaged with the engagement recess 28c of the lock tube 19 shown in FIG. 4A. In the initial state, as shown in FIG. 8B, the temporary fixing portion 36e engages with the engagement recess 28c. The temporary fixing portion 36e increases frictional resistance by engaging with the engagement recess 28c, and generates an appropriate resistance force against the lock member 36 being pulled out from the lock tube 19. When the locking member 36 is pulled toward the distal end side with a force greater than a predetermined value, the temporary fixing portion 36e separates from the engagement recess 28c and allows the locking piece 36d to separate from the first connecting groove 28a. The temporary fixing portion 36e and the engagement recess 28c constitute an uneven structure 29 that temporarily fixes the locking member 36 to the syringe 12.

図６Ａに示すように、本体部３６ｃは、挿入部３６ａの先端側に位置する円筒状の部分である。本体部３６ｃは、挿入部３６ａよりも大きな外径寸法を有する。本体部３６ｃは、基端壁３６ｃ１を介して挿入部３６ａと接続されている。本体部３６ｃは、内部に空洞部３６ｆを有する。空洞部３６ｆの基端は基端壁３６ｃ１によって部分的に塞がれ、空洞部３６ｆの先端は開口する。空洞部３６ｆは、針部材３８の基端筒６８（図７Ａ参照）を収容可能である。本体部３６ｃは、針部材３８に連結される嵌合部５８を有する。嵌合部５８は、周方向に１８０°離れて２つ設けられている。各々の嵌合部５８は、本体部３６ｃよりも外方に僅かに膨出する。嵌合部５８は、ロック片３６ｄに対して周方向に９０°離れて位置する。嵌合部５８は、先端側が軸線方向に延びる一対の分離溝５８ａを介して本体部３６ｃから分離されている。分離溝５８ａは、本体部３６ｃの先端部から基端壁３６ｃ１にまで延在する。そのため、嵌合部５８は、円周壁３６ｂを介して本体部３６ｃに繋がっている。このような分離溝５８ａは、嵌合部５８の径方向への弾性変形を容易にする。嵌合部５８は、接続部材３４の収容凹部５０ａ（図５Ｂ参照）に挿入される。嵌合部５８及び収容凹部５０ａは、ロック部材３６の周方向の回転を規制し、ロック部材３６の軸線方向への移動を許容する。 As shown in FIG. 6A, the main body portion 36c is a cylindrical portion located on the distal end side of the insertion portion 36a. The main body portion 36c has a larger outer diameter than the insertion portion 36a. The main body portion 36c is connected to the insertion portion 36a via the proximal wall 36c1. The main body portion 36c has a hollow portion 36f inside. The proximal end of the cavity 36f is partially closed by the proximal wall 36c1, and the distal end of the cavity 36f is open. The hollow portion 36f can accommodate the proximal tube 68 (see FIG. 7A) of the needle member 38. The main body portion 36c has a fitting portion 58 connected to the needle member 38. Two fitting portions 58 are provided 180° apart in the circumferential direction. Each fitting portion 58 slightly bulges outward from the main body portion 36c. The fitting portion 58 is located 90° apart from the lock piece 36d in the circumferential direction. The fitting portion 58 is separated from the main body portion 36c via a pair of separation grooves 58a that extend in the axial direction on the distal end side. The separation groove 58a extends from the distal end of the main body portion 36c to the base end wall 36c1. Therefore, the fitting portion 58 is connected to the main body portion 36c via the circumferential wall 36b. Such a separation groove 58a facilitates elastic deformation of the fitting portion 58 in the radial direction. The fitting portion 58 is inserted into the accommodation recess 50a (see FIG. 5B) of the connection member 34. The fitting portion 58 and the housing recess 50a restrict rotation of the lock member 36 in the circumferential direction and allow movement of the lock member 36 in the axial direction.

嵌合部５８は、さらに、窓部５８ｂと、嵌合突起５８ｃとを有する、窓部５８ｂは、嵌合部５８を厚さ方向（径方向）に貫通する矩形状の孔である。窓部５８ｂには、針部材３８を基端側に向けて押し込んだ際に、針部材３８の第１爪部材６０が内方から入り込む。嵌合突起５８ｃは、窓部５８ｂの先端側に隣接して形成される。嵌合突起５８ｃは、基端部に軸線方向に対して垂直に切り立った端面５８ｃ１を有する。端面５８ｃ１は、針部材３８の第１爪部材６０（図７Ａ参照）と引っ掛かることで、針部材３８とロック部材３６とを強固に連結する。嵌合部５８と第１爪部材６０との接続強度は、ロック片３６ｄと第１連結溝２８ａとの摩擦抵抗よりも大きい。以上のようなロック部材３６のロック片３６ｄは、図３に示すように、初期状態において接続部材３４の内周面と、バレル１６の先端部１６ａ（ロック筒１９）の外周面との間に挿入される。ロック片３６ｄは、連結突起４６の周方向から当接することで、接続部材３４の回動を阻止する。 The fitting portion 58 further includes a window portion 58b and a fitting protrusion 58c. The window portion 58b is a rectangular hole passing through the fitting portion 58 in the thickness direction (radial direction). When the needle member 38 is pushed toward the proximal end, the first claw member 60 of the needle member 38 enters the window portion 58b from inside. The fitting protrusion 58c is formed adjacent to the distal end side of the window portion 58b. The fitting protrusion 58c has an end face 58c1 at its base end that is perpendicular to the axial direction. The end surface 58c1 firmly connects the needle member 38 and the locking member 36 by engaging with the first claw member 60 (see FIG. 7A) of the needle member 38. The connection strength between the fitting portion 58 and the first claw member 60 is greater than the frictional resistance between the lock piece 36d and the first connection groove 28a. As shown in FIG. 3, the locking piece 36d of the locking member 36 as described above is located between the inner circumferential surface of the connecting member 34 and the outer circumferential surface of the tip 16a (lock tube 19) of the barrel 16 in the initial state. inserted. The locking piece 36d prevents the connecting member 34 from rotating by coming into contact with the connecting protrusion 46 from the circumferential direction.

図２に示すように、アダプタ１４の針部材３８は、ロック部材３６の先端側に位置する。図３に示すように、針部材３８は、接続部材３４の保持筒４４に、軸線方向に移動可能に収容される。針部材３８は、図７Ａ及び図７Ｂに示すように、キャップ接続部６２と、両頭針６３と、バイアル接続部６４と、を有する。キャップ接続部６２は、基端側に位置し、キャップ２４に接続される部分である。バイアル接続部６４は、キャップ接続部６２の先端側に位置し、バイアル９０が接続される部分である。両頭針６３は、基端針６６と先端針７０とにより構成される。 As shown in FIG. 2, the needle member 38 of the adapter 14 is located on the distal end side of the locking member 36. As shown in FIG. 3, the needle member 38 is housed in the holding cylinder 44 of the connecting member 34 so as to be movable in the axial direction. The needle member 38 has a cap connection part 62, a double-ended needle 63, and a vial connection part 64, as shown in FIGS. 7A and 7B. The cap connecting portion 62 is a portion located on the proximal end side and connected to the cap 24. The vial connecting portion 64 is located on the distal end side of the cap connecting portion 62 and is a portion to which the vial 90 is connected. The double-ended needle 63 includes a proximal needle 66 and a distal needle 70.

キャップ接続部６２は、基端針６６と、基端筒６８とを有する。基端針６６は、中心軸線に沿って軸線方向に基端側に向けて突出する。基端針６６の端部には、キャップ２４の栓体３０を貫通可能な鋭利な針先６６ａが形成される。基端針６６の内部には流路６６ｂが形成される。流路６６ｂは、先端針７０の流路７０ｂに連通する。基端筒６８は、基端針６６の周囲を囲むようにして基端側に向けて突出した円筒状の壁よりなる。基端筒６８は、キャップ２４のケース３２の先端部を収容可能な内径寸法を有する。基端筒６８は、内周部６８ａに複数の第２爪部材７１を有する。第２爪部材７１は、基端から先端側に向けて徐々に中心軸線に向けて接近するように傾斜して突出した板状部材である。第２爪部材７１の先端７１ａは、針部材３８が、キャップ２４に穿刺されると、ケース３２の先端のフランジ状のリブ３２ａに係合し、針部材３８とキャップ２４とを離脱不能に接続する。 The cap connection portion 62 has a proximal needle 66 and a proximal tube 68. The proximal needle 66 protrudes toward the proximal end in the axial direction along the central axis. A sharp needle tip 66a that can penetrate the plug 30 of the cap 24 is formed at the end of the proximal needle 66. A flow path 66b is formed inside the proximal needle 66. The flow path 66b communicates with the flow path 70b of the tip needle 70. The proximal tube 68 is made of a cylindrical wall that surrounds the proximal needle 66 and protrudes toward the proximal end. The proximal tube 68 has an inner diameter that can accommodate the distal end of the case 32 of the cap 24 . The proximal tube 68 has a plurality of second claw members 71 on the inner peripheral portion 68a. The second claw member 71 is a plate-like member that projects in an inclined manner from the base end toward the distal end side so as to gradually approach the central axis. When the needle member 38 punctures the cap 24, the tip 71a of the second claw member 71 engages with the flange-shaped rib 32a at the tip of the case 32, irremovably connecting the needle member 38 and the cap 24. do.

また、基端筒６８は、外周部に第１爪部材６０を有する。第１爪部材６０は、基端筒６８の外周部から外方に突出する。第１爪部材６０は、周方向に線状に延びる。第１爪部材６０は、先端に軸線方向に対して垂直に切り立った先端面を有する。第１爪部材６０は、針部材３８がキャップ２４に穿刺されると、嵌合部５８の窓部５８ｂ（図６Ａ参照）に挿入され、嵌合突起５８ｃと嵌合する。第１爪部材６０は、嵌合部５８と嵌合することで、ロック部材３６と針部材３８とを強固に接続する。 Further, the base end tube 68 has a first claw member 60 on the outer peripheral portion. The first claw member 60 projects outward from the outer circumferential portion of the proximal tube 68 . The first claw member 60 extends linearly in the circumferential direction. The first claw member 60 has a distal end surface that is perpendicular to the axial direction. When the needle member 38 is inserted into the cap 24, the first claw member 60 is inserted into the window portion 58b (see FIG. 6A) of the fitting portion 58, and is fitted with the fitting protrusion 58c. The first claw member 60 firmly connects the locking member 36 and the needle member 38 by fitting into the fitting portion 58 .

針部材３８のバイアル接続部６４は、先端針７０と、先端筒７２と、を有する。先端針７０は、図７Ｂに示すように、中心軸線に沿って先端に向けて突出する針部である。先端針７０は、バイアル９０の栓体９４（図９Ａ参照）を貫通可能な長さを有し、先端に鋭利な針先７０ａを有する。先端針７０は、内部に軸線方向に貫通する流路７０ｂを有する。流路７０ｂは、基端針６６の流路６６ｂに連通する。 The vial connecting portion 64 of the needle member 38 has a tip needle 70 and a tip tube 72. The tip needle 70 is a needle portion that protrudes toward the tip along the central axis, as shown in FIG. 7B. The tip needle 70 has a length capable of penetrating the stopper 94 (see FIG. 9A) of the vial 90, and has a sharp needle tip 70a at the tip. The tip needle 70 has a flow path 70b that penetrates therein in the axial direction. The flow path 70b communicates with the flow path 66b of the proximal needle 66.

先端筒７２は、先端針７０の外方を囲む円筒状の壁を有する。先端筒７２は、基端筒６８よりも大きな外径の円筒形状を有する。先端筒７２は、基端壁７２ａを介して基端筒６８と接続されている。先端筒７２は、内側にバイアル９０の口部９２を収容する接続凹部７４を有する。接続凹部７４は、図７Ａ及び図７Ｂに示すように基端側が先端筒７２の基端壁７２ａによって閉塞されてよいが、接続凹部７４の基端側が閉塞されない態様で先端筒７２と基端筒６８とを接続してもよい。接続凹部７４は、先端側が開口する。先端筒７２は、バイアル９０の口部９２（図９Ａ参照）を保持する保持片７６を有する。保持片７６は、バイアル９０の口部９２に嵌合する突起７６ａを有する。保持片７６は、突起７６ａの周方向の両側部に一対の分離溝７６ｂを有する。分離溝７６ｂは、保持片７６の径方向に弾性変形しやすくすることで、針部材３８への口部９２の接続を容易にする。 The tip tube 72 has a cylindrical wall that surrounds the outside of the tip needle 70. The distal tube 72 has a cylindrical shape with a larger outer diameter than the proximal tube 68. The distal tube 72 is connected to the proximal tube 68 via the proximal wall 72a. The tip tube 72 has a connecting recess 74 that accommodates the opening 92 of the vial 90 inside. As shown in FIGS. 7A and 7B, the connection recess 74 may be closed at its proximal end by the proximal wall 72a of the distal tube 72, but the connection recess 74 may be connected to the distal tube 72 in such a manner that the proximal end of the connection recess 74 is not closed. 68 may be connected. The connection recess 74 is open on the tip side. The tip tube 72 has a holding piece 76 that holds the opening 92 of the vial 90 (see FIG. 9A). The holding piece 76 has a protrusion 76a that fits into the opening 92 of the vial 90. The holding piece 76 has a pair of separation grooves 76b on both sides of the protrusion 76a in the circumferential direction. The separation groove 76b facilitates elastic deformation of the holding piece 76 in the radial direction, thereby facilitating connection of the mouth portion 92 to the needle member 38.

先端筒７２は、外周部に案内凸部５６と、外周爪５７と、を有する。案内凸部５６は、先端筒７２の外周部に２つ設けられる。各々の案内凸部５６は、第１爪部材６０の中心に対して周方向に９０°離れた位置に形成される。案内凸部５６は、先端筒７２から外周に向けて突出した板状の突起である。案内凸部５６は、軸線方向に長く延びる。案内凸部５６は、接続部材３４の案内溝５２ａに挿入されて、針部材３８の接続部材３４に対する周方向の回転を規制する。外周爪５７は、接続部材３４の離脱防止爪５４に係合する。外周爪５７は、案内凸部５６に隣接して２つ配置されている。 The tip tube 72 has a guide convex portion 56 and an outer circumference claw 57 on the outer circumference. Two guide protrusions 56 are provided on the outer circumference of the tip tube 72. Each guide protrusion 56 is formed at a position 90° apart from the center of the first claw member 60 in the circumferential direction. The guide convex portion 56 is a plate-shaped protrusion that protrudes from the tip tube 72 toward the outer periphery. The guide protrusion 56 extends long in the axial direction. The guide convex portion 56 is inserted into the guide groove 52a of the connecting member 34 and restricts rotation of the needle member 38 with respect to the connecting member 34 in the circumferential direction. The outer circumferential claw 57 engages with the detachment prevention claw 54 of the connecting member 34 . Two outer circumferential claws 57 are arranged adjacent to the guide protrusion 56.

図３に示すように、アダプタ１４は、初期状態において、接続部材３４がシリンジ１２に接続される。ロック部材３６及び針部材３８は、接続部材３４の内部に収容されている。ロック部材３６の挿入部３６ａは、接続部材３４とバレル１６の先端部１６ａ（ロック筒１９）の外周部との間に挿入される。図８Ａに示すように、ロック部材３６のロック片３６ｄは、第１連結溝２８ａに挿入されて、接続部材３４の連結突起４６に、周方向から当接する。ロック片３６ｄは、連結突起４６の周方向の回動を阻止することで、連結突起４６の第２連結溝２８ｂからの離脱を阻止し、接続部材３４がシリンジ１２に連結された状態に保持する。図８Ｂに示すように、ロック部材３６は、仮止部３６ｅを通じてロック筒１９に仮固定される。ロック部材３６は、バイアル９０の接続とそれに続く引き抜き動作が行われるまで、仮固定された状態に保たれ、接続部材３４とシリンジ１２との連結状態を保持する。 As shown in FIG. 3, the connecting member 34 of the adapter 14 is connected to the syringe 12 in the initial state. The locking member 36 and the needle member 38 are housed inside the connecting member 34. The insertion portion 36a of the lock member 36 is inserted between the connection member 34 and the outer circumference of the tip portion 16a (lock tube 19) of the barrel 16. As shown in FIG. 8A, the lock piece 36d of the lock member 36 is inserted into the first connection groove 28a and contacts the connection protrusion 46 of the connection member 34 from the circumferential direction. The lock piece 36d prevents the connecting protrusion 46 from rotating in the circumferential direction, thereby preventing the connecting protrusion 46 from separating from the second connecting groove 28b, and holds the connecting member 34 connected to the syringe 12. . As shown in FIG. 8B, the lock member 36 is temporarily fixed to the lock cylinder 19 through the temporary fixing part 36e. The locking member 36 is maintained in a temporarily fixed state until the vial 90 is connected and the subsequent withdrawal operation is performed, and maintains the connected state between the connecting member 34 and the syringe 12.

図３に示すように、初期状態において、針部材３８は、ロック部材３６の先端側に位置した状態で、保持筒４４の内部に収容される。基端針６６の一部は、栓体３０の先端凹部３０ｂに配置される。 As shown in FIG. 3, in the initial state, the needle member 38 is housed inside the holding tube 44 while being located on the distal end side of the locking member 36. A portion of the proximal needle 66 is disposed in the distal end recess 30b of the plug body 30.

アダプタ付きシリンジ１０は、以下のように使用される。 The syringe with adapter 10 is used as follows.

アダプタ付きシリンジ１０は、初期状態において、アダプタ１４がシリンジ１２から離脱不能に連結されている。したがって、アダプタ付きシリンジ１０は、使用者が注射液の調製を行う前に、シリンジ１２からアダプタ１４を取り外して注射針を付けるといった、誤使用の発生を防止する。 In the syringe with adapter 10, the adapter 14 is irremovably connected to the syringe 12 in an initial state. Therefore, the syringe with adapter 10 prevents the user from using it incorrectly, such as when the user removes the adapter 14 from the syringe 12 and attaches the injection needle before preparing the injection solution.

図９Ａに示すように、アダプタ付きシリンジ１０は、アダプタ１４にバイアル９０を挿入して使用される。バイアル９０は、栓体９４を有する口部９２が針部材３８の先端筒７２に挿入される。バイアル９０の内部には、例えば粉状又は液体状の薬剤が封入されている。 As shown in FIG. 9A, the syringe with adapter 10 is used by inserting a vial 90 into the adapter 14. The vial 90 has a mouth portion 92 having a stopper 94 inserted into the tip tube 72 of the needle member 38 . For example, a powdered or liquid drug is sealed inside the vial 90.

図９Ｂに示すように、バイアル９０がシリンジ１２に向けて押し込まれると、針部材３８の基端針６６がキャップ２４の栓体３０を貫通し、針部材３８の先端針７０がバイアル９０の栓体９４を貫通する。シリンジ１２の収容室２６と、バイアル９０の内部とは、針部材３８の流路６６ｂ、７０ｂを介して連通する。バイアル９０がシリンジ１２に接続されると、針部材３８が基端側に変位する。図１０に示すように、針部材３８の基端筒６８は、ロック部材３６の本体部３６ｃと、キャップ２４との隙間に挿入される。その結果、針部材３８の第１爪部材６０が窓部５８ｂに入り込み、第１爪部材６０がロック部材３６の嵌合部５８に嵌合する。以後、ロック部材３６は針部材３８と一体的に変位する。また、針部材３８の第２爪部材７１は、キャップ２４のリブ３２ａに嵌合する。その結果、針部材３８とキャップ２４が強固に接続され、キャップ２４は、針部材３８と一体的に変位する。 As shown in FIG. 9B, when the vial 90 is pushed toward the syringe 12, the proximal needle 66 of the needle member 38 penetrates the stopper 30 of the cap 24, and the distal needle 70 of the needle member 38 penetrates the stopper of the vial 90. It penetrates the body 94. The storage chamber 26 of the syringe 12 and the inside of the vial 90 communicate with each other via flow paths 66b and 70b of the needle member 38. When the vial 90 is connected to the syringe 12, the needle member 38 is displaced proximally. As shown in FIG. 10, the proximal tube 68 of the needle member 38 is inserted into the gap between the main body portion 36c of the locking member 36 and the cap 24. As shown in FIG. As a result, the first claw member 60 of the needle member 38 enters the window portion 58b, and the first claw member 60 fits into the fitting portion 58 of the lock member 36. Thereafter, the lock member 36 is displaced integrally with the needle member 38. Further, the second claw member 71 of the needle member 38 fits into the rib 32a of the cap 24. As a result, the needle member 38 and the cap 24 are firmly connected, and the cap 24 is displaced integrally with the needle member 38.

その後、プランジャ２２の操作により、収容室２６の医療用液体がバイアル９０の内部に導入される。そして、バイアル９０の内部の薬剤と医療用液体とが混合されて、注射薬の調整が行われる。バイアル９０で調整された、注射薬はプランジャ２２の操作により、シリンジ１２の収容室２６に導入される。 Thereafter, by operating the plunger 22, the medical liquid in the storage chamber 26 is introduced into the vial 90. Then, the medicine and medical liquid inside the vial 90 are mixed to prepare an injection. The injection drug prepared in the vial 90 is introduced into the storage chamber 26 of the syringe 12 by operating the plunger 22.

次に、アダプタ１４をシリンジ１２から取り外す操作が行われる。この操作は、図１１Ａに示すように、バイアル９０をシリンジ１２から離れる方向（先端側）にむけて引き抜く操作を含む。バイアル９０を引き抜くと、針部材３８、キャップ２４及びロック部材３６がバイアル９０とともに、先端側に向けて変位する。ロック部材３６は、針部材３８とともに変位し、ロック片３６ｄは第１連結溝２８ａから引き抜かれる。これにより、接続部材３４は、周方向に回転可能となる。 Next, an operation is performed to remove the adapter 14 from the syringe 12. This operation includes an operation of pulling out the vial 90 in a direction away from the syringe 12 (toward the tip side), as shown in FIG. 11A. When the vial 90 is pulled out, the needle member 38, the cap 24, and the lock member 36 are displaced toward the distal end side together with the vial 90. The lock member 36 is displaced together with the needle member 38, and the lock piece 36d is pulled out from the first connecting groove 28a. Thereby, the connecting member 34 becomes rotatable in the circumferential direction.

その後、使用者の操作によって、図１１Ｂに示すように、接続部材３４が回転されると、連結突起４６が第２連結溝２８ｂから第１連結溝２８ａへと移動するため、接続部材３４をシリンジ１２から先端側に引き抜くことができる。以上の操作により、図１２に示すように、アダプタ１４がシリンジ１２から引き抜かれる。その後、シリンジ１２のノズル１８に注射針を装着して、シリンジ１２が注射薬の投与に利用される。 Thereafter, when the connecting member 34 is rotated by the user's operation as shown in FIG. 11B, the connecting protrusion 46 moves from the second connecting groove 28b to the first connecting groove 28a. 12 and can be pulled out toward the distal end. By the above operation, the adapter 14 is pulled out from the syringe 12, as shown in FIG. Thereafter, a needle is attached to the nozzle 18 of the syringe 12, and the syringe 12 is used for administering an injection.

以上のように、本実施形態のアダプタ付きシリンジ１０は、バイアル９０を接続しない限り、アダプタ１４をシリンジ１２から取り外せない構造となっている。そのため、アダプタ付きシリンジ１０は、シリンジ１２の未調整の注射液の誤投与を防止できる。 As described above, the syringe with adapter 10 of this embodiment has a structure in which the adapter 14 cannot be removed from the syringe 12 unless the vial 90 is connected. Therefore, the syringe with adapter 10 can prevent incorrect administration of unadjusted injection liquid from the syringe 12.

（第２実施形態）
図１３に示すように、本実施形態のアダプタ付きシリンジ１０Ａは、シリンジ１２と、アダプタ１４Ａとを有する。アダプタ１４Ａは、ロック部材３６Ａ及び針部材３８Ａにおいて、第１実施形態のアダプタ１４と異なっている。なお、アダプタ付きシリンジ１０Ａの構成において、アダプタ付きシリンジ１０の対応する構成と同様の部材には、同一の符号を付してその詳細な説明は省略する。 (Second embodiment)
As shown in FIG. 13, the syringe with adapter 10A of this embodiment includes a syringe 12 and an adapter 14A. The adapter 14A differs from the adapter 14 of the first embodiment in a lock member 36A and a needle member 38A. In the configuration of the syringe with adapter 10A, the same members as those in the corresponding configuration of the syringe with adapter 10 are designated by the same reference numerals, and detailed description thereof will be omitted.

図１４Ａに示すように、ロック部材３６Ａは、本体部３６ｃの外周部に仮止突起７８を有する。仮止突起７８は、図６Ａの仮止部３６ｅの代わりに設けられる。図１４Ｂに示すように、仮止突起７８は、接続部材３４に当接することで、ロック部材３６Ａを接続部材３４に仮固定する。 As shown in FIG. 14A, the locking member 36A has a temporary fixing protrusion 78 on the outer periphery of the main body portion 36c. The temporary fixing protrusion 78 is provided in place of the temporary fixing part 36e in FIG. 6A. As shown in FIG. 14B, the temporary fixing protrusion 78 temporarily fixes the locking member 36A to the connecting member 34 by coming into contact with the connecting member 34.

図１３に示すように、針部材３８Ａは、基端筒６８の内周側に第２爪部材７１（図７Ａ参照）を有さない。本実施形態の、針部材３８Ａは、針部材３８Ａをシリンジ１２に向けて押し込んだ場合であっても、キャップ２４に連結されない。なお、針部材３８Ａは、シリンジ１２に向けて押し込まれると、ロック部材３６Ａに接続される。 As shown in FIG. 13, the needle member 38A does not have the second claw member 71 (see FIG. 7A) on the inner peripheral side of the proximal tube 68. In this embodiment, the needle member 38A is not connected to the cap 24 even when the needle member 38A is pushed toward the syringe 12. Note that when the needle member 38A is pushed toward the syringe 12, it is connected to the lock member 36A.

図１５に示すように、本実施形態のアダプタ付きシリンジ１０Ａは、バイアル９０をシリンジ１２に接続させた後に、図９Ａ～図１２を参照しつつ説明した操作により、アダプタ１４Ａをシリンジ１２から、取り外せる。図１５に示すように、アダプタ付きシリンジ１０Ａでは、キャップ２４に針部材３８Ａが連結されないため、アダプタ１４Ａをシリンジ１２から取り外した際に、キャップ２４がシリンジ１２に残る。ノズル１８は、キャップ２４で封止された状態に保たれる。本実施形態のアダプタ付きシリンジ１０Ａは、注射薬の調整を行ってから注射針を取り付けるまでに、時間を要する場合に、シリンジ１２の注射薬を清浄な状態に保てる。 As shown in FIG. 15, in the syringe with adapter 10A of this embodiment, after the vial 90 is connected to the syringe 12, the adapter 14A can be removed from the syringe 12 by the operation described with reference to FIGS. 9A to 12. . As shown in FIG. 15, in the syringe with adapter 10A, the needle member 38A is not connected to the cap 24, so when the adapter 14A is removed from the syringe 12, the cap 24 remains on the syringe 12. Nozzle 18 is kept sealed with cap 24. The syringe with adapter 10A of this embodiment can keep the injection drug in the syringe 12 clean when it takes time to attach the injection needle after adjusting the injection drug.

上述の開示は、以下にまとめられる。 The above disclosure is summarized below.

一観点は、シリンジ（１２）とバイアル（９０）とを接続するアダプタ（１４、１４Ａ）であって、両頭針（６３）を有し、前記バイアルの口部（９２）と接続可能な針部材（３８、３８Ａ）と、前記針部材を軸線方向に移動可能に保持する保持部材（４４）と、前記シリンジのバレル（１６）の先端部（１６ａ）に連結される連結部（４０）と、を有する接続部材（３４）と、前記連結部に当接して前記連結部の前記シリンジからの離脱を阻止するロック部材（３６、３６Ａ）と、を備え、前記ロック部材は、前記針部材に前記バイアルが押し込まれて前記針部材が前記連結部に接近することにより前記針部材に連結され、前記ロック部材は、前記バイアルが前記シリンジから離間する際に前記針部材及び前記バイアルとともに前記連結部から離間して、前記接続部材の前記シリンジからの離脱を可能とする。 One aspect is an adapter (14, 14A) for connecting a syringe (12) and a vial (90), a needle member having a double-ended needle (63) and connectable to the opening (92) of the vial. (38, 38A), a holding member (44) that holds the needle member movably in the axial direction, and a connecting portion (40) connected to the distal end portion (16a) of the barrel (16) of the syringe; and a locking member (36, 36A) that comes into contact with the connecting portion to prevent the connecting portion from separating from the syringe, the locking member having the connecting portion attached to the needle member. When the vial is pushed in and the needle member approaches the connecting portion, the locking member is connected to the needle member, and when the vial is separated from the syringe, the locking member is removed from the connecting portion together with the needle member and the vial. The connecting member is separated from the syringe to allow the connecting member to be removed from the syringe.

上述のアダプタは、バイアルが接続され、さらにその後にバイアルがシリンジから離間するまで、シリンジに離脱不可能に連結される。したがって、アダプタは、バイアルを取り付ける前にシリンジに注射針を取り付けることを防止し、未調整の注射液の誤投与を防止できる。 The adapter described above is permanently coupled to the syringe until the vial is connected and the vial is subsequently separated from the syringe. Therefore, the adapter prevents attaching the needle to the syringe before attaching the vial, thereby preventing erroneous administration of unconditioned injection solution.

上述のアダプタにおいて、前記連結部は、内方に突出し、前記シリンジの連結溝（２８）に係合する連結突起（４６）を有し、前記連結突起は、前記シリンジに対して周方向に回転することで前記シリンジと前記接続部材との連結状態を解除してもよい。このアダプタは、連結突起で解除可能にシリンジに連結できる。 In the above adapter, the connecting portion has a connecting protrusion (46) that projects inward and engages with the connecting groove (28) of the syringe, and the connecting protrusion rotates in the circumferential direction with respect to the syringe. By doing so, the connection state between the syringe and the connection member may be released. This adapter can be releasably connected to a syringe with a connecting projection.

上述のアダプタにおいて、前記ロック部材は、前記連結突起の周方向に隣接して配置され、前記接続部材の周方向の回転を妨げるロック片（３６ｄ）を有してもよい。このアダプタは、ロック片により、接続部材がシリンジから離脱するのを防止できる。 In the above adapter, the locking member may include a locking piece (36d) that is disposed adjacent to the connecting projection in the circumferential direction and prevents rotation of the connecting member in the circumferential direction. This adapter can prevent the connecting member from detaching from the syringe with the lock piece.

上述のアダプタにおいて、前記ロック片は、前記連結部の内周面と、前記先端部の外周面との間に挿入され、前記連結突起と周方向から当接して前記接続部材の回動を阻止してもよい。このアダプタは、簡素な構成で、接続部材の離脱を防止できる。 In the above-mentioned adapter, the locking piece is inserted between the inner circumferential surface of the connecting portion and the outer circumferential surface of the distal end portion, and contacts the connecting protrusion from the circumferential direction to prevent rotation of the connecting member. You may. This adapter has a simple configuration and can prevent the connection member from coming off.

上述のアダプタにおいて、前記ロック部材は、前記接続部材に当接することで、前記ロック部材を前記接続部材に仮固定する仮止突起（７８）を有してもよい。このアダプタは、ロック部材の離脱を防止することで、接続部材の離脱を防止できる。 In the above-mentioned adapter, the locking member may have a temporary fixing protrusion (78) that temporarily fixes the locking member to the connecting member by coming into contact with the connecting member. This adapter can prevent the connecting member from coming off by preventing the locking member from coming off.

上述のアダプタにおいて、前記ロック部材は嵌合部（５８）を有し、前記針部材は前記嵌合部に嵌合可能な第１爪部材（６０）を有し、前記バイアルが前記針部材に押し込まれると、前記第１爪部材が前記嵌合部に嵌合して前記ロック部材と前記針部材とが連結され、前記バイアルが前記シリンジから離れる方向に変位すると、前記針部材とともに前記ロック部材が前記連結部から引き抜かれて前記連結部の解除を可能としてもよい。このアダプタは、バイアルの引き抜き動作を通じて針部材とともにロック部材の離脱を可能とすることができ、操作性に優れる。 In the above adapter, the locking member has a fitting part (58), the needle member has a first claw member (60) that can be fitted into the fitting part, and the vial is attached to the needle member. When pushed in, the first claw member fits into the fitting portion and the lock member and the needle member are connected. When the vial is displaced in a direction away from the syringe, the lock member and the needle member are pushed in. may be pulled out from the connecting portion to enable release of the connecting portion. This adapter allows the locking member to be removed together with the needle member through the action of pulling out the vial, and has excellent operability.

上述のアダプタにおいて、前記針部材は、前記シリンジの前記先端部を封止するキャップ（２４）に係合する第２爪部材（７１）を有し、前記バイアルが前記針部材に押し込まれると前記第２爪部材が前記キャップに係合し、前記バイアルが前記シリンジから離れる方向に変位すると、前記キャップは、前記針部材とともに前記シリンジから外れてもよい。このアダプタは、シリンジから離脱する際に、キャップを外すことができ、シリンジに素早く注射針を取り付けることができるため、操作性に優れる。 In the above adapter, the needle member has a second pawl member (71) that engages with a cap (24) sealing the tip of the syringe, and when the vial is pushed into the needle member, the second claw member (71) When a second pawl member engages the cap and the vial is displaced away from the syringe, the cap may be removed from the syringe along with the needle member. This adapter has excellent operability because the cap can be removed when detached from the syringe and the injection needle can be quickly attached to the syringe.

別の一観点は、上述観点のアダプタと、内部に医療用液体を収容したシリンジ（１２）と、を備え、前記シリンジの前記先端部に前記アダプタが接続された、アダプタ付きシリンジ（１０、１０Ａ）にある。このアダプタ付きシリンジは、未調整の注射液の誤投与を防止できる。 Another aspect is a syringe with an adapter (10, 10A )It is in. This syringe with an adapter can prevent erroneous administration of unadjusted injection solution.

上述のアダプタ付きシリンジは、前記ロック部材を前記シリンジに仮固定する凹凸構造（２９）を有してもよい。このアダプタ付きシリンジは、ロック部材の離脱を防止することで、接続部材の離脱を防止できる。 The above-mentioned syringe with an adapter may have an uneven structure (29) for temporarily fixing the locking member to the syringe. This syringe with an adapter can prevent the connecting member from coming off by preventing the locking member from coming off.

なお、本発明は、上述した開示に限らず、本発明の要旨を逸脱することなく、種々の構成を採り得る。 Note that the present invention is not limited to the disclosure described above, and can take various configurations without departing from the gist of the present invention.

１０、１０Ａ…アダプタ付きシリンジ１２…シリンジ
１４、１４Ａ…アダプタ１８…ノズル
２４…キャップ２８…連結溝
２９…凹凸構造３４…接続部材
３６、３６Ａ…ロック部材３６ｄ…ロック片
３８、３８Ａ…針部材４０…連結部
４４…保持筒（保持部材）４６…連結突起
５８…嵌合部６３…両頭針
９０…バイアル９２…口部 10, 10A... Syringe with adapter 12... Syringe 14, 14A... Adapter 18... Nozzle 24... Cap 28... Connection groove 29... Uneven structure 34... Connection member 36, 36A... Lock member 36d... Lock piece 38, 38A... Needle member 40 ...Connection part 44...Holding tube (holding member) 46...Connection protrusion 58...Fitting part 63...Double-ended needle 90...Vial 92...Mouth part

Claims

An adapter for connecting a syringe and a vial,
a needle member having a double-ended needle and connectable to the opening of the vial;
a connecting member having a holding member that holds the needle member so as to be movable in the axial direction; and a connecting member that is connected to the distal end of the barrel of the syringe;
a locking member that comes into contact with the connecting portion and prevents the connecting portion from separating from the syringe;
The locking member is coupled to the needle member when the vial is pushed into the needle member and the needle member approaches the coupling portion,
The locking member separates from the connecting portion together with the needle member and the vial when the vial separates from the syringe, thereby allowing the connecting member to be removed from the syringe.

2. The adapter according to claim 1, wherein the connecting portion has a connecting protrusion that protrudes inward and engages with a connecting groove of the syringe, and the connecting protrusion rotates in a circumferential direction with respect to the syringe. An adapter that releases the connection between the syringe and the connecting member.

3. The adapter according to claim 2, wherein the locking member has a locking piece that is disposed adjacent to the connecting projection in the circumferential direction and prevents rotation of the connecting member in the circumferential direction.

4. The adapter according to claim 3, wherein the locking piece is inserted between an inner circumferential surface of the connecting portion and an outer circumferential surface of the distal end portion, and contacts the connecting protrusion from the circumferential direction to prevent the connecting member from being in contact with the connecting protrusion. An adapter that prevents the rotation of the

5. The adapter according to claim 1, wherein the locking member has a temporary fixing protrusion that temporarily fixes the locking member to the connecting member by coming into contact with the connecting member. .

6. The adapter according to claim 1, wherein the locking member has a fitting portion, and the needle member has a first claw member that can fit into the fitting portion. When the vial is pushed into the needle member, the first claw member fits into the fitting part to connect the locking member and the needle member, and when the vial is displaced in a direction away from the syringe, An adapter in which the locking member is pulled out of the connecting portion together with the needle member to enable release of the connecting portion.

7. The adapter according to claim 6, wherein the needle member has a second claw member that engages with a cap that seals the tip of the syringe, and when the vial is pushed into the needle member, the second claw member engages with a cap that seals the tip of the syringe. The adapter wherein when a two-claw member engages the cap and the vial is displaced away from the syringe, the cap is removed from the syringe along with the needle member.

The adapter according to any one of claims 1 to 7,
A syringe containing a medical liquid inside,
A syringe with an adapter, wherein the adapter is connected to the tip of the syringe.

The syringe with an adapter according to claim 8, having an uneven structure for temporarily fixing the locking member to the syringe.