JP5984059B2 - Chemical co-infusion device - Google Patents

Description

  TECHNICAL FIELD The present invention relates to a liquid medicine mixture injection device used for injecting a liquid medicine such as a solution contained in a syringe into a vial containing a medicine such as a powder preparation, and mixing and preparing the medicine and the liquid medicine.

  Conventionally, antibiotics and blood products, such as antibiotics and blood products that are chemically unstable and may be altered, are stored dry in vials sealed with lids such as rubber stoppers. Immediately before, it is prepared by dissolving in a solution such as distilled water, physiological saline, or glucose solution, and administering it to a patient.

  For example, a device described in Patent Document 1 (Japanese Patent Laid-Open No. 2007-260162) is known as a chemical solution co-infusion apparatus that can easily prepare a preparation and a solution stored in a vial in a dry state. Yes. The medicinal solution co-infusion apparatus is slidably disposed between a vial mounting portion to which a mouth portion of a vial is mounted, a syringe mounting portion to which a tip opening portion of a syringe is mounted, and a vial mounting portion and a syringe mounting portion. A double-ended needle member, the relative position of the double-ended needle member with respect to the vial and the syringe, the separated position where the first and second needle portions of the double-ended needle member do not penetrate the lid member of the syringe and the vial, The first / second needle portion of the needle member can be switched to an approach position penetrating the lid member.

  According to such a conventional chemical solution mixture injection device, a syringe and a vial are respectively attached to the syringe attachment part and the vial attachment part, and a user from a pharmaceutical company or the like is in a state where the double-ended needle member is held at a separated position. Can be provided. Therefore, the user simply switches the relative position of the double-ended needle member with respect to the vial and the syringe to the close position, and penetrates the first and second needle portions of the double-ended needle member through the vial and the lid member of the syringe, respectively. Can be made to communicate with each other, and a mixture of a predetermined drug and a liquid can be prepared easily and quickly.

  By the way, when the drug solution after mixing preparation is sucked into the syringe and the syringe is removed from the drug solution co-infusion apparatus, the processing of the lid member attached to the tip opening of the syringe becomes a problem. Specifically, since the lid member is formed of an elastic member such as rubber and is in close contact with the tip opening of the syringe, the lid member is opened when the syringe is removed from the medicinal-solution co-infusion device. It remains attached to the part. Therefore, when the user attaches the prepared syringe with the prepared medicinal solution to the target device, it is necessary to remove the lid member from the tip opening to the syringe, which is complicated. In addition, there was a risk that the drug would contact the user.

  Therefore, in the medicinal-solution mixed injection device described in Japanese Patent Application Laid-Open No. 2011-19704 (Patent Document 2), a peripheral wall is protruded around the first needle portion that penetrates the lid member of the syringe among the double-ended needle members, and the peripheral wall There has been proposed a structure provided with a locking projection protruding inwardly from the top. According to this, in order to allow the lid member of the syringe to penetrate the first needle portion of the double-ended needle member, by pushing the lid member side of the syringe toward the double-ended needle member, the lid member gets over the locking projection and is first It will be pushed in to the base end side of the needle part (see FIGS. 5D and 5E of Patent Document 2). And when removing the syringe which attracted | sucked the chemical | medical solution after preparation from a chemical | medical solution co-infusion apparatus, a latching protrusion is latched by the flange bottom face of a lid member, and a lid member is hold | maintained around the 1st needle part. . Therefore, it is possible to eliminate the need for the user to remove the lid member from the distal end opening of the syringe that has sucked the drug solution.

  However, in the medicinal-solution co-infusion apparatus described in Patent Document 1, the lid member of the syringe is punctured by the double-ended needle member and the vial lid member shown in FIGS. 5 (d) and 5 (e) of the document. It is necessary to push the head toward the base end portion of the first needle portion against the reaction force of the locking projection and get over the locking projection. Then, the user is required to have both a force to penetrate the lid members on both sides by the double-ended needle member and a force to push the lid member on the syringe side so as to get over the locking projection, which is very large during the puncturing operation. Power was required, and the user was overburdened.

JP 2007-260162 A JP 2011-19704 A

  The present invention has been made in the background of the above-mentioned circumstances, and its solution is to reliably remove the lid member of the syringe from the syringe while reducing the force required for mixing and preparing the chemical solution. It is an object of the present invention to provide a medicinal solution co-infusion device having a novel structure that can be held in a closed state.

  Hereinafter, the aspect of this invention made | formed in order to solve such a subject is described. In addition, the component employ | adopted in each aspect as described below is employable by arbitrary combinations as much as possible.

The first aspect of the present invention includes a vial mounting portion to which a mouth portion of a vial is mounted, a syringe mounting portion to which a tip opening portion of a syringe is mounted, and a slide between the vial mounting portion and the syringe mounting portion. A double-ended needle member that is arranged so that the relative position of the double-ended needle member with respect to the vial and the syringe is such that the first needle portion and the second needle portion of the double-ended needle member are the syringe and the vial. In the medicinal-solution co-infusion apparatus in which the separation position that does not penetrate the lid member, and the approach position where the first needle portion and the second needle portion of the double-ended needle member penetrate the lid member can be switched, the syringe mounting part, while the locking projection for holding the lid member engaged with the lid member for covering the distal opening of the syringe into the syringe mounting part is provided, the syringe the syringe Attach to the mounting part And by, said lid member of the syringe is placed into the deeper puncture position of the syringe mounting part rides over the locking protrusion, the first needle relative to said lid member of said syringe held in the puncture position part is characterized that it is so that the penetration.

  According to this aspect, when the syringe is mounted on the syringe mounting portion, the lid member that covers the distal end opening of the syringe gets over the locking projection and is disposed in the back of the syringe mounting portion. Thereby, before the piercing operation | work with respect to the both lid member of a vial and a syringe by a double-headed needle member, the operation | work which moves a lid member of a syringe over a latching protrusion and back can be completed. Therefore, in the state of shipment of the product in which the vial and the syringe are attached to the medical solution mixture injection device and the relative position of the double-ended needle member with respect to the vial and the syringe is kept at the separated position, the operation of overcoming the locking protrusion of the lid member of the syringe has already been performed. Completed. Therefore, when the user mixes and adjusts the drug in the vial and the liquid in the syringe, only the force necessary to puncture the first and second needle portions of the double-ended needle member into the both lid members of the vial and the syringe is required. Therefore, it is possible to advantageously reduce the force required for mixing and preparing the chemical solution.

  On the other hand, since the lid member attached to the distal end opening of the syringe passes over the locking projection provided on the syringe attachment portion and is housed and disposed in the back of the syringe attachment portion, the syringe is opened to the opening of the syringe attachment portion. When pulling out to the side of the part and removing it, the lid member is locked by the locking projection and is securely held behind the syringe mounting part. As described above, by providing the locking projection on the syringe mounting portion, the lid member can be securely attached to the liquid medicine infusion device side, which is impossible with the conventional structure provided on the first needle portion side of the double-ended needle. For the first time, it was possible to achieve both holding and reducing the force required for mixing and preparing chemical solutions.

  According to a second aspect of the present invention, in the medicinal solution co-infusion apparatus according to the first aspect, an inner cylinder member in which the vial mounting part is provided on one end side and the double-ended needle member is provided on the other end side, and one end The syringe mounting part is provided on the side, and the outer cylinder member is provided with an inner cylinder member sliding part on which the inner cylinder member is slidably mounted on the other end side, and the inner cylinder member slide of the outer cylinder member is provided. The inner cylinder member is slidably attached to the moving portion from the double-ended needle member side, and the double-ended needle member is temporarily placed at the separated position between the outer cylindrical member and the inner cylindrical member. A temporary holding mechanism for holding is provided.

  According to this aspect, by utilizing the sliding between the inner cylinder member and the outer cylinder member, the structure for switching between the separation position and the approach position with respect to the vial and the syringe of the first needle portion and the second needle portion of the double-ended needle member is provided. It becomes possible to realize compactly. Moreover, since a temporary holding mechanism for temporarily holding the double-ended needle member at a separated position is provided between the sliding contact surfaces of the outer cylinder member and the inner cylinder member, it is possible to advantageously avoid an increase in the size of the instrument due to the temporary holding mechanism. On the other hand, temporary holding at the separated position of the double-ended needle member that realizes the shipping state can be reliably performed. In addition, as a temporary holding mechanism, the thing by uneven | corrugated fitting provided between the sliding contact surfaces of an outer cylinder member and an inner cylinder member, the thing using the increase in frictional force, etc. can be employ | adopted advantageously.

  According to a third aspect of the present invention, in the medicinal-solution co-infusion device according to the first or second aspect, the syringe mounting portion is formed in a cylindrical shape, and at a position facing the axial direction of the syringe mounting portion, Each of the locking projections protrudes inward.

  According to this aspect, when the syringe is pulled out and removed to the opening side (the upper side in the axial direction) of the syringe mounting portion, both sides of the lid member in the axial direction of the lid member are provided by the locking protrusions protruding from both sides in the axial direction of the syringe mounting portion. Can be held stably. Therefore, the lid member can be more reliably removed from the tip opening of the syringe, and the lid member can be held behind the syringe mounting portion.

  According to a fourth aspect of the present invention, in the drug solution co-infusion apparatus according to any one of the first to third aspects, a plurality of the locking protrusions are provided apart from each other in the circumferential direction.

  According to this aspect, since the plurality of locking projections are provided apart from each other in the circumferential direction, the plurality of locking projections can be locked in a wide range of the lid member, and the lid member is more reliably secured. Can be held behind the syringe mounting portion. Further, since the locking projection is divided into a plurality in the circumferential direction, the drag force when the lid member gets over the locking projection can be advantageously reduced.

  According to a fifth aspect of the present invention, in the medicinal-solution mixed injection device according to any one of the first to fourth aspects, the locking protrusion has a tapered shape that protrudes inward while being inclined obliquely downward. It is what.

  According to this aspect, since the locking projection is formed in a taper shape that protrudes inward while being inclined obliquely downward, when the lid member gets over the locking projection, the lid member follows the taper shape. The pushing force can be reduced by being guided downward. On the other hand, when a force that moves from the back of the syringe mounting portion to the opening side is applied to the lid member, the locking protrusion comes into contact with the lid member in a wedge shape, and a large resistance force against the displacement of the lid member is obtained. It is generated and can be advantageously held behind the syringe mounting portion of the lid member.

  According to a sixth aspect of the present invention, in the chemical solution co-infusion apparatus according to any one of the first to fifth aspects, the locking protrusion protrudes inwardly at one end side of the ring-shaped holding portion so as to be integrated. While the provided projection component is formed separately, the projection component is mounted by fixing the outer peripheral surface of the holding portion to the inner peripheral surface of the back of the syringe mounting portion. It is what has been.

  According to this aspect, it is possible to install the locking protrusion on the syringe mounting portion with a simple structure in which the separately formed protrusion component is fitted and fixed in the back of the syringe mounting portion. Therefore, it is possible to easily manufacture the medicinal solution mixed injection device of the present invention. Moreover, it becomes possible to add a protrusion component part to the existing chemical solution co-infusion apparatus to obtain the same effect as the present invention.

  According to the present invention, by providing a locking projection on the syringe mounting portion, when mounting the syringe on the syringe mounting portion, the operation of moving the lid member of the syringe over the locking projection to the back is completed. Can do. As a result, it was possible to achieve both the reliable holding of the lid member on the side of the medicinal solution mixing device and the reduction of the force required for the mixing and preparing operation of the medicinal solution.

FIG. 4 is a cross-sectional view taken along an axis orthogonal line I with respect to the central axis O shown in FIG. 3, which is a chemical solution co-injection device as the first embodiment of the present invention. FIG. 4 is a cross-sectional view taken along an axis orthogonal line II with respect to the center line O in FIG. The disassembled perspective view of the chemical | medical solution mixed injection apparatus shown in FIG. The perspective view of the processus | protrusion component used for the chemical | medical solution mixed injection instrument shown in FIG. Cross-sectional explanatory drawing explaining the process of mounting | wearing a syringe mounting part with the syringe seen from the direction shown in FIG. Cross-sectional explanatory drawing explaining the usage method of the chemical | medical solution mixed injection device seen from the direction shown in FIG. Cross-sectional explanatory drawing explaining the usage method of the chemical | medical solution mixed injection device seen from the direction shown in FIG.

  Hereinafter, in order to clarify the present invention more specifically, embodiments of the present invention will be described in detail with reference to the drawings.

  First, in FIGS. 1-4, the chemical | medical solution co-infusion apparatus 10 as the 1st Embodiment of this invention is shown. The medicinal-solution co-injection device 10 is configured such that a substantially cylindrical outer cylinder member 14 is assembled to an approximately cylindrical inner cylinder member 12 so as to be slidable in the axial direction. This medicinal solution co-injection device 10 is used for mixing and preparing a medicine and a liquid by communicating a vial 16 and a syringe 18 with each other. Here, FIG. 1 shows a cross-section longitudinally cut by an orthogonal line I orthogonal to the central axis: O of the medicinal solution mixed injection device 10 shown in FIG. 3, and FIG. 2 is an orthogonal line further orthogonal to the orthogonal line I shown in FIG. A section taken along the line II is shown. In the following description, the vertical direction means the vertical direction in FIG. 1, which is the vertical vertical direction, unless otherwise specified.

  In addition, the vial 16 and the syringe 18 attached to the medical solution mixture injection device 10 can be attached to any one having a known standard shape. The vial 16 is made of a glass container 20 that contains a drug such as a powder formulation, a rubber lid member 24 that seals the mouth portion 22 of the container section 20, and a metal that fixes the lid member 24 to the container section 20. It is comprised from the ring member 26 of this. The syringe 18 also has a barrel 28 for storing a solution, a plunger 30 that moves forward and backward with respect to the inside of the barrel 28, and a cylindrical coupling portion 34 that surrounds the outer periphery of the tip opening 32 of the barrel 28. A rubber lid member 36 that seals the tip opening 32 is mounted between the tip opening 32 and the connecting portion 34.

  The inner cylinder member 12 constituting the chemical solution mixture injection instrument 10 is formed of a known material such as a synthetic resin material such as polypropylene, polyethylene, ABS resin, polycarbonate, polystyrene, and has a substantially cylindrical cylindrical body portion 40. ing. One end portion (lower side in FIG. 1) of the cylindrical body portion 40 is opened, so that a vial mounting portion 44 in which the mouth portion 22 of the vial 16 is mounted on one end side of the inner cylindrical member 12 is provided. It is configured. On the other hand, the other end portion (upper side in FIG. 1) of the cylindrical body portion 40 is closed by a partition wall 46 extending in the direction perpendicular to the axis. A first needle portion 48 projects from one side (upper side in FIG. 1) of the partition wall 46, and a second needle portion 50 projects from the other side (lower side in FIG. 1). Has been. The partition wall 46, the first needle portion 48 and the second needle portion 50 constitute a double-ended needle member 52 provided on the other end side of the inner cylinder member 12.

  In the double-ended needle member 52, the first needle portion 48 and the second needle portion 50 protrude from the substantially central portion of the partition wall 46 to the upper and lower sides and extend in the shape of the central axis of the cylindrical portion 40. The projecting dimension of the first needle portion 48 is set to a length sufficient to penetrate the lid member 36 of the syringe 18 that is mounted on a syringe mounting portion 72 (described later) provided on the outer cylinder member 14. On the other hand, the projecting dimension of the second needle part 50 is shorter by a predetermined dimension than the axial dimension of the cylindrical body part 40, and when the mouth part 22 of the vial 16 is attached to the vial attaching part 44, the first needle part is provided. The distal end portion of 48 does not reach the lid member 24 of the vial 16. The first needle portion 48 is formed with a diameter smaller than that of the second needle portion 50, and the puncture resistance through which the first needle portion 48 penetrates the lid member 36 of the syringe 18 is reduced. The puncture resistance that penetrates the lid member 24 of the vial 16 is made smaller.

  A passage 54 is provided in the first needle portion 48 and the second needle portion 50 so as to extend continuously in the axial direction. One end of the passage 54 opens at the distal end of the first needle portion 48, while the other end of the passage 54 opens at the outer peripheral surface of the second needle portion 50, and the vial 54 is passed through the passage 54. The internal space of the 16 container parts 20 and the internal space of the barrel 28 of the syringe 18 are communicated with each other.

  The inner cylinder member 12 is further provided with a pair of syringe detachment preventing members 56 and 56 protruding upward from the partition wall 46. The pair of syringe detachment preventing members 56, 56 protrudes upward in the axial direction at opposing positions spaced apart from each other with the first needle portion 48 protruding from the center of the partition wall 46 interposed therebetween in the axial direction. (See FIG. 2). Each syringe detachment preventing member 56 includes a rectangular protrusion 58 that is slightly curved in an arc shape, and a partial screw portion 60 that is provided at the tip of the rectangular protrusion 58 and protrudes inward in the axial direction. Reinforcing ribs 62 are provided on the outer peripheral surface of each rectangular protruding piece 58, and the strength of the elongated protruding rectangular protrusion 58 is ensured. The function of the syringe detachment preventing member 56 will be described in detail in the usage method described later.

  As shown in FIG. 2 and FIG. 3, on the outer peripheral surface of the cylindrical portion 40 of the inner cylindrical member 12, there are two places on the circumference where the pair of syringe detachment preventing members 56, 56 face each other on the opposite axis. Positioning grooves 64, 64 extending in the axial direction are formed. Also, as shown in FIG. 3, on the outer peripheral surface of the cylindrical body portion 40, at the same position in the axial direction and at a plurality of locations separated from each other in the circumferential direction (in this embodiment, four locations at a 90 ° pitch), A plurality of contact protrusions 68 are formed to protrude.

  Furthermore, on the inner peripheral surface of the cylindrical body portion 40, pressure contact is made in pressure contact with the mouth portion 22 of the vial 16 attached to the vial attachment portion 44 at a plurality of locations (four locations in the present embodiment) separated in the circumferential direction. Ribs 66 are provided extending in the axial direction. As shown in FIG. 1, the inner diameter dimension: φ1 between the pressure-contacting ribs 66, 66 facing each other in the axial direction is slightly smaller than the outer diameter dimension: φ2 of the mouth portion 22 of the vial 16, and the vial mounting portion The mouth portion 22 of the vial 16 attached to 44 is firmly held by the elastic restoring force of the pressure contact rib 66. In addition, a tapered surface 67 that gradually spreads outward is formed at the opening side end portion (lower side in FIG. 1) of each press-contact rib 66. When inserting the mouth portion 22 of the vial 16 into the opening of the vial mounting portion 44, the vial 16 is guided substantially by the tapered surface 67 and positioned substantially coaxially with the vial mounting portion 44. ing.

  On the other hand, the outer cylinder member 14 which comprises the chemical | medical solution mixed injection instrument 10 is formed from the synthetic resin material etc. which are the same as the inner cylinder member 12, and the substantially cylindrical shape with the step by which the diameter dimension was varied in the intermediate part of an axial direction. Presents. As shown in FIGS. 1 and 2, a substantially cylindrical syringe mounting portion 72 is provided on one end side located above the stepped surface 70 provided in the axially intermediate portion of the outer cylinder member 14. ing. In addition, a cylindrical inner cylinder member slide having an inner diameter dimension slightly larger than the outer diameter dimension of the inner cylinder member 12 on the other end side located on the lower side across the step surface 70 of the outer cylinder member 14. The portion 74 has an opening formed downward, and the inner cylinder member 12 is slidably mounted.

  The syringe mounting portion 72 of the outer cylindrical member 14 has a substantially cylindrical shape that is connected to the inner peripheral edge portion of the stepped surface 70 and rises upward in the axial direction, and the connecting portion 34 of the syringe 18 is connected from the axial upper opening 76. It is supposed to be inserted. The inner diameter dimension: φ3 of the syringe mounting portion 72 is slightly larger than the outer diameter dimension: φ4 of the connecting portion 34 of the syringe 18, and the inner peripheral surface of the syringe mounting portion 72 is connected to the connecting portion 34 of the syringe 18. A female screw portion 80 is formed to be screwed into a male screw portion 78 formed on the outer peripheral surface.

  As shown in FIGS. 1 and 2, the inner peripheral surface of the syringe mounting portion 72 is formed with a pair of concave grooves 82 and 82 extending continuously in the axial direction at positions opposed in the axial direction. Thus, the female screw portion 80 has a discontinuous shape cut off in the middle. The groove width dimension (circumferential length) of the pair of concave groove portions 82, 82 is greater than the width dimension (circumferential length) of the rectangular protruding piece 58 of the pair of syringe removal preventing members 56, 56 inserted therein. Is also slightly larger. Further, the bottom surfaces of the concave groove portions 82 and 82 are deepest at the center portion in the width direction and gradually shallow toward both sides in the width direction so that the reinforcing ribs 62 of the pair of inserted syringe removal preventing members 56 and 56 can be accommodated. The substantially V-shaped cross-sectional shape.

  Furthermore, a fitting recess 88 into which a ring-shaped protrusion component 86 formed separately is fitted is formed on the lower opening 84 side which is the back of the syringe mounting portion 72. As shown in FIG. 4, the protrusion component 86 is formed of a known synthetic resin material or the like similar to the inner cylinder member 12 and the outer cylinder member 14, and has a certain substantially elliptical cross section. 90. A pair of recessed groove portions 91, 91 that protrude outward in the axial direction are integrally formed at positions of the pair of holding portions 90, 90 that face each other in the axial direction. The pair of concave groove portions 91 and 91 have a similar shape slightly smaller than the pair of concave groove portions 82 and 82 formed in the inner peripheral surface of the syringe mounting portion 72, and the protruding component 86 is fitted therein. The inner surface of the pair of recessed groove portions 91 and 91 and the inner surface of the pair of recessed groove portions 82 and 82 are configured to be smoothly connected in a state of being fitted in the recess 88.

  In addition, a plurality of tongue-like locking protrusions 92 projecting in a cantilevered state inwardly of the holding portion 90 while being inclined obliquely downward are integrally formed on one end side (upper side in FIG. 1) of the holding portion 90. It is a formed structure. In the present embodiment, three locking projections 92 that are spaced apart from each other in the circumferential direction are provided at positions that oppose each other in the axial direction of the holding portion 90 (see FIG. 4).

  Such a protrusion component 86 is mounted and held by fitting the outer peripheral surface of the holding portion 90 to the fitting recess 88 formed in the inner peripheral surface at the back of the syringe mounting portion 72. Yes. As shown in a partially enlarged view in FIG. 1, an engagement protrusion 94 is provided on the outer peripheral surface of the protrusion component 86, and an engagement recess formed in the inner peripheral surface of the fitting recess 88. By fitting in 96, the protruding component 86 is fixedly positioned and held in the fitting recess 88. Further, the lower flange portion 98 in the holding portion 90 of the projection component 86 abuts on the lower shaft straight end surface 100 of the fitting recess 88, or the upper end surface 102 of the holding portion 90 is on the upper side of the fitting recess 88. By abutting against the shaft straight end face 104, the protruding component 86 is firmly positioned and held against the upward pulling force.

  In addition, the inner cylinder member sliding portion 74 of the outer cylinder member 14 is fitted on a pair of positioning grooves 64 and 64 that are provided on the outer periphery of the inner cylinder member 12 and face each other in the axial direction. A pair of positioning ribs 106, 106 are formed to extend continuously in the axial direction at positions facing each other in the direction perpendicular to the axis. Further, a first circumferential groove 108, a second circumferential groove 110, and a third circumferential groove 112 extending continuously in the circumferential direction are formed on the inner circumferential surface of the inner cylinder member sliding portion 74 at three different axial positions. Has been. When the inner cylinder member 12 is slidably mounted on the inner cylinder member sliding portion 74, the contact protrusions 68 formed on the outer peripheral surface of the inner cylinder member 12 are respectively first, second, The relative positions of the inner cylinder member 12 and the outer cylinder member 14 can be switched by being fitted and temporarily held in the third circumferential grooves 108, 110, and 112. Thereby, the relative position of the double-ended needle member 52 with respect to the vial 16 and the syringe 18 attached to the medicinal-solution co-injection device 10 can be switched. In short, in this embodiment, the sliding of the inner cylinder member 12 and the outer cylinder member 14 is skillfully used to cover the vial 16 of the double-ended needle member 52 and the vial 16 of the second needle part 50 and the lid of the syringe 18. The structure for switching between the separation position and the approach position with respect to the members 24 and 36 can be realized in a compact manner.

  As shown in FIG. 3, the inner cylinder member 12 and the outer cylinder member 14 having such a structure are configured such that the inner cylinder member 12 is a double-ended needle member 52 with respect to the inner cylinder member sliding portion 74 of the outer cylinder member 14. By inserting and assembling from the side, the medicinal-solution mixed injection device 10 of the present embodiment is configured. Here, when the inner cylinder member 12 is assembled to the outer cylinder member 14, first, the inner cylinder of the outer cylinder member 14 is opposed to the pair of positioning grooves 64 and 64 formed on the outer peripheral surface of the inner cylinder member 12. By fitting a pair of positioning ribs 106 and 106 formed on the inner peripheral surface of the member sliding portion 74, the relative positions in the circumferential direction of the inner cylinder member 12 and the outer cylinder member 14 are positioned. The inner cylinder member 12 is mounted so as to be slidable in the axial direction with respect to the inner cylinder member sliding portion 74 of the outer cylinder member 14 while maintaining the positioning state.

  Further, when the inner cylinder member 12 is inserted into the inner cylinder member sliding portion 74, a contact protrusion 68 formed on the outer circumferential surface of the inner cylinder member 12 is formed on the inner circumferential surface of the inner cylinder member sliding portion 74. The first circumferential groove 108 is fitted. Thereby, the inner cylinder member 12 is temporarily held in the ready state of the medicinal-solution co-infusion device 10 shown in FIGS. 1 and 2 assembled with the inner cylinder member 12 protruding most from the outer cylinder member 14. In such an assembled state, the relative positions in the circumferential direction of the inner cylinder member 12 and the outer cylinder member 14 are stably held by the fitting of the positioning concave grooves 64 and the positioning ribs 106, so that they are provided in the inner cylinder member 12. The pair of syringe detachment preventing members 56, 56 thus formed are reliably aligned with the pair of concave groove portions 82, 82, 91, 91 provided in the syringe mounting portion 72 of the outer cylinder member 14, thereby preventing the detachment of each syringe. The member 56 is smoothly inserted into the concave groove portions 82 and 91 (see FIG. 2).

  Next, based on FIGS. 5-7, the usage method of the chemical injection device 10 of this embodiment is demonstrated. 5 illustrates a process of mounting the syringe 18 on the syringe mounting section 72 in the cross section shown in FIG. FIG. 6 shows each use state from the state in which the medicinal-solution co-injection device 10 to which the syringe 18 is attached and the vial 16 is attached to the vial attachment portion 44 in the cross section shown in FIG. Further, FIG. 7 shows each use state from the state in which the drug solution co-injection device 10 to which the syringe 18 is attached and the vial 16 is attached to the vial attachment portion 44 in the cross section shown in FIG.

  As shown in FIG. 5A, in the syringe mounting portion 72, the syringe 18 is mounted on the syringe mounting portion 72 by screwing the male screw portion 78 of the syringe 18 with the female screw portion 80 of the syringe mounting portion 72. The With this screwing, the lid member 36 that covers the distal end opening 32 of the syringe 18 comes into contact with a locking projection 92 that projects inward of the syringe mounting portion 72. Since the lid member 36 has an outer diameter that is slightly smaller than the inner diameter of the syringe mounting portion 72, the cantilevered locking projection 92 that protrudes inward of the syringe mounting portion 72 is elastically deformed downward. Will be pushed downward. In the present embodiment, since the three locking projections 92 are spaced apart from each other in the circumferential direction, the drag force when the lid member 36 gets over the locking projection 92 is advantageously reduced. Yes.

  Further, as shown in FIG. 5B, in the mounting state of the syringe 18 to the syringe mounting portion 72 in which the male screw portion 78 of the syringe 18 and the female screw portion 80 of the syringe mounting portion 72 are completely screwed to the final end, The lid member 36 rides over a locking projection 92 projecting from the inner peripheral surface of the syringe mounting portion 72 and is further disposed behind the syringe mounting portion 72 (downward in FIG. 5B). In addition, since the lid member 36 is disposed behind the latch protrusion 92, the latch protrusion 92 is elastically restored to the initial shape, and is positioned axially above the lid member 36. It protrudes inward in the direction perpendicular to the axis. From this state, when the inner cylinder member 12 is further inserted into the inner cylinder member sliding portion 74, a contact protrusion 68 formed on the outer peripheral surface of the inner cylinder member 12 is formed as shown in FIG. The inner cylinder member 12 is fitted into the second circumferential groove 110 formed on the inner circumferential surface of the inner cylinder member sliding portion 74, and the inner cylinder member 12 is temporarily held with respect to the inner cylinder member sliding portion 74 at that position. 6A, which will be described later, in the state shown in FIG. 5C, the partial screw portion 60 provided on the syringe detachment preventing member 56 is continuous with the female screw portion 80 of the syringe mounting portion 72. Without being done, it is arranged at a position shifted in the axial direction. As a result, even if the syringe 18 is rotated in this state, the male screw portion 78 of the syringe 18 cannot be screwed into the female screw portion 80 of the syringe mounting portion 72, and the syringe mounting portion 72 before the adjustment of the medicine is performed. The malfunction which makes 18 disengage is prevented.

  As shown in FIGS. 6 (a) and 7 (a), the medical solution mixed injection device 10 in which the syringe 18 is mounted on the syringe mounting portion 72 and is in the state shown in FIG. The vial 16 is mounted on the vial mounting portion 44 of the drug solution co-injection device 10. In the vial mounting portion 44, the vial mounting portion 44 is guided by the taper surface 67 of the press-contacting rib 66 provided in the vial mounting portion 44 so that the lid member 24 of the vial 16 slightly enters the vial mounting portion 44. Attached to the vial 16. In this state, the second needle portion 50 of the double-ended needle member 52 is held at a separated position that does not penetrate the lid member 24 of the vial 16. Further, the inner cylinder member 12 has a contact protrusion 68 provided on the outer peripheral surface thereof until the position where the second cylindrical groove 110 provided in the inner cylinder member sliding portion 74 of the outer cylinder member 14 is fitted. The inner cylinder member sliding portion 74 is pushed inward. Thus, in the state of FIG. 6A and FIG. 7A in which the relative positions of the inner cylinder member 12 and the outer cylinder member 14 are temporarily held, the first needle portion 48 of the double-ended needle member 52 is the syringe 18. The lid member 36 is held at a separated position that does not pass through. As is clear from these descriptions, in this embodiment, both heads are supported by the cooperation of the pressure contact rib 66 of the vial mounting portion 44, the contact protrusion 68 of the inner cylinder member 12, and the second circumferential groove 110 of the outer cylinder member 14. A temporary holding mechanism is configured to temporarily hold the first needle portion 48 and the second needle portion 50 of the needle member 52 at a distance apart from the lid members 24 and 36.

  According to the medicinal-solution mixed injection device 10 of the present embodiment, as shown in FIGS. 6A and 7A, the vial 16 is mounted on the vial mounting portion 44 of the medicinal-solution mixed injection device 10, and the syringe mounting portion 72 is mounted. While the syringe 18 is mounted and the double-ended needle member 52 is held at the separated position, it can be shipped from a pharmaceutical company or the like to a user. In short, the mounting process of the syringe 18 to the syringe mounting part 72 shown in FIGS. 5 (a), 5 (b), and 5 (c) and the vial mounting part 44 of the vial 16 shown in FIGS. 6 (a) and 7 (a). Up to the mounting process can be performed at the manufacturing factory, which makes it possible to reduce the use process by the user. As described above, in such a shipping state, the partial screw portion 60 provided on the syringe detachment preventing member 56 is not continuously connected to the female screw portion 80 of the syringe mounting portion 72 but is disposed at a position shifted in the axial direction. (See FIG. 6A), the malfunction of detaching the syringe 18 from the syringe mounting portion 72 before the adjustment of the medicine is prevented.

  Subsequently, as shown in FIGS. 6B and 7B, the user uses a double-ended needle member 52 to dissolve the drug 120 contained in the vial 16 with the solution 122 contained in the syringe 18. The first needle portion 48 and the second needle portion 50 are switched to an approach position penetrating the lid member 36 of the syringe 18 and the lid member 24 of the vial 16. Specifically, the syringe 18 is pushed downward. Thereby, first, the fitting between the contact protrusion 68 of the inner cylinder member 12 and the second circumferential groove 110 of the outer cylinder member 14 is released, and the inner cylinder member 12 moves further to the inner cylinder member sliding portion 74. Then, the abutting protrusion 68 is fitted in the third circumferential groove 112, and the partition wall 46 of the inner cylinder member 12 is abutted and held on the step surface 70 of the outer cylinder member 14. As a result, the first needle portion 48 of the double-ended needle member 52 is moved and held at an approach position that penetrates the lid member 36 of the syringe 18. At substantially the same time, the vial 16 is press-fitted to the back of the vial mounting portion 44, and the top surface of the lid member 24 of the vial 16 is held in contact with the partition wall 46. As a result, the second needle portion 50 of the double-ended needle member 52 is moved and held at an approach position that penetrates the lid member 24 of the vial 16. As a result, the inside of the container portion 20 of the vial 16 and the inside of the barrel 28 of the syringe 18 are communicated with each other through the passage 54 of the double-ended needle member 52, and mixing adjustment of the drug solution becomes possible.

  Then, as shown in FIGS. 6C, 6D, 7C, and 7D, the user presses the plunger 30 of the syringe 18 to cause the solution 122 in the barrel 28 to flow into the vial 16. It is injected into the container part 20 and mixed with the medicine 120 in the container part 20 for adjustment. Next, as shown in FIGS. 6 (e) and 7 (e), the user moves the vial 16 and the syringe 18 up and down to move the adjusted mixed drug solution 124 into the barrel 28 of the syringe 18. By pulling the plunger 30 of the syringe 18 in the inverted state, the mixed drug solution 124 in the container portion 20 of the vial 16 is sucked into the barrel 28 of the syringe 18.

  When suction of the mixed drug solution 124 into the barrel 28 is completed, as shown in FIGS. 6 (f) and 7 (f), the user rotates the syringe 18, and the connecting portion 34 of the syringe 18 is moved to the syringe mounting portion. 72. At this time, the inner cylinder member 12 is pushed into the inner cylinder member sliding portion 74 of the outer cylinder member 14, and is formed in the syringe mounting portion 72 as shown in FIGS. 6 (b) to 6 (f). The female screw portion 80 and the partial screw portion 60 of the syringe detachment preventing member 56 are connected to each other. Accordingly, relative rotation of the female screw portion 80 formed in the syringe mounting portion 72 and the male screw portion 78 formed in the connecting portion 34 of the syringe 18 is allowed, and the syringe 18 can be detached from the syringe mounting portion 72.

  At this time, the lid member 36 attached to the distal end opening portion 32 of the syringe 18 is attached to the opening side of the syringe attachment portion 72 (FIGS. 6 (f) and 7) as the syringe 18 is detached from the syringe attachment portion 72. (F) The external force toward the lower side is exerted. However, since a locking projection 92 that protrudes inward in the axial direction from the outer peripheral edge of the lid member 36 is provided directly below the lid member 36, the locking projection 92 is engaged with the lid member 36. The lid member 36 is prevented from coming off from the syringe mounting portion 72. As a result, the lid member 36 is detached from the distal end opening 32 of the syringe 18 and is held as it is behind the syringe mounting portion 72. Accordingly, as shown in FIGS. 6 (f) and 7 (f), the user only has to remove the syringe 18 from the syringe mounting portion 72, and remove the lid member 36 from the distal end opening 32 of the syringe 18 or the like. This is unnecessary.

  As described above, according to the medicinal-solution mixed injection device 10 in the present embodiment, when the syringe 18 is mounted on the syringe mounting portion 72, the lid member 36 gets over the locking projection 92 and is located behind the syringe mounting portion 72. They are arranged (see FIGS. 6A and 7A). That is, such work is completed by the shipping state before the puncturing work for the vial 16 and the lid members 24 and 36 of the syringe 18 by the double-ended needle member 52 shown in FIGS. 6B and 7B. Can do. Therefore, when the user mixes and adjusts the drug 120 in the vial 16 and the solution 122 in the syringe 18, the first needle portion 48 and the second needle portion 50 of the double-ended needle member 52 are placed on both the lids of the vial 16 and the syringe 18. Since only the force necessary for puncturing the members 24 and 36 is required, it is possible to advantageously reduce the working force required for the user in the mixing and preparing work of the chemical solution.

  Moreover, since the lid member 36 of the syringe 18 gets over the locking projection 92 provided on the syringe mounting portion 72 and is housed and disposed in the back of the syringe mounting portion 72, the syringe 18 is opened in the syringe mounting portion 72. When the cover member 36 is pulled out to be removed and is removed, the lid member 36 is locked by the locking protrusion 92 and can be reliably held behind the syringe mounting portion 72. In short, in this embodiment, by providing the locking projection 92 at a predetermined position of the syringe mounting portion 72, the lid member 36 is reliably held on the side of the medicinal solution mixed injection device 10, and the mixture preparation of the drug 120 and the solution 122 is performed. It is possible to advantageously achieve both the reduction of the force required for the work.

  In particular, since a plurality of locking projections 92 (three in the present embodiment) project inward at positions facing each other in the direction perpendicular to the axis of the syringe mounting portion 72, the lid together with the syringe 18 is covered. When the member 36 is pulled out to the opening side of the syringe mounting portion 72, both sides of the lid member 36 in the axial direction can be stably held by the locking projections 92, and the lid member 36 is securely held at the tip of the syringe 18. It can be removed from the opening 32 and held behind the syringe mounting portion 72. Moreover, each locking projection 92 has a tapered shape that protrudes inward in the axial direction of the syringe mounting portion 72 while being inclined obliquely downward in the axial direction from the opening of the syringe mounting portion 72 to the back. . Accordingly, when the lid member 36 gets over the locking projection 92, the lid member 36 is guided downward along the taper shape, thereby reducing the pushing force. On the other hand, when a force that moves from the back of the syringe mounting portion 72 to the opening side is applied to the lid member 36, the locking protrusion 92 abuts against the lid member 36 in a wedge shape to generate a large resistance force. Thus, the lid member 36 can be more securely held behind the syringe mounting portion 72.

  Further, in the present embodiment, the protrusion component 86 formed separately is fitted into the fitting recess 88 formed at the back of the syringe mounting portion 72 and opened to the inner cylinder member sliding portion 74 side. The locking protrusion 92 can be installed at a predetermined position of the syringe mounting portion 72 with a simple structure to be fixed, and the medicinal-solution mixed injection device 10 can be easily manufactured.

  As mentioned above, although embodiment of this invention was explained in full detail, this invention is not limited by the specific description. In the above embodiment, the sliding of the inner cylinder member 12 and the outer cylinder member 14 is utilized to make the first needle portion 48 of the double-ended needle member 52 and the vial 16 of the second needle portion 50 and the lid members 24 and 36 of the syringe 18. In addition to this structure, for example, as disclosed in Patent Document 1, a syringe mounting part 72 and a vial mounting part 44 are provided above and below the cylinder. A structure in which the double-ended needle member 52 is slidably accommodated inside the cylinder can also be employed. In this case, a locking projection 92 is protruded at a predetermined position of a syringe mounting portion 72 provided above the cylinder, the syringe 18 is mounted on the syringe mounting portion 72, and the double-ended needle member 52 is placed in the separated position. In this state, the lid member 36 of the syringe 18 may be positioned behind the syringe mounting portion 72 over the locking projection 92.

  The separate protrusion component 86 is not necessarily adopted, and a boss-like locking protrusion may be directly formed on the inner surface of the syringe mounting portion 72. Further, the shape and number of the locking projections can be arbitrarily set in consideration of the shape of the lid member 36 of the syringe 18 and the like.

10: chemical solution co-injection device, 12: inner cylinder member, 14: outer cylinder member, 16: vial, 18: syringe, 22: mouth, 24: lid member, 26: ring member, 32: tip opening, 36: lid Member, 44: vial mounting part, 48: first needle part, 50: second needle part, 52: double-ended needle member, 68: contact protrusion (holding mechanism), 72: syringe mounting part, 86: protrusion component, 92: Locking projection, 110: Second circumferential groove

Claims (6)

A vial mounting part to which the mouth of the vial is mounted;
A syringe mounting portion to which the tip opening of the syringe is mounted;
A double-ended needle member slidably disposed between the vial mounting portion and the syringe mounting portion;
The relative position of the double-ended needle member with respect to the vial and the syringe is a separated position where the first and second needle portions of the double-ended needle member do not penetrate the lid member of the syringe and the vial; In the medicinal-solution co-infusion device in which the first needle portion and the second needle portion can be switched to an approach position penetrating the lid member,
While the syringe mounting portion is provided with a locking projection for locking to the lid member that covers the tip opening of the syringe and holding the lid member on the syringe mounting portion,
By mounting the syringe on the syringe mounting portion, the lid member of the syringe gets over the locking projection and is disposed at the puncture position at the back of the syringe mounting portion, and the syringe held in the puncture position the first needle portion is turned so that the penetrating to the cover member,
A medicinal solution mixed injection device characterized by that. An inner cylinder member provided with the vial mounting portion on one end side and the double-ended needle member on the other end side;
The syringe mounting part is provided on one end side, and an outer cylinder member provided with an inner cylinder member sliding part on which the inner cylinder member is slidably mounted on the other end side,
The inner cylinder member is slidably mounted from the double-ended needle member side with respect to the inner cylinder member sliding portion of the outer cylinder member, and between the outer cylinder member and the inner cylinder member, The medicinal-solution co-infusion device according to claim 1, further comprising a holding mechanism that temporarily holds the double-ended needle member at the separated position.   The said syringe mounting part is made into the cylinder shape, The said latching protrusion is each protrudingly provided inwardly in the position which opposes the axial direction of this syringe mounting part, respectively. Chemical solution co-infusion device.   The medicinal-solution co-infusion device according to any one of claims 1 to 3, wherein a plurality of the locking protrusions are provided apart from each other in the circumferential direction.   The medicinal-solution co-injection device according to any one of claims 1 to 4, wherein the locking projection has a tapered shape that projects inward while being inclined obliquely downward.   A protrusion component is integrally formed on one end side of the ring-shaped holding portion so that the locking protrusion protrudes inward, and the protrusion component is formed at the back of the syringe mounting portion. The medicinal-solution co-infusion device according to any one of claims 1 to 5, which is attached to the inner peripheral surface of the holding portion by fitting and fixing the outer peripheral surface of the holding portion.

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