CN113679528A - Multi-dose ophthalmic sterile powder delivery system - Google Patents
Multi-dose ophthalmic sterile powder delivery system Download PDFInfo
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- CN113679528A CN113679528A CN202010421610.4A CN202010421610A CN113679528A CN 113679528 A CN113679528 A CN 113679528A CN 202010421610 A CN202010421610 A CN 202010421610A CN 113679528 A CN113679528 A CN 113679528A
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- Prior art keywords
- bottle
- dose
- sterile
- delivery system
- powder
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- 239000000843 powder Substances 0.000 title claims abstract description 49
- 239000003889 eye drop Substances 0.000 claims abstract description 44
- 239000007788 liquid Substances 0.000 claims abstract description 22
- 239000007787 solid Substances 0.000 claims abstract description 21
- 239000003085 diluting agent Substances 0.000 claims abstract description 19
- 229940012356 eye drops Drugs 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- -1 polyethylene Polymers 0.000 claims description 7
- 239000004743 Polypropylene Substances 0.000 claims description 3
- 238000004108 freeze drying Methods 0.000 claims description 3
- 229920001155 polypropylene Polymers 0.000 claims description 3
- 239000004698 Polyethylene Substances 0.000 claims description 2
- 239000004793 Polystyrene Substances 0.000 claims description 2
- 229920000728 polyester Polymers 0.000 claims description 2
- 229920000573 polyethylene Polymers 0.000 claims description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 2
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 2
- 229920002223 polystyrene Polymers 0.000 claims description 2
- 230000000845 anti-microbial effect Effects 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 239000012058 sterile packaged powder Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 11
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 10
- 238000012377 drug delivery Methods 0.000 abstract description 9
- 229940079593 drug Drugs 0.000 abstract description 8
- 239000002502 liposome Substances 0.000 abstract description 4
- 239000000693 micelle Substances 0.000 abstract description 4
- 239000002105 nanoparticle Substances 0.000 abstract description 4
- 239000000126 substance Substances 0.000 abstract description 3
- 239000002245 particle Substances 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 239000000022 bacteriostatic agent Substances 0.000 description 4
- 210000003128 head Anatomy 0.000 description 4
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 3
- 229960004716 idoxuridine Drugs 0.000 description 3
- 239000011859 microparticle Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 208000030533 eye disease Diseases 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 108010036949 Cyclosporine Proteins 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 229960001265 ciclosporin Drugs 0.000 description 1
- 229930182912 cyclosporin Natural products 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 229920001684 low density polyethylene Polymers 0.000 description 1
- 239000004702 low-density polyethylene Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 229940126589 solid medicine Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Closures For Containers (AREA)
Abstract
The invention relates to a multi-dose ophthalmic sterile powder administration system, which comprises a liquid supply bottle A containing diluent and a liquid dropping bottle B containing solid powder and provided with a plurality of doses of sterile administration drippers. The liquid supply bottle A consists of seven parts, including a can cap 1, a threaded can 2, an inner needle 3, an empty cylinder 4, a piston 5, a piston shaft 6 and a support handle 7. The piston shaft is provided with a fixing buckle 8, so that the piston shaft can be prevented from falling off; the threaded can 2 is used for being connected with the bottle bottom of the B bottle with built-in threads, and the inner needle 3 is used for puncturing the bottle bottom 10 protected by the B bottle antibacterial plug 9; the can cap 1 is used for protecting the A-bottle can and the inner needle. The eye drop bottle B consists of four parts, including an antibacterial plug 9 at the bottom, a bottle bottom 10 with internal thread, a bottle body 11 and a multi-dose aseptic administration dropper 12. The invention has novel structure and reasonable design, and can realize that drugs with unstable chemical properties in a liquid state or special particle drug delivery systems such as nanoparticles, liposomes, micelles and the like are used for eye drug delivery.
Description
Technical Field
The invention belongs to the technical field of drug delivery containers, and particularly relates to a multi-dose eye drop sterile powder drug delivery system.
Background
Most of eye drops in the current market exist in a solution form, but chemical properties of a plurality of medicines are unstable, and the degradation of the medicines is accelerated in a water solution state, so that hidden danger is brought to the medication safety; especially, some special microparticle drug delivery systems such as nanoparticles, liposomes, micelles and the like are unstable in a liquid state and cannot be stored for a long time, so that the application of the drug delivery systems to the treatment of eye diseases is limited. The traditional liquid eye drops are prepared into a solid preparation added with diluent and dissolved before use, so that the stability of the medicine can be improved, the medicine is prevented from being degraded in the solution, the stability of the micro-particle administration system is improved, and the eye disease administration by the eye drop method is possible.
The existing eye drop bottle package designs mainly include the following types:
(1) common solution type multi-dose eye drop bottle: the eye drop bottle is a common plastic packaging bottle which takes low-density polyethylene and polypropylene as materials, and the content is added with the bacteriostatic agent more, so that the eye drop bottle is ensured not to be infected with bacteria after being opened and can be used repeatedly, but the bacteriostatic agent can damage eyes after being used for a long time.
(2) Solid formulation + multi-dose eye drop bottle in solution form: the eye drop is prepared by separately packaging solid medicine and solvent, adding a bottle of solvent, making the medicine into tablet (pill) or powder, and adding the tablet (or powder) into the solvent according to the dosage of the specification before use to make it fully dissolved and uniformly shaken to obtain eye drop.
(3) Multi-dose sterile eye drops bottles: restasis Multidose from Allergan corporationTM(Cyclosporine opthalmic 0.05% w/v) the multi-dose sterile eye drop bottle is provided with a special administration dropper, so that the liquid eye drop does not contain bacteriostatic agent, and the eye drop bottle sample is ensured not to be polluted and infected by bacteria after being used for multiple times.
However, these prior designs all have certain disadvantages such as: (1) the existing 'solid + liquid' form eye drop administration device can not realize seamless mixing and dissolving of liquid and solid, and the operation process of a common patient is easy to contaminate bacteria, thereby bringing risks to application. (2) Multiple dose eye drops and sterile multiple dose eye drops are also not suitable for use in liquid form for ophthalmic delivery of chemically unstable drugs or special microparticle delivery systems.
Disclosure of Invention
Based on the above problems, the present inventors have tried and designed several times to provide a multi-dose eye drop sterile powder delivery system which can be used for solid powders, especially for some drugs which are unstable chemically in liquid state, and some special particulate delivery systems such as nanoparticles, liposomes, micelles which are unstable in liquid state and must be stored in solid powder form, and can be dissolved by adding a diluent at the time of use to facilitate the delivery.
The invention provides a multi-dose eye sterile powder delivery system, which comprises a liquid supply bottle A containing diluent and an eye drop bottle B containing solid powder and provided with a multi-dose sterile delivery dropper. The liquid supply bottle A consists of seven parts, including a support handle, a piston shaft, a piston, an empty cylinder, a can with screw threads, an inner needle and a can cap. The piston shaft is provided with a fixing buckle, so that the piston shaft can be prevented from falling off and flowing back; the can with the threads and the inner needle are provided with the threads for being connected with the bottom of the B bottle with the built-in threads, and the inner needle is used for puncturing the bottom protected by the B bottle antibacterial plug; the can cap is used for protecting the can head and the inner needle of the bottle A and isolating the outside from contacting with the liquid contained in the bottle A, thereby ensuring the sterility. The eye drop bottle B consists of four parts, including an antibacterial plug at the bottom of the bottle, a bottle bottom with internal threads, a bottle body and a multi-dose aseptic administration dropper; the multi-dose aseptic administration dripper is provided with a dripper, a spring, a top seal, an air filter and a tip hole, and can also adopt a multi-dose aseptic administration dripper which is currently marketed, such as those adopted by Allergan company or other commercialized drippers.
The invention provides a multi-dose eye drop sterile powder delivery system, which is used by the following method: taking down the can cap of the bottle A, taking down the antibacterial plug at the bottle bottom of the bottle B, aligning the can with the thread of the bottle A with the bottle bottom of the bottle B with the thread, screwing up the can with the thread of the bottle A, puncturing the bottle bottom of the bottle B by an inner needle of the can with the thread of the bottle A, pushing the supporting handle of the bottle A to push the diluent contained in the bottle A into the bottle B, shaking the bottle B, dissolving the powder of the bottle B, and preparing the eye drops for treatment; the external cover is removed when the eye drops are dropped, and the eye drop can be used. After the dripping is finished, the outer cover of the dripper is covered. Because the piston shaft of the bottle A is provided with the fixing buckle, the piston shaft can be ensured not to fall off to cause liquid backflow, the screw of the can head of the bottle A is tightly connected with the bottle bottom of the built-in thread of the bottle B through the screw, and the bottle A at the back stably exists as the bottom support of the whole drug delivery system.
The solid powder contained in the eye drop bottle B provided by the invention can be sterile subpackaged powder or freeze-dried powder obtained by a freeze-drying process. The materials used for forming the eye drop bottle A and the eye drop bottle B of the multi-dose eye drop sterile powder delivery system provided by the invention are single materials such as polyethylene, polypropylene, polystyrene, polyethylene terephthalate, polyester and the like or mixed materials thereof.
Drawings
FIG. 1 is a drawing of a multi-dose sterile powder delivery system for eye use according to the present invention, wherein A is a bottle A containing a diluent, B is an eye drop bottle B containing a solid powder and having a multi-dose sterile delivery dropper
FIG. 2 is a view showing the A bottle of the diluent-containing liquid supply bottle in the sterile powder administration system for multi-dose ophthalmic use according to the present invention
FIG. 3 is a cross-sectional view of the diluent-containing bottle A of the sterile powder drug delivery system for multi-dose ophthalmic use according to the present invention
FIG. 4 shows an eye dropper bottle B containing solid powder and having multiple-dose sterile administration dropper according to the present invention
FIG. 5 is a drawing showing an eye dropper bottle B containing solid powder and having a multi-dose sterile administration dropper, according to the present invention, in the multi-dose sterile powder administration system for eyes
FIG. 6 shows a multi-dose sterile powder dropper for eyes according to the invention, wherein the dropper B can contain solid powder and has multiple-dose sterile administration dropper
FIG. 7 is a multi-dose ophthalmic sterile powder delivery system of the present invention
In the figure, 1-can cap, 2-can with screw thread, 3-inner needle, 4-empty cylinder, 5-piston, 6-piston shaft, 7-support handle, 8-buckle, 9-bottle bottom anti-bacteria plug, 10-bottle bottom with internal screw thread, 11-bottle body, 12-multi-dose aseptic administration dropper part, 13-air filter, 14-applicator, 15-spring, 16-tip hole, 17-core, 18-top seal, 19-spray needle, 20-dropper cap, 21-dropper.
Detailed Description
The invention will be illustrated in more detail in the following non-limiting examples in connection with the description.
Referring to fig. 1-7, the present invention relates to a multi-dose sterile powder delivery system for ophthalmic use, comprising a liquid supply bottle a containing a diluent and an eye drop bottle B containing a solid powder and having a multi-dose sterile administration dropper. Mainly used for some medicines which are unstable in chemical properties in a liquid state, and some special particle administration systems which are unstable in a liquid state and must be stored in a solid powder form, such as nanoparticles, liposomes, micelles and the like, are dissolved by adding a diluent when in use, so that the ophthalmic administration of the medicines is realized, and the multi-dose sterile eye drop administration of the solid powder without adding any bacteriostatic agent is possible.
Fig. 1A is a diluent a bottle of the present invention, and fig. 1B is an eye drop bottle B of the present invention containing a solid powder and having a multi-dose sterile administration dropper. As shown in figure 2, the bottle A is composed of a can cap 1, a threaded can 2, an inner needle 3, an empty cylinder 4, a piston 5, a piston shaft 6, a support handle 7 and a buckle 8. The can cap 1 is used for protecting the can 2 and the inner needle 3 and preventing contamination caused by bacteria contamination, the inner needle 3 is used for puncturing the center position of the bottom of the bottle protected by the B bottle antibacterial plug 9, and the inner tube of the inner needle is communicated with the bottle A and the bottle B, so that the diluent of the bottle A can be conveniently infused into the bottle B; the can 2 with the screw thread is convenient to be connected and fixed with the bottle bottom 10 with the screw thread arranged in the bottle B in a rotating way; the empty cylinder 4 is used for containing a diluent, and the volume of the empty cylinder can be adjusted according to the requirement; the piston 5 is used for sealing the diluent contained in the hollow cylinder 4 and pushing the diluent into the bottle body 11 of the bottle B through the inner needle 2 by pushing through the piston shaft 6; the supporting handle 7 is convenient for pushing the piston shaft 6 and plays a role of a bracket, so that the bottles A and B can be erected on a plane after being combined; the snap 8 ensures that the piston shaft 6 does not fall off or flow back after pushing the piston 5 to transfer the diluent from the a bottle to the B bottle as shown in fig. 3.
Fig. 4 and 5 show an eye dropper bottle B for solid powder according to the invention with a multi-dose sterile administration dropper. As shown in figure 4, the bottle B consists of a bottle bottom anti-bacteria plug 9, a bottle bottom 10 with an internal thread, a bottle body 11 and a multi-dose sterile administration dropper part 12. The bottle bottom anti-bacterial plug 9 is used for protecting the bottle bottom 10 with the built-in thread and preventing the part from being infected with bacteria, so that the liquid in the bottle A is squeezed into the bottle B to pollute the bottle B in the later period; the bottle body 11 is used for containing solid powder, and the powder can be sterile subpackaged powder or freeze-dried powder obtained by adopting a freeze-drying process; the multi-dose sterile administration dropper 12 is shown in fig. 6 as comprising a dropper cap 20 and a dropper 21 comprising an air filter 13, an applicator 14, a spring 15, a tip hole 16, a core 17, a tip seal 18, and a needle 19, but the multi-dose sterile administration dropper is not limited to the above-mentioned components, and may be a multi-dose sterile administration dropper currently available on the market, such as those available from Allergan corporation, or other commercial droppers.
The specific use method comprises the following steps: the A bottle can cap 1 is taken down, the B bottle bottom antibacterial plug 9 is taken down, the A bottle can with threads is aligned to the B bottle bottom with the built-in threads 10 and screwed down in a rotating mode, the B bottle bottom can be punctured by the inner needle 3 of the A bottle can with threads, the A bottle support handle 7 is pressed afterwards to push the piston shaft 6, the diluent contained in the A bottle empty cylinder 4 is pushed into the B bottle through the piston 5, the buckle 8 is clamped at the moment, and the piston shaft 6 can be prevented from falling off or flowing back. Shaking bottle B, dissolving bottle B powder, and making into eye drop; at this time, the dropper cap 20 of the B bottle multi-dose sterile administration dropper part 12 is removed, and the dropper 21 is passed through, and the solution can be dropped into the eye. After the dripping is finished, the dripping head cap 20 is covered. The screw that A bottle tank head was taken closely links up through the screw with B bottle built-in screw thread bottle end, and A bottle holds in the palm handle 7 and exists as the collet of whole drug delivery system promptly steadily.
Claims (9)
1. A multi-dose eye sterile powder delivery system comprises a liquid supply bottle A capable of containing diluent and an eye drop bottle B capable of containing solid powder and provided with a multi-dose sterile delivery dropper.
2. A sterile powder delivery system for multiple dose instillation according to claim 1, wherein said fluid supply bottle a is comprised of seven parts including a cap, a threaded can and inner needle, an empty cylinder, a plunger shaft, and a holder.
3. The sterile powder delivery system for multi-dose instillation according to claim 1, wherein the eye dropper bottle B is comprised of four parts, including a bottom stopper, a bottom with internal threads, a body, and a multi-dose sterile administration dropper.
4. The piston shaft of claim 2, with a retaining clip to prevent piston shaft dropout and backflow.
5. The threaded can and inner needle of claim 2, wherein the threads are adapted to engage a bottom of a B-bottle with internal threads, and the inner needle is adapted to puncture the bottom of the B-bottle protected by the anti-microbial stopper.
6. The multi-dose sterile administration dripper of claim 3, wherein the dripper has a dripper, a spring, a top seal, an air filter, and a tip hole.
7. The multi-dose sterile powder delivery system for ophthalmic use of claim 1, wherein the method of use comprises removing the cap of the can of the a bottle, removing the bottom of the bottle of the B bottle, screwing the threaded can of the a bottle against the bottom of the bottle of the B bottle with the built-in threads, puncturing the bottom of the bottle of the B bottle by the inner needle of the threaded can of the a bottle, pushing the holder of the a bottle to push the diluent contained in the a bottle into the B bottle, shaking the B bottle, and dissolving the powder in the B bottle to obtain the eye drops for therapeutic use; the external cover is removed when the eye drops are dropped, and the eye drop can be used. After the dripping is finished, the outer cover of the dripper is covered.
8. The sterile powder delivery system for multi-dose eyedrops according to claim 1, wherein said eyedrop bottle B contains solid powder which can be sterile packaged powder or powder obtained by lyophilization.
9. The sterile powder delivery system for multi-dose eyedrops according to claim 1, wherein the materials used for the eyedrop bottle A and the eyedrop bottle B are selected from polyethylene, polypropylene, polystyrene, polyethylene terephthalate, polyester, and the like, which are single materials or mixed materials thereof.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010421610.4A CN113679528A (en) | 2020-05-18 | 2020-05-18 | Multi-dose ophthalmic sterile powder delivery system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010421610.4A CN113679528A (en) | 2020-05-18 | 2020-05-18 | Multi-dose ophthalmic sterile powder delivery system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113679528A true CN113679528A (en) | 2021-11-23 |
Family
ID=78575644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010421610.4A Pending CN113679528A (en) | 2020-05-18 | 2020-05-18 | Multi-dose ophthalmic sterile powder delivery system |
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| Country | Link |
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| CN (1) | CN113679528A (en) |
Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1130356A (en) * | 1994-05-25 | 1996-09-04 | 加布里尔·迈耶尔 | Device for preparation of solution, suspension or emulsion of medical substance |
| US5569191A (en) * | 1992-12-15 | 1996-10-29 | Meyer; Gabriel | Device for preparing a medicinal substance solution, suspension or emulsion |
| CN2756245Y (en) * | 2004-10-08 | 2006-02-08 | 中山博泰药械有限公司 | Powder injection prefilling seal injector |
| CN200980825Y (en) * | 2006-08-17 | 2007-11-28 | 北京嘉林药业股份有限公司 | Solid-liquid separating integral eye medicine bottle |
| CN201200607Y (en) * | 2008-05-25 | 2009-03-04 | 王延飒 | Rinser for lacrimal passage |
| JP2009045140A (en) * | 2007-08-16 | 2009-03-05 | Ajinomoto Co Inc | Connecting structure of medicine vial and prefilled syringe, method for connecting medicine vial and prefilled syringe, medicine vial and combined kit formulation |
| CN102579185A (en) * | 2012-04-06 | 2012-07-18 | 成都华神生物技术有限责任公司 | Eye-drop device and application method thereof |
| JP2014079331A (en) * | 2012-10-15 | 2014-05-08 | Nipro Corp | Medicine/infusion mixture injection device |
| US20180168929A1 (en) * | 2016-12-21 | 2018-06-21 | Jason Stone | Vial with intergrated needless access port |
| CN208259833U (en) * | 2017-11-28 | 2018-12-21 | 武汉爱尔眼科医院有限公司 | A kind of Portable ophthalmic dropper |
| CN208405067U (en) * | 2017-07-07 | 2019-01-22 | 郑州大学第一附属医院 | A kind of ophthalmic nursing eye drop device |
| CN208464417U (en) * | 2017-07-21 | 2019-02-05 | 青岛科技大学 | Instant mixed type eye-drop liquid bottle |
| CN209220668U (en) * | 2017-03-31 | 2019-08-09 | 北京恒峰铭成生物科技有限公司 | Pigment separate type eye-drop liquid bottle |
-
2020
- 2020-05-18 CN CN202010421610.4A patent/CN113679528A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5569191A (en) * | 1992-12-15 | 1996-10-29 | Meyer; Gabriel | Device for preparing a medicinal substance solution, suspension or emulsion |
| CN1130356A (en) * | 1994-05-25 | 1996-09-04 | 加布里尔·迈耶尔 | Device for preparation of solution, suspension or emulsion of medical substance |
| CN2756245Y (en) * | 2004-10-08 | 2006-02-08 | 中山博泰药械有限公司 | Powder injection prefilling seal injector |
| CN200980825Y (en) * | 2006-08-17 | 2007-11-28 | 北京嘉林药业股份有限公司 | Solid-liquid separating integral eye medicine bottle |
| JP2009045140A (en) * | 2007-08-16 | 2009-03-05 | Ajinomoto Co Inc | Connecting structure of medicine vial and prefilled syringe, method for connecting medicine vial and prefilled syringe, medicine vial and combined kit formulation |
| CN201200607Y (en) * | 2008-05-25 | 2009-03-04 | 王延飒 | Rinser for lacrimal passage |
| CN102579185A (en) * | 2012-04-06 | 2012-07-18 | 成都华神生物技术有限责任公司 | Eye-drop device and application method thereof |
| JP2014079331A (en) * | 2012-10-15 | 2014-05-08 | Nipro Corp | Medicine/infusion mixture injection device |
| US20180168929A1 (en) * | 2016-12-21 | 2018-06-21 | Jason Stone | Vial with intergrated needless access port |
| CN209220668U (en) * | 2017-03-31 | 2019-08-09 | 北京恒峰铭成生物科技有限公司 | Pigment separate type eye-drop liquid bottle |
| CN208405067U (en) * | 2017-07-07 | 2019-01-22 | 郑州大学第一附属医院 | A kind of ophthalmic nursing eye drop device |
| CN208464417U (en) * | 2017-07-21 | 2019-02-05 | 青岛科技大学 | Instant mixed type eye-drop liquid bottle |
| CN208259833U (en) * | 2017-11-28 | 2018-12-21 | 武汉爱尔眼科医院有限公司 | A kind of Portable ophthalmic dropper |
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