JP2001502938A - Syringe system containing two separate prefilled barrels - Google Patents

Abstract

(57) Summary A pre-filled two-component system includes first and second containers or barrels. The first barrel includes a first chamber having a dispensing or delivery end. The delivery end defines a dispensing passage or delivery passage communicating through the delivery end and dispenses liquid from the first chamber. A removable seal or reciprocating stopper is slidably disposed in the first chamber, and a first component is disposed between the delivery end of the first chamber and the stopper. The second container or barrel is sized to be accommodated in the first barrel, has a discharge end defining a discharge passage communicating through the discharge end, and discharges liquid from the second barrel. A plunger is slidably disposed inside the second barrel. A second liquid component is disposed between the discharge end of the second barrel and the plunger. The stopper of the first barrel and the discharge end of the second barrel can be directly or indirectly engageable to transfer the second liquid component as the second barrel moves outward relative to the first chamber. The joint cooperatively defines an inflow from the second barrel to the first chamber of the first barrel.

Description

DETAILED DESCRIPTION OF THE INVENTION Syringe system containing two separate prefilled barrels This application is a continuation-in-part of U.S. patent application Ser. No. 08 / 408,463 filed Mar. 22, 1995. TECHNICAL FIELD OF THE INVENTION The present invention relates to a syringe system for packaging, mixing and delivering two components that must be stored separately from each other and must be combined or mixed before delivery. The present invention is particularly suitable for use in medicaments, such as medicaments in powder form, which must be dissolved and diluted in a liquid before delivery. Background of the Invention and Technical Problems of the Prior Art For medical, industrial or other applications, it may be necessary or at least desirable to separate the two components until they are combined for later delivery as a solution, mixture or other combination. For example, pharmaceutical preparations such as injection solutions and drug suspensions are not stable enough to withstand long-term storage until use. However, if the components of the solution or suspension are stored separately until compounding, sufficient stability may be obtained. It would be desirable if an improved syringe system could be provided that packaged such two components separately from each other and later operated to mix or mix the components upon delivery. In particular, it would be advantageous to provide such an improved syringe system that allows the use of pre-filled barrels that can be manufactured and / or stored separately and together as needed. It would be particularly advantageous if such an improvement system could be utilized with two liquid components and at least one solid component. It would be desirable if such a system could reliably seal the two components from the surrounding atmosphere and from each other. Further, it would be advantageous to provide such an improved system in a self-contained form that is small, portable, easy to handle, and readily available in various proportions and doses of components. It also requires reconstitution and / or dilution, especially of powdered pharmaceuticals that need to be mixed with diluents, liquid pharmaceuticals that need to be mixed with diluents, and lyophilized compounds that need to be mixed with diluents It would be desirable if such an improved system could be readily used for storage, mixing and administration of various drugs. The present invention provides improved packaging, mixing and delivery systems that include aspects having the above advantages and features. Summary of the Invention The present invention provides a syringe system for storing two components separately from each other. The system can then be operated to blend or mix the two components and then deliver the mixture. The syringe system includes first and second filled containers each including first and second filled syringe barrels, respectively. The first barrel includes an open end and an opposing, substantially closed delivery end. The delivery end defines a delivery or distribution passage for delivering or dispensing a liquid from the first barrel. Preferably, a first removable closure is positioned to block the delivery passage. A reciprocating stopper or movable seal is slidably disposed on the first barrel to define a first chamber. The first chamber is preferably filled with a first component between the reciprocating stopper and the delivery end. The second barrel is sized to be received in the first barrel and has an open end and an opposite substantially closed discharge end with a discharge passage for discharging liquid from the second barrel. Preferably, a second removable closure is arranged to block the discharge passage. A slidable plunger is hermetically disposed inside the second barrel to define a second chamber. The second barrel preferably has a second chamber filled with a second component between the discharge end and the slidable plunger. In order to mix the two components, when placing a second closure, the closure is first removed from the discharge end of the second barrel. The reciprocating stopper of the first barrel and the discharge end of the second barrel cooperatively define a coupling or liquid transfer connector means for flowing a second liquid component from the second chamber into the first chamber. Can be engaged. This includes (a) connecting means for connecting the second barrel to the reciprocating stopper of the first barrel, and (b) liquid for establishing liquid communication between the first chamber and the second chamber. Obtained by communication means. As the discharge end of the second barrel and the plunger move closer to each other, the liquid component is moved (ie, propelled) from the second chamber to the first chamber and the second liquid component is moved to the first chamber. Mix with ingredients. The assembly may be shaken to facilitate mixing. Next, the first closure is removed from the first barrel. Next, the second barrel engaged with the reciprocating stopper may be pushed inward. Due to this movement, the second barrel and the reciprocating stopper connected thereto move inward to the first chamber. With this coordinated movement, the mixed content of the first chamber is distributed through the delivery passage. Numerous other advantages and features of the present invention will be readily apparent from the following detailed description of the invention, the appended claims, and the accompanying drawings. BRIEF DESCRIPTION OF THE FIGURES BRIEF DESCRIPTION OF THE DRAWINGS The accompanying drawings form a part of the specification, and like reference numerals are used for similar parts throughout the drawings. FIG. 1 is a partial cross-sectional view of the first embodiment of the syringe system of the present invention showing the first and second containers before connecting the container barrels to one another. FIG. 2 is an enlarged partial cross-sectional view of the discharge end of the second barrel. FIG. 3 is an illustration of the components of FIG. 1 in a coupled state with the puncture needle of the second barrel pierced through the reciprocating stopper of the first barrel just before moving the plunger of the second barrel toward the discharge end. . FIG. 4 is a view similar to FIG. 3 showing a state in which the liquid content of the second barrel has been completely discharged into the first barrel. FIG. 5 is an enlarged partial cross-sectional view of the delivery end of the first barrel with the first closure removed and a needle attached. FIG. 6 is a cross-sectional view of the second embodiment of the present invention showing the separated first and second barrels of the container before they are joined together. FIG. 7 is an enlarged partial cross-sectional view of the conduit assembly and the reciprocating stopper in the first barrel of the second embodiment. FIG. 8 is a perspective view of a valve member used in the reciprocating stopper according to the second embodiment. FIG. 9 is a plan view of the valve member shown in FIG. FIG. 10 is a view similar to FIG. 7 showing a third embodiment of the present invention having a modified reciprocating stopper. FIG. 10A is a partial bottom view in the 10A-10A plane of FIG. FIG. 11 is a cross-sectional view of the fourth embodiment of the present invention showing the separated first and second barrels of the container before they are joined together. FIG. 12 is an enlarged partial cross-sectional view of a portion of the component after coupling of the fourth aspect showing the operation of the second barrel to open the mixing valve of the first barrel. FIG. 13 is a cross-sectional view of the fifth embodiment of the present invention showing the separated first and second barrels of the container before coupling. FIG. 14 is an enlarged partial cross-sectional view of a portion of the combined components of the fifth aspect showing the second barrel operated to open the mixing valve of the first barrel. FIG. 15 is a cross-sectional view taken substantially along the plane 15-15 of FIG. FIG. 16 is a cross-sectional view taken substantially along the line 16-16 of FIG. FIG. 17 is an enlarged partial cross-sectional view of a portion of the combined components of the sixth aspect of the present invention showing the operation of the second barrel to open the mixing valve of the first barrel. Description of the preferred embodiment Although the present invention is capable of many different forms of embodiment, The specification and the accompanying drawings disclose only certain specific embodiments as examples of the invention. But, The invention is not limited to the embodiments specifically described. The scope of the invention is set forth in the appended claims. The drawings showing the device are: Also known mechanical elements obvious to a person skilled in the art are shown. Since a detailed description of such elements is not necessary for an understanding of the present invention, Only the degree required to facilitate an understanding of the novel features of the invention is set forth herein. 1 to 5 show a first embodiment of a pre-filled syringe system of the present invention, The whole is designated by reference numeral 20. The system is generally It can be characterized as including two “containers” for separating the two components from each other and storing them separately so that they can be manipulated for later compounding or mixing and delivery. The first container has an open end 24, It includes a first barrel 22 having a substantially closed opposing dispensing or delivery end 26 defining a delivery or dispensing passage 28. The first barrel 22 is preferably manufactured from a synthetic polymer such as a thermoplastic material, The barrel may be manufactured from other suitable materials such as glass. The first barrel 22 contains a first component 40. Component 40 is a preferred embodiment for medical use, Granule form, It can be a drug or other medicament in powder form or other granular form. The first component may be a liquid. Component 40 in first barrel 22 is generally assumed to be a drug, Reconstitution is required for the solid form, Dilution is required in liquid form. Therefore, The system of the present invention is useful for encapsulating dangerous drugs such as those used in cancer research or biotechnology delivery applications. Preferably, Delivery end 26 receives a threaded cap or first removable closure 32; If you later remove the closure 32, An external thread 30 is provided for receiving a suitable dispensing component, such as a hollow needle 34, which will be described in greater detail with respect to FIG. Any other suitable conventional or special capping system can also be used. A reciprocating stopper 42 is slidably disposed on the first component 40 in the first chamber 24. The reciprocating stopper 42 is preferably manufactured from an elastic elastomeric material. In a preferred form, The reciprocating stopper 42 has an uncompressed diameter slightly larger than the diameter of the chamber 24. Normal packaging, A sufficient friction fit engagement is set between the stopper 42 and the chamber 24 to secure the stopper 42 on top of the component 40 during transport and handling. However, The engagement force is As will be described in detail later, when the stopper 42 receives a sufficiently high axial force, The value is low enough so that the stopper 42 can slide along the chamber 24. The reciprocating stopper 42 is a movable seal, Sliding seal, It can also be called a piston or grommet. All of these terms can be considered synonymous herein. The parent patent application 08/408, No. 463 uses the term "movable seal". But, The term "reciprocating stopper" is generally used herein to represent the same or similar components. As shown in FIG. It is also preferred to arrange the outer cover 44 on the upper open end of the first container barrel 22. This can prevent intrusion of contaminants. Cover 44 may be an adhesive soft web that can be easily peeled off immediately before use of the system. The first barrel 22 is a closure 32, Storing the first component 40 in cooperation with the stopper 42 and the cover 44; afterwards, The first component 40 can be considered as a first container for mixing with another component as detailed below. Inside the second barrel 48 is sealed a second component 46 in liquid form. Liquid component 46 is generally a diluent for diluting and / or reconstituting first component 40. The second barrel 48 can be formed from the same synthetic polymer material used for the first container 22. The second barrel 48 preferably includes a generally cylindrical wall portion 50 sized to fit in the first container 22 (FIGS. 3 and 4). In the initial state before combining, Preferably, the second barrel 48 is housed in a protective sleeve 52 that must be removed before use. Second barrel 48 further includes a plunger assembly or plunger 64 slidably disposed within cylindrical barrel 50. The plunger 64 is With a push flange at one end, It includes a plunger shank or stem 70 with a piston at the other end slidably received inside barrel cylindrical wall portion 50. Piston 68 is preferably an elastomer, As shown in FIG. 1, an initial arrangement is made at the upper end of the second barrel 48 in a state of contact with the second liquid component 46. For packaging convenience, Forming a threaded or snap-fit end 72 on the plunger shank 70; The top of the piston 68 may be engaged with a screw or snap fit. With such a structure, System components can be packaged without connecting or coupling the plunger shank 70 with the piston 68 from the outset. Later, when you need to use the system, The user can thread or snap the shank 70 onto the piston 68. The second barrel 48 has a discharge end 56 that defines a discharge passage communicating therewith for discharging liquid from the barrel 48. In the first embodiment shown in FIGS. The discharge passage of the second barrel is defined by the hollow interior of the puncture needle 60 attached to the discharge end of the second barrel 48. Preferably, The second barrel 48 is only provided to the user with a second cap or removable closure 62 attached to the puncture needle 60 at the discharge end 56 of the second barrel as shown in FIG. . The second closure 62 may be a snap fit or other means; For example, it can be fixed to the discharge end of the second container by screw engagement (not shown). The second barrel 48 As will be detailed later, Cooperating with the closure 62 and the plunger 64 to store the second liquid component 46; afterwards, It can be considered as a second container that functions as a syringe for discharging the second liquid component 46 into the barrel 22 of the first container. next, The operation of the packaging syringe system 20 will be described with respect to the continuous operation stages shown in FIGS. The first stage of the operation is shown in FIG. Just before use, remove the second closure 62, The puncture needle 60 is exposed. Before removing the second closure 62, Preferably, the second barrel 48 is overturned (so that the puncture needle 60 is substantially up). In this case, The liquid component 46 can be prevented from dripping. But, Even if the second barrel 48 does not fall, The liquid component 46 does not drip. This is because the second barrel 48 has no vent system. If a vent system is present, Since the ambient air flows into the second barrel 48, The liquid component simply flows out through the needle 60 under the effect of gravity. In the absence of such a vent, The liquid component 46 stays in the second barrel 48, It cannot flow out through the puncture needle 60. Preferably, the second barrel 60 is overturned so that the puncture needle 60 faces upward, The first barrel 22 is turned over and aligned with the second barrel 48. afterwards, The second barrel 48 is relatively moved so that the far end thereof is located within the first barrel 22. As shown in FIG. The second barrel 48 is inserted into the first barrel 22 until the puncture needle 60 engages with the reciprocating stopper 42 of the first barrel 22 and passes completely therethrough. Before or during the step of inserting the second barrel 48 inside the first barrel 22, The movable plunger 64 is not moved relative to the second container 48. The plunger 64 stops at the outermost initial position. After the puncture needle 60 is completely penetrated through the stopper 42 of the first barrel 22 and the two barrels are nested, The plunger 64 is pushed inwardly into the second barrel 48 (i.e., toward the discharge passage of the needle 60 of the second barrel 48). When the plunger moves, The second liquid component 46 flows out through the hollow puncture needle 60, Mix with the first component 40 inside the first chamber 24. The hydraulic pressure inside the first chamber 24 acts on the contact far end of the stopper 42 and the second barrel 48. When the pressure rises, The reciprocating stopper 42 and the second barrel 48 are moved outward (ie, propelled) with respect to the first barrel 22. Ambient atmospheric pressure is applied to the outer surface of the plunger piston 68, It will be appreciated that this additional pressure is effective to facilitate the discharge of the second liquid component 46 into the first chamber 24. When the piston 68 reaches the bottom discharge end of the second barrel 48, The top open end of the second barrel 48 is adjacent to the top push flange of the plunger 64 (see FIG. 4). Substantially the entire amount of the second liquid component is discharged through the hollow puncture needle 60 into the first chamber 24 of the first barrel 22; Forming a solution with the first component 40, Mixed or otherwise compounded. The assembly may be shaken to ensure good mixing. After thoroughly mixing the ingredients, When the first closure 32 is removed from the first barrel 22, The delivery end 26 can be connected to a receiving or draining component (not shown), such as a flexible container or tubing. In some cases, A hollow needle 34 may be attached to the distal end of the delivery end 26 of the first barrel. Needle 34 may be of the conventional single-ended type having a straight hollow stainless steel shaft, typically of 20 gauge size. The needle 34 may be formed with a swaged or molded hub 74 (FIG. 5) for engaging the bottom distal end of the delivery end 26 of the first barrel 22. When properly attached to the first barrel 22, Needle 34 is aligned with delivery passage 28, Liquid communication is established between the delivery passage 28 and the needle 34. After properly attaching the needle 34 to the first barrel 22 (or after properly connecting the first barrel 22 to some other suitable receiving component), The application of the axial force allows the plunger 64 and the second barrel 48 to move forward. As a result, The components mixed in the first chamber 24 are dispensed or discharged from the chamber 24 through the needle 34. It will be appreciated that the first barrel stop 42 has a central portion that allows the needle 60 to pass completely therethrough. The central portion of the stopper and the puncture needle 60 of the second barrel cooperate to define a liquid transfer connector or coupling means including (a) liquid communication means and (b) coupling means. The liquid communication means includes a flow path inside the needle 60 operable to cause a second liquid component to flow from the second barrel 48 to the first chamber 24 of the first barrel 22. The coupling means includes an airtight engagement between the outside of the needle 60 and the stopper 42, First, move the stopper 42 and the second barrel 48 outward, When the second liquid component 46 is moved (ie, pressed or propelled) into the first chamber 24, afterwards, Move inward into the first chamber 24, Dispense the mixed ingredients. A second embodiment of the syringe system of the present invention is shown in FIGS. In this embodiment, the elements that are identical or function similarly to the elements of the first embodiment shown in FIGS. The two-digit reference number of the corresponding element of the first embodiment and the last two digits are indicated by the same three-digit reference number. In FIG. A second aspect of the syringe system includes a first barrel 122 and a second barrel 148. The first barrel 122 has an open top that is initially sealed with a removable cover 144. The first barrel 122 has a first component: Contains component 140. The first component 140 is Located at the bottom of the first barrel 122 defining a dispensing end or delivery end 126 having a dispensing or delivery passage 128 communicating through the dispensing or delivery end 126 to dispense liquid from the first chamber 124. You. The closed delivery end 126 is preferably 6, including a concentrically extending collar formed with an internal thread for receiving the first removable closure 132. As shown in FIG. When the closure 132 is removed, Delivery end 126 can be threaded with a suitable receiving component, such as a stopcock or IV management set (not shown). A reciprocating stopper 142 is slidably disposed on the first barrel 122, A first chamber 124 pre-filled with a first component 140 is defined with the first barrel 122. The stopper 142 is Normal save, Secured with sufficient frictional engagement to prevent movement inside the first barrel 122 during transport and handling. The reciprocating stopper 142 is a movable seal, Sliding seal, It can also be called a piston or grommet. All of these terms can be considered synonymous herein. The parent patent application 08/408, No. 463 uses the term "movable seal". But, The term "reciprocating stopper" is generally used herein to represent the same or similar components. The reciprocating stopper 142 is preferably manufactured from an elastic elastomeric material. In a preferred form, The reciprocating stopper 142 has an uncompressed diameter that is slightly larger than the diameter of the first barrel 122 to allow a friction fit sliding engagement with the first barrel 122. The reciprocating stopper 142 is Normal save, Secured with sufficient frictional engagement so that it cannot move with the first barrel 122 during transport and handling. As shown in FIG. Place the new conduit and valve assembly 176 on the reciprocating stopper 142. The conduit and valve assembly 176 includes Extends through the stopper 142, Includes a generally elongated conduit 177 (which may be in the form of a Luer socket) defining an internal flow passage 178 having an inlet 177A and an outlet 177B. The conduit and valve assembly 176 includes a laterally projecting boss 180 defining a receiving cavity 181 for receiving the ribbed anchor portion 184 of the valve member insert 185. Valve member insert 185 includes a laterally resilient spring member 186 extending from the lower end of anchor portion 184. A frustoconical flapper valve member 187 projects upward from the spring member 186. The outer surface of valve member 187 is configured to seal conduit outlet 177B. Spring member 186 generally comprises The valve member 187 is biased into an airtight engagement with the conduit outlet end 177B as shown in FIG. This defines a check valve. The inlet end of the conduit and valve assembly 176 Including a standard female threaded luer socket defining an inlet 177A; Extending is a connector flange 179 as used in conventional coupling systems commercially available under the trademark LUER-LOK. Thus, The conduit and valve assembly 176 may be connected to the second barrel 148 as described in more detail below. Other suitable conventional or special coupling systems may be used. The first barrel 122 is a closure 132, Reciprocating stopper 142, Cooperating with the conduit and valve assembly 176 and the cover 144 to store the first component 140; afterwards, It can be considered as a container for mixing. Preferably, the second barrel 148 initially includes a perimeter protective sleeve 152 for removal and disposal after use. The second barrel 148 preferably has a cylindrical barrel portion 150 containing a second liquid component 146 held inside the barrel portion 150 by a plunger assembly or plunger 164; The plunger has at one end a piston 168 slidably disposed inside the barrel portion 150; It has a push flange at the other end. The bottom end of second barrel 148 defines discharge end 156. End 156 defines an outer discharge passage 159 (preferably in the form of a standard Luer nozzle) that defines an internal discharge passage 159 communicating through discharge end 156 to discharge liquid from barrel portion 150 of second barrel 148. A conduit 158 is included. Conduit 158 allows fluid tight communication with a female luer socket defining an inlet 177A of conduit assembly 176 of first barrel 122. A collar 161 extends axially around the discharge conduit 158 at a predetermined interval. Collar 161 defines an internal thread of the type used in connection systems sold under the trademark LUER-LOK. Therefore, The collar 161 can be threadedly engaged with the threaded flange 179 at the inlet end of the conduit and valve assembly 176 projecting from the reciprocating stop 142 in the first barrel 122. The second barrel projecting conduit 158 is configured to insert into the inlet 177A of the conduit and valve assembly 176 to form a leaktight seal with the conduit 177. Therefore, A second barrel collar 161 and a conduit 158; The first barrel conduit and valve assembly 176 serves as a cooperating liquid transfer connector or coupling means for connecting the second barrel 148 with the first chamber 124 of the first barrel 122 via the reciprocating stopper 142. I do. Illustrated specific form of collar 161, Instead of conduit 158 and conduit and valve assembly 176, Other suitable connection structures may be used. A second removable closure member 162 in the form of a threaded plug threadedly engaged with the collar 161; It is preferable to remove it before use. In this case, Stop the ingress of contaminants, The second liquid component can be prevented from leaking from the second barrel 148. As a matter of course, When not using the removable closure 162, Since there is no vent system to allow ambient air to flow into the second barrel 148 and allow the liquid component 146 to flow out only under the effect of gravity, The second liquid component 146 does not leak from the small diameter passage 159. Second barrel 148 cooperates with closure member 162 and plunger 164 to retain second liquid component 146; afterwards, It can be considered as a second container or syringe for draining. To mix the two components, It is preferred to keep the two barrels in the overturned position. The closure 162 is removed from the second barrel 148. Inserting the second barrel 148 into the first barrel 122; The second barrel discharge conduit 158 is connected to the first barrel conduit assembly 176. The second barrel luer nozzle conduit 158 is inserted into the female luer socket inlet 177A of the first barrel conduit and valve assembly 176. next, The threads of the second barrel collar 161 engage the first barrel conduit and flange 179 of the valve assembly 176. Relative rotation of the two barrels, Fully threaded engagement. afterwards, The plunger 164 of the second barrel may be propelled toward the discharge passage 159. The second liquid component 146 flows from the second barrel 148 through the conduit and valve assembly 176 (with the valve member 187 open) into the first barrel 122, Reciprocating stopper 142 moves outwardly within first barrel 122 with second barrel 148 coupled to assembly 176. While ambient atmospheric pressure acts on the outer surface of plunger piston 168 and is transmitted to second liquid component 146, The first barrel 122 and the second barrel 148 may simply be pulled relatively outward. As the stopper 142 is pulled outward, the volume below the stopper 142 inside the first barrel chamber 124 increases, The pressure inside the chamber 124 decreases. As a result, The differential pressure causes the valve member 187 to open, Second liquid component 146 flows into first barrel 122 and mixes with first component 140. While the second liquid component 146 is being transferred to the first barrel 122, The relative outer movement of the two barrels 122 and 148 continues until the inner bottom surface of the plunger piston 168 engages the inner bottom surface of the second barrel 148. at this point, The second liquid component 146 is completely discharged from the barrel portion 150 of the second barrel 148 into the first barrel 122. The assembly may be shaken to ensure good mixing. afterwards, Removing the first closure 132 from the first barrel 122; Delivery end 126 may be connected to a suitable receiving component or drain (not shown). Or, A needle such as the needle 34 shown in the first embodiment in FIG. 5 may be mounted on the first barrel 122. next, Push the push flange of plunger 164, The second barrel 148 and the reciprocating stopper 142 connected thereto are further moved inward to the first barrel 122. Thus, The mixed components 140 and 146 are discharged from the first barrel 122. A first barrel conduit and valve assembly 176; The second barrel collar 161 and the second barrel conduit 158 cooperate to provide a liquid transfer connector means or a liquid connection in the form of a liquid connection that allows the second liquid component 146 to flow from the second barrel 148 into the first barrel 122. It will be appreciated that it defines a coupling means. The liquid transfer connector means or coupling means further comprises: The second barrel 148 can also be moved outward relative to the first barrel 122 while transferring the second liquid component 146 from the second barrel 148 to the first barrel 122. Furthermore, The liquid transfer connector means or coupling means is then The second barrel 148 may be moved inward while distributing the mixed components from the first chamber 124 of the first barrel 122. The unique liquid transfer connector means or coupling means used in the embodiment shown in FIGS. (1) liquid communication means; (2) It can be characterized as including cooperative connection means. "Liquid communication means" (A) a "first liquid connector", preferably in the form of a Luer-type socket or conduit 177, defining a flow path to the second barrel 122; (B) Includes a cooperating “second liquid connector” in the form of a Luer nozzle or conduit 158 that defines a flow path from the second barrel 148. "Collaborative connection means" There may be a friction fit connection between the Luer nozzle or conduit 158 and the Luer socket or conduit 177. However, The coupling means cooperate to set a screw connection, The second barrel collar 161 includes a screw, The conduit and valve assembly 176 of the first barrel 122 preferably includes a radial flange 179. A third embodiment of the invention, including a modified conduit and valve assembly, is shown in FIGS. 10 and 10A. This aspect is A reciprocating stopper 242 includes a first barrel 222 defining a first chamber 224 slidably disposed over a first component (not shown in FIGS. 10 and 10A). A conduit 277 is disposed on the reciprocating stopper 242, It extends through a reciprocating stopper 242. Conduit 277 defines an internal passage 278, It has an inlet 277A and an outlet 277B. At inlet 277A, conduit 277 defines a standard female luer socket, Extending is a connector flange 279, which may be the same as the flange 179 described above with respect to the embodiment shown in FIGS. The bottom of the reciprocating stopper 242 has a truncated cone shape 243, A partial slit 289 is formed at the outlet 277B of the conduit 277 so as to cross the frustoconical axis. This slit is The non-slit portion 290 (FIG. 10A) defines a flap or valve member 287 mounted on the body of the stopper 242. Portion 290 is elastic, Normally, the valve member 287 is biased upward so as to press the valve member 287 against the outlet 277B of the conduit 277 so as to block the passage 278. The stopper 242 and the conduit 277 shown in FIGS. The second embodiment shown in FIG. 6 is configured to cooperate with a second container or barrel (not shown), which may be the same as the second barrel 148 described above. The second barrel is inserted into the first barrel 222 as described above for the second barrel 148 and the first barrel 122 embodiment of the connection shown in FIG. It can be connected to a conduit 277. The operation of the embodiment of the system shown in FIGS. 10 and 10A for mixing and subsequent dispensing of the two components is identical to the operation of the second embodiment described above with respect to FIGS. A fourth embodiment of the syringe system is shown in FIGS. Many elements of the fourth aspect of the syringe system are identical or functionally similar to corresponding elements of the first aspect shown in FIGS. The elements of the fourth embodiment shown in FIGS. 11 and 12 are indicated by three-digit reference numbers from 300 to 399. The last two digits of the reference number of the fourth aspect of the element corresponding to the element of the first aspect, Identical to the last two digits of the reference number used to represent the corresponding element of the first aspect. In FIG. A fourth aspect of the syringe system includes a first barrel 322 having a first chamber 324 containing a first component 340. The lower portion of first barrel 322 includes a delivery or dispensing end 326 that defines a delivery or dispensing passage 328. The delivery passage 328 is preferably blocked by a first removable closure 332 that can be secured to the delivery end 326 by a friction fit. Snap-fit beads and grooves, Other coupling systems such as screws may be used. A stopper 342 is disposed in the first chamber 324 over the first component 340. Reciprocating stopper 342 (movable seal, The reciprocator has a lower end surface defining a conical shape 343 (which can also be characterized as a grommet or plunger piston). As shown in FIG. The apex of the cone has at least one slit 389 (or not shown, With two intersecting slits). A single slit 389 defines two lips or flaps 387. The two intersecting slits define four lips. The lip 387 is normally biased to a closed position as shown in FIG. The upper end of the reciprocating stopper 342 has a wide receiving cavity 393 and a narrow entrance passage 394, Together, they define a retaining shoulder 395. transport, The reciprocating stopper 342 is initially positioned in the first barrel 322 with sufficient frictional engagement to prevent movement of the stopper during storage and handling. First barrel 322 may be considered a first container for storing first component 340 in cooperation with reciprocating stopper 342 and closure 332. The reciprocating stopper 342 is configured to engage and move with a second barrel 348 that includes a cylindrical barrel portion 350 sized to be housed in the first barrel 322. Barrel portion 350 has a discharge end 356 that defines a discharge passage 359 that communicates through discharge end 356 to discharge liquid from barrel portion 350. The discharge end 356 has a wide head 396 and a narrow neck 393 (FIG. 11). Neck 398 and head 396 cooperate to define a lateral shoulder 399. Inside the barrel portion 350, below the plunger 364 with the piston 368, a second liquid component 346 is contained. In order to minimize the probability of entry of contaminants and the leakage probability of component 346, Preferably, a suitable closure 362 is removably attached to the discharge end 356. The closure 362 may be fixed to the discharge end 356 by friction fit, screw, It may be secured by other suitable conventional or special means such as snap-fit beads and grooves. The second barrel 348 cooperates with the closure 362 and the plunger 364 to hold and store the second liquid component 346; afterwards, It can be characterized as a second container or syringe for draining. Preferably, A protective sleeve (not shown) may be placed around the second barrel 348 in substantially the same manner as the sleeve 52 is placed around the second barrel 48 of the first embodiment shown in FIG. Good. Also, If desired A removable cover (not shown) may be attached to the first barrel 322, such as the cover 44 shown on top of the first barrel 22 of the first embodiment shown in FIG. To use the system shown in FIGS. 11 and 12, The closure 362 is removed from the second barrel 348. Next, the second barrel 348 is placed inside the first barrel 322. At this stage, It is preferred to do so by turning over the second barrel 348 before removing the closure 362. The first barrel 322 also falls, The two barrels are telescopically engaged in the overturned position. The second barrel 348 is pushed into the first barrel 322 until the second barrel head 396 has sufficiently expanded the seal inlet passage 394 into the seal receiving cavity 393. In this position, The dispensing end neck 398 of the second barrel Reciprocating stopper 342 is resiliently received in a narrow inlet passage 394 having a smaller diameter structure; The seal retaining flange 395 thus engages the flange 399 of the second container. Thus, separation of the second barrel 348 from the reciprocating stopper 342 of the first barrel is prevented. In the initial engagement position where the discharge end 356 of the second barrel is connected to the reciprocating stopper 342 of the first barrel, Stopper lip, Because the flap or valve member 387 is closed, The second liquid component does not mix into the first component 340. next, By pushing the plunger 364 of the second barrel to force the second liquid component 346 through the valve member 387 into the first chamber 324 of the first barrel, etc. The first and second barrels move relatively outward. Thus, the second barrel 348 is pulled out with respect to the first barrel 322. Or, The two barrels 322 and 348 may be separated. As a result of the ambient atmospheric pressure acting on the plunger 368, The second liquid component 346 in the second barrel 348 is maintained at ambient atmospheric pressure. As the volume of the first chamber 324 below the reciprocating stopper 342 increases, Negative differential pressure occurs, The second liquid component 346 urges the valve member 387 outward to the open position shown in FIG. Thus, the second liquid component 346 can flow into the first component 340. The two barrels move relatively outward until the bottom surface of plunger piston 368 engages the bottom of cylindrical barrel portion 350 of second barrel 348. at this point, The second liquid component 346 has been completely released into the first component 340 in the first chamber 324. afterwards, Valve lip 387 closes. The assembly may be shaken to ensure good mixing. Then The closure 332 is removed from the delivery end 326 of the first barrel. afterwards, The delivery end 326 of the first barrel may be connected to a receiving component or distribution tube (not shown) or a hypodermic needle (such as needle 34 described above for the first embodiment shown in FIGS. 1-5). afterwards, Push plunger 364 and second barrel 348 inward. Thus, the plunger piston 368 reaches the bottom of the cylindrical barrel portion 350 of the second barrel 348, The second barrel 348 and the reciprocating stopper 342 connected thereto move toward the bottom of the first container 322. As a result, The mixed components are dispensed from the first container 322. A fifth embodiment of the syringe system, including designs that may be preferred for some applications, is shown in FIGS. Many elements of the fifth aspect of the syringe system are identical or functionally similar to corresponding elements of the first to fourth aspects shown in FIGS. The elements of the fifth embodiment shown in FIGS. 13 to 16 are indicated by three-digit reference numbers from 400 to 499. The last two digits of the reference number of the fifth aspect of the element corresponding to the element of the first and fourth aspects are: The same as the last two digits of the reference number used to indicate the corresponding element of the first and fourth aspects. In FIG. A preferred form of the syringe system includes a first barrel 422 having a first chamber 424 containing a first component 440. The lower portion of the first barrel 422 includes a delivery or distribution end 426 that defines a delivery or distribution passage 428. The delivery passage 428 is preferably blocked by a first removable closure 432 that can be secured to the delivery end 426 with a threaded engagement. For this, The delivery end 426 of the first barrel includes a tapered luer component 433 surrounded by an annular collar 435 defining an internal female thread 436. Closure 432 includes a stem 437 that is received in delivery passage 428, It has an external flange or lug 438 for engaging the female screw 436. A reciprocating stopper 442 is disposed in the first chamber 424 over the first component 440. The reciprocating stopper 442 is a movable seal, It can also be called a grommet or plunger piston. Reciprocating stopper 442 has a lower end defining an inner or end surface 443 having a conical shape. The apex of the cone has one slit 489. The slit 489 is It defines two lips or flaps 487 that are normally biased to the closed position as shown in solid lines in FIG. The reciprocating stopper 442 has an outer or upper end surface 439. A wide receiving cavity 493 and a narrow entrance passage 494 are arranged between the stopper outer surface 439 and the stopper inner surface 443, Together, they define a retaining shoulder 495. transport, The reciprocating stopper 442 is initially positioned in the first barrel 422 with sufficient frictional engagement to prevent movement of the stopper during storage and handling. The reciprocating stopper 442 is configured to receive the support member 441. The support member 441 includes a flow path 445, It defines a communicating luer socket 444 capable of receiving a luer nozzle (as described below). The support member 441 has a wide head 496 and a narrow neck 498 (FIG. 14). Neck 498 and head 496 cooperate to define a lateral shoulder 499. The support member 441 is The support member head 496 can be pushed fully into the resilient reciprocating stopper 442 until the seal inlet passage 494 is sufficiently widened and enters the seal receiving cavity 493. In this position, The neck 498 of the support member is Reciprocating stopper 442 is resiliently received in a narrow inlet passage 494 having a smaller diameter structure; Thus, the reciprocating stopper holding flange 495 is engaged with the shoulder 499 of the support member. Therefore, The support member 441 cannot be separated from the reciprocating stopper 442 of the first barrel. Preferably, member 441 further has a support flange 457 (FIG. 14). In this case, It is possible to prevent the reciprocating stopper 442 from being deformed to the extent that leakage occurs. The first barrel 422 has a reciprocating stopper 442, Cooperating with support member 441 and closure 432 to store first component 440, afterwards, It can be characterized as a first container for mixing with a second liquid component 446 contained in a second barrel 448 (FIG. 13). In FIG. The second liquid component 446 is contained inside the cylindrical barrel portion 450 of the second barrel 448 under a plunger 464 having a piston 468. Barrel 448 has a discharge lower end 456 defining a discharge passage 459. The discharge end 456 preferably has the structure of a Luer nozzle that is received in a Luer socket 444 of the support member 441. In order to minimize the probability of entry of contaminants and minimize the probability of leakage of component 446, Preferably, a suitable closure 462 is removably attached to the discharge end 456. The closure 462 may be fixed to the discharge end 456 by friction fit, screw, It may be secured by other suitable conventional or special means such as snap-fit beads and grooves. Second barrel 448 cooperates with closure 462 and plunger 464 to store second liquid component 446; afterwards, It can be characterized as a second container or syringe for draining. It is preferred to place a protective sleeve (not shown) around the second barrel 448 substantially in the same way as the sleeve 52 is placed around the second barrel 48 of the first embodiment shown in FIG. . Also, If desired A removable cover (not shown) may be attached to the first barrel 422, such as the cover 44 shown on top of the first barrel 22 of the first embodiment shown in FIG. In order to use the system shown in FIGS. Remove cap 462 from second barrel 448. Next, the second barrel 448 is placed inside the first barrel 422. At this stage, Before removing the closure 462, it is preferable to first perform the overturning of the second barrel 448. The first barrel 422 also falls, The two barrels are telescopically engaged in the overturned position. The luer nozzle at the discharge end 456 of the second barrel 448 is located inside the luer socket 444 of the support member 441. This may be a friction fit connection. Or, As described below with respect to the sixth embodiment shown in FIG. A more secure mechanical connection may be used. In the initial position where the discharge end 456 of the second barrel is attached to the reciprocating stopper 442 of the first barrel via the member 441, Stopper flap, Because the lip or valve member 487 is closed, The second liquid component does not mix with the first component 440. When you push the plunger 464, The second liquid component 446 can be discharged to the first chamber 424 of the first barrel 422 through the slit 489 of the reciprocating stopper. As the second component 446 flows into the first barrel chamber 424, The reciprocating stopper 442 and the second barrel 448 move outward. Or, The first and second barrels 442 and 448 may be drawn relatively outward. As a result of the ambient atmospheric pressure acting on the plunger piston 468, The second liquid component 446 is maintained at ambient atmospheric pressure. As the volume of the first chamber 424 below the reciprocating stopper 442 increases, Negative differential pressure occurs, The second liquid component 446 urges the stopper lip or valve member 487 outward to the open position shown in FIG. Thus, the second liquid component 446 can flow into the first component 440. The two barrels 422 and 448 move relatively outward until the bottom surface of the plunger piston 468 engages the bottom of the cylindrical barrel portion 450 of the second barrel 448. at this point, The second liquid component 446 has been completely released into the first component 440 in the first chamber 424. afterwards, Valve flap 487 closes. The assembly may be shaken to ensure good mixing. Then The closure 432 is removed from the delivery end 426 of the first barrel. afterwards, The delivery end 426 of the first barrel may be connected to a receiving component or distribution tube (not shown) or a hypodermic needle (such as needle 34 described above for the first embodiment shown in FIGS. 1-5). afterwards, Push plunger 464 inward. Thus, piston 468 reaches the bottom of cylindrical barrel portion 450 of second barrel 448, A second barrel 422, The support member 441 and the connected reciprocating stopper 442 move toward the bottom of the first container 422. As a result, The mixed components are dispensed from the first container 422. FIG. 17 shows a sixth embodiment of the present invention. The sixth embodiment is a modification of the fifth embodiment described above with reference to FIGS. In particular, The sixth embodiment includes a support member 441A substantially similar to the support member 441 of the fifth embodiment. However, The support member 441A includes an inwardly extending skirt 451A with internal female threads 453A. The second barrel 448A has substantially the same structure as the second barrel 448 of the fifth embodiment, The second barrel 448A of the sixth aspect has a radial lug for threaded engagement with the support member screw 453A. Includes flange or screw 455A. For this reason, A secure mechanical connection is provided between the second barrel 448A and the support member 441A. The fourth shown in FIGS. In each of the fifth and sixth aspects, Preferably, a gap is provided between the end of the head 496 of the support member 441 and the closed stopper valve lip or flap (eg, 487 in FIG. 16) when the stopper lip or flap is closed. In this case, The stopper can flex properly within the range required to close the slit. The embodiment shown in FIGS. It can be characterized using a unique liquid transfer connector means or coupling means. The liquid transfer connector means or coupling means comprises: (1) liquid communication means; (2) It can be characterized as including cooperative connection means. In the embodiments shown in FIGS. 11 and 12, The liquid connection means comprises a first liquid connector in the form of a passage 359 at the discharge end 356 of the second barrel; Includes a second liquid connector in the form of a flow path through the reciprocating stopper 342 and the stopper flap or lip 387. The cooperative coupling means includes a wide head 396 of the second barrel 348, Includes cooperating stopper receiving cavity 393 and retaining shoulder 395. In the embodiment shown in FIGS. The liquid communication means includes a flow path passing through the reciprocating stopper 442, A first liquid connector in the form of a Luer-type socket or conduit 444 (FIG. 14) defining a flow path in the support member 441; A second cooperating liquid connector in the form of a Luer nozzle 456 defining a flow path in the second barrel. The collaborative connection means Simply luer fitting the luer nozzle 456 to the luer socket 444; The support member 441 and the stopper 442 may be engaged. But, As shown in FIG. The connecting means further includes a screw 453A on the support member 441A, A second barrel 448A including a radial flange 454A; It is preferable to set the screw connection in cooperation. In all aspects of the figures, It will be appreciated that the dispensing or delivery end of the first barrel is sealed with a removable closure (eg, the dispensing end closure 32 of the first container). The discharge end of the second barrel may include a closure (ie, closure 62 shown in FIG. 1). Furthermore, When using such a closure, Screw-fitting elastomer seal member, Soft adhesive sealing member, Alternative forms such as shrink wrap film or other closure systems may be used. The syringe system of the present invention provides an advantageous means of co-dispensing two components that must be separated from each other until use in mixing. The system is self-contained and sealed. This system can be used to reconstitute or dilute the drug at the bedside when the drug is needed. This system adapts to any diluent compatible with the construction material used, The choice of diluent is not limited. The system of the present invention can store the components in a form that maximizes the stability of the components. As we use reconstituted product immediately, No refrigeration or other storage methods are required as required for some reconstituted products. As is obvious from the detailed description of the invention and the drawings, Many modifications and variations are possible without departing from the true spirit and scope of the novel concept or principle of the present invention.

────────────────────────────────────────────────── ─── Continuation of front page    (72) Inventor Hofstetter, Jillon M             United States, Illinois 60061, Bar             Non Hills, Stockkton Court             1001 (72) Inventors O'Neill, Ji Young A             United States, Illinois 60060, Man             Delane, South Emerald Avenille             ー ・ 58

Claims (1)

[Claims] 1. A first barrel having an open end and an opposing delivery end defining a delivery passage; A first chamber for receiving a first component between the delivery passage and the reciprocating stopper; A reciprocating stopper air-tightly arranged in said first barrel to define a bar; Sized to be accommodated in the first barrel, and having an open end and an opposite end defining a discharge passage. A second barrel having a side discharge end; A second liquid component for containing a second liquid component between the discharge passage and the sliding plunger; A sliding plate hermetically arranged inside the second barrel so as to define a chamber; The langers, When moving the discharge end of the second barrel and the plunger so as to approach each other; The second barrel is operatively connected to the reciprocating stopper, and the stopper is Passing the second liquid component from the second chamber into the first chamber. Flows in and mixes with the first component, after which the second barrel and reciprocating stopper Moving together towards the delivery passage of the first barrel, the delivery passage From the first chamber through Syringe mix including liquid transfer connector means configured to release the mix component Coupling and delivery system. 2. The liquid transfer connector means, (1) A hollow puncture needle arranged in the second barrel so as to communicate with the discharge passage When, (2) Part of the reciprocating stopper capable of completely penetrating the puncture needle The system of claim 1 comprising: 3. The liquid connector means, (1) a conduit extending through the reciprocating stopper and having an inlet end and an outlet end; (2) The reciprocating stopper is disposed adjacent to the outlet end of the conduit, and A flapper valve member biased to a normally closed position blocking the conduit outlet of the tube; (3) a flange disposed at the inlet end of the conduit; (4) the flange so as to establish liquid communication between the discharge passage and the conduit; 2. The screw of claim 1, including a screw disposed in the second barrel for threading engagement with the second barrel. System. 4. The liquid transfer connector means, (1) It is defined in the reciprocating stopper and is normally biased to the closed position. Resiliently opened and open to the first chamber towards the delivery passage An elastic portion having at least one longitudinal through slit defining a lip; (2) At one end of the wide cavity to define a retaining shoulder around the narrow entrance passage A wide receiving member disposed on the elastic portion of the reciprocating stopper adjacent to the elastic lip. A cavity and a narrow entrance located at the reciprocating stopper to open into the wide cavity Aisle and (3) the discharge passage of the second barrel is normally the biased closure of the reciprocating stopper In the wide receiving cavity of the reciprocating stopper so as to be blocked by the elastic lip A wide head positioned in the discharge passage of the second barrel to be received; The second barrel is adapted to be received in the inlet passage of the reciprocating stopper; The system of claim 1 including a narrow neck disposed in the discharge passage. 5. The liquid transfer connector means (a) connects the second barrel to the reciprocating stopper; Connecting means for connecting the second chamber through the stopper; Liquid communication means for flowing the second liquid component from the chamber into the first chamber Comprising, the liquid distribution means, A first liquid connector interlocked with the reciprocating stopper in the first barrel; A second cooperating liquid connector operatively associated with the discharge passage of the second barrel; A normally closed check valve, wherein the first fluid connector is connected to the first 2. The system of claim 1, including a liquid passage to the chamber. 6. Said liquid passage is defined at least partially through said reciprocating stopper; The system of claim 5, wherein the check valve is integral with the reciprocating stopper. 7. The reciprocating switch so that the first liquid connector is in liquid communication with the check valve. A luer socket disposed on the topper, wherein the second liquid connector is A luer nozzle in the discharge passage of the second barrel, A screw formed in the second barrel near the luer nozzle; A radial flange formed on the luer socket; The second barrel so that a nozzle connects the luer nozzle to the luer socket. 7. The system of claim 6, wherein the system is threadably engageable with a screw of the screw. 8. A luer socket in which the first liquid connector is in liquid communication with the liquid passage; Support member with The second cooperating liquid connector in liquid communication with a luer socket of the support member; A luer nozzle located at the discharge end of the second barrel so as to be located at Yes, The connecting means is provided in the second barrel disposed in a luer socket of the support member; The system of claim 5 including a luer nozzle friction fit. 9. The coupling means is defined in the support member near the luer socket A screw, formed in the second barrel for threading engagement with a screw of the support member. 9. The system of claim 8, further comprising a radial flange. 10. The plunger is detachable from the sliding piston and the sliding piston Including the attached shank, The system further comprises: A first removable closure blocking the delivery passage of the first barrel; A second removable closure blocking an outlet passage of the second barrel; Removably mounted on the open end of the first barrel opposite the delivery passage 2. The system of claim 1, including a flared cover. 11. The first component and the second liquid component are stored separately, and then the components are mixed A pre-filled syringe system for dispensing the mixture A first barrel having an open end and an opposing delivery end defining a delivery passage; A first removable closure that hermetically blocks the delivery passage; A first chamber for receiving a first component between the delivery passage and the reciprocating stopper; A reciprocating stopper air-tightly arranged in said first barrel to define a bar; Sized to be accommodated in the first barrel, and having an open end and an opposite end defining a discharge passage. A second barrel having a side discharge end; A second removable closure blocking the discharge passage; A second liquid component for containing a second liquid component between the discharge passage and the sliding plunger; A sliding plate hermetically arranged inside the second barrel so as to define a chamber; The langers, When the second barrel is nested at the open end of the first barrel The second barrel is operatively connected to the reciprocating stopper, and the second barrel is connected to the second barrel. The stopper is moved by moving the discharge end and the plunger closer to each other. The second liquid component from the second chamber to the first chamber through the second chamber. And mixes with the first component, and then reciprocates with the second barrel. Moving the pars together toward the delivery passage of the first barrel, A knot configured to release the mixed component from the first chamber through a passage; The system comprising combining means. 12. The coupling means, (1) discharging said second barrel so as to be in fluid communication with said second chamber; A hollow puncture needle arranged in the passage, (2) the second removable closure from the discharge passage of the second barrel; When the needle is removed, the puncture needle can be completely penetrated and 12. The pre-filled syringe system of claim 11, including a portion of said reciprocating stopper. 13. The coupling means, (1) Liquid from the second chamber to the first chamber Liquid communication means for communicating (2) Including a connecting means for connecting the second barrel to the reciprocating stopper. A pre-filled syringe system according to claim 11. 14． The liquid communication means, (1) a conduit extending through the reciprocating stopper and having an inlet end and an outlet end; (2) The reciprocating stopper is disposed adjacent to the outlet end of the conduit, and A valve member biased to a normally closed position blocking the outlet end of the tube; (3) a first liquid connector disposed at the conduit inlet end; (4) The second connection is set so as to establish liquid communication between the discharge passage and the conduit. Removing the removable closure removes the first liquid connector at the conduit inlet end. A second collaborator disposed in the discharge passage of the second barrel to engage the 14. The pre-filled syringe system of claim 13, including a working liquid connector. 15. The coupling means is located at the first liquid connector at the conduit inlet. A matable flange and front for threading engagement with the screwable flange. Discharging said second barrel; A thread disposed in the passage to the second cooperating fluid connector of the second barrel. A pre-filled syringe system according to claim 14. 16. The liquid communication means is defined in the reciprocating stopper and is normally closed. Biased to a position and open to the first chamber toward the delivery passage. Elastic with at least one longitudinal through slit defining a possible elastic lip Part, The connecting means, (1) At one end of the wide cavity to define a retaining shoulder around the narrow entrance passage A wide receiving member disposed on the elastic portion of the reciprocating stopper adjacent to the elastic lip. A cavity and a narrow entrance located at the reciprocating stopper to open into the wide cavity Aisle and (2) The reciprocating stopper in which the discharge passage of the second barrel is normally in the biased closed position. The second removable cloth so as to be interrupted by the elastic lip of the par. When the stopper is removed, it is received in the wide receiving cavity of the reciprocating stopper. A wide head disposed in the discharge passage of the second barrel; The second bus so as to be received in the inlet passage of the par. 14. The pre-filled of claim 13, including a narrow neck located in the discharge passage of a rel. Syringe system. 17． The coupling means, (A) connecting means for connecting the second barrel to the reciprocating stopper; (B) for flowing a liquid from the second chamber into the first chamber; A liquid communication means, wherein the liquid circulation means is provided with a first Liquid connector, A second cooperating liquid connector operatively associated with the discharge passage of the second barrel; From the first liquid connector in the reciprocating stopper to the first barrel 12. The pre-filled of claim 11, including an openable liquid passage leading to the first chamber. Syringe system. 18. A luer socket in which the first liquid connector is in liquid communication with the liquid passage; Including a stopper support member with a The second cooperating liquid connector is arranged in liquid communication with the support member. And a luer nozzle disposed in said discharge passage of said second barrel. A syringe system as described in 1. 19. The liquid communication means is defined in the reciprocating stopper, and is normally closed. The delivery passage to be biased in position and to define at least a portion of the liquid passage. A small defining a resilient lip openable into the first chamber towards a path; 19. A resilient central portion having at least one longitudinal through slit. A syringe system as described in 1. 20. The connecting means, At one end of the wide cavity to define a retaining shoulder around the narrow entrance passage A wide receiving member disposed at a central portion of the reciprocating stopper adjacent to the elastic lip. And a reciprocating stopper arranged to open into the wide cavity. Narrow entrance passage, The wide receiving cavity of the reciprocating stopper is defined by the support member. With an acceptable wide head, The reciprocating stopper is defined by the support member and is received in the narrow inlet passage. A narrow neck, wherein the liquid passage is forward through the wide head and the narrow neck. Extending from the luer socket through the longitudinal slit, and The discharge passage of the barrel is normally the biased closing bullet of the reciprocating stopper 20. The pre-filled syringe system of claim 19, which is interrupted by a sex lip.