JP2020074932A - Mixed injection device and drug container equipped with the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a drug container capable of preventing leakage of a drug and smoothly supplying the drug when the drug is supplied from the drug container to the drug container. SOLUTION: A drug container 1 having an opening closed by a rubber stopper can be attached, and a drug container into which a first drug contained in the drug container flows in, and a second drug is housed in the opening. The container body to be held, the inner plug member attached to the opening and having at least one through hole formed, the valve member that opens and closes the through hole, and the container main body attached around the through hole of the inner plug member. A tubular guide portion 44 extending to the outside of the container and a hollow needle member 73 that is guided by the guide portion and supported to move forward and backward with respect to the valve member 5, and the first end portion in the axial direction is a through hole. A contact surface where the needle member and the rubber stopper of the drug container can come into contact with each other so that the valve member can be pressed while facing the side and the second end opposite to the first end is sharply formed. The receiving member 7 has a second end portion of the needle member protruding from the contact surface. [Selection diagram] Figure 8

Description

  The present invention relates to a mixed injection device to which a dissolved drug container having an opening closed by a rubber stopper can be attached, and which supplies a first drug contained in the dissolved drug container, and a drug container including the mixed injection device.

  Patent Document 1 discloses a drug container with a double-ended needle, which is equipped with a drug mixing means for instilling a drug such as an antibiotic drug enclosed in a drug container such as a vial. Various types of such drug containers have been studied in the past, but in general, a container body closed by a rubber stopper and containing an infusion drug such as physiological saline, and a needle with sharp ends A member (double-ended needle) and a mechanism for holding the vial and vertically piercing the double-ended needle into the rubber stopper of the container body and the rubber stopper of the vial are provided.

  The double-ended needle is supported by the mechanism so as to be movable in the axial direction, and when pushed into the container body side, one end of the double-ended needle is inserted into the rubber stopper. The drugs to be mixed are contained in a vial closed with a rubber stopper, and when the rubber stopper of this vial is inserted into the other end of the double-ended needle of the drug container and pushed into the container body, Both ends of the needle are inserted into the rubber stopper of the container body of the drug container and the rubber stopper of the vial bottle, respectively, so that the container body and the vial bottle communicate with each other. Thereby, the drug in the vial can be supplied to the drug container to prepare the mixed solution.

  The mixed solution is then administered to the patient via the catheter. It is also possible that the mixed solution prepared as described above is not directly administered to the patient, but may be further mixed with other infusion preparations and administered to the patient. In this case, the mixed solution is mixed in a container containing another infusion preparation, or a three-way stopcock is provided in the catheter line connected to the other infusion preparation container, and the mixed solution is inserted into the three-way stopcock via the catheter (side tube). It is adopted to connect and administer a container main body in which is stored (so-called piggy bag method).

Japanese Unexamined Patent Publication No. 9-187488 (all text and all drawings) JP-A-6-239352 (paragraph 0013) International Publication No. 2011/030787 (paragraph 0004)

  However, the double-ended needle has a general problem as described in Patent Documents 2 and 3. That is, before the double-ended needle is pierced into the rubber stopper of the lower container of the upper and lower containers (vial 2 in Patent Document 2), the rubber stopper of the upper container (solution container 1 in Patent Document 2) If the double-ended needle is stuck into the needle, the drug in the upper container may leak from the end of the double-ended needle on the lower container side.

  The present invention has been made to solve the above-mentioned problems, and is a mixed injection capable of preventing leakage of a drug in a drug container to be dissolved when communicating a drug container to be dissolved with a drug container such as a vial. An object is to provide an ingredient and a medicine container provided with the ingredient.

  The present invention is a mixed injection device for communicating a drug container to be dissolved with a drug container to move a drug, and an inner stopper member having at least one through hole and a valve member for opening and closing the through hole. A tubular guide portion that is attached around the through hole of the inner stopper member and extends to the outside of the drug container; and a hollow that is supported by the valve member while being guided by the guide portion. The first end portion in the axial direction faces the through hole side and is configured to be able to press the valve member, and the second end portion opposite to the first end portion is a rubber plug. A needle member sharply formed for puncturing, and a first end portion side of the needle member is accommodated in the guide portion in an initial state, and the first end portion of the needle member serves to By pressing the valve member, the valve member is opened.

  According to this configuration, when the drug-dissolved container is attached to the mixed injection tool, when the needle member penetrates the rubber stopper and is stabbed inside the drug-dissolved container, the first end of the needle member becomes the guide part. Since it is contained, even if the first drug passes through the needle member from the dissolved drug container and is discharged to the first end side, the guide portion prevents the first drug from leaking onto the inside plug member. be able to. Then, as the dissolved drug container is inserted into the mixed injection device, the first end of the needle member presses the valve member by its reaction force, so that the through hole of the inner plug member can be exposed. Therefore, the first drug can be supplied from the dissolved drug container to the drug container through the through hole without the first drug leaking from the needle member.

  In the mixed injection device, the valve member is made of an elastic material and is elastically deformed by being pressed by the first aspect of closing the through hole and the first end portion of the needle member, so that the through hole is formed. And a second aspect of opening the.

  According to this configuration, since the valve member is made of the elastic material, the through hole can be liquid-tightly closed. Then, by pressing the valve member with the needle member, the through hole can be opened by elastic deformation. On the other hand, when the pressing by the needle member is released, the elastically deformed valve member returns to the first mode, so that the through hole can be closed again. Therefore, even if another drug container is attached after removing the drug container, the same effect can be obtained.

  When the valve member is formed of an elastic material as described above, the valve member can have various configurations. For example, the valve member includes a fixing portion fixed to the inner plug member and the through hole. A closing part arranged so as to be closed from the inside of the container body; and a connecting part connecting the fixing part and the closing part. In the second aspect, the closing part and / or the connecting part. Can be elastically deformed.

  According to this configuration, since the fixing portion and the closing portion are connected by the connecting portion, when the closing portion is pressed by the first end portion of the needle member, the connecting portion is extended to open the through hole. be able to. On the other hand, when the pressing force of the needle member is released, the connecting portion contracts, so that the elastic force allows the closing portion to close the through hole again.

  In the medicine container, a plurality of the through holes are formed, the first end of the needle member is provided with a number of protrusions smaller than the number of the through holes, and each of the protrusions is The valve member may be configured to open all the through holes when entering the through holes.

  According to this configuration, since the number of through holes is greater than that of the protrusions, the number of through holes into which the protrusions are not inserted is increased, and thus the flow rate of the drug can be increased. Therefore, the first drug can be smoothly flowed into the container body from the needle member.

  In the drug container, the valve member may be an umbrella valve.

  Since the umbrella valve has a simple structure, there is an advantage that the degree of freedom in design is high when the umbrella valve is configured to open and close.

  In the above drug container, the valve member may be configured by a duck bill valve or a flap valve.

  In the medicine container, the entire outer periphery of the needle member on the first end side may be configured to slidably contact the inner wall surface of the guide portion.

  Accordingly, the first end portion side of the needle member and the guide portion are in liquid-tight contact, so that the leakage of the first medicine can be reliably prevented.

  The drug container according to the present invention is a drug container to which a dissolved drug container having an opening closed by a rubber stopper can be attached and which allows the first drug contained in the dissolved drug container to flow in, A container main body containing a drug, having an opening, and having one of the above-mentioned mixed injection tools attached to the opening of the container main body and the contact surface capable of contacting the dissolved drug container, A receiving member having a second end of the needle member protruding from the contact surface.

  With this configuration, the following effects can be obtained. The container body of the conventional drug container has an upper opening closed by a rubber stopper, and a needle member inserted into the rubber stopper is provided. On the other hand, in the present invention, since the upper opening of the container body is closed by the inner plug member having the valve member, there is no rubber plug. Therefore, in the present invention, the needle member that is inserted into the rubber stopper on the side of the drug container is not provided, and only the structure for pushing the valve is provided. This has the advantage that the storage space can be reduced.

  In the above drug container, the container body may include a discharge part capable of discharging a mixed liquid obtained by mixing the first drug and the second drug.

  Accordingly, the mixed first and second drugs can be easily supplied to, for example, a patient.

  According to the present invention, it is possible to prevent leakage of a drug in a drug container to be dissolved when the drug container to be dissolved such as a vial and the drug container are communicated with each other.

It is a front view of the dissolution medicine container concerning one embodiment of the present invention. It is the perspective view which looked at the medicine container for dissolution of Drawing 1 from the upper part. It is a front view which concerns on one Embodiment of the chemical | medical agent container which concerns on this invention. FIG. 4 is a vertical cross-sectional view of a mixed injection device in the medicine container of FIG. 3 and its enlarged view. It is a top view of an inside plug member. It is the perspective view which looked at the receiving member from the lower side. It is a vertical cross-sectional view showing a state in which a dissolved drug container is inserted into a drug container. FIG. 6 is a vertical cross-sectional view showing the mixed injection device in an initial state (a state where the valve member is not pressed). FIG. 9 is a vertical cross-sectional view of the mixed injection device in which the valve member is pressed (a view rotated 90 degrees around the axis from FIG. 8). FIG. 10 is a vertical cross-sectional view rotated 90 degrees around the axis from FIG. 9. It is a top view which shows the other example of an inside plug member. It is a vertical sectional view showing another example of a mixed injection tool. It is a vertical sectional view showing another example of a mixed injection tool.

  Hereinafter, an embodiment of a drug container according to the present invention will be described with reference to the drawings. In this drug container, a vial is attached as a to-be-dissolved drug container accommodating the first drug, and the first drug is introduced therein. Then, the infused first drug is mixed with the second drug contained in the drug container to prepare a mixed solution to be administered to the patient. In the following, a vial bottle and a drug container will be described in this order, and then a method of using these will be described.

<1. Vial Bottle Overview ＞
FIG. 1 is a front view of the vial bottle, and FIG. 2 is a perspective view of the vial bottle as viewed from above in FIG. As shown in FIG. 1, the vial 1 includes a cylindrical main body portion 11 whose lower part is closed by a bottom surface, a shoulder portion 12 which extends obliquely upward from the upper end portion of the main body portion 11, and a shoulder portion 12. It has a cylindrical neck portion 13 extending upward and having a diameter smaller than that of the main body portion 11, and a columnar head portion connected to the neck portion 13 and having an opening in the upper portion. Have been formed in the same way. As shown in FIG. 2, a rubber plug 14 is fitted into the upper opening of the head, and a cap 15 made of aluminum or the like for covering the rubber plug 14 is attached to the head. Further, the first medicine is contained in the internal space surrounded by the main body portion 11, the shoulder portion 12, the neck portion 13, and the head portion. The first drug is not particularly limited, but can be, for example, drugs such as antibiotics and anticancer drugs, and vitamins, and can be liquid or solid. However, in the present embodiment, description will be given assuming that a solid drug is contained. Then, as will be described later, the first drug is supplied into the container body 2 of the drug container 100 via the needle member 73 of the drug container 100 inserted into the rubber stopper 14.

<2. Outline of drug container>
Next, the drug container will be described with reference to FIGS. 3 and 4. FIG. 3 is a front view of the drug container, and FIG. 4 is a cross-sectional view of the mixed injection tool. The enlarged view (a) included in FIG. 4 is an enlarged view of a portion surrounded by a circle, and the enlarged view (b) is an enlarged view at a position rotated 90 degrees around the axis from the enlarged view (a). Is.

  As shown in FIGS. 3 and 4, the medicine container 100 includes a container body 2 having an opening at the top and a mixed injection device 3 attached to the upper opening of the container body 2. The container body 2 includes a main body portion 21 whose horizontal cross section is elliptical with a lower portion closed by a bottom surface, a cylindrical neck portion 22 which extends upward from an upper end of the main body portion 21 and has an opening formed in an upper portion, and a neck portion 22. A flange portion 23 extending radially outward from the upper end is provided, and these are integrally formed of a resin material or the like. Then, as shown in FIG. 3, a mixed injection instrument 3 described later is attached to the upper end of the neck portion 22. Further, the second drug is contained in the internal space of the container body 2. The second drug is not particularly limited, but can be an infusion solution such as physiological saline, glucose solution, Ringer's solution, etc., and dissolves the solid or liquid drug in the vial 1. On the other hand, a discharge part 26 closed with a rubber stopper is formed in the lower part of the container body 2 so that the mixed liquid can be discharged as described later.

<3. Overview of mixed injection tool>
Next, the mixed injection tool 3 will be described with reference to FIGS. 5 and 6. 5 is a plan view of the inside plug member 4 as seen from above, and FIG. 6 is a perspective view of the receiving member 7 as seen from below. The mixed injection tool 3 is a mechanism for supplying the first drug in the vial 1 into the container body 2 of the drug container 100.

  As shown in FIG. 4, the mixed injection device 3 includes a disk-shaped inner plug member 4 that closes the upper opening of the container body 2, a valve member 5 attached to the inner plug member 4, and an upper portion of the inner plug member 4. A support member 6 mounted so as to surround the support member 6 and a receiving member 7 mounted inside the support member 6 are provided.

  The inner plug member 4 includes a disk-shaped base portion 41, an extending portion 42 extending downward from the peripheral edge of the base portion 41, and a circular flange portion 43 extending radially outward from the peripheral edge of the extending portion 42. I have it. Then, the flange portion 43 is fixed to the upper flange portion 23 of the container body 2 by welding.

  As shown in FIG. 5, five through holes 411 to 415 are formed in the center of the base 41. That is, a circular central through hole 411 formed in the center of the base 41 and four elliptical peripheral through holes 412 to 415 arranged at equal intervals so as to surround the periphery thereof are formed. Further, a cylindrical guide portion 44 is integrally formed on the upper surface of the base portion 41 so as to surround the peripheral through holes 412 to 415.

  Next, the valve member 5 will be described. As shown in FIG. 4, the valve member 5 is composed of an umbrella valve, and has a disc-shaped fixing portion 51, a rod-shaped connecting portion 52 extending downward from the lower surface of the fixing portion 51, and a lower surface of the connecting portion 52. And a disc-shaped closing portion 53 connected to the above. These are integrally formed of an elastic material such as synthetic rubber or thermoplastic elastomer. The fixing portion 51 is attached from the upper surface side of the base portion 41 so as to close the central through hole 411, and the connecting portion 52 is inserted into the central through hole 411 and extends to the lower surface side of the base portion 41. The closing portion 53 is attached from the lower surface side of the base portion 41 so as to close the four peripheral edge through holes 412 to 415. Here, since the fixing portion 51 and the closing portion 53 are formed with a diameter larger than that of the central through hole 411, these serve as a retaining member and prevent the valve member 5 from coming off the base portion 41. Further, the fixing portion 51 is larger than the central through hole 411, but is formed in such a size that the four peripheral through holes 412 to 415 are not blocked.

  Further, in the initial state, the fixed portion 51 and the closed portion 53 are in close contact with the upper surface and the lower surface of the base 41, respectively. That is, the fixing portion 51 liquid-tightly closes the central through hole 411, and the closing portion 53 liquid-tightly closes the four peripheral through holes 412 to 415.

  Next, the support member 6 will be described. The support member 6 is fixed to the peripheral edge of the inner plug member 4, and has a cylindrical base portion 61 that extends upward from here, and a circular extending portion 62 that extends radially outward from the upper end of the base portion 61. , A cylindrical accommodating portion 63 extending upward from the peripheral edge of the extending portion 62, and these are integrally formed. The accommodating portion 63 has an inner diameter that is substantially the same as the outer diameter of the main body portion 11 of the vial bottle 1, and a part of the main body portion 11 is accommodated. Further, the base member 61 is adapted to accommodate the receiving member 7 as described later.

  Next, the receiving member 7 will be described. The receiving member 7 is attached to the cylindrical main body 71, a disk-shaped partition 72 for vertically partitioning the inside of the main body 71 near the axial center of the main body 71, and the partition 72. And a cylindrical needle member 73, which are integrally formed. The main body 71 is partitioned by a partition 72 into an upper space 701 and a lower space 702. In the following, in the needle member 73, the portion protruding toward the lower space 702 side is referred to as the first portion 731, and the portion protruding toward the upper space 701 side is referred to as the second portion 732.

  The main body 71 is housed in the base 61 of the support member 6 and is supported in the base 61 so as to be vertically movable. Therefore, the outer diameter of the main body 71 is substantially the same as the inner diameter of the base 61. The inner diameter of the main body portion 71 is substantially the same as the outer diameter of the cap 15 of the vial bottle 1, and the head portion of the vial bottle 1 is housed in the upper space 701. Further, in the body portion 71, a plurality of slits 711 extending in the axial direction are formed above the partition portion 72, whereby the upper portion of the body portion 71 opens in the radial direction. The upper portion of the main body portion 71 serves as a guide when inserting the vial bottle 1 and is formed higher than the tip of the needle member 73 to prevent the finger member 73 from touching the finger. Although not shown, as shown in FIG. 7 described later, when the vial bottle 1 is inserted, the upper portion of the main body portion 71 opens along the shoulder portion 12 of the vial bottle 1. Further, an engagement portion 712 that slightly projects inward in the radial direction is formed on the inner wall surface of the main body portion 71 on the upper space 701 side, and this engagement portion 712 is the cap 15 of the vial 1 (see FIG. 7). By engaging with, it is possible to prevent the vial bottle 1 fixed in the upper space 701 from coming off.

  The main body 71 is restricted from moving upward in the base 61 by a stopper (not shown). That is, the main body 71 can be moved downward from the initial position in the base 61, but cannot be moved upward from the initial position by the stopper.

  The needle member 73 is formed in the shape of a rod, extends vertically through the partition 72, and has one or more flow paths (two in FIG. 4) penetrating the needle member 73 in the axial direction. A flow path) is formed. One of these flow paths is a drug flow path and the other is an air flow path. The upper end of the second portion 732 of the needle member 73 is sharply formed so as to be inserted into the rubber stopper 14 of the vial 1. On the other hand, the first portion 731 of the needle member 73 is formed in a cylindrical shape and is accommodated in the guide portion 44 in the initial state. More specifically, the outer diameter of the first portion 731 of the needle member 73 is substantially the same as the inner diameter of the guide portion 44, and the first portion 731 can slide in the guide portion 44 in a liquid-tight manner. .. Further, as shown in FIGS. 4B and 6, two rod-shaped protrusions 734 extending downward are formed at the lower end of the first portion 731. These protrusions 734 are attached so as to sandwich the axial center of the needle member 73, and are inserted into two facing peripheral edge through holes 412, 414 among the peripheral edge through holes 412 to 415 described above. .. However, in the initial state, as shown in FIG. 4B, the protrusion 734 does not completely penetrate the peripheral through holes 412 to 415 and is inserted to such an extent that the valve member 5 is not pressed. Further, a plate-shaped partition member 737 is provided between the both protrusions 734 near the upper ends of the both protrusions 734, and partitions near the lower openings of the two flow paths of the needle member 73. ..

<4. How to use the drug container>
Next, a method of using the medicine container 100 will be described with reference to FIGS. 7 to 10. FIG. 7 is a cross-sectional view showing a state where the medicine container is inserted into the medicine container, and FIGS. 8 to 10 are cross-sectional views of the mixed injection device. However, FIG. 9 is a cross-sectional view rotated 90 degrees around the axis from FIGS. 8 and 10. However, in FIGS. 8 to 10, the neck portion 22 and the flange portion 23 of the container body 2 are omitted. First, the cap 15 of the vial bottle 1 is attached to the receiving member 7 of the medicine container 100. That is, as shown in FIG. 7, the cap 15 is inserted into the upper space 701, and the vial 1 is pushed into the receiving member 7 so that the second portion 732 of the needle member 73 is inserted into the rubber stopper 14. At this time, the cap 15 of the vial bottle 1 is supported by the main body portion 71 of the receiving member 7. Further, the outer peripheral surface of the main body 11 of the vial 1 is supported by the accommodating portion 63 of the support member 6.

  Then, as shown in FIG. 8, the cap 15 of the vial bottle 1 is pushed so as to come into contact with the partition portion 72 of the receiving member, and when the vial bottle 1 is pushed further from here, the receiving member 7 is pushed toward the inner plug member 4 side. Then, the inside of the support member 6 is slid to the container body 2 side. At this time, the first portion 731 of the needle member 73 slides in the guide portion 44, and the protrusion 734 enters the peripheral through holes 412 and 414 as shown in FIG. 9. As a result, the closing portion 53 that closes the peripheral through holes 412 and 414 from below is pressed by the protrusion 734, and the closing portion 53 is separated from the base portion 41. As a result, as shown in FIG. 10, the peripheral through-holes 413, 415 are opened, and the needle member 73 and the container body 2 communicate with each other. At this time, when the protrusion 734 presses the closing portion 53, the connecting portion 52 and the closing portion 53 of the valve member 5 are elastically deformed and extend, and the closing portion 53 is separated from the lower surface of the base 41. Further, since the partition member 737 is in contact with the upper end of the valve member 5, the space from the two flow paths of the needle member 73 to the peripheral through holes 412 and 414 is divided into two. As a result, one of the two flow paths of the needle member serves as a medicine passage and the other serves as an air passage, so that the medicine smoothly flows.

  In this way, the vial 1 and the drug container 100 communicate with each other via the needle member 73. Then, the upside down is repeated with the vial 1 and the drug container 100 integrated. That is, the second drug in the container body 2 is moved to the vial bottle 1 to dissolve the first drug, and then the dissolved drug is moved to the container body 2. A liquid mixture is prepared by repeating this operation. Then, when another drug is mixed, the vial 1 is pulled out from the drug container 100. As a result, the needle member 73 and the receiving member 7 move upward together with the vial 1. Then, the stopper stops the movement of the receiving member 7. At this time, since the needle member 73 is moving in the direction away from the medicine container 100, the pressing of the valve member 5 by the protrusion 734 is released. As a result, the connecting portion 52 contracts, and the peripheral portion through holes 412 to 415 are liquid-tightly closed again by the closing portion 53. After that, when the vial bottle 1 is further pulled, the needle member 73 is pulled out from the rubber stopper 14.

  Subsequently, a new vial is attached to the drug container 100 and the drug contained therein is supplied into the drug container 100 by the same method as described above. In this way, when all the medicines are supplied into the medicine container 100, the mixed liquid is prepared. Then, the drug container 100 may be hung on a drip stand or the like, and the rubber stopper of the discharge part 26 may be pierced with the needle member of the catheter to administer the mixed solution to the patient. It is also possible that the mixed solution prepared as described above is not directly administered to the patient, but may be further mixed with other infusion preparations and administered to the patient. In this case, the mixed solution is mixed in a container containing another infusion preparation, or a three-way stopcock is provided in the catheter line connected to the other infusion preparation container, and the mixed solution is inserted into the three-way stopcock via the catheter (side tube). It is adopted to connect and administer a container main body in which is stored (so-called piggy bag method).

<5. Features>
According to this embodiment, the following effects can be obtained.
(1) In the conventional example, if the needle member is inserted into the rubber stopper of the vial before the needle member is inserted into the rubber stopper of the medicine container, the medicine may leak. Therefore, in the conventional example, it is necessary to control the operation sequence so that the needle member is inserted into the rubber stopper of the vial bottle after the needle member is inserted into the rubber stopper of the drug container.

  On the other hand, in the present embodiment, when the vial 1 is attached to the drug container 100, the first portion 731 of the needle member 73 slides while being in close contact with the guide portion 44, so that the first drug is transferred from the needle member 73 to the inside plug member. 4 can be prevented from leaking. Then, as the needle member 73 is inserted into the rubber plug 14, the first portion 731 of the needle member 73 presses the valve member 5 with its reaction force, so that the peripheral edge through holes 412 to 415 of the inner plug member 4 are closed. It can be opened easily. Therefore, the first medicine can be supplied from the vial 1 to the medicine container 100 via the peripheral through holes 412 to 415 without leaking from the needle member 73.

  Even if the protrusion 734 presses the valve member 5 before the needle member 73 is inserted into the rubber stopper 14 of the vial bottle 1, the valve member 5 moves and the peripheral through holes 412 to 415 open. The order of the movement of the valve member 5 and the insertion of the needle member 73 into the rubber plug 14 does not need to be particularly limited, and the design is simple.

(2) In the conventional example, since the needle member is pierced into the rubber stopper of the medicine container to supply the medicine, the needle member needs to be reliably pierced into the rubber stopper. Further, when the inserted needle member is pulled out, the portion torn by the needle member must be closed, so it was necessary to adjust the volume, thickness, tightening degree, etc. of the rubber plug. On the other hand, in the present embodiment, the peripheral edge through holes 412 to 415 are opened by simply pressing the valve member 5 with the protrusion 734, so that the elasticity of the valve member 5 may be mainly considered. As compared with the case where the rubber stopper is used, the opening and closing can be performed with a small valve member.

  Further, in the conventional example, if the needle member is repeatedly inserted, the rubber stopper of the drug container may be damaged, and the rubber stopper may not close when the needle member is pulled out. On the other hand, in this embodiment, the valve member 5 is pressed by the protrusion 734 of the needle member 73, and the connecting portion 52 and the closing portion 53 of the valve member 5 are mainly expanded and contracted. Since 415 is opened and closed, deterioration of opening and closing of the peripheral through holes 412 to 415 can be reduced as compared with the conventional example. Therefore, for example, even if a plurality of drug containers are attached to the mixed injection device 3 multiple times, it is possible to prevent the drug from leaking.

(3) Of the four peripheral through holes 412 to 415, only two of the protrusions 734 of the needle member 73 enter, so that the remaining two peripheral through holes 412 and 414 allow the drug and air to flow. be able to. Therefore, as the first medicine is supplied into the container body 2 of the medicine container 100, air is discharged from the container body 2 through the air holes, so that the first medicine is smoothly supplied into the container body 2. can do. In addition, when the size of the horizontal cross section of the protrusion 734 is smaller than the through holes 412 to 415, the medicine and the air can be circulated through the through holes 413 and 415 into which the protrusion 734 enters.

(4) Unlike the conventional example, the needle member 73 is not formed with a sharp portion that is pierced on the side of the drug container 100, and is not provided with a rubber plug that pierces this sharp portion. Therefore, the mixed injection instrument 3 can be formed compactly, and the height of the entire drug container 100 in the vertical direction can be reduced.

<6. Modification>
Although one embodiment of the present invention has been described above, the present invention is not limited to the above embodiment, and various modifications can be made without departing from the spirit of the present invention. For example, the following modifications can be made, but the following modifications can be combined as appropriate.

<6-1>
In the above embodiment, the four peripheral through holes 412 to 415 are formed in the inner plug member 4, but the number thereof is not particularly limited. The number of protrusions 734 is also the same. The shape of the protrusion 734 is not particularly limited as long as its horizontal cross section is formed smaller than the through holes 412 to 415. Therefore, as shown in FIG. 11A, two peripheral through holes 416 and 417 may be formed, or as shown in FIG. 11B, one peripheral through hole 418 may be formed. it can. As shown in FIG. 11B, one peripheral through hole 418 can be formed in, for example, a C shape, but in this case, one peripheral through hole 418 is formed to facilitate pressing of the closing portion 53. A plurality of protrusions 734 located at distant positions can be inserted into the peripheral through hole 418. The configuration of the first portion 731 of the valve member 5 is not particularly limited, and the shape other than the protrusion 734 is not particularly limited as long as the valve member 5 can be pressed.

<6-2>
The configuration of the valve member 5 is not particularly limited as long as the through hole is closed by the valve, and the through hole can be opened by pressing the valve with the needle member 73. For example, as shown in FIG. 12A, one through hole 410 formed in the inner plug member 4 can be closed by a known duck bill valve 5 having a slit 55. Then, as shown in FIG. 12 (b), the protrusion 738 formed on the needle member 73 enters the slit 55 of the duckbill valve 5 to open the duckbill valve 5 so that the medicine passes therethrough. You can

  Alternatively, the flap valve 5 as shown in FIG. 13A can close the one through hole 410 formed in the inner plug member 4. The flap valve 5 is formed in a circular or rectangular shape so as to close the through hole 410, and like the other valves, it can be formed in a plate shape with an elastic material such as synthetic rubber or thermoplastic elastomer. The flap valve 5 has one end fixed to the inside plug member 4 outside the through hole 410. As a result, in the state shown in FIG. 13A, the flap valve 5 is held at the position where it closes the through hole 410 from below by the elastic force. On the other hand, as shown in FIG. 13B, when pressed from above by the needle member 73 inserted into the through hole 410, the flap valve 5 swings around one end to open the through hole 410. Is configured. This allows the drug to pass through the through hole.

<6-3>
In the above embodiment, the support member 6 that slidably supports the receiving member 7 is provided, but the supporting mechanism is not particularly limited as long as the receiving member 7 is movably supported together with the needle member 73.

<6-4>
The shape of the mixed injection tool 3 is an example, and may be a shape other than a circular shape, and can be appropriately changed.

<6-5>
The shape of the container body 2 of the drug container 100 is not particularly limited. Further, the discharging unit 26 does not necessarily have to be provided. Further, the drug container 100 may contain a first drug other than the infusion solution, and the type of drug is not particularly limited.

<6-6>
Although the vial bottle has been described as the dissolved drug container of the present invention in the above-described embodiment, a container other than the vial container, for example, a resin container containing the first drug that is the dissolved drug, etc., is also the dissolved drug container. Can be used.

<6-7>
The structure of the receiving member 7 is not particularly limited, and the inner diameter of the main body portion 71 does not necessarily have to be the same as the outer diameter of the cap 15 of the vial bottle 1. If the cap 15 can be fitted, it may be slightly larger, Alternatively, it may be small. Further, in order to hold the vial bottle 1, it may have a configuration other than the engaging portion 712.

<6-8>
The mixed injection tool according to the present invention can be used in a manner other than the aspects described in the above-described embodiment, and can be attached to various drug containers (container body). Further, the receiving member 7 and the supporting member 6 are not necessarily required, and are configured so that when the needle to be dissolved drug is inserted into the needle member 73, the needle member 73 can be moved to press the valve member 5. However, the structure is not particularly limited.

1 Vial bottle (dissolved drug container)
14 Rubber stopper 100 Drug container 3 Mixed injection tool 4 Middle stopper members 412 to 415 Peripheral through hole (through hole)
44 Guide part 5 Valve member 51 Fixed part 52 Connecting part 53 Closing part 7 Receiving member 73 Needle member 731 1st part (1st end part)
732 Second part (second end)

Claims (10)

A mixed injection device for communicating a drug container to be dissolved with a drug container to move the drug,
An inner plug member having at least one through hole, and a valve member that opens and closes the through hole,
A cylindrical guide portion that is attached around the through hole of the inner stopper member and extends to the outside of the drug container,
A hollow needle member supported by the guide portion so as to be capable of advancing and retracting with respect to the valve member, and a first end portion in the axial direction faces the through hole side and is capable of pressing the valve member. A needle member having a second end opposite to the first end formed sharply so that a rubber plug can be punctured;
Equipped with
The first end portion side of the needle member is accommodated in the guide portion in the initial state, and is configured to open the valve member by pressing the valve member by the first end portion of the needle member. It is a mixed injection tool. The valve member is formed of an elastic material,
A first aspect of closing the through hole,
A second aspect in which the needle member is elastically deformed by being pressed by the first end portion of the needle member to open the through hole,
The mixed injection instrument according to claim 1, wherein the mixed injection instrument is configured to be The valve member is
A fixing portion fixed to the inner plug member,
A closing portion arranged so as to close the through hole,
A connecting portion that connects the fixing portion and the closing portion,
Equipped with
The mixed injection tool according to claim 2, wherein in the second aspect, the closing portion and / or the connecting portion is configured to elastically deform. A plurality of the through holes are formed,
The first end portion of the needle member has a number of protrusions smaller than the number of the through holes,
The mixed injection tool according to any one of claims 1 to 3, wherein the valve member is configured to open all the through holes when the respective protrusions enter any of the through holes.   The mixed injection device according to claim 1, wherein the valve member is an umbrella valve.   The mixed injection tool according to claim 1, wherein the valve member is configured by a duckbill valve.   The mixed injection device according to claim 1, wherein the valve member is a flap valve.   The mixed injection tool according to any one of claims 1 to 7, wherein the entire outer periphery of the needle member on the side of the first end is slidably in contact with the inner wall surface of the guide portion. A drug container to which a dissolved drug container having an opening closed by a rubber stopper can be attached and which allows the first drug contained in the dissolved drug container to flow in,
A container body containing a second drug and having an opening;
The mixed injection tool according to any one of claims 1 to 8, which is attached to an opening of the container body,
A receiving member having a contact surface with which the dissolved drug container can contact, and a second end of the needle member protruding from the contact surface;
And a drug container.   The drug container according to claim 9, wherein the container main body includes a discharge unit capable of discharging a mixed liquid in which the first drug and the second drug are mixed.