JPH10130131A - Oily transparent skin preparation for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject medicine having excellent moisture retaining effect by including a lipid of Laticauda colubrina and a specific water-soluble polymer compound. SOLUTION: This medicine comprises 0.01-2wt.% lipid of Laticauda colubrina and 0.0001 to 0.1wt.% water-soluble polymer compound selected from sodium hyaluronate, sodium chondroitin sulfate, elastin and collagen in a transparent skin preparation for external use by using an oily substance as a base. The lipid of Laticauda colubrina is a lipid extracted from Laticauda colubrina which is a marine venomous snake and the lipid contains eicosapentaenoic acid and docosahexaenoic acid particular to fish oil so tat high beautifying effect is expected. Thereby, excellent moisture retaining effect is exhibited and conditions of roughened skin and dried skin can be improved by applying the medicine to healthy skin or roughened skin or skin having drying symptom.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oily transparent external preparation for skin, and more particularly, to a skin preparation containing a specific water-soluble polymer compound in an oil preparation containing an oil-soluble animal extract component. The present invention relates to a liquid oily transparent external preparation for the skin which has an effect of improving skin conditions.

[0002]

2. Description of the Related Art Skin external preparations based on oily substances, such as cosmetic oils, are well known, and are said to exhibit a softening effect and a moisturizing effect on the skin. Such oils function to moderately control the volatilization of water on the skin, but are insufficient in terms of hydration of the skin, and are expected to have the ideal effect of improving skin symptoms such as rough skin and swelling. Can not. From such a background, an oily transparent skin external preparation that can sufficiently exert a moisturizing effect on the skin has been desired.

[0003]

SUMMARY OF THE INVENTION An object of the present invention is to provide an oily transparent skin external preparation which exhibits an excellent moisturizing effect on the skin.

[0004]

Means for Solving the Problems The present inventors have conducted intensive studies in order to solve the above-mentioned problems, and as a result, a clear skin external preparation based on an oleaginous substance, Erabu sea snake lipid,
By containing a specific water-soluble polymer compound,
Finding that a skin external preparation with excellent moisturizing effect can be obtained,
The present invention has been completed. Accordingly, the present invention relates to an oil-based transparent skin external preparation characterized by containing a sea urchin snake lipid, and at least one selected from the group consisting of sodium hyaluronate, sodium chondroitin sulfate, elastin and collagen.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION The Erabu sea snake lipid used in the present invention is known as a lipid extracted from the marine venomous snake, Erabu sea snake (also known as Era sea eel). Elab sea snake lipids are composed of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DH), which are unique to fish oil.
It is known to contain a large amount of A). EPA has been confirmed to have a blood circulation promoting effect, and DHA has been confirmed to have a constitution improving effect for allergy. It is also known that Erabu sea snake lipids contain fat-soluble vitamins such as vitamin A, vitamin D ₃ , vitamin E, and essential fatty acids such as linoleic acid, linolenic acid, and arachidonic acid. Elab sea snake lipids are expected to have high cosmetic effects due to these components. Elab sea snake lipids are generally available on the market,
In the present invention, such commercially available products can be used.
The content of Erabu sea snake lipid in the oily transparent skin external preparation of the present invention is 0.01 to 0.01% based on the total weight of the skin external preparation.
2.0% by weight is suitable, preferably 0.05 to 1.0% by weight. If the amount of the sea urchin snake lipid is less than 0.01% by weight, the effects intended by the present invention will not be sufficiently exhibited, and if it exceeds 2.0% by weight, discoloration or odor tends to occur.

The water-soluble polymer compound used in the present invention is
It is at least one selected from sodium hyaluronate, sodium chondroitin sulfate, elastin and collagen. Therefore, one of these can be used alone, or two or more can be used in combination. Sodium hyaluronate is a kind of mucopolysaccharide originally extracted from chicken crow, and is known to have an excellent water retention effect. At present, many are collected from cultured microorganisms. It is used as a component of an external preparation for skin and can be obtained on the market. In the present invention, such a commercially available product can be used. Sodium chondroitin sulfate is a kind of mucopolysaccharide like sodium hyaluronate and is obtained from animal cartilage as a raw material. It is used as a humectant and can be obtained on the market, and such a commercially available product can be used in the present invention.

[0007] Elastin is a type of hard protein and is an elastic protein contained in connective tissues of mammals. Collagen is also a type of hard protein and is a major component of the intercellular material in tissues of all animals except arthropods. Elastin and collagen are generally obtained using bovine or porcine skin as a raw material, and usually use those which have been rendered water-soluble by hydrolysis treatment or chemical modification. These are commercially available, and such commercially available products can be used in the present invention. The above-mentioned water-soluble polymer compound has a form of powder, gel, aqueous solution and the like, and any form can be used for producing the oily transparent external preparation for skin of the present invention. The content of the water-soluble polymer compound in the oily transparent external preparation for skin of the present invention is suitably 0.0001 to 0.1% by weight based on the total weight of the external preparation for skin, and is preferably used.
0.0005 to 0.05% by weight. If the amount of these water-soluble polymer compounds is less than 0.0001% by weight, the effects intended by the present invention will not be sufficiently exerted. If the amount exceeds 0.1% by weight, the transparency of the external preparation will be reduced. It cannot be maintained and the stability of the external preparation for skin tends to decrease.

The base in the oily transparent skin external preparation of the present invention is a liquid at room temperature. For example, liquid paraffin, mineral oil such as isoparaffin, squalane, vegetable squalane, carrot oil, eucalyptus oil, olive oil, animal and vegetable oils such as jojoba oil, glyceryl 2-ethylhexanoate, isononyl isononanoate, isostearic acid,
Isocetyl myristate, cetostearyl octoate,
And synthetic oils such as hexyldecanol and isopropyl myristate. The oily transparent skin external preparation of the present invention includes:
In addition, solvents such as water, ethanol, glycerin, propylene glycol, 1,3-butylene glycol, dipropylene glycol, sorbitol, and maltitol are usually used.
About 0.001 to 5% by weight, dibutylhydroxytoluene, tocopherol acetate, natural vitamin E, antioxidants such as ascorbic acid and its salts, parabens, benzoic acid and its salts, salicylic acid and its salts, sorbic acid and its salts Preservatives such as triclosan, triclocarban, benzalkonium chloride, benzethonium chloride, phenoxyethanol, lecithin derivatives, glycerin fatty acid esters, polyglycerin fatty acid esters, sorbitan fatty acid esters, polyoxyethylene (POE) sorbitan fatty acid esters, POE sorbit fatty acid esters ,
Surfactants such as POE hydrogenated castor oil, POE alkyl ethers, and polyethylene glycol fatty acid esters, coloring agents, flavoring agents, and the like can be appropriately included. The amounts of these additives may be such that they are usually added to oily skin external preparations. The oily transparent skin external preparation of the present invention includes other active ingredients such as vitamin A, vitamin D, vitamin E (tocopherol acetate), vitamin B group (riboflavin, pyridoxine derivative), and ascorbin as long as the object of the present invention can be achieved. Acids and derivatives thereof, vitamins such as panthenol, glycyrrhizic acid and salts thereof, glycyrrhetinic acid, licorice extracts such as stearyl glycyrrhetinate and derivatives thereof, placenta extract, allantoin, guaiazulene sulfonic acid and salts thereof. it can.

It is desirable to appropriately select a surfactant in the oily transparent skin external preparation of the present invention in order to stably blend the water-soluble polymer compound without separating it. Preferred surfactants include, for example, sorbitan fatty acid esters and / or glycerin fatty acid esters.
The surfactant preferably has a total HLB in the range of 3 to 7. The amount of the surfactant is usually about 0.1 to 10% by weight based on the total weight of the oily transparent external preparation for skin. As an example of the method for producing the oil-based transparent skin external preparation of the present invention, first, a water-soluble polymer compound, a surfactant and a solvent are uniformly mixed, and this mixture is added to a mixed liquid of a base oil agent. No. In addition, you may heat suitably as needed.

[0010]

The oil-based transparent skin preparation for external use of the present invention exerts an excellent moisturizing effect when applied to healthy skin and skin having symptoms such as rough skin and swelling, and improves such symptoms. be able to.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples.

Examples 1 to 4 and Comparative Examples 1 to 7
Various oily transparent skin external preparations were prepared. 1. Erabu sea snake lipids (see Table 1 below) 2. Sodium hyaluronate (see Table 1 below) 3. Isoparaffin 30.0 parts by weight 4. Paraben 0.2 〃 5. Purified water 0.2 〃 6. Monoisostearic acid Sorbitan 1.0 〃 7. Squalane Total remaining amount 100.0 parts by weight In the preparation procedure, the above 2, 5 and 6 were mixed uniformly, and this was added to the mixed solution of 1, 3, 4 and 7 and dissolved.

The transparency and stability of the various oily transparent skin external preparations obtained above were observed. Transparency was visually observed immediately after production. ○ ‥‥ Almost transparent to transparent × ‥‥ Slightly cloudy to cloudy For stability, after storage at 40 ° C. for 1 month after production,
The transparency was visually observed again and evaluated. ○ ‥‥ Almost transparent to transparent × ‥‥ Slightly cloudy to cloudy The results are shown in Table 1 below.

[0013]

[Table 1] Elab sea snake lipid Sodium hyaluronate Transparency Stability (Parts by weight) (parts by weight) １ Example 1 0.05 0.01 ○ ○ Example 2 0.05 0.001 ○ ○ Example 3 0.1 0.001 ○ ○ Example 4 0.5 0.001 ○ ○ −−−−−−−−−−−−−− −−−−−−−−−−−−−−−−−−−−−−−−−− Comparative example 1 0.05 0 ○ ○ Comparative example 2 0.1 0 ○ ○ Comparative example 3 0.5 0 ○ ○ Comparative Example 4 0.1 0.000001 ○ ○ Comparative Example 5 0.1 0.15 × × Comparative Example 60 0.001 ○ ○ Comparative Example 700 0 ○ ○ ─────────── ─────────────────────────

[Test for Improvement Effect on Skin Quality] Ten panelists (7 women, 3 boys) were panelists, and the oily transparent skin external preparation of Comparative Example 3 was applied to the left outer arm, and the outer right arm was used. Part of the oily transparent skin external preparation of Example 4 according to the present invention,
Each of them was applied twice a day in the same manner as in normal use, and this was continued for 20 days.
The four criteria of gloss, moist feeling, and freshness were evaluated using the following standard scores, and the average value of 10 subjects was evaluated. The results are shown in Table 2 below.

[0015]

[Table 2] ハ リ Smoothness and moist feeling み──────────────────────────────── Example 4 5.4 4.8 5.3 4.0 Comparative Example 3 3.5 4.1 3.6 2.9 ────────────────────────────────────

[0016]

Example 5 An oily transparent external preparation for skin was prepared according to the following composition (unit: parts by weight). 1. Elab sea snake lipid 0.5 2. Sodium hyaluronate 0.001 3. Eucalyptus oil 0.01 4. Carrot oil 0.01 5. Jojoba oil 0.1 6. Natural vitamin E 0.05 5. Monoisostearic acid Sorbitan 0.5 8. Purified water 0.1 9. Isononyl isononanoate 30.0 10. Total amount of squalane 100.0 As a preparation procedure, the above 2, 7, and 8 were mixed uniformly, and 1
And 9 and then add this solution to the remaining 3-6 and 1
0 to make the mixture uniform.

[0017]

Example 6 An oily transparent external preparation for skin was prepared according to the following composition (unit: parts by weight). 1. Elab sea snake lipid 0.1 2. Sodium hyaluronate 0.001 3. Olive oil 0.1 4. Macadamia nut oil 0.1 5. Jojoba alcohol 0.1 6. Natural vitamin E 0.05 5. Sorbitan monoisostearate 0.4 8. Sorbitan trioleate 0.1 9. Purified water 0.1 10. Isocetyl myristate 30.0 11. Total amount of residual squalane 100.0 As a preparation procedure, the above steps 2, 7 to 9 should be performed uniformly. Mix, 1
And 10 and then the mixture was added to the remaining mixture of 3-6 and 11 to make it homogeneous.

[0018]

Example 7 An oily transparent skin external preparation was prepared according to the following composition (unit: parts by weight). 1. Elab sea snake lipids 0.1 2. Sodium hyaluronate 0.001 3. Olive oil 0.1 4. Macadamia nut oil 0.1 5. Parabens 0.1 6. Flavors 0.05 5. Sorbitan monoisostearate 0.4 8. Sorbitan trioleate 0.1 9. Purified water 0.1 10. Hexdecanol 20.0 11. Total squalane balance 100.0 As a preparation procedure, the above 2, 7 to 9 were mixed uniformly, and 1
And 10 and then the mixture was added to the remaining mixture of 3-6 and 11 to make it homogeneous.

Claims (1)

[Claims] 1. An oil-based transparent external preparation for skin, comprising a sea bream snake lipid and at least one selected from the group consisting of sodium hyaluronate, sodium chondroitin sulfate, elastin and collagen.