JPH10130112A - Composite material inhibiting propagation of various saprophytes - Google Patents
Composite material inhibiting propagation of various saprophytesInfo
- Publication number
- JPH10130112A JPH10130112A JP8307210A JP30721096A JPH10130112A JP H10130112 A JPH10130112 A JP H10130112A JP 8307210 A JP8307210 A JP 8307210A JP 30721096 A JP30721096 A JP 30721096A JP H10130112 A JPH10130112 A JP H10130112A
- Authority
- JP
- Japan
- Prior art keywords
- titanium oxide
- spheres
- propagation
- hydroxyapatite
- composite material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Inorganic Compounds Of Heavy Metals (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Manufacture Of Alloys Or Alloy Compounds (AREA)
- Materials For Medical Uses (AREA)
- Dental Preparations (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、雑菌繁殖防止体、
および雑菌繁殖防止複合材料に関するものであり、さら
に詳しくは、本発明は、基板に酸化チタン球状体または
酸化チタンを被覆した球体を圧入したことを特徴とする
雑菌の繁殖を防止するのに有用な雑菌繁殖防止体、ま
た、基板に酸化チタン球状体または酸化チタンを被覆し
た球体、および／またはハイドロキシアパタイト球体等
を圧入したことを特徴とする生体材料として有用な雑菌
繁殖防止複合材料、等に関するものである。本発明の雑
菌繁殖防止体は、プール、水槽等の雑菌の繁殖の防止に
有用であり、また、上記雑菌繁殖防止複合材料は、人工
歯冠や歯根、人工骨などの生体材料として有用である。TECHNICAL FIELD The present invention relates to an antibacterial growth inhibitor,
The present invention relates to a composite material for preventing bacterial growth, and more particularly, the present invention is useful for preventing the propagation of various bacteria, characterized in that a titanium oxide spherical body or a spherical body coated with titanium oxide is pressed into a substrate. An antibacterial growth inhibitor, a composite material that is useful as a biomaterial, characterized in that a titanium oxide sphere or a sphere coated with titanium oxide on a substrate and / or a hydroxyapatite sphere is pressed into the substrate. It is. The germ propagation preventive body of the present invention is useful for preventing germ propagation in pools, aquariums, and the like, and the germ propagation prevention composite material is useful as a biomaterial such as an artificial crown, a root, or an artificial bone. .
【０００２】[0002]
【従来の技術】一般に、プール等では底や壁、タイルな
どにぬめりが生じてすべりやすくなり危険なことがあ
る。また飲料水でも長期間保存すると雑菌が繁殖し腐敗
してしまう。従来、水等の浄化のために酸化チタンの粉
末を用いて、光を照射しその光触媒機能により有機不純
物等の分解処理を行うことが試みられている。しかし、
処理後の水と酸化チタンの粉末の分離が難しく実用化で
きなかった（久永輝明，原田賢二，田中啓一，工業用
水，３７９号，１２（１９９０））。細菌やバクテリア
の殺菌では酸化チタンにそれらの菌が吸着しないと効果
が得られないが、従来の酸化チタン膜を被覆した板等で
はそれらの菌を十分に吸着することができず効率が悪か
った（青木編，バイオセラミックスの開発と臨床，ｐ１
５８，クインテッセンス出版（１９８７））。また、人
工歯冠や歯根などでは虫歯菌などが付着する問題があっ
た。特にハイドロキシアパタイトなど生体親和性の良い
材料ではそれらの付着が多い。また、人工骨では手術後
に雑菌が繁殖する問題がある。人工骨の親和性の向上の
ために金属基板にハイドロキシアパタイトを溶射被覆し
たものがあったが剥離することがあった。またハイドロ
キシアパタイトを被覆した人工骨はＴＣＰを被覆したも
のに比べ初期固定が遅い。逆にＴＣＰを被覆したものは
長期の固定がよくない。2. Description of the Related Art Generally, in a pool or the like, the bottom, walls, tiles and the like are slimy and slippery, which may be dangerous. Also, if stored for a long time even in drinking water, various bacteria grow and rot. BACKGROUND ART Conventionally, attempts have been made to use titanium oxide powder to purify water and the like, irradiate light, and perform a decomposition treatment of organic impurities and the like by the photocatalytic function. But,
Separation of the water and titanium oxide powder after the treatment was difficult and could not be put to practical use (Teruki Kukunaga, Kenji Harada, Keiichi Tanaka, Industrial Water, 379, 12 (1990)). In the sterilization of bacteria and bacteria, the effect cannot be obtained unless the bacteria are adsorbed to titanium oxide, but the conventional titanium oxide film-coated plate etc. could not adsorb those bacteria sufficiently and the efficiency was poor (Aoki, Bioceramics Development and Clinical Practice, p1
58, Quintessence Publishing (1987)). In addition, there is a problem that carious bacteria and the like adhere to artificial tooth crowns and roots. Particularly, materials having good biocompatibility, such as hydroxyapatite, often adhere to them. In addition, artificial bones have a problem that bacteria grow after surgery. In some cases, a metal substrate was spray-coated with hydroxyapatite to improve the affinity of the artificial bone. The initial fixation of hydroxyapatite-coated artificial bone is slower than that of TCP-coated artificial bone. Conversely, those coated with TCP have poor long-term fixation.
【０００３】[0003]
【発明が解決しようとする課題】このような状況の中
で、本発明者らは、上記従来技術に鑑みて、上記問題を
解消することが可能な新しい雑菌繁殖防止材等を開発す
ることを目標として鋭意研究を積み重ねた結果、基板に
酸化チタン球状体または酸化チタンを被覆した球体、お
よびハイドロキシアパタイト球体等を圧入することによ
って、所期の目的を達成し得ることを見出し、本発明を
完成するに至った。本発明は上記の点に鑑み、主に省エ
ネルギー的でかつ安全に雑菌の繁殖を防止できる経済的
な雑菌繁殖防止体および生体材料として有用な雑菌繁殖
防止複合材料を提供することを目的とするものである。In such a situation, the present inventors have developed a new germ propagation preventing material capable of solving the above-mentioned problems in view of the above-mentioned prior art. As a result of intensive research as a target, they found that the intended purpose can be achieved by press-fitting titanium oxide spheres or spheres coated with titanium oxide on the substrate, and hydroxyapatite spheres, and completed the present invention. I came to. In view of the above, an object of the present invention is to provide an economically useful germ propagation preventive body that is mainly energy-saving and can safely prevent germ propagation, and a germ reproduction prevention composite material useful as a biomaterial. It is.
【０００４】[0004]
【課題を解決するための手段】上記課題を解決するため
の本発明、基板に酸化チタン球状体または酸化チタンを
被覆した球体を圧入したことを特徴とする雑菌繁殖防止
体、である。また、本発明の他の態様は、基板に酸化チ
タン球状体または酸化チタンを被覆した球体、および／
またはハイドロキシアパタイト、ＴＣＰ、リン酸カルシ
ウム球体を圧入したことを特徴とする雑菌繁殖防止複合
材料および生体材料、である。また、本発明の他の態様
は、基板に効果のことなる２種類以上の球体を圧入した
雑菌繁殖防止複合材料および生体材料、である。さら
に、本発明は、基板に酸化チタン、ハイドロキシアパタ
イト、ＴＣＰ、リン酸カルシウム、消炎剤等の２種類以
上の球体を圧入した前記の雑菌繁殖防止複合材料および
生体材料、を望ましい態様としている。Means for Solving the Problems The present invention for solving the above-mentioned problems is directed to a body for preventing the propagation of various bacteria, characterized in that a titanium oxide sphere or a sphere coated with titanium oxide is press-fitted into a substrate. Further, another embodiment of the present invention relates to a titanium oxide sphere or a sphere coated with titanium oxide on a substrate, and / or
Or a composite material for preventing bacterial growth and a biomaterial, wherein hydroxyapatite, TCP, and calcium phosphate spheres are press-fitted. Another aspect of the present invention is a composite material for preventing germ propagation and a biomaterial in which two or more types of spheres having different effects are pressed into a substrate. Further, the present invention has a desirable embodiment of the above-mentioned composite material for preventing reproduction of various germs and a biomaterial, in which two or more kinds of spheres such as titanium oxide, hydroxyapatite, TCP, calcium phosphate, and an anti-inflammatory agent are pressed into a substrate.
【０００５】上記の目的は本発明によれば、基板に酸化
チタン球状体または酸化チタンを被覆した球状セラミッ
クス等の球体、および／またはハイドロキシアパタイ
ト、ＴＣＰ、リン酸カルシウム等の球体を圧入すること
によって達成される。本発明の雑菌繁殖防止体および雑
菌繁殖防止複合材料の作用について説明すれば以下の通
りである。本発明による雑菌繁殖防止体をプールの内側
に張ったり、あるいは飲料水などを容れた容器に入れて
置けば、ハイドロキシアパタイトが雑菌を吸着し太陽光
や電灯の光を受けて、酸化チタンに電子や正孔が生成し
て酸化還元を行うため、その作用により雑菌の繁殖を防
止できる。酸化チタンの粉末を用いる場合に比べ回収が
容易である。また本発明による雑菌繁殖防止複合材料を
人工歯根や人工歯冠に用いれば虫歯菌をハイドロキシア
パタイトが吸着し酸化チタンが菌の繁殖を防止する。ま
た人工骨ではこの基板を用いれば手術時に付着した雑菌
の繁殖を酸化チタンにより防止できる。ＴＣＰやハイド
ロキシアパタイトを圧入した基板では骨欠損部に埋入す
ることで新生骨と早期に結合する。また球体が剥離する
ことがない。ＴＣＰは初期固定に優れハイドロキシアパ
タイトは長期の固定に優れるので、ＴＣＰとハイドロキ
シアパタイトを交互にまたは混合して圧入したものは初
期固定が早く長期の固定も強固である。さらに酸化チタ
ンと併せて３種を圧入したものは雑菌の繁殖もおさえら
れ好ましい。According to the present invention, the above objects can be attained by press-fitting a sphere such as a titanium oxide sphere or a spherical ceramic coated with titanium oxide and / or a sphere such as hydroxyapatite, TCP, or calcium phosphate on a substrate. You. The action of the germ growth inhibitor and the germ prevention composite material of the present invention will be described below. If the antibacterial growth inhibitor according to the present invention is stretched inside a pool or placed in a container containing drinking water, etc., hydroxyapatite adsorbs the germs and receives the light of sunlight or an electric light to convert the titanium oxide into titanium oxide. Oxygen and holes are generated and redox is performed, so that the propagation of various bacteria can be prevented by the action. Recovery is easier than when using titanium oxide powder. When the composite material for preventing bacterial growth according to the present invention is used for an artificial tooth root or an artificial tooth crown, hydroxyapatite adsorbs caries and titanium oxide prevents bacterial growth. In addition, in the case of artificial bone, the use of this substrate can prevent the propagation of various bacteria attached during surgery with titanium oxide. In a substrate into which TCP or hydroxyapatite is press-fitted, the substrate is early bonded to the new bone by being embedded in a bone defect. Also, the sphere does not peel off. Since TCP is excellent in initial fixation and hydroxyapatite is excellent in long-term fixation, those in which TCP and hydroxyapatite are alternately or mixed and injected are quick in initial fixation and strong in long-term fixation. Further, it is preferable to press-inject three kinds together with titanium oxide, because the propagation of various bacteria can be suppressed.
【０００６】[0006]
【発明の実施の形態】次に、本発明についてさらに詳述
する。本発明において、基板の材質は、必要な強度を持
ち加熱下で球体に圧入できる程度の塑性変形があればガ
ラス、プラスチック、金属、セラミックス等何でもよ
い。具体的には、基板としては、例えば、チタンやチタ
ン合金、ステンレス等の金属、ほう珪酸ガラス、ソーダ
石灰ガラス、シリカガラス等が好ましい。基板の形状
は、角柱、円柱状、球状、板状、等どのような形状でも
よい。また基板が閉じた形であっても、ふたがあっても
なくてもよく、円管状や角管状であってもよい。Next, the present invention will be described in more detail. In the present invention, any material such as glass, plastic, metal, and ceramics may be used as the material of the substrate as long as it has the required strength and has a plastic deformation that can be pressed into a sphere under heating. Specifically, as the substrate, for example, metals such as titanium, titanium alloy, stainless steel, borosilicate glass, soda-lime glass, and silica glass are preferable. The shape of the substrate may be any shape such as a prism, a cylinder, a sphere, a plate, and the like. Further, the substrate may have a closed shape, may or may not have a lid, and may have a circular or square tube shape.
【０００７】本発明に用いる酸化チタン球状体として
は、粒状体の光触媒酸化チタンが好適に使用され、ま
た、酸化チタンを被覆した球体としては、酸化チタン薄
膜を形成した球体が使用される。上記酸化チタン薄膜
は、四塩化チタンとアルコールとの反応によって得られ
るチタンのアルコキシドからチタニアゾルを作り、これ
をディップコーティング法やスピンコーティング法、塗
布法、スプレー熱分解法等によって球体にコートしたの
ち、焼成して製作してもよいし、チタン製の球体をガス
炎などで加熱、酸化してもよい。また超微粒子の酸化チ
タンの縣濁液を、ディップコーティング法やスピンコー
ティング法、塗布法、スプレー法などによって球体にコ
ートしたのち焼成してもよい。その際の焼成温度は４０
０℃〜７００℃、特に、５００℃程度が好ましい。この
場合、４００℃を下回ると酸化チタンが光触媒として活
性化するアナターゼ（ａｎａｔａｓｅ）結晶にならない
こと、また、７００℃を上回るとルチル（ｒｕｔｉｌ
ｅ）型結晶になってしまうことから、上記の温度範囲と
することが必要とされる。本発明に用いる酸化チタンを
被覆するための球体は、セラミックス、金属、プラスチ
ック等５００℃で焼成でき、基板に圧入できる程度の強
度があるものであればなんでもよい。具体的には、球体
としては、例えば、アルミナやジルコニア、ガラス、チ
タン、ハイドロキシアパタイト、ＴＣＰ（リン酸三カル
シウム）、リン酸カルシウム、ディオプサイド、ウオラ
ストナイトなどが好適なものとして例示される。また、
上記球状体および球体の大きさは、１μｍから５ｍｍ、
好ましくは１０μｍから１ｍｍ、さらに好ましくは１０
μｍから０．５ｍｍが適当である。この場合、上記の範
囲より小さいと均一に圧入するのが難しくなり、また、
上記の範囲より大きいと、５０％以上圧入するのが難し
くなる。As the titanium oxide sphere used in the present invention, a particulate photocatalytic titanium oxide is preferably used, and as the sphere coated with titanium oxide, a sphere formed with a titanium oxide thin film is used. The titanium oxide thin film is made of a titania sol from an alkoxide of titanium obtained by a reaction between titanium tetrachloride and an alcohol, and after coating this on a sphere by dip coating, spin coating, coating, spray pyrolysis, or the like, It may be manufactured by firing, or a titanium sphere may be heated and oxidized by a gas flame or the like. Alternatively, a suspension of ultrafine titanium oxide may be coated on a sphere by a dip coating method, a spin coating method, a coating method, a spray method, or the like, and then fired. The firing temperature at that time is 40
0 ° C to 700 ° C, particularly preferably about 500 ° C. In this case, when the temperature is lower than 400 ° C., the titanium oxide does not become an anatase crystal activated as a photocatalyst, and when the temperature exceeds 700 ° C., rutile is used.
e) Since it becomes a type crystal, it is necessary to set the temperature in the above range. The sphere used for coating the titanium oxide used in the present invention may be any ceramic, metal, plastic, or the like that can be fired at 500 ° C. and has such a strength that it can be pressed into a substrate. Specifically, examples of suitable spheres include alumina, zirconia, glass, titanium, hydroxyapatite, TCP (tricalcium phosphate), calcium phosphate, diopside, and wollastonite. Also,
The size of the sphere and the sphere is 1 μm to 5 mm,
Preferably 10 μm to 1 mm, more preferably 10 μm
A range from μm to 0.5 mm is appropriate. In this case, if it is smaller than the above range, it is difficult to press-fit uniformly, and
If it is larger than the above range, it is difficult to press-fit 50% or more.
【０００８】圧入方法は上記球状体または球体を基板に
シリコングリース、グリセリンなどにより付着させ、基
板が塑性変形を起こす温度に加熱し加圧して行う。加熱
と加圧はホットプレス等を用いて行えばよい。金属基板
を用いるときは酸化防止のため真空ホットプレスを用い
るのがよい。圧入は上記球状体または球体の５０％以
上、例えば、５０〜６０％まで行うのが好ましい。ガラ
スでは加熱により軟化するので加圧しなくても球体の自
重で圧入できる場合がある。In the press-fitting method, the sphere or the sphere is adhered to the substrate with silicon grease, glycerin, or the like, and the substrate is heated and pressed to a temperature at which the substrate is plastically deformed. Heating and pressing may be performed using a hot press or the like. When using a metal substrate, a vacuum hot press is preferably used to prevent oxidation. The press-fitting is preferably carried out at 50% or more, for example, 50 to 60% of the sphere or sphere. Since glass softens when heated, it may be possible to press-fit it under its own weight without pressing.
【０００９】こうして得られた雑菌繁殖防止体をプール
等の内側に張ったり、飲料水などを容れた容器に入れて
おけば、ハイドロキシアパタイトが雑菌を吸着しさらに
太陽光や電灯などの光をうけて酸化チタンに電子や正孔
が生成して酸化還元を行い、その作用により雑菌の繁殖
を防止できるため、プール等の底や壁、タイルなどにぬ
めりがついてすべるのを防止できる。また、同様に得ら
れた雑菌繁殖防止複合材料を人工歯根として用いれば虫
歯菌の繁殖を防止することができる。人工骨に用いれば
手術による雑菌を殺菌できる。またハイドロキシアパタ
イトやＴＣＰ、リン酸カルシウムなどにより骨との親和
性がよくなる。また人工骨には消炎剤を混合すれば手術
による炎症を防止することもできる。特にこの発明は、
例えば、酸化チタンとハイドロキシアパタイト、ハイド
ロキシアパタイトとＴＣＰ、消炎剤などの作用効果の異
なる２種類以上の球体を交互にまたは混合して圧入する
ことができるので、いままでにない優れた複合材料を提
供できる。この場合、前述の球状体または球体、他の適
宜の薬剤等の球体を適宜組合わせて使用することが可能
である。If the thus-obtained anti-bacterial propagation body is stretched inside a pool or the like or placed in a container containing drinking water or the like, hydroxyapatite adsorbs the germs and is further exposed to sunlight or electric light. Electrons and holes are generated in the titanium oxide to perform oxidation-reduction, and the action of the redox can prevent the growth of various bacteria. Therefore, it is possible to prevent the bottom, walls, tiles, and the like of the pool from slipping due to slime. In addition, the use of the obtained composite material for preventing bacterial growth as an artificial tooth root can prevent the growth of dental caries. When used for artificial bones, various bacteria due to surgery can be sterilized. In addition, hydroxyapatite, TCP, calcium phosphate and the like improve affinity with bone. If an anti-inflammatory agent is mixed with the artificial bone, inflammation due to surgery can be prevented. In particular, the invention
For example, two or more kinds of spheres having different effects such as titanium oxide and hydroxyapatite, hydroxyapatite and TCP, and an anti-inflammatory agent can be alternately or mixed and press-fitted, thereby providing an unprecedented excellent composite material. it can. In this case, the above-mentioned spheres or spheres and spheres such as other appropriate drugs can be appropriately used in combination.
【００１０】次に、実施例に基づいて本発明を具体的に
説明するが、本発明は当該実施例によって何ら限定され
るものではない。Next, the present invention will be specifically described based on examples, but the present invention is not limited to the examples.
実施例１ ＺＮ−ＡＬ系合金（ＳＰＺ、三井金属鉱業社製）の５０
×５０×３０ｍｍの試験片の表面に光触媒酸化チタン粒
状体（粒径０．５ｍｍ）を静置し垂直に荷重をくわえて
酸化チタンを合金に埋め込んだ。埋め込み時の温度は２
５０℃で応力は１．５ＭＰａとした。その結果酸化チタ
ンは約７０％圧入されていた。これを太陽光のもとコッ
プに水とともにいれて３ヶ月放置したが藻等の発生は観
察されなかった。Example 1 50 of ZN-AL alloy (SPZ, manufactured by Mitsui Mining & Smelting Co., Ltd.)
A titanium oxide photocatalyst (particle diameter: 0.5 mm) was allowed to stand on the surface of a test piece of × 50 × 30 mm, and a titanium oxide was embedded in the alloy by applying a load vertically. The temperature at the time of implantation is 2
At 50 ° C., the stress was 1.5 MPa. As a result, about 70% of titanium oxide was injected. This was put in a glass with water under sunlight and left for 3 months, but no generation of algae and the like was observed.
【００１１】実施例２ ゾルゲル法により作製した酸化チタンをディップコーテ
ィング法によりアルミナの直径約１００ミクロンの顆粒
にコーティングし５５０℃焼成した。これを３回繰り返
した。この顆粒を同型状のハイドロキシアパタイトとと
もに直径１０mm、厚さ２mmのチタン合金板上にシリコン
グリースを用いて付着した。これに７２５℃の真空下で
１０分間、２０Kgの加重をかけ顆粒を圧入した。その結
果、顆粒は５０−６０％圧入されていた。これを金魚鉢
に水とともに２０個入れて蛍光灯下で一ヶ月放置した
が、その表面にぬめりは生じず、雑菌や藻も生えてこな
かった。雑菌繁殖防止体を入れない場合は一週間で藻が
はえてぬめりが生じた。Example 2 Titanium oxide prepared by a sol-gel method was coated on alumina granules having a diameter of about 100 μm by a dip coating method and fired at 550 ° C. This was repeated three times. The granules were adhered to the same type of hydroxyapatite on a titanium alloy plate having a diameter of 10 mm and a thickness of 2 mm using silicon grease. The granules were pressed under a vacuum of 725 ° C. for 10 minutes with a weight of 20 kg. As a result, the granules were 50-60% pressed. Twenty of these were put in a fishbowl together with water and left for one month under a fluorescent lamp, but no slime was formed on the surface and no germs or algae grew. Without the anti-bacterial growth inhibitor, the algae grew in one week, causing slime.
【００１２】実施例３ ハイドロキシアパタイトとＴＣＰの直径約１００ミクロ
ンの顆粒を混合し、直径１０mm、厚さ２mmのチタン合金
板上にシリコングリースを用いて付着した。これに７２
５℃の真空下で１０分間、２０Kgの加重をかけ顆粒を圧
入した。その結果、顆粒は５０−６０％圧入されてい
た。これを家ウサギの骨欠損部に埋入したところ３ヶ月
で新生骨と直接結合した。顆粒のはがれはまったくなか
った。EXAMPLE 3 Hydroxyapatite and TCP granules having a diameter of about 100 μm were mixed and attached to a titanium alloy plate having a diameter of 10 mm and a thickness of 2 mm using silicon grease. 72
The granules were pressed under a vacuum of 5 ° C. for 10 minutes with a weight of 20 kg. As a result, the granules were 50-60% pressed. When this was implanted into a bone defect in a domestic rabbit, it was directly bonded to the new bone in 3 months. There was no peeling of the granules.
【００１３】実施例４ ゾルゲル法により作製した酸化チタンをディップコーテ
ィング法によりアルミナの直径約１００ミクロンの顆粒
にコーティングし５５０℃で焼成した。これを３回繰り
返した。この顆粒と直径約１００ミクロンのハイドロキ
シアパタイト顆粒を直径１０mm、厚さ２mmのチタン合金
板上にシリコングリースを用いて付着した。これに７２
５℃の真空下で１０分間、２０Kgの加重をかけ顆粒を圧
入した。その結果、顆粒は５０−６０％圧入されてい
た。これを太陽光のもと水中に入れておいたところ水は
透明のままで雑菌もほとんど検出されなかった。雑菌繁
殖防止体を入れなかった場合は水が白く濁って雑菌が繁
殖した。Example 4 Titanium oxide produced by the sol-gel method was coated on alumina granules having a diameter of about 100 μm by dip coating and fired at 550 ° C. This was repeated three times. The granules and hydroxyapatite granules having a diameter of about 100 μm were adhered to a titanium alloy plate having a diameter of 10 mm and a thickness of 2 mm using silicon grease. 72
The granules were pressed under a vacuum of 5 ° C. for 10 minutes with a weight of 20 kg. As a result, the granules were 50-60% pressed. When this was put in water under sunlight, the water remained transparent and almost no germs were detected. In the absence of the germ-inhibiting body, the water became white and turbid, and germs grew.
【００１４】[0014]
【発明の効果】以上詳述したように、本発明は、基板に
酸化チタン球状体または酸化チタンを被覆した球体、お
よび／またはハイドロキシアパタイト球体等を圧入した
ことを特徴とする雑菌繁殖防止体および雑菌繁殖防止複
合材料に係るものであり、本発明によれば、省エネルギ
ー的でかつ安全に雑菌の繁殖を防止することが可能な雑
菌繁殖防止体および雑菌繁殖防止複合材料を提供するこ
とができる。本発明の上記雑菌繁殖防止体は、例えば、
プール、水槽等における雑菌繁殖の防止材料として、ま
た、上記雑菌繁殖防止複合材料は、例えば、人工歯根や
人工歯冠、人工骨の材料などとして、有用である。As described in detail above, the present invention relates to an antibacterial growth inhibitor characterized in that a titanium oxide sphere or a sphere coated with titanium oxide and / or a hydroxyapatite sphere is pressed into a substrate. The present invention relates to a composite material for preventing germ propagation, and according to the present invention, it is possible to provide a germ reproduction inhibitor and a germ reproduction prevention composite material that are energy-saving and can safely prevent germ propagation. The bacterium propagation inhibitor of the present invention, for example,
The composite material for preventing bacterial growth in pools, aquariums, and the like, and the composite material for preventing bacterial growth are useful, for example, as materials for artificial roots, artificial crowns, and artificial bones.
【図１】本発明の雑菌繁殖防止複合材料の一実施例を示
す説明図である。FIG. 1 is an explanatory view showing one embodiment of the composite material for preventing germ propagation of the present invention.
ａ ハイドロキシアパタイト球体 ｂ ＴＣＰ球体 ｃ 基板（チタン合金） a hydroxyapatite sphere b TCP sphere c substrate (titanium alloy)
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.6 識別記号 ＦＩ Ｃ２２Ｃ 1/10 Ｃ２２Ｃ 1/10 Ｚ // Ａ０１Ｎ 25/08 Ａ０１Ｎ 25/08 ──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. 6 Identification symbol FI C22C 1/10 C22C 1/10 Z // A01N 25/08 A01N 25/08
Claims (4)
ンを被覆した球体を圧入したことを特徴とする雑菌繁殖
防止体。An antibacterial propagation body, characterized in that a titanium oxide sphere or a sphere coated with titanium oxide is pressed into a substrate.
ンを被覆した球体、および／またはハイドロキシアパタ
イト、ＴＣＰ、リン酸カルシウム球体を圧入したことを
特徴とする雑菌繁殖防止複合材料および生体材料。2. A composite material and biomaterial for preventing propagation of various bacteria, wherein a titanium oxide sphere or a sphere coated with titanium oxide and / or hydroxyapatite, TCP, and calcium phosphate sphere are pressed into a substrate.
球体を圧入した雑菌繁殖防止複合材料および生体材料。3. A composite material for preventing the growth of various bacteria and a biomaterial, into which two or more types of spheres having different functions and effects are pressed into a substrate.
イト、ＴＣＰ、リン酸カルシウム、消炎剤等の２種類以
上の球体を圧入した請求項３記載の雑菌繁殖防止複合材
料および生体材料。4. The composite material and biomaterial of claim 3, wherein two or more types of spheres such as titanium oxide, hydroxyapatite, TCP, calcium phosphate, and an anti-inflammatory agent are pressed into the substrate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8307210A JP2920204B2 (en) | 1996-10-31 | 1996-10-31 | Bacterial growth prevention composite material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8307210A JP2920204B2 (en) | 1996-10-31 | 1996-10-31 | Bacterial growth prevention composite material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH10130112A true JPH10130112A (en) | 1998-05-19 |
| JP2920204B2 JP2920204B2 (en) | 1999-07-19 |
Family
ID=17966374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8307210A Expired - Lifetime JP2920204B2 (en) | 1996-10-31 | 1996-10-31 | Bacterial growth prevention composite material |
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| Country | Link |
|---|---|
| JP (1) | JP2920204B2 (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2000010706A1 (en) * | 1998-08-21 | 2000-03-02 | Ecodevice Laboratory Co., Ltd. | Visible radiation type photocatalyst and production method thereof |
| KR100431159B1 (en) * | 2001-03-22 | 2004-05-12 | 김철생 | Method for producing Ti-based implant having bioactive surface as substitute for bone tissue |
| JP2006280564A (en) * | 2005-03-31 | 2006-10-19 | Fukuoka Prefecture | Ceramic scaffold with metal surface modification and its use |
| JP2007014686A (en) * | 2005-07-11 | 2007-01-25 | Univ Kinki | Biomaterial, medical material using the same, and method for producing the material for organism |
| JP4576026B2 (en) * | 2000-06-22 | 2010-11-04 | 富田製薬株式会社 | Disinfectant and disinfecting method |
| JP2014534141A (en) * | 2011-08-31 | 2014-12-18 | シャンハイ ワールド−プロスペクト ケミテック カンパニーリミテッド | Inorganic nonmetallic mineral composite material carrying titanium dioxide layer, production method and application |
| JP2018020310A (en) * | 2016-07-20 | 2018-02-08 | 学校法人梅村学園 | Photocatalystic composite and manufacturing method therefor |
| JP2018110557A (en) * | 2017-01-12 | 2018-07-19 | 学校法人近畿大学 | Plant affinity material and use thereof |
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| JP2007014686A (en) * | 2005-07-11 | 2007-01-25 | Univ Kinki | Biomaterial, medical material using the same, and method for producing the material for organism |
| JP2014534141A (en) * | 2011-08-31 | 2014-12-18 | シャンハイ ワールド−プロスペクト ケミテック カンパニーリミテッド | Inorganic nonmetallic mineral composite material carrying titanium dioxide layer, production method and application |
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| JP2018110557A (en) * | 2017-01-12 | 2018-07-19 | 学校法人近畿大学 | Plant affinity material and use thereof |
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