JPH10123128A - Solid agent for urine protein examination and washing in flush toilet and its use method - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a solid agent for examining and washing urine protein for a flush toilet for enabling one's health condition to be checked for a long time easily and visually and at the same time enabling a toilet stool to be washed in a general home flush toilet. SOLUTION: A solid agent for examining and washing urine protein and being used for washing water in a flush toilet water tank consists of a solid forming object that contains pH indicator that is discolored according to the amount of protein in urine, a buffer agent, a detergent, and a dissolution speed- adjusting agent for suppressing the underwater degree of dissolution of the above buffer agent and the detergent. Using the pH indicator, the washing water of a flush toilet water storage tank that contains the pH indicator and a detergent constituent that are eluted from the above solid forming object into water indicates yellow color. However, when it is mixed with normal protein, the color stays yellow without any discoloration. When it is mixed with a low-degree protein urine, the color changes to green. Also, when it is mixed with a high-degree protein urine, the color changes to blue in terms of color development change characteristics.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a flush toilet which can supply a cleaning agent in a water tank of a flush toilet with an indicator and a buffer which can be discolored in accordance with the amount of protein and the amount of protein for a long period of time. At the same time as washing the urine, the change in the color of the pH indicator in the washing water that comes into contact with the excreted urine allows the visual check of the amount of protein in the urine to allow the human health condition to be constantly checked in daily life The present invention relates to a solid preparation for urine protein test and cleaning used in a flush toilet water tank and a method of using the same, which is characterized by the above.

[0002]

2. Description of the Related Art Conventionally, various tests of urine have been carried out in medical facilities and the like as part of diagnosis of diseases. Excreted urine protein can also be checked for many diseases. A small amount (40-80 mg / day) of protein is excreted in urine even in a healthy person, but is not detected by a usual protein qualitative test. However, if the excreted urine becomes persistent proteinuria (30 mg / dl or more) due to any etiology, nephritis, pyelonephritis, cystitis, nephrosis, diabetic nephropathy, heart failure, hemolytic disease, collagen disease, fever , Toxic diseases, overwork, etc. are considered as one of the factors.

[0003] At present, three methods of protein testing of urine are used: a test paper method, a sulfosalicylic acid method, and a boiling method. Of these, the test paper method is the most widespread, and the other two methods are used to check the results by the test paper method. This test paper method utilizes the fact that, when measuring the pH of a solution with a pH indicator, if a protein is present in the solution, the free amino groups of the protein molecules are combined with the pH indicator to form a color. This test strip contains tetrabromophenol blue as an indicator,
Citrate is included as a buffer. The test sample urine in the reaction area of the test paper is maintained at pH 3 by this buffer, but when proteins are contained, the color change point of tetrabromophenol blue changes from pH 3 to 4 to pH 2 to 3 and turns blue, and from this color tone the protein Is understood.

[0004] However, in order to carry out this test strip method in ordinary households, a test strip must be prepared each time.

[0005] In addition to the above, various methods as described below have been proposed.

(1) A water-soluble urine screening reagent for dispensing flush water containing a discoloration indicator and a cleaning agent that changes for at least one of pathological components in excreted urine (solution type)
Is known (JP-A-62-177450).
However, it is necessary to drop this reagent solution into the puddle of the toilet every time urination occurs, and it is necessary to adjust the amount of the reagent to be added to the flushing water tank of the toilet with a special device so as to have a constant concentration.

(2) An insect repellent and a pH indicator, bromothymol blue and methyl red, are thoroughly mixed,
It is a molded mixture, which is put in the toilet bowl, and at the time of urination, the pH indicator takes on the color of the pH at that time due to contact with the excreted urine. An inspection ball that can be known is known (Japanese Patent Laid-Open No. 48-104380).

[0008] (3) In the depression of the toilet bowl where urination stays,
Immediately before or after small use, immerse the test paper or add test reagents (for pH, protein, glucose, ketone bodies, occult blood, urobilinogen, etc.) to remove the urine without collecting urine in a separate container. A urine test method using a urine collection container as it is is known (JP-A-59-40256).

(4) Among the various components contained in urine, a test reagent capable of detecting the concentration of at least one of sugar and protein discharged by a color reaction is mixed with an easily water-soluble solid agent. A urine test reagent is known (Japanese Utility Model Laid-Open No. 4-136569).

(5) Among the urine-containing components, a test reagent capable of detecting the excretion concentration of at least one of sugar and protein by a color reaction is coated with a poorly water-soluble coating. Characterized in that the in-membrane reagent is eluted out of the membrane by excreted urine,
A coated tablet-type urine test reagent is known (Jpn.
8464).

(6) A tank cleaner composition to be put into washing water in a washing toilet water tank, wherein a blue or green dye for giving a blue or green color to the washing water can be arbitrarily compounded or colorless. A solid cleaner composition containing a detergent, a fragrance, a deodorant, and a disinfectant is commercially available under the trade name "Bluelet Dobon"["Chemistry", Vol. 48, No. 3, pp. 154-157 (1993).
Year)].

[0012]

In a flush toilet in a general household, the user can easily check his / her own health condition at the time of urinary excretion without requiring any troublesome operation or equipment, and can simultaneously clean the toilet. The present inventor has conceived that providing a solid preparation for testing and cleaning urine proteins for flush toilets that has been devised in such a manner would be beneficial to human daily life.

[0013]

Means for Solving the Problems The present inventors have conducted various studies to solve the above-mentioned problems. As a result, it contains a known colored pH indicator and a surfactant-type cleaning agent. If a solid preparation can be prepared so that these can be gradually eluted, the solid preparation is washed with water for washing in a water tank of a flush toilet. By throwing in the toilet, when the flush water is flushed from the flush toilet tank when using the toilet, the toilet can be washed with the flush water containing the detergent eluted in the flush water,
The pH indicator in the washing water and the excreted urine come into contact with each other in the puddle of the toilet bowl to react and visually check the discoloration of the pH indicator. The present inventor has found that it is possible to always observe in daily life without doing so.

[0014] Further research has been made to select from among a number of known pH indicators the type of colored pH indicator suitable for incorporation into the solid dosage form for the above uses, and for both pH indicators and detergents. A dissolution rate regulator capable of appropriately suppressing the dissolution rate in water, that is, an appropriate type of sustained-release agent was successfully selected. The present invention has been completed based on many findings obtained in these studies.

Accordingly, in the first aspect of the present invention, a pH indicator, a buffer, and a detergent which discolor according to the amount of protein in urine contacted with the solid preparation, and the pH indicator, the buffer and the detergent are used. A water-soluble toilet comprising a solid molded product containing a dissolution rate regulator that suppresses solubility in water, and wherein the pH indicator contains a pH indicator, a buffer, and a detergent component eluted from the solid molded product into water. The washing water in the water tank shows yellow, but when the protein is present in the urine, the colored water is of a type showing a color change characteristic in which the free amino group of the protein molecule is combined with a pH indicator to turn blue. There is provided a solid preparation for urine protein test / washing, which is used by being introduced into washing water in a flush toilet cistern.

Next, the solid preparation for testing and washing urine according to the first invention will be described in detail.

The pH indicator contained in the solid preparation of the present invention is a pH indicator that changes from yellow to yellowish green to green to blue so that the discoloration caused by the amount of protein in urine can be distinguished sharply. Is suitable. Particularly preferred is sodium tetrabromophenol blue, disodium tetrabromophenol blue, sodium tetrabromophenolphthalein or disodium tetrabromophenolphthalein represented by the following formula. All of these are easy to mix in a solid preparation in the form of a sodium salt (powder), and it is easy to adjust solidification and sustained release.

[0018]

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[0019]

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The content of these pH indicators in the solid preparation is about 1 to 30% by weight, but it is preferably about 2 to 10% by weight in view of the functionality of the solid preparation of the present invention. preferable.

The buffer contained in the solid preparation of the present invention is not particularly limited as long as it can maintain the pH of the test urine at 3. For example, citric acid, gluconic acid, succinic acid, lactic acid, fumaric acid, malic acid, glucono delta lactone, oxalic acid, glycolic acid, organic acids such as sulfamic acid, ethylenediaminetetraacetic acid, acetic acid, or hydrochloric acid, phosphoric acid, sulfuric acid, etc. And salts thereof such as alkali metals, ammonium and lower alkanolamines. Organic acids are preferred from the viewpoints of safety to living organisms, irritation and environmental pollution. In particular, the solid preparation according to the present invention preferably contains both citric acid and sodium citrate.

These mixing ratios are 1:10 to 1 by weight.
It can be arbitrarily adjusted within the range of 0: 1, but the weight ratio is 5: 1.
A range of １1: 1 is preferred. The total content of these two components in the solid preparation is about 1 to 30% by weight,
The content is preferably in the range of about 2 to 20% by weight in view of the functionality of the solid preparation of the present invention.

The detergent contained in the solid preparation of the present invention, that is, the surfactant, is not particularly limited as long as it does not adversely affect the discoloration of the pH indicator. Among them, it is particularly preferable that each of the nonionic surfactant and the anionic surfactant is used alone or as a mixture.

Examples of the nonionic surfactant include polyoxyethylene alkyl ether, polyoxyethylene alkyl aryl ether, polyoxyethylene alkyl aryl ether / formaldehyde condensate, polyoxyalkylene aryl ether, polyoxyalkylene alkyl ester, Polyoxyalkylene alkyl sorbitol ester, polyoxyalkylene sorbitan ester, polyoxyalkylene alkyl glycerol ester, polyoxyalkylene block copolymer, alkyl glycerol ester, polyoxyalkylene alkyl sulfonamide, polyoxyalkylene rosin ester, polyoxypropylene block copolymer Polymer, polyoxyethylene oleyl ether, polyoxyalkylene alkylpheno , Alkyl glucooxide, alkyl polyglycoside, polyoxyalkylene alkyl polyglycoside, polyoxyethylene glycol monostearic acid ester, polyoxyethylene cetyl alcohol, and the like, and mixtures of two or more thereof. Can be

As the nonionic surfactant, a polyhydric alcohol ester and / or an alkylene oxide adduct of the polyhydric alcohol ester is particularly preferable.
Here, glycerin or sorbitan is preferable as the polyhydric alcohol, and ethylene oxide is preferable as the alkylene oxide to be added.

Typical of the anionic surfactants are sodium mono- and di-alkylnaphthalenesulfonates, sodium alpha-olefinsulfonate, sodium alkanesulfonates, alkylsulfosuccinates, alkylsulfates, Polyoxyalkylene alkyl ether sulfate, polyoxyalkylene alkyl aryl ether sulfate, polyoxyalkylene styryl phenyl ether sulfate, mono- and -di-alkylbenzene sulfonates, alkyl naphthalene sulfonates, formaldehyde condensates of alkyl naphthalene sulfonates , Alkyl diphenyl ether sulfonates, olefinic sulfonates, mono- and -dialkyl phosphates, polyoxyalkylene mono- and dialkyl phosphates, polio Shiarukirenmono and diphenyl ether phosphates, polyoxyalkylene mono- and dialkyl phenyl ether phosphates, polycarboxylates,
Fatty acid salts, linear and branched alkyl polyoxyalkylene ether acetic acids or salts thereof, alkenyl polyoxyalkylene ether acetic acids or salts thereof, linear and branched alkyl amide polyoxyalkylene ether acetic acids or salts thereof, stearic acid and salts thereof, oleic acid And its salts,
N-methyl fatty acid tauride, or two of these
There may be more than one kind or a mixture.

The content of the detergent in the solid preparation of the present invention is as follows:
The amount may be about 30% by weight or more, but is preferably in the range of about 50 to 90% by weight from the viewpoint of storage stability as a solid preparation.

As the dissolution rate regulator contained in the solid preparation of the present invention, esters of ethylene glycol, glycerin, sorbitol, polyglycerin and the like with mono- or polyhydric higher fatty acids or polyoxyalkylene polymers can be used. Two or more can be mixed. Preferably, the dissolution rate modifier is a polyoxyethylene polyoxypropylene block polymer, polyoxyethylene distearate, glycerin monostearate, and triglycerin tristearate. The polyoxyethylene / polyoxypropylene / block polymer melts at a temperature higher than 70 ° C., but preferably has an average molecular weight such that it solidifies at a temperature lower than 70 ° C.

The content of the dissolution rate regulator in the solid preparation of the present invention is 10 to 90% by weight, preferably 20 to 80% by weight.
It is.

In the solid preparation of the present invention, deodorants, fragrances, extenders and other auxiliary components can be blended as optional additives other than the above.

As the deodorant, menthol, camphor,
Naphthalene and p-dichlorobenzene can be used.Flavors to eliminate bad smells, such as compounded fragrances, or sorbic acid,
Substances that react with malodorous components such as dehydroacetic acid, glycolic acid, malic acid, and glyoxal to eliminate malodors are used. As the bulking agent, mainly water-soluble substances such as urea, melamine, acetanilide, glucose, magnesium chloride, borax and the like can be blended.

The solid preparation of the present invention is generally conveniently prepared by a method comprising the following steps (1) and (2).

(1) First Step Each component of the drug substance is put into a container, and the mixture is heated with stirring to melt the whole mixture to a liquid state. In this state, each component of the raw material is sufficiently mixed. The mixing temperature varies depending on the type and composition ratio of the raw material components, but is preferably 70 to 100C.

(2) Second Step The molten liquid mixture is filled into a cup or other mold using a dispenser or the like, and when cooled, solidified at 30 to 70 ° C. to obtain a solid preparation. It can be stored by covering the mold with a film or the like. When a polypropylene cup is used as a mold, the manufactured solid preparation is easily separated from the cup and easily taken out.

The shape of the solid preparation of the present invention can be various shapes such as a cylindrical shape, a spherical shape or a block shape, and if desired, can also be a granular shape. When it is formed into granules, it is used in a mesh bag or a perforated container. The size of a solid preparation such as a cylinder, a sphere or a block is 10 to 120 g per one, preferably 1 to 120 g.
The weight should be between 0 and 60 g.

In the solid preparation of the present invention, the composition of the raw materials is adjusted so as to have a specific gravity heavier than that of water. A solid preparation having a specific gravity heavier than water may be accidentally plugged in the drainage hole of the water tank when it sinks into the water bottom for washing after being put into the flush toilet water tank. In order to prevent this fear, it is preferable to add a means for keeping the solid preparation floating in the washing water pool.

Accordingly, the solid molded product forming the solid preparation according to the present invention is fixed to the floating body giving buoyancy in water with a suitable fixing tool or fixing agent, and the solid molded product and the floating body fixing the solid molded product are fixed to each other. The whole of the combination may be capable of floating in water without sinking to the bottom of the water or having such a buoyancy as to float on the water surface. The float may be an object having a specific gravity lower than water, such as a polystyrene foam or a bladder.

Further, the solid molded product forming the solid preparation according to the present invention contains a large number of air bubbles scattered throughout the inside thereof, and the solid molded product containing the air bubbles has a specific gravity lower than that of water as a whole. This makes it possible to float in water without sinking to the bottom of the water or to have buoyancy in water such that it floats on the water surface. In this case, the solid preparation in which a large number of air bubbles are scattered and contained is formed by injecting a large number of air bubbles with a nozzle into the molten liquid raw material component mixture in the mold in the above-described manufacturing method, and It can be produced by performing a step of rapidly solidifying the mixture by rapid cooling to trap air bubbles in the solidified solid preparation.

The solid preparation according to the first aspect of the present invention is used as follows.

One solid preparation is put into washing water in a flush toilet water tank. After dosing, the pH indicator, buffer and detergent gradually elute into the water in the reservoir and color the water yellow. When the colored water in the water tank is flushed into the flush toilet after urination, a part of the water remains in the puddle of the toilet. The pH indicator in the water in the puddle reacts with the urinated urine, and the color of the yellow water changes to blue when protein is present in the urine, and the degree of color change as shown below You can know the amount of protein and check your health.

Negative (-) is yellow, (±) (trace, 10
~ 20 mg / dl), yellow-green, (+) (30 mg
/ (Dl) shows green, 2 (+) (100 mg / dl) shows blue, and 3 (+) (100 mg / dl or more) shows dark blue.

Further, in the second aspect of the present invention, the solid preparation according to the first aspect of the present invention is poured into washing water in a reservoir of a flush toilet, and a pH indicator, a buffer and a washing agent eluted from the solid preparation are washed out. Drain the yellow wash water containing the ingredients and flush the urine into the flush toilet to flush the toilet, and at the same time, contact the urine accumulated in the puddle of the toilet with the discharged wash water to react. Then, a method of washing a flush toilet and examining urine protein, characterized in that the amount of protein in urine is determined by observing a change in coloration of water in the puddle portion, is provided.

[0043]

BEST MODE FOR CARRYING OUT THE INVENTION

Next, the present invention will be described specifically with reference to examples.

Example 1 Each of the components of the raw materials described below (incorporation in weight%) was placed in a container equipped with a stirring device and heated to about 80 ° C. After mixing the obtained molten liquid mixture for 10 to 30 minutes, the mixture was mixed with a polypropylene cylindrical cup (diameter 20 m).
m). Upon cooling to room temperature, it solidified at about 40 ° C. The solidified solid was removed from the cup to obtain a tan solid preparation for urine protein inspection / washing (30 g per piece) according to the present invention.

[0045]

The above polyoxyethylene polyoxypropylene block polymer has a molecular weight range of 6,000 to 5,
000 and the trade name "Emulgen PP-290"
(Kao Corporation product). Also,
The above polyoxyethylene sorbitan monolaurate is commercially available under the trade name "Reodol Super TW-L120" (a product of Kao Corporation).

Example 2 Each component of the raw materials described below was placed in a container equipped with a stirring device, and the mixture was heated to 80 ° C., and the whole became a molten liquid, which was mixed for 10 to 30 minutes. . The mixed liquid mixture was dispensed into a polypropylene cylindrical cup (diameter: 20 mm) and allowed to cool at room temperature, and solidified to obtain a glossy yellow-brown cylindrical solid preparation (30 g in weight). .

[0048]

The above-mentioned glycerin monostearate has a molecular weight of 358 and the trade name "EXCEL 84"
(Kao Corporation product). The above nonylphenyl ether of polyethylene glycol (n = 10) has a molecular weight of 660 and is commercially available as trade name "Nonipol 100" (product of Sanyo Chemical Industries, Ltd.).

Each of the solid preparations obtained in Examples 1 and 2 was a yellow-brown reddish-brown cylinder (diameter: 20 mm) weighing 30 g per piece, and had a higher specific gravity than water, and sank when poured into water.

Example 3 In the same manner as in Example 1, a molten liquid mixture was prepared from the raw material components in a mold cup. The mixture was allowed to cool, but immediately before solidification was started, air was injected into the mixture through a plurality of injection needles penetrating into the bottom of the cup to form a large number of air bubbles in the molten mixture. Before the air bubbles escaped from the molten mixture, they were quenched in a freezer and solidified. A tan solid formulation containing a large number of air bubbles was obtained. When this was thrown into the water, it floated in the water.

Next, the performance of the solid preparation of the present invention will be illustrated by the following test examples.

Test Example 1 Color change test by protein in urine (1) 200 mg of the solid preparation obtained in Example 1 was placed in a 2-liter Erlenmeyer flask, 1 liter of water was added thereto, and the mixture was stirred. Upon dissolution, a yellow aqueous solution of pH 3 was obtained. 100 ml of this yellow aqueous solution contains normal urine (p
H6.3) Even when 25 ml was added, the aqueous solution remained yellow and did not change color.

(2) On the other hand, normal urine (pH 6.3)
30 mg of albumin [human-derived albumin crystal, manufactured by Tokyo Chemical Industry Co., Ltd.] was added to 0 ml to prepare low proteinuria (+). When 25 ml of this low proteinuria was added to 100 ml of the yellow aqueous solution, it turned green.

(3) Next, 300 mg of the above-mentioned albumin was added to 100 ml of normal urine to prepare highly proteinuria [3 (+)]. When 25 ml of the proteinuria was added to 100 ml of the yellow aqueous solution, it turned dark blue.

(4) Commercial control urine commercially available in 100 ml of the above-mentioned yellow aqueous solution, trade name “Kovatrol 3”
(Ames, 0.2 mg / dl protein) was dissolved in 15 ml of deionized water and added.

(5) On the other hand, 100 m of the above-mentioned yellow aqueous solution
l is a commercially available highly abnormal control urine, trade name "Covatrol 1" (manufactured by Ames, protein amount: 100 to 300 mg /
When dl) was dissolved in 15 ml of deionized water and added, the color changed to deep blue.

As described above, the yellow aqueous solution containing the components eluted in water from the solid preparation of the present invention does not change even when normal urine (protein negative) is added thereto, and the low proteinuria (+) is reduced. When added, the color changes to green, and when advanced proteinuria is added, the color changes to dark blue, so that the amount of abnormal protein in urine can be detected.

Test Example 2 Sustained release test of pH indicator This example is a test for observing the sustained release of the pH indicator from the solid preparation of the present invention.

(1) The yellow-brown cylindrical solid preparation obtained in Example 2 was cut to obtain 8.5 g of a cylindrical solid (height 3).
0 mm and a diameter of 20 mm). This was placed on the bottom of the beaker, 2 liters of water was added and stirred occasionally, and the water gradually turned yellow. One day later, 2 liters of the obtained yellow water was decanted and discarded, and replaced with 2 liters of fresh water. In this state, the color and shape of the cylindrical solid are kept as they are, and they sink into the bottom of the beaker. every day,
This operation was repeated to examine the color, shape, and water color of the solid. Further, a discoloration test with urine when the colored water was mixed with urine was performed. As a result, 14 days later, water (yellow) 2
When the liter is replaced with fresh water, the color of the solid is retained and the shape is slightly deformed, but remains submerged at the bottom of the beaker. After 18 days, the solids dissolve almost completely and become a yellow aqueous solution. The discoloration test with urine using this aqueous solution was good. In this dissolution test, it took 18 days for 8.5 g of the solid to completely dissolve. Only the pH indicator did not elute first.

(2) Further, one cylindrical solid preparation (30 g) obtained in Example 2 was placed in a beaker, 3 liters of water was added, and the mixture was allowed to stand for 2 hours. Discard the yellow colored water from the beaker, add 3 liters of fresh water to the beaker,
Further, the operation of replacing the colored water with 3 liters of fresh water every two hours was continued. As a result, the solid preparation was completely dissolved after a total of 65 repetitions. The yellow water removed each time was normal urine, low proteinuria (+) (30 mg / d
l) or high proteinuria 2 (+) or more (100 mg / dl)
When the sample was mixed with the above sample, the sample showed color changes of yellow (no discoloration), green, and dark blue, respectively, so that the discoloration test with urine was good.

Test Example 3 Hydrostatic test 7.4 g of a solid cut out from the tan solid preparation obtained in Example 1 (cylindrical having a height of 25 mm and a diameter of 20 mm)
Was placed on the bottom of a 3 liter polyvinyl beaker, and 2 liters of room temperature water was added and allowed to stand. Every three hours, the water colored yellow was removed from the beaker by decantation, and when the water exchange operation of adding 2 liters of fresh water was performed ten times, it was recognized that almost all of the solid preparation had been dissolved. 2 liters of yellow water obtained by decantation was put into a puddle of a flush toilet, and when urinating, it remained yellow and did not change color, indicating that the protein in urine was normal. When 80 mg of the above-mentioned albumin was added thereto, it turned blue.

Test Example 4 Validity Period Test One solid preparation of Example 1 (30 g) was put into a washing water pool in a household flush toilet tank dedicated to urination. Healthy subjects urinate in the toilet at an average rate of 5 to 6 times a day for 10 days, and each time the toilet was flushed with yellow water drained from the water tank. In each case, the yellow water in the toilet puddle remained yellow and did not change color, indicating that the urine protein was normal. Even on the last day of the 10-day test, little colored stain was observed on the inner surface of the toilet. Furthermore, the drainage from the water tank was repeated 100 times in total without urinating the toilet, but the water discharged from the water tank kept yellow.

[0064]

When the solid preparation of the present invention is used in a flush toilet, the following effects are obtained. In other words, simply by putting the solid preparation into the flush toilet cistern, the flushing water that has flowed out of the flush pool accumulates in the puddle portion of the toilet bowl, and the degree of discoloration is determined by seeing whether or not this water and urine react and discolor. The self-health condition can be checked easily and for a long time, and at the same time the toilet can be washed.

Claims (8)

[Claims] 1. A pH indicator, a buffer, a detergent, and a pH indicator that change color according to the amount of protein in urine that comes into contact with the solid preparation.
A solid molded product containing an indicator, the buffer and a dissolution rate regulator for suppressing the solubility of the detergent in water; and the pH indicator is a pH indicator eluted from the solid molded product into water, a buffer. The washing water in the flush toilet containing the detergent and detergent components shows yellow, but when this colored water contains protein in urine, the free amino groups of the protein molecules combine with the pH indicator and turn blue. A solid preparation for urine protein testing / washing, which is used to be put into washing water in a flush toilet cistern, which is of a type showing a color change characteristic. 2. The solid preparation according to claim 1, wherein said pH indicator comprises an alkali metal salt of tetrabromophenol blue or an alkali metal salt of tetrabromophenolphthalein. 3. The solid preparation according to claim 1, wherein the buffer contains both citric acid and sodium citrate. 4. The method according to claim 1, wherein the dissolution rate regulator comprises a polyoxyethylene polyoxypropylene block polymer, a polyoxyethylene distearate, a glycerin monostearate, or a triglycerin tristearate. Solid preparation. 5. The solid preparation according to claim 1, wherein the solid molded product forming the solid preparation according to claim 1 has a specific gravity higher than that of water. 6. A solid molded product forming a solid preparation according to claim 1, which is fixed to a floating body which gives buoyancy in water, and which is a combination of the solid molded product and a floating body fixing the solid molded product. The solid preparation according to claim 1, characterized in that the whole is capable of floating in water without sinking to the bottom of the water or having buoyancy in water such that it floats on the surface of water. 7. The solid molded product forming the solid preparation according to claim 1 contains a large number of air bubbles scattered throughout the inside thereof, and the solid molded product containing the air bubbles is totally contained. 2. The solid preparation according to claim 1, wherein the solid preparation has a specific gravity lower than that of water, whereby the solid preparation can float in water without sinking to the bottom of the water or has a buoyancy such that it floats on the water surface. 8. A p which changes color depending on the amount of protein in the urine in contact with it
A solid preparation comprising a solid molded product comprising an H indicator, a buffer, a detergent, and a dissolution rate regulator that suppresses the solubility of the pH indicator, the buffer and the detergent in water, The indicator is a pH indicator eluted in water from the solid molded product, the washing water in the flush toilet tank containing the buffer and the detergent component shows yellow, but when the colored water contains protein in urine, Urine protein testing / washing used in washing water in flush toilet tanks, in which the free amino groups of protein molecules are of a type showing a color change characteristic that changes color to blue by binding to a pH indicator The solid preparation for washing is poured into the washing water in the flush toilet cistern, and the pH indicator eluted from the solid preparation and the yellow washing water containing the buffer and the detergent component are discharged and urinated into the toilet of the flush toilet. Shed later Vessel was washed, At the same time,
The urine accumulated in the puddle portion of the toilet bowl is caused to react by contacting with the discharged washing water, and the amount of protein in the urine is found by observing a change in the coloration of water in the puddle portion, A method of cleaning the flush toilet and urine protein test.