JPS62177450A - Urine screening reagent and testing method thereof - Google Patents

Abstract

PURPOSE:To easily make a urine test at home by throwing a urine screening reagent contg. an indicator which discolors by reacting with the disease components in discharged urine and detergent into the water reservoir part of a toilet bowl and allowing the same to react with the discharged urine thereby discoloring the reagent. CONSTITUTION:The urine screening reagent to be thrown into flushing water of the toilet bowl is obtd. by incorporating the indicator which discolors by reacting with the disease components in the discharged urine and the detergent therein. A mixture composed of a tetrabromphenol, citric acid and sodium citrate is used as the indicator for testing albumin in urine and a mixture composed of glucose oxidase, hydrogen peroxide decomposing enzyme and orthotoluidine is used for testing urinary sugar. Indicators for testing pH and urine occult blood are used in addition to the above-mentioned indicators. The screening reagent is thrown into the water reservoir part of the toilet bowl so that the discharged urine and the reagent react with each other in the bowl to make the discoloration test. The urinator himself is, therefore, capable of making self-diagnosis by testing the components in the urine.

Description

[Detailed Description of the Invention] [Technical Field of Application] This invention provides a reagent for conducting urine screening tests in the course of normal life for healthy people living in general households, the elderly, people receiving home treatment after illness, etc. and test methods using the same.

[Prior art and problems]

Today, there are products widely used in hospitals, public health centers, etc. that are made by impregnating test vapor with a color change indicator and drying it. Wet the test paper,
It is inspected for the presence or absence of discoloration.

However, for those who live a normal life in a public urinary garden, it is troublesome to prepare test paper each time, especially for those who are currently healthy or are insensitive to health, so it may be difficult to prepare test paper each time. No matter how hard you try, continuous testing is nearly impossible, and patients should only seek medical examination and treatment after they notice symptoms, but it may be too late.

In addition, it cannot be said that the rate of regular health checkups is necessarily high at present, and in cases where the urinary values of the pathological factors change suddenly within a short period of a busy schedule, it is difficult to say that the rate of regular health checkups is necessarily high. A once-a-year health check is not enough to provide peace of mind, and unfortunately, especially for middle-aged and elderly people, it does not directly lead to early detection of illness.

[Problems to be solved]

Therefore, in this invention, there is no change in the life of a normal healthy person at home, there is no change in urination during urination, and there is no troublesome operation. The purpose is to provide the market with something that can perform diagnosis and also clean the toilet bowl itself.

[Means to solve the problem]

The present invention has solved the problem by providing a water-soluble toilet flushing water tank screening reagent containing a detergent and a color change indicator system that changes color upon reaction with at least one of the pathological components in excreted urine.

Another invention provides a solid or liquid water-soluble urine screening reagent containing a detergent and a discoloration indicator that changes color by reacting with at least one of the pathological components of excreted urine. The urine is characterized in that a tank is filled with enough children for a color change reaction, post-excreted urine is poured into the toilet bowl, and the pathological components in the excreted urine are reacted with the urine screening reagent in the toilet bowl. The problem was solved by using a screening test method.

Composition of the present reagent 1) There is no particular limitation as long as it is a color change indicator system that causes a color change and exhibits a specific color due to at least one type of color change indicator system that reacts with pathological components in excreted urine.

Therefore, even if a mixed indicator reacts with two or more pathological components, the present invention is the same.

2) Detergent The detergent is not particularly limited as long as it is a nonionic surfactant that is generally known for cleaning bathtubs, toilet bowls, etc., and does not adversely affect the discoloration reaction.

3) Air freshener There is no need to add any of these.

4) Other diluents or excipients Consisting of a mixture of 1), 2), 3) and 4), the reagent may be a water-soluble liquid or a solid (regardless of solid or powder). It's okay.

[Description of the method invention and method of using the reagent of the present invention]

Appropriate amounts of the reagent are sequentially dropped or poured into the toilet flushing water tank of a flush toilet and dissolved in the flushing water.

When the flush toilet is used in a normal manner, the flush water mixed with the reagent of the present invention is sequentially supplied into the toilet bowl, and after use, a predetermined amount of flush water accumulates in the toilet bowl.

Therefore, if a person using a toilet bowl contains pathological components in his or her urine, this will react with the cleaning water containing the reagent in the toilet bowl, and the urine will develop a color, making it possible to detect abnormalities in one's own urine. After the color develops, flush the flushing water as you would a normal flush toilet. The same operation is performed even when no color reaction occurs.

〔effect〕

As mentioned above, in the method of the present invention, if a device is installed that allows the reagent to be dropped or poured into the wash water tank in small quantities, the toilet bowl itself can be used in exactly the same manner as in normal usage, and the above-mentioned Since the detergent promotes the dispersion effect of urine and causes a rapid color reaction in the toilet bowl, the user of the toilet can know the result by himself/herself.

In addition, regardless of the presence or absence of a reaction, the excrement in the toilet bowl will be flushed away by the detergent and flush water contained in it, and the next flush water that is supplied and collected in the toilet bowl will be A color reaction does not occur unless the pathological components of the drug are mixed.

Further, the product invention of this application can be used for the above-mentioned method invention, and produces effects similar to those of the method invention.

In this way, when a positive or false positive reaction is discovered,
Having a precise measurement performed at a specialized institution will greatly help in early treatment of the disease.

In order to facilitate understanding of the present invention, examples will now be described in detail below.

Example 1 When performing a urine protein test 1. Color change indicator An indicator that reacts with protein, which is a type of pathological component in urine, is Wash Water II! Per 1) Tetrabromophenol blue ・・・・・・・・・ 0.24W++) Citric acid ・・・・・・・・・ 0.4
8My111) Sodium citrate...
...0.3M2] Detergent nonionic surfactant (neutral) ...10 D3) Fragrance ......A small amount is sufficient, so this For example, #solution with a concentration of about 5,000 to 20,000 times was used as the reagent of this example.

This Example 1 was used as a cleaning water tank (normally 111 σ
) The above color change indicator is present in the amount previously described.
Insert as much as possible. In practice, a simple device is provided in the tank (2;-) that utilizes the up and down movement of the liquid level in the tank or the operation of a lever, and injects a fixed amount of reagent into the tank each time the liquid level moves up and down.

In this way, when the toilet is used normally and the test urine is injected into the toilet, the color of the wash water reservoir in the toilet changes from yellow to blue if it contains pathological protein. Change color. If the color change indicator in the reagent is mixed into the washing liquid at the above concentration, the presence or absence of a reaction can be determined approximately 10 seconds after injection of test urine.

Example 2 When conducting a shield test in urine 1) Color change indicator An indicator system that reacts with sugar, which is a type of pathological component in urine, is as follows: 1) Grape #i oxidase...・・・・・・
・1.5 Wll) Hydrogen peroxide degrading enzyme
・・・・・・・・・ 1.5 Da11θ ortho-tolidine ・・・・・・・・・ 1.51Iv2
) Detergent nonionic surfactant (neutral) 20 q
3) Fragrance: Since a small amount is sufficient, this is made into a solution with a concentration of, for example, 5,000 to 20,000 times, and used as the reagent for this example, and the same method as in Example 1 is used. The presence or absence of sugar in the test urine is measured by the color of the urine 10 seconds after injection.

As the above-mentioned chromogen, ortho, tolidine [Hoechst product] is shown, but iodine CZI-) (Ames product) product - amino-6-chloro-9-dimethylaminopropylcarbazole hydrochloride (BM test), 2. Even if you use other commercially available products such as diaminofluorene dihydrochloride,
There is nothing different about this aspect.

In addition, both the color change indicators of Example 1 and Example 2 are contained, and at least -1 of urine protein and urine sugar is contained.
There is no difference in this invention even if the urine changes color when a pathological component is contained in the urine to be tested.

In the above-mentioned example, a screening test for urine protein and urine sugar was shown as an example, but Veroxida and its reagent are also included within the scope of the present invention, and the indicator itself, in other words, one that changes color due to pathological components. If so, it is not limited to the above example.

Further, in the above example, the reagent was illustrated as a liquid, but there is no difference whether the reagent is in the form of tablets, granules, or powder. In this case, even if sodium sulfate, sodium carbonate, etc. are added as an extender, there will be no change in the present invention.

In addition, the type of detergent is not particularly limited as long as it is neutral and does not adversely affect the discoloration reaction, and the amount of detergent may be increased or decreased depending on the cleaning ability without any change in this invention. do not have.

Claims (1)

[Scope of Claims] 1) A water-soluble urine screening reagent for use in toilet flushing water, which contains a detergent and a color change indicator that changes color upon reaction with at least one of the pathological components in excreted urine. 2) Urine screening for toilet flush water injection according to claim 1, wherein the pathological component in excreted urine is one of urine protein, urine sugar, pH, and urine occult blood. reagent. 3) A water-soluble urine screening reagent consisting of a solid or liquid containing a color change indicator and a detergent that changes color when it reacts with at least one of the pathological components of excreted urine is placed in the water basin of the flush toilet or the toilet flush water tank. A urine screening test method characterized in that a sufficient amount of post-excreted urine is injected into the toilet bowl, and the pathological components in the excreted urine are reacted with the urine screening reagent in the toilet bowl.