JPH09510467A - 興奮毒性に関連した神経病理学的な状態において神経保護作用を行う薬剤の製造におけるアミノアルコールのｎ−アシル誘導体の使用 - Google Patents

興奮毒性に関連した神経病理学的な状態において神経保護作用を行う薬剤の製造におけるアミノアルコールのｎ−アシル誘導体の使用

Info

Publication number
JPH09510467A
JPH09510467A JP7524371A JP52437195A JPH09510467A JP H09510467 A JPH09510467 A JP H09510467A JP 7524371 A JP7524371 A JP 7524371A JP 52437195 A JP52437195 A JP 52437195A JP H09510467 A JPH09510467 A JP H09510467A
Authority
JP
Japan
Prior art keywords
acid
group
use according
aromatic
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7524371A
Other languages
English (en)
Japanese (ja)
Inventor
ヴァッレ，フランチェスコ デッラ
レオン，アルベルタ
ロレンツィ，シルヴァーナ
Original Assignee
ライフグループ エス．ピー．エイ．
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ライフグループ エス．ピー．エイ． filed Critical ライフグループ エス．ピー．エイ．
Publication of JPH09510467A publication Critical patent/JPH09510467A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
JP7524371A 1994-03-21 1995-03-17 興奮毒性に関連した神経病理学的な状態において神経保護作用を行う薬剤の製造におけるアミノアルコールのｎ−アシル誘導体の使用 Pending JPH09510467A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI940523A IT1271623B (it) 1994-03-21 1994-03-21 N-acilderivati di aminoalcoli con acidi monocarbossilici e bicarbossilici con attivita' neuroprotettiva nelle patologie neurologiche correlate ad eccitotossicita'
IT94A000523 1994-03-21
PCT/EP1995/001002 WO1995025509A2 (en) 1994-03-21 1995-03-17 Use of n-acyl derivatives of aminoalcohols in the manufacture of a medicament for practising neuroprotective action in neuropathological states connected with excitotoxicity

Publications (1)

Publication Number Publication Date
JPH09510467A true JPH09510467A (ja) 1997-10-21

Family

ID=11368280

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7524371A Pending JPH09510467A (ja) 1994-03-21 1995-03-17 興奮毒性に関連した神経病理学的な状態において神経保護作用を行う薬剤の製造におけるアミノアルコールのｎ−アシル誘導体の使用

Country Status (8)

Country Link
US (1) US5925678A (und)
EP (1) EP0804179B1 (und)
JP (1) JPH09510467A (und)
AT (1) ATE182075T1 (und)
AU (1) AU2109095A (und)
DE (1) DE69510825D1 (und)
IT (1) IT1271623B (und)
WO (1) WO1995025509A2 (und)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019532069A (ja) * 2016-10-13 2019-11-07 カーノット， エルエルシー Ｎ−アシルエタノールアミド誘導体およびその使用

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1271266B (it) * 1994-12-14 1997-05-27 Valle Francesco Della Impiego terapeutico di ammidi di acidi mono e bicarbossilici con amminoalcoli,selettivamente attive sul recettore periferico dei cannabinoidi
US6410597B1 (en) * 2000-02-25 2002-06-25 Virginia Commonwealth University Hydroxyalkyl amide analogs of ceramide
US20030191064A1 (en) * 2001-01-23 2003-10-09 Kopke Richard D. Methods for preventing and treating loss of balance function due to oxidative stress
CN1523994A (zh) * 2001-05-23 2004-08-25 钱吉子 一种用于预防和/或治疗痴呆的以灵芝提取物、十八碳烯酰胺及其衍生物作为有效成分的组合物
ITMI20011483A1 (it) * 2001-07-11 2003-01-11 Res & Innovation Soc Coop A R Uso di composti come antagonisti funzionali ai recettori centrali deicannabinoidi
DE10351111A1 (de) * 2003-11-03 2005-06-16 Langlotz, Rainer Arzneimittel und Verfahren zu ihrer Herstellung

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6183147A (ja) * 1984-09-28 1986-04-26 Nippon Chemiphar Co Ltd 新規なアミノアルコール誘導体およびその製造法並びにそれを有効成分とするグルタミン酸遮断剤
US5227397A (en) * 1989-04-28 1993-07-13 Pfizer Inc. Polyamines and polypeptides useful as antagonists of excitatory amino acid neuro-transmitters and/or as blockers of calcium channels
US5618842A (en) * 1991-12-31 1997-04-08 Lifegroup S.P.A. N-acyl derivatives of aminoalcohols with polycarboxylic acids able to modulate mast cells in inflammatory processes having neuroimmunogenic origin
IT1252866B (it) * 1991-12-31 1995-06-28 Lifegroup Spa N-acilderivati di aminoalcooli con acidi policarbossilici atti alla modulazione dei mastociti nei processi infiammatori su base neuroimmunogenica
IT1257697B (it) * 1992-04-24 1996-02-01 Lifegroup Spa N-acil derivati di aminoalcooli come agenti terapeutici attivi sull'edema neurogenico endoneurale a livello del nervo periferico.
WO1993025203A1 (en) * 1992-06-17 1993-12-23 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Method of treating and protecting against central nervous system ischemia, hypoxia, degeneration, and trauma with a 5-aminocarbonyl-sh-dibenzo[a,d]cyclohepten-5,10-imine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019532069A (ja) * 2016-10-13 2019-11-07 カーノット， エルエルシー Ｎ−アシルエタノールアミド誘導体およびその使用

Also Published As

Publication number Publication date
EP0804179B1 (en) 1999-07-14
ATE182075T1 (de) 1999-07-15
EP0804179A2 (en) 1997-11-05
DE69510825D1 (de) 1999-08-19
ITMI940523A1 (it) 1995-09-21
US5925678A (en) 1999-07-20
WO1995025509A2 (en) 1995-09-28
WO1995025509A3 (en) 1995-10-12
ITMI940523A0 (it) 1994-03-21
IT1271623B (it) 1997-06-04
AU2109095A (en) 1995-10-09

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