JPH09509428A - 薬理学的に活性な薬剤の血清半減期を増加させるための方法および組成物 - Google Patents
薬理学的に活性な薬剤の血清半減期を増加させるための方法および組成物Info
- Publication number
- JPH09509428A JPH09509428A JP7522373A JP52237395A JPH09509428A JP H09509428 A JPH09509428 A JP H09509428A JP 7522373 A JP7522373 A JP 7522373A JP 52237395 A JP52237395 A JP 52237395A JP H09509428 A JPH09509428 A JP H09509428A
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- transthyretin
- ligand
- composition according
- pharmacologically active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20038794A | 1994-02-23 | 1994-02-23 | |
US08/200,387 | 1994-02-23 | ||
PCT/US1995/001815 WO1995022992A2 (en) | 1994-02-23 | 1995-02-13 | Method and compositions for increasing the serum half-life of pharmacologically active agents |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH09509428A true JPH09509428A (ja) | 1997-09-22 |
Family
ID=22741505
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7522373A Pending JPH09509428A (ja) | 1994-02-23 | 1995-02-13 | 薬理学的に活性な薬剤の血清半減期を増加させるための方法および組成物 |
Country Status (7)
Country | Link |
---|---|
US (1) | US5714142A (es) |
EP (1) | EP0802798A1 (es) |
JP (1) | JPH09509428A (es) |
AU (1) | AU1843295A (es) |
CA (1) | CA2184002A1 (es) |
MX (1) | MX9603570A (es) |
WO (1) | WO1995022992A2 (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005529108A (ja) * | 2002-04-04 | 2005-09-29 | アムジエン・インコーポレーテツド | 薬理学的活性ペプチド/タンパク質の血清中半減期を上昇させるためのトランスサイレチンペプチド/タンパク質融合物の使用 |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU5727798A (en) * | 1996-12-23 | 1998-07-17 | Texas A & M University, The | Anti-amyloidogenic agents |
US6506798B1 (en) | 1997-07-01 | 2003-01-14 | Warner-Lambert Company | 4-Arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective MEK inhibitors |
GB9824632D0 (en) * | 1998-11-10 | 1999-01-06 | Celltech Therapeutics Ltd | Biological compounds |
CA2370653A1 (en) * | 1999-04-26 | 2000-11-02 | Albert Burger | Pharmaceutical compositions of tetrac and methods of use thereof |
US6740680B1 (en) * | 1999-04-26 | 2004-05-25 | Becton Pharma, Inc. | Pharmaceutical compositions to tetrac and methods of use thereof |
US6656730B1 (en) * | 1999-06-15 | 2003-12-02 | Isis Pharmaceuticals, Inc. | Oligonucleotides conjugated to protein-binding drugs |
US6887842B1 (en) * | 1999-11-19 | 2005-05-03 | The Board Of Trustees Of The Leland Stanford Junior University | Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug |
EP1339702A1 (en) | 2000-03-15 | 2003-09-03 | Warner-Lambert Company | 5-amide substituted diarylamines as mek inhibitors |
FI107018B (fi) * | 2000-04-06 | 2001-05-31 | Ipsat Therapies Oy | Dermatologinen käyttö ja valmiste |
EP1399484B1 (en) * | 2001-06-28 | 2010-08-11 | Domantis Limited | Dual-specific ligand and its use |
US6924376B2 (en) | 2002-04-17 | 2005-08-02 | Cytokinetics, Inc. | Compounds, compositions and methods |
US6949538B2 (en) * | 2002-07-17 | 2005-09-27 | Cytokinetics, Inc. | Compounds, compositions, and methods |
JP2005539062A (ja) * | 2002-09-13 | 2005-12-22 | サイトキネティクス・インコーポレーテッド | 化合物、組成物および方法 |
WO2005042697A2 (en) * | 2003-10-06 | 2005-05-12 | Cytokinetics, Inc. | Compounds, compositions and methods |
US7833979B2 (en) * | 2005-04-22 | 2010-11-16 | Amgen Inc. | Toxin peptide therapeutic agents |
EP1912946B1 (en) * | 2005-07-20 | 2009-05-27 | Eli Lilly And Company | Pyridine derivatives as dipeptedyl peptidase inhibitors |
WO2007015807A1 (en) * | 2005-07-20 | 2007-02-08 | Eli Lilly And Company | Phenyl compounds |
US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
US8168592B2 (en) * | 2005-10-21 | 2012-05-01 | Amgen Inc. | CGRP peptide antagonists and conjugates |
CA2667678A1 (en) * | 2006-10-25 | 2008-07-24 | Amgen Inc. | Toxin peptide therapeutic agents |
EP2162540A2 (en) | 2007-05-22 | 2010-03-17 | Amgen Inc. | Compositions and methods for producing bioactive fusion proteins |
CN102015606B (zh) | 2007-06-08 | 2015-02-04 | 满康德股份有限公司 | IRE-1α抑制剂 |
US20090131380A1 (en) * | 2007-11-16 | 2009-05-21 | Pekka Heino | Novel pharmaceutical composition for topical treatment of skin psoriasis and the treatment method thereof |
MX347291B (es) | 2009-03-20 | 2017-04-17 | Amgen Inc | Inmunoglobulinas portadoras y usos de las mismas. |
EA201370076A1 (ru) | 2010-09-22 | 2013-08-30 | Амген Инк. | Иммуноглобулины-переносчики и их применение |
CA2828405A1 (en) | 2011-02-28 | 2012-09-07 | Istituto Di Ricovero E Cura A Carattere Scientifico Materno-Infantile Bu Rlo Garofolo - Ospedale Di Alta Specializzazione E Di Rilievo Nazionale | Apoptosis-inducing molecules and uses therefor |
US9340590B2 (en) | 2011-03-16 | 2016-05-17 | Amgen Inc. | Potent and selective inhibitors of NaV1.3 and NaV1.7 |
CA3062003C (en) | 2012-05-17 | 2022-01-11 | Extend Biosciences, Inc. | Vitamin d as a targeting group for therapeutic peptides |
EP2908849B1 (en) * | 2012-08-31 | 2019-04-17 | Board Of Regents, The University Of Texas System | A method to improve pharmacokinetics of drugs |
US9029342B2 (en) | 2012-09-17 | 2015-05-12 | Board Of Regents Of The University Of Texas System | Compositions of matter that reduce pain, shock, and inflammation by blocking linoleic acid metabolites and uses thereof |
WO2014099984A1 (en) | 2012-12-20 | 2014-06-26 | Amgen Inc. | Apj receptor agonists and uses thereof |
WO2014165277A2 (en) | 2013-03-12 | 2014-10-09 | Amgen Inc. | POTENT AND SELECTIVE INHIBITORS OF Nav1.7 |
CA2951391C (en) | 2014-06-10 | 2021-11-02 | Amgen Inc. | Apelin polypeptides |
EP3179857B1 (en) | 2014-08-14 | 2021-09-08 | Mamoun M. Alhamadsheh | Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life |
US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
EP3220961B1 (en) | 2014-10-22 | 2023-07-05 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
US9616109B2 (en) | 2014-10-22 | 2017-04-11 | Extend Biosciences, Inc. | Insulin vitamin D conjugates |
US20190382462A1 (en) | 2017-01-13 | 2019-12-19 | Pietro P. Sanna | Methods and compositions for treating hpa hyperactivity |
US20210346513A1 (en) | 2017-08-04 | 2021-11-11 | Amgen Inc. | Method of conjugation of cys-mabs |
FR3113904B1 (fr) | 2020-09-08 | 2022-08-12 | Innoverda | Procédé de synthèse du 3,5-diiodo-4-hydroxy benzylalcool |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4410633A (en) * | 1980-09-25 | 1983-10-18 | Corning Glass Works | Method for the measurement of free thyroxine or 3,5,3'-triiodothyronine in a liquid sample |
US5068227A (en) * | 1989-01-18 | 1991-11-26 | Cyclex, Inc. | Cyclodextrins as carriers |
SE509359C2 (sv) * | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
US5273885A (en) * | 1992-07-31 | 1993-12-28 | Syntex (U.S.A.) Inc. | Conjugates of monophenyl thyroid analogs useful in assays |
-
1995
- 1995-02-13 CA CA002184002A patent/CA2184002A1/en not_active Abandoned
- 1995-02-13 AU AU18432/95A patent/AU1843295A/en not_active Abandoned
- 1995-02-13 EP EP95910249A patent/EP0802798A1/en not_active Withdrawn
- 1995-02-13 JP JP7522373A patent/JPH09509428A/ja active Pending
- 1995-02-13 MX MX9603570A patent/MX9603570A/es unknown
- 1995-02-13 WO PCT/US1995/001815 patent/WO1995022992A2/en not_active Application Discontinuation
-
1996
- 1996-06-13 US US08/664,372 patent/US5714142A/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005529108A (ja) * | 2002-04-04 | 2005-09-29 | アムジエン・インコーポレーテツド | 薬理学的活性ペプチド/タンパク質の血清中半減期を上昇させるためのトランスサイレチンペプチド/タンパク質融合物の使用 |
Also Published As
Publication number | Publication date |
---|---|
MX9603570A (es) | 1997-03-29 |
EP0802798A1 (en) | 1997-10-29 |
CA2184002A1 (en) | 1995-08-31 |
US5714142A (en) | 1998-02-03 |
WO1995022992A2 (en) | 1995-08-31 |
WO1995022992A8 (en) | 2002-02-14 |
AU1843295A (en) | 1995-09-11 |
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