JPH09509046A - トランスジェニックマウス - Google Patents
トランスジェニックマウスInfo
- Publication number
- JPH09509046A JPH09509046A JP7515252A JP51525294A JPH09509046A JP H09509046 A JPH09509046 A JP H09509046A JP 7515252 A JP7515252 A JP 7515252A JP 51525294 A JP51525294 A JP 51525294A JP H09509046 A JPH09509046 A JP H09509046A
- Authority
- JP
- Japan
- Prior art keywords
- yac
- mutation
- mouse
- human
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000011830 transgenic mouse model Methods 0.000 title claims abstract description 17
- 238000000034 method Methods 0.000 claims abstract description 66
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 53
- 241000699666 Mus <mouse, genus> Species 0.000 claims abstract description 30
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 22
- 210000000130 stem cell Anatomy 0.000 claims abstract description 18
- 230000009261 transgenic effect Effects 0.000 claims abstract description 13
- 210000001671 embryonic stem cell Anatomy 0.000 claims abstract description 11
- 241000699660 Mus musculus Species 0.000 claims abstract description 10
- 230000006801 homologous recombination Effects 0.000 claims abstract description 8
- 238000002744 homologous recombination Methods 0.000 claims abstract description 8
- 210000002459 blastocyst Anatomy 0.000 claims abstract description 7
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- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical group C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims description 34
- 101710137189 Amyloid-beta A4 protein Proteins 0.000 claims description 28
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- 229960000723 ampicillin Drugs 0.000 description 2
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 2
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- OPCHFPHZPIURNA-MFERNQICSA-N (2s)-2,5-bis(3-aminopropylamino)-n-[2-(dioctadecylamino)acetyl]pentanamide Chemical compound CCCCCCCCCCCCCCCCCCN(CC(=O)NC(=O)[C@H](CCCNCCCN)NCCCN)CCCCCCCCCCCCCCCCCC OPCHFPHZPIURNA-MFERNQICSA-N 0.000 description 1
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- MJNIWUJSIGSWKK-UHFFFAOYSA-N Riboflavine 2',3',4',5'-tetrabutanoate Chemical compound CCCC(=O)OCC(OC(=O)CCC)C(OC(=O)CCC)C(OC(=O)CCC)CN1C2=CC(C)=C(C)C=C2N=C2C1=NC(=O)NC2=O MJNIWUJSIGSWKK-UHFFFAOYSA-N 0.000 description 1
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- BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Environmental Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Microbiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15908493A | 1993-11-29 | 1993-11-29 | |
| US08/159,084 | 1993-11-29 | ||
| PCT/US1994/013604 WO1995014769A1 (fr) | 1993-11-29 | 1994-11-22 | Souris transgenique preparee a l'aide de chromosomes artificiels de levure et d'une recombinaison homologue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH09509046A true JPH09509046A (ja) | 1997-09-16 |
Family
ID=22571017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7515252A Pending JPH09509046A (ja) | 1993-11-29 | 1994-11-22 | トランスジェニックマウス |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPH09509046A (fr) |
| WO (1) | WO1995014769A1 (fr) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004076661A1 (fr) * | 2003-02-27 | 2004-09-10 | Renascience Co., Ltd. | Production de cellules nerveuses pathologiques utilisant en combinaison un procede tres efficace d'induction de differenciation de nerf et des cellules souches embryonnaires knockin a mutation pathologique |
| JP2007252217A (ja) * | 2006-03-20 | 2007-10-04 | Tottori Univ | 遺伝子導入非ヒト動物 |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2042093C (fr) * | 1990-05-09 | 2002-12-24 | Gyula Hadlaczky | Lignee de cellules renfermant un exces de centromeres mammaliens |
| DE69233109T2 (de) * | 1992-01-07 | 2004-05-19 | Elan Pharmaceuticals, Inc., San Francisco | Transgene tiermodelle fur alzheimer-krankheit |
| EP0832205A1 (fr) * | 1995-06-07 | 1998-04-01 | Athena Neurosciences, Inc. | Procede d'identification de therapies de la maladie d'alzheimer a l'aide de modeles animaux transgeniques |
| US6717031B2 (en) | 1995-06-07 | 2004-04-06 | Kate Dora Games | Method for selecting a transgenic mouse model of alzheimer's disease |
| CA2222174A1 (fr) * | 1995-06-07 | 1996-12-19 | Athena Neurosciences, Inc. | Procede pour identifier une therapeutique de la maladie d'alzheimer a l'aide de modeles animaux transgeniques |
| DE19530107A1 (de) * | 1995-08-16 | 1997-02-20 | Deutsches Krebsforsch | Verfahren zur gezielten Veränderung von Zell-DNA |
| US6025155A (en) * | 1996-04-10 | 2000-02-15 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| US6077697A (en) | 1996-04-10 | 2000-06-20 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| WO1999009150A1 (fr) * | 1996-08-15 | 1999-02-25 | Bayer Corporation | Methode permettant d'introduire des modifications dans un gene |
| AU4258097A (en) | 1996-09-06 | 1998-03-26 | Duke University | Methods for testing compounds for use as therapeutic antioxidants |
| EP0912722A4 (fr) * | 1997-02-21 | 2001-12-05 | Michael Nehls | Procede servant a construire des vecteurs de recombinaison homologue pour une mutagenese dirigee |
| US6090554A (en) * | 1997-10-31 | 2000-07-18 | Amgen, Inc. | Efficient construction of gene targeting vectors |
| US6335185B1 (en) | 1998-02-03 | 2002-01-01 | University Technologies International Inc. | Bacteriophage vectors generated by bacteriophage/plasmid recombination |
| US6503712B1 (en) | 2000-05-10 | 2003-01-07 | Amgen Inc. | Methods and compositions for preparing a genomic library for knockout targeting vectors |
| WO2002044350A2 (fr) | 2000-11-28 | 2002-06-06 | Henkel Kommanditgesellschaft Auf Aktien | Nouvelle cyclodextrine-glucanotransferase (cgtase) issue de bacillus agaradherens (dsm 9948) et produits detergents et de nettoyage comprenant cette nouvelle cyclodextrine-glucanotransferase |
| EP2527456B1 (fr) | 2004-10-22 | 2018-05-16 | Revivicor Inc. | Porcs transgéniques déficients en chaîne légère d'immunoglobuline endogène |
| ES2316209B1 (es) * | 2005-12-02 | 2009-11-13 | Universidad Autonoma De Madrid | Modelo animal de enfermedad de alzheimer, procedimiento de obtencion y sus aplicaciones. |
| EP2348827B1 (fr) | 2008-10-27 | 2015-07-01 | Revivicor, Inc. | Ongulés immunodéprimés |
-
1994
- 1994-11-22 JP JP7515252A patent/JPH09509046A/ja active Pending
- 1994-11-22 WO PCT/US1994/013604 patent/WO1995014769A1/fr active Application Filing
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004076661A1 (fr) * | 2003-02-27 | 2004-09-10 | Renascience Co., Ltd. | Production de cellules nerveuses pathologiques utilisant en combinaison un procede tres efficace d'induction de differenciation de nerf et des cellules souches embryonnaires knockin a mutation pathologique |
| JP2007252217A (ja) * | 2006-03-20 | 2007-10-04 | Tottori Univ | 遺伝子導入非ヒト動物 |
| JP4590638B2 (ja) * | 2006-03-20 | 2010-12-01 | 国立大学法人鳥取大学 | 家族性筋萎縮性側索硬化症（ｆａｌｓ）発症するトランスジェニックマウス |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995014769A1 (fr) | 1995-06-01 |
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