JPH09255557A - Gel-like emulsified composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a gel-like emulsified composition suitable for cosmetics or medicines which are excellent in feeling when used and reduced in surfactant formulation without impairing usability. SOLUTION: This gel-like emulsified composition contains 0.1-5wt.% of an active ingredient, i.e., a polysaccharide produced by microorganisms such as Pseudomonas aerodia, composed of glucose, glucuronic acid and rhamnose as constituent saccharides, with recurring unit of the formula [→3)-β-D-glucose(1→4)-β-D-glucuronic acid(1→4)-β-D-glucose(1→4)-α-L-rhamnose(1→] ((n) is an integer). This composition is prepared into a basic cosmetic, makeup cosmetic, hair cosmetic, systemic cosmetic or skin preparation for external use by formulating the above active ingredient with, optionally, a base ingredient composed of oily phase and aqueous phase components, surfactant, etc. In this composition, by reducing surfactant formulation, messy makeup and safety spoilage due to surfactant can be avoided in the case of cosmetics, and intradermal reservability loss, safety spoilage, etc., can be avoided in the case of skin preparation for external use without deteriorating the usability of this composition.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an emulsified composition, and more particularly to an emulsified composition containing a reduced amount of a surfactant and suitable for cosmetics or pharmaceuticals.

[0002]

BACKGROUND OF THE INVENTION In cosmetics and external medicines for skin, surfactants are used to emulsify or solubilize water and oily ingredients,
It was an indispensable component that was blended in order to stably disperse the powder component in the base material and in the makeup remover to dissolve, disperse, and remove stains. On the other hand, however, the surfactant cannot be said to be a preferable component in terms of safety when incorporated into the above cosmetics or skin external medicine. This is because the surface-active effect of the surface-active agent acts usefully as described above, and at the same time, irritation is easily exerted on the skin. In addition, the surfactant is
Because it has both lipophilic and hydrophilic properties,
It is said that it does not affect the makeup retention of makeup cosmetics very well. Further, makeup removers such as cleansing agents sometimes cause redness due to a synergistic effect of irritation caused by a surfactant remaining on the skin without being wiped off and irritation caused by friction during wiping.

Reflecting such a situation, various methods have been attempted so far for the purpose of reducing the amount of the surfactant compounded in the cosmetics and the skin external medicine. As an example of the method, a high internal phase W / O in which a large amount of an aqueous phase is encapsulated in an oily gel composed of bentonite-water gel in which an oily component is uniformly dispersed or sugar-polyglycerin ester-hydrocarbon
Examples thereof include emulsification with a self-emulsifying thickener such as an emulsion and a long-chain alkyl acrylate polymer.

These methods have made it possible to emulsify without using a surfactant or to significantly reduce the amount of the compounded surfactant, but for the bentonite type, gelation does not stop and the emulsion solidifies within a few years. There is a problem that the degree of freedom of prescription components is low for high internal phase W / O emulsions. Also, emulsification with self-emulsifying thickeners causes the powder to aggregate due to the effect of the thickeners. There is a problem that it is difficult to use in a foundation system because it is easy to do.

Further, in the emulsification using an organic polymer gelling agent, a technique has been known in which an agar component or gelatin is used to disperse an oily component therein to emulsify. However, an emulsion using agar or gelatin is known. Then, although a moist or moisturizing or pleasant refreshing feeling is obtained, there is a tattering feeling when picked up by the hand and there is a problem in usability. Therefore, there has been a demand for a method of reducing the compounding amount of a surfactant in an emulsified composition used in cosmetics, external medicines for skin and the like, while maintaining the emulsifier form, without impairing usability.

On the other hand, with regard to polysaccharides composed of glucose, glucuronic acid and rhamnose represented by the following general formula (I) which can be produced by microorganisms such as Pseudomonas erodia, foods etc. can be used as gelling agents. However, there is no report that an emulsified composition having no problem in usability and emulsifying property was obtained by using it in an emulsified composition.

[0007]

SUMMARY OF THE INVENTION The present invention has been made from the above point of view, and provides cosmetics, external medicines for skin, etc., which are excellent in feeling of use and have a reduced amount of surfactant incorporated without impairing usability. An object is to provide an emulsified composition.

[0008]

Means for Solving the Problems As a result of intensive studies to solve the above problems, the present inventors prefer to add a specific polysaccharide produced by Pseudomonas erodia to an emulsion composition. The inventors have found that a feeling of use can be obtained and that the amount of the surfactant blended can be reduced without impairing the usability while maintaining the emulsifier form, and completed the present invention.

That is, the present invention is an emulsion composition containing glucose, glucuronic acid, and a polysaccharide having rhamnose as a constituent sugar produced by Pseudomonas erodia. Here, the polysaccharide produced by Pseudomonas erodia used in the present invention means a polysaccharide that can be produced by Pseudomonas erodia. That is, the polysaccharide used in the present invention is not limited to the polysaccharide produced by Pseudomonas erodia, and a polysaccharide similar to the polysaccharide produced by a microorganism other than Pseudomonas erodia is also used in the present invention. It is possible.

The polysaccharide contained in the emulsion composition of the present invention is specifically represented by the following general formula (I) [→
3) -β-D-glucose (1 → 4) -β-D-glucuronic acid (1 → 4) -β-D-glucose (1 → 4) -α-L
There may be mentioned polysaccharides having rhamnose (1 →) as a repeating unit.

[0011]

Embedded image

(However, n represents an integer.) In the polysaccharide represented by the above general formula (I) used in the present invention, n in the formula represents an integer, and the number of n in the polysaccharide which is preferable in the present invention. Is 2 to 4000, and 10 to 10
It is more preferably 00, further preferably 20
~ 500.

The content of the above-mentioned polysaccharide in the emulsion composition of the present invention is 0.1 to 5% by weight based on the total amount of the composition.
It is preferred that The emulsified composition of the present invention contains a base component (consisting of an oil phase component and an aqueous phase component) contained in a usual emulsified composition together with the above-mentioned polysaccharide, and further contains a surfactant, various uses, purposes and the like. Optionally containing various components appropriately selected. The emulsified composition of the present invention can be produced in the same manner as a usual emulsified composition except that the above-mentioned polysaccharide is added to the aqueous phase component.

Specific examples of the emulsified composition of the present invention include cosmetics and skin external medicines. The emulsified composition of the present invention contains glucose produced by Pseudomonas erodia as described above, a polysaccharide having glucuronic acid and rhamnose as a constituent sugar, and by containing such a polysaccharide, The composition can be imparted with a moist or moist or refreshing desired feeling of use, and further, the content of the surfactant in the composition can be reduced without impairing usability. That is, in an emulsified composition in which a surfactant is reduced by using a conventional organic polymer gelling agent, it is possible to improve the tattered feeling that has been a problem while maintaining a preferable usability of the emulsified composition. it can. In addition, the emulsified composition of the present invention does not hinder the emulsifier form by containing these components.

If it is possible to reduce the amount of the surfactant incorporated in the emulsion composition as described above, cosmetics may suffer from problems such as cosmetic disintegration and reduced safety due to the surfactant. In addition, it becomes possible to effectively solve problems such as a loss of skin retention and a decrease in safety due to a surfactant in a skin external medicine without reducing the usability of the emulsified composition. .

[0016]

Embodiments of the present invention will be described below. (1) Emulsified composition of the present invention The emulsified composition of the present invention is characterized by containing a polysaccharide produced by Pseudomonas erodia, which comprises glucose, glucuronic acid and rhamnose as constituent sugars.

The polysaccharide having glucose, glucuronic acid and rhamnose as a constituent sugar produced by Pseudomonas erodia used in the present invention is as described above.
In order to obtain such a polysaccharide used in the present invention, for example, a microorganism having the ability to produce the above-mentioned polysaccharide may be cultured and the desired polysaccharide may be separated and purified from the culture. More specifically, Pseudomonas erodia etc. is inoculated into a general fermentation stock solution to carry out ordinary fermentation, and the above-mentioned polysaccharide is separated and purified from the obtained fermentation product by a usual method such as centrifugation or chromatography. The above-mentioned polysaccharide can be produced. In the present invention, it is also possible to use a culture containing the above-mentioned polysaccharide or a crude product in the process of purification. Since many of the above-mentioned polysaccharides are commercially available as products, these can be used in the present invention. For example, gellan gum, which is a fermentation product of Pseudomonas erodia, is commercially available from Merck & Co., Inc. under the trade name of Kelcogel as a polysaccharide represented by the general formula (I) preferably used in the present invention.

The preferred content of the above-mentioned polysaccharide in the emulsion composition of the present invention is 0.1 to 5% by weight, and 0.5 to 4
The content is more preferably the content by weight, and further preferably the content is 1 to 3% by weight.

The emulsion composition of the present invention contains, in addition to the above-mentioned polysaccharide, the base components (water phase component and oil phase component) contained in a usual emulsion composition, and further contains a surfactant and various uses,
Various components that are appropriately selected according to the purpose and the like are arbitrarily contained within the range not impairing the effects of the present invention.

The base component in the emulsified composition of the present invention comprises an aqueous phase component and an oil phase component in the same manner as the base component of a conventional emulsified composition. It is preferable that the oil agent constituting the oil agent is a liquid oil agent at normal temperature and pressure. The preferable content of these oil agents is 1 to 90% by weight, and 5 to 80% by weight based on the total amount of the composition.
Content of 10 to 70% by weight is more preferable.
Is more preferable. The substance constituting the aqueous phase component of the base is preferably water, and the preferable content is 5 to 80% by weight based on the total amount of the composition,
More preferably, the content is 10 to 70% by weight,
It is more preferable that the content is 20 to 60% by weight.

Various components other than the above-mentioned polysaccharides contained in the emulsion composition of the present invention, including the base component, vary depending on the use, purpose, etc. of the emulsion composition of the present invention, and a detailed description thereof will be given. Will be performed for each composition of the cosmetics and the skin external preparations described below. Further, the blending of the surfactant in the emulsion composition of the present invention is optional as described above, and in the present invention, the content of the surfactant is smaller than that of a usual emulsion composition by containing the polysaccharide. A good emulsion can be obtained. Further, in the present invention, it is possible to prepare an emulsion composition containing no surfactant, if necessary.

Such an emulsified composition of the present invention is similar to a conventional emulsified composition except that the above-mentioned polysaccharide is added to the water phase component. It can be manufactured by a method of heating the phase components to about 70 to 90 ° C., mixing and stirring and emulsifying them, and then cooling.

Specific examples of such an emulsified composition of the present invention include cosmetics and skin external medicines. The embodiments will be described below in the order of the cosmetic of the present invention and the external skin drug.

(2) Cosmetic of the present invention The cosmetic to which the emulsion composition of the present invention can be applied is not particularly limited as long as it is a cosmetic to which an emulsion type dosage form can be applied. For example, cream Examples thereof include basic cosmetics such as, makeup cosmetics such as foundations, hair cosmetics such as hair creams, and whole-body cosmetics such as body creams.

As described above, in the cosmetic of the present invention,
A good emulsion can be obtained by adding a surfactant in an amount smaller than usual or without adding a surfactant, which results in a cosmetic derived from a surfactant which has been a problem in conventional emulsified cosmetics. It is possible to solve a collapse and a decrease in safety. Thus, the cosmetic of the present invention has a long-lasting makeup,
Although it is excellent in safety, the cosmetic of the present invention has a refreshing feeling of use, and when it is taken by the hand, which has been a problem with an emulsion composition using a conventional organic polymer gelling agent. The tattered feeling is also improved and the usability is improved.

The cosmetic of the present invention comprises the above-mentioned polysaccharide and
It can be produced according to the usual method for producing cosmetics using various other components listed below. In the cosmetic of the present invention, as components to be blended other than the above-mentioned polysaccharides,
Water usually added to cosmetics; vaseline, squalane,
Hydrocarbons such as microcrystalline wax, esters such as jojoba oil, gallow, carnauba wax; triglycerides such as olive oil and tallow; cetanol,
Higher alcohols such as oleyl alcohol and stearyl alcohol; higher fatty acids such as stearic acid and oleic acid; polyhydric alcohols such as glycerin, propylene glycol and 1,3-butanediol; lower alcohols such as ethanol and propanol; dimethyl Silicone such as polysiloxane and dimethylpolysiloxane cyclic tetramer; nonionic surfactant such as fatty acid monoglyceride and pooxyethylene hydrogenated castor oil; anionic surfactant such as sodium lauryl sulfate and alkylsulfosuccinate; quaternary alkylamine salt Cationic surfactants such as; amphoteric surfactants such as alkyl betaines; thickeners such as gum arabic and carboxyvinyl polymers; parabens
Preservatives such as chlorhexidine gluconate; powders such as talc, silica gel and titanium oxide; antioxidants such as tocopherol and butylhydroxytoluene; UV absorbers such as para-aminobenzoic acid derivatives and benzophenone derivatives; polyethylene glycol, hyaluronic acid, etc. Moisturizers; anti-inflammatory agents such as dipotassium glycyrrhizinate; pH adjusting agents such as citrate and acetate; chelating agents; fragrances; pigments; placenta extracts, ginseng extracts, sterol glycosides, etc. according to various purposes Examples include medicinal properties.

(3) External skin drug of the present invention The external skin drug to which the emulsion composition of the present invention can be applied is not particularly limited as long as it is an external skin drug to which an emulsion type dosage form can be applied. In the skin external preparation of the present invention, a good emulsion can be obtained by adding a surfactant in a smaller amount than usual or without adding a surfactant, but this causes a problem in conventional emulsification type skin external preparations. It is possible to solve the problems such as the loss of storability in the skin and the decrease in safety due to the said surfactants. Also,
If the system does not contain a surfactant, it can be suitably applied to a matrix such as a patch, which is very important in safety under application of a plug. Further, similar to the above cosmetics, the usability and the like have been improved.

The skin external medicine of the present invention includes, for example, antipruritic agents containing antihistamines, steroid hormones and the like, antipyretic agents containing bactericides and antibiotics,
An anti-inflammatory drug containing an anti-inflammatory agent, a remedy for athlete's foot or a beetle containing an anti-fungal agent, and the like can be mentioned. Thus, the skin external medicine of the present invention, as a component other than the above-mentioned polysaccharide, various medicinal components such as antihistamines, steroid hormones, bactericides, antibiotics, anti-inflammatory agents, antifungal agents, etc. are appropriately selected and blended. It

In addition to the above components, the skin external medicine of the present invention includes a transdermal absorption enhancer such as Azone, which is usually blended appropriately with skin external pharmaceuticals, and a water component described in detail above as a component of the cosmetic composition. , Hydrocarbons, esters, triglycerides, higher alcohols, higher fatty acids, polyhydric alcohols, surfactants, lower alcohols, thickeners, preservatives, powders, antioxidants, UV absorbers , PH adjuster,
It can be produced according to a usual method for producing a skin external medicine by using various components such as a chelating agent and a dye.

[0030]

Embodiments of the present invention will be described below. First,
Examples of cosmetics will be described. The amounts of the cosmetics used in the examples are all parts by weight. Further, in the following examples, duran gum was used as a polysaccharide having glucose, glucuronic acid and rhamnose as constituent sugars produced by Pseudomonas erodia, but these were all kelcogels manufactured by Merck.

[0031]

Examples 1 to 7 Cream Creams were prepared based on the formulations shown in Table 1. That is,
The components A and B shown in Table 1 were heated and dissolved at 80 ° C., respectively, and then the component A was gradually added to the component B with stirring to emulsify and cool to obtain a cream.

For comparison, among the ingredients of the cream of Example 2, the cream in which the kercogel was replaced with agar (Comparative Example 1), the cream in which the kercogel was replaced with gelatin (Comparative Example 2), and the kelcogel with POE ( 20) A cream substituted with oleyl ether (Comparative Example 3) was produced by the same production method as described above.

[0033]

[Table 1]

<Evaluation of Cream of the Present Invention> Using the creams obtained in each of the above Examples and Comparative Examples, a usability / feeling test and a makeup retention test were conducted to evaluate the cream of the present invention.

(1) Test of Usability and Feeling The sensory evaluation of usability and feel of the creams obtained in Examples 1 to 7 and Comparative Examples 1 to 3 was conducted. Four expert panelists use each cream, and these creams have good spreadability, ease of removal (evaluation items for usability), moist feeling, and refreshing feeling (evaluation items for usability). The item was evaluated on a scale of 5 from very good (5 points) to very bad (1 point), and the average value of 4 persons was used as the score of the cream. Table 2 shows the results.

[0036]

[Table 2]

From these results, the creams of Examples were used in comparison with the conventional surfactant-free creams obtained in Comparative Examples and creams in which the polysaccharide of the emulsion composition of the present invention was replaced with a surfactant. It is clear that it has excellent properties and usability.

(2) Makeup lasting test With respect to the creams obtained in the above Examples 1 to 7 and Comparative Examples 1 to 3, the action of the make-up cosmetics applied on the creams to makeup lasting was examined. That is, each cream was applied to the upper arm, and a cream foundation obtained in the same manner as in Comparative Example 6 described later was applied to the upper arm to make it resistant to rubbing under running water and liquid paraffin application. We had four specialist panelists evaluate us. The evaluation was carried out on a 5-point scale, with a very good make-up lasting 5 points and a very poor make-up lasting 1 point, and the average value of 4 persons was used as the score of the cream. The results are shown in Table 3.

[0039]

[Table 3]

From these results, it can be seen that the creams of Examples containing no surfactant have significantly improved makeup retention as compared with the cream of Comparative Example 3 containing a surfactant. In addition, since the creams of Examples having improved "spread" and "easiness of removal" have excellent adhesiveness, Comparative Examples 1 and 2
It can also be seen that the makeup retention is improved compared to the conventional surfactant-free cream obtained in.

[0041]

Examples 8 to 11 Cream foundation A cream foundation was prepared based on the formulation shown in Table 4. That is, the components A and B shown in Table 4 were each heated and dissolved at 80 ° C., and then the component C was dispersed in the component B,
Then, the component A was gradually added to this with stirring to emulsify it and cooled to obtain a cream foundation.

For comparison, the cream foundation in which the kercogel was replaced with agar (Comparative Example 4) and the cream foundation in which the kercogel was replaced with gelatin (Comparative Example 5) in the formulation components of the cream foundation of Example 8 were described above. Each was manufactured by the same manufacturing method as described above. Furthermore, a conventional oil-in-water foundation having a blending component shown in Table 5 (Comparative Example 6) and a conventional high internal phase water-in-oil foundation having a blending component shown in Table 6 (Comparative Example 7) were prepared in the same manner as above. And compared with the cream foundation of the example.

[0043]

[Table 4]

[0044]

[Table 5]

[0045]

[Table 6]

<Evaluation of Cream Foundation of the Present Invention> Using the cream foundations obtained in Examples 8 to 11 and Comparative Examples 4 to 7, a makeup retention test was conducted to evaluate the cream foundation of the present invention. That is, each cream foundation was applied to the upper arm portion, and four specialized panelists evaluated the difficulty of breaking it against rubbing under running water and applying liquid paraffin. The evaluation was carried out on a 5-point scale, in which the makeup foundation was very good and the makeup makeup retention was very bad, and the average of 4 persons was used as the score of the cream foundation. Table 7 shows the results.

[0047]

[Table 7]

From these results, the cream foundations of the examples are not only significantly improved in makeup retention as compared with the cream foundation of the comparative example 6 containing a surfactant but also obtained in the comparative examples 4 and 5. It can be seen that the makeup retention is further improved compared to the conventional surfactant-free cream foundation using the organic polymer gelling agent and the high internal phase water-in-oil foundation of Comparative Example 7.

Next, examples of the external medicine for skin will be described. The blending amount used in the following examples is% by weight.

[0050]

[Examples 12 to 15] External preparation for skin An external preparation for skin was prepared based on the formulation of Table 8. That is, each of the components A and B in Table 8 was heated and dissolved at 80 ° C., then the component A was gradually added to the component B while stirring to emulsify and cool to obtain a skin external preparation.

For comparison, an external antifungal skin preparation (Comparative Example 8) was prepared by mixing 1% by weight of bifonazole with hydrophilic softener prepared in the same manner as the hydrophilic ointment described in Japanese Pharmacopoeia.

[0052]

[Table 8]

<Evaluation of the external preparation for skin of the present invention> The antifungal external preparation obtained in Example 13 and the antifungal external preparation obtained in Comparative Example 8 were tested for bactericidal action. . That is, each of the above antifungal skin external preparations
Take one by g, planting the conidia of Trichophyton Mentha Gros Fight by 2 × 10 ⁵ cells in this, respectively, 14
After a day, the state of survival of the conidia was determined by staining.

As a result, almost no living cells were observed in the antifungal external preparation for skin of Example 13, but a small amount of the bacteria was alive in the external preparation for antifungal skin of Comparative Example 8. . From these results, it can be seen that the antifungal external preparation of Example 13 is superior to the antifungal external preparation of Comparative Example 8 in infiltrating the antifungal agent bifonazole through the cell membrane.

[0055]

INDUSTRIAL APPLICABILITY The emulsified composition of the present invention contains a polysaccharide produced by Pseudomonas erodia, which has glucose, glucuronic acid and rhamnose as constituent sugars, thereby imparting an excellent usability to the composition. In addition, the content of the surfactant in the composition can be reduced without impairing usability and without affecting the emulsifier form. If it becomes possible to reduce the content of the surfactant in the emulsified composition in this way, in cosmetics, problems such as makeup deterioration and reduced safety due to the surfactant may be caused. In the topical drug, it is possible to effectively solve problems such as loss of storability in the skin and deterioration of safety due to a surfactant without lowering usability of the emulsified composition.

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Claims (5)

[Claims] 1. An emulsified composition containing a polysaccharide produced by Pseudomonas erodia, which comprises glucose, glucuronic acid and rhamnose as a constituent sugar. 2. A polysaccharide is represented by the general formula (I) [→
3) -β-D-glucose (1 → 4) -β-D-glucuronic acid (1 → 4) -β-D-glucose (1 → 4) -α-L
An emulsified composition according to claim 1, which is a polysaccharide having rhamnose (1 →) as a repeating unit. (However, n represents an integer.) 3. The emulsified composition according to claim 1, wherein the content of the polysaccharide is 0.1 to 5% by weight based on the total amount of the composition. 4. The emulsion composition according to claim 1, which is a cosmetic. 5. The emulsion composition according to any one of claims 1 to 3, which is a skin external medicine.