JP3294758B2 - Gel emulsion composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to an emulsified composition, and more particularly, to an emulsified composition suitable for cosmetics or pharmaceuticals in which the amount of a surfactant is reduced.

[0002]

2. Description of the Related Art In cosmetics and external dermatological drugs, surfactants emulsify or solubilize water and oily components,
In order to stably disperse the powder component in the base material, and in a makeup remover, it was an indispensable component that was blended in order to dissolve, disperse, and remove dirt. However, on the other hand, surfactants cannot be said to be components that are preferable in terms of safety when blended in the above-mentioned cosmetics or external medicine for skin. This is because the surface active action of the surfactant acts usefully as described above, and at the same time, it is easy to cause irritation to the skin. Also, the surfactant is
Because it has both lipophilic and hydrophilic properties,
It is said that it does not have a very good effect on the long-lasting makeup makeup. Further, in the case of a makeup remover such as a cleansing agent, redness or the like may be caused by a synergistic effect of irritation caused by a surfactant remaining on the skin without being wiped off and irritation caused by friction at the time of wiping.

[0003] In view of such a situation, various methods have been tried so far for the purpose of reducing the amount of a surfactant to be incorporated into cosmetics or external medicines for skin. Examples of the above method include a dosage form in which an oil component is uniformly dispersed in a bentonite-water gel and a high internal phase W / O in which a large amount of an aqueous phase is included in an oil gel composed of sugar-polyglycerin ester-hydrocarbon.
Emulsification with a self-emulsifying thickener such as an emulsion or a long-chain alkyl acrylate polymer is exemplified.

[0004] By these methods, emulsification without using a surfactant or emulsification in which the amount of a compounded surfactant is remarkably reduced becomes possible. However, in the case of bentonite, gelation does not stop and the emulsion is solidified in several years. There is a problem that the high internal phase W / O emulsion has a low degree of freedom of the formulation components, and the emulsification by the self-emulsifying type thickener causes the powder to aggregate due to the effect of the thickener. There is a problem that it is difficult to use in a foundation system because it is easy to perform.

In the case of emulsification using an organic polymer gelling agent, there has been known a technique in which an oil component is dispersed and emulsified in agar or gelatin. Thus, although a moist and moist or refreshing desirable feeling can be obtained, there is a problem that functions such as a washing function and a penetrating action are impaired due to the small amount of the surfactant. Furthermore, the emulsion using agar or gelatin has a problem in usability due to tattering when picked up. Therefore, in an emulsified composition used for cosmetics or external medicine for skin, etc., while maintaining an emulsified dosage form, the cleaning properties inherent in the usability and the emulsified composition,
There has been a demand for a method of reducing the amount of a surfactant to be incorporated without impairing functions such as osmosis.

On the other hand, polysaccharides containing glucose, glucuronic acid and rhamnose as constituent sugars represented by the following general formula (I) which can be produced by microorganisms such as Pseudomonas aerodia are used as gelling agents for foods and the like. However, there is no report that an emulsified composition having no problem in usability or emulsifiability was obtained by using it in an emulsified composition.

[0007]

DISCLOSURE OF THE INVENTION The present invention has been made from the above-mentioned viewpoints, has excellent usability, and reduces the amount of a surfactant to be used without impairing the usability or the function inherently possessed by the emulsified composition. It is an object of the present invention to provide an emulsified composition such as a cosmetic or a topical skin drug.

[0008]

Means for Solving the Problems The present inventors have conducted intensive studies in order to solve the above problems, and as a result, have found that
By mixing (1) a specific polysaccharide produced by Pseudomonas aerodia, (2) a volatile oil agent, and (3) a water-insoluble polymer powder having a carbonyl group, a favorable feeling in use is obtained, Further, they have found that the amount of the surfactant can be reduced without impairing the functions of the emulsified composition inherently having cleaning properties and penetrating effects while maintaining the emulsified dosage form, and completed the present invention. .

That is, the present invention relates to (1) Pseudomonas
Glucose produced by Erodia, a polysaccharide having glucuronic acid and rhamnose as constituent sugars, and (2) a volatile oil agent,
(3) a water-insoluble polymer powder having a carbonyl group.

Here, Pseudomonas used in the present invention.
The polysaccharide produced by Erodia means a polysaccharide that can be produced by Pseudomonas aerodia. That is, the polysaccharide used in the present invention is Pseudomonas
It is not limited to the polysaccharides produced by Erodia, and the same polysaccharides produced by microorganisms other than Pseudomonas erodia can also be used in the present invention.

The polysaccharide contained in the emulsion composition of the present invention is specifically represented by the following general formula (I) [→
3) -β-D-glucose (1 → 4) -β-D-glucuronic acid (1 → 4) -β-D-glucose (1 → 4) -α-L
A polysaccharide having rhamnose (1 →) as a repeating unit.

[0012]

Embedded image

(Wherein, n represents an integer.) In the polysaccharide represented by the above general formula (I) used in the present invention, n in the formula represents an integer. Is 2 to 4000, and 10 to 10
00, more preferably 20.
~ 500.

The volatile oil used in the emulsified composition of the present invention is not particularly limited as long as it is a liquid which is not mixed with water at an arbitrary ratio, that is, an oil which has the property of volatilizing at room temperature. Can be. Specific examples include an oil agent having a boiling point of less than 200 ° C. under atmospheric pressure, and more specifically, dimethylpolysiloxane having a viscosity of 0.1 to 10 centistokes and cyclic dimethyl of a 3 to 6-mer. Examples thereof include polysiloxane, branched hydrocarbons having less than 20 carbon atoms, and esters having less than 12 total carbon atoms. Further, one of these volatile oil agents may be used alone or as a mixture of two or more thereof in the emulsified composition of the present invention.

The water-insoluble polymer powder having a carbonyl group used in the emulsion composition of the present invention is not particularly limited as long as it is a polymer compound having a carbonyl group in its molecular structure and is insoluble in water. Specifically, cellulose powder, water-insoluble polysaccharide powder such as starch powder, silk powder, water-insoluble protein powder such as cowhide powder,
Examples include polyamide resin powder such as nylon powder, acrylic resin powder such as polymer powder of acrylic acid, methacrylic acid and esters thereof, and copolymer powder thereof. One of these water-insoluble polymer powders having a carbonyl group may be used alone or as a mixture of two or more in the emulsion composition of the present invention. Among them, cellulose powder, silk powder, cow leather powder and the like are preferably used in the emulsified composition of the present invention.

The above polysaccharide in the emulsion composition of the present invention,
The content of the volatile oil agent and the water-insoluble polymer powder having a carbonyl group is preferably 0.1 to 5% by weight based on the total amount of the polysaccharide, and the content of the volatile oil agent The amount is preferably 1 to 90% by weight based on the total amount of the composition, and the water-insoluble polymer powder having a carbonyl group is preferably 0.1 to
Preferably it is 20% by weight.

The emulsified composition of the present invention contains the above-mentioned polysaccharide, a volatile oil agent, a water-insoluble polymer powder having a carbonyl group, and a base component contained in an ordinary emulsified composition.
Further, it optionally contains a surfactant and various components appropriately selected according to various uses and purposes. In a normal emulsified composition, the base component is composed of an aqueous phase component and an oil phase component. In the emulsified composition of the present invention, the oil phase component can be composed of the volatile oil and the other oil. It is also possible to use only the volatile oil agent. Such an emulsified composition of the present invention comprises the above-mentioned polysaccharide in an aqueous phase component, a volatile oil agent in an oil phase component, and a water-insoluble polymer powder having a carbonyl group in either of them. Can be produced in the same manner as in a normal emulsion composition.

Specific examples of the emulsified composition of the present invention include cosmetics and external medicines for skin. The emulsified composition of the present invention comprises, as described above, glucose produced by Pseudomonas erodia, a polysaccharide having glucuronic acid and rhamnose as constituent sugars, a volatile oil agent, and a water-insoluble polymer powder having a carbonyl group, What is contained, by containing these, it is possible to impart a moist and moist or refreshing preferable feeling of use to the composition, furthermore, the washing action and the inherently possessed by the emulsified composition The content of the surfactant in the composition can be reduced without impairing functions such as osmosis.
Further, it is also possible to improve the usability by improving the tattered feeling which has been a problem in the emulsified composition using the conventional organic polymer gelling agent. The emulsified composition of the present invention does not hinder the emulsified dosage form by containing these components.

If it becomes possible to reduce the amount of the surfactant in the emulsified composition as described above, in cosmetics, problems such as makeup collapse caused by the surfactant and a decrease in safety are reduced. In addition, in external medicines for skin, problems such as loss of storability in the skin due to surfactants and reduction in safety are effectively achieved without lowering the intrinsic functions and usability of the respective emulsified compositions. Can be solved.

[0020]

Embodiments of the present invention will be described below. (1) Emulsified Composition of the Present Invention The emulsified composition of the present invention comprises (1) a polysaccharide comprising glucose, glucuronic acid and rhamnose produced by Pseudomonas aerodidia, (2) a volatile oil agent, 3) a water-insoluble polymer powder having a carbonyl group.

The polysaccharides comprising glucose, glucuronic acid and rhamnose produced by Pseudomonas aerodidia used in the present invention are as described above.
In order to obtain such a polysaccharide used in the present invention, for example, a microorganism having the ability to produce the polysaccharide may be cultured, and the target polysaccharide may be separated and purified from the culture. More specifically, by inoculating Pseudomonas erodia or the like into a general fermentation stock solution and performing normal fermentation, and separating and purifying the polysaccharide from the obtained fermentation product by a normal method such as centrifugation or chromatography. The polysaccharide can be produced. In the present invention, it is also possible to use a culture containing the polysaccharide or a crude product in the course of purification. Further, since many of the above polysaccharides are commercially available as products, they can be used in the present invention. For example, as a polysaccharide represented by the above general formula (I) preferably used in the present invention, gellan gum, a fermentation product of Pseudomonas aerodia, is commercially available from Merck, USA under the trade name Kelcogel.

The preferred content of the above polysaccharide in the emulsion composition of the present invention is 0.1 to 5% by weight, and 0.5 to 4% by weight.
More preferably, the content is set to 1 wt%, more preferably 1 to 3 wt%.

The volatile oil used in the emulsified composition of the present invention is not particularly limited, as long as it has the property of volatilizing at room temperature as described above. Specific examples of the oil agent that evaporates at room temperature include oil agents having a boiling point of less than 200 ° C. under atmospheric pressure. Such volatile oils are generally used in cosmetics and external medicines for skin, and these can be used in the present invention.

More specifically, as the volatile oil agent,
Examples thereof include dimethylpolysiloxane having a viscosity of 0.1 to 10 centistokes, cyclic dimethylpolysiloxane of 3 to 6 mer, branched hydrocarbon having less than 20 carbon atoms, and ester having less than 12 total carbon atoms. Furthermore, carbon number 20
Examples of the branched hydrocarbons include isononane, isodecane, isoundecane, isododecane, polyisobutene having a carbon number of less than 20 and light liquid isoparaffin which is a mixture of several kinds thereof. Octanate, methyl isooctanoate, diethyl adipate and the like can be mentioned. The emulsion composition of the present invention can contain one of these alone or a mixture of two or more thereof.

These volatile oil agents can be produced according to a usual production method, but since many of them are commercially available as products, they can be used in the present invention. As such a commercially available product, for example, a viscosity of 0.
Silicone KF96-1c as 1 to 10 centistokes dimethylpolysiloxane. s. (Manufactured by Shin-Etsu Chemical Co., Ltd.) and silicone DC345 (manufactured by Dow Corning Toray Co., Ltd.) as a tri- to hexameric cyclic dimethylpolysiloxane, and light-flowing branched hydrocarbons having less than 20 carbon atoms. Shellsol 71 as isoparaffin
(Manufactured by Matsumoto Pharmaceutical Co., Ltd.) and Isopar G (manufactured by Exxon Chemical Co., Ltd.).

The preferred content of the volatile oil agent in the emulsified composition of the present invention is 1 to 90% by weight,
More preferably, the content is 80% by weight.
More preferably, the content is 70% by weight.

The water-insoluble polymer powder having a carbonyl group used in the emulsion composition of the present invention is not particularly limited as long as it is a polymer compound having a carbonyl group in the molecular structure and is insoluble in water. Specific examples include water-insoluble polysaccharide powder, water-insoluble protein powder, polyamide powder, acrylic resin powder, and the like. One of these water-insoluble polymer powders having a carbonyl group may be used alone or as a mixture of two or more in the emulsion composition of the present invention.

Further, as the above-mentioned water-insoluble polymer powder having a carbonyl group, more specifically, as water-insoluble polysaccharide powder, cellulose powder, starch powder, etc., as water-insoluble protein powder, silk powder, cow leather powder, etc. As a polyamide powder, nylon powder or the like as an acrylic resin powder, acrylic acid, methacrylic acid and polymer powders of these esters and copolymer powders thereof, for example, methyl acrylate polymer, ethyl acrylate polymer, methyl methacrylate polymer,
Ethyl methacrylate polymer, methyl acrylate
Powders such as methyl methacrylate copolymer and methyl methacrylate-ethylene glycol dimethacrylate copolymer can be given.

Further, among these, cellulose powder, silk powder, cow leather powder and the like are more preferably used in the emulsified composition of the present invention. The water-insoluble polymer powder having a carbonyl group used in the present invention can be produced according to a usual production method.However, since there are many commercially available products, these can be used in the present invention. is there. Examples of such commercially available products include silk powder (manufactured by Silk Development Laboratories) and the like as silk powder, protein powder (manufactured by Idemitsu Petrochemical Co., Ltd.) and the like as cowhide leather powder, and Toray Nylon Powder SP as nylon powder. -500 (manufactured by Toray Industries, Inc.) and the like, and methyl methacrylate polymer such as Julimer MB-1 (manufactured by Nippon Pure Chemical Industries, Ltd.) and methyl methacrylate-
Examples of the ethylene glycol dimethacrylate copolymer include Chinese bead (Matsumoto Yushi Seiyaku).

The preferred content of the water-insoluble polymer powder having a carbonyl group in the emulsified composition of the present invention is as follows:
The content is 0.1 to 20% by weight, preferably 1 to 15% by weight, and more preferably 3 to 10% by weight.

The emulsion composition of the present invention contains the above-mentioned polysaccharide, volatile oil agent, water-insoluble polymer powder having a carbonyl group, and a base component contained in an ordinary emulsion composition.
Further, it optionally contains a surfactant and various components appropriately selected according to various uses and purposes. These polysaccharides,
Various components other than the volatile oil agent and the water-insoluble polymer powder having a carbonyl group vary depending on the use, purpose, and the like of the emulsified composition of the present invention. Is performed for each composition. In addition, these various components can be contained in the emulsified composition of the present invention at a content that does not impair the effects of the present invention. The base component in the emulsified composition of the present invention comprises an aqueous phase component and an oil phase component in the same manner as the base component of a normal emulsified composition. You may comprise only the said volatile oil agent, or you may comprise the said volatile oil agent and the combination of other oil agents.

The surfactant may be optionally added to the emulsion composition of the present invention as described above. In the present invention, the polysaccharide, the volatile oil agent, and the water-insoluble polymer powder having a carbonyl group are contained. This makes it possible to obtain a good emulsion with a smaller amount of a surfactant than a normal emulsion composition. Further, in the present invention, an emulsified composition containing no surfactant can be prepared as required.

Such an emulsified composition of the present invention comprises the above-mentioned polysaccharide in an aqueous phase component, a volatile oil agent in an oil phase component, and a water-insoluble polymer powder having a carbonyl group in either of them. Except for mixing, in the same manner as a normal emulsified composition, for example, an oil phase component containing a volatile oil and an aqueous phase component containing the above polysaccharide are heated to about 70 to 90 ° C., respectively. A water-insoluble polymer powder having a crab carbonyl group can be dispersed, mixed, stirred and emulsified, and then cooled, for example.

Specific examples of such an emulsified composition of the present invention include cosmetics and skin external medicines. The embodiments will be described below in the order of the cosmetic and the external medicine for skin of the present invention.

(2) Cosmetic of the Present Invention The cosmetic to which the emulsified composition of the present invention can be applied is not particularly limited as long as it is a cosmetic to which an emulsified dosage form can be applied. And the like, makeup cosmetics such as foundations, hair cosmetics such as hair creams, and systemic cosmetics such as body creams.

As described above, in the cosmetic of the present invention,
A good emulsion can be obtained by adding a surfactant in an amount smaller than usual or without adding a surfactant, but this makes it possible to obtain cosmetics derived from surfactants which have been problematic in conventional emulsified cosmetics. Collapse and reduction in safety can be solved. In addition, the cosmetic of the present invention has a refreshing feeling of use, and has improved tattering when taken by hand, which has been a problem with emulsion compositions using conventional organic polymer gelling agents. The sex is getting better.

When the cosmetic of the present invention is used as a basic cosmetic, a cleansing agent or the like can exhibit a cosmetic removing effect comparable to that of the conventional one even though the surfactant is reduced. When used as a foundation, it is possible to provide a so-called all-in-one foundation that does not require makeup suppression with powder or the like as a product with good makeup durability. Also, if used as a hair cosmetic,
It is possible to provide a hair styling free of stickiness. Among such cosmetics of the present invention, those to which the emulsion composition of the present invention is more preferably applied are cosmetic removers such as cleansing ingredients.

Further, the cosmetic of the present invention can be prepared by using the above-mentioned polysaccharide, volatile oil agent, water-insoluble polymer powder having a carbonyl group, and various other components as described below. It can be manufactured according to

The components to be added to the cosmetic of the present invention in addition to the polysaccharide, the volatile oil agent, and the water-insoluble polymer powder having a carbonyl group are usually water to be added to the cosmetic;
Hydrocarbons such as petrolatum, squalane and microcrystalline wax; esters such as jojoba oil, gay wax and carnauba wax; triglycerides such as olive oil and tallow; higher alcohols such as cetanol, oleyl alcohol and stearyl alcohol; stearic acid; Higher fatty acids such as oleic acid; polyhydric alcohols such as glycerin, propylene glycol and 1,3-butanediol; lower alcohols such as ethanol and propanol;
Non-volatile silicones; Nonionic surfactants such as fatty acid monoglyceride and pooxyethylene hydrogenated castor oil; Anionic surfactants such as sodium lauryl sulfate and alkyl sulfosuccinate; Cationic surfactants such as quaternary alkylamine salts; Alkyl betaine Thickeners such as gum arabic and carboxyvinyl polymer; Preservatives such as paraben and chlorhexidine gluconate; Powders such as talc, silica gel and titanium oxide; Antioxidants such as tocopherol and butylhydroxytoluene Agent;
UV absorbers such as para-aminobenzoic acid derivatives and benzophenone derivatives; humectants such as polyethylene glycol and hyaluronic acid; anti-inflammatory agents such as dipotassium glycyrrhizinate; pH adjusters such as citrate and acetate; chelating agents;
Perfume; pigment; medicinal ingredients for various purposes such as placenta extract, ginseng extract, sterol glycoside, and the like.

(3) External medicine for skin of the present invention The external medicine for skin to which the emulsified composition of the present invention can be applied is not particularly limited as long as it is an external medicine for skin to which an emulsified dosage form can be applied. In the external preparation for skin of the present invention, a good emulsion can be obtained by adding a surfactant in an amount smaller than usual or without adding a surfactant. Thus, it is possible to solve the problems such as the loss of the ability to be retained in the skin and the decrease in the safety derived from the surfactant. Also,
If the system does not contain a surfactant, it can be suitably applied to a matrix such as a patch or the like in which the safety under embolization is very important. Further, like the above-mentioned cosmetics, the usability has been improved.

Examples of the external preparation for skin of the present invention include antipruritic drugs containing antihistamines and steroid hormones, antisuppuration drugs containing fungicides and antibiotics, and the like.
An anti-inflammatory drug containing an anti-inflammatory agent, a drug for treating athlete's foot or a tamushi drug containing an anti-fungal agent, and the like can be given. As described above, the pharmaceutical composition for external use on the skin of the present invention contains, as components other than the above polysaccharides, volatile oils, and water-insoluble polymer powder having a carbonyl group, antihistamines, steroid hormones, bactericides, antibiotics, anti-inflammatory agents, Various medicinal ingredients such as fungicides are appropriately selected and blended.

In addition to the above-mentioned components, the dermatological preparation of the present invention may further comprise a percutaneous absorption enhancer such as azone which is usually appropriately added to the dermatological preparation, and water, which is described in detail as a compounding component of the cosmetic. , Hydrocarbons, esters, triglycerides, higher alcohols, higher fatty acids, polyhydric alcohols, surfactants, lower alcohols, thickeners, preservatives, powders, antioxidants, ultraviolet absorbers , PH adjuster,
It can be produced using various components such as a chelating agent and a pigment in accordance with a usual method for producing an external medicine for skin.

[0043]

Embodiments of the present invention will be described below. First,
Examples of cosmetics will be described. The amounts used in the examples of the cosmetics are all parts by weight. Further, in the following examples, juran gum was used as a polysaccharide containing glucose, glucuronic acid and rhamnose produced by Pseudomonas aerodia, and these were all Kelcogels manufactured by Merck.

[0044]

Examples 1-4 Creams Creams were prepared based on the formulation in Table 1. That is,
The components A and B shown in Table 1 are each heated and dissolved at 80 ° C., and then the component C is dispersed in the component B. Then, the component A is gradually added thereto while stirring to emulsify and cool to obtain a cream. Was.

For comparison, in the cream components of Example 2, a cream in which Kelcogel was replaced with agar (Comparative Example 1), a cream in which Kelcogel was replaced with gelatin (Comparative Example 2), and Kelcogel were POE ( 20) Cream substituted with oleyl ether (Comparative Example 3), cream substituted with Kelcogel on agar, crystalline cellulose substituted with water (Comparative Example 4), and cream substituted with volatile oil agent with liquid paraffin (Comparative Example 5) , Respectively, by the same manufacturing method as described above.

[0046]

[Table 1]

[0047]

Examples 5 to 8 Creams Creams were prepared based on the formulations shown in Table 2. That is,
The components A and B shown in Table 2 were each heated and dissolved at 80 ° C., and then the component C was dispersed in the component B. Then, the component A was gradually added thereto while stirring to emulsify and cooled to obtain a cream. Was.

[0048]

[Table 2]

<Evaluation of Cream of the Present Invention> Using the creams obtained in each of the above Examples and Comparative Examples, a test of usability and usability, a cosmetic durability test and a cleansing test were carried out, and the cream of the present invention was evaluated. evaluated.

(1) Test for Usability and Usability The creams obtained in Examples 1 to 8 and Comparative Examples 1 to 4 were subjected to a sensory evaluation of usability and usability. Four specialized panelists use each cream, and for these creams, 4 of good spreadability, ease of removal (evaluation items of usability), moist feeling, refreshing feeling (evaluation items of usability) The items were rated on a 5-point scale from very good (5 points) to very bad (1 point), and the average value of the four persons was used as the score of the cream. Table 3 shows the results.

[0051]

[Table 3]

From these results, the creams of the examples are creams obtained by replacing the polysaccharide of the emulsified composition of the present invention obtained in the comparative example with a conventional organic polymer gelling agent or surfactant, or have a high water insolubility. Compared to creams that do not contain molecular powder,
It is clear that the usability is excellent. Further, regarding the feeling of use, the creams of the examples are prepared by replacing the polysaccharide of the emulsified composition of the present invention obtained in the comparative example with a surfactant or by using a conventional organic polymer gelling agent. It is superior to a cream free of an activator, and it is understood that it is equal to or better than a cream in which the polysaccharide of the emulsified composition of the present invention is replaced with a conventional organic polymer gelling agent.

(2) Long-lasting test With respect to the creams obtained in the above Examples 1 to 8 and Comparative Examples 1 to 4, the effect of the makeup applied on the creams for long-lasting was examined. That is, each cream is applied to the upper arm portion, and a cream foundation obtained in the same manner as in Comparative Example 10 described later is applied thereon, so that the cream foundation is hardly disintegrated against rubbing under flowing water and liquid paraffin. Four expert panelists evaluated it. The evaluation was performed on a 5-point scale with 5 points for very good make-up and 1 point for very poor make-up, and the average value of the four persons was used as the score of the cream. Table 4 shows the results.

[0054]

[Table 4]

From these results, it can be seen that the cream of the example containing no surfactant has significantly improved cosmetic durability compared to the cream of Comparative Example 3 containing the surfactant. In addition, the creams of the examples in which “expansion” and “easiness of removal” were improved had excellent adhesiveness.
It can also be seen that the cosmetic composition of the emulsion composition of the present invention obtained in Steps 2 and 4 has a longer lasting makeup than the surfactant free cream containing no polysaccharide, water-insoluble polymer powder, or the like.

(3) Cleansing Test The creams obtained in Examples 1 to 8 and Comparative Example 5 were evaluated as cleansing ingredients. That is, the cream foundation obtained in the same manner as in Comparative Example 11 described below was applied to the inner part of the upper arm, and the creams were applied thereon, and the cream foundation was wiped off. At the time, the condition of the cream foundation was dropped very well by the naked eye to four expert panelists (5
5) according to the criteria of (point) to almost no drop (1 point)
The cream was rated on a scale, and the average value of the four persons was used as the cleansing property of the cream.

After the cream is wiped off, the cream is washed only with lukewarm water and the remaining condition of the cream is evaluated on a five-point scale according to the criteria of almost no remaining (5 points) to almost no drop (1 point), The average value of four persons was evaluated as the wash-off property of the cream. Table 5 shows the results.

[0058]

[Table 5]

From these results, it can be seen that the creams of the examples have excellent cleansing properties and very good wash-off properties as compared with creams in which the volatile oil of the emulsified composition of the present invention is replaced with liquid paraffin. I understand.

[0060]

Examples 9 to 12 Cream Foundation A cream foundation was prepared based on the formulation shown in Table 6. That is, the components A and B shown in Table 6 were each dissolved by heating at 80 ° C., and then the component C was dispersed in the component B.
Next, the component A was gradually added to the mixture while stirring to emulsify the mixture, followed by cooling to obtain a cream foundation. In addition,
In the components in the table, protein powder is a trade name of cow leather powder manufactured by Idemitsu Petrochemical Co., Ltd.

For comparison, in the ingredients of the cream foundation of Example 9, a cream foundation in which Kelcogel was replaced with agar (Comparative Example 6), a cream foundation in which Kelcogel was replaced with gelatin (Comparative Example 7), and Kelcogel Was prepared on agar, and a cream foundation in which silk powder was replaced by water (Comparative Example 8) and a cream foundation in which volatile oils were replaced by liquid paraffin (Comparative Example 9) were produced by the same production method as above. Further, a conventional oil-in-water foundation having the components shown in Table 7 (Comparative Example 10) and a conventional high internal phase water-in-oil foundation having the components shown in Table 8 (Comparative Example 11) were prepared in the same manner as described above. And compared with the cream foundation of Example.

[0062]

[Table 6]

[0063]

[Table 7]

[0064]

[Table 8]

<Evaluation of Cream Foundation of the Present Invention> Using the cream foundations obtained in each of the above Examples and Comparative Examples, a makeup durability test and a usability test as an all-in-one make-up cosmetic were carried out. The cream foundation was evaluated.

(1) Long-lasting makeup test The cream foundations obtained in Examples 9 to 12 and Comparative Examples 6 to 8, 10 and 11 were examined for long-lasting makeup. That is, each cream foundation was applied to the upper arm, and four expert panelists evaluated the difficulty of collapsing against rubbing under running water or liquid paraffin. The evaluation was performed on a 5-point scale with 5 points for very good make-up and 1 point for very poor make-up, and the average value of four persons was used as the score of the cream foundation. Table 9 shows the results.

[0067]

[Table 9]

From these results, the cream foundations of the examples were not only significantly improved in cosmetic durability as compared with the cream foundation of the comparative example 10 containing the surfactant, but also were obtained in the comparative examples 6 to 8. The cosmetic durability of the emulsion composition of the present invention is improved as compared with the surfactant-free cream foundation containing no polysaccharide, water-insoluble polymer powder, and the like, and the high internal phase water-in-oil foundation of Comparative Example 11. You can see that.

(2) Usability test as all-in-one make-up cosmetics The cream foundations obtained in the above Examples 9 to 12 and Comparative Examples 9 to 11 were used to evaluate the usability as all-in-one make-up cosmetics in terms of cosmetic finish and cosmetics. Was evaluated in terms of That is, as a comprehensive evaluation of the tactile sensation and the appearance, the finish when makeup was actually performed using each of the cream foundations described above was not required for four professional panelists (5).
Points) to 5 points in accordance with the criteria of (1 point) that required a powder for makeup suppression, and the average value of 4 persons was used as the score of the cosmetic finish of the cream foundation. In addition, the makeup was evaluated in five steps according to the criteria of no makeup (5 points) to under makeup (1 point) from the makeup paste and spread of the cream foundation. The average value of the person was evaluated as the cosmetic foundation of the cream foundation. Table 10 shows the results.

[0070]

[Table 10]

From these results, when the cream foundation obtained in the example was used, a cosmetic finish with a powdery feeling was obtained as compared with the cream foundation of the comparative example, and the cosmetic property was so low that under-makeup was not required. It is well understood that this cream foundation has excellent usability as an all-in-one foundation.

Next, examples of skin external preparations will be described. The amounts used in the following examples are% by weight.

[0073]

Examples 13 to 16 Skin external preparations were prepared based on the formulations shown in Table 11. That is, the components A and B in Table 11 were each heated and dissolved at 80 ° C., and then the component C was dispersed in the component B. Then, while stirring, the component A was gradually added thereto to emulsify, and then cooled and cooled. Agent was obtained.

For comparison, an antifungal skin preparation prepared by mixing 1% by weight of bifonazole with hydrophilic softener prepared in the same manner as the hydrophilic ointment described in the Japanese Pharmacopoeia (Comparative Example 1)
2) was produced.

[0075]

[Table 11]

<Evaluation of the external preparation for skin of the present invention> The antifungal external preparation obtained in Example 14 and the antifungal external preparation obtained in Comparative Example 12 were tested for bactericidal action. . That is, 1 g of each of the above-mentioned antifungal skin external preparations was taken, and 2 × 10 ⁵ conidia of Trichophyton mentagrophyte were planted in each of them, and
Four days later, the state of survival of the conidia was determined by staining.

As a result, almost no cells survived in the antifungal skin external preparation of Example 14, but slightly survived in the antifungal skin external preparation of Comparative Example 12. . The results show that the antifungal skin external preparation of Example 14 is superior to the antifungal skin external preparation of Comparative Example 12 in infiltrating the antifungal agent bifonazole through the cell membrane. From this, it can be said that the skin external preparations obtained in the examples did not impair the inherent penetrating function of the emulsion composition.

[0078]

The emulsified composition of the present invention comprises a polysaccharide comprising glucose, glucuronic acid and rhamnose produced by Pseudomonas erodia, a volatile oil agent, and a water-insoluble polymer powder having a carbonyl group. By containing the compound, it is possible to impart an excellent feeling of use to the composition, and without impairing the functions such as the washing action and the penetrating action that the emulsion composition originally has, and also to hinder the emulsification dosage form. Without that, it is possible to reduce the content of surfactant in the composition. If it becomes possible to reduce the amount of the surfactant in the emulsified composition in this way, in cosmetics, problems such as makeup collapse and reduced safety derived from the surfactant, In topical drugs, loss of skin retention due to surfactants,
Problems such as a decrease in safety can be effectively solved without lowering the intrinsic functions of the respective emulsified compositions.

Continuation of the front page (51) Int.Cl. ⁷ identification code FI // C08B 37/00 C08B 37/00 P (58) Field surveyed (Int. Cl. ⁷ , DB name) A61K 9/107 A61K 7/00 A61K 47/36

Claims (9)

(57) [Claims] 1. A polysaccharide comprising glucose, glucuronic acid and rhamnose produced by Pseudomonas aerodidia, (2) a volatile oil, and (3) a water-insoluble polymer powder having a carbonyl group. An emulsified composition containing: 2. The polysaccharide represented by the general formula (I) [→
3) -β-D-glucose (1 → 4) -β-D-glucuronic acid (1 → 4) -β-D-glucose (1 → 4) -α-L
2. The emulsion composition according to claim 1, which is a polysaccharide having rhamnose (1 →) as a repeating unit. (However, n represents an integer.) 3. The volatile oil agent has a boiling point of 2 at atmospheric pressure.
The emulsified composition according to claim 1 or 2, wherein the temperature is lower than 00 ° C. 4. The volatile oil agent is a dimethylpolysiloxane having a viscosity of 0.1 to 10 centistokes, a cyclic dimethylpolysiloxane of 3 to 6 mer, a branched hydrocarbon having less than 20 carbon atoms and a total of less than 12 carbon atoms. 1 selected from esters
The emulsified composition according to any one of claims 1 to 3, wherein the emulsified composition is a kind or two or more kinds. 5. The water-insoluble polymer powder having a carbonyl group is a water-insoluble polysaccharide powder, a water-insoluble protein powder,
The emulsion composition according to any one of claims 1 to 4, wherein the emulsion composition is at least one selected from polyamide powder and acrylic resin powder. 6. The emulsion composition according to claim 5, wherein the water-insoluble polymer powder having a carbonyl group is one or more selected from cellulose powder, silk powder, and bovine leather powder. 7. The content of the polysaccharide is 0.1 to 5% by weight based on the total amount of the composition, the content of the volatile oil agent is 1 to 90% by weight based on the total amount of the composition, The emulsion composition according to any one of claims 1 to 6, wherein the content of the water-insoluble polymer powder having a content of 0.1 to 20% by weight based on the total amount of the composition. 8. The emulsion composition according to claim 1, which is a cosmetic. 9. The emulsified composition according to claim 1, which is a drug for external use on the skin.