JP3351954B2 - Emulsion composition - Google Patents
Emulsion compositionInfo
- Publication number
- JP3351954B2 JP3351954B2 JP06656296A JP6656296A JP3351954B2 JP 3351954 B2 JP3351954 B2 JP 3351954B2 JP 06656296 A JP06656296 A JP 06656296A JP 6656296 A JP6656296 A JP 6656296A JP 3351954 B2 JP3351954 B2 JP 3351954B2
- Authority
- JP
- Japan
- Prior art keywords
- powder
- water
- present
- polysaccharide
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 30
- 229920003176 water-insoluble polymer Polymers 0.000 claims description 29
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- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 claims description 9
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims description 9
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 8
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- 102000004169 proteins and genes Human genes 0.000 claims description 6
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- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 claims 1
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- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
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- 239000002738 chelating agent Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
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- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
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- 230000001804 emulsifying effect Effects 0.000 description 2
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- 150000002430 hydrocarbons Chemical class 0.000 description 2
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- 229940057995 liquid paraffin Drugs 0.000 description 2
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- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
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- 239000003270 steroid hormone Substances 0.000 description 2
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- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、乳化組成物に関
し、詳しくは、界面活性剤の配合量が軽減された化粧料
あるいは医薬品に好適な乳化組成物に関する。[0001] The present invention relates to an emulsified composition, and more particularly, to an emulsified composition suitable for cosmetics or pharmaceuticals in which the amount of a surfactant is reduced.
【０００２】[0002]
【従来の技術】化粧料や皮膚外用医薬品において界面活
性剤は、水と油性成分を乳化あるいは可溶化させたり、
粉体成分を基剤に安定に分散させたりするために、ま
た、化粧落とし料においては、汚れを溶解・分散・脱離
させるために配合される必要不可欠な成分であった。し
かしながら、その一方で界面活性剤は、上記化粧料や皮
膚外用医薬品に配合する際に安全性上好ましい成分とは
言えなかった。これは、界面活性剤の有する界面活性作
用が上記の様に有用に作用すると同時に皮膚に対しては
刺激を発現させ易いためである。また、界面活性剤は、
親油性と親水性の両方の性質を兼ね備えているために、
メークアップ化粧料の化粧持ちにもあまり良い影響を与
えないと言われている。さらに、クレンジング料の様な
化粧落とし料では、拭き取りきれずに皮膚上に残存する
界面活性剤による刺激と拭き取りの際の摩擦による刺激
の相乗作用から発赤等を起こすこともあった。2. Description of the Related Art In cosmetics and external dermatological drugs, surfactants emulsify or solubilize water and oily components,
In order to stably disperse the powder component in the base material, and in a makeup remover, it was an indispensable component that was blended in order to dissolve, disperse, and remove dirt. However, on the other hand, surfactants cannot be said to be components that are preferable in terms of safety when blended in the above-mentioned cosmetics or external medicine for skin. This is because the surface active action of the surfactant acts usefully as described above, and at the same time, it is easy to cause irritation to the skin. Also, the surfactant is
Because it has both lipophilic and hydrophilic properties,
It is said that it does not have a very good effect on the long-lasting makeup makeup. Further, in the case of a makeup remover such as a cleansing agent, redness or the like may be caused by a synergistic effect of irritation caused by a surfactant remaining on the skin without being wiped off and irritation caused by friction at the time of wiping.
【０００３】この様な状況を反映して、これまでに化粧
料や皮膚外用医薬品に配合する界面活性剤量の減量を目
的として様々な方法が試みられてきた。前記方法の例と
して、ベントナイト−水のゲル中に油性成分を均一分散
した剤形や糖−ポリグリセリンエステル−炭化水素から
なる油性ゲル中に多量の水相を内包させた高内相Ｗ／Ｏ
エマルジョン、長鎖アルキルアクリル酸エステルポリマ
ー等の自己乳化型増粘剤による乳化等が挙げられる。[0003] In view of such a situation, various methods have been tried so far for the purpose of reducing the amount of a surfactant to be incorporated into cosmetics or external medicines for skin. Examples of the above method include a dosage form in which an oil component is uniformly dispersed in a bentonite-water gel and a high internal phase W / O in which a large amount of an aqueous phase is included in an oil gel composed of sugar-polyglycerin ester-hydrocarbon.
Emulsification with a self-emulsifying thickener such as an emulsion or a long-chain alkyl acrylate polymer is exemplified.
【０００４】これらの方法によって、界面活性剤によら
ない乳化や配合界面活性剤量を著しく減少させた乳化が
可能となったが、ベントナイト系についてはゲル化が止
まらず数年で乳化物が固化してしまうという問題があ
り、高内相Ｗ／Ｏエマルジョンについては処方成分の自
由度が少ないという問題があり、また、自己乳化型増粘
剤による乳化は増粘剤の影響で粉体が凝集し易くなるこ
とからファンデーション系では使いにくいという問題が
あった。[0004] By these methods, emulsification without using a surfactant or emulsification in which the amount of a compounded surfactant is remarkably reduced becomes possible. However, in the case of bentonite, gelation does not stop and the emulsion is solidified in several years. There is a problem that the high internal phase W / O emulsion has a low degree of freedom of the formulation components, and the emulsification by the self-emulsifying type thickener causes the powder to aggregate due to the effect of the thickener. There is a problem that it is difficult to use in a foundation system because it is easy to perform.
【０００５】また、有機高分子ゲル化剤を用いた乳化で
は、寒天やゼラチンを用いてこの中に油性成分を分散し
て乳化する技術が知られていたが、寒天やゼラチンを用
いた乳化物では、潤いのあるしっとりとしたあるいはさ
っぱりとした好ましい使用感が得られるものの、手に取
ったときにボロボロ感があり使用性に問題があった。そ
こで、化粧料や皮膚外用医薬品等に利用される乳化組成
物において、乳化剤形を維持しつつ、使用性を損なわず
に界面活性剤の配合量を減量する方法が求められてい
た。In the case of emulsification using an organic polymer gelling agent, there has been known a technique in which an oil component is dispersed and emulsified in agar or gelatin. Thus, although a moist, moist or refreshing favorable feeling can be obtained, there is a problem in usability due to a ragged feeling when picked up. Thus, there has been a demand for a method of reducing the amount of surfactant incorporated in an emulsified composition used for cosmetics, topical skin pharmaceuticals, etc., while maintaining the emulsified dosage form, without impairing the usability.
【０００６】一方、シュードモナス・エロディア等の微
生物が産生しうる後述の一般式（Ｉ）で表される様なグ
ルコース、グルクロン酸及びラムノースを構成糖とする
多糖類については、ゲル化剤として食品等に用いられる
ことは知られていたが、乳化組成物に使用して使用性や
乳化性に問題のない乳化組成物が得られたという報告は
ない。On the other hand, polysaccharides containing glucose, glucuronic acid and rhamnose as constituent sugars represented by the following general formula (I) which can be produced by microorganisms such as Pseudomonas aerodia are used as gelling agents for foods and the like. However, there is no report that an emulsified composition having no problem in usability or emulsifiability was obtained by using it in an emulsified composition.
【０００７】[0007]
【発明が解決しようとする課題】本発明は上記観点から
なされたものであり、使用感に優れ、使用性を損なわず
に界面活性剤の配合量が減量された化粧料、皮膚外用医
薬品等の乳化組成物を提供することを課題とする。DISCLOSURE OF THE INVENTION The present invention has been made from the above-mentioned viewpoints, and has excellent usability, and has a reduced amount of a surfactant without impairing usability. It is an object to provide an emulsion composition.
【０００８】[0008]
【課題を解決するための手段】本発明者らは、上記課題
を解決するために鋭意研究を行った結果、乳化組成物に
(1)シュードモナス・エロディアが産生する特定の多糖
類と、(2)カルボニル基を有する水不溶性高分子粉末
と、を配合することで、好ましい使用感が得られ、且つ
乳化剤形を維持しつつも使用性を損なうことなく界面活
性剤の配合量を減量できることを見出し、本発明を完成
させた。Means for Solving the Problems The present inventors have conducted intensive studies in order to solve the above problems, and as a result, have found that
By blending (1) a specific polysaccharide produced by Pseudomonas aerodia and (2) a water-insoluble polymer powder having a carbonyl group, a favorable feeling in use is obtained, and while maintaining an emulsified dosage form. They have found that the amount of the surfactant can be reduced without impairing the usability, and completed the present invention.
【０００９】すなわち本発明は、(1)シュードモナス・
エロディアが産生するグルコース、グルクロン酸及びラ
ムノースを構成糖とする多糖類と、(2)カルボニル基を
有する水不溶性高分子粉末と、を含有する乳化組成物で
ある。That is, the present invention relates to (1) Pseudomonas
An emulsified composition containing a polysaccharide composed of glucose, glucuronic acid and rhamnose produced by Erodia, and (2) a water-insoluble polymer powder having a carbonyl group.
【００１０】ここで、本発明に用いるシュードモナス・
エロディアが産生する前記多糖類とは、シュードモナス
・エロディアにより産生されうる多糖類を意味する。つ
まり、本発明に用いる前記多糖類は、シュードモナス・
エロディアが産生した多糖類に限定されるものではな
く、シュードモナス・エロディア以外の微生物によって
生産された前記多糖類と同様の多糖類も本発明に用いる
ことが可能である。Here, Pseudomonas used in the present invention.
The polysaccharide produced by Erodia means a polysaccharide that can be produced by Pseudomonas aerodia. That is, the polysaccharide used in the present invention is Pseudomonas
It is not limited to the polysaccharides produced by Erodia, and the same polysaccharides produced by microorganisms other than Pseudomonas erodia can also be used in the present invention.
【００１１】本発明の乳化組成物が含有する上記多糖類
として、具体的には、下記一般式（Ｉ）に示される［→
３）−β−D−グルコース（１→４）−β−D−グルクロ
ン酸（１→４）−β−D−グルコース（１→４）−α−L
−ラムノース（１→］を繰り返し単位とする多糖類を挙
げることができる。The polysaccharide contained in the emulsion composition of the present invention is specifically represented by the following general formula (I) [→
3) -β-D-glucose (1 → 4) -β-D-glucuronic acid (1 → 4) -β-D-glucose (1 → 4) -α-L
A polysaccharide having rhamnose (1 →) as a repeating unit.
【００１２】[0012]
【化２】 Embedded image
【００１３】（但し、ｎは整数を表す。） 本発明に用いる上記一般式（Ｉ）で示される多糖類にお
いて、式中のｎは整数を表すが、本発明において好まし
い多糖類のｎの数は、２〜４０００であり、１０〜１０
００であることがより好ましく、さらに好ましくは２０
〜５００である。(Wherein, n represents an integer.) In the polysaccharide represented by the above general formula (I) used in the present invention, n in the formula represents an integer. Is 2 to 4000, and 10 to 10
00, more preferably 20.
~ 500.
【００１４】本発明の乳化組成物に用いるカルボニル基
を有する水不溶性高分子粉末としては、分子構造中にカ
ルボニル基を有する高分子化合物であって水に不溶性の
粉末であれば特に制限されないが、具体的には、セルロ
ース粉末、デンプン粉末等の水不溶性多糖類粉末、シル
クパウダー、牛皮革粉末等の水不溶性タンパク質粉末、
ナイロンパウダー等のポリアミド粉末、アクリル酸、メ
タアクリル酸及びこれらのエステルのポリマー粉末やこ
れらの共重合体粉末等のアクリル樹脂粉末等を挙げるこ
とができる。これらのカルボニル基を有する水不溶性高
分子粉末は、１種が単独で又は２種以上が混合物として
本発明の乳化組成物に用いられる。また、これらのうち
でもセルロース粉末、シルクパウダー、牛皮革粉末等が
本発明の乳化組成物において好ましく用いられる。The water-insoluble polymer powder having a carbonyl group used in the emulsion composition of the present invention is not particularly limited as long as it is a polymer compound having a carbonyl group in the molecular structure and is insoluble in water. Specifically, cellulose powder, water-insoluble polysaccharide powder such as starch powder, silk powder, water-insoluble protein powder such as cowhide powder,
Examples include polyamide resin powder such as nylon powder, acrylic resin powder such as polymer powder of acrylic acid, methacrylic acid and esters thereof, and copolymer powder thereof. One of these water-insoluble polymer powders having a carbonyl group may be used alone or as a mixture of two or more in the emulsion composition of the present invention. Among them, cellulose powder, silk powder, cow leather powder and the like are preferably used in the emulsified composition of the present invention.
【００１５】本発明の乳化組成物における上記多糖類と
カルボニル基を有する水不溶性高分子粉末の含有量であ
るが、多糖類については組成物全量に対して０．１〜５
重量％であることが好ましく、また、カルボニル基を有
する水不溶性高分子粉末については組成物全量に対して
０．１〜２０重量％であることが好ましい。The content of the above polysaccharide and the water-insoluble polymer powder having a carbonyl group in the emulsion composition of the present invention is 0.1 to 5 parts by weight based on the total amount of the polysaccharide.
%, And the water-insoluble polymer powder having a carbonyl group is preferably 0.1 to 20% by weight based on the total amount of the composition.
【００１６】本発明の乳化組成物は、上記多糖類とカル
ボニル基を有する水不溶性高分子粉末とともに、通常の
乳化組成物が含有する基剤成分を含有し、さらに、界面
活性剤や各種用途、目的等にあわせて適宜選択される各
種成分を任意に含有する。通常の乳化組成物において、
基剤成分は水相成分と油相成分とからなり、この２相を
通常の方法で乳化することにより乳化組成物が得られ
る。本発明の乳化組成物においては、上記多糖類を水相
成分に、また、カルボニル基を有する水不溶性高分子粉
末を油相成分と水相成分のどちらかに、それぞれ配合す
る以外は、通常の乳化組成物と同様にして製造すること
ができる。The emulsion composition of the present invention contains, in addition to the above polysaccharide and a water-insoluble polymer powder having a carbonyl group, a base component contained in an ordinary emulsion composition, and further contains a surfactant, various uses, and the like. Various components appropriately selected according to the purpose and the like are arbitrarily contained. In a normal emulsion composition,
The base component is composed of an aqueous phase component and an oil phase component, and an emulsified composition is obtained by emulsifying these two phases by a usual method. In the emulsified composition of the present invention, except that the polysaccharide is added to the aqueous phase component, and the water-insoluble polymer powder having a carbonyl group is added to either the oil phase component or the aqueous phase component, It can be manufactured in the same manner as the emulsion composition.
【００１７】本発明の乳化組成物として具体的には、化
粧料や皮膚外用医薬品等を挙げることができる。本発明
の乳化組成物は、上記のようにシュードモナス・エロデ
ィアが産生するグルコース、グルクロン酸及びラムノー
スを構成糖とする多糖類と、カルボニル基を有する水不
溶性高分子粉末と、を含有するものであって、これらを
含有することで、組成物に潤いのあるしっとりとしたあ
るいはさっぱりとした好ましい使用感を付与することが
でき、さらに、使用性を損なうことなく組成物中の界面
活性剤の含有量を少なくすることができる。つまり、従
来の有機高分子ゲル化剤を用いて界面活性剤を減量した
乳化組成物において、この乳化組成物の有する好ましい
使用感を維持したまま、問題とされていたボロボロ感を
改善することができる。また、本発明の乳化組成物にお
いてはこれら成分を含有することで乳化剤形に支障を与
えることもない。Specific examples of the emulsified composition of the present invention include cosmetics and skin external medicines. The emulsified composition of the present invention contains a polysaccharide having glucose, glucuronic acid and rhamnose as constituent sugars produced by Pseudomonas aerodidia as described above, and a water-insoluble polymer powder having a carbonyl group. Therefore, by containing these, it is possible to impart a moist, moist or refreshing preferable feeling of use to the composition, and furthermore, the content of the surfactant in the composition without impairing the usability. Can be reduced. That is, in the emulsified composition in which the amount of the surfactant is reduced by using the conventional organic polymer gelling agent, it is possible to improve the ragged feeling which has been a problem while maintaining the preferable feeling of use of the emulsified composition. it can. Further, the emulsified composition of the present invention does not hinder the emulsified dosage form by containing these components.
【００１８】上記のようにして乳化組成物中の界面活性
剤の配合量を少なくすることが可能となれば、化粧料に
おいては界面活性剤に由来する化粧崩れや安全性の低下
などの問題を、また、皮膚外用医薬品においては界面活
性剤に由来する皮膚内貯留性の損失、安全性の低下等の
問題を、乳化組成物の使用性を低下させることなく有効
に解決することが可能となる。If it becomes possible to reduce the amount of the surfactant in the emulsified composition as described above, cosmetics suffer from problems such as makeup collapse and a decrease in safety due to the surfactant. In addition, in skin external preparations, it becomes possible to effectively solve problems such as loss of storage in the skin derived from surfactants, reduction in safety, etc. without lowering the usability of the emulsified composition. .
【００１９】[0019]
【発明の実施の形態】以下に本発明の実施の形態を説明
する。 （１）本発明の乳化組成物 本発明の乳化組成物は、(1)シュードモナス・エロディ
アが産生するグルコース、グルクロン酸及びラムノース
を構成糖とする多糖類と、(2)カルボニル基を有する水
不溶性高分子粉末と、を含有することを特徴とする。Embodiments of the present invention will be described below. (1) Emulsified Composition of the Present Invention The emulsified composition of the present invention comprises (1) a polysaccharide comprising glucose, glucuronic acid and rhamnose produced by Pseudomonas aerodidia, and (2) a water-insoluble compound having a carbonyl group. And a polymer powder.
【００２０】本発明に用いるシュードモナス・エロディ
アが産生するグルコース、グルクロン酸及びラムノース
を構成糖とする多糖類については上述した通りである。
この様な本発明に用いる多糖類を得るためには、例え
ば、前記多糖類を産生する能力を有する微生物を培養し
その培養物から目的とする多糖類を分離精製すればよ
い。より具体的には、シュードモナス・エロディア等を
一般的な発酵原液に接種し通常の発酵を行い、得られる
発酵産物より上記多糖類を遠心分離やクロマトグラフィ
ー等の通常の方法により分離精製することで上記多糖類
を製造することができる。本発明には、上記多糖類を含
有する培養物あるいは精製途中の粗製物等を用いること
も可能である。また、上記多糖類は製品として市販され
ているものも多いのでこれらを本発明に用いることも可
能である。例えば、本発明に好ましく用いられる上記一
般式（Ｉ）に表される多糖類としては、シュードモナス
・エロディアの発酵産物であるジェランガムが、米国メ
ルク社よりケルコゲルの商品名で市販されている。The polysaccharides comprising glucose, glucuronic acid and rhamnose produced by Pseudomonas aerodidia used in the present invention are as described above.
In order to obtain such a polysaccharide used in the present invention, for example, a microorganism having the ability to produce the polysaccharide may be cultured, and the target polysaccharide may be separated and purified from the culture. More specifically, by inoculating Pseudomonas erodia or the like into a general fermentation stock solution and performing normal fermentation, and separating and purifying the polysaccharide from the obtained fermentation product by a normal method such as centrifugation or chromatography. The polysaccharide can be produced. In the present invention, it is also possible to use a culture containing the polysaccharide or a crude product in the course of purification. Further, since many of the above polysaccharides are commercially available as products, they can be used in the present invention. For example, as a polysaccharide represented by the above general formula (I) preferably used in the present invention, gellan gum, a fermentation product of Pseudomonas aerodia, is commercially available from Merck, USA under the trade name Kelcogel.
【００２１】上記多糖類の本発明の乳化組成物における
好ましい含有量は０．１〜５重量％であり、０．５〜４
重量％の含有量とすることがより好ましく、１〜３重量
％の含有量とすることがさらに好ましい。The preferred content of the above polysaccharide in the emulsion composition of the present invention is 0.1 to 5% by weight, and 0.5 to 4% by weight.
More preferably, the content is set to 1 wt%, more preferably 1 to 3 wt%.
【００２２】本発明の乳化組成物に用いるカルボニル基
を有する水不溶性高分子粉末としては、分子構造中にカ
ルボニル基を有する高分子化合物であって水に不溶性の
粉末であれば特に制限されないが、具体的には、水不溶
性多糖類粉末、水不溶性タンパク質粉末、ポリアミド粉
末、アクリル樹脂粉末等を挙げることができる。これら
のカルボニル基を有する水不溶性高分子粉末は、１種が
単独で又は２種以上が混合物として本発明の乳化組成物
に用いられる。The water-insoluble polymer powder having a carbonyl group used in the emulsion composition of the present invention is not particularly limited as long as it is a polymer compound having a carbonyl group in the molecular structure and is insoluble in water. Specific examples include water-insoluble polysaccharide powder, water-insoluble protein powder, polyamide powder, acrylic resin powder, and the like. One of these water-insoluble polymer powders having a carbonyl group may be used alone or as a mixture of two or more in the emulsion composition of the present invention.
【００２３】また、上記カルボニル基を有する水不溶性
高分子粉末として、より具体的には水不溶性多糖類粉末
として、セルロース粉末、デンプン粉末等を、水不溶性
タンパク質粉末として、シルクパウダー、牛皮革粉末等
を、ポリアミド粉末としてナイロンパウダー等をアクリ
ル樹脂粉末として、アクリル酸、メタアクリル酸及びこ
れらのエステルのポリマー粉末やこれらの共重合体粉
末、例えば、メチルアクリレートポリマー、エチルアク
リレートポリマー、メチルメタアクリレートポリマー、
エチルメタアクリレートポリマー、アクリル酸メチル−
メタアクリル酸メチルコポリマー、メタアクリル酸メチ
ル−エチレングリコールジメタアクリレートコポリマー
等の粉末を挙げることができる。Further, as the water-insoluble polymer powder having a carbonyl group, more specifically, as water-insoluble polysaccharide powder, cellulose powder, starch powder, etc., as water-insoluble protein powder, silk powder, cow leather powder, etc. As a polyamide powder, nylon powder or the like as an acrylic resin powder, acrylic acid, methacrylic acid and polymer powders of these esters and copolymer powders thereof, for example, methyl acrylate polymer, ethyl acrylate polymer, methyl methacrylate polymer,
Ethyl methacrylate polymer, methyl acrylate
Powders such as methyl methacrylate copolymer and methyl methacrylate-ethylene glycol dimethacrylate copolymer can be given.
【００２４】さらに、これらのうちでもセルロース粉
末、シルクパウダー、牛皮革粉末等が本発明の乳化組成
物においてより好ましく用いられる。上記本発明に用い
るカルボニル基を有する水不溶性高分子粉末は、通常の
製造方法に従って製造することも可能であるが、製品と
して市販されているものも多いのでこれらを本発明に用
いることも可能である。この様な市販品としては、例え
ば、シルクパウダーとしてシルクパウダー（絹開発研究
所製）等を、牛皮革粉末としてプロテインパウダー（出
光石油化学（株）製）等を、ナイロンパウダーとして東
レナイロンパウダーＳＰ−５００（東レ（株）製）等
を、メチルメタアクリレートポリマーとしてジュリマー
ＭＢ−１（日本純薬製）等を、メタアクリル酸メチル−
エチレングリコールジメタアクリレートコポリマーとし
てチュウクウビーズ（松本油脂製薬製）等を挙げること
ができる。Further, among these, cellulose powder, silk powder, cow leather powder and the like are more preferably used in the emulsified composition of the present invention. The water-insoluble polymer powder having a carbonyl group used in the present invention can be produced according to a usual production method.However, since there are many commercially available products, these can be used in the present invention. is there. Examples of such commercially available products include silk powder (manufactured by Silk Development Laboratories) and the like as silk powder, protein powder (manufactured by Idemitsu Petrochemical Co., Ltd.) and the like as cowhide leather powder, and Toray Nylon Powder SP as nylon powder. -500 (manufactured by Toray Industries, Inc.) and the like, and methyl methacrylate polymer such as Julimer MB-1 (manufactured by Nippon Pure Chemical Industries, Ltd.) and methyl methacrylate-
Examples of the ethylene glycol dimethacrylate copolymer include Chinese bead (Matsumoto Yushi Seiyaku).
【００２５】本発明の乳化組成物における上記カルボニ
ル基を有する水不溶性高分子粉末の好ましい含有量は、
０．１〜２０重量％であり、１〜１５重量％の含有量で
あることがより好ましく、３〜１０重量％の含有量であ
ることがさらに好ましい。The preferred content of the water-insoluble polymer powder having a carbonyl group in the emulsion composition of the present invention is as follows:
The content is 0.1 to 20% by weight, preferably 1 to 15% by weight, and more preferably 3 to 10% by weight.
【００２６】本発明の乳化組成物は、上記多糖類とカル
ボニル基を有する水不溶性高分子粉末とともに、通常の
乳化組成物が含有する基剤成分（水相成分と油相成分）
を含有し、さらに、界面活性剤や各種用途、目的等にあ
わせて適宜選択される各種成分を本発明の効果を損なわ
ない範囲の含有量で任意に含有する。The emulsion composition of the present invention comprises, together with the above-mentioned polysaccharide and a water-insoluble polymer powder having a carbonyl group, base components (aqueous phase component and oil phase component) contained in a usual emulsion composition.
, And various components appropriately selected in accordance with a surfactant, various uses, purposes, and the like, in a content that does not impair the effects of the present invention.
【００２７】本発明の乳化組成物における基剤成分は通
常の乳化組成物の基剤成分と同様に水相成分と油相成分
とからなるが、本発明の乳化組成物において、この油相
成分を構成する油剤は、常温常圧下で液体の油剤である
ことが好ましい。これら油剤の好ましい含有量は、組成
物全量に対して１〜９０重量％であり、５〜８０重量％
の含有量であることがより好ましく、１０〜７０重量％
の含有量であることがさらに好ましい。また、基剤の水
相成分を構成する物質は、好ましくは水であり、好まし
い含有量は組成物全量に対して５〜８０重量％であり、
１０〜７０重量％の含有量であることがより好ましく、
２０〜６０重量％の含有量であることがさらに好まし
い。The base component in the emulsified composition of the present invention comprises an aqueous phase component and an oil phase component in the same manner as the base component of a normal emulsified composition. Is preferably a liquid oil at normal temperature and pressure. The preferable content of these oils is 1 to 90% by weight, and 5 to 80% by weight based on the total amount of the composition.
More preferably, the content is 10 to 70% by weight.
Is more preferable. The substance constituting the aqueous phase component of the base is preferably water, and the preferred content is 5 to 80% by weight based on the total amount of the composition,
More preferably, the content is 10 to 70% by weight,
More preferably, the content is 20 to 60% by weight.
【００２８】本発明の乳化組成物が含有する、上記多糖
類とカルボニル基を有する水不溶性高分子粉末以外の各
種成分については、基剤成分を含めて本発明の乳化組成
物の用途、目的等により様々であり、これらの詳細な説
明は後述の化粧料、皮膚外用医薬品の各組成物毎に行う
こととする。また、本発明の乳化組成物において界面活
性剤の配合は上述のように任意であり、本発明において
は上記多糖類とカルボニル基を有する水不溶性高分子粉
末を含有することで通常の乳化組成物より少ない量の界
面活性剤の配合で良好な乳化物を得ることができる。さ
らに、本発明においては必要に応じて界面活性剤を含有
しない乳化組成物を作製することも可能である。With respect to various components contained in the emulsion composition of the present invention other than the above-mentioned polysaccharide and water-insoluble polymer powder having a carbonyl group, the use and purpose of the emulsion composition of the present invention including the base component are included. The detailed description will be given for each composition of the cosmetic and the external medicine for skin described below. In the emulsion composition of the present invention, the surfactant may be added in an arbitrary manner as described above. In the present invention, a normal emulsion composition containing the polysaccharide and a water-insoluble polymer powder having a carbonyl group is contained. A good emulsion can be obtained with a smaller amount of a surfactant. Further, in the present invention, an emulsified composition containing no surfactant can be prepared as required.
【００２９】この様な本発明の乳化組成物は、上記多糖
類を水相成分に、また、カルボニル基を有する水不溶性
高分子粉末をそのどちらかに、それぞれ配合する以外
は、通常の乳化組成物と同様にして、例えば、油相成分
と上記多糖類を配合した水相成分とをそれぞれ７０〜９
０℃程度に加熱し、このどちらかにカルボニル基を有す
る水不溶性高分子粉末を分散させ、これらを混合し撹拌
乳化させ、その後、冷却する等の方法で製造することが
できる。The emulsified composition of the present invention is prepared by the usual emulsified composition except that the above-mentioned polysaccharide is added to the aqueous phase component and the water-insoluble polymer powder having a carbonyl group is added to either of them. In the same manner as the product, for example, the oil phase component and the aqueous phase component containing
It can be manufactured by heating to about 0 ° C., dispersing a water-insoluble polymer powder having a carbonyl group in either of them, mixing these, stirring and emulsifying, and then cooling.
【００３０】この様な本発明の乳化組成物として、具体
的には、化粧料や皮膚外用医薬品等を挙げることができ
る。以下、本発明の化粧料、皮膚外用医薬品の順にそれ
ぞれ実施の形態を説明する。Specific examples of such an emulsified composition of the present invention include cosmetics and skin external medicines. The embodiments will be described below in the order of the cosmetic and the external medicine for skin of the present invention.
【００３１】（２）本発明の化粧料 本発明の乳化組成物が適用可能な化粧料としては、乳化
型の剤形が適用できる化粧料であれば特に制限されるも
のではなく、例えば、クリーム等の基礎化粧品、ファン
デーション等のメークアップ化粧料、ヘアクリーム等の
頭髪化粧料、ボディークリーム等の全身用化粧料を挙げ
ることが可能である。(2) Cosmetic of the Present Invention The cosmetic to which the emulsified composition of the present invention can be applied is not particularly limited as long as it is a cosmetic to which an emulsified dosage form can be applied. And the like, makeup cosmetics such as foundations, hair cosmetics such as hair creams, and systemic cosmetics such as body creams.
【００３２】上述のように本発明の化粧料においては、
通常より少ない量の界面活性剤の配合であるいは界面活
性剤を配合せずに良好な乳化物が得られるが、これによ
り従来の乳化型化粧料において問題とされていた界面活
性剤に由来する化粧崩れや安全性の低下などを解決する
ことができる。この様に、本発明の化粧料は化粧持ち、
安全性に優れるが、また、本発明の化粧料はさっぱりし
た使用感を有しており、従来の有機高分子ゲル化剤を用
いた乳化組成物で問題とされていた手に取ったときのボ
ロボロ感も改善され使用性がよくなっている。As described above, in the cosmetic of the present invention,
A good emulsion can be obtained by adding a surfactant in an amount smaller than usual or without adding a surfactant, but this makes it possible to obtain cosmetics derived from surfactants which have been problematic in conventional emulsified cosmetics. Collapse and reduction in safety can be solved. In this way, the cosmetic of the present invention has makeup,
Although it is excellent in safety, the cosmetic of the present invention has a refreshing feeling of use, and when it is picked up by the hand, which has been a problem with an emulsified composition using a conventional organic polymer gelling agent. The ragged feeling is also improved and the usability is improved.
【００３３】また、本発明の化粧料は、上記多糖類とカ
ルボニル基を有する水不溶性高分子粉末と、以下に挙げ
るそれ以外の各種成分とを用いて通常の化粧料の製造方
法に従って製造することができる。The cosmetic of the present invention is produced by using the above-mentioned polysaccharide, a water-insoluble polymer powder having a carbonyl group, and various other components listed below in accordance with an ordinary cosmetic production method. Can be.
【００３４】本発明の化粧料に、上記多糖類とカルボニ
ル基を有する水不溶性高分子粉末以外に配合される成分
としては、通常、化粧料に配合される水；ワセリン、ス
クワラン、マイクロクリスタリンワックス等の炭化水素
類、ホホバ油、ゲイロウ、カルナウバワックス等のエス
テル類；オリーブ油、牛脂等のトリグリセライド類；セ
タノール、オレイルアルコール、ステアリルアルコール
等の高級アルコール類；ステアリン酸、オレイン酸等の
高級脂肪酸類；グリセリン、プロピレングリコール、
１，３−ブタンジオール等の多価アルコール類；エタノ
ール、プロパノール等の低級アルコール類；ジメチルポ
リシロキサン、ジメチルポリシロキサン環状４量体等の
シリコーン；脂肪酸モノグリセライド、ポオキシエチレ
ン硬化ヒマシ油等のノニオン界面活性剤；ラウリル硫酸
ナトリウム、アルキルスルホコハク酸エステル等のアニ
オン界面活性剤；４級アルキルアミン塩等のカチオン界
面活性剤；アルキルベタイン等の両性界面活性剤；アラ
ビアゴム、カルボキシビニルポリマー等の増粘剤；パラ
ベン、グルコン酸クロルヘキシジン等の防腐剤；タル
ク、シリカゲル、酸化チタン等の粉体類；トコフェロー
ル、ブチルヒドロキシトルエン等の抗酸化剤；パラアミ
ノ安息香酸誘導体、ベンゾフェノン誘導体等の紫外線吸
収剤；ポリエチレングリコール、ヒアルロン酸等の保湿
剤；グリチルリチン酸ジカリウム等の抗炎症剤；クエン
酸塩、酢酸塩等のｐＨ調整剤；キレート剤；香料；色
素；胎盤抽出物、朝鮮人参エキス、ステロール配糖体等
の各種目的に応じた薬効成分などが挙げられる。The components to be added to the cosmetic of the present invention in addition to the above-mentioned polysaccharide and the water-insoluble polymer powder having a carbonyl group include water usually added to the cosmetic; petrolatum, squalane, microcrystalline wax and the like. Esters such as hydrocarbons, jojoba oil, gay wax and carnauba wax; triglycerides such as olive oil and tallow; higher alcohols such as cetanol, oleyl alcohol and stearyl alcohol; higher fatty acids such as stearic acid and oleic acid; Glycerin, propylene glycol,
Polyhydric alcohols such as 1,3-butanediol; lower alcohols such as ethanol and propanol; silicones such as dimethylpolysiloxane and dimethylpolysiloxane cyclic tetramer; nonionic interfaces such as fatty acid monoglyceride and pooxyethylene hydrogenated castor oil Activator; Anionic surfactant such as sodium lauryl sulfate and alkyl sulfosuccinate; Cationic surfactant such as quaternary alkylamine salt; Amphoteric surfactant such as alkyl betaine; Thickener such as gum arabic and carboxyvinyl polymer Preservatives such as paraben and chlorhexidine gluconate; powders such as talc, silica gel, and titanium oxide; antioxidants such as tocopherol and butylhydroxytoluene; ultraviolet absorbers such as paraaminobenzoic acid derivatives and benzophenone derivatives; polyethylene Moisturizing agents such as recall and hyaluronic acid; anti-inflammatory agents such as dipotassium glycyrrhizinate; pH adjusters such as citrate and acetate; chelating agents; fragrances; pigments; placenta extract, ginseng extract, sterol glycosides And other medicinal ingredients according to various purposes.
【００３５】（３）本発明の皮膚外用医薬品 本発明の乳化組成物が適用可能な皮膚外用医薬品として
は、乳化型の剤形が適用できる皮膚外用医薬品であれば
特に制限されるものではない。本発明の皮膚外用医薬品
においては、通常より少ない量の界面活性剤の配合であ
るいは界面活性剤を配合せずに良好な乳化物が得られる
が、これにより従来の乳化型の皮膚外用医薬品において
問題とされていた界面活性剤に由来する皮膚内貯留性の
損失、安全性の低下等を解決することができる。また、
界面活性剤を含有しない系とすれば、栓塞貼付下での安
全性が非常に大事な貼付剤等のマトリックスにも好適に
適用できる。さらに、上記化粧料と同様、使用性等の改
善もなされている。(3) External medicine for skin of the present invention The external medicine for skin to which the emulsified composition of the present invention can be applied is not particularly limited as long as it is an external medicine for skin to which an emulsified dosage form can be applied. In the external preparation for skin of the present invention, a good emulsion can be obtained by adding a surfactant in an amount smaller than usual or without adding a surfactant. Thus, it is possible to solve the problems such as the loss of the ability to be retained in the skin and the decrease in the safety derived from the surfactant. Also,
If the system does not contain a surfactant, it can be suitably applied to a matrix such as a patch or the like in which the safety under embolization is very important. Further, like the above-mentioned cosmetics, the usability has been improved.
【００３６】本発明の皮膚外用医薬品としては、例え
ば、抗ヒスタミン剤やステロイドホルモン等を配合した
痒み止め薬、殺菌剤や抗生物質を配合した化膿防止薬、
抗炎症剤を配合した抗炎症薬、抗真菌剤を配合した水虫
治療薬やタムシ治療薬などを挙げることができる。この
様に本発明の皮膚外用医薬品には、上記多糖類とカルボ
ニル基を有する水不溶性高分子粉末以外の成分として、
抗ヒスタミン剤、ステロイドホルモン、殺菌剤、抗生物
質、抗炎症剤、抗真菌剤等の各種薬効成分が適宜選択さ
れて配合される。Examples of the external preparation for skin of the present invention include antipruritic drugs containing antihistamines and steroid hormones, antisuppuration drugs containing fungicides and antibiotics, and the like.
An anti-inflammatory drug containing an anti-inflammatory agent, a drug for treating athlete's foot or a tamushi drug containing an anti-fungal agent, and the like can be given. In this way, the external medicine for skin of the present invention includes, as a component other than the water-insoluble polymer powder having a polysaccharide and a carbonyl group,
Various pharmaceutically active ingredients such as antihistamines, steroid hormones, bactericides, antibiotics, anti-inflammatory agents, and antifungal agents are appropriately selected and blended.
【００３７】また、本発明の皮膚外用医薬品は、これら
の成分の他に通常皮膚外用医薬品に適宜配合されるエイ
ゾン等の経皮吸収促進剤や、上記化粧料の配合成分とし
て詳述した、水、炭化水素類、エステル類、トリグリセ
ライド類、高級アルコール類、高級脂肪酸類、多価アル
コール類、界面活性剤、低級アルコール類、増粘剤、防
腐剤、粉体類、抗酸化剤、紫外線吸収剤、ｐＨ調整剤、
キレート剤、色素等の各種成分を用いて通常の皮膚外用
医薬品の製造方法に従って製造することができる。In addition to the above-mentioned components, the dermatological preparation of the present invention may further contain a percutaneous absorption enhancer such as azone, which is usually appropriately compounded in dermatological preparations, or water, which is described in detail as a compounding component of the above cosmetic. , Hydrocarbons, esters, triglycerides, higher alcohols, higher fatty acids, polyhydric alcohols, surfactants, lower alcohols, thickeners, preservatives, powders, antioxidants, ultraviolet absorbers , PH adjuster,
It can be produced using various components such as a chelating agent and a pigment in accordance with a usual method for producing an external medicine for skin.
【００３８】[0038]
【実施例】以下に、本発明の実施例を説明する。まず、
化粧料の実施例について説明する。なお、化粧料の実施
例に用いる配合量は全て重量部である。また、以下の実
施例にはシュードモナス・エロディアが産生するグルコ
ース、グルクロン酸及びラムノースを構成糖とする多糖
類としてジュランガムを用いたが、これらは全てメルク
社製のケルコゲルであった。Embodiments of the present invention will be described below. First,
Examples of cosmetics will be described. The amounts used in the examples of the cosmetics are all parts by weight. Further, in the following examples, juran gum was used as a polysaccharide containing glucose, glucuronic acid and rhamnose produced by Pseudomonas aerodia, and these were all Kelcogels manufactured by Merck.
【００３９】[0039]
【実施例１〜４】 クリーム 表１の処方に基づいてクリームを作製した。すなわち、
表１に示すＡ成分、Ｂ成分をそれぞれ８０℃に加熱溶解
した後、Ｂ成分にＣ成分を分散させ、次いで撹拌しなが
らこれにＡ成分を徐々に加えて乳化し、冷却してクリー
ムを得た。Examples 1-4 Creams Creams were prepared based on the formulation in Table 1. That is,
The components A and B shown in Table 1 are each heated and dissolved at 80 ° C., and then the component C is dispersed in the component B. Then, the component A is gradually added thereto while stirring to emulsify and cool to obtain a cream. Was.
【００４０】また、比較のために、実施例２のクリーム
の配合成分中、ケルコゲルを寒天に置換したクリーム
（比較例１）、ケルコゲルをゼラチンに置換したクリー
ム（比較例２）、ケルコゲルをＰＯＥ（２０）オレイル
エーテルに置換したクリーム（比較例３）、ケルコゲル
を寒天に、結晶セルロースを水にそれぞれ置換したクリ
ーム（比較例４）を、上記と同様の製造方法でそれぞれ
作製した。For comparison, creams in which the kelcogel was replaced with agar (Comparative Example 1), creams in which the kelcogel was replaced with gelatin (Comparative Example 2), and kelcogel were POE ( 20) A cream in which oleyl ether was replaced (Comparative Example 3), a cream in which Kelcogel was replaced by agar, and a crystalline cellulose in which water was replaced (Comparative Example 4) were produced by the same production method as described above.
【００４１】[0041]
【表１】 [Table 1]
【００４２】[0042]
【実施例５〜８】 クリーム 表２の処方に基づいてクリームを作製した。すなわち、
表２に示すＡ成分、Ｂ成分をそれぞれ８０℃に加熱溶解
した後、Ｂ成分にＣ成分を分散させ、次いで撹拌しなが
らこれにＡ成分を徐々に加えて乳化し、冷却してクリー
ムを得た。Examples 5 to 8 Creams Creams were prepared based on the formulations shown in Table 2. That is,
The components A and B shown in Table 2 were each heated and dissolved at 80 ° C., and then the component C was dispersed in the component B. Then, the component A was gradually added thereto while stirring to emulsify and cooled to obtain a cream. Was.
【００４３】[0043]
【表２】 [Table 2]
【００４４】＜本発明のクリームの評価＞上記各実施例
及び各比較例で得られたクリームを用いて、使用性・使
用感の試験及び化粧持ち試験を行い、本発明のクリーム
を評価した。<Evaluation of the cream of the present invention> The creams of the present invention were evaluated by using the creams obtained in each of the above Examples and Comparative Examples, by conducting a test of usability and feeling of use and a test of cosmetic durability.
【００４５】（１）使用性・使用感の試験 上記実施例１〜８及び比較例１〜４で得られたクリーム
の使用性及び使用感についての官能評価を行った。専門
パネラー４名に、各クリームを使用してもらい、これら
のクリームについて、のびの良さ、取れ易さ（以上使用
性の評価項目）、しっとり感、さっぱり感（以上使用感
の評価項目）の４項目を非常によい（５点）〜非常に悪
い（１点）の５段階で評価してもらい、４人の平均値を
そのクリームの評点とした。結果を表３に示す。(1) Test for Usability and Usability The creams obtained in Examples 1 to 8 and Comparative Examples 1 to 4 were subjected to a sensory evaluation for usability and usability. Four specialized panelists use each cream, and for these creams, 4 of good spreadability, ease of removal (evaluation items of usability), moist feeling, refreshing feeling (evaluation items of usability) The items were rated on a 5-point scale from very good (5 points) to very bad (1 point), and the average value of the four persons was used as the score of the cream. Table 3 shows the results.
【００４６】[0046]
【表３】 [Table 3]
【００４７】この結果より、実施例のクリームは、比較
例で得られた本発明の乳化組成物の多糖類を従来の有機
高分子ゲル化剤や界面活性剤に置換したクリームやさら
に水不溶性高分子粉末を含有しないクリームに比べて、
使用性、使用感に優れていることが明らかである。From the results, the creams of the examples are creams obtained by substituting the polysaccharide of the emulsified composition of the present invention obtained in the comparative example with a conventional organic polymer gelling agent or a surfactant, or have a high water insolubility. Compared to creams that do not contain molecular powder,
It is clear that the usability and the usability are excellent.
【００４８】（２）化粧持ち試験 上記実施例１〜８及び比較例１〜４で得られたクリーム
について、このクリームの上に塗布されるメークアップ
化粧料の化粧持ちに対する作用を調べた。すなわち、各
クリームを上腕部に塗り、その上に後述の比較例８と同
様にして得られたクリームファンデーションを塗布し
て、流水下、流動パラフィン塗布下での擦りに対しての
崩れ難さを専門パネラー４名に評価してもらった。評価
は、化粧持ちが非常に良いを５点とし化粧持ちが非常に
悪いを１点とした５段階評価で、４人の平均値をそのク
リームの評点とした。結果を表４に示す。(2) Long-lasting test With respect to the creams obtained in Examples 1 to 8 and Comparative Examples 1 to 4, the effect of the makeup applied on the creams for long-lasting effect was examined. That is, each cream was applied to the upper arm portion, and a cream foundation obtained in the same manner as in Comparative Example 8 described later was applied thereon, so that the cream foundation was not easily disintegrated against rubbing under flowing water and liquid paraffin. Four expert panelists evaluated it. The evaluation was performed on a 5-point scale with 5 points for very good make-up and 1 point for very poor make-up, and the average value of the four persons was used as the score of the cream. Table 4 shows the results.
【００４９】[0049]
【表４】 [Table 4]
【００５０】この結果から、界面活性剤を含有しない実
施例のクリームは、界面活性剤を含有する比較例３のク
リームに比べて化粧持ちが著しく改善されていることが
わかる。また、「のび」と「取れ易さ」が改善された実
施例のクリームでは密着性が優れるため、比較例１、
２、４で得られた本発明の乳化組成物の多糖類、水不溶
性高分子粉末等を含有しない界界面活性剤フリーのクリ
ームに比べてもより化粧持ちが向上していることもわか
る。From these results, it can be seen that the cream of the example containing no surfactant has a significantly improved cosmetic durability compared to the cream of Comparative Example 3 containing the surfactant. In addition, the creams of the examples in which “expansion” and “easiness of removal” were improved had excellent adhesiveness.
It can also be seen that the cosmetic composition of the emulsion composition of the present invention obtained in Steps 2 and 4 has a longer lasting makeup than the surfactant free cream containing no polysaccharide, water-insoluble polymer powder, or the like.
【００５１】[0051]
【実施例９〜１２】 クリームファンデーション 表５の処方に基づいてクリームファンデーションを作製
した。すなわち、表５に示すＡ成分、Ｂ成分をそれぞれ
８０℃に加熱溶解した後、Ｂ成分にＣ成分を分散させ、
次いで撹拌しながらこれにＡ成分を徐々に加えて乳化
し、冷却してクリームファンデーションを得た。なお、
表中の成分でプロテインパウダーとは、出光石油化学
（株）製の牛皮革粉末の商品名である。Examples 9 to 12 Cream Foundation A cream foundation was prepared based on the formulation shown in Table 5. That is, the components A and B shown in Table 5 were each heated and dissolved at 80 ° C., and then the component C was dispersed in the component B.
Next, the component A was gradually added to the mixture while stirring to emulsify the mixture, followed by cooling to obtain a cream foundation. In addition,
In the components in the table, protein powder is a trade name of cow leather powder manufactured by Idemitsu Petrochemical Co., Ltd.
【００５２】また、比較のために、実施例９のクリーム
ファンデーションの配合成分中、ケルコゲルを寒天に置
換したクリームファンデーション（比較例５）、ケルコ
ゲルをゼラチンに置換したクリームファンデーション
（比較例６）、ケルコゲルを寒天に、シルクパウダーを
水にそれぞれ置換したクリームファンデーション（比較
例７）を上記と同様の製造方法でそれぞれ作製した。さ
らに、表６に配合成分を示す従来の水中油ファンデーシ
ョン（比較例８）、表７に配合成分を示す従来の高内相
油中水ファンデーション（比較例９）を上記と同様の方
法で作製して実施例のクリームファンデーションと比較
した。For comparison, the cream foundation in which the kelcogel was replaced with agar (Comparative Example 5), the cream foundation in which the kelcogel was replaced with gelatin (Comparative Example 6), and Kelcogel were used in the components of the cream foundation of Example 9. Was replaced with agar, and a cream foundation (Comparative Example 7) was prepared by replacing the silk powder with water, respectively, in the same manner as described above. Further, a conventional oil-in-water foundation having the components shown in Table 6 (Comparative Example 8) and a conventional high internal phase water-in-oil foundation having the components shown in Table 7 (Comparative Example 9) were prepared in the same manner as described above. And compared with the cream foundation of Example.
【００５３】[0053]
【表５】 [Table 5]
【００５４】[0054]
【表６】 [Table 6]
【００５５】[0055]
【表７】 [Table 7]
【００５６】＜本発明のクリームファンデーションの評
価＞上記実施例９〜１２及び比較例５〜９で得られたク
リームファンデーションを用いて化粧持ちの試験を行
い、本発明のクリームファンデーションを評価した。す
なわち、各クリームファンデーションを上腕部に塗布し
て、流水下、流動パラフィン塗布下での擦りに対しての
崩れ難さを専門パネラー４名に評価してもらった。評価
は、化粧持ちが非常に良いを５点とし化粧持ちが非常に
悪いを１点とした５段階評価で、４人の平均値をそのク
リームファンデーションの評点とした。結果を表８に示
す。<Evaluation of Cream Foundation of the Present Invention> Using the cream foundations obtained in Examples 9 to 12 and Comparative Examples 5 to 9, a makeup durability test was performed to evaluate the cream foundation of the present invention. That is, each cream foundation was applied to the upper arm, and four expert panelists evaluated the difficulty of collapsing against rubbing under running water or liquid paraffin. The evaluation was performed on a 5-point scale with 5 points for very good make-up and 1 point for very poor make-up, and the average value of four persons was used as the score of the cream foundation. Table 8 shows the results.
【００５７】[0057]
【表８】 この結果から、実施例のクリームファンデーションは、
界面活性剤を含有する比較例８のクリームファンデーシ
ョンに比べて化粧持ちが著しく改善されているばかりで
なく、比較例５〜７で得られた本発明の乳化組成物の多
糖類、水不溶性高分子粉末等を含有しない界面活性剤フ
リーのクリームファンデーションや比較例９の高内相油
中水ファンデーションに比べてもより化粧持ちが向上し
ていることがわかる。[Table 8] From these results, the cream foundation of the example is
Not only the cosmetic durability is remarkably improved as compared with the cream foundation of Comparative Example 8 containing a surfactant, but also the polysaccharide and water-insoluble polymer of the emulsion composition of the present invention obtained in Comparative Examples 5 to 7 It can be seen that the makeup lasting is further improved as compared with the surfactant-free cream foundation containing no powder or the like and the high internal phase water-in-oil foundation of Comparative Example 9.
【００５８】次に、皮膚外用医薬品の実施例について説
明する。なお、以下の実施例に用いる配合量は重量％で
ある。Next, examples of skin external preparations will be described. The amounts used in the following examples are% by weight.
【００５９】[0059]
【実施例１３〜１６】 皮膚外用剤 表９の処方に基づいて皮膚外用剤を作製した。すなわ
ち、表９のＡ成分、Ｂ成分をそれぞれ８０℃に加熱溶解
した後、Ｂ成分にＣ成分を分散させ、次いで撹拌しなが
らこれにＡ成分を徐々に加えて乳化し、冷却して皮膚外
用剤を得た。Examples 13 to 16 Skin external preparations were prepared based on the formulation shown in Table 9. That is, the components A and B in Table 9 are each heated and dissolved at 80 ° C., and then the component C is dispersed in the component B. Then, the component A is gradually added to the mixture while stirring to emulsify the mixture, and then cooled to be used for external use on the skin. Agent was obtained.
【００６０】また、比較のために日本薬局方に記載の親
水軟膏と同様にして作製した親水軟にビフォナゾールを
１重量％混ぜて混練りした抗真菌皮膚外用剤（比較例１
０）を作製した。Further, for comparison, an antifungal skin external preparation prepared by mixing 1% by weight of bifonazole with hydrophilic softener prepared in the same manner as the hydrophilic ointment described in the Japanese Pharmacopoeia (Comparative Example 1)
0) was prepared.
【００６１】[0061]
【表９】 [Table 9]
【００６２】＜本発明の皮膚外用剤の評価＞上記実施例
１４で得られた抗真菌皮膚外用剤と比較例１０で得られ
た抗真菌皮膚外用剤を用いて殺菌作用についての試験を
行った。すなわち、前記各抗真菌皮膚外用剤をそれぞれ
１ｇずつ取り、このそれぞれにトリコフィトン・メンタ
グロファイトの分生子を２×１０5個ずつ植え付け、１
４日後に前記分生子の生存の様子を染色により判定し
た。<Evaluation of the external preparation for skin of the present invention> The antifungal external preparation obtained in Example 14 and the antifungal external preparation obtained in Comparative Example 10 were tested for bactericidal action. . That is, 1 g of each of the above-mentioned antifungal skin external preparations was taken, and 2 × 10 5 conidia of Trichophyton mentagrophyte were planted in each of them, and
Four days later, the state of survival of the conidia was determined by staining.
【００６３】結果は、実施例１４の抗真菌皮膚外用剤中
に生存している菌体はほとんど認められなかったが、比
較例１０の抗真菌皮膚外用剤中では菌は僅かに生存して
いた。この結果より、実施例１４の抗真菌皮膚外用剤に
おいては、比較例１０の抗真菌皮膚外用剤に比べて、抗
真菌剤であるビフォナゾールを細胞膜を通して浸潤させ
る作用に優れることがわかる。As a result, almost no cells survived in the antifungal skin preparation for external use of Example 14, but slightly survived in the antifungal skin external preparation of Comparative Example 10. . From these results, it can be seen that the antifungal skin external preparation of Example 14 is superior to the antifungal skin external preparation of Comparative Example 10 in infiltrating the antifungal agent bifonazole through the cell membrane.
【００６４】[0064]
【発明の効果】本発明の乳化組成物においては、シュー
ドモナス・エロディアが産生するグルコース、グルクロ
ン酸及びラムノースを構成糖とする多糖類と、カルボニ
ル基を有する水不溶性高分子粉末とを含有することで、
組成物に優れた使用感を付与することができるととも
に、使用性を損なうことなく、また、乳化剤形に支障を
与えることなく、組成物中の界面活性剤の含有量を減量
することが可能である。このようにして乳化組成物中の
界面活性剤の配合量を少なくすることが可能となれば、
化粧料においては界面活性剤に由来する化粧崩れや安全
性の低下などの問題を、また、皮膚外用医薬品において
は界面活性剤に由来する皮膚内貯留性の損失、安全性の
低下等の問題を、乳化組成物の使用性を低下させること
なく有効に解決することが可能となる。The emulsified composition of the present invention comprises a polysaccharide comprising glucose, glucuronic acid and rhamnose produced by Pseudomonas aerodidia and a water-insoluble polymer powder having a carbonyl group. ,
It is possible to impart an excellent feeling of use to the composition, and it is possible to reduce the content of the surfactant in the composition without impairing the usability and without affecting the emulsified dosage form. is there. If it becomes possible to reduce the amount of the surfactant in the emulsion composition in this way,
In cosmetics, there are problems such as makeup breakdown and reduced safety due to surfactants, and in external medicines for skin, problems such as loss of skin retention and reduced safety due to surfactants. It is possible to solve the problem effectively without reducing the usability of the emulsified composition.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 ＦＩ Ａ６１Ｋ 47/36 Ａ６１Ｋ 47/36 // Ｃ０８Ｂ 37/00 Ｃ０８Ｂ 37/00 Ｐ (56)参考文献 特開 昭64−40415（ＪＰ，Ａ) 特開 昭64−27634（ＪＰ，Ａ) 特開 平６−32722（ＪＰ，Ａ) 特開 平３−261707（ＪＰ，Ａ) 特開 昭62−267213（ＪＰ，Ａ) 特開 平７−300410（ＪＰ，Ａ) 特開 昭62−114905（ＪＰ，Ａ) (58)調査した分野(Int.Cl.7，ＤＢ名) A61K 9/107 A61K 47/36 A61K 7/00 A61K 7/48 ────────────────────────────────────────────────── ─── Continued on the front page (51) Int.Cl. 7 Identification code FI A61K 47/36 A61K 47/36 // C08B 37/00 C08B 37/00 P (56) References JP-A-64-40415 (JP) JP-A-64-27634 (JP, A) JP-A-6-32722 (JP, A) JP-A-3-261707 (JP, A) JP-A-62-267213 (JP, A) 7-300410 (JP, A) JP-A-62-114905 (JP, A) (58) Fields investigated (Int. Cl. 7 , DB name) A61K 9/107 A61K 47/36 A61K 7/00 A61K 7 / 48
Claims (5)
するグルコース、グルクロン酸及びラムノースを構成糖
とする多糖類と、（２）カルボニル基を有する水不溶性
高分子粉末と、を含有する化粧料用又は皮膚外用医薬品
用の乳化組成物。1. A cosmetic or cosmetic comprising (1) a polysaccharide comprising glucose, glucuronic acid and rhamnose produced by Pseudomonas aerodidia and (2) a water-insoluble polymer powder having a carbonyl group. Skin external medicine
Emulsified composition for use .
−β−D−グルコース（１→４）−β−D−グルクロン酸
（１→４）−β−D−グルコース（１→４）−α−L−ラ
ムノース（１→］を繰り返し単位とする多糖類である請
求項１記載の乳化組成物。 【化１】 （但し、ｎは整数を表す。）2. The polysaccharide represented by the general formula (I) [→ 3]
-Β-D-glucose (1 → 4) -β-D-glucuronic acid (1 → 4) -β-D-glucose (1 → 4) -α-L-rhamnose (1 →) The emulsion composition according to claim 1, which is a saccharide. (However, n represents an integer.)
が、水不溶性多糖類粉末、水不溶性タンパク質粉末、ポ
リアミド粉末、アクリル樹脂粉末から選ばれる１種又は
２種以上である請求項１又は２記載の乳化組成物。3. The water-insoluble polymer powder having a carbonyl group is one or more selected from water-insoluble polysaccharide powder, water-insoluble protein powder, polyamide powder, and acrylic resin powder. Emulsified composition.
が、セルロース粉末、シルクパウダー、牛皮革粉末から
選ばれる１種又は２種以上である請求項３記載の乳化組
成物。4. The emulsion composition according to claim 3, wherein the water-insoluble polymer powder having a carbonyl group is one or more selected from cellulose powder, silk powder, and cow leather powder.
１〜５重量％であり、カルボニル基を有する水不溶性高
分子粉末の含有量が組成物全量に対して０．１〜２０重
量％である請求項１〜４の何れか一項に記載の乳化組成
物。5. The composition according to claim 1, wherein the content of polysaccharide is 0.1 to the total amount of the composition.
The emulsion according to any one of claims 1 to 4, wherein the content of the water-insoluble polymer powder having a carbonyl group is 0.1 to 20% by weight based on the total amount of the composition. Composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP06656296A JP3351954B2 (en) | 1996-03-22 | 1996-03-22 | Emulsion composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP06656296A JP3351954B2 (en) | 1996-03-22 | 1996-03-22 | Emulsion composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH09255559A JPH09255559A (en) | 1997-09-30 |
| JP3351954B2 true JP3351954B2 (en) | 2002-12-03 |
Family
ID=13319517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP06656296A Expired - Fee Related JP3351954B2 (en) | 1996-03-22 | 1996-03-22 | Emulsion composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3351954B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102211409B1 (en) * | 2019-07-26 | 2021-02-03 | 주식회사 코리아나화장품 | Cosmetic composition for preventing damage of skin by heat |
-
1996
- 1996-03-22 JP JP06656296A patent/JP3351954B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH09255559A (en) | 1997-09-30 |
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