JPH09188606A - Hair tonic cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a hair tonic cosmetic stable over time by its pH adjustment. SOLUTION: This hair tonic cosmetic is obtained by removing pilocarpine from the extract from the leaves of pilocarpus, a kind of rutaceous plant (e.g. pilocarpus jaborandi, pilocarpus microphyllus), and adjusting the pH level of the resultant extract to >=2 but <7. The amount of the active ingredient of this cosmetic to be formulated is pref. 0.005-10wt.% (in terms of dry weight) based on the whole amount of the cosmetic. The pH adjuster to be used is e.g. an alkaline substance such as an alkali (alkaline earth) metal hydroxide. The extraction is preferably carried out at 10-100 deg.C for one hour to 10 days by use of 5-100 pts.wt. of a solvent (e.g. water, ethanol) per pt.wt. of the dry leaves. Besides, it is preferable that this cosmetic be formulated with a germicide such as benzoic or salicylic acid because of possible decline in its antimicrobial potency depending on its pH level.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a hair nourishing cosmetic which is stable over time.

[0002]

2. Description of the Related Art Plants of the genus Pilocarpus of the citrus family, such as Pilocarpus jabo
randi) is an evergreen shrub that is mostly found in Central and South America, especially Brazil, and its leaves are mainly used as a raw material for the production of pilocarpine (perspirants, miotics). JP-A-4-35
Japanese Patent No. 2711 describes a hair nourishing cosmetic composition containing, as an active ingredient, a component other than pilocarpine derived from an extract of a leaf of a plant of the genus Pilocarpus, and a method for producing the same. However, as a result of the studies by the present inventors, it was found that when the hair nourishing cosmetic composition described in this publication is produced, a precipitate called “olit” is generated, and the intended hair nourishing effect may be weakened.

[0003]

The present invention contains a component other than pilocarpine derived from a leaf extract of a plant belonging to the citrus family Pilocarpus, as an active ingredient, and does not cause sediment. It is intended to provide a stable hair nourishing cosmetic.

[0004]

[Means for Solving the Problems] In order to achieve the above object, the inventors of the present invention have conducted extensive studies, and as a result, have confirmed that the components other than pilocarpine derived from the leaf extract of the plant of the citrus family Pilocarpus are effective ingredients. It has been found that the above problems can be solved by setting the pH of the hair nourishing cosmetics contained as 2 to less than 7 and the present invention has been completed. That is,
The present invention includes the following inventions.

(1) Rutaceae Pilocarpus
A hair nourishing cosmetic containing as an active ingredient a component other than pilocarpine derived from a leaf extract of a genus plant and having a pH of 2 or more and less than 7. (2) The hair nourishing cosmetic according to (1), which does not substantially contain pilocarpine. (3) The hair nourishing cosmetic according to (1) or (2) above, which contains a bactericide. (4) A method for producing a hair nourishing cosmetic, which comprises removing pilocarpine from an extract of a leaf of a plant belonging to the genus Pilocarpus of the citrus family and adjusting the pH to 2 or more and less than 7. (5) The above (4), which contains a bactericide.
Production method described in 1.

Pilocarpus used in the present invention
The genus plant is not particularly limited and includes, for example, Pilocarpus jaborandi, Pilocarpus
Microfilus (Pilocarpus microphyllus), Pilocarp
us pennatifolius (Pilocarpus selloanus), Pilocarpus
racemosus, preferably Pilocarpus Jaborangi
ocarpus jaborandi), Pilocarpus microfilus (P
ilocarpus microphyllus). Plant leaves
Dry leaves or fresh leaves may be used.

The components other than pilocarpine derived from the leaf extract of the plant of the genus Pilocarpus belonging to the citrus family, which is the active ingredient of the hair nourishing cosmetic composition of the present invention (hereinafter simply referred to as "active ingredient"), are substantially contained. It is preferably free of pilocarpine. Here, the phrase "substantially free of pilocarpine" means that the treatment for removing pilocarpine has been performed, and it is not necessary that pilocarpine is completely removed. The active ingredient is Pilocalps (Piloc
It can be obtained from the leaf extract of the genus arpus) by the following treatment.

As the extraction solvent, it is preferable to use one or more solvents such as water, ethanol, acetone, ethyl ether, propylene glycol, ethylene glycol, glycerin, ethyl acetate and butyl acetate. The extraction operation is not particularly limited, but for example, 5 to 100 parts by weight of the solvent is preferable to 1 part by weight of dried leaves. The temperature and time at the time of extraction at that time are preferably 10 to 100 ° C. and 1 hour to 10 days. The obtained extract may be used in the next step as it is, or may be subjected to processing such as concentration, drying, and purification, if necessary.

Since the pilocarpus leaf extract contains pilocarpine, it is preferable to use a pilocarpine-treated extract. As a means for removing pilocarpine from the extract, it is preferable to utilize column chromatography using an ion exchange resin. As the ion exchange resin, Diaion (manufactured by Mitsubishi Chemical Co., Ltd.), Mcl gel (manufactured by Mitsubishi Chemical Co., Ltd.) and the like are used, and as the eluent, for example, water, ethanol, acetone, 1,3-butylene glycol and the like can be used. .

The content of the active ingredient in the hair nourishing cosmetic of the present invention is usually 0.001 to 50% by weight, preferably 0.005 to 10% by dry weight, based on the total amount of the hair nourishing cosmetic.
% By weight. If the amount is less than 0.001% by weight, no hair-growth effect is obtained, and if it exceeds 50% by weight, an increase in hair-growth effect cannot be expected, which is uneconomical. As the above-mentioned extract which is an active ingredient, an extract, a pilocarpine-removed extract, a concentrate thereof to a solid content of about 16%, or a dry matter is used.

Further, in adjusting the pH, it is necessary to appropriately select the following components and set them to 2 or more and less than 7. As the pH adjuster, an alkaline substance such as a hydroxide of an alkali metal or an alkaline earth metal, or an acidic substance such as a hydrohalic acid such as hydrochloric acid can be used. When the pH is 7 or more, the formulation is liable to cause sediment, which is not preferable. If it is less than 2, it is not preferable in terms of safety.

As described above, it is possible to prevent the occurrence of sediment by adjusting the pH, but depending on the pH value, the antibacterial activity may be remarkably reduced. Therefore, the hair nourishing cosmetic composition of the present invention is sterilized. It is preferable to add an agent. Examples of the bactericide include benzoic acid, salicylic acid, sorbic acid, paraoxybenzoic acid ester, dehydroacetic acid and the like, but paraoxybenzoic acid ester and salicylic acid are particularly preferable.

[0013]

Preferred embodiments of the present invention will be described below. Pilocarpu
s jaborandi), Pilocarps Microfils
The dried leaves such as pus microphyllus) are extracted with 5 to 100 parts by weight of extraction solvent such as water based on 1 part by weight of the dried leaves. The temperature and time at the time of extraction at that time are 10 to 100.
The temperature is set to 1 ° C. for 1 hour to 10 days.

If necessary, the obtained extract is subjected to processing such as concentration, drying and purification, and then pilocarpine is removed by column chromatography using an ion exchange resin. As the ion exchange resin, Diaion (manufactured by Mitsubishi Chemical Co., Ltd.), Mcl gel (manufactured by Mitsubishi Chemical Co., Ltd.) or the like is used, and as the eluent, for example, water, ethanol, acetone, 1,3-
Butylene glycol or the like is used.

The active ingredient obtained as described above is converted into a dry weight of 0.005 to 1 with respect to the total amount of the hair nourishing cosmetic.
0% by weight, and an appropriate amount of a disinfectant such as paraoxybenzoic acid ester and salicylic acid are mixed, and the pH is adjusted by using an alkaline substance such as an alkali metal or alkaline earth metal hydroxide.
Is adjusted to 2 or more and less than 7, preferably 4.0 to 6.9, more preferably 6.0 to 6.8 to obtain the hair nourishing cosmetic of the present invention. Furthermore, in the hair nourishing cosmetic of the present invention, in addition to the above components, if necessary, components such as an oily component, a surfactant, vitamins, a pearling agent, a solvent, a pigment, and a fragrance may be added. it can.

[0016]

EXAMPLES The present invention will now be described with reference to examples and preparation examples, but the present invention is not limited thereto. Preparation Example 1 Preparation of Pilocarpus Leaf Extract 3 kg of dried leaves of Pilocarpus jaborandi and 60 L of purified water were heated and gently refluxed for 4 hours, and then filtered to extract about 50 kg. Liquid (A) was obtained. The solid content at that time was 1 kg.

Diaion SK-1B (manufactured by Mitsubishi Chemical Corporation)
After passing the same amount of 5% hydrochloric acid as the resin through a chromatographic column having a diameter of 5.5 cm filled with 10 kg, the eluate was made almost neutral by introducing purified water, and then the extract (A) was added. Conduct the extraction and extract (B) 68 using 20 kg of water as the eluent.
kg. As a mixing means of the extract (A) and the extract (B) thus obtained, the extract is directly or under reduced pressure concentrated if necessary, and the solid content concentration is 16%.
It is only necessary to add a concentrated product or a dried product. (Examples 1 to 3)

[0018]

[Table 1]

Potassium hydroxide was further added to the above formulation to adjust the pH to 6.0 to obtain the hair nourishing cosmetic composition of the present invention. (Example 4)

[0020]

[Table 2]

[0021] Potassium hydroxide was added to the above formulations and the pH was adjusted to the values shown in Table 3 below. The changes with time and safety of each formulation were evaluated. The results are shown in Table 3.

[0022]

[Table 3]

The evaluation method and standard of the change with time and the safety are shown below. (Change with time) Method: The state of the preparation after one month was visually confirmed. ◎: No problem at all ○: No problem ×: Stability occurred and stability was not possible (safety) Method: A patch test was carried out on 30 healthy subjects to judge the overall evaluation. ◎: No reaction (negative) ○: No reaction or slight erythema (false positive)
X: When clear erythema (positive) was observed

Example 5 Hair Growth Tonic Extract (B) Dry Solid 2.0 wt% Ethanol 60.0 wt% Polyoxyethylene (50EO) Hydrogenated Castor Oil 0.5 wt% Propylene Glycol 2.0 wt% Fragrance 0.5% by weight Dye 0.5% by weight Purified water Remainder Potassium hydroxide was added so that the pH would be 6.0.

Example 6 Shampoo Extract (B) Concentrate (solid content 16%) 3.5% by weight Sodium alkyl ether sulfate 16.0% by weight Lauric acid diethanolamide 4.0% by weight Propylene glycol 2.0 % By weight Fragrance 1.0% by weight Dye 1.0% by weight Purified water Remainder Sodium hydroxide was added so that the pH would be 6.2.

(Example 7) Hair growth tonic extract (B) dry matter 2.0% by weight methyl paraoxybenzoate 0.1% by weight ethanol 60.0% by weight polyoxyethylene (50EO) hydrogenated castor oil 0.5 % By weight Propylene glycol 2.0% by weight Perfume 0.5% by weight Dye Trace amount Purified water Remainder Potassium hydroxide was blended so that pH was 6.0.

(Example 8) Hair Cream Extract (B) Concentrate (solid content 16%) 2.0% by weight Butyl paraoxybenzoate 0.1% by weight Beeswax 3.0% by weight Liquid paraffin 50.0% by weight % Stearic acid 3.0% by weight Polyglycerin fatty acid ester 2.5% by weight Sorbitan fatty acid ester 1.5% by weight Perfume 0.5% by weight Dye Trace amount Purified water Remainder Potassium hydroxide is added to make the pH 6.3. did.

[0028]

INDUSTRIAL APPLICABILITY According to the present invention, citrus family pilocarpus
(Pilocarpus) It is possible to provide a hair nourishing cosmetic which contains components other than pilocarpine derived from a leaf extract of a genus plant as an active ingredient and is stable over time.

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Shingo Tanino 392 Tsukiji, Fujieda-shi, Shizuoka Pref.

Claims (5)

[Claims] 1. A hair nourishing cosmetic composition containing as an active ingredient a component other than pilocarpine derived from an extract of a leaf of the genus Pilocarpus of the citrus family, and having a pH of 2 or more and less than 7. 2. The hair nourishing cosmetic according to claim 1, which does not substantially contain pilocarpine. 3. The hair nourishing cosmetic according to claim 1, which contains a bactericide. 4. Pilocarpine is removed from the leaf extract of the plant of the citrus family Pilocarpus and the pH is adjusted to 2
A method for producing a hair nourishing cosmetic, which comprises adjusting the amount to 7 or less. 5. The method according to claim 4, wherein a bactericide is contained.