JPH09132531A - Composition for additive to liquid food and liquid food - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for an additive to a liquid food and the liquid food capable of absorbing metallic elements tending to be most insufficient in transintestinal nutrition without any fear of adverse effects. SOLUTION: This composition for an additive to a liquid food contains an extract of an oyster flesh as an active ingredient. The composition for the additive to the liquid food is preferably prepared as a pasty form and regulated to pH 4-5.5. When the composition is in the pasty form, the solid content is preferably regulated to 40-55wt./wt.%. The liquid food contains the composition blended therein.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention has been adjusted so that it can be added and mixed as it is to liquid food in order to supplement and ingest essential trace elements essential to human life activities such as Zn and Cu. The present invention relates to a composition for adding liquid food. The present invention also relates to a liquid food containing the above composition.

[0002]

2. Description of the Related Art There are 45 kinds of elements whose existence has been confirmed in the living body, and of them, 27 kinds are essential elements essential for life activity. Of these essential elements, those whose daily required intake is less than Fe or those whose daily required intake is 100 mg or less are called essential trace elements, and human essential trace elements are Cu, Zn, M.
It is said to be n, I, Co, Cr, Se, Mo.
Such essential trace elements mainly act in the living body as a metal enzyme or a metal-requiring enzyme, and play an important role in the activity expression of the enzyme.If they are deficient, various diseases occur as deficiency. Let

As the deficiency of trace elements, Zn deficiency, which has a relatively large average daily intake, is the most common, followed by Cu deficiency. By the way, the average daily intake of Zn is 15 mg for adult males and 12 mg for adult females.
(However, 19 mg in the lactation period), and Cu is said to be 1.5 to 3 mg in adults.

[0004] For example, Zn is involved in the activity expression of more than 200 metalloenzymes involved in protein and nucleic acid metabolism, and human deficiency is characterized by dwarfism, secondary hypogonadism and splenomegaly. , Autosomal recessive inheritance, such as intractable diarrhea and intestinal acrodermatitis with rash as the main features are known. In addition to the skin rash, the clinical symptoms include stomatitis, glossitis, hair loss, nail changes, diarrhea, and other symptoms.

Further, for example, Cu is involved in the hematopoietic function together with Fe, and is involved in the metabolism of connective tissues such as elastin and collagen and the function of electron transfer system. Known neutropenia and bone changes (decrease in bone age, irregular metaphysis, and thinning of cortex) are known.

When the food is normally orally taken, the above-mentioned essential trace elements are taken up by the elements contained in the food, so that the above-mentioned deficiency is rarely caused. Absent. However, in the case of so-called enteral nutrition in which an artificially adjusted liquid diet is ingested by a tube, those liquid diets lack sufficient essential trace elements that can be absorbed harmlessly from the digestive tract. Often becomes. For example, Zn deficiency occurs within a few months after the start of enteral nutrition by a liquid diet currently on the market, and it is said that symptoms such as stomatitis, glossitis, hair loss, nail changes and diarrhea appear in addition to skin rash.

[0007]

For example, in the case of TPN (so-called parenteral nutrition in which a drug product containing a chemical substance is ingested intravenously), trace element deficiency often occurs as in the case of enteral nutrition. Trace element supplements packaged in ampoules have been developed and marketed in TPN, and trace element deficiencies can be treated and prevented by intravenously administering the trace element preparations together with parenteral nutrition agents. However, as for enteral nutrition, supplements of essential trace elements have not been developed or provided yet. Therefore, even in the case of enteral nutrition, it is inconvenient because the trace element supplement as described above must be administered intravenously, and furthermore, the trace element supplement as described above is chemically prepared. ,
It is hard to say that there are no side effects.

The object of the present invention is to avoid side effects,
It is to provide a composition for liquid food addition capable of absorbing the metal element, which is most deficient in enteral nutrition, from the digestive tract. Another object of the present invention is to provide a liquid food containing a main metal element that can be absorbed from the digestive tract without fear of side effects.

[0009]

According to the invention of claim 1, in order to solve the above-mentioned problems, a composition for liquid food addition containing an extract of oyster meat as an active ingredient is provided. Claim 2
According to the invention, the liquid food additive composition of claim 1 is in the form of a paste. In the invention of claim 3, the composition for adding liquid food of claim 2 is adjusted to pH 4 to 5.5. The invention of claim 4 has a solid content of 40 to 55 w / w in the composition for adding liquid food of claim 2 or 3.
It is adjusted to%. The invention of claim 5 is characterized in that the oyster meat extract is extracted by enzymatic treatment after hot water treatment or before hot water treatment. According to the invention of claim 6, in order to solve the above-mentioned problems, a liquid food containing the composition according to any one of claims 1 to 5 is provided.

[0010]

BEST MODE FOR CARRYING OUT THE INVENTION The oyster meat extract necessary for carrying out the present invention is an oyster peeled as it is or dried and crushed, an extract obtained by hot water extraction, an extract by enzymatic decomposition, An extract obtained by a hydrous lower alcohol and other known extraction methods can be used, but an extract by enzymatic decomposition, particularly an extract obtained by combining hot water extraction and enzymatic decomposition is preferable. Is preferred.
This is because the oyster meat extract obtained by enzymatic decomposition or hot water extraction and enzymatic decomposition has a higher content of elements such as Zn and Cu.

The hot water extract of oyster meat is obtained by extracting the crushed oyster meat in hot water at 60 to 100 ° C., preferably 70 to 95 ° C. for about 1 to 3 hours for separation, separation of oil and water, and filtration. It can be obtained by going through the steps of, vacuum concentration, and heat sterilization. The hot water extract can be used as it is as an active ingredient of the composition of the present invention, but a precipitate obtained by subjecting it to an alcohol fraction with, for example, ethanol may be used as the active ingredient.

The enzyme-decomposed extract of oyster meat is obtained by crushing the oyster peeled product with alkaline protease, neutral protease by koji mold or other proteolytic enzyme to give an amount of 30-6.
It is obtained by treating at 0 ° C. for about 5 to 7 hours for extraction, and performing each step of separation, oil-water separation, filtration, concentration under reduced pressure, and heat sterilization. Further, an extract obtained by performing the above-mentioned hot water extraction after the enzyme treatment can be used as the composition of the present invention.

The extract obtained as described above may be adjusted to powder or granules by subjecting it to heat sterilization and spray drying, but it may be in the form of paste or powder or granules. Is preferably suspended in a drinkable solution to prepare a paste. Such a paste-like extract or an extract prepared in a paste-like form is easily mixed when it is directly mixed with the liquid food, and the administration of the liquid food via the tube can be facilitated. Easy to mix in liquid food,
In addition, in order to adjust the components of the additive composition to a paste form so as not to dilute, the solid content is preferably adjusted to 40 to 55 w / w%.

When the oyster meat extract is adjusted to a paste having a solid content ratio as described above with water (distilled water), small cluster water containing calcium ions, potassium ions, sodium ions or the like, or a predetermined amount It is preferable to use small cluster water treated with a strong magnetic field or to adjust with mineral water or the like. Ordinary water consists of more than 20 molecular groups,
This is because the small cluster water has a smaller molecular population than ordinary water, and the components in the aqueous solution of the small cluster water and the components coexisting with the small cluster water have a high absorption rate to the living body and a much higher absorption rate.

When the oyster meat extract is in the form of a paste, it expands during heat sterilization to generate a gas, so it is preferable to degas in parallel with or after heat sterilization. In addition, since the basto-like extract may rot with time if it is hermetically packaged as it is, it is preferable to adjust the pH to about 4 to 5.5 with a pH adjusting agent in order to prevent rot.

The oyster meat extract as described above is used as it is,
Alternatively, the composition of the present invention can be prepared by adjusting the pH and solid component ratio as described above, but the composition of the present invention can also be prepared by adding other active ingredients. .

The oyster meat extract as described above has a slight difference depending on the extraction method, but 41 to 100 g of oyster meat extract are present.
It contains about 47 mg of Zn and about 2 mg of Cu. Therefore, by administering the composition of the present invention containing an oyster meat extract as an active ingredient, or by adding and mixing the composition with liquid food and eating with the liquid food, the above-mentioned problems caused by the deficiency of Zn or Cu are caused. Such deficiencies can be prevented and various diseases caused by them can be cured. Further, since the oyster meat extract is an extract of natural food, there is no fear of side effects and it is well absorbed by the digestive tract.

The liquid food additive composition according to the present invention is hermetically packaged in order to supply it to the market. The packaging means for packaging the composition is prepared by mixing and dispersing antibacterial particles containing an antibacterial metal. It is preferable to use a packaging bag or a packaging container manufactured from the resin. These packaging bags or packaging containers, if the antibacterial particles are dispersed on the inner surface thereof, when the composition is packaged, by contacting the inner surface of the packaging means with the composition,
Since it is always sterilized, it can be used in a very hygienic state.

As described above, the composition is usually added to and mixed with the liquid food and eaten together with the liquid food, but it is also possible to supply the liquid food containing the composition in advance to the market. As the liquid food containing the composition, a general or special liquid food for patients currently used in the market is used, but it is a liquid food containing milk protein or skim milk powder as a main ingredient. Is preferred.

Example Frozen oyster peeled meat was crushed, and this was crushed in hot water at 90 ° C. for 1 hour.
After holding for about an hour to extract with hot water, the enzyme was treated in a three-step process for about 6 hours in a state of being cooled to 40 to 50 ° C., filtered with a drum filter or the like, and further centrifuged. What was centrifuged as described above was filtered more precisely with a filter press or the like, the extract was adjusted to about pH 5 with a pH adjuster, and then concentrated under reduced pressure by a conventional method to obtain an oyster meat extract. After concentration, degassing was performed while heating and sterilizing (eg, 95 ° C. for about 2 hours), and then the solid content was adjusted to 50 w / w%, which was used as a liquid food addition composition.

The content of components in 100 g of the above composition is shown in Table 1. Table-1 (Component) (Content) (Component) (Content) Zinc 46.3 mg Copper 2.1 mg Iron 9.6 mg Lead 9.6 mg Taurine 1800.0 mg Glycogen 17000.0 mg Sodium 585.4 mg Potassium 2282.7 mg Calcium 64.4 mg Phosphorus 229.4 mg Magnesium 84.6 mg Cadmium 0.07 ppm Heavy metals 11 to 16.5 ppm Arsenic 8.25 ppm or less Manganese 1.6 mg

30 g of the above composition was mixed with skim milk powder, casein Na, vegetable oil, dextrin, cellulose, emulsifier, stabilizer (carrageenan), magnesium sulfate, pH adjuster,
It was mixed with 1000 ml of liquid food (high nutrition liquid food MA-7 manufactured by Morinaga Milk Industry Co., Ltd.) containing flavors and the like as main raw materials.
This liquid diet was used for a patient with symptoms specific to Zn deficiency (the daily dose is 1000 ml of liquid diet and 30 g of the above composition).
The results were as in Clinical Test Example-1. In addition, 70 g of the above composition was added to dextrin, milk protein, vegetable oil, sucrose, cellulose, emulsifier, stabilizer (carrageenan), pH.
Liquid foods that use regulators, magnesium chloride, flavors, etc. as the main raw materials (high nutrition liquid food MA- manufactured by Morinaga Milk Industry Co., Ltd.
8) 1000 ml was mixed, and this was used for a patient having a symptom peculiar to Cu deficiency (the daily dose is 1000 ml of liquid food and 70 g of the composition). The results were as in Clinical Test Example-2. The standard composition of 100 ml of the liquid food MA-7 is shown in Table 2 and 100 ml of the liquid food MA-8.
The standard composition of each is as shown in Table-3,
Their energy is 100 calories per 100 ml.

Table-2 (Component) (Content) (Component) (Content) Protein 3200.0 mg Fat 3200.0 mg Carbohydrate 14600.0 mg Plant fiber 400.0 mg Ash 600.0 mg Water 85000.0 mg Vitamin A 150.0 IU Vitamin B ₁ 0.08 mg Vitamin B ₂ 0.08 mg Vitamin B ₆ 0.16 mg Vitamin B ₁₂ 0.24 μg Vitamin C 4.0 mg Vitamin D 8.0 IU Vitamin E 1.0 IU Niacin 1.5 mg Folic acid 32.0 μg Pantothenic acid 0.8 mg Sodium 61.0 mg Potassium 130.0 mg Chlorine 80.0 mg Calcium 90.0 mg Phosphorus 75.0 mg Magnesium 12.0 mg Iron 0.8 mg Copper 10.0 μg Zinc 0.3 mg Manganese 6.0 μg (Margins below this page)

Table-3 (Component) (Content) (Component) (Content) Protein 4000.0 mg Fat 3000.0 mg Sugar 14300.0 mg Plant fiber 400.0 mg Ash 500.0 mg Water 84800.0 mg Vitamin A 220.0 IU Vitamin B ₁ 0.10 mg Vitamin B ₂ 0.11 mg Vitamin B ₆ 0.15 mg Vitamin B ₁₂ 0.20 μg Vitamin C 4.0 mg Vitamin D 14.0 IU Vitamin E 1.0 IU Vitamin K 5.0 μg Niacin 1.5 mg Folic acid 30.0 μg Pantothenic acid 0.5 mg Sodium 75.0 mg Potassium 95.0 mg Chlorine 110.0 mg Calcium 60.0 mg Phosphorus 60.0 mg Magnesium 20.0 mg Iron 0.8 mg Copper 10.0 μg Zinc 0.1 mg Manganese 5.0 μg

Clinical Test Example-1 (Patient) (Age) (Gender) (Zn deficiency symptom) (Days until recovery after initiation) A 48 Male skin rash, stomatitis 22 B 58 Male skin rash, stomatitis 21 C 66 Male skin rash, stomatitis , Diarrhea 30 D 68 Female eruption, stomatitis, glossitis 25 E 75 Female eruption, stomatitis 28 F 79 Female eruption 28 (white space below this page)

Clinical Test Example-2 (Patient) (Age) (Gender) (Cu deficiency symptom) (Days until recovery after initiation) A 67 Male Anemia not responding to Fe administration 19 B 77 Woman Id 23

When only the liquid food additive composition of the above-mentioned Example was used in the clinical test using the same daily dose as in the above-mentioned Test Example, almost the same results were obtained.

[0028]

According to the composition of the invention of claim 1, since the oyster meat extract is the active ingredient, Zn and Cu contained in the composition are contained.
It is possible to cure the deficiency of Zn and Cu, which is easily absorbed in the case of so-called enteral nutrition in which liquid is absorbed through the digestive tract and eats liquid food, and to prevent those deficiencies. Further, since the oyster meat extract is the active ingredient, there is no risk of side effects.

According to the composition of the second aspect of the present invention, since it is a paste, it can be easily mixed with the liquid food when added to the liquid food.

According to the composition of the invention of claim 3, pH 4
It's adjusted to ~ 5.5, so it's hard to rot. According to the composition of the invention of claim 4, since the solid content is 40 to 55 w / w%, the oyster meat extract which is the active ingredient can be mixed well with the liquid food to the extent that it does not become diluted. .

According to the invention of claim 5, the content of Zn or Cu in the oyster meat extract becomes higher.

According to the liquid food of the invention of claim 6, since the composition for liquid food addition according to any one of claims 1 to 5 is blended, deficiency of Zn or Cu can be cured. At the same time, those deficiencies can be prevented. Further, since the composition to be blended contains an extract of oyster meat as an active ingredient, there is no risk of side effects.

Claims (6)

[Claims] 1. A composition for adding liquid foods, which comprises an extract of oyster meat as an active ingredient. 2. The composition for adding liquid food according to claim 1, which is in a paste form. 3. The liquid food additive composition according to claim 2, which is adjusted to have a pH of 4 to 5.5. 4. The liquid food additive composition according to claim 2, wherein the solid content is 40 to 55 w / w%. 5. The composition for adding liquid food according to any one of claims 1 to 4, wherein the oyster meat extract is extracted by enzymatic treatment after hot water treatment or before hot water treatment. Stuff. 6. A liquid food containing the composition for adding liquid food according to any one of claims 1 to 5.