JPH08501550A - ヒトの認識障害の治療に有用な３，３’−ジ置換−１，３−ジヒドロ−２Ｈ−ピロロ〔２，３−ｂ〕ヘテロ環式−２−オン - Google Patents

ヒトの認識障害の治療に有用な３，３’−ジ置換−１，３−ジヒドロ−２Ｈ−ピロロ〔２，３−ｂ〕ヘテロ環式−２−オン

Info

Publication number
JPH08501550A
JPH08501550A JP6508194A JP50819494A JPH08501550A JP H08501550 A JPH08501550 A JP H08501550A JP 6508194 A JP6508194 A JP 6508194A JP 50819494 A JP50819494 A JP 50819494A JP H08501550 A JPH08501550 A JP H08501550A
Authority
JP
Japan
Prior art keywords
alkyl
carbon atoms
phenyl
pyridinylmethyl
pyrrolo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6508194A
Other languages
English (en)
Japanese (ja)
Inventor
ウイルカーソン，ウエンドル・ウイルキー
Original Assignee
ザ・デュポン・メルク・ファーマシュウティカル・カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ・デュポン・メルク・ファーマシュウティカル・カンパニー filed Critical ザ・デュポン・メルク・ファーマシュウティカル・カンパニー
Publication of JPH08501550A publication Critical patent/JPH08501550A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP6508194A 1992-09-18 1993-09-16 ヒトの認識障害の治療に有用な３，３’−ジ置換−１，３−ジヒドロ−２Ｈ−ピロロ〔２，３−ｂ〕ヘテロ環式−２−オン Pending JPH08501550A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/947,152 1992-09-18
US07/947,152 US5278162A (en) 1992-09-18 1992-09-18 3,3'-disubstituted-1,3-dihydro-2H-pyrrolo[2,3-b]heterocyclic-2-one useful in the treatment of cognitive disorders of man
PCT/US1993/008563 WO1994006793A1 (en) 1992-09-18 1993-09-16 3,3'-DISUBSTITUTED-1,3-DIHYDRO-2H-PYRROLO[2,3-b]HETEROCYCLIC-2-ONE USEFUL IN THE TREATMENT OF COGNITIVE DISORDERS OF MAN

Publications (1)

Publication Number Publication Date
JPH08501550A true JPH08501550A (ja) 1996-02-20

Family

ID=25485622

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6508194A Pending JPH08501550A (ja) 1992-09-18 1993-09-16 ヒトの認識障害の治療に有用な３，３’−ジ置換−１，３−ジヒドロ−２Ｈ−ピロロ〔２，３−ｂ〕ヘテロ環式−２−オン

Country Status (10)

Country Link
US (1) US5278162A (enExample)
EP (1) EP0660833A1 (enExample)
JP (1) JPH08501550A (enExample)
CN (1) CN1094406A (enExample)
AU (1) AU4856893A (enExample)
CA (1) CA2144636A1 (enExample)
IL (1) IL107003A0 (enExample)
TW (1) TW248560B (enExample)
WO (1) WO1994006793A1 (enExample)
ZA (1) ZA936872B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5296478A (en) * 1992-10-07 1994-03-22 The Dupont Merck Pharmaceutical Co. 1-substituted oxindoles as cognition enhancers
WO1995029909A1 (en) 1994-04-29 1995-11-09 Pfizer Inc. Novel acyclic and cyclic amides as neurotransmitter release enhancers
US5744476A (en) * 1994-06-27 1998-04-28 Interneuron Pharmaceuticals, Inc. Dopamine D1 agonists for the treatment of dementia
AR053710A1 (es) * 2005-04-11 2007-05-16 Xenon Pharmaceuticals Inc Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
MY144968A (en) * 2005-04-11 2011-11-30 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
AR053713A1 (es) * 2005-04-20 2007-05-16 Xenon Pharmaceuticals Inc Compuestos heterociclicos y sus usos como agentes terapeuticos
MX2009003874A (es) * 2006-10-12 2009-04-22 Xenon Pharmaceuticals Inc Derivados de espiro-oxindol triciclicos y sus usos como agentes terapeuticos.
CL2007002950A1 (es) * 2006-10-12 2008-02-01 Xenon Pharmaceuticals Inc Uso de compuestos derivados de espiro-oxindol en el tratamiento de hipercolesterolemia, hiperplasia benigna de prostata, pruritis, cancer
BRPI0719857A2 (pt) * 2006-10-12 2014-06-03 Xenon Pharmaceuticals Inc Compostos espiro-oxindol úteis no tratamento de doenças ou condições mediadas por canal de sódio.
US8101647B2 (en) * 2008-10-17 2012-01-24 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
CN105175433A (zh) * 2008-10-17 2015-12-23 泽农医药公司 螺羟吲哚化合物及其作为治疗剂的用途
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
PH12012500726A1 (en) 2009-10-14 2019-07-10 Xenon Pharmaceuticals Inc Synthetic methods for spiro-oxindole compounds
US20110086899A1 (en) * 2009-10-14 2011-04-14 Xenon Pharmaceuticals Inc. Pharmaceutical compositions for oral administration
RU2596488C2 (ru) 2010-02-26 2016-09-10 Ксенон Фармасьютикалз Инк. Фармацевтические композиции спиро-оксиндольного соединения для местного введения и их применение в качестве терапевтических агентов
US9682033B2 (en) 2015-02-05 2017-06-20 Teva Pharmaceuticals International Gmbh Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4760083A (en) * 1986-04-10 1988-07-26 E. I. Dupont De Nemours & Company 3,3-disubstituted indolines
GB8714371D0 (en) * 1987-06-19 1987-07-22 Smith Kline French Lab Process
EP0347698A1 (en) * 1988-06-14 1989-12-27 Schering Corporation Heterobicyclic compounds having antiinflammatory activity
US5006537A (en) * 1989-08-02 1991-04-09 Hoechst-Roussel Pharmaceuticals, Inc. 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones

Also Published As

Publication number Publication date
US5278162A (en) 1994-01-11
ZA936872B (en) 1995-03-17
CN1094406A (zh) 1994-11-02
AU4856893A (en) 1994-04-12
IL107003A0 (en) 1993-12-28
CA2144636A1 (en) 1994-03-31
TW248560B (enExample) 1995-06-01
WO1994006793A1 (en) 1994-03-31
EP0660833A1 (en) 1995-07-05

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