JPH08224208A - Fluorescence observing endoscope device - Google Patents

Fluorescence observing endoscope device

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Publication number
JPH08224208A
JPH08224208A JP7033995A JP3399595A JPH08224208A JP H08224208 A JPH08224208 A JP H08224208A JP 7033995 A JP7033995 A JP 7033995A JP 3399595 A JP3399595 A JP 3399595A JP H08224208 A JPH08224208 A JP H08224208A
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Japan
Prior art keywords
fluorescence
light
endoscope
image
optical filter
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Granted
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JP7033995A
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Japanese (ja)
Inventor
Mamoru Kaneko
Hitoshi Ueno
仁士 上野
守 金子
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Olympus Optical Co Ltd
オリンパス光学工業株式会社
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Priority to JP7033995A priority Critical patent/JPH08224208A/en
Publication of JPH08224208A publication Critical patent/JPH08224208A/en
Application status is Granted legal-status Critical

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/043Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging

Abstract

PURPOSE: To detect two kinds of fluorescence of specific wavelength without performing mechanical switching by a rotary filter, etc.
CONSTITUTION: The endoscope 4 of this fluorescence observing endoscope device 1 comprises a light guide 10 which introduces a laser beam emitted from a laser 9 to a living body inner cavity, a concave lens 11 which diffuses and illuminates the laser beam, an objective lens 12 which projects the fluorescent image of a lesion 3 on a color image pickup element 5 and an optical filter 13 which transmits specific wavelength of the fluorescent image. The optical filter 13 is provided with transmission characteristic to transmit a green color of 500-540nm and a red color of 640-700nm.
COPYRIGHT: (C)1996,JPO

Description

【発明の詳細な説明】 DETAILED DESCRIPTION OF THE INVENTION

【0001】 [0001]

【産業上の利用分野】本発明は、経内視鏡的に光を照射し、組織からの蛍光から癌等の病変部を観察診断する蛍光観察内視鏡装置に関し、特に蛍光の複数の特定波長を検出し、画像化する蛍光観察内視鏡装置に関する。 The present invention relates to a light irradiating the endoscopic via relates fluorescence fluorescence observation endoscope apparatus for observing diagnosing lesions such as cancer from from tissue, particularly a plurality of particular fluorescent detecting a wavelength for fluorescent observation endoscope apparatus for imaging.

【0002】 [0002]

【従来の技術】近年、生体からの自家蛍光や生体へ注入した薬物の蛍光を2次元画像として検出し、その蛍光象から生体組織の変性や癌等の疾患状態(例えば、疾患の種類や浸潤範囲)を診断する技術が米国特許45560 In recent years, detecting fluorescence of a drug injected into the autofluorescence and the living body from the biometric as a two-dimensional image, the disease state of degeneration and cancer, etc. of the living tissue from the fluorescent elephant (e.g., type of disease and invasive diagnostic techniques range) US Patent 45560
57号や5042494号に示されている。 It has been shown in 57 Nos and No. 5,042,494.

【0003】生体組織に光を照射するとその励起光より長い波長の蛍光が発生する。 [0003] Fluorescence of wavelengths longer than the excitation light is generated by irradiating light to the biological tissue. 生体内の蛍光物質としては、例えばNADH(ニコチンアミドアデニンヌクレオチド)やFMN(フラビンモノヌクレオチド)、ピリジンヌクレオチド等があり、最近では、これらの生体内因物質と疾患との相互関係が明確になりつつある。 The fluorescent substance in the living body, for example, NADH (nicotinamide adenine nucleotide) or FMN (flavin mononucleotide), there are pyridine nucleotides such as, recently, correlation between these biological endogenous substances and disease is becoming clear .

【0004】また、HpD(ヘマトポルフィリン),P [0004] In addition, HpD (hematoporphyrin), P
hotofrin,ALA(δ−amino levu hotofrin, ALA (δ-amino levu
linic acid)等の蛍光剤は、癌への集積性があり、これら蛍光剤を生体内に注入することによって、 linic acid) fluorescent agent, etc., there is accumulation of cancer, by injecting them fluorescent agent into a living body,
蛍光観察を行うことによって疾患部位を診断することができる。 It is possible to diagnose the disease site by performing fluorescence observation.

【0005】 [0005]

【発明が解決しようとする課題】上記の様な蛍光から経内視鏡的に病変部を診断する技術として、本出願人より出願された特願平5−304427号がある。 As to diagnose via the view from the fluorescence, such as the mirror to lesion [0005] technology, there is Japanese Patent Application 5-304427, filed than the present applicant. これは、 this is,
組織から発した自家蛍光をおよそ緑の領域と赤の領域の2つの帯域で検出し、これを画像間で処理表示している。 Detected by two bands of approximately the green region and the red region autofluorescence emitted from the tissue, and processing and displaying it in between images. 前記光の領域の切り換えには、回転フィルタが用いられている。 The switching region of the light, the rotary filter is used.

【0006】しかしながら、2つの波長領域の蛍光を検出するため回転フィルタ等、機械的に切り換えていたため、装置が大型でかつ高価となるといった問題がある。 However, such rotary filters for detecting fluorescence of two wavelength regions, because it was switched mechanically, there is a problem device is and expensive large.

【0007】本発明は、上記事情に鑑みてなされたものであり、回転フィルタ等による機械的切り換えなしで2 [0007] The present invention has been made in view of the above circumstances, 2 without mechanical switching by rotary filter or the like
つの特定波長の蛍光を検出できる蛍光観察内視鏡装置を提供することを目的としている。 One of the aims of providing a fluorescence observation endoscope apparatus fluorescence can detect a specific wavelength.

【0008】 [0008]

【課題を解決するための手段および作用】本発明の蛍光観察内視鏡装置は、経内視鏡的に励起光を体腔内臓器に照射し、組織からの蛍光を2次元画像として観察する蛍光観察内視鏡装置において、前記2次元画像を複数の異なる波長帯域に感度を有し電子信号に変換する撮像素子の受光側に、前記波長帯域のうち相異なる少なくとも2 Means and operation for solving the problems] fluorescence observation endoscope device of the present invention, fluorescence and through an endoscope to the excitation light is irradiated into a body cavity organ, to observe the fluorescence from the tissue as a two-dimensional image in endoscopic device, the light receiving side of the imaging device for converting said electronic signal having a sensitivity two-dimensional image into a plurality of different wavelength bands, different at least one of the wavelength bands 2
つの領域の波長を通過させる光学フィルタを配置させることで、前記光学フィルタにより前記波長帯域のうち相異なる少なくとも2つの領域の波長を通過させ、回転フィルタ等による機械的切り換えなしで2つの特定波長の蛍光を検出することを可能とする。 One of by arranging the optical filter that passes wavelengths of the region, the distinct least two of said wavelength band by the optical filter wavelengths in the region is passed through, by rotary filter or the like of two specific wavelengths without mechanical switching It makes it possible to detect the fluorescence.

【0009】 [0009]

【実施例】以下、図面を参照しながら本発明の実施例について述べる。 EXAMPLES The following describes embodiments of the present invention with reference to the drawings.

【0010】図1ないし図4は本発明の第1実施例に係わり、図1は蛍光により病変部を診断する蛍光観察内視鏡装置の全体の構成を示す構成図、図2は図1の光学フィルタの干渉フィルタの透過特性を示す特性図、図3は図1の光学フィルタの色フィルタの透過特性を示す特性図、図4は図1の光学フィルタの透過特性およびカラー撮像素子の分光特性を示す特性図である。 [0010] relates to the first embodiment of FIGS. 1-4 according to the present invention, FIG. 1 is a configuration diagram showing the overall configuration of a fluorescent endoscopic device for diagnosing lesions by fluorescence, FIG. 2 in FIG. 1 characteristics showing a transmission characteristic of the interference filter of the optical filter Figure, the spectral characteristics of FIG. 3 is a characteristic diagram showing the transmission characteristics of the color filters of the optical filter of FIG. 1, the transmission characteristics and color imaging element of the optical filter of FIG. 4 FIG. 1 it is a characteristic diagram showing the.

【0011】(構成)図1に示すように、本実施例の蛍光観察内視鏡装置1は、青色や紫外領域の光(励起光) [0011] (Configuration) As shown in FIG. 1, a fluorescent endoscopic device 1 of this embodiment, light in the blue or ultraviolet region (excitation light)
を発生する光源2と、その励起光を生体内腔に導き病変部3から発生する蛍光を観察する内視鏡4と、その内視鏡4に内蔵されているカラー撮像素子5を駆動し病変部3の蛍光像をビデオ信号に変換するカメラコントロールユニット6と、そのビデオ信号を処理し病変部3と正常部を認識しやすくするイメージプロセッサ7と、イメージプロセッサ7の出力を画像として表示するモニタ8とより構成される。 A light source 2 for generating an endoscope 4 to observe the fluorescence emitted from lesion 3 guides the excitation light to a living body lumen, lesion drives the color image pickup device 5 which is incorporated in its endoscope 4 fluorescent image parts 3 and camera control unit 6 for converting the video signal, a monitor for displaying the image processor 7 to easily recognize the diseased part 3 processes the video signal to the normal portion, the output of the image processor 7 as an image 8 and more composed.

【0012】前記光源2には、青色や紫外領域の光を発するエキシマ、He−Cd、アルゴン等のレーザ9が内蔵されている。 [0013] The light source 2, an excimer which emits light in the blue or ultraviolet region, the He-Cd, laser 9 as argon or the like is incorporated. 前記内視鏡4は、前記レーザ9より発したレーザ光を生体内腔に導くライトガイド10と、そのレーザ光を拡散し照明する凹レンズ11と、病変部3の蛍光像をカラー撮像素子5に投影する対物レンズ12 The endoscope 4 includes a light guide 10 for guiding the laser beam emitted from the laser 9 in vivo lumen, a concave lens 11 for illuminating diffuses the laser light, the fluorescence image of the lesion 3 to the color image pickup device 5 projection to the objective lens 12
と、対物レンズ12からの蛍光像のうち特定の波長を透過する光学フィルタ13とを備えて構成されている。 When is configured to include an optical filter 13 that transmits a specific wavelength of the fluorescence image from the objective lens 12.

【0013】蛍光観察内視鏡装置1の内視鏡4は、レーザ9より発したレーザ光を生体内腔に導くライトガイド10と、そのレーザ光を拡散し照明する凹レンズ11 [0013] concave lens 11 endoscope 4 in the fluorescence observation endoscope apparatus 1, to a light guide 10 for guiding the laser beam emitted from a laser 9 in vivo lumen to diffuse the laser light illumination
と、病変部3の蛍光像をカラー撮像素子5に投影する対物レンズ12と、前記蛍光像のうち特定の波長を透過する光学フィルタ13とを備えて構成されている。 If an objective lens 12 for projecting the fluorescence image of the lesion 3 to color image pickup device 5 is configured to include an optical filter 13 that transmits a specific wavelength of the fluorescent image. 光学フィルタ13は、500nm〜540nmの緑色と、640nm The optical filter 13, and green 500Nm~540nm, 640 nm
〜700nmの赤色を透過する透過特性を有している。 And a transmission characteristic of transmitting red ~700Nm.

【0014】光学フィルタ13は、図2に示すような透過特性を有する干渉フィルタと、図3に示すような透過特性を有する色フィルタとからなり、結局光学フィルタ13は図4の実線に示すような透過特性を有している。 [0014] The optical filter 13, an interference filter having a transmission characteristic as shown in FIG. 2, consists of a color filter having a transmission characteristic as shown in FIG. 3, after all the optical filter 13 as shown in solid line in FIG. 4 and a Do transmission characteristic.

【0015】尚、図示はしていないが前記光源2には白色光を発生するキセノンランプとレーザ9とキセノンランプの光を切り換えてライトガイド10に供給する切り換え手段がある。 [0015] Incidentally, there is a switching means for supplying to the light guide 10 by switching the light of the xenon lamp and a laser 9 and xenon lamps although not shown for generating the white light to the light source 2. また、内視鏡4には白色光による像を撮像する図示しない撮像素子が内蔵されている。 The imaging device in the endoscope 4 (not shown) captures an image by white light is incorporated.

【0016】(作用)レーザ9より出射したレーザ光は内視鏡4に内蔵したライトガイド10に入射され、生体内腔に導かれる。 [0016] (Function) laser light emitted from the laser 9 is incident on the light guide 10 incorporated in the endoscope 4 is guided to the living body lumen. そのレーザ光は凹レンズ11により拡散して生体内腔に照射される。 Its laser beam is irradiated to a living body lumen and diffused by the concave lens 11. そのレーザ光により病変部3および周辺の正常部より自家蛍光が放出され、これを対物レンズ12を通じ、カラー撮像素子5に投影する。 Its autofluorescence from lesion 3 and normal part of the periphery by a laser beam is emitted, which through the objective lens 12, to project the color image pickup device 5. この時、対物レンズ12とカラー撮像素子5の間には光学フィルタ13が配置されており、光学フィルタ1 At this time, there is disposed a optical filter 13 is provided between the objective lens 12 and the color image pickup device 5, the optical filter 1
3は図4の実線のごとく、500nm〜540nmの緑色と、640nm〜700nmの赤色を透過する。 3 as indicated by a solid line in FIG. 4, transmits and green 500Nm~540nm, red 640Nm~700nm.

【0017】一方、カラー撮像素子の分光感度は、図4 Meanwhile, the spectral sensitivity of the color imaging device, Figure 4
の破線の様に赤、緑、青の各領域に感度を持つ。 Like the dashed line with red, green, and sensitivity to each area of ​​the blue. すなわち、カラー撮像素子5には、前記光学フィルタ13とカラー撮像素子5の重なった部分、つまりカラー撮像素子5の緑の領域には500nm〜540nmの蛍光が、赤の領域には640nm〜700nmの蛍光が入射する。 That is, the color image pickup device 5, the overlapped part of the optical filter 13 and the color image pickup device 5, i.e. the fluorescence 500nm~540nm the green region of the color image pickup device 5, the red region of 640nm~700nm fluorescence is incident. このカラー撮像素子5をカメラコントロールユニット6により、 The camera control unit 6 the color image pickup device 5,
各々カラービデオ信号の例えばRGB信号に変換する。 Each converting the color video signal, for example the RGB signal.

【0018】念のため、R信号は640nm〜700nmの蛍光であり、G信号は500nm〜540nmの蛍光である。 [0018] As a precaution, R signal is the fluorescence of 640nm~700nm, G signal is fluorescence of 500nm~540nm. これらRGB信号の各々の重み付けや、直線性の補正をイメージプロセッサ7で行う。 Each weighting and these RGB signals, performed by the image processor 7 to correct the linearity. この重み付けは正常部位と病変部で見分けやすくかつ、誤診が少なくなる様設定してある。 And the weighting distinguishable by normal site and lesion, is set such that misdiagnosis is reduced.

【0019】なお、光学フィルタ13は概略480nm〜 [0019] The optical filter 13 is a schematic 480nm~
560nmと620nm〜700nm付近の光を含んで透過するように構成してもよい。 It may be configured to transmit contain light around 560nm and 620Nm~700nm.

【0020】(効果)以上の様に、光学フィルタ13の2つの透過する波長領域がカラー撮像素子の分光特性のR,G,Bのいずれかに対応することで、2つの波長領域の蛍光をR,G,Bのビデオ信号として取り出せる。 [0020] (Effect) above, the two transmission wavelength region of the optical filter 13 of the spectral characteristics of the color imaging device R, G, that corresponds to one of B, and the fluorescence of the two wavelength regions R, G, taken out as a video signal of B.
そして、各々の蛍光の波長領域を独立して重み付けや感度補正が行え、病変部と正常部がより明確に判別しやすく表示できる。 Then, independently wavelength regions of each phosphor can weighting or sensitivity correction, the lesion and the normal area can be displayed more clearly easily discriminated. また、蛍光像の撮像のための撮像素子が1つでよいため、装置の小型化も可能である。 Further, since the imaging device may be one for imaging the fluorescence image, it is also possible to miniaturize the apparatus.

【0021】次に第2実施例について説明する。 [0021] Next, a second embodiment will be described. 図5および図6は本発明の第2実施例に係わり、図5は蛍光観察内視鏡装置の内視鏡の先端の構成を示す構成図、図6 5 and 6 relates to a second embodiment of the present invention, FIG 5 is a configuration diagram showing a configuration of a distal end of an endoscope of the fluorescence observation endoscope apparatus, Fig. 6
は図5の内視鏡の先端の変形例の構成を示す構成図である。 Is a block diagram showing a configuration of a modification of the distal end of the endoscope in FIG. 第2実施例は第1実施例とほとんど同じであるので、異なる構成のみ説明し同一の構成には同じ符号をつけ説明は省略する。 Second embodiment are the almost same as the first embodiment, the description with the same reference numerals are given to the same components described only different configurations will be omitted.

【0022】蛍光から経内視鏡的に病変部を診断する技術として、特開昭63−234939号公報がある。 [0022] As a technique for diagnosing through an endoscope to lesion from the fluorescence, there is JP-A-63-234939. これは、内視鏡先端部の撮像素子と対物レンズとの間に蛍光のみを取り出す励起光カット用のフィルタが設けられ、さらに、このフィルタがワイヤで可動され光路中に挿脱できる様になっている。 This filter for the excitation light cut to take out only the fluorescence is provided between the imaging element and the objective lens of the endoscope distal end portion, further, the filter becomes as it inserted into and removed from the optical path is movable in the wire ing.

【0023】しかし、励起光カットフィルタをワイヤで可動する方法は、ワイヤの長さが内視鏡の長さに応じ、 [0023] However, a method for moving the excitation light cut filter in wire, depending on the length of the endoscope length of wire,
長くなり、また、内視鏡の曲げ等によりワイヤを動かす抵抗が増加し、このため、追従性や応答性が悪いという問題がある。 Longer, also move the wire resistance increases by such as bending of the endoscope, and therefore, there is a problem of poor trackability and responsiveness.

【0024】そこで、第2実施例では、撮像素子と対物レンズの間に蛍光観察用フィルタを圧電アクチュエータで自在に挿脱することで、応答性のよい切り換えを可能にする蛍光観察内視鏡装置について説明する。 [0024] In the second embodiment, the fluorescence observation filter between the imaging device and the objective lens by inserting and removing freely in the piezoelectric actuator, the fluorescence observation endoscope apparatus that enables good switching responsive It will be described.

【0025】第1実施例では、蛍光像を撮像するカラー撮像素子5のほかに、白色光像を撮像する図示しない撮像素子を備えて構成するとしたが、本実施例は第1実施例の光学フィルタ13を光路中に挿脱することで1つのカラー撮像素子5で蛍光像および白色光像の両方を切り換え観察するものである。 [0025] In the first embodiment, in addition to the color image pickup device 5 captures a fluorescent image, it has been to constitute an image pickup device (not shown) for imaging the white light image, this embodiment optics first embodiment filter 13 is to observe switching both fluorescence images and white light images by a single color image pickup device 5 by insertion and removal in the optical path.

【0026】(構成)図5に示すように、光学フィルター挿脱装置14は、内視鏡4の観察側先端内部にあり、 [0026] (Configuration) As shown in FIG. 5, an optical filter insertion and removal device 14 is located inside the observation side tip endoscope 4,
これは圧電アクチュエータ15と、圧電アクチュエータ15を摩擦力で保持するベース16と、回動可能に構成された回動軸18を有するな光学フィルタ13と、圧電アクチュエータ15を動作制御する図示しないアクチュエータ制御回路より構成される。 This piezoelectric actuator 15, a base 16 which holds the piezoelectric actuator 15 by a frictional force, an optical filter 13 Do having a rotation shaft 18 that is configured to be rotatable, an actuator control (not shown) controls the operation of the piezoelectric actuator 15 composed of a circuit. その他の構成は第1実施例と同じである。 The other structure is the same as the first embodiment.

【0027】(作用〕蛍光観察時は、図5の実線の様に、光学フィルタ13はカラー撮像素子5と対物レンズ12の間の光路中に挿入されている。光学フィルタ13 [0027] (action] during fluorescence observation, like the solid line in FIG. 5, the optical filter 13 is inserted in the optical path between the color image pickup device 5 and the objective lens 12. The optical filter 13
およびカラー撮像素子5は、第1実施例と同様に図4に示した特性を持っており、500nm〜540nm、640 And the color image pickup device 5, has a characteristic shown similarly in FIG. 4 in the first embodiment, 500Nm~540nm, 640
nm〜700nmの蛍光をビデオ信号のR信号とG信号として出力される。 The fluorescence of nm~700nm is output as R and G signals of the video signal.

【0028】一方、白色光観察時には、図示しなアいクチュエータ制御回路により圧電アクチュエータ15は、 On the other hand, when the white light observation, the piezoelectric actuator 15 by illustrated Shinano phase actuator control circuit,
図5の点線の様に移動し、光学フィルタ13は回動軸1 Move like a dotted line in FIG. 5, the optical filter 13 is the rotation shaft 1
8を中心に回転移動し光路中から除かれる。 8 rotates and moves around the removed from in the optical path. この時、この動作に同期して光源2が励起光から白色光に切り換えられ、カラー撮像素子5により通常のカラー画像としてとらえられる。 At this time, the light source 2 in synchronization with the operation is switched to the white light from the excitation light, it is captured by the color image pickup device 5 as a normal color image.

【0029】尚、圧電アクチュエータ15は圧電素子よりなり、この圧電素子の一端に正または負の電圧を短時間に加えると、その一端が急速に伸びまたは縮み、その時圧力により前進または後退する。 [0029] The piezoelectric actuator 15 comprises a piezoelectric element, when added to one end of the piezoelectric element a positive or negative voltage in a short time, one end rapidly increasing or contraction, forward or backward by the time pressure. そして圧電素子とベースの前記摩擦力を越えない様に電圧を戻すと圧電素子はその位置に保持される。 The piezoelectric element Returning voltage so as not to exceed the frictional force of the piezoelectric element and the base is held at that position. この動作を繰り返すことでしゃくとり虫状に前進、後退することができる。 Forward to temper tori insect-like by repeating this operation, it is possible to retreat.

【0030】(効果)このように本実施例では第1実施例の効果に加え、圧電アクチュエータ15を用いることで、小型かつ確実に蛍光像と白色光像の切り換えができる。 [0030] (Effect) As described above, in this embodiment in addition to the effects of the first embodiment, by using the piezoelectric actuator 15 can be switched between a small and reliable fluorescence image and the white light image.

【0031】図6は図5の変形例で、カラー撮像素子5 [0031] Figure 6 is a modification of FIG. 5, the color image pickup device 5
の代りにモノクロの撮像素子を使用した例である。 It is an example of using the monochrome image pickup device instead of.

【0032】(構成)図6の光学フィルター挿脱装置2 [0032] (Configuration) optical filter insertion and removal device 2 of FIG. 6
0は、第1の圧電アクチュエータ21と、圧電アクチュエーター21を摩擦力で保持する第1のベース22と、 0, a first piezoelectric actuator 21, a first base 22 which holds the piezoelectric actuator 21 by a frictional force,
回動可能な第1の光学フィルタ23と、第2の圧電アクチュエータ24と、圧電アクチュエータ24を摩擦力で保持する第2のベース25と、回動可能な第2の光学フィルタ26と、可視領域に感度のあるモノクロ撮像素子19とから構成される。 A rotatable first optical filter 23, a second piezoelectric actuator 24, a second base 25 which holds the piezoelectric actuator 24 by a frictional force, the second optical filter 26 to be rotatable, the visible region composed of monochrome image pickup device 19 for a sensitivity. 他の部分については、第1実施例と同様であり説明は省略する。 The other parts are the same as in the first embodiment description is omitted.

【0033】(作用)各々の光学フィルタ23,26 [0033] (action) each of the optical filters 23 and 26
は、各々の圧電アクチュエータ21、24により第1の溝27および第2の溝28に沿って回転移動される。 It is rotated and moved by each of the piezoelectric actuators 21, 24 along the first groove 27 and second groove 28. 例えば光学フィルタ23は500nm〜540nmの光を透過し、光学フィルタ26は640nm〜700nmの光を透過する。 For example, the optical filter 23 transmits light of 500Nm~540nm, the optical filter 26 transmits light of 640Nm~700nm. 一方、モノクロ撮像素子19は、可視領域全般に感度を持つ。 On the other hand, the monochrome image pickup device 19 has a sensitivity in the visible region in general. すなわち、光学フィルタ23,26を圧電アクチュエーター21,24により順次挿脱することで、画像を各波長におけるビデオ信号として取り出せる。 That is, by sequentially inserting and removing the optical filter 23, 26 by the piezoelectric actuator 21 and 24, retrieve the image as a video signal at each wavelength. また、白色光観察の際は、光学フィルタ23,26 Further, when the white light observation, the optical filter 23 and 26
の両方とも光路中より除き、光源2よりR,G,Bの光を順次照射することで白色光像を得る。 Of both the exception from the optical path to obtain R from the light source 2, G, a white light image by sequentially irradiating the light of B. その他の作用は第1実施例と同じである。 Other operations are the same as the first embodiment.

【0034】(効果)したがって、第1実施例の効果に加え、モノクロ撮像素子を使うことで分解能の高い蛍光画像および白色光画像を得ることができる。 [0034] (Effect) Thus, in addition to the effects of the first embodiment, it is possible to obtain a high fluorescence image and the white-light image resolution by using a monochrome image pickup device.

【0035】次に第3実施例について説明する。 [0035] Next, a third embodiment will be described. 図7は本発明の第3実施例に係る蛍光観察内視鏡装置の内視鏡の先端の構成を示す構成図である。 Figure 7 is a block diagram showing a third distal end of the endoscope in the fluorescence observation endoscope apparatus according to an embodiment configuration of the present invention. 第3実施例は第1実施例とほとんど同じであるので、異なる構成のみ説明し同一の構成には同じ符号をつけ説明は省略する。 Third embodiment are the almost same as the first embodiment, the description with the same reference numerals are given to the same components described only different configurations will be omitted.

【0036】第1及び第2実施例のように、励起光の様な紫外から青色の光をライトガイド10を構成する光ファイバに通すと、そのファイバ自体が蛍光を発生し、励起光以外の光が生体に照射され、生体からの自家蛍光と一緒に検出してしまい、蛍光像のコントラスト低下の原因となる虞がある。 [0036] As in the first and second embodiments, when passed from the ultraviolet, such as excitation light to the optical fibers constituting the light guide 10 the blue light, the fiber itself is generated fluorescence, other than the excitation light light is irradiated to the living body, will be detected with autofluorescence from biological, there is a fear to cause contrast deterioration of the fluorescent image.

【0037】そこで、第3実施例では、第1実施例の目的に加え、ライトガイド照射端側に励起光は通し、それ以外、特に長波長側の光を吸収または反射するフィルタを配置することで、よりコントラストの高い蛍光画像を提供することを目的としている。 [0037] Therefore, in the third embodiment, in addition to the purpose of the first embodiment, through the excitation light to the light guide radiation end, otherwise, placing the filter in particular absorbs or reflects light of a long wavelength side in, and its object is to provide a more fluorescence images with high contrast.

【0038】図7は光源2から励起光が入射した時、ライトガイドで発生する蛍光を遮断する構成を示している。 [0038] Figure 7 when the excitation light is incident from the light source 2 shows a configuration for blocking the fluorescence emitted by the light guide.

【0039】すなわち、第3実施例においては、図7に示すように、内視鏡4の先端内にライトガイド10で発生する蛍光を遮断する蛍光遮断装置29を備えており、 [0039] That is, in the third embodiment, as shown in FIG. 7, provided with a fluorescence cut-off device 29 for cutting off the fluorescence emitted by the light guide 10 in the distal end of the endoscope 4,
ライトガイド10の蛍光遮断装置29は、光源2の励起光のみを透過する励起光透過フィルタ30と、励起光透過フィルタ30を光路中から挿脱させるため回転移動させる圧電アクチュエータ31と、圧電アクチュエータ3 Fluorescence breaker of the light guide 10 29, an excitation light transmission filter 30 which transmits only the excitation light source 2, a piezoelectric actuator 31 for rotating movement in order to inserting and removing an excitation light transmitting filter 30 from the optical path, the piezoelectric actuator 3
1を摩擦力で保持するベース32とよりなる。 The more the base 32 for holding a frictional force. その他の構成は第1実施例と同じである。 The other structure is the same as the first embodiment.

【0040】(作用)まず、蛍光観察時ライトガイド1 [0040] (Operation) First, the fluorescence observed when light guide 1
0に励起光、特に青色から紫外光のエネルギの高い光が入射されると、ライトガイド10の素材に起因する蛍光が可視領域に発生する。 0 to the excitation light, especially high light having energy of ultraviolet light from the blue is incident, fluorescence due to the material of the light guide 10 is produced in the visible region. そこで、励起光透過フィルタ3 Therefore, the excitation light transmitting filter 3
0で励起光のみを通し、蛍光を除去できる。 0 through only the excitation light can be removed fluorescence. 一方、白色光観察時は励起光フィルタ30を光路中から除くことで生体内腔に白色光を照射できる。 On the other hand, when the white light observation can emit white light to a living body lumen by excluding excitation light filter 30 from the optical path.

【0041】なお、励起光透過フィルタ30を光路中から挿脱させる圧電アクチュエータ31の作用は、図5における第2実施例の圧電アクチュエータ15と同じであるので説明は省略する。 It should be noted, the action of the piezoelectric actuator 31 for inserting and removing the excitation light transmitting filter 30 from the optical path is described is the same as the piezoelectric actuator 15 of the second embodiment in FIG. 5 will be omitted.

【0042】(効果)本実施例によればライトガイドの蛍光による反射光が除去できるので、組織からの自家蛍光をS/Nよく検出でき、より病変部と正常部の判別能力が高くなる。 [0042] Since the (effect) light reflected by the light guides of fluorescence according to the present embodiment can be removed, the autofluorescence from the tissue can be detected well S / N, discrimination performance more lesion and the normal portion is higher.

【0043】次に第4実施例について説明する。 Next, a fourth embodiment will be described. 図8および図9は本発明の第4実施例に係わり、図8は蛍光観察内視鏡装置の構成を示す構成図、図9は図8の光プローブの構成を示す断面図である。 8 and 9 relates to a fourth embodiment of the present invention, FIG. 8 is a configuration diagram showing the configuration of a fluorescent endoscopic device, Fig. 9 is a sectional view of an optical probe of FIG. 第4実施例は第1実施例とほとんど同じであるので、異なる構成のみ説明し同一の構成には同じ符号をつけ説明は省略する。 Fourth embodiment are the almost same as the first embodiment, the description with the same reference numerals are given to the same components described only different configurations will be omitted.

【0044】第4実施例は、励起光を内視鏡4のライトガイド10の代りに内視鏡4のチャンネルを通した光プローブを使用し励起光を供給する例である。 [0044] The fourth embodiment is an example of supplying the pumping light by using the optical probe through the channel of the endoscope 4 in place of the light guide 10 of the endoscope 4 the excitation light.

【0045】すなわち、本実施例は、図8に示すように、レーザ9の励起光が内視鏡4のチャンネル33を挿通する光プローブ34を介し、生体内腔に照射されるようになっている。 [0045] That is, this embodiment, as shown in FIG. 8, through the optical probe 34 to the excitation light of the laser 9 is inserted through the channel 33 of the endoscope 4, so as to be irradiated on the living body lumen there. 尚、光源2には白色光源例えばXeランプ35が内蔵されている。 Incidentally, the white light source for example Xe lamp 35 is incorporated in the light source 2.

【0046】図9に示すように、光プローブ34は励起光を伝送する光ファイバ36と、励起光のみの波長を通す励起光透過フィルタ37と、励起光を生体内腔で拡散させる凹レンズ38と、前記光ファイバ36、励起光透過フィルタ37、凹レンズ38を固定するパイプ39 [0046] As shown in FIG. 9, the optical probe 34 and the optical fiber 36 for transmitting the excitation light, an excitation light transmission filter 37 to pass a wavelength of only the excitation light, a concave lens 38 for diffusing the excitation light in vivo lumen pipe 39 for fixing the optical fiber 36, the excitation light transmission filter 37, a concave lens 38
と、光ファイバ36を保護するチューブ40とより構成される。 When more composed and tube 40 for protecting the optical fiber 36.

【0047】その他の構成および作用は第1実施例と同じである。 [0047] The other structure and action are same as in the first embodiment.

【0048】本実施例によれは、励起光専用の光プローブ34を備えているので、第3実施例の様なアクチュエータ31を必要とせずに、第3実施例と同様な効果を得ることができる。 [0048] According to the present embodiment is provided with the excitation light only optical probe 34, without requiring the actuator 31, such as a third embodiment, it is possible to obtain the same effects as in the third embodiment it can.

【0049】ここで、上記各実施例における白色光および励起光による白色光像および励起光像を取得制御について説明する。 [0049] Here, a description will be given acquisition control the white light image and excited light image by the white light and the excitation light in the above embodiments.

【0050】図10は白色光像および励起光像の取得制御を行う蛍光観察内視鏡装置の構成を示す構成図である。 [0050] FIG. 10 is a configuration diagram showing the configuration of a fluorescent endoscopic device to acquire control of the white light image and excited light image.

【0051】図10は、蛍光観察のための蛍光観察内視鏡装置41であり、この蛍光観察内視鏡装置41は、白色光および励起光を発生するXeランプやレーザおよび白色光または励起光を選択する切り換え装置を内蔵した光源42と、その光源42からの光を生体内腔に伝送し生体組織の白色光像および蛍光像を得る内視鏡43と、 [0051] Figure 10 is a fluorescence observation endoscope device 41 for the fluorescence observation, the fluorescence observation endoscope apparatus 41, Xe lamp or a laser and white light or excitation light to generate white light and the excitation light a light source 42 with a built-in switching device for selecting an endoscope 43 with light from the light source 42 to obtain a white light image and a fluorescence image of the transmission to the biological tissue in vivo lumen,
内視鏡43の接眼部44に着脱自在に装着される白色光像および蛍光像を撮像する白色光像用カメラおよび蛍光像用高感度カメラ(図示せず)とを内蔵し前記光源42 The endoscope 43 (not shown) of the eyepiece portion 44 detachably mounted by white light image camera for imaging the white light image and fluorescent image and the high-sensitivity camera for fluorescence image and a built-in light source 42
の光に同期して各々のカメラを切り換える切り換え装置(図示せず)を有するカメラ45と、前記カメラ45を駆動しビデオ信号に変換するカメラコントロールユニット46と、そのビデオ信号を処理し病変部と正常部を認識しやすくするイメージプロセッサ47と、イメージプロセッサ44の出力を画像として表示するモニタ48 A camera 45 having a switching device for switching the respective camera (not shown) in synchronism with the light, the camera control unit 46 which converts the video signal to drive the camera 45, and the lesion processes the video signal an image processor 47 to easily recognize the normal part, a monitor 48 for displaying the output of the image processor 44 as an image
と、白色光像または蛍光像を記録するVTR49、白色光像または蛍光像をプリントアウトするビデオプリンタ50と、光源42、カメラコントロールユニット46、 If, VTR49 to record white light image or a fluorescent image, a video printer 50 for printing out the white light image or a fluorescent image, a light source 42, camera control unit 46,
VTR49、ビデオプリンタ50を制御するコントロールユニット51とから構成される。 VTR49, and a control unit 51 which controls the video printer 50.

【0052】内視鏡43は、細長な挿入部52と、挿入部52の基端に設けられた操作部53とからなり、コントロールユニット51は、内視鏡43の操作部53に組み込まれている押しボタン状のスイッチA54、スイッチB55、モード切り換えスイッチ56により遠隔操作ができる。 The endoscope 43 includes an elongated insertion portion 52 consists of the operation section 53 provided at the proximal end of the insertion portion 52, the control unit 51 is incorporated in the operation unit 53 of the endoscope 43 pushbutton shaped switch A54 which are, switch B55, it is remotely controlled by the mode changeover switch 56. 図中のボタン57は内視鏡の送気送水および吸引機能を動作させるためのものである。 Button 57 in the figure is for operating the air water and suction functions of the endoscope. また、内視鏡43の操作部53からはユニバーサルケーブル58が延出しており、このユニバーサルケーブル58の先端は光源42に着脱自在に接続されている。 Further, from the operation unit 53 of the endoscope 43 and the universal cable 58 is extended, the tip of the universal cable 58 is detachably connected to the light source 42. そして光源42からの白色光または励起光は、ユニバーサルケーブル58 The white light or excitation light from the light source 42, the universal cable 58
および挿入部52内を挿通する図示しないライトガイドにより内視鏡43の先端に伝送され、内視鏡先端より前方の病変部に照射され、病変部からの白色光像または蛍光像が挿入部52および操作部53を挿通する図示しないイメージガイドにより接眼部44に伝送されカメラ4 And is transmitted to the distal end of the endoscope 43 by the light guide (not shown) inserted through the insertion portion 52, it is irradiated to the diseased part of the front of the endoscope tip, white light image or a fluorescent image insertion portion 52 from the lesion and a camera 4 is transmitted to an eyepiece unit 44 by the image guide (not shown) inserted through the operation section 53
5で撮像するようになっている。 It is adapted to imaging with 5.

【0053】このような構成により、スイッチA54、 [0053] With such a configuration, switch A54,
スイッチB55およびモード切り換えスイッチ56を操作することで、蛍光像と白色光像の切り換え、動画と静止画が切り換えが可能となる。 By operating the switch B55 and a mode selector switch 56, switching of the fluorescent image and the white light image, moving images and still images is can be switched.

【0054】すなわち、まず、モード切り換えスイッチ56を押すと、表1に示すように、モードが1,2, [0054] That is, firstly, pressing the mode switch 56, as shown in Table 1, mode 1, 2,
3,1……と順次切り換わり、例えば、モード1の状態でスイッチA54を押すと、白色光像から蛍光像に切り換わる。 3,1 ...... sequentially switched, for example, pressing the switch A54 in the state of mode 1, switching from the white light image to the fluorescent image. この時コントロールユニットは光源42で白色光から励起光へ切り換わり、カメラ45で白色光像用カメラから蛍光用高感度カメラに切り換える。 In this case the control unit is switched from the white light source 42 to the excitation light, it switches from the white light image camera in fluorescence for high-sensitivity camera camera 45. ここで、スイッチB55を押すと静止画になり、さらに押すと動画になる。 Here, to still frame and pressing the switch B55, it becomes moving further pressed.

【0055】 [0055]

【表1】 [Table 1] モード2では、蛍光用高感度カメラの感度調整が可能であり、スイッチA54を押すと、感度は向上しスイッチB55を押すと減少する。 In mode 2, it is possible sensitivity adjustment fluorescence for high-sensitivity camera, press the switch A54, the sensitivity is reduced and improved pressing the switch B55. モード3ではスイッチA5 Mode 3, the switch A5
4、スイッチB55の操作により、VTR49の記録のON/OFFおよびビデオプリンタ50によるプリントアウトができる。 4, the operation of the switch B55, it is printed out by the ON / OFF and the video printer 50 records the VTR49. 尚、各モードと、スイッチの機能の配列および他の機能はこの限りではない。 Incidentally, each mode is not limited to this arrangement and other functions of the switch functions.

【0056】[付記] (付記項1)経内視鏡的に励起光を体腔内臓器に照射し、組織からの蛍光を2次元画像として観察する蛍光観察内視鏡装置において、前記2次元画像を複数の異なる波長帯域に感度を有し電子信号に変換する撮像素子の受光側に、前記波長帯域のうち相異なる少なくとも2つの領域の波長を通過させる光学フィルタを配置させた蛍光観察内視鏡装置。 [0056] [Appendix] (Note 1) through an endoscope to the excitation light is irradiated into a body cavity organ, in a fluorescence observation endoscope apparatus for observing fluorescence as two-dimensional images from the tissue, the two-dimensional image on the light receiving side of the image pickup element for converting an electronic signal having a sensitivity to different wavelength bands, fluorescence observation endoscope is disposed an optical filter that passes wavelengths of different at least two regions of the wavelength band apparatus.

【0057】(付記項2)前記撮像素子は内視鏡先端部に配置され、前記光学フィルタは内視鏡対物レンズと前記撮像素子の光路中に配置されている付記項1記載の蛍光観察内視鏡装置。 [0057] (Note 2) the imaging element is arranged in the endoscope tip portion, wherein the optical filter is an endoscope objective lens and the fluorescence within the observation according to Note 1, wherein disposed on the light path of the image pickup element endoscope apparatus.

【0058】(付記項3)前記撮像素子は赤、緑、青色の各々の領域に感度を持つ付記項1記載の蛍光観察内視鏡装置。 [0058] (Note 3) The imaging device red, green, fluorescent endoscopic device according to Note 1, wherein having sensitivity to blue for each area.

【0059】(付記項4)前記フィルタは前記撮像素子の赤、緑の領域の一部の波長帯域を透過し、それ以外は反射または吸収する付記項3記載の蛍光観察内視鏡装置。 [0059] (Note 4) Red of the filter is the imaging device, and transmits a part of the wavelength band of green areas, the fluorescence observation endoscope apparatus according to Note 3 wherein reflected or absorbed otherwise.

【0060】(付記項5)前記フィルタの波長は概略4 [0060] (Note 5) wavelength of the filter is a schematic 4
80nm〜560nmと620nm〜700nm付近の光を含んで透過する付記項4記載の蛍光観察内視鏡装置。 Fluorescence observation endoscope apparatus according to Note 4, wherein the transmitting includes light around 80nm~560nm and 620Nm~700nm.

【0061】(付記項6)経内視鏡的に励起光を体腔内臓器に照射し、組織からの蛍光を2次元画像として観察する蛍光観察内視鏡装置において、前記内視鏡先端に配置された2次元画像を電子信号に変換する撮像素子と、 [0061] The (Note 6) through an endoscope to the excitation light is irradiated into a body cavity organ, in a fluorescence observation endoscope apparatus for observing fluorescence as two-dimensional images from the tissue, disposed in the endoscope tip an image sensor for converting the two-dimensional image to an electronic signal,
内視鏡対物レンズとの光路の間に、特定の波長領域を透過する光学フィルタを圧電素子からなる移動可能なアクチュエータにより挿脱する手段を有した蛍光観察内視鏡装置。 Between the optical path of the endoscope objective lens, a fluorescence observation endoscope apparatus having a means for inserting and removing the movable actuator comprising an optical filter from the piezoelectric element for transmitting a specific wavelength region.

【0062】(付記項7)前記撮像素子は赤、緑、青色の各々の領域に感度を持つ付記項6記載の蛍光観察内視鏡装置。 [0062] (Note 7) The imaging device red, green, fluorescent endoscopic device according to Note 6, wherein having sensitivity to blue for each area.

【0063】(付記項8)前記光学フィルタは前記撮像素子の赤、緑の領域の一部の波長帯域を透過し、それ以外は反射または吸収する付記項7記載の蛍光観察内視鏡装置。 [0063] Red (Note 8) The optical filter the image sensor, the green is transmitted through the part of the wavelength band region, the fluorescence observation endoscope apparatus according to Note 7, wherein reflecting or absorbing otherwise.

【0064】(付記項9)前記光学フィルタの波長は概略480nm〜560nmと620nm〜700nm付近の光を含んで透過する付記8記載の蛍光観察内視鏡装置。 [0064] (Note 9) wherein the wavelength of the optical filter the fluorescence observation endoscope apparatus according to Supplementary Note 8, wherein the transmitting includes a light near schematic 480nm~560nm and 620Nm~700nm.

【0065】(付記項10)前記撮像素子は可視領域に一様に感度を持つ付記項6記載の蛍光観察内視鏡装置。 [0065] (Note 10) The image pickup device fluorescent endoscopic device according to Note 6, wherein with uniform sensitivity in the visible region.

【0066】(付記項11)前記光学フィルタおよび前記アクチュエータは少なくとも2つであり、各々の光学フィルタの透過波長領域が異なる付記項10記載の蛍光観察内視鏡装置。 [0066] (Note 11) The optical filter and the actuator is at least two, fluorescent endoscopic device of the transmission wavelength region of each of the optical filter is different according to Note 10, wherein.

【0067】(付記項12)前記光学フィルタの波長は概略480nm〜560nmと620nm〜700nm付近の光を含んで透過する付記項11記載の蛍光観察内視鏡装置。 [0067] (Note 12) wherein the wavelength of the optical filter the fluorescence observation endoscope apparatus according to Note 11, wherein the transmitting includes a light near schematic 480nm~560nm and 620Nm~700nm.

【0068】(付記項13)経内視鏡的に励起光を体腔内臓器に照射し、組織からの蛍光を2次元画像として観察する蛍光観察内視鏡装置において、前記励起光を伝送する手段の光出射端に励起光のみを透過し、少なくともその波長より長い領域を反射または吸収する励起光透過フィルターを配置した蛍光観察内視鏡装置。 [0068] The (Additional Item 13) through an endoscope to the excitation light is irradiated into a body cavity organ, in a fluorescence observation endoscope apparatus for observing fluorescence as two-dimensional images from the tissue, means for transmitting the excitation light of transmitting only excitation light to the light emitting end, at least a reflecting or absorbing longer region wavelength excitation light transmitting filter fluorescence observation endoscope apparatus arranged.

【0069】(付記項14)前記励起光伝送手段は、内視鏡に内蔵されたライトガイドである付記項13記載の蛍光観察内視鏡装置。 [0069] (Note 14) the excitation light transmitting means, the fluorescence observation endoscope apparatus according to Note 13, wherein the light guide incorporated in the endoscope.

【0070】(付記項15)前記励起光伝送手段は内視鏡のチャンネルを挿通できる太さの光プローブである付記項13記載の蛍光観察内視鏡装置。 [0070] (Note 15) the excitation light transmitting means fluorescence observation endoscope device according to Note 13, wherein the optical probe thickness capable through a channel of an endoscope.

【0071】(付記項16)前記励起光透過フィルタは450nmより短い波長を含んで透過する付記項13記載の蛍光観察内視鏡装置。 [0071] (Note 16) the excitation light transmission filter fluorescence observation endoscope apparatus according to Note 13, wherein the transmitting comprises wavelengths shorter than 450nm.

【0072】(付記項17)前記励起光透過フィルタは光路中に挿脱可能である付記項14記載の蛍光観察内視鏡装置。 [0072] (Note 17) the excitation light transmission filter fluorescence observation endoscope device according to Note 14, wherein the removably in the optical path.

【0073】(付記項18)前記挿脱手段は圧電素子からなる移動可能なアクチュエータである付記項17記載の蛍光観察内視鏡装置。 [0073] (Note 18) said insertion and removal means fluorescence observation endoscope device according to Note 17, wherein the movable actuator composed of a piezoelectric element.

【0074】 [0074]

【発明の効果】以上説明したように本発明の蛍光観察内視鏡装置によれば、2次元画像を複数の異なる波長帯域に感度を有し電子信号に変換する撮像素子の受光側に、 According As described above, according to the present invention the fluorescence observation endoscope apparatus of the present invention, the light receiving side of the image pickup element for converting an electronic signal having a sensitivity two-dimensional image into a plurality of different wavelength bands,
波長帯域のうち相異なる少なくとも2つの領域の波長を通過させる光学フィルタを配置させているので、光学フィルタにより波長帯域のうち相異なる少なくとも2つの領域の波長を通過させ、回転フィルタ等による機械的切り換えなしで2つの特定波長の蛍光を検出することができるという効果がある。 Since is arranged an optical filter that passes wavelengths of different at least two regions of the wavelength band is passed through the wavelength distinct least two areas of the wavelength band by the optical filter, mechanical switching by rotary filter or the like there is an effect that two fluorescence can be detected at a specific wavelength without.

【図面の簡単な説明】 BRIEF DESCRIPTION OF THE DRAWINGS

【図1】本発明の第1実施例に係る蛍光により病変部を診断する蛍光観察内視鏡装置の全体の構成を示す構成図 Diagram showing the overall configuration of a fluorescent endoscopic device by fluorescence according to the first embodiment for diagnosing a lesion of the present invention; FIG

【図2】図1の光学フィルタの干渉フィルタの透過特性を示す特性図 [Figure 2] characteristic diagram showing the transmission characteristic of the interference filter of the optical filter of FIG. 1

【図3】図1の光学フィルタの色フィルタの透過特性を示す特性図 [Figure 3] characteristic diagram showing the transmission characteristics of the color filters of the optical filter of FIG. 1

【図4】図1の光学フィルタの透過特性およびカラー撮像素子の分光特性を示す特性図 [4] characteristic diagram showing the spectral characteristics of transmission characteristics and color imaging element of the optical filter of FIG. 1

【図5】本発明の第2実施例に係る蛍光観察内視鏡装置の内視鏡の先端の構成を示す構成図 Figure 5 is a configuration diagram showing a front end structure of an endoscope of the fluorescence observation endoscope apparatus according to a second embodiment of the present invention

【図6】図5の内視鏡の先端の変形例の構成を示す構成図 Figure 6 is a configuration diagram showing a configuration of a distal end of a modified example of the endoscope of FIG. 5

【図7】本発明の第3実施例に係る蛍光観察内視鏡装置の内視鏡の先端の構成を示す構成図 Figure 7 is a configuration diagram showing a front end structure of an endoscope of the fluorescence observation endoscope apparatus according to a third embodiment of the present invention

【図8】本発明の第4実施例に係る蛍光観察内視鏡装置の構成を示す構成図 Figure 8 is a configuration diagram showing the configuration of a fluorescent endoscopic device according to a fourth embodiment of the present invention

【図9】図8の光プローブの構成を示す断面図 Figure 9 is a sectional view showing a structure of an optical probe of FIG. 8

【図10】白色光像および励起光像の取得制御を行う蛍光観察内視鏡装置の構成を示す構成図 Figure 10 is a configuration diagram showing the configuration of a fluorescent endoscopic device to acquire control of the white light image and excited optical image

【符号の説明】 DESCRIPTION OF SYMBOLS

1…蛍光観察内視鏡装置 2…光源 3…病変部 4…内視鏡 5…カラー撮像素子 6…カメラコントロールユニット 7…イメージプロセッサ 8…モニタ 9…レーザ 10…ライトガイド 11…凹レンズ 12…対物レンズ 13…光学フィルタ 1 ... fluorescence observation endoscope apparatus 2 ... light source 3 ... lesion 4 ... endoscope 5 ... color image pickup device 6 ... camera control unit 7 ... image processor 8 ... monitor 9 ... laser 10 ... light guide 11 ... concave lens 12 ... objective lens 13 ... optical filter

Claims (1)

    【特許請求の範囲】 [The claims]
  1. 【請求項1】 経内視鏡的に励起光を体腔内臓器に照射し、組織からの蛍光を2次元画像として観察する蛍光観察内視鏡装置において、 前記2次元画像を複数の異なる波長帯域に感度を有し電子信号に変換する撮像素子の受光側に、前記波長帯域のうち相異なる少なくとも2つの領域の波長を通過させる光学フィルターを配置させたことを特徴とする蛍光観察内視鏡装置。 1. A menstrual endoscope exciting light is irradiated into a body cavity organ, in a fluorescence observation endoscope apparatus for observing fluorescence as two-dimensional images from the tissue, the different wavelength bands a two-dimensional image with multiple on the light receiving side of the image pickup element for converting an electronic signal has sensitivity, fluorescence observation endoscope apparatus which is characterized in that is arranged an optical filter for passing wavelengths of different at least two regions of the wavelength band .
JP7033995A 1995-02-22 1995-02-22 Fluorescence observing endoscope device Granted JPH08224208A (en)

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JPH08224208A true JPH08224208A (en) 1996-09-03

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