JPH08175965A - Skin cosmetic - Google Patents

Abstract

PURPOSE: To obtain a skin cosmetic excellent in aged skin-curing effect such as chapped skin-curing effect, corneum-improving effect, stratum corneum turnover-accelerating effect and skin-beautifying effect, formulated with salt(s) of specific organic acid(s) such as malic acid and nicotinic alcohol. CONSTITUTION: This cosmetic stands formulated with pref. 0.001-5.0wt.% of slat(s) of nicotinic alcohol and at least one kind of organic acid selected from malic acid, citric acid, succinic acid, lactic acid, glycolic acid, fumaric acid and maleic acid. This cosmetic is applied in the form of lotion, milky lotion, cream, park, etc.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin cosmetic having excellent aged skin improving effect (rough skin improving effect, keratin improving effect, horny layer turnover accelerating effect, beautiful skin effect, etc.).

[0002]

2. Description of the Related Art Aged skin has a dry and non-smooth surface, and rough skin and exfoliation of keratinocytes are also recognized. In addition, it is known that the number of cells in the epidermis is decreased and the metabolic rate of the entire epidermis and the turnover rate of the stratum corneum are slowed due to the decrease in cell metabolism. On the other hand, in the connective tissue of the dermis, collagen fibers become thin, the interstices of the fibers widen, and matrix components such as hyaluronic acid also decrease, which causes wrinkles and sagging. Furthermore, nutritional supplementation and removal of waste products cannot be performed smoothly due to a decrease in capillary density and poor circulation of peripheral blood flow. From the above viewpoints, various symptoms of aging skin are improved by improving poor circulation in aging skin, and thus various skin blood circulation promoting substances and cell activating components have been studied.

It has been proposed that a therapeutic and protective drug for the skin containing vitamin E or the like is effective against skin eczema, inflammation, wrinkles and the like (Japanese Patent Laid-Open No. 61-40210). However, in practice, vitamin E alone or vitamin E
Even if an external medicine containing this and other ingredients is applied to the skin, it is effective enough to repair or improve the tissue function, restore the function originally possessed by the skin, and exert a remarkable effect on the antiaging effect of the skin. It didn't come out to the point.

An object of the present invention is to provide a skin cosmetic having an excellent effect of preventing skin aging (effect of improving rough skin, effect of improving keratin, effect of accelerating turnover of stratum corneum, effect of beautiful skin, etc.).

[0005]

Means for Solving the Problems As a result of intensive studies in view of the above circumstances, the present inventors have selected from the group consisting of malic acid, citric acid, succinic acid, lactic acid, glycolic acid, fumaric acid, and maleic acid. Skin cosmetics containing one or more salts of organic acid and nicotinic alcohol are excellent in improving aging skin (effects of improving rough skin, improving keratin, accelerating turnover of stratum corneum, and skin beautifulness). After confirmation, the present invention was completed.

The skin cosmetic composition of the present invention containing a salt of nicotinic alcohol and a specific organic acid has high permeability to the skin, promotes proliferation and differentiation of epidermal cells, and further expands peripheral blood vessels. When it is applied to aged skin by enhancing or improving the skin function and restoring or improving the function originally possessed by the skin to keep the skin in a healthy state, a remarkable effect is observed.

Nicotinic alcohol (3-pyridinemethanol) is a known substance and is used as a liver disease and brain function improving agent as a drug having a peripheral blood flow promoting action. Further, as the type of organic acid used in the present invention,
Malic acid, citric acid, succinic acid, lactic acid, glycolic acid,
Examples include fumaric acid and maleic acid, but especially malic acid,
Citric acid, succinic acid, lactic acid and glycolic acid are preferred.

The above organic acid salt of nicotinic alcohol can be easily prepared by the following method. Nicotinic alcohol to 1-30%, organic acids 1-1
Dissolve in 0% each in ethyl alcohol. next,
Both solutions are mixed at room temperature so as to be equimolar amounts and left for about 1 hour. After that, the generated crystals can be filtered to obtain the desired organic acid salt of nicotinic alcohol.
When crystals do not form, the solvent ethanol is distilled off under reduced pressure to obtain a liquid organic acid salt of nicotinic alcohol.

The amount of organic acid salt of nicotinic alcohol is 0.001 to 0.001 based on the total amount of skin cosmetics.
5.0% by weight is preferred. If the compounded amount is less than the lower limit of each of these, the effect aimed at by the present invention is small, while if it exceeds the upper limit, the effect commensurate with the increase cannot be obtained.

The skin cosmetic of the present invention can be applied to, for example, lotions, emulsions, creams, packs and the like. In addition to the above, a colorant, a fragrance, an antiseptic, a surfactant, a pigment, an antioxidant and the like can be appropriately added to the skin cosmetic of the present invention within the range where the object of the present invention is achieved.

[0011]

EXAMPLES The present invention will be described in detail below based on examples and comparative examples.

First, test methods for rough skin effect test, keratin improvement effect test, horny layer turnover measurement test, and sensory test (skin beauty effect test) will be described.

[Rough skin improving effect test] The effect of continuous application for 4 weeks was investigated for 10 middle-aged and elderly subjects having rough skin on the lower leg. 1 day per day on the left lower leg outer test site of the subject
About 0.5 g of the sample was applied once, and the condition of the skin before and after the start of the test was evaluated according to the criteria shown in the table below. The lower right leg was not coated with the sample and served as a control.

[0014]

[Table 1]

The judgment results of the test site before and after the test and the control site are compared, and when the skin dryness is improved by two stages or more (for example, + → −, ++ → ±), it is effective when one stage is improved. Valid, invalid when there was no change. The test results were shown by the number of subjects who were valid or slightly valid.

[Keratin improvement (increased keratinocyte anti-peeling effect) effect test] Scotch cheap (Nichiban Mending Tape) was adhered to the skin of the test area before and after the start of the rough skin improvement effect test described above, and this was peeled off. The state of the keratinocytes attached to the tape is examined in detail using a scanning electron microscope.
The anti-exfoliation property of skin keratinocytes was analyzed according to the criteria in the table below, and the keratin improving effect was obtained.

[0017]

[Table 2]

The evaluation was made effective when the difference between the evaluation point of the test site and that of the control site after continuous application for 4 weeks was improved by 2 points or more, 1 case was slightly effective, and 0 point was invalid. . The judgment results are shown by the number of subjects who were valid and slightly valid.

[Countermeasurement test of stratum corneum] 5 wt% of dansyl chloride, a fluorescent dye, in white petrolatum
Make a mixed ointment and apply 2 to the skin of the forearm of 10 subjects.
A patch is applied for 4 hours, and dansyl chloride is permeated and bonded to the stratum corneum. After that, about 0.2 g of the test sample was applied to the same site twice a day (morning and evening), and once a day, the fluorescence of dansyl chloride was adjusted using an ultraviolet lamp in a dark place until the fluorescence disappeared. The number of days was defined as the turnover of the stratum corneum of the skin.

The measurement results are shown by the average value of the number of days of each subject. Normal turnover of stratum corneum is 13 ~
16 days or around 18 days in aged skin. On the other hand, when the anti-aging effect appears, it is shortened to around 13 days.

[Sensory test (Beautiful skin effect test)] Rough skin,
Female subject (35-55 years old) who complains of fine wrinkles, dry skin, etc.
The sample was applied to 10 people twice a day (morning and evening) for 4 consecutive weeks, and the effect after 4 weeks was evaluated. The test results were expressed by the number of people who answered that the skin was moistened, the skin became smooth, and the skin became taut for each item of skin wettability, smoothness, and elasticity.

Examples 1 to 9 and Comparative Example 1 [Skin lotion] The skin lotion having the composition shown in Table 3 was mixed with the organic acid salt of nicotinic alcohol as shown in Table 4, and each skin lotion was prepared by the following preparation method. Was prepared.

[0023]

[Table 3]

[Preparation Method] The organic acid salt of nicotinic alcohol as the component C is blended with the component B to uniformly dissolve the components A and B, and then the components A and B are mixed and dispersed by stirring, and then the container. To fill. At the time of use, the contents are shaken and dispersed evenly before use.

The results of carrying out the various tests are shown in Table 4.

[0026]

[Table 4]

The skin lotions containing the organic acid salt of nicotinic alcohol of Examples 1 to 9 were found to have good results in various tests as compared with Comparative Example 1.

Examples 10 to 18 and Comparative Example 2 [Skin Cream] Each skin cream was prepared by blending organic acid salts of various nicotinic alcohols as shown in Table 6 with the composition shown in Table 5 by the following preparation method. Prepared.

[0029]

[Table 5]

[Preparation Method] The organic acid salt of nicotinic alcohol as the component C is blended with the component B, and each of the components A and B is 8
Each skin cream was prepared by heating and dissolving at 0 ° C., then mixing and stirring, and cooling to 30 ° C.

The results of various tests are shown in Table 6.

[0032]

[Table 6]

As shown in Table 6, it was clear that the skin creams of Examples 9 to 18, which were the skin cosmetics of the present invention, were superior to Comparative Example 2 in all properties. .

[0034]

INDUSTRIAL APPLICABILITY As described above, the present invention provides a skin cosmetic excellent in the effect of preventing skin aging (effect of improving rough skin, effect of improving keratin, effect of accelerating turnover of the stratum corneum, effect of beautiful skin, etc.). be able to.

[Procedure amendment]

[Submission date] May 17, 1995

[Procedure Amendment 1]

[Document name to be amended] Statement

[Name of item to be corrected] 0023

[Correction method] Change

[Correction content]

[0023]

[Table 3]

[Procedure Amendment 2]

[Document name to be amended] Statement

[Name of item to be corrected] 0029

[Correction method] Change

[Correction content]

[0029]

[Table 5]

Claims (1)

[Claims] 1. Malic acid, citric acid, succinic acid, lactic acid,
A skin cosmetic, comprising a salt of nicotinic alcohol and one or more organic acids selected from the group consisting of glycolic acid, fumaric acid and maleic acid.