JPH0543448A - Cosmetic for preventing skin from aging - Google Patents

Abstract

PURPOSE:To obtain a quick-acting cosmetic, capable of sustaining excellent preventive effects on skin aging and useful for preventing the skin from aging by using gamma-aminobutyric acid and diisopropylamine dichloroacetate in combination. CONSTITUTION:A cosmetic for preventing the skin from aging is obtained by blending gamma-aminobutyric acid which is an amino acid-based skin activator with diisopropylamine dichloroacetate. The cosmetic is capable of exhibiting remarkable effects as follows: synergistic action on the skin, dilation of skin peripheral blood vessels, increase in skin function, prevention of skin wrinkling change into delicate and moist skin, simultaneous production and sustaining of preventive effects on skin aging in a short time, etc.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin anti-aging cosmetic composition (a skin cosmetic composition used to prevent skin aging), and more specifically to a skin anti-aging effect (rough skin improving effect, keratin improving effect, turnover speed). Skin cosmetics having an excellent effect of speeding up the skin, an effect of beautiful skin, etc.).

[0002]

2. Description of the Related Art Aged skin is dry and non-smooth rough skin in which keratinocyte exfoliation phenomenon is observed. Aged skin generally has a slow turnover speed, and it is said that the turnover speed is increased by imparting an antiaging effect to the skin.

The Applicant previously noted that vitamin E nicotinate, vitamin E orotate, and γ-
Aminobutyric acid compounds have been found to have the effect of promoting skin function by the peripheral vasodilatory effect of skin and preventing aging, and have already proposed (Japanese Patent Publication No. 48-43868).
Japanese Patent Publication No. 52-2979 and Japanese Patent Publication No. 58-26726
Publication). Further, it was found that diisopropylamine dichloroacetate enhances the skin function by the skin tissue activating action, and similarly has the effect of preventing skin aging (Japanese Patent Application Laid-Open No. 53-136528).

However, any of the skin cosmetics prepared by separately adding the skin activating agent, which is a component for enhancing the skin function, has a delayed effect of preventing aging and the like, and in the case of cream, for example, after 6 months. In the case of lotion, the effect appeared after 3 months, which was not completely satisfactory, and there was room for improvement.

The inventors of the present invention have conducted extensive studies as an amelioration of this difficulty, and as a result, when γ-aminobutyric acid and diisopropylamine dichloroacetate were blended, the synergistic effect of both of them caused an excellent effect of preventing skin aging (rough skin). The effect of improving the effect of improving keratin and keratin and increasing the turnover speed) are exhibited in a very short period of 1 to 2 months after the start of use, and a sustained-acting anti-aging skin cosmetic composition is obtained. Heading, completed the present invention.

[0006]

The present invention is a skin anti-aging cosmetic composition containing γ-aminobutyric acid and diisopropylamine dichloroacetate.

The γ-aminobutyric acid and diisopropylamine dichloroacetate according to the present invention are known compounds, and each of them is described in detail in the above publication.

The γ-aminobutyric acid in the skin anti-aging cosmetic composition of the present invention is an amino acid type skin activator,
It is a water-soluble skin activating agent together with diisopropylamine dichloroacetate. It is mixed with a skin cosmetic base such as lotion, emulsion or cream as an aqueous phase component and adjusted by emulsification, mixing, dispersion dissolution, solubilization, etc. To be done.

That is, both skin activating agents act synergistically on the skin to expand the peripheral blood vessels of the skin, enhance the skin function, prevent wrinkles of the skin, fine texture, and In addition to making the skin moisturized (skin beautifying effect), it also exerts outstanding effects such as excellent anti-aging effect on skin (excellent effect on rough skin and keratin improvement, effect of accelerating turnover speed) in a short period of time Can be played. At this time, the compounding amount of diisopropylamine dichloroacetate is 0.1 to 0.1 based on the total amount of the cosmetic (composition).
It is 2% by weight (hereinafter abbreviated as wt%). Also, γ
-The compounding amount of aminobutyric acid is 0.05 to 1 wt% based on the total amount of cosmetics. Even if the blending amount of each of these exceeds the upper limit of the above range, an effect commensurate with the blending amount exceeding the above range cannot be expected, and if the blending amount is less than the lower limit, the object of the present invention cannot be achieved. The ratio of the blending amount (weight) of diisopropylamine dichloroacetate and γ-aminobutyric acid is preferably 1: 0.2 to 1.0.

In addition to the above, the skin cosmetic of the present invention may be appropriately blended with a dye, a fragrance, an antiseptic, a surfactant, a pigment, an antioxidant, etc. within the range to achieve the object of the present invention. You can

[0011]

EXAMPLES Examples will be described below. In addition, the turnover speed measuring method of the stratum corneum, the measuring test method of the rough skin improving effect, the measuring test method of the corneous improving effect, and the sensory test described in Examples are as follows.

(1) Method for measuring turnover rate of stratum corneum A fluorescent dye, dansyl chloride, was added to white vaseline in an amount of 5 w.
Make an ointment containing t% and apply it to the skin of the subject's forearm.
Apply occluded for a while and permeate dansyl chloride into the stratum corneum. Thereafter, the test sample was applied to the same site twice a day (morning and evening), and the fluorescence of dansyl chloride was examined every day. The number of days until the fluorescence disappeared was defined as the turnover rate of the stratum corneum of the skin. The normal turnover rate of the stratum corneum of the skin is 14 to 16 days, but in aged skin it extends to around 18 days, and when the antiaging effect appears, it is shortened to around 12 days.

(2) Test method for measuring rough skin improving effect The effect of continuous application for 4 weeks was investigated for 20 middle-aged and elderly subjects having rough skin on the lower legs. About 1 g of the sample was applied to the left lower leg test site of the test subject twice a day, and the condition of the skin before and after the start of the test was evaluated according to the following criteria. The lower right leg was not coated with the sample and served as a control. [Criteria for skin dryness] −: Normal ±: Minor dryness, no desquamation +: Dryness, mild desquamation ++: Dry, moderate desquamation ++: Dryness, remarkable desquamation Compare the test results before and after the test with the control site However, when the skin dryness is improved by two or more stages (for example, + → −,
++ → ±) is defined as “valid”, a case of improvement by 1 level is defined as “slightly valid”, and a case of no change is defined as “invalid”. The test results are shown by the number of subjects who were “effective” and “somewhat effective”.

(3) Measurement test method for keratin improvement (increased anti-peeling property of keratinocytes) Scotch tape (Nichiban Mending Tape) is adhered to the skin of the test area before and after the start of the rough skin improvement measurement test described above, The state of the keratinocytes attached to the tape when peeled off was examined in detail by a scanning electron microscope, and the skin keratinocyte anti-peeling property was separated according to the following criteria, and the keratin improving effect was obtained. [Criteria for keratin improving effect (increased keratinocyte anti-exfoliation)] Evaluation point 1: No scale 〃 2: Small scale dotted 〃 3: Small to medium scale remarkable 〃 4: Large scale remarkable 4 consecutive weeks of judgment When the difference between the evaluation point of the test site after application and that of the control site was 2 points or more, "effective" was given, 1 point was "somewhat effective", and 0 point was "ineffective". The test results are shown by the number of subjects who were “valid” and “somewhat valid”.

(4) Sensory test (Beautiful skin effect test) Female subjects (35-35) who complain of rough skin, fine wrinkles, dry skin, etc.
The sample was applied to 20 people (55 years old) twice a day (morning and evening) for 3 consecutive months, and the effect after 1, 2 and 3 months was evaluated. The test results replied that "the skin was moisturized", "the skin was smooth", and "the skin was taut" with respect to each item of skin wettability, smoothness, and elasticity. The number of people is shown.

Examples 1 to 4 and Comparative Examples 1 to 4 [Skin cream] γ-aminobutyric acid (hereinafter abbreviated as GABA) and diisopropylamine dichloroacetate (hereinafter abbreviated as DADA) were blended as shown in Table 1. ,
Each skin cream was prepared with the following composition, and the above-mentioned tests were carried out. (1) Composition

[0017]

[Table 1]

(2) Preparation Method Each of the components (A) and (B) was heated and dissolved at 80 ° C., then mixed and cooled to 30 ° C. with stirring to prepare each skin cream. (3) Properties Table 2 shows the results of various tests of each skin cream. As shown in Table 2, the skin creams of Comparative Examples 1 to 4 in which only DADA or GABA was blended alone did not provide sufficient effects in various characteristics, and thus the skin creams of Examples 1 to 1 of the present invention were obtained.
The skin cream containing DADA and GABA as shown in 4 showed remarkable effects in various properties, and a sensory test showed an excellent skin-beautifying effect 1-2 months after application of the sample.

[Table 2]

Examples 5-8, Comparative Examples 5-8 [two-layer type skin lotion] As in Example 1, Table 3
Each two-layer type skin lotion was prepared in the above composition and various tests were carried out. The results are shown in Table 4. (1) Composition

[0020]

[Table 3]

(2) Preparation Method After uniformly dissolving each of (A) and (B), the components (A) and (B) are mixed and dispersed by stirring, and then filled in a container. At the time of use, the contents should be evenly dispersed by shaking. (3) Properties As shown in Table 4, in Comparative Examples 5 to 8, Examples 5 to 8 which are the skin anti-aging cosmetics of the present invention all show good results in various tests, and the beautiful skin in the sensory test is shown. The effect is also exhibited in a very short period of time.

[Table 4]

[0022]

EFFECTS OF THE INVENTION As described above, the present invention provides a skin anti-aging cosmetic composition which is excellent in rough skin improving effect, keratin improving effect, and quick turnover speed effect, and also has a remarkable skin beautiful effect. it is obvious.

Claims (1)

[Claims] 1. A cosmetic for preventing skin aging, which comprises γ-aminobutyric acid and diisopropylamine dichloroacetate.