JPH07509255A - シグマレセプター及びｄ↓２レセプター親和性を有する４−（４−フルオロフェニルメチル）−ピペリジン - Google Patents

シグマレセプター及びｄ↓２レセプター親和性を有する４−（４−フルオロフェニルメチル）−ピペリジン

Info

Publication number
JPH07509255A
JPH07509255A JP6524990A JP52499094A JPH07509255A JP H07509255 A JPH07509255 A JP H07509255A JP 6524990 A JP6524990 A JP 6524990A JP 52499094 A JP52499094 A JP 52499094A JP H07509255 A JPH07509255 A JP H07509255A
Authority
JP
Japan
Prior art keywords
compound
general formula
receptor
piperidine
fluorophenoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6524990A
Other languages
English (en)
Japanese (ja)
Inventor
フォケット，ラファエル
ボロス，ジョルディ
サクリスタン，アウレリオ
オルティツ，ホセ
Original Assignee
フエルレル インターナショナル，ソシエダッド アノニマ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by フエルレル インターナショナル，ソシエダッド アノニマ filed Critical フエルレル インターナショナル，ソシエダッド アノニマ
Publication of JPH07509255A publication Critical patent/JPH07509255A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP6524990A 1993-05-18 1994-05-17 シグマレセプター及びｄ↓２レセプター親和性を有する４−（４−フルオロフェニルメチル）−ピペリジン Pending JPH07509255A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES09301062A ES2066721B1 (es) 1993-05-18 1993-05-18 Nuevos compuestos derivados de la piridina 1,4-disustituida.
ES9301062 1993-05-18
PCT/EP1994/001594 WO1994026712A1 (en) 1993-05-18 1994-05-17 4-(4-fluorophenylmethyl)-piperidines having sigma and d2-receptor affinity

Publications (1)

Publication Number Publication Date
JPH07509255A true JPH07509255A (ja) 1995-10-12

Family

ID=8281846

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6524990A Pending JPH07509255A (ja) 1993-05-18 1994-05-17 シグマレセプター及びｄ↓２レセプター親和性を有する４−（４−フルオロフェニルメチル）−ピペリジン

Country Status (12)

Country Link
EP (1) EP0651744A1 (no)
JP (1) JPH07509255A (no)
KR (1) KR950702535A (no)
AU (1) AU675332B2 (no)
CA (1) CA2140260A1 (no)
ES (1) ES2066721B1 (no)
FI (1) FI950197A0 (no)
NO (1) NO301638B1 (no)
NZ (1) NZ267100A (no)
TW (1) TW252975B (no)
WO (1) WO1994026712A1 (no)
ZA (1) ZA943036B (no)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1999000149A (es) 1998-09-09 2000-01-12 Pfizer Prod Inc Derivados de 4,4-biarilpiperidina

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3576810A (en) * 1968-06-20 1971-04-27 Robins Co Inc A H 1-substituted-3-(-4)-aroylpiperidines
SE7409245L (no) * 1973-07-19 1975-01-20 Robins Co Inc A H
US3956296A (en) * 1974-12-11 1976-05-11 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
DK623586A (da) * 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
FR2681319B1 (fr) * 1991-09-12 1995-02-17 Synthelabo Derives de 1-(phenoxyalkyl)piperidine, leur preparation et leur application en therapeutique.
ES2060547B1 (es) * 1992-06-04 1995-06-16 Ferrer Int Mejoras en el objeto de la patente de invencion n/ 9201158 que se refiere a "procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina".

Also Published As

Publication number Publication date
NO301638B1 (no) 1997-11-24
ES2066721B1 (es) 1996-02-16
ZA943036B (en) 1995-05-02
FI950197A (fi) 1995-01-17
AU6928494A (en) 1994-12-12
CA2140260A1 (en) 1994-11-24
AU675332B2 (en) 1997-01-30
NO950062L (no) 1995-01-06
KR950702535A (ko) 1995-07-29
WO1994026712A1 (en) 1994-11-24
EP0651744A1 (en) 1995-05-10
ES2066721A1 (es) 1995-03-01
FI950197A0 (fi) 1995-01-17
TW252975B (no) 1995-08-01
NZ267100A (en) 1996-09-25
NO950062D0 (no) 1995-01-06

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