JPH07505388A - 抗原生動物及び抗寄生虫活性を有する１，４−ナフトキノン誘導体 - Google Patents

抗原生動物及び抗寄生虫活性を有する１，４−ナフトキノン誘導体

Info

Publication number
JPH07505388A
JPH07505388A JP5517264A JP51726493A JPH07505388A JP H07505388 A JPH07505388 A JP H07505388A JP 5517264 A JP5517264 A JP 5517264A JP 51726493 A JP51726493 A JP 51726493A JP H07505388 A JPH07505388 A JP H07505388A
Authority
JP
Japan
Prior art keywords
group
compound
formula
alkyl
tables
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5517264A
Other languages
English (en)
Japanese (ja)
Inventor
ハドソン、アラン・トーマス
イーテス、クライブ・レオナルド
Original Assignee
ザ・ウエルカム・ファウンデーション・リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ・ウエルカム・ファウンデーション・リミテッド filed Critical ザ・ウエルカム・ファウンデーション・リミテッド
Publication of JPH07505388A publication Critical patent/JPH07505388A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/32—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C271/34—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP5517264A 1992-04-06 1993-04-05 抗原生動物及び抗寄生虫活性を有する１，４−ナフトキノン誘導体 Pending JPH07505388A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB929207517A GB9207517D0 (en) 1992-04-06 1992-04-06 Heterocyclic compounds
GB9207517.5 1992-04-06
PCT/GB1993/000708 WO1993020044A1 (en) 1992-04-06 1993-04-05 1,4 naphthoquinone derivtives with anti-protozoal and anti-parasitic activity

Publications (1)

Publication Number Publication Date
JPH07505388A true JPH07505388A (ja) 1995-06-15

Family

ID=10713546

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5517264A Pending JPH07505388A (ja) 1992-04-06 1993-04-05 抗原生動物及び抗寄生虫活性を有する１，４−ナフトキノン誘導体

Country Status (16)

Country Link
EP (1) EP0634996A1 (es)
JP (1) JPH07505388A (es)
KR (1) KR950700874A (es)
CN (1) CN1083048A (es)
AU (1) AU3899293A (es)
CA (1) CA2133744A1 (es)
CZ (1) CZ242994A3 (es)
FI (1) FI944657A (es)
GB (1) GB9207517D0 (es)
HU (1) HUT68937A (es)
IL (1) IL105322A0 (es)
MX (1) MX9301962A (es)
NO (1) NO943737L (es)
SK (1) SK120994A3 (es)
WO (1) WO1993020044A1 (es)
ZA (1) ZA932458B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9169232B2 (en) * 2011-09-16 2015-10-27 Alkem Laboratories Limited 3-(5-methyl-2-oxo-l, 3-dioxol-4-yl) methyloxy-2-trans-[(4-chloro phenyl) cyclohexyl][1,4]naphthaquinone-atovaquone prodrug
KR20190020774A (ko) 2016-06-20 2019-03-04 더 스크립스 리서치 인스티튜트 항말라리아 조성물 및 이의 용도

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485116A (en) * 1981-10-16 1984-11-27 Hudson Alan T Antiprotozoal compounds
GB8310141D0 (en) * 1983-04-14 1983-05-18 Wellcome Found Naphthoquinone derivatives
AU633836B2 (en) * 1988-08-16 1993-02-11 Wellcome Foundation Limited, The Medicaments

Also Published As

Publication number Publication date
HU9402850D0 (en) 1995-01-30
GB9207517D0 (en) 1992-05-20
FI944657A0 (fi) 1994-10-05
ZA932458B (en) 1994-10-05
IL105322A0 (en) 1993-08-18
KR950700874A (ko) 1995-02-20
CA2133744A1 (en) 1993-10-14
NO943737D0 (no) 1994-10-05
EP0634996A1 (en) 1995-01-25
WO1993020044A1 (en) 1993-10-14
NO943737L (no) 1994-11-29
AU3899293A (en) 1993-11-08
SK120994A3 (en) 1995-07-11
CZ242994A3 (en) 1995-06-14
HUT68937A (en) 1995-08-28
MX9301962A (es) 1993-11-01
CN1083048A (zh) 1994-03-02
FI944657A (fi) 1994-12-02

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