JPH07502987A - サイトカインおよび抗原を用いた全身の免疫応答の調節 - Google Patents
サイトカインおよび抗原を用いた全身の免疫応答の調節Info
- Publication number
- JPH07502987A JPH07502987A JP5507110A JP50711093A JPH07502987A JP H07502987 A JPH07502987 A JP H07502987A JP 5507110 A JP5507110 A JP 5507110A JP 50711093 A JP50711093 A JP 50711093A JP H07502987 A JPH07502987 A JP H07502987A
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- cells
- cytokine
- tumor
- immune response
- mammal
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.抗原に対する哺乳動物の免疫反応を調節する方法であって;個々の動物に a)抗原;および b)上記抗原に対する哺乳動物の免疫反応を変化させる、少なくとも1つのサイ トカイン、接着または補助分子; の治療上の有効量を、上記抗原に対する哺乳動物の全身的な免疫反応の調節が達 成されるような方法で同時に投与することからなる方法。 2.腫瘍細胞タイプに対する哺乳動物の免疫反応を調節する方法であって:哺乳 動物に a)抗原であって、該抗原は腫瘍細胞自体あるいは該腫瘍細胞からの抗原である もの;および b)上記抗原に対する哺乳動物の免疫反応を変化させる、少なくとも1つのサイ トカイン; の治療上の有効量を、上記腫癌細胞タイプに対する哺乳動物の全身的な免疫反応 の調節が達成されるような方法で同時に投与することからなる方法。 3.抗原に対する哺乳動物の免疫反応を調節する方法であって:哺乳動物に少な くとも a)サイトカイン;および b)上記抗原; の組み合わせを発現するような方法で修飾された細胞を投与することからなり、 該修飾された細胞の治療上の有効量を、上記抗原に対する哺乳動物の全身的な免 疫反応の調節が達成されるような方法で投与することからなる方法。 4.腫瘍細胞タイプに対する哺乳動物の免疫反応を調節する方法であって:哺乳 動物に、少なくとも a)第1のサイトカイン;および b)第2のサイトカイン; の組み合わせを発現するような方法で修飾された腫瘍細胞を投与することからな り、該修飾された腫瘍細胞の治療上の有効量を、上記腫瘍細胞タイプに対する哺 乳動物の全身的な免疫反応の調節が達成されるような方法で投与することからな る方法。 5.第1のサイトカインがインターロイキン−2で、上記第2のサイトカインが 顆粒球−マクロファージコロニー刺激因子である請求項4の方法。 6.腫瘍細胞タイプが黒色腫細胞タイプである請求項5の方法。 7.腫瘍細胞タイプに対する哺乳動物の免疫反応を調節する方法であって:a) 上記腫瘍細胞タイプの腫瘍細胞であって、少なくとも1つのサイトカインを発現 する腫瘍細胞を提供し; b)上記細胞を照射し; c)上記細胞を上記哺乳動物に投与する;ことからなり、該細胞の治療上の有効 量を、上記腫瘍細胞タイプに対する哺乳動物の全身的な免疫反応の調節が達成さ れるような方法で投与することからなる方法。8.上記照射された腫瘍細胞が顆 粒球−マクロファージコロニー刺激因子を発現する請求項7の方法。 9.上記照射された修飾された腫瘍細胞が、IL−4、IL−6、CD2および ICAMからなる群から選択されるサイトカインを発現する請求項7の方法。 10.哺乳動物の特定タイプの継代腫瘍を逆戻りさせる方法であって:哺乳動物 に a)上記腫瘍タイプの腫瘍細胞;およびb)少なくとも1つのサイトカイン; の治療上の有効量を、上記腫瘍細胞タイプに対する哺乳動物の全身的な免疫反応 の調節が達成されるような方法で同時に投与することからなる方法。 11.哺乳動物の特定タイプの継代腫瘍を逆戻りさせる方法であって:哺乳動物 に、少なくとも a)第1のサイトカイン:および b)第2のサイトカイン: の組み合わせを発現するように修飾された腫瘍細胞を投与することからなり、該 修飾された腫瘍細胞の治療上の有効量を、上記腫瘍細胞タイプに対する哺乳動物 の全身的な免疫反応の調節が達成されるような方法で投与し、該調節された免疫 反応は上記継代腫瘍の逆戻りによるものである方法。 12.上記修飾された腫瘍細胞がさらに第3のサイトカインを発現する請求項1 1の方法。 13.第1のサイトカインがIL−2で、第2のサイトカインがGM−CSFで 、第3のサイトカインがTNF−αである請求項11の方法。 14.第1のサイトカインがIL−2で、第2のサイトカインがGM−CSFで 、第3のサイトカインがTNF−α、IL−4、CD2およびICAMからなる 群から選択される請求項11の方法。 15.哺乳動物の特定タイプの継代腫瘍を逆戻りさせる方法であって:a)上記 腫瘍細胞タイプの腫瘍細胞であって、少なくとも1つのサイトカインを発現する 腫瘍細胞を提供し; b)上記細胞を照射し: c)上記細胞を上記哺乳動物に投与する:ことからなり、該細胞の治療上の有効 量を、上記腫瘍細胞タイプに対する哺乳動物の全身的な免疫反応の調節が達成さ れるような方法で投与することからなる方法。 16.サイトカインをコードしている遺伝物質を組み込まれており、該遺伝物質 によってコードされたサイトカインのインビボでの発現が可能であり、上記遺伝 物質は、MFG,α−SCG、pLJおよびpEmからなる群から選択されるレ トロウイルスベクターの遺伝物質ならびにサイトカインをコードする遺伝物質か らなる請求項3の修飾された細胞。 17.サイトカインをコードしている遺伝物質を組み込まれており、該遺伝物質 によってコードされたサイトカインのインビボでの発現が可能であり、上記遺伝 物質は、MFG,α−SCG、pLJおよびpEmからなる群から選択されるレ トロウイルスベクターの遺伝物質ならびにサイトカインをコードする遺伝物質か らなる請求項4の修飾された細胞。 18.サイトカインをコードしている遺伝物質を組み込まれており、該遺伝物質 によってコードされたサイトカインのインビボでの発現が可能であり、上記遺伝 物質は、MFG,α−SCG、pLJおよびpEmからなる群から選択されるレ トロウイルスベクターの遺伝物質ならびにサイトカインをコードする遺伝物質か らなる請求項7の修飾された細胞。 19.サイトカインをコードしている遺伝物質を組み込まれており、該遺伝物質 によってコードされたサイトカインのインビボでの発現が可能であり、上記遺伝 物質は、MFG,α−SCG、pLJおよびpEmからなる群から選択されるレ トロウイルスベクターの遺伝物質ならびにサイトカインをコードする遺伝物質か らなる請求項11修飾された細胞。
Applications Claiming Priority (3)
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US77119491A | 1991-10-04 | 1991-10-04 | |
US771,194 | 1991-10-04 | ||
PCT/US1992/008455 WO1993006867A1 (en) | 1991-10-04 | 1992-10-05 | The regulation of systemic immune responses utilizing cytokines and antigens |
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Publication Number | Publication Date |
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JPH07502987A true JPH07502987A (ja) | 1995-03-30 |
JP3580371B2 JP3580371B2 (ja) | 2004-10-20 |
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JP50711093A Expired - Lifetime JP3580371B2 (ja) | 1991-10-04 | 1992-10-05 | サイトカインおよび抗原を用いた全身の免疫応答の調節 |
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EP (2) | EP1216710B1 (ja) |
JP (1) | JP3580371B2 (ja) |
AT (2) | ATE230615T1 (ja) |
AU (1) | AU677165B2 (ja) |
CA (1) | CA2120503C (ja) |
DE (2) | DE69232890T2 (ja) |
ES (1) | ES2189788T3 (ja) |
WO (1) | WO1993006867A1 (ja) |
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US5662896A (en) * | 1988-03-21 | 1997-09-02 | Chiron Viagene, Inc. | Compositions and methods for cancer immunotherapy |
US5902576A (en) * | 1992-10-22 | 1999-05-11 | Yeda Research And Development Co. Ltd. At Weizmann Institute Of Science | Antitumor pharmaceutical composition comprising IL-6 transfected cells |
FR2710536B1 (fr) * | 1993-09-29 | 1995-12-22 | Transgene Sa | Usage anti-cancéreux d'un vecteur viral comportant un gène modulateur de la réponse immunitaire et/ou inflammatoire. |
CA2178902A1 (en) * | 1993-12-14 | 1995-06-22 | Drew Pardoll | Controlled release of pharmaceutically active substances for immunotherapy |
US5478556A (en) * | 1994-02-28 | 1995-12-26 | Elliott; Robert L. | Vaccination of cancer patients using tumor-associated antigens mixed with interleukin-2 and granulocyte-macrophage colony stimulating factor |
FR2725726B1 (fr) * | 1994-10-17 | 1997-01-03 | Centre Nat Rech Scient | Vecteurs viraux et utilisation en therapie genique |
WO1996021015A2 (en) * | 1994-12-30 | 1996-07-11 | Chiron Corporation | Combination gene delivery vehicles |
US6372208B1 (en) | 1999-09-28 | 2002-04-16 | The Trustees Of The University Of Pennsylvania | Method of reducing an immune response to a recombinant virus |
US6251957B1 (en) | 1995-02-24 | 2001-06-26 | Trustees Of The University Of Pennsylvania | Method of reducing an immune response to a recombinant virus |
AU6282896A (en) * | 1995-06-19 | 1997-01-15 | University Of Medicine And Dentistry Of New Jersey | Gene therapy of solid tumors with interferons alone or with other immuno-effector proteins |
US5837231A (en) * | 1996-06-27 | 1998-11-17 | Regents Of The University Of Minnesota | GM-CSF administration for the treatment and prevention of recurrence of brain tumors |
AU3889997A (en) | 1996-08-16 | 1998-03-06 | Johns Hopkins University School Of Medicine, The | Melanoma cell lines expressing shared immunodominant melanoma antigens nd methods of using same |
EP0834323A1 (en) * | 1996-09-30 | 1998-04-08 | Introgene B.V. | Cytokine gene therapy for treatment of malignacies |
GB9827104D0 (en) * | 1998-12-10 | 1999-02-03 | Onyvax Ltd | New cancer treatments |
JP2006507214A (ja) * | 2002-02-22 | 2006-03-02 | イントラセル・リソーシーズ・エル・エル・シー | 無菌の、免疫原性の、非腫瘍形成性の腫瘍細胞組成物及び方法 |
US7176022B2 (en) | 2002-12-20 | 2007-02-13 | Cell Genesys, Inc. | Directly injectable formulations which provide enhanced cryoprotection of cell products |
US20050019336A1 (en) | 2003-07-23 | 2005-01-27 | Dalgleish Angus George | Human prostate cell lines in cancer treatment |
ATE512668T1 (de) * | 2003-12-30 | 2011-07-15 | Mologen Ag | Allogenes tumortherapeutikum |
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EP0303687B1 (en) * | 1987-03-02 | 1992-11-11 | Genetics Institute, Inc. | Compositions for enhancing adcc therapy |
DE3922444A1 (de) * | 1988-03-01 | 1991-01-10 | Deutsches Krebsforsch | Virusmodifizierte tumorvakzine fuer die immuntherapie von tumormetastasen |
DE3806565A1 (de) * | 1988-03-01 | 1989-09-14 | Deutsches Krebsforsch | Virusmodifizierte tumorvakzinen fuer die immuntherapie von tumormetastasen |
JPH06501161A (ja) * | 1990-09-14 | 1994-02-10 | ザ ジョーンズ ホプキンス ユニバーシティー | 抗腫瘍免疫性の強化と遺伝子治療のための組成物及び方法 |
ATE163046T1 (de) * | 1990-10-31 | 1998-02-15 | Somatix Therapy Corp | Genetische veränderung von endothelzellen |
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ES2189788T3 (es) | 2003-07-16 |
DE69232890D1 (de) | 2003-02-13 |
EP1216710B1 (en) | 2006-04-05 |
ATE322286T1 (de) | 2006-04-15 |
EP1216710A1 (en) | 2002-06-26 |
DE69233614D1 (de) | 2006-05-18 |
JP3580371B2 (ja) | 2004-10-20 |
DE69233614T2 (de) | 2007-02-15 |
CA2120503C (en) | 2006-04-04 |
AU2777692A (en) | 1993-05-03 |
ATE230615T1 (de) | 2003-01-15 |
DE69232890T2 (de) | 2003-10-09 |
AU677165B2 (en) | 1997-04-17 |
EP0607309B1 (en) | 2003-01-08 |
CA2120503A1 (en) | 1993-04-15 |
WO1993006867A1 (en) | 1993-04-15 |
EP0607309A1 (en) | 1994-07-27 |
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