JPH07198665A - Chemical sensor plate - Google Patents

Abstract

PURPOSE:To prevent overflowing of liquid by covering an inlet part for liquid to be tested, and a reference liquid inlet part, excepting charge holes, by providing a partition wall on the outer upper surfaces of both parts between them, and by providing continuous overflow preventing walls respectively around both parts. CONSTITUTION:The upper parts of a reference liquid inlet part 12b and a inlet part 13b for liquid to be tested in an upper cell 11 are integrally coupled together so as to form a laterally long box-like shape. The lower surfaces thereof are opened, and a partition wall 14 is extended vertically and horizontally so as to divide the inside thereof. Inlet holes 12b-1, 13b-1 are formed in the upper surfaces thereof, and projected walls 12b-3, 13b-3 are formed on the opposite sides so as to prevent charged liquid from being diffused. Accordingly, the inlet parts 12b, 13b are covered, excepting the inlet holes 12b-1, 13b-1, and accordingly, overflowing of the liquid can be prevented. Further, an overflowing preventing wall 11d may be provided between the inlet parts 12b, 13b, and an overflowing wall 11d may be provided therearound, continuous with the former partition wall. With this arrangement, it is restrain the liquid from leaking outside.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a disposable simple chemical sensor plate used for a chemical sensor for inspecting blood or the like.

[0002]

2. Description of the Related Art As a disposable simple type chemical sensor plate for inspection, several chemical sensor plates have been conventionally proposed. As one of them, the chemical sensor plate previously proposed by the applicant of the present invention is, as shown in FIG.
A pair of reference electrodes 22a and a sample liquid measuring electrode 2 are provided on the substrate 21.
Two sets of 2b are provided as one set, and the circular portions of the opposite ends of the respective electrodes and the ends of the respective electrodes on the side away from each other are covered with the insulating film 23, and the former are covered with the windows 24a,
4b and the sensor plate body 2 with the latter as an external electrode
5a, and a pair of through holes 26a to 26e, which communicate with the window portions 24a and 24b of each group, and the electrode 2 of each group.
A bank 29a having through holes 28a and 28b communicating with the external electrodes 2a and 22b, respectively, is joined to the sensor plate body 25a with a double-sided adhesive tape.
An ion-sensitive film is formed on the silver chloride layer previously provided at the opposite ends of each pair of electrodes by dropping five different ion-sensitive resin solutions into the through holes 26a to 26e and drying the solution. An ion sensitive electrode is formed. The bonded body of the sensor plate body 25a and the bank 29a is fitted into the recesses 30a and 30b of the lower cell 30 made of a resin plate,
The upper cell 32 made of a resin material is joined to the lower cell 30. The upper cell 32 has the elongated holes 2 on the back surface of the resin plate.
6a to 26e, the flow passages 33 and 34 formed of concave grooves.
Are divided into two parts by partition walls, and a reference liquid introduction part 35 and a sample liquid introduction part 36 are provided at one end of each flow passage and air vent holes 37, 37 ... Corresponding to the external electrodes at the exposed ends of the electrode 22a and the sample liquid measuring electrode 22b, terminal insertion holes 38a and 38b for inserting terminals of a measuring device (not shown) are provided.

When the sensor plate having such a structure is used, the reference solution and the sample solution are injected into the reference solution input section 35 and the sample solution injection section 36 with a syringe or the like, and are supplied to the flow passages 33 and 34, respectively. The liquid is supplied to the respective ion-sensitive electrodes through the through holes 26a to 26e in the course of circulation. For example, a filter paper is provided at the tips of the flow passages 33 and 34 so that both liquids are liquid-junctioned in this state.
Then, in that state, the terminal of the measuring instrument is connected to the terminal insertion hole 38a,
The ion concentration of the sample liquid is measured by inserting it into the electrode 38b and bringing it into contact with the electrode, and a total of 5 different ion concentrations are measured for each electrode coated with different ion sensitive membranes of each set.

[0004]

However, in the above structure, since the upper surfaces of the reference liquid introducing section 35 and the sample liquid introducing section 36 are open, the measuring operation is performed after the sample solution and the reference solution are introduced respectively. At the time of or after the measurement, these liquids overflow due to light vibration, etc. and come into contact with the hands of the operator. If the sample liquid is blood, there is a risk of infection of the disease, and both liquids mix. As a result, a measurement error may occur, or if the measuring device is contaminated with the sample liquid, it may malfunction. Further, the chemical sensor plate is inserted into the measuring section of the measuring device for measurement, but the chemical sensor plate may be inserted in the front-back direction erroneously, and a device for preventing the erroneous insertion has been desired. In addition, after the reference solution and the sample solution are introduced into the reference solution introducing section 35 and the sample solution introducing section 36, respectively,
When it is desired to quickly circulate the flow passages 33 and 34, the operation of tilting the tips of these flow passages is performed. However, the operation was not stable, and this was the same in the operation of inserting the chemical sensor plate into the measuring section of the measuring device, extracting it from the measuring section, and the like.

A first object of the present invention is to provide a chemical sensor plate which is easy to handle. A second object of the present invention is to provide a chemical sensor plate in which liquid does not easily overflow to the outside. A third object of the present invention is to provide a chemical sensor plate that prevents incorrect mounting on a measuring device.

[0006]

In order to solve the above problems, the present invention provides at least one set of a sample liquid measuring electrode having a coating film of a chemosensitive film and a reference electrode on a substrate. A chemical sensor plate body, a closed flow passage for supplying a sample liquid to the sample liquid measurement electrode, and a closed flow passage for supplying a reference liquid to the reference electrode are formed on the substrate surface, respectively. It has at least an upper cell having a sample liquid charging part communicating with one end and a reference liquid charging part, and each of the sample liquid charging part and the reference liquid charging part excludes a charging hole for charging the sample liquid and the reference liquid, respectively. A covered chemical sensor plate. Further, the present invention provides a chemical sensor plate main body in which at least one pair of a sample liquid measurement electrode having a coating film of a chemical sensitive film and a reference electrode is provided on a substrate, and a sample liquid is supplied to the sample liquid measurement electrode. A closed flow passage for supplying and a closed flow passage for supplying the reference liquid to the reference electrode are formed on the surface of the substrate, respectively, and have a sample liquid introduction part and a reference liquid introduction part communicating with one end of each flow passage. At least an upper cell is provided, and a partition wall is provided between the sample liquid feeding part and the reference liquid feeding part on the outer upper surface thereof, and at least a part of the periphery of each of the sample liquid feeding part and the reference liquid feeding part. Provided is a chemical sensor plate in which a liquid overflow prevention wall continuous with the partition wall is provided. Further, the present invention provides a chemical sensor plate main body in which at least one pair of a sample liquid measurement electrode having a coating film of a chemical sensitive film and a reference electrode is provided on a substrate, and a sample liquid is supplied to the sample liquid measurement electrode. A closed flow passage for supplying and a closed flow passage for supplying the reference liquid to the reference electrode are formed on the surface of the substrate, respectively, and have a sample liquid introduction part and a reference liquid introduction part communicating with one end of each flow passage. There is provided a chemical sensor plate having at least an upper cell and having a shape for preventing erroneous mounting on a measuring device. Further, the present invention provides a chemical sensor plate main body in which at least one pair of a sample liquid measurement electrode having a coating film of a chemical sensitive film and a reference electrode is provided on a substrate, and a sample liquid is supplied to the sample liquid measurement electrode. A closed flow passage for supplying and a closed flow passage for supplying the reference liquid to the reference electrode are formed on the surface of the substrate, respectively, and have a sample liquid introduction part and a reference liquid introduction part communicating with one end of each flow passage. Provided is a chemical sensor plate which has at least an upper cell and has a gripping shape for a measurement operation in at least one of the sample liquid input part and the reference liquid input part.

[0007]

Since the sample liquid input part and the reference liquid input part are covered except for the input holes, and the partition wall and the liquid overflow prevention wall are provided on the outer upper surface of these input parts, the liquid overflow can be reduced. Further, the measuring device having the shape for preventing the incorrect mounting of the measuring device is not erroneously mounted. Further, since the shape for gripping the measurement operation is added, its handling operability is good.

[0008]

Embodiments of the present invention will now be described with reference to the drawings. Example 1 In FIG. 1, 1 is a multi-sensor plate body, and a pair of reference electrodes 2 is provided on a substrate 1a made of an epoxy composite material.
a, five sets of sample liquid measuring electrodes 2b are provided, and further an insulating film 3 made of a resin film such as an epoxy resin except for circular portions of opposite ends of the respective electrodes and end portions of the respective electrodes on the side away from each other. Are covered, and the former are windows 4a, 4b
And the latter is the external electrode. As for these electrodes, copper electrodes are plated with silver, and silver chloride layers are formed at the opposite ends of each pair of lower parts of the windows 4a and 4b. Reference numeral 5 denotes a bank formed of a polyester film or the like which is laminated on the main body of the multi-sensor plate, and has elongated slots 6a which correspond to and are continuous with the window portions 4a and 4b of the respective sets other than the above-mentioned set. 6d and the through holes 7a, 7 corresponding to the remaining set of windows 4a, 4b, respectively.
b is provided and the reference electrodes 2a, 2a are provided.
External electrode exposing holes 8a, 8a ... Are provided corresponding to the external electrodes of.
External electrode exposing holes 8b, 8b ... Are provided corresponding to the external electrodes b, 2b. The bank 5 is joined to the multi-sensor plate body 1 by a double-sided adhesive tape that is cut out so that the above holes are not blocked, and in that state, four kinds of ion-sensitive substances that are different from each of the elongated holes 6a to 6d. The ion-sensitive film is formed on the above-mentioned silver chloride layer by dropping a resin solution containing the above and drying, and each ion-sensitive electrode is completed. The electrodes of the silver chloride layer in the remaining set of windows 4a and 4b are left as they are and used for the measurement of a substance which does not require an ion sensitive film. Here, the double-sided adhesive tape is a tape in which an adhesive is applied to both sides of a plastic tape or a tape in which a base material such as a non-woven fabric is impregnated with the adhesive, and release paper is peeled off on the surface of the adhesive when not in use. However, it is a tape that can be peeled off from this release paper at the time of use so that other objects can be adhered to both sides. The adhesive may be a pressure-sensitive adhesive, a so-called hot melt type which is non-adhesive at room temperature but melts by heating, or a combination of both. This melting may be performed with the base plastic film itself. The joint body of the bank body 5 and the multi-sensor plate body 1 is fitted into the bank body 5 into the recess 9a and the recess 9b of the lower cell 9 made of a transparent material such as acrylic resin or styrene resin, and the multi-sensor plate 1 is fitted into the recess 9b. The upper surface of the bank and the lower cell are located on the same plane. Then, the lower cell 9 is joined to an upper cell 11 made of the same material as the lower cell via a double-sided adhesive tape 10 similar to the double-sided adhesive tape as described later, so that the bank body and the multi-sensor plate body are joined together. Interior of the bonded body. Here, as shown in FIG. 1, in the recess 9b of the lower cell 9, the bottom portion thereof, that is, the corresponding portion of the bottom surface of the lower cell, is opened at the center portion thereof, leaving the projecting pieces 9d, 9d on both front and rear sides. A square opening 9e is provided, and these projecting pieces 9e
The substrate 1a is placed on the d and 9d to support the bonded body of the bank body and the multi-sensor plate body. Also,
A notch 9f is provided at the tip of the lower cell so that the notch 9f is engaged with and coincides with a portion to be inserted when the lower cell is inserted into the measuring portion of the measuring device.

The upper cell 11 is, as shown in FIGS. 1 and 2, a concave groove communicating with the through holes 6a to 6e and 7a to 7e on the back surface of a transparent plate made of the same material as that of the lower cell. The reference liquid flow passage 12a and the sample liquid flow passage 13a are divided into two parts by a partition wall 14 whose lower surface is formed into a rough surface with a satin finish, and the reference liquid input part 1 is provided at one end of each flow passage.
2b, the sample liquid input part 13b is provided,
At the other end of each flow passage, air vent grooves 12c and 13c, which are narrow grooves and are in communication with the flow passage, are arranged in an L shape, and further, the sample liquid measuring electrode 2a and the reference electrode 2b of each set are provided. Terminal insertion holes 15a and 15b for inserting terminals of a measuring device (not shown) corresponding to the exposed ends, that is, the respective external electrodes, are provided so as to penetrate to the front surface side. The reference liquid input part 12b and the sample liquid input part 13b are
The upper part is integrally continuous and is formed in a horizontally long box shape protruding on the surface of the transparent plate, and the lower surface thereof is opened to divide the partition wall 14 in the length direction and the height direction to divide the inside into two. Charge holes 12b-1 and 1 are provided on the upper surface.
3b-1 is formed, and projecting walls 12b-3 and 13b-3 are provided inside the opposite sides of the respective injection holes so that diffusion of the injected liquid is hindered. . In addition, semi-cylindrical bulging portions are provided on the front walls of the reference liquid feeding portion 12b and the sample liquid feeding portion 13b, and the air vent groove 12c is provided in each of the vertical holes 12d and 13d.
13c are communicated with each other. Reference numerals 16a and 16b denote gripping protrusions provided on the upper ends of both sides of the outer surfaces of the reference liquid feeding portion 12b and the sample liquid feeding portion 13b. If both are held by fingers, the tip of the upper cell can be easily tilted, and will be described later. Insert the completed multi-sensor plate into the measuring device,
If it is used for gripping when it is taken out from it, its handling is easy. Further, a cutout portion 11b similar to the cutout portion 9f is provided at the tip of the transparent plate.

The double-sided adhesive tape 10 has penetrating frame portions 10a and 10b which are hollowed out in a rectangular shape at a central portion thereof, and a similar outer electrode penetrating frame portion 10b to the outside of each of them.
10b, and each of the former elongated holes 6a-6
External electrode exposing holes 8a, 8a ..., 8b, 8b ... Are made to face each of d, the through holes 7a, 7b, and the latter,
Moreover, the reference liquid flow passage 12a and the sample liquid flow passage 13a are connected to the former respectively, and the terminal insertion holes 15a and 15b of the respective sets are communicated to the latter respectively, and the reference liquid inlet 12b and the sample liquid inlet 13b are opened. No holes are formed in the parts and corresponding parts between them, and the surface is an adhesive tape. The double-sided adhesive tape 10 also has the cutout 9f and the cutout 11 described above.
A cutout portion 10c similar to that of b is provided.

17a to 17d, 18a to 18d, 19a
19d are upper cell 11 and double-sided adhesive tape 1 respectively
0, positioning protrusions, notches, and insertion holes provided in the lower cell 9 for positioning when these are assembled.

When the above-mentioned members are assembled in such a configuration, the upper cell 11 is joined to the lower cell 9 by the double-sided adhesive tape 10 at each peripheral portion, and
Bonded between each of the elongated holes 6a to 6d of the bank 5 and between the through holes 7a and 7b and the plate surface of the extension thereof, whereby the openings of the reference liquid input part 12b and the sample liquid input part 13b are double-sided bonded. The tape 10 is closed by the surface of the tape 10 to store the liquid, and the openings of the reference liquid flow passage 12a and the sample liquid flow passage 13a have ion openings of the bank 5 and the multi-sensor plate body 5 below the through hole. The membrane is closed to form the respective closed flow passages, and the air vent grooves 12c and 13c are further formed.
The opening is also closed by the double-sided adhesive tape 10, a continuous hole communicating with the closed flow passage is formed, and its tip communicates with the vertical holes 12d and 13d to form an air vent hole. On the other hand, the terminal insertion holes 15a and 15b of each set communicate with the external electrodes of the reference electrodes 2a, 2a ... Of the multi-sensor plate body 1 and the external electrodes of the sample liquid measurement electrodes 2b, 2b. It comes into contact with these external electrodes. Then, the lower cell 9, the double-sided adhesive tape 10 and the upper cell 11 are overlapped with each other so that the respective cutouts 9
The f, 10c, and 11b are also overlapped to form a cutout portion formed by the whole.

When the multi-sensor plate is used, the reference solution and the sample solution are injected into the reference solution input section 12b and the sample solution input section 13b by a syringe or the like, and the gripping projections 16a and 16b are held and tilted. , Flow passage 12
a, 13a, and each of the liquids are quickly circulated in the closed circulation part formed by the bank 5, etc., and the respective liquids are ion-sensitized to the respective window parts 4a, 4b through the elongated holes and the through holes. Flow path 12
a and 13a separating the partition wall 14 and the double-sided adhesive tape 10
The sample liquid and the reference liquid come into contact with each other by the capillary phenomenon or the like to penetrate into the microscopic voids formed particularly in the former part of the joint part or between the double-sided adhesive tape and the levee body 5, so that electrical conduction can be established. When inserted into the inserted portion of the measuring device in this state, the notch engages with a predetermined position, indicating that the insertion is correct. Then, connect the terminals of the measuring device to the respective terminal insertion holes 15a,
The concentration of different ions contained in the sample solution is measured by inserting the sample solution into the electrode 15b and bringing it into contact with the electrode, and a total of five kinds of ionic components are measured by one operation of introducing the sample solution and the reference solution. After the measurement, hold the protrusions 16a and 16b for gripping and pull out. In this series of operations, even if some vibration or the like is applied to the multi-sensor plate, the reference liquid and the sample liquid do not flow out because the injection holes are small.

In the above embodiment, only the charging holes are formed on the upper surfaces of the reference liquid charging portion and the sample liquid charging portion.
As shown in FIG. 3, the same reference numerals as 2 indicate the same components.
An overflow preventing partition wall 11c is provided between the charging portions, and the overflow preventing partition wall 1c is provided at the entire front end edges of the charging portions and toward the rear end side of both side edges, and further in the middle portion of the rear end edge.
You may provide the overflow prevention wall 11d continuous with 1c. With this configuration, even if the liquid flows out from the charging hole, it is difficult for the liquid to leak to the outside.

In the above, the notch is provided to prevent erroneous mounting, but the protrusion is provided on the contrary, and the predetermined portion of the inserted portion of the measuring portion of the measuring device is made into the concave portion for engaging with this. Is also good.

[0016]

As described above, according to the present invention, the reference liquid feeding portion and the sample liquid feeding portion are covered except the feeding holes, so that the respective liquids hardly overflow. Further, if a partition wall or an overflow preventing wall is provided on the upper surface of each of the charging parts, it becomes more difficult for the chemical sensor plate to overflow to the outside, and the handling becomes easy. In addition, since a malfunction preventing shape such as a notch that engages with a predetermined portion of the inserted portion of the measuring device is provided, erroneous mounting thereof is prevented, and a gripping shape for handling operation is provided. Easy to operate. In this way, a chemical sensor plate with good operability can be provided.

[Brief description of drawings]

FIG. 1 is an exploded perspective view of a multi-sensor plate according to a first embodiment of the present invention.

FIG. 2 is a perspective view of the upper cell viewed from the back side.

FIG. 3 is a perspective view of an upper cell of a multi-sensor plate according to a second embodiment of the present invention.

FIG. 4 is an exploded perspective view of a multi-sensor plate mainly composed of those proposed in the previous application.

[Explanation of symbols]

 1 Multi-sensor plate main body 2a Reference liquid measurement electrode 2b Sample liquid measurement electrode 5 Bank 9 Lower cell 11 Upper cell 11b Overflow prevention partition 11c Overflow prevention wall 12a Reference liquid flow passage 13a Sample liquid flow passage 16a, 16b Grip projection 11b 10c, 9f Notch

Claims (4)

[Claims] 1. A chemical sensor plate body in which at least one pair of a sample liquid measuring electrode having a coating film of a chemically sensitive film and a reference electrode is provided on a substrate, and a sample liquid is supplied to the sample liquid measuring electrode. A closed flow passage and a closed flow passage for supplying the reference liquid to the reference electrode are formed on the surface of the substrate, respectively, and an upper portion having a sample liquid introduction part and a reference liquid introduction part communicating with one end of each of the flow passages. A chemical sensor plate having at least a cell, wherein the sample liquid introduction part and the reference liquid introduction part are covered except for the introduction holes for introducing the sample liquid and the reference liquid, respectively. 2. A chemical sensor plate main body in which at least one pair of a sample liquid measuring electrode having a coating film of a chemically sensitive film and a reference electrode is provided on a substrate, and a sample liquid is supplied to the sample liquid measuring electrode. A closed flow passage and a closed flow passage for supplying the reference liquid to the reference electrode are formed on the surface of the substrate, respectively, and an upper portion having a sample liquid introduction part and a reference liquid introduction part communicating with one end of each of the flow passages. A cell and at least a partition wall between the sample liquid introduction part and the reference liquid introduction part is provided on the outer upper surface of the sample liquid introduction part and the reference liquid introduction part. A chemical sensor plate with a continuous liquid overflow prevention wall on the partition wall. 3. A chemical sensor plate body in which at least one pair of a sample liquid measurement electrode having a coating film of a chemically sensitive film and a reference electrode is provided on a substrate, and a sample liquid is supplied to the sample liquid measurement electrode. A closed flow passage and a closed flow passage for supplying the reference liquid to the reference electrode are formed on the surface of the substrate, respectively, and an upper portion having a sample liquid introduction part and a reference liquid introduction part communicating with one end of each of the flow passages. A chemical sensor plate having at least a cell and having a shape for preventing erroneous mounting on a measuring device. 4. A chemical sensor plate main body in which at least one pair of a sample liquid measuring electrode having a coating film of a chemically sensitive film and a reference electrode is provided on a substrate, and a sample liquid is supplied to the sample liquid measuring electrode. A closed flow passage and a closed flow passage for supplying the reference liquid to the reference electrode are formed on the surface of the substrate, respectively, and an upper portion having a sample liquid introduction part and a reference liquid introduction part communicating with one end of each of the flow passages. A chemical sensor plate having at least a cell, and having a gripping shape for measurement operation in at least one of the sample solution input section and the reference solution input section.