JP4041560B2 - Disposable component detector for test liquid analyzer and method for supplying test liquid to the component test tool - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
  The present invention relates to a component detector that can be used in a test liquid analyzer that can measure and analyze gas components, pH values, and the like in test liquids such as body fluids of humans and animals.And the component inspection toolThe present invention relates to a method for supplying a test solution to the above.
[0002]
[Prior art]
  This type of test liquid analyzer is used for the purpose of examining the cardiopulmonary function of a patient in a facility such as a hospital or analysis center or outdoors such as an accident site, for example, in order to check the blood acidity pH, carbon dioxide partial pressure PCO2, oxygen partial pressure. Such as PO2, sodium Na, potassium K, chlorine Cl, ionized calcium Ca, urea nitrogen BUN, glucose Glu, hematocrit Hct, bicarbonate ion HCO3-, oxygen saturation SO2, total carbon dioxide TCO2, base excess BE, hemoglobin Hgb It is used to measure and analyze various gas concentrations and ion concentrations, and various types of stationary and portable types have been proposed and put into practical use.
  In particular, as a portable analyzer, for example, in Japanese Patent Publication No. 8-20398, a component detector provided with a sensor device having a plurality of detectors for detecting components in a test solution is provided separately from the analyzer main body. A type of analyzer is disclosed.
  The component detector described above is
  In the housing
  A holding unit for holding a liquid sample to be analyzed (hereinafter referred to as a test solution according to the present application);
  A test liquid passage communicating with the holding portion;
  A sensor device provided in the middle of the test liquid passage;
  A reservoir provided downstream of the test liquid passage;
  An air accommodating portion that contains a predetermined amount of air inside and has a portion that can be deformed by a pressing force from the outside;
  An air pressure supply path communicating the air accommodating part and the holding part;
  The test liquid analyzer main body is detachable.
  When using the component detection tool configured as described above, first, the operator drops the test liquid to be analyzed on the holding unit of the component test tool, and causes the component test tool to hold the test liquid. After that, the component detector is attached to the analyzer, the air accommodating part is pressed by the pressing means provided on the analyzer side, the air in the air accommodating part is pushed out to the holding part, and this air pressure causes the holding part to The held test liquid is caused to flow through the test liquid passage and is brought into contact with the detection unit of the sensor device.
[0003]
[Problems to be solved by the invention]
  As described above, to mount the component detector on the analyzer while dropping the test liquid on the component detector before the component detector is mounted on the analyzer, and holding the test liquid. In order to prevent the test liquid held in the holding part from coming into contact with the atmosphere, the holding part must be provided with an airtight lid. Quick work of closing is required.
  In particular, portable test solution analyzers that use such component detectors are more likely to be used outdoors, such as at accident sites and in ambulances, and more than in facilities such as hospitals or analysis centers where they can work calmly. Since it is often used in relatively busy situations such as in a vehicle inside, it is often necessary for the operator to close the lid quickly so that the test solution does not touch the outside air as described above. It is cruel to it.
  Moreover, no matter how much the lid is closed immediately after dropping the test droplet, it is not possible to completely avoid exposure of the test solution to the atmosphere. A fatal problem also arises.
  Furthermore, as described above, in order to hold the test solution even temporarily, a space for holding the test solution such as a holding part must be provided in the component detection tool in addition to the test solution passage. In order to reduce the size of the tool, the capacity of the holding part must be reduced. However, if the capacity of the holding part is small, it is difficult for the operator to accurately drop the test liquid onto the holding part. Problems arise. In particular, in the case of a test solution that may cause an infection such as blood, the operator must avoid touching the test solution directly. It will be very cruel.
[0004]
  The present invention solves various problems caused by adopting a method of supplying a test solution to a component test tool before mounting the above-described component detection tool on the analyzer, and burdens on the operator's supply work of the test solution. Disposable component detector for test solution analyzerAnd the component inspection toolIt is an object to provide a method of supplying a test solution for the above.
[0005]
[Means for Solving the Problems]
  In order to achieve the above object, a disposable component detector for a test liquid analyzer according to the present invention comprises:Provided with a test liquid passage inside the housing, provided with a test liquid supply part capable of sealingly inserting a test liquid injector in an upstream part of the test liquid path, and provided with an exhaust hole in a downstream part of the test liquid path, A sensor device capable of detecting at least one component of the test liquid supplied in the test liquid passage between the test liquid supply section and the exhaust hole in the test liquid path, and the detection section in the test liquid path Provided in such a manner that it is exposed at a portion between the test liquid supply part and the exhaust hole and its terminal part is exposed to the outside of the housing. A calibration liquid passage that branches from the liquid supply section is provided, and a calibration liquid container that discharges the internal calibration liquid to the calibration liquid passage by an external pressing force is provided in an upstream portion of the calibration liquid passage. , Supply of the test solution And the width of the passage upstream of the portion where the calibration fluid passage branches in the passage is narrower than the passage width of the passage downstream thereof, and the terminal portion is at least one in the test solution based on the detection result of the detection portion. It is characterized in that it can be connected to an analyzer capable of analyzing two components.
Also according to the present inventionThe test liquid supply method for the disposable component detector for the test liquid analyzer isProvided with a test liquid passage inside the housing, provided with a test liquid supply part capable of sealingly inserting a test liquid injector in an upstream part of the test liquid path, and provided with an exhaust hole in a downstream part of the test liquid path, A sensor device capable of detecting at least one component of the test liquid supplied in the test liquid passage between the test liquid supply section and the exhaust hole in the test liquid path, and the detection section in the test liquid path Provided in such a manner that it is exposed at a portion between the test liquid supply part and the exhaust hole and its terminal part is exposed to the outside of the housing. A calibration liquid passage that branches from the liquid supply section is provided, and a calibration liquid container that discharges the internal calibration liquid to the calibration liquid passage by an external pressing force is provided in an upstream portion of the calibration liquid passage. , Supply of the test solution And the width of the passage upstream of the portion where the calibration fluid passage branches in the passage is narrower than the passage width of the passage downstream thereof, and the terminal portion is at least one in the test solution based on the detection result of the detection portion. In a disposable component detector for a test liquid analyzer configured to be connectable to an analyzer capable of analyzing two components, at least a part of the test liquid supply unit of the disposable component detector is exposed to the outside of the test liquid analyzer. After connecting the test liquid analyzer and pressing the calibration liquid container to release the calibration liquid into the test liquid passage and calibrating the detection part of the sensor device, the test liquid is supplied to the test liquid supply part. The contained test liquid injector is hermetically inserted, and the test liquid is injected with the test liquid injector.
[0006]
DETAILED DESCRIPTION OF THE INVENTION
  Embodiments of a disposable component inspection tool and a test liquid supply method for the component test tool (hereinafter simply referred to as a test liquid supply method) according to the present invention will be described below with reference to FIGS. I will explain it with reference.
[0007]
  FIG.Is for carrying out the test liquid supply method according to the present invention.Disposable component detector according to the present inventionFIG.2FIG. 4 is a schematic top view of a test liquid passage in a detection tool after housing assembly described later.
  As shown in the drawings, the detector comprises a housing 1 made of a suitable material such as a transparent or translucent plastic. The housing 1 is composed of two substrates 1A and 1B that are superposed on each other and a thin partition plate 1C that has an adhesive layer on both sides. The partition plate 1C is sandwiched between the two substrates 1A and 1B. Thus, the two substrates 1A and 1B are assembled so as to be liquid-tightly joined.
[0008]
  One substrate 1A has a test liquid passage 2 formed of a groove through which a test liquid such as a body fluid of a human or an animal to be tested is formed on an inner side surface thereof, that is, a surface facing the thin partition plate 1C, at a peripheral edge of the substrate 1A. It is formed in a U shape along. A test liquid injection hole 3 communicating with the outside of the housing is formed at the upstream end of the test liquid passage 2, and a first waste liquid portion formed in a zigzag shape in the downstream portion of the test liquid passage 2. 4 is formed.
  Figure3FIG. 4 is a partial cross-sectional view of a portion corresponding to the injection hole 3 in the base 1A. As shown in the drawing, the injection hole 3 is slightly tapered from the inner side surface to the outer side surface of the substrate 1A. A guide shoulder 3a is provided around the injection hole 3 on the side surface. Thus, a test liquid injector (not shown) such as a syringe can be hermetically inserted into the injection hole 3, and the test liquid can be injected into the test liquid passage 2 without touching the atmosphere.
[0009]
  The grooves constituting the first waste liquid part 4 are1 and 2Are formed in a zigzag shape, and the width and depth thereof are set larger than other portions of the test liquid passage 2 in order to obtain a sufficient volume.
  In addition, the test liquid passage 2 is1 and 2As shown in FIG. 2, a relatively narrow portion 2a extending from the injection hole 3, a detection portion contact portion 2b following the relatively narrow portion 2a, a constricted portion 2c connected to the detection portion contact portion 2b, And a portion 2 d extending from the constricted portion 2 c to the first waste liquid portion 4. A narrow groove 6 constituting a part of the calibration liquid passage is formed inward in the upstream portion of the sensor contact portion 2b of the inspection liquid passage 2. Further, a branch passage 7 extending toward the peripheral edge is formed in the sensor contact portion 3 b of the test liquid passage 3, and the tip end of the branch passage 7 terminates in the through hole 8. The through hole 8 is positioned so as to face the reference electrode, and can be filled with a gel-like saturated potassium chloride solution.
  Further, an opening 9 is formed in an inner region surrounded by the U-shaped test solution passage 2 of one substrate 1A, and this opening 9 is a means for pressing a calibration solution container described later at the time of measurement. Is provided to receive.
  Furthermore, a through-hole 10 for guiding and locking when a detection tool is inserted into a test liquid analyzer to be described later is provided in the substantially central portion of one substrate 1A.
[0010]
  On the other substrate 1B, a shallow concave surface 12 for mounting the sensor device 11 is formed along one corner on the inner surface, that is, the surface facing the thin partition plate 1C. A mounting concave surface 14 for the calibration liquid container 13 is formed at a position corresponding to the opening 9.
  FIG.FIG. 4 is an enlarged view of a portion corresponding to the mounting concave surface 14 in the calibration liquid container 13 and the substrate 1B. As shown in the drawing, the calibration liquid container 13 is made of a material having no or low gas permeability and has a sensor inside. A reagent for calibration of each detection unit in the apparatus 11 is hermetically contained. In this embodiment, the calibration liquid container is bonded to the outer peripheral edge portion 13a at such a strength that it is not peeled off by an internal pressure when it is pressed at least by the pressing means of the analyzer described later. The outer peripheral edge portion 13a is formed with a discharge portion 13b, and a portion corresponding to the discharge portion 13b is made of an easily peelable sealant that can be peeled at least by an internal pressure when pressed by a pressing means of an analyzer described later. It is glued. As the peeling mechanism using this easy-to-peel sealant, the sealant and the adherend are not completely fused and can be peeled off at an appropriate strength. A mechanism or a cohesive peeling mechanism that peels by internal cohesive failure of the sealant layer when opened can be considered.
  By forming the calibration liquid container as described above, only the discharge portion 13b is peeled off when being pressed by the pressing means of the analyzer described later, so that the reagent inside can be released from the calibration liquid container. . In this way, the strength of the calibration liquid container is improved as compared with a detector that uses a configuration that tears the calibration liquid container with needles to release the calibration liquid by forming the release part using an easy-release sealant. As a result, since a material having low gas permeability can be used, the storage stability of the reagent when storing the detector is remarkably improved.
  Further, the position corresponding to the free end of the narrow groove 6 constituting a part of the calibration liquid passage in one substrate 1A from the portion corresponding to the discharge portion 13b of the calibration liquid container 13 of the mounting concave surface 14 in the substrate 1B. Up to this point, a narrow groove 16 forming a part of the calibration liquid passage is formed. The fine groove 16 communicates with the fine groove 6 formed in one of the substrates 1A through a hole 23 provided in the partition plate 1C when assembled so as to constitute a single calibration liquid passage to form the calibration liquid. In order to make the discharge part 13b of the container 13 communicate with the test liquid passage 2 and to calibrate each sensor of the sensor device 11 prior to measurement of the test liquid, the calibration liquid container 13 is pressed by the pressing means of the analyzer, and the discharge When the part 13 b is peeled off, the calibration liquid in the calibration liquid container 13 is caused to flow to the detection part contact part 2 b in the test liquid passage 2.
  Although not shown in detail in the drawing, the reagent is supplied from the discharge portion 13b of the calibration liquid container 13 to the calibration liquid container mounting concave surface 14, the narrow groove 16 forming a part of the calibration liquid passage, and the calibration liquid container 13. It goes without saying that various structures such as providing a guide groove to ensure that the reagent flows into the narrow groove 16 without leaking to other parts when released are taken.
[0011]
  Reference numeral 17 denotes a second waste liquid portion composed of zigzag grooves formed symmetrically with the waste liquid portion 4 at a position corresponding to the first waste liquid portion 4 on one substrate 1A. The part 17 constitutes a single waste liquid passage that communicates with the first waste liquid part 4 formed on one substrate 1A through a hole 24 provided in the partition plate 1C when assembled (see FIG.2reference). Further, an exhaust hole 18 communicating with the outside is formed at the downstream end of the waste liquid part 17.FIG.As shown in FIG. 2, a plug member 19 that is permeable to air and impermeable to liquid is mounted (see FIG.5These show the fragmentary sectional view of the exhaust hole 18 portion in the substrate 1B. ).
  The plug member 19 is made of, for example, a porous synthetic resin made of a water-repellent material containing a water-absorbing resin having a high water absorption rate, and a test liquid such as blood is injected from the injection hole 3 with a test liquid injector. When the test solution reaches the plug member 19, the water absorbent resin absorbs the test solution and expands to close the holes of the porous synthetic resin, so that the plug member 19 seals the exhaust hole 18. However, the test solution can no longer be injected with the injector. Thereby, since the inside of the inspection liquid passage 2 is reliably filled with the inspection liquid from the injection hole 3 to the exhaust hole 18, the inspection liquid is provided in the detection portion of the sensor device 11 provided between the injection hole 3 and the exhaust hole 18. Is reliably supplied.
[0012]
  Figure6FIG. 2 is a schematic enlarged view of the sensor device 11. As shown in the drawing, the sensor device 11 includes a plurality of detection portions 11b having electrodes formed by applying conductive ink on an insulating substrate 11a.
  The detection unit 11b includes acidity PH, carbon dioxide partial pressure PCO2, oxygen partial pressure PO2, sodium Na, potassium K, chlorine Cl, ionized calcium Ca, urea nitrogen BUN, glucose Glu, hematocrit Hct, bicarbonate ion HCO3-, Depending on the component to be detected such as oxygen saturation SO2, total carbon dioxide TCO2, excess base BE, hemoglobin Hgb, etc., the gas component to be detected can permeate the portion corresponding to the test liquid passage 2 of each electrode. A gas permeable membrane or a reagent layer formed by applying a chemical substance or a natural substance that reacts with a component to be detected can be appropriately provided.
  The detection unit 11b further includes a counter electrode when, for example, a current detection method is used to measure the oxygen partial pressure and glucose concentration in the blood, and also includes hydrogen, sodium, potassium, etc. in the test solution. When using a potential difference detection method to measure the ion concentration, a reference electrode is further provided. Further, when measuring the conductivity in the test solution to measure the amount of hematocrit, an alternating voltage is applied between them. Various forms can be taken according to the component which should be detected, such as applying.
  In the illustrated embodiment, the detection unit 11b is arranged so as to be able to measure eight kinds of inspection values among these inspection values.
  Each detection unit 11b is connected to a terminal 11e arranged along one side edge of the substrate 11a through a conductor 11d formed by applying conductive ink. These terminals 11e assemble the housing 1. Is disposed so as to be exposed to the outside from the substrate 1A. That is,FIG.FIG. 2 is a schematic perspective view showing a state in which the housing 1 is assembled. As can be seen from this drawing, the width of one substrate 1A is slightly smaller than the other substrate 1B, and the terminal 11e has two substrates 1A and 1A. It is arranged at a portion protruding from the substrate 1A in the substrate 1B when 1B is stacked.
  As the insulating substrate, any insulating material can be used as long as it is made of a material that is not affected by the test solution, such as ceramic, glass, glass epoxy, and plastic. However, since it is disposable, it is inexpensive and easy to handle. Plastic films such as vinyl, polyester, polyethylene, and polypropylene are preferred.
  In addition, as a printing method for applying the conductive ink, a screen printing method capable of forming a uniform material in a large quantity efficiently can be considered, but the ink jet method, nozzle coating method, dispenser is not limited thereto. Any method such as printing or casting can be used.
[0013]
  A through hole 20 is provided at a position on the other substrate 1B corresponding to the through hole 10 in one substrate 1A, and when the two substrates 1A and 1B are bonded together, the through holes 10 and 20 are aligned. It is made to agree.
[0014]
  Further, the partition plate 1C is provided with a plurality of openings 21 at positions along the detection passage 2b and the branch passage 7 of the test liquid passage 2 on one substrate 1A. The inspection liquid flowing into the contact portion 2b and the branch passage 7 is brought into contact with the detection portions 11c and the electrodes 11b on the other substrate 1B through these openings 21.
  Further, the partition plate 1C includes a hole 22 provided at a position corresponding to the through hole 10 on one substrate 1A and the through hole 20 on the other substrate 1B, the free end of the narrow groove 6 on one substrate 1A, and the other substrate. A hole 23 for communicating with the free end of the narrow groove 16 of 1B to form one calibration liquid passage, and the waste liquid part 4 of one substrate 1A and the waste liquid part 17 of the other substrate 1B are continuously communicated. A hole 24 for forming the waste liquid portion is provided.
[0015]
  Figure8FIG. 1 shows a schematic perspective view of a portable analyzer as an embodiment of a test liquid analyzer that can use the detection tool according to the present invention.9FIG. 3 is a block diagram schematically showing internal processing of the analyzer.
  This portable analyzer is a figure1~ Figure7The insertion port 30 into which the card-type disposable detector illustrated in Fig. 5 is inserted, the arithmetic processing unit 31 that performs arithmetic processing on the output signal detected by each detection unit in the card-type disposable detector, and the calculation result of the arithmetic processing unit 31 are stored. The storage unit 32 includes a display unit 33 that is arranged on the upper surface of the casing and displays calculation result data of the calculation processing unit 31, and a printer 34 that prints calculation result data of the calculation processing unit 31. Figure8The display unit 33 includes an operation unit of the apparatus, and a calibration liquid container pressing means is provided inside the apparatus, and the calibration liquid container pressing means is inserted by inserting a card-type disposable detector. , Is made operable.
[0016]
  The process from the detection liquid injection to the component analysis using the analyzer configured as described above and the detection tool will be described by taking a patient blood analysis as an example.
  First, the prepared card-type disposable detector is inserted into the insertion port 30 of the portable analyzer, and the calibration measurement of the detection unit of the sensor device is performed. That is, by inserting a card-type disposable detector, the measurement item is discriminated, the reagent container pressing means in the portable analyzer is automatically activated, and passes through the opening 9 formed on the substrate 1A of the detector. The calibration liquid container 13 is pressed with a predetermined pressure. As a result, the discharge part 13b of the calibration liquid container 13 is peeled off and the calibration liquid stored inside is released into the calibration liquid paths 6 and 16, and the detection part of the test liquid path 2 is passed through the calibration liquid paths 6 and 16. The proofreading liquid comes into contact with the contact portion 2b and contacts the detection portion 11b. The analyzer side calibrates each detector 11b based on the current value and voltage value detected from each terminal 11e at this time.
[0017]
  Thereafter, the nozzle of the syringe containing the blood collected from the patient is fitted into the injection hole 3 in the card-type disposable detector, and the blood is injected into the internal test liquid passage 2. At this time, since the test liquid passage 2 has a relatively narrow portion 2a upstream of the detection portion contact portion 2b and a constricted portion 2c on the downstream side, the blood injection pressure varies. However, the injected blood flows slowly and stably along the detection portion contact portion 2b of the test fluid passage 2, and each detection portion of the sensor device can detect a desired test value stably and accurately. it can. Thus, the blood that has passed through the detection portion abutting portion 2b of the test fluid passage 2 flows from the constricted portion 2c through the downstream portion 2d to the first waste liquid portion 4. In this case, during the blood injection by the syringe, the blood injection amount can be easily recognized by monitoring the blood accumulation state in the first waste liquid part 4 from the outside. Further, the exhaust hole 18 formed in the downstream end of the second waste liquid part 17 connected to the first waste liquid part 4, that is, the downstream end part of the test liquid passage 2, is permeable to air and liquid. On the other hand, since the impervious plug member 19 is attached, blood is injected to the plug member 19 and the test liquid passage 2 becomes full even if the amount of special blood injected is not carefully monitored. The plug member 19 seals the exhaust port 18 so that blood can no longer be automatically injected.
  Unlike the conventional method in which the blood that has been injected is held in the test tool and the test value of the blood held in the test tool is measured after the calibration operation, in the present invention, the blood injection into the test tool is performed. Since the blood test values are measured substantially simultaneously, accurate measurement values can be obtained.
[0018]
  In this way, the current value and voltage value detected by each detection unit 11b are sent from the terminal 11e to the calculation processing unit 31 in the portable analyzer, where the calculation is performed, and the acidity PH, carbon dioxide partial pressure PCO2, oxygen content is calculated. Pressure PO2, sodium Na, potassium K, chlorine Cl, ionized calcium Ca, urea nitrogen BUN, glucose Glu, hematocrit Hct, bicarbonate ion HCO3-, oxygen saturation SO2, total carbon dioxide TCO2, excess base BE, hemoglobin Hgb Various data on various gas concentrations and ion concentrations are output. On the one hand, these data are stored in the storage unit 33 and displayed on the display unit 33 disposed on the upper surface of the casing. These data can be printed out by operating the printer 34 if necessary.
[0019]
As described above, by injecting the test liquid into the component detection tool after the component detection tool is mounted on the analysis apparatus, the injected test liquid can be immediately brought into contact with the sensor device and component analysis can be performed by the analysis apparatus. As a result, the test solution is not exposed to the atmosphere at all and the component analysis can be performed with high accuracy.
In addition, the operator does not need to perform the complicated work of dripping the test solution carefully onto the holding part and closing the lid immediately after dropping, as in the case of the conventional component detector, so as not to leak the test solution. The operation is very simple because the nozzle portion of the injector is simply fitted into the injection hole and an appropriate amount of the test solution is injected.
In addition, a plug member made of a material that is permeable to air and impermeable to liquid may be provided in the exhaust hole so that the test solution is injected until the test solution reaches the plug member. Since the operator does not have to pay attention to the injection amount, the operation is further simplified.
  The component detector shown in the illustrated embodiment is an example of a component detector for carrying out the detection liquid injection method of the present invention, and its configuration is not limited to this embodiment, and is attached to the analyzer. In this case, the housing 1 is composed of two substrates 1A and 1B and a partition plate 1C. However, this is not limited to the present embodiment, and any configuration can be conceived as long as the test liquid passage can be formed therein. In the illustrated embodiment, the two substrates are entirely transparent or Although it is made of a translucent material, this is not limited to this embodiment, and may be made of an opaque material, and any state in the first and second waste liquid parts 4 and 17. Even if a part is made of a transparent material so that you can check There. Further, in this embodiment, the terminals of the sensor device are exposed by forming one substrate to be narrower than the other substrate, but the two substrates are configured to have the same dimensions and the terminals of the sensor device are arranged on the side surfaces thereof. You may comprise so that it may be exposed to. Furthermore, in the illustrated embodiment, the two substrates are bonded with a partition plate having an adhesive layer on both sides, but this is not limited to this embodiment, and even if directly bonded with an adhesive Good. Further, although the sensor device is provided separately from the housing, a detection unit or the like may be provided directly on the housing. Furthermore, the number of detection units can be arbitrarily set according to the number and type of inspection values.The
[0020]
【The invention's effect】
  The test liquid supply method for the disposable component detector for a test liquid analyzer according to the present invention is:Provided with a test liquid passage inside the housing, provided with a test liquid supply part capable of sealingly inserting a test liquid injector in an upstream part of the test liquid path, and provided with an exhaust hole in a downstream part of the test liquid path, A sensor device capable of detecting at least one component of the test liquid supplied in the test liquid passage between the test liquid supply section and the exhaust hole in the test liquid path, and the detection section in the test liquid path Provided in such a manner that it is exposed at a portion between the test liquid supply part and the exhaust hole and its terminal part is exposed to the outside of the housing. A calibration liquid passage that branches from the liquid supply section is provided, and a calibration liquid container that discharges the internal calibration liquid to the calibration liquid passage by an external pressing force is provided in an upstream portion of the calibration liquid passage. , Supply of the test solution And the width of the passage upstream of the portion where the calibration fluid passage branches in the passage is narrower than the passage width of the passage downstream thereof, and the terminal portion is at least one in the test solution based on the detection result of the detection portion. In a disposable component detector for a test liquid analyzer configured to be connectable to an analyzer capable of analyzing two components, at least a part of the test liquid supply unit of the disposable component detector is exposed to the outside of the test liquid analyzer. After connecting the test liquid analyzer and pressing the calibration liquid container to release the calibration liquid into the test liquid passage and calibrating the detection part of the sensor device, the test liquid is supplied to the test liquid supply part. Insert the contained test solution injector in a sealed manner, and inject the test solution with the test solution injector.Therefore, when injecting, the operator need not carefully perform the complicated work of dripping the test solution carefully onto the holding part and closing the lid immediately after dripping so as not to leak the test solution like the conventional component detector. In this case, it is only necessary to fit the nozzle portion of the injector into the injection hole and inject an appropriate amount of the test solution, thereby greatly reducing the burden on the injection operation.
  After the component detector is mounted on the analyzer, the test solution is injected into the component detector so that the injected test solution can be immediately contacted with the sensor device and analyzed by the analyzer. The test solution is not exposed to the atmosphere at all, and the component analysis with high accuracy can be performed.
  As described above, according to the test liquid supply method for the disposable component detector for a test liquid analyzer according to the present invention, even a component detector configured separately from the analyzer so as to be disposable can be used. Since the test solution can be injected in the same manner as the method of injecting the test solution into the stationary analyzer, the test solution injection process becomes very simple and the burden on the operator is reduced. Play.
[Brief description of the drawings]
[Figure 1]It is a general | schematic expanded view of one Example of the component detection tool which concerns on this invention for enforcing the detection liquid injection | pouring method concerning this invention.
[Figure 2]It is a schematic top view of the test liquid passage in the detection tool after housing assembly.
[Fig. 3]It is a fragmentary sectional view of a portion corresponding to the injection hole 3 in the base 1A.
[Fig. 4]It is an enlarged view of the part corresponding to the said mounting concave surface 14 in the calibration liquid container 13 and the board | substrate 1B.
[Figure 5]It is a fragmentary sectional view of exhaust hole 18 part in substrate 1B.
[Fig. 6]2 is a schematic enlarged view of a sensor device 11. FIG.
[Fig. 7]It is a schematic perspective view which shows the state which assembled the housing 1. FIG.
[Fig. 8]It is a schematic perspective view which shows one Example of the portable analyzer which can use the detection tool by this invention.
FIG. 9It is a block diagram which shows the structure of the portable analyzer shown in FIG.
[Explanation of symbols]
100 housing
101 Test solution passage
102 injection hole
103 Sensor device
104 exhaust hole
1 Housing
1A board
1B substrate
1C divider
2 Test liquid passage
2a A relatively narrow part extending from the injection hole 3
2b Detection part contact part
2c Constricted part
2d Part extending from the constricted part 2c to the first waste liquid part 4
3 injection hole
4 Waste liquid part
6 Narrow grooves that form part of the calibration fluid passage
7 branch passage
8 Through hole
9 Opening for pressing
10 Through hole
11 Sensor device
11a substrate
11b detector
11d conductor
11e terminal
12 Concave
13 Calibration solution container
13a outer peripheral edge
13b discharge part
14 Concave surface with calibration liquid container
16 Narrow groove that forms part of the calibration fluid passage
17 Second waste liquid section
18 Exhaust hole
19 Plug member
20 Through hole
21 opening
22 Through hole
23 Hole communicating with narrow grooves 6 and 16
24 Hole for communicating the first waste liquid part 4 and the second waste liquid part 17
30 insertion slot
31 Arithmetic processing part
32 storage unit
33 Display
34 Printer

Claims (4)

A test liquid passage is provided inside the housing,
  Provided with a test liquid supply section capable of sealingly inserting a test liquid injector in an upstream portion of the test liquid passage,
  An exhaust hole is provided in the downstream portion of the test liquid passage,
  A sensor device capable of detecting at least one component of the test liquid supplied in the test liquid passage between the test liquid supply section and the exhaust hole in the test liquid path, and the detection section in the test liquid path It is exposed at the part between the test solution supply part and the exhaust hole, and the terminal part is provided so as to be exposed outside the housing,
  A calibration liquid passage that branches from a portion of the test liquid passage where the detection unit of the sensor device is exposed and the test liquid supply section is provided, and a pressing force from the outside is provided in an upstream portion of the calibration liquid passage. Provides a calibration fluid container that discharges the calibration fluid inside to the calibration fluid passage, and
  The passage width on the upstream side of the portion where the calibration liquid passage in the inspection liquid supply passage branches is narrower than the passage width of the passage on the downstream side thereof,
  The terminal unit is configured to be connectable to an analyzer capable of analyzing at least one component in the test solution based on the detection result of the detection unit.
  A disposable component detector for a test fluid analyzer characterized by that. A plug member made of a material that is permeable to air and impermeable to liquid is provided in the exhaust hole.
  The disposable component inspection tool according to claim 1. A test liquid passage is provided inside the housing,
  Provided with a test liquid supply section capable of sealingly inserting a test liquid injector in an upstream portion of the test liquid passage,
  An exhaust hole is provided in the downstream portion of the test liquid passage,
  A sensor device capable of detecting at least one component of the test liquid supplied in the test liquid passage between the test liquid supply section and the exhaust hole in the test liquid path, and the detection section in the test liquid path It is exposed at the part between the test solution supply part and the exhaust hole, and the terminal part is provided so as to be exposed to the outside of the housing,
  A calibration liquid passage that branches from a portion of the test liquid passage where the detection unit of the sensor device is exposed and the test liquid supply section is provided, and a pressing force from the outside is provided in an upstream portion of the calibration liquid passage. Provides a calibration fluid container that discharges the calibration fluid inside to the calibration fluid passage, and
  The passage width on the upstream side of the portion where the calibration liquid passage in the inspection liquid supply passage branches is narrower than the passage width of the passage on the downstream side thereof,
  In the disposable component detector for a test solution analyzer configured to be connectable to an analyzer capable of analyzing at least one component in the test solution based on the detection result of the detection unit,
  The disposable component detector is connected to the test liquid analyzer such that at least a part of the test liquid supply unit is exposed to the outside of the test liquid analyzer,
  After calibrating the detection part of the sensor device by pressing the calibration liquid container and releasing the calibration liquid into the test liquid passage,
  A test liquid injector containing a test liquid is hermetically inserted into the test liquid supply section, and the test liquid is injected with the test liquid injector.
  A test liquid supply method for a disposable component detector for a test liquid analyzer. A plug member made of a material that is permeable to air and impermeable to liquid is provided in the exhaust hole,
  Inject the test solution until the test solution reaches the plug member
  The test liquid supply method according to claim 3.

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