JP3046992U - Disposable component detector for test solution analyzer - Google Patents

Abstract

(57) [Summary] (Modifications required) [Problem] It is possible to exhibit excellent performance from the viewpoint of storage and use, and to supply a high-quality calibration solution to the detection unit of the sensor device without fail. Provided is a disposable component detector for a test solution analyzer. A disposable component detector for a test liquid analyzer includes a test liquid passage 101 capable of supplying a test liquid to be analyzed inside a housing 100, and at least one of the test liquids supplied to the test liquid passage 101. Sensor device capable of detecting components
A calibration unit 103 is provided such that the detection unit is exposed in the test liquid passage 101 and the terminal unit is exposed outside the housing 100, and the detection unit of the sensor device 103 contains a reagent capable of calibrating the detection unit. A liquid container 105 is provided, and an easy-peeling release part that can be peeled at a predetermined pressure on at least a part of the calibration liquid container 105.
105a is provided.

Description

[Detailed description of the invention]

[0001]

[Technical field to which the invention belongs]

 The present invention provides an improved device for detecting components in a test solution that can be used in a test solution analyzer that can measure and analyze gas components, pH values, etc. in test solutions such as body fluids of humans and animals. About.

[0002]

[Prior art]

 This type of test solution analyzer is used for examining the cardiopulmonary function of a patient, for example, inside a facility such as a hospital or an analysis center, or outdoors such as at an accident site, etc. Pressure PO2, sodium Na, potassium K, chlorine Cl, calcium ion Ca, urea nitrogen BUN, glucose Glu, hematocrit Hct, bicarbonate ion HCO3-, oxygen saturation SO2, total carbon dioxide TCO2, excess base BE, It is used for measuring and analyzing the concentration of various gases and ions such as hemoglobin Hgb, and various stationary and portable types have been proposed and put to practical use. Specifically, for example, Japanese Patent Publication No. Hei 8-20398 discloses a component detector provided with a sensor device having a plurality of detectors for detecting components in a test solution, which is provided separately from the main body of the analyzer. An analysis device is disclosed. The above-described component detector includes: a holding portion for holding a liquid sample to be analyzed in the housing (hereinafter, referred to as a test solution), a test solution passage communicating with the holding portion, and a test solution passage. A storage device provided downstream of the test liquid passage, and an air storage portion that contains a predetermined amount of air therein and has a portion that can be deformed by an external pressing force. An air pressure supply path communicating the air storage unit and the holding unit; and a calibration liquid container capable of supplying a calibration liquid to a detection unit of the sensor device in the test liquid passage, which is detachably attached to the test liquid analyzer main body. Is configured. As described above, the component detector has a needle-like member provided at a portion corresponding to the calibration liquid container in the housing of the component detector, and a calibration liquid pressing means for pressing the calibration liquid container is provided on the test liquid analyzer side. After the test solution to be analyzed is dropped into the test part, when the component detector is attached to the test solution analyzer, the calibration solution pressing means on the test solution analyzer side presses the calibration solution container, whereby the calibration solution container is pressed. Is perforated by the needle-shaped member, and the calibration liquid contained therein is discharged into the test liquid passage, so that the calibration operation of each detection unit can be first performed on the analyzer side. The test liquid held in the section is supplied into the test liquid passage. This allows the conventional component detector to automatically calibrate each detection unit with the calibration solution before performing the component analysis of the test solution, simplifying the calibration process and subsequently analyzing the component of the test solution. Also can be performed accurately.

[0003]

[Problems to be solved by the invention]

 By the way, in the above-mentioned calibration liquid, the gas component vaporized during storage is leaked to the outside through the container, or when the gas exchange with the outside air is performed, the accuracy of the calibration is reduced. It is desirable that the gasket should be sealed and stored in a container with low gas permeability so that it does not leak gas as much as possible and is not exposed to the outside atmosphere. Aluminum pack can be considered as a material with low gas permeability, however, no matter what material is used, from the viewpoint of storage of this calibration solution, it is desirable that the outer shell of the calibration solution container be thick and high in strength. . However, when a configuration is used in which the calibration liquid container is pierced with a needle-like member by the pressing force of the analyzer during use and the internal calibration liquid is released, as in the above-described conventional component detection tool, naturally, It is desirable that the outer shell of the calibration solution container is not too thick and that the strength is not too high so that holes can be easily formed. As described above, the conventional component detector requires the material and thickness of the calibration liquid container to be contradictory between the storage surface and the use surface. In addition, there is a problem in that the pressing force of the pressing means of the analyzer must be adjusted, which makes the production extremely troublesome. This is because, for example, if the outer shell of the calibration solution container is too thin and the gas permeability increases, gas components vaporized from the calibration solution during storage will leak through the outer skin of the container during storage. And the accuracy of the analysis results is deteriorated, and the calibration process itself cannot be performed if the outer shell of the calibration solution container is too thick and the perforation by the needle-shaped member during use fails. However, both are very serious problems because they can be fatal drawbacks as a component detector used in an analyzer.

Accordingly, the present invention solves the problems associated with such a conventional disposable component detector for a test solution analyzer, and can exert excellent capabilities in terms of storage and use. It is an object of the present invention to provide a disposable component detector for a test solution analyzer capable of reliably supplying a high-quality calibration solution to a detection unit of a sensor device.

[0005]

[Means for Solving the Problems]

 In order to achieve the above object, the disposable component detector for a test solution analyzer according to the present invention has a test solution passage capable of supplying a test solution to be analyzed inside a housing, and supplies the test solution passage to the test solution passage. A sensor device capable of detecting at least one component of the test liquid thus obtained, such that a detection portion thereof is exposed in the test liquid passage and a terminal portion thereof is exposed to the outside of the housing. A calibration solution container containing a reagent capable of calibrating the detection unit of the apparatus is provided, and an easy-peeling release unit capable of peeling at a predetermined pressure is provided on at least a part of the calibration solution container. The test liquid passage is arranged at a position where the reagent can be discharged upstream of the detection unit of the sensor device in the test liquid passage, and the terminal unit is connected to at least one component in the test liquid based on the detection result of the detection unit. It is characterized in that it has configured to allow detachably connected to analyze possible analyzer.

[0006]

[Embodiment of the invention]

 FIG. 1 is a schematic top view of a disposable component detector (hereinafter simply referred to as a detector) for a test liquid analyzer according to one embodiment of the present invention. As shown in FIG. 1, the detection tool includes a test liquid passage 101 inside a housing 100, and a test liquid supply unit 102 is provided at an upstream end of the test liquid passage 101. A sensor device 103 for detecting a component to be analyzed in the test liquid is provided downstream of the test liquid supply unit 102. Although not shown in detail, the sensor device 103 is arranged such that its detecting portion is exposed in the test solution passage 101 and its terminal portion is exposed outside the housing 100. The configuration is such that a terminal portion can be attached to an analyzer (not shown). A calibration liquid supply passage 104 is provided at a portion between the test liquid supply unit 102 and the sensor device 103 in the test liquid passage 101, and a calibration liquid container is provided at an upstream end of the calibration liquid supply passage 104. 105 is provided. The calibration liquid container 105 is formed of a material such as aluminum having low gas permeability, and contains therein a calibration liquid for performing a calibration process on the sensor of the sensor device 103. In this case, the container may have a thickness and strength capable of preventing gas components vaporized from the calibration liquid contained therein from passing through and preventing the gas from leaking to the outside. The calibration liquid container 105 includes a discharge portion 105a that can be opened, and the discharge portion 105a is joined so as to be easily peelable at a predetermined pressure. As an easily peelable bonding method, for example, adhesion using an easily peelable sealant can be considered. Specifically, an interface in a state where the sealant and the adherend are not completely fused and can be peeled with an appropriate strength. A peeling mechanism, an interlayer peeling mechanism capable of peeling between the coating layer and the laminate film, or a cohesive peeling mechanism that peels due to internal cohesive failure of the sealant layer at the time of opening can be considered. Further, the easily peelable release portion 105a is disposed so as to face the calibration liquid supply passage 104, so that when the calibration liquid container 105 is pressed at a predetermined pressure, the easily peelable release portion 105a is peeled. Then, the internal calibration liquid is supplied to the sensor device 103 arranged in the test liquid passage 101. The above-described pressing of the calibration liquid container 105 is preferably performed automatically by the analyzer after the component detector is mounted on the analyzer, but the calibration liquid container is exposed from the analyzer when mounted on the analyzer. The component detector may be configured as described above, and the operator may press the calibration liquid container with a finger or the like. Further, the discharge part in the calibration liquid container is preferably formed partially so as to face the calibration liquid supply passage as described above, but, for example, such that the entire calibration liquid container is decomposed by a predetermined pressure, for example, Alternatively, the outer peripheral portions of the two packaging sheets may all be joined so as to be easily peelable. Various forms of the test liquid supply unit 102 in the test liquid passage 101 can be considered. For example, the test liquid supply unit 102 can be formed in the form of a test liquid injection hole, and the test liquid can be directly supplied to the test liquid passage 101 with a syringe or the like. In addition, a holding unit for temporarily holding the test liquid as in a conventional component detection tool, and an air storage unit for supplying air to the holding unit are provided and held on the holding unit. The test liquid may be supplied to the sensor device 103 by air pressure from the air storage unit. When the test liquid supply unit 102 is configured as in the former, an exhaust hole is provided downstream of the test liquid passage 101, and the exhaust hole is permeable to air and impermeable to liquid. If a plug member made of a material, for example, a water-repellent porous synthetic resin body containing a water-absorbing synthetic resin is provided, the test liquid cannot be injected any more when the test liquid passage is full. This eliminates the need for this, and can reduce the burden on the operator who injects the test solution. Further, a waste liquid portion having a volume capable of storing a predetermined amount of the test liquid may be provided downstream of the sensor device 103, and an exhaust hole may be provided downstream of the waste liquid portion. By providing the waste liquid portion in this way, it becomes possible to cope with variations in the injection amount of the test liquid and the supply amount of the calibration liquid. Furthermore, when the test liquid supply unit is in the form of an injection hole, the injection hole can be configured so that the nozzle portion of the test liquid injector can be fitted in a liquid-tight manner. According to the shape and shape, the nozzle portion may be tapered so that it can be fitted in a liquid-tight manner, and a seal member may be provided at the injection hole and / or the nozzle portion of the injector.

[0007]

【Example】

 Next, a more specific embodiment of the detector according to the present invention will be described with reference to one embodiment shown in FIGS. FIG. 2 is a schematic development view of the detection tool according to the present invention, and FIG. 3 is a schematic top view of a test liquid passage in the detection tool after the housing is assembled, which will be described later. As shown in the figures, the detector comprises a housing 1 made of a suitable material such as a transparent or translucent plastic. The housing 1 is composed of two substrates 1A and 1B which are superimposed on each other and a thin partition plate 1C having an adhesive layer on both sides. The partition plate 1C is sandwiched between the two substrates 1A and 1B. Is assembled so that the two substrates 1A and 1B are joined in a liquid-tight manner.

On one substrate 1A, on the inner surface, that is, the surface facing the thin partition plate 1C, a test solution passage 2 formed by a groove for passing a test solution such as a body fluid of a human or animal to be tested is formed. It is formed in a U-shape along the peripheral edge. At the upstream end of the test liquid passage 2, an injection hole 3 for the test liquid communicating with the outside of the housing is formed, and at the downstream portion of the test liquid passage 2, a first waste liquid formed in a zigzag shape is formed. The part 4 is formed. FIG. 4 is a partial cross-sectional view of a portion corresponding to the injection hole 3 in the base 1A. As shown in the drawing, the injection hole 3 is slightly tapered from the inner surface to the outer surface of the substrate 1A. A guide shoulder 3a is provided around the injection hole 3 on the outer surface of the body. As a result, a test liquid injector (not shown) such as a syringe can be hermetically inserted into the injection hole 3, and the test liquid can be injected into the test liquid passage 2 without touching the atmosphere.

The grooves constituting the first waste liquid portion 4 are formed in a zigzag as shown in FIGS. 2 and 3, and the width and depth thereof are different from those of the test liquid passage 2 to obtain a sufficient volume. It is set larger than the part. As shown in FIGS. 2 and 3, the test solution passage 2 has a relatively narrow portion 2a extending from the injection hole 3, a detecting portion contact portion 2b following the relatively narrow portion 2a, and a detecting portion. It has a constricted portion 2c following the part contact portion 2b, and a portion 2d extending from the constricted portion 2c to the first waste liquid portion 4. On the upstream side of the sensor contact portion 2b of the test liquid passage 2, a narrow groove 6 forming a part of the calibration liquid passage is formed inward. Further, a branch passage 7 extending toward the peripheral edge portion is formed in the sensor contact portion 3b of the test liquid passage 3, and the leading end of the branch passage 7 terminates in a through hole 8. The through hole 8 is positioned so as to be opposed to the reference electrode, and can be loaded with a gel-like saturated potassium chloride solution. Further, an opening 9 is formed in an inner region of the one substrate 1A surrounded by the U-shaped test liquid passage 2, and this opening 9 is a means for pressing a calibration liquid container described later at the time of measurement. It is provided to receive. Furthermore, a through hole 10 for guiding and locking when a detection tool is inserted into a test liquid analyzer described later is provided at a substantially central portion of one substrate 1A.

On the other side of the substrate 1B, a shallow concave surface 12 for mounting the sensor device 11 is formed along one corner on the inner surface thereof, that is, the surface facing the thin partition plate 1C. At the position corresponding to the opening 9 in the substrate 1A, the mounting concave surface 14 of the calibration liquid container 13 is formed. FIG. 5 is an enlarged view of a portion corresponding to the mounting concave surface 14 of the calibration liquid container 13 and the substrate 1B. As shown in the drawing, the calibration liquid container 13 is made of a material having no gas permeability or a low material. Inside, a reagent for calibration of each detection unit in the sensor device 11 is hermetically accommodated. In this embodiment, the outer periphery 13a of the calibration liquid container is bonded at least so as not to be peeled off by the internal pressure when pressed by the pressing means of the analyzer described later. A discharge portion 13b is formed on the outer peripheral edge portion 13a, and a portion corresponding to the discharge portion 13b is formed of an easily peelable sealant so as to be peelable at least under an internal pressure when pressed by a pressing means of an analyzer described later. Glued. The peeling mechanism using the easily peelable sealant includes an interfacial peeling mechanism in which the sealant and the adherend are not completely fused and can be peeled with an appropriate strength, and can be peeled between the coating layer and the laminate film. A delamination mechanism or an agglomeration delamination mechanism that peels off due to internal cohesion and destruction of the sealant layer upon opening can be considered. By forming the calibration liquid container as described above, only the release section 13b is peeled off when pressed by the pressing means of the analyzer described later, so that the internal reagent can be released from the calibration liquid container. Become. In this way, the strength of the calibration liquid container is reduced compared to a detector that uses a structure in which the calibration liquid container is broken with a needle-shaped object to release the calibration liquid by forming the discharge part using the easily peelable sealant. As a whole, it can be made higher, and as a result, a material having low gas permeability can be used, so that the storage stability of the reagent when storing the detector is remarkably improved. In addition, a position corresponding to the free end of the narrow groove 6 which constitutes a part of the calibration liquid passage on one substrate 1A from the portion corresponding to the discharge portion 13b of the calibration liquid container 13 of the mounting concave surface 14 on the substrate 1B. The narrow groove 16 which forms a part of the calibration liquid passage is formed by the above. The narrow groove 16 communicates with the narrow groove 6 formed on one of the substrates 1A through a hole 23 provided in the partition plate 1C when assembled, thereby forming a single calibration liquid passage to form the calibration liquid. The calibrating liquid container 13 is pressed by the pressing means of the analyzer to make the discharge portion 13b of the liquid container 13 communicate with the test liquid passage 2 and to calibrate each detecting portion of the sensor device 11 prior to the measurement of the test liquid. When the discharge part 13b is peeled off, the calibration liquid in the calibration liquid container 13 flows to the detection part contact part 2b in the test liquid passage 2. Although not shown in detail in the drawings, the calibration liquid container mounting concave surface 14, the narrow groove 16 forming a part of the calibration liquid passage, and the calibration liquid container 13 receive reagents from the release portion 13 b of the calibration liquid container 13. It goes without saying that various configurations such as providing a guide groove to ensure that the reagent flows into the narrow groove 16 without leaking to other portions when the reagent is discharged are adopted.

Reference numeral 17 denotes a second waste liquid portion formed of a zigzag groove symmetrically formed with the waste liquid portion 4 at a position corresponding to the first waste liquid portion 4 on one substrate 1A. The waste liquid portion 17 communicates with a first waste liquid portion 4 formed on one of the substrates 1A through a hole 24 provided in the partition plate 1C when assembled, and forms one continuous waste liquid passage. (See FIG. 3). Further, at the downstream end of the waste liquid portion 17, an exhaust hole 18 communicating with the outside is formed, and as shown in FIG. 6, the exhaust hole 18 is permeable to air and not to liquid. A plug member 19 that functions as a transmissive member is mounted (FIG. 6 shows a partial cross-sectional view of the exhaust hole 18 in the substrate 1B). The plug member 19 is made of, for example, a porous synthetic resin made of a water-repellent material and containing a water-absorbent resin having a high water-absorbing rate in the pores thereof. When the liquid is injected, when the test liquid reaches the plug member 19, the water-absorbing resin absorbs the test liquid and expands to close each hole of the porous synthetic resin. Is closed, and the test liquid can no longer be injected with the injector. This ensures that the inside of the test liquid passage 2 from the injection hole 3 to the exhaust hole 18 is filled with the test liquid, so that the detection section of the sensor device 11 provided between the injection hole 3 and the exhaust hole 18 The test liquid is reliably supplied.

FIG. 7 is a schematic enlarged view of the sensor device 11. As shown in the drawing, the sensor device 11 includes a plurality of detection units 11b having electrodes formed by applying conductive ink on an insulating substrate 11a. The detection unit 11b includes: an acidity PH, a carbon dioxide partial pressure PCO2, an oxygen partial pressure PO2, sodium Na, potassium K, chlorine Cl, ionized calcium Ca, urea nitrogen B UN, glucose Glu, hematocrit Hct, bicarbonate ion HCO3- Depending on the components to be detected, such as oxygen saturation SO2, total carbon dioxide TCO2, excess base BE, hemoglobin Hgb, etc., the gas component to be detected passes through the portion corresponding to the test solution passage 2 of each electrode. A possible gas permeable membrane and a reagent layer formed by coating a chemical substance or a natural substance that reacts with the component to be detected can be appropriately provided. The detecting unit 11b further includes a counter electrode when a current detection method is used to measure the oxygen partial pressure or glucose concentration in blood, and further includes, for example, hydrogen, sodium or potassium in the test solution. If a potential difference detection method is used to measure the ion concentration of the sample, a reference electrode is further provided, and if the conductivity in the test solution is measured to measure the amount of hematocrit, a reference electrode is used. It can take various forms depending on the component to be detected, such as applying an AC voltage to the rectifier. In the illustrated embodiment, the detectors 11b are arranged so as to be able to measure eight types of inspection values among these inspection values. Each of the detecting portions 11b is connected to terminals 11e arranged along one side edge of the substrate 11a via a conductor 11d formed by applying conductive ink, and these terminals 11e are connected to the housing 1d. Are arranged so as to be exposed to the outside from the substrate 1A when assembled. That is, FIG. 8 is a schematic perspective view showing a state where the housing 1 is assembled. As can be seen from this drawing, the width of one substrate 1A is slightly smaller than that of the other substrate 1B, and the terminals 11e are two When the two substrates 1A and 1B are superimposed, they are arranged on portions of the substrate 1B that protrude from the substrate 1A. The insulating substrate may be made of any insulating material, such as ceramic, glass, glass epoxy, plastic, etc., as long as it is not damaged by the test solution. Plastic films such as vinyl, polyester, polyethylene, and polypropylene are preferable. Further, as a printing method for applying the conductive ink, preferably, a screen printing method capable of efficiently forming a large amount of a uniform material can be considered, but the printing method is not limited thereto, and the ink jet method, the nozzle coating method, and the dispenser may be used. Any method such as printing or casting can be used.

A through-hole 20 is provided at a position on the other substrate 1B corresponding to the through-hole 10 in one of the substrates 1A. When the two substrates 1A and 1B are bonded to each other, the through-holes 10 and 20 are formed. Are aligned and matched.

The partition plate 1C is provided with a plurality of openings 21 at positions along the detecting portion abutting portion 2b and the branch passage 7 of the test liquid passage 2 on the one substrate 1A. The test liquid flowing into the detection portion contact portion 2b and the branch passage 7 is made to come into contact with the detection portions 11c and the electrodes 11b on the other substrate 1B through these openings 21. Further, the partition plate 1C is provided with a hole 22 provided at a position corresponding to the through hole 10 in the one substrate 1A and the through hole 20 on the other substrate 1B, a free end of the narrow groove 6 of the one substrate 1A and the other substrate. The hole 23 for communicating with the free end of the narrow groove 16 of 1B to form one calibration liquid passage, and the waste liquid part 4 of one substrate 1A and the waste liquid part 17 of the other substrate 1B are communicated. A hole 24 for forming a continuous waste liquid portion is provided.

FIG. 9 is a schematic perspective view of a portable analyzer as an embodiment of a test solution analyzer that can use the detector according to the present invention, and FIG. 10 schematically shows internal processing of the analyzer. It is a block diagram. The portable analyzer includes an insertion slot 30 into which the card-type disposable detector illustrated in FIGS. 2 to 8 is inserted, an arithmetic processing unit 31 that performs arithmetic processing on output signals detected by each detection unit in the card-type disposable detector. A storage unit 32 for storing the calculation result of the calculation processing unit 31; a display unit 33 arranged on the upper surface of the casing for displaying data of the calculation result of the calculation processing unit 31; And a printer 34 for printing the data. The operation unit of the apparatus is incorporated in the display unit 33 shown in FIG. 9, and the calibration liquid container pressing means is provided inside the apparatus. The calibration liquid container pressing means is a card-type disposable detector. It can be operated by inserting it.

The operation of the analyzer and the detector configured as described above will be described with reference to a patient's blood analysis as an example. First, the prepared card-type disposable detector is inserted into the insertion port 30 of the portable analyzer, and calibration measurement of the detection unit of the sensor device is performed. That is, by inserting the card-type disposable detector, the measurement item is determined, the reagent container pressing means in the portable analyzer is automatically activated, and passes through the opening 9 formed in the substrate 1A of the detector. The calibration liquid container 13 is pressed at a predetermined pressure. As a result, the release portion 13b of the calibration solution container 13 is peeled off, and the calibration solution contained therein is released into the calibration solution passages 6, 16, and the test solution passage 2 is detected via the calibration solution passages 6, 16. The calibration liquid is caused to flow to the unit contact portion 2b, and comes into contact with the detection portion 11b. At this time, the analyzer performs calibration for each detector 11b based on the current value, voltage value, and the like detected from each terminal 11e.

Thereafter, the nozzle of the syringe containing the blood collected from the patient is fitted into the injection hole 3 of the card-type disposable detector, and the blood is injected into the internal test solution passage 2. At this time, since the test liquid passage 2 has a relatively narrow portion 2a on the upstream side of the detecting portion abutting portion 2b and a constricted portion 2c on the downstream side, the blood injection pressure varies. However, the infused blood slowly and stably flows along the detecting portion abutment portion 2b of the test liquid passage 2, and the detecting portion of each sensor device stably and accurately detects a desired test value. can do. Thus, the blood fluid that has passed through the detection portion abutment portion 2b of the test liquid passage 2 flows from the constricted portion 2c to the first waste liquid portion 4 through the downstream portion 2d. In this case, during the injection of blood by the syringe, the amount of injected blood can be easily recognized by monitoring the state of accumulation of blood in the first waste liquid section 4 from outside. Further, the downstream end of the second waste liquid section 17 connected to the first waste liquid section 4, that is, the exhaust hole 18 formed at the downstream end of the test liquid passage 2, is permeable to air and is liquid-permeable. Since the impervious plug member 19 is mounted on the test sample, even if the blood is injected into the plug member 19 and the test liquid passage 2 becomes full, even if the amount of special blood to be injected is not carefully monitored. The plug member 19 closes the exhaust port 18 so that no more blood can be automatically injected. Unlike the conventional method, in which the injected blood is held in the test device and the calibration operation is performed, and then the test value of the blood held in the test device is measured, unlike the conventional method, the blood injected into the test device is used in the present invention. Since blood measurement values are measured substantially simultaneously with the injection, accurate measurement values can be obtained.

The current value and the voltage value detected by each of the detection units 11b are sent from a terminal 11e to an arithmetic processing unit 31 in the portable analyzer, where they are subjected to arithmetic processing, and are subjected to the acidity PH and the carbon dioxide gas content. Pressure PCO2, oxygen partial pressure PO2, sodium Na, potassium K, chlorine Cl, calcium ion Ca, urea nitrogen BUN, glucose Glu, hematocrit Hct, bicarbonate ion HCO3-, oxygen saturation SO2, total carbon dioxide TCO2, Data relating to various gas concentrations and ion concentrations such as excess base BE and hemoglobin Hgb are output. On the one hand, these data are stored in the storage unit 33 and displayed on the display unit 33 disposed on the upper surface of the casing. Is displayed. These data can be printed out by operating the printer 34 if necessary.

In the illustrated embodiment, the housing 1 is composed of the two substrates 1A and 1B and the partition plate 1C. However, the present invention is not limited to this embodiment, and a configuration in which a test liquid passage can be formed inside. Then, any configuration can be considered. In the illustrated embodiment, the two substrates are entirely made of a transparent or translucent material. However, the present invention is not limited to this embodiment and may be made of an opaque material. Part of the first and second waste liquid portions 4 and 17 may be made of a transparent material so that the state can be confirmed. Further, in this embodiment, the terminals of the sensor device are exposed by forming one substrate to be narrower than the other substrate. You may comprise so that it may be exposed. Further, in the illustrated embodiment, the two substrates are bonded by a partition plate having an adhesive layer on both surfaces, but this is not limited to the present embodiment, and the two substrates can be directly bonded by an adhesive. Good. Further, although the sensor device is provided separately from the housing, a detection unit or the like may be provided directly on the housing. Furthermore, the number of detection units can be arbitrarily set according to the number and type of test values.

[0020]

[Effect of the invention]

 The disposable component detector according to the present invention includes a test solution passage capable of supplying a test solution to be analyzed inside a housing, and a sensor device capable of detecting at least one component of the test solution supplied to the test solution passage. A calibration liquid container containing a reagent capable of calibrating the detection unit of the sensor device, the detection unit being provided so as to be exposed in the test liquid passage, and the terminal unit being exposed to the outside of the housing. An easy-peeling release part capable of being peeled off at a predetermined pressure on at least a part of the calibration liquid container, and releasing the calibration liquid container at least upstream of the detection unit of the sensor device in the test liquid passage. And a terminal that can be detachably connected to an analyzer that can analyze at least one component in the test solution based on the detection result of the detection unit. Therefore, the balance between the storability and the usability of the calibration solution, which was found in the conventional component detector that was configured to release the calibration solution by making a hole in the calibration solution container with a needle-shaped member, was used. The problem has been solved, and the calibration solution container can be manufactured simply considering the storage stability of the calibration solution.This has the effect of ensuring that the calibration process can be performed with a calibration solution with good storage stability. This has the effect of improving the analysis accuracy of the device. In addition, by providing a test liquid injection hole in the test liquid passage upstream of the test liquid passage and providing an exhaust hole in the downstream portion, the test liquid can be directly injected into the sensor device in the test passage. There is no need to provide a part for temporarily holding the test liquid or a mechanism for sending the held test liquid to the detection unit, and the effect of simplifying not only the detection tool itself but also the configuration of an analyzer using the detection tool is achieved. In this case, if the exhaust hole is provided with a material that is permeable to air and impermeable to liquid, for example, a water-repellent porous synthetic resin body containing a water-absorbing synthetic resin, the test liquid When the water reaches the plug member at the downstream end of the test liquid passage, the water-absorbing synthetic resin absorbs the test liquid and expands, closing each hole of the porous synthetic resin body, and automatically closing the exhaust hole. Since the test solution cannot be injected any more, the operator does not need to pay special attention to the injection amount when injecting, and the work load is reduced. Further, a waste liquid portion having a volume capable of storing a predetermined amount of the test liquid is provided at least downstream of the sensor device in the test liquid passage, and the exhaust hole is provided in the waste liquid portion, so that the test liquid to be inspected is provided. The flexibility with respect to the variation of the injection amount can be increased, and the operability and the workability can be facilitated. Furthermore, the injection hole for the test solution is inserted into the nozzle portion of the test solution injector so that the nozzle portion can be fitted in a liquid-tight manner. For example, when the test solution injector is a syringe, the nozzle portion conforms to the JIS standard. If the taper is formed in accordance with the size and shape, the test solution can be injected without touching the atmosphere when the test solution is injected, so that the influence of the atmosphere on the measured values can be avoided and the reliability of the detection data can be improved. Performance can be greatly improved.

[Brief description of the drawings]

FIG. 1 is a schematic top view of a disposable component detector (hereinafter simply referred to as a detector) for a test liquid analyzer according to an embodiment of the present invention.

FIG. 2 is a schematic development view of the detection tool according to the present invention.

FIG. 3 is a schematic top view of a test liquid passage in the detection tool after the housing is assembled.

FIG. 4 is a partial cross-sectional view of a portion corresponding to the injection hole 3 in the base 1A.

FIG. 5 is an enlarged view of a portion corresponding to the mounting concave surface 14 in the calibration liquid container 13 and the substrate 1B.

FIG. 6 is a partial sectional view of an exhaust hole portion of a substrate 1B.

FIG. 7 is a schematic enlarged view of the sensor device 11;

FIG. 8 is a schematic perspective view showing a state where the housing 1 is assembled.

FIG. 9 is a schematic perspective view showing an embodiment of a portable analyzer that can use the detector according to the present invention.

10 is a block diagram showing a configuration of the portable analyzer shown in FIG.

[Explanation of symbols]

 REFERENCE SIGNS LIST 100 housing 101 test liquid passage 102 test liquid supply unit 103 sensor device 104 calibration liquid supply passage 105 calibration liquid container 1 housing 1A substrate 1B substrate 1C partition plate 2 test liquid passage 2a relatively narrow portion 2b extending from injection hole 3 detection Part abutting part 2c Narrowed part 2d Part extending from narrowed part 2c to first waste liquid part 4 3 Injection hole 4 Waste liquid part 6 Narrow groove forming a part of calibration liquid passage 7 Branch passage 8 Through hole 9 Opening for pressing DESCRIPTION OF SYMBOLS 10 Through-hole 11 Sensor device 11a Substrate 11b Detecting part 11d Conductor 11e Terminal 12 Concave surface 13 Calibration liquid container 13a Outer peripheral edge 13b Discharge part 14 Calibration liquid container mounting concave surface 16 Narrow groove constituting a part of calibration liquid passage 17 Second Waste liquid portion 18 Exhaust hole 19 Plug member 20 Through hole 21 Opening 22 Through hole 23 Hole communicating with narrow grooves 6 and 16 4 first drainage member 4 and the hole 30 insertion opening 31 processing unit 32 storage unit 33 display unit 34 the printer for communicating the second waste fluid section 17

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification code Agency reference number FI Technical indication location G01N 27/46 371G

Claims (5)

[Utility model registration claims] 1. A sensor device having a test liquid passage capable of supplying a test liquid to be analyzed inside a housing and capable of detecting at least one component of the test liquid supplied to the test liquid passage. A calibration liquid container is provided which is exposed in the test liquid passage, and is provided so that a terminal portion thereof is exposed to the outside of the housing. At least a part of the test solution passage is provided with an easy-peeling release portion that can be peeled off at a predetermined pressure, and the calibration liquid container is arranged at a position at which a reagent can be discharged at least in the test solution passage on the upstream side of the detection portion of the sensor device. The terminal unit is configured to be connectable to an analyzer capable of analyzing at least one component in a test solution based on a detection result of the detection unit. Discarded component detection device. 2. A test liquid injection hole is provided in an upstream portion of the test liquid passage, and an exhaust hole is provided in a downstream portion. The exhaust hole is permeable to air and impermeable to liquid. The component detector according to claim 1, further comprising a plug member made of the material described in (1). 3. The component detector according to claim 2, wherein the plug member is formed of a water-repellent porous synthetic resin body containing a water-absorbing synthetic resin. 4. The method according to claim 1, wherein the test liquid passage includes a waste liquid portion having a volume capable of storing a predetermined amount of the test liquid at least downstream of the sensor device, and the exhaust hole is provided in the waste liquid portion. The component detector according to claim 2 or 3, wherein 5. The component detector according to claim 2, wherein the test liquid injection hole is configured such that a nozzle portion of the test liquid injector can be fitted in a liquid-tight manner.