JPH07136120A - Ophthalmologic apparatus - Google Patents
Ophthalmologic apparatusInfo
- Publication number
- JPH07136120A JPH07136120A JP5281563A JP28156393A JPH07136120A JP H07136120 A JPH07136120 A JP H07136120A JP 5281563 A JP5281563 A JP 5281563A JP 28156393 A JP28156393 A JP 28156393A JP H07136120 A JPH07136120 A JP H07136120A
- Authority
- JP
- Japan
- Prior art keywords
- lipid layer
- interference pattern
- eye
- color image
- light
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Eye Examination Apparatus (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は眼科装置に関し、特に被
検眼の涙液最表層の脂質層を観察することにより、ドラ
イアイの進捗度を簡易に定性的に診断することのできる
眼科装置に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an ophthalmologic apparatus, and more particularly to an ophthalmologic apparatus capable of qualitatively diagnosing the progress of dry eye easily by observing the outermost lipid layer of the tear fluid of the eye to be examined. It is a thing.
【０００２】[0002]
【従来の技術】近年、ＶＤＴ（visual display termina
l）作業者の増加や冷暖房による部屋の乾燥などにより
ドライアイ患者が増加している。ドライアイになると角
膜上皮障害や結膜障害、その他にも種々の眼科疾患を併
発するおそれがあり、ドライアイの診断は眼科診断の上
で重要である。2. Description of the Related Art In recent years, VDT (visual display termina)
l) The number of dry eye patients is increasing due to the increase of workers and the drying of rooms by air conditioning. Since dry eye may cause corneal epithelial disorder, conjunctival disorder, and various other ophthalmic diseases, the diagnosis of dry eye is important for ophthalmic diagnosis.
【０００３】従来は、生体染色検査（ローズベンガル
法、フルオレセイン法）、涙液量検査（シルマーテス
ト、綿糸法、ＢＵＴ、クリアランステスト）などにより
ドライアイの診断を行なっていたが、薬物点眼や異物接
触を伴うため被検者の苦痛は避けられなかった。そこ
で、特開昭６２−２２２１４３号（この特許は実際には
コンタクトレンズの水漏れ性の測定に関するものであ
る）のように被検眼にコヒーレント光を照射して涙液層
での干渉縞を観察する方法などが試みられている。Conventionally, the diagnosis of dry eye has been performed by a vital stain test (Rose Bengal method, fluorescein method), a tear volume test (Schirmer test, cotton thread method, BUT, clearance test), etc. The suffering of the subject was unavoidable because of the contact. Therefore, as in JP-A-62-222143 (this patent actually relates to the measurement of water leakage of contact lenses), the eye to be examined is irradiated with coherent light to observe interference fringes in the tear film. The method of doing is being tried.
【０００４】[0004]
【発明が解決しようとする課題】ところが、上記のコヒ
ーレント光による方法以外の従来の方法では被検者への
負担が大きく、また局所的なドライアイの診断は難しか
った。また、コヒーレント光による干渉縞を観察する方
法では、確かに非接触で、しかも局所的な診断も可能で
あるが、コヒーレント光を作る為にレーザー光源や狭帯
域の干渉フィルターなどの高価な部品が必要となり、ど
うしても装置の大型化やコストアップにつながってしま
うという欠点があった。However, the conventional method other than the above-mentioned method using coherent light imposes a heavy burden on the subject and makes it difficult to locally diagnose dry eye. In addition, the method of observing the interference fringes by the coherent light certainly enables non-contact and local diagnosis, but expensive components such as a laser light source and a narrow band interference filter are used to make the coherent light. It was necessary, and there was a drawback that it would inevitably lead to an increase in size and cost of the device.
【０００５】そこで本発明の課題は、以上の問題を解決
し、非接触で局所的なドライアイの簡易的診断を容易に
行なうことができ、しかも簡単安価に構成可能な眼科装
置を提供することにある。Therefore, an object of the present invention is to solve the above problems, and to provide an ophthalmologic apparatus capable of easily performing non-contact and local diagnosis of dry eye easily and which can be constructed easily and inexpensively. It is in.
【０００６】[0006]
【課題を解決するための手段】上記の課題を解決するた
め、本発明の眼科装置によれば、被検眼を照明するため
の白色光源と、前記白色光源からの光を被検眼涙液最表
層の脂質層の所定点に導く投光光学系と、前記脂質層の
所定点からの反射光を受光し、前記脂質層の表面と裏面
の反射光の干渉による干渉模様のカラー画像を光電変換
素子により光電変換する受光光学系と、前記光電変換素
子の出力により前記干渉模様のカラー画像を表示する表
示手段とを備え、前記表示手段に表示される前記干渉模
様のカラー画像を観察することにより、前記脂質層の状
態を知ることができ、ドライアイの診断を行なえるよう
にした構成を採用した。In order to solve the above problems, according to the ophthalmologic apparatus of the present invention, a white light source for illuminating the eye to be inspected, and the light from the white light source is the outermost surface layer of the tear fluid to be inspected. And a light projecting optical system that guides the light to a predetermined point of the lipid layer, and receives reflected light from the predetermined point of the lipid layer, and photoelectrically converts a color image of an interference pattern due to interference of reflected light on the front surface and the back surface of the lipid layer. By a light receiving optical system for photoelectric conversion by, and display means for displaying a color image of the interference pattern by the output of the photoelectric conversion element, by observing the color image of the interference pattern displayed on the display means, The constitution is adopted so that the condition of the lipid layer can be known and dry eye can be diagnosed.
【０００７】[0007]
【作用】このような構成によれば、被検眼涙液最表層の
脂質層からの反射光（白色光）の干渉模様（虹色に変化
するカラーの干渉模様）のカラー画像が受光光学系の光
電変換素子により光電変換され、その干渉模様のカラー
画像が表示手段に表示され、検者はそれを観察すること
ができる。この干渉模様は脂質層の状態、即ち脂質層の
有無の程度、つまり厚み（０．１〜０．２μｍ）とその
変化、涙液の流れていく様子、及び涙液の粘性などを反
映しており、この干渉模様を観察することで脂質層の状
態を知り、ドライアイの簡易的診断を行なうことができ
る。With this structure, a color image of the interference pattern of reflected light (white light) from the outermost lipid layer of the tear fluid of the eye to be inspected (interference pattern of color changing to rainbow color) of the receiving optical system is obtained. The color image of the interference pattern is photoelectrically converted by the photoelectric conversion element and is displayed on the display unit so that the examiner can observe it. This interference pattern reflects the state of the lipid layer, that is, the degree of the presence or absence of the lipid layer, that is, the thickness (0.1 to 0.2 μm) and its change, the flow of tear fluid, and the viscosity of tear fluid. Therefore, by observing this interference pattern, the state of the lipid layer can be known, and a simple diagnosis of dry eye can be performed.
【０００８】例えば、ドライアイになってくると、脂質
層が薄くなっていく（供給が少なくなっていくため）傾
向にあり、干渉模様が見られなくなっていく。また、涙
液の流れていく様子は干渉模様の移動距離や移動速度、
色の変化速度により知ることができるが、その流れはド
ライアイの進行と供に悪くなっていき、涙液の粘性につ
いてはドライアイと供に高くなっていく傾向にある。こ
の様に、干渉模様を観察することでドライアイの進行状
況の色々な状態を知る事が出来る。[0008] For example, as dry eyes tend to appear, the lipid layer tends to become thinner (because the supply decreases), and the interference pattern disappears. Also, how tears flow is the movement distance and movement speed of the interference pattern,
As can be seen from the rate of color change, the flow tends to worsen with the progress of dry eye, and the viscosity of tears tends to increase with dry eye. In this way, by observing the interference pattern, various states of the progress of the dry eye can be known.
【０００９】尚、干渉模様がカラーの干渉模様となって
いるので、この模様の変化は色彩的変化としても捕らえ
る事が可能であり、検者にとっては非常に変化が見やす
くなる。Since the interference pattern is a color interference pattern, the change in the pattern can be grasped as a color change, which is very easy for the examiner to see.
【００１０】[0010]
【実施例】以下、図を参照して本発明の実施例を説明す
る。Embodiments of the present invention will be described below with reference to the drawings.
【００１１】図１は実施例の眼科装置の概略構成を示
し、図２は同装置の外観を示している。FIG. 1 shows a schematic structure of an ophthalmologic apparatus according to an embodiment, and FIG. 2 shows an appearance of the apparatus.
【００１２】図１において、符号１で図示するものは、
被検眼Ｅを照明するための白色光源でハロゲンランプ等
によって構成される。白色光源１から射出された光は、
照明視野を制限する視野絞り２を通過後、レンズ３、ハ
ーフミラー４、レンズ５を介して被検眼Ｅ上の所定点Ｐ
を照明する。点Ｐの位置は被検眼Ｅの角膜上の涙液最表
層の脂質層に選択される。In FIG. 1, what is indicated by reference numeral 1 is
It is a white light source for illuminating the eye E to be inspected and is composed of a halogen lamp or the like. The light emitted from the white light source 1 is
After passing through the field stop 2 that limits the illumination field, a predetermined point P on the eye E to be examined is passed through the lens 3, the half mirror 4, and the lens 5.
Illuminate. The position of the point P is selected as the outermost lipid layer of the tear fluid on the cornea of the eye E to be examined.
【００１３】なおハーフミラー４を介して、点Ｐへの投
光を行なう投光光学系と、後で述べる受光光学系の一部
を共有することにより、装置全体のコンパクト化、低コ
スト化を実現している。また、白色光源１は電源回路ボ
ックス１２内に備えられた調光回路（不図示）により光
量が調節できるようになっており、この操作は図２に示
した架台１３上の調光ボタン１４により行われる。By sharing a part of a light-receiving optical system, which will be described later, with a light-projecting optical system for projecting light to the point P via the half mirror 4, it is possible to reduce the size and cost of the entire apparatus. Has been realized. Further, the white light source 1 can be adjusted in light quantity by a light control circuit (not shown) provided in the power supply circuit box 12, and this operation is performed by a light control button 14 on the pedestal 13 shown in FIG. Done.
【００１４】点Ｐからの反射光（涙液最表層の脂質層の
表面及び裏面での反射光）は脂質層の厚みその他の状態
により種々の干渉模様を形成する。この干渉模様を形成
する反射光はレンズ５、ハーフミラー４、レンズ６を介
してＣＣＤカメラ用電源８により駆動されるカラーＣＣ
Ｄカメラ７に受光され、干渉模様のカラー画像がＣＣＤ
カメラ７により光電変換され、その出力により干渉模様
のカラー画像がモニター９に表示され、検者に観察され
る。また、モニター９に表示される干渉模様のカラー画
像はビデオテープレコーダー１０によって記録される。
また、必要に応じて干渉模様のカラー画像のハードコピ
ーが撮れるように、ビデオテープレコーダー１０にビデ
オプリンター１１を接続しておくとよい。なお、干渉模
様のカラー画像を記録する記録手段としてビデオテープ
レコーダーを選んだのは非常に手軽で安価なためであ
る。本装置は簡易診断装置であるため低コストが最優先
される。Reflected light from the point P (reflected light on the front and back surfaces of the outermost lipid layer of the tear fluid) forms various interference patterns depending on the thickness of the lipid layer and other conditions. The reflected light that forms the interference pattern passes through the lens 5, the half mirror 4, and the lens 6 and is driven by the CCD camera power source 8 to generate a color CC.
The color image of the interference pattern received by the D camera 7 is CCD
Photoelectric conversion is performed by the camera 7, and a color image having an interference pattern is displayed on the monitor 9 by the output and is observed by the examiner. The color image of the interference pattern displayed on the monitor 9 is recorded by the video tape recorder 10.
Further, a video printer 11 may be connected to the video tape recorder 10 so that a hard copy of a color image having an interference pattern can be taken as needed. The video tape recorder was selected as the recording means for recording the color image of the interference pattern because it is very convenient and inexpensive. Since this device is a simple diagnostic device, low cost is given top priority.
【００１５】また、図２に示すように、本装置では、発
光ダイオードからなる固視灯１７が被検者の固視できる
位置に配置される。この固視灯１７はリンク機構１８に
よって自由に移動させることができ、被検者に対して最
適な位置に調節することができるようになっている。Further, as shown in FIG. 2, in the present apparatus, a fixation lamp 17 composed of a light emitting diode is arranged at a position where the examinee can fix it. The fixation lamp 17 can be freely moved by a link mechanism 18 and can be adjusted to an optimum position for the subject.
【００１６】更に、固視灯１７で誘導しにくい被検者に
対しては、装置本体２０が回転軸１９を中心に水平面内
に回動できるため、これら２つの機能により被検眼上の
どこでも観察できるようになっている。Further, for the subject who is difficult to be guided by the fixation lamp 17, the device main body 20 can be rotated in the horizontal plane about the rotation axis 19, so that these two functions allow observation anywhere on the subject's eye. You can do it.
【００１７】次に、装置と被検眼のアライメント手順お
よび観察手順について説明する。Next, the alignment procedure between the device and the eye to be inspected and the observation procedure will be described.
【００１８】まず、被検眼照明用の白色光源１を点灯
し、被検者のあごをあご台１６に乗せ、観察部位に応じ
て装置本体２０を被検眼Ｅに対して適当な位置に設定す
る。通常は被検眼正面に設定する。その後、ジョイステ
ィック１５を操作して装置本体２０を微動させ、図３に
示すように、被検眼角膜上の涙液層の最表層である脂質
層の表面と裏面からの反射光がレンズ６を介してカラー
ＣＣＤカメラ７のＣＣＤ受光面７ａに来るようにし、脂
質層の表面と裏面の反射光がコントラストよく干渉模様
を形成するように微調を行ない、ビデオテープレコーダ
ー１０の録画スイッチをオンにして記録を始める。尚、
ビデオの録画はアライメントを始める前から入れておい
て後で不要の部分を消去してもよい。ここで、被検者に
対して瞬きを促すようにすると干渉模様の変化がとらえ
易くなる。First, the white light source 1 for illuminating the eye to be inspected is turned on, the chin of the person to be inspected is placed on the chin table 16, and the apparatus main body 20 is set at an appropriate position with respect to the eye to be inspected E according to the observation site. . Normally, it is set in front of the eye to be examined. Then, the joystick 15 is operated to finely move the device body 20, and as shown in FIG. 3, reflected light from the front and back surfaces of the lipid layer, which is the outermost layer of the tear film on the cornea of the eye, passes through the lens 6. To the CCD light-receiving surface 7a of the color CCD camera 7, fine adjustment is performed so that the reflected light from the front and back surfaces of the lipid layer forms an interference pattern with good contrast, and the recording switch of the video tape recorder 10 is turned on for recording. To start. still,
The video may be recorded before starting the alignment and the unnecessary portions may be deleted afterwards. Here, if the subject is prompted to blink, the change in the interference pattern can be easily captured.
【００１９】そして、必要な時間録画したら録画スイッ
チをオフにして観察を終える。この操作を必要に応じて
点Ｐの位置を変えて繰り返し行なう。全ての観察が終了
したら白色光源１のスイッチを切って観察を終了する。After recording for the required time, the recording switch is turned off to finish the observation. This operation is repeated by changing the position of the point P as necessary. When all the observations have been completed, the white light source 1 is switched off and the observations are completed.
【００２０】次に、観察した結果について説明する。図
４において、（Ａ）には健常者の干渉模様を、（Ｂ）に
はドライアイの患者の干渉模様の例を示す。健常者では
涙液最表層の脂質層が十分にあるため虹色のカラーの干
渉模様がコントラストよく観察することができる。ま
た、瞬きによる模様の変化もよく判り、涙液が流れてい
く様子もよく判る。これに対して、ドライアイの患者は
脂質層が薄くなっており、干渉模様がはっきりしなかっ
たり、仮にはっきりしていても瞬きによる模様の変化や
涙液の動きが鈍く健常者との差別化が可能である。Next, the observation results will be described. In FIG. 4, (A) shows an interference pattern of a healthy person, and (B) shows an example of an interference pattern of a dry eye patient. In a healthy person, since the outermost lipid layer of the tear fluid is sufficient, an interference pattern of rainbow colors can be observed with good contrast. In addition, the change in the pattern due to blinking can be seen well, and the way tears are flowing can be seen well. On the other hand, in patients with dry eye, the lipid layer is thin, and the interference pattern is not clear, and even if it is clear, the pattern change due to blinking and the movement of tear fluid are slow, and it differentiates from healthy subjects. Is possible.
【００２１】この様にして、干渉模様の観察により脂質
層の有無の程度、厚みとその変化、及び涙液の流れの様
子などを知ることができ、それによりドライアイの進行
状況の様々な状態を知ることができ、非接触で局所的な
ドライアイの簡易的診断を行なうことができる。しかも
干渉模様が白色光による虹色のカラーの干渉模様である
ので、干渉模様の変化が濃淡だけでなく色彩の変化とし
てもとらえることができるため、非常に見易く、ドライ
アイの簡易的診断をより容易に行なえる。また、コヒー
レント光源を用いる場合に比べ、コスト的にも非常に安
価であるという利点がある。In this way, by observing the interference pattern, it is possible to know the degree of presence or absence of the lipid layer, the thickness and its change, and the state of the flow of tear fluid, and thereby various states of the progress of the dry eye. Therefore, it is possible to carry out a simple non-contact local diagnosis of dry eye. Moreover, since the interference pattern is a rainbow color interference pattern due to white light, changes in the interference pattern can be captured as changes in color as well as in shades, making it very easy to see and making a simple diagnosis of dry eye easier. Easy to do. Further, there is an advantage that the cost is very low as compared with the case of using the coherent light source.
【００２２】なお本実施例の装置では、干渉模様のカラ
ー画像を記録するビデオテープレコーダー１０を備えて
いるので、それにより記録した干渉模様を観察後にモニ
ター９に表示して検者が被検者に説明することもでき
る。また、過去に採った干渉模様のデータを見直すこと
も簡単にできる。Since the apparatus of the present embodiment is equipped with the video tape recorder 10 for recording the color image of the interference pattern, the recorded interference pattern is displayed on the monitor 9 after the observation, and the examiner examines it. Can also be explained. Also, it is possible to easily review the data of the interference pattern taken in the past.
【００２３】[0023]
【発明の効果】以上の説明から明らかなように、本発明
の眼科装置によれば、被検眼涙液最表層の脂質層の所定
点に白色光を投光し、この所定点からの反射光を受光
し、脂質層の表面と裏面の反射光の干渉による干渉模様
のカラー画像を表示手段に表示し、この表示手段に表示
される干渉模様のカラー画像を観察することにより、脂
質層の状態を知ることができ、ドライアイの診断を行な
えるようにした構成を採用したので、干渉模様の観察に
よりドライアイの進行状況の様々な状態を知ることがで
き、しかも干渉模様がカラーのため模様の変化が非常に
見易く、非接触で局所的なドライアイの簡易的診断を容
易に行なうことができる。しかも簡単安価に構成できる
という優れた効果が得られる。As is apparent from the above description, according to the ophthalmologic apparatus of the present invention, white light is projected onto a predetermined point of the lipid layer which is the outermost surface of the tear fluid of the eye to be examined, and the reflected light from this predetermined point. The color image of the interference pattern due to the interference of the reflected light on the front surface and the back surface of the lipid layer is displayed on the display means, and the color image of the interference pattern displayed on the display means is observed to determine the state of the lipid layer. It is possible to know the state of the dry eye by observing the interference pattern because it adopts a configuration that allows the diagnosis of dry eye. Is very easy to see, and it is possible to easily make a non-contact and simple diagnosis of local dry eye. Moreover, an excellent effect that the structure can be configured easily and inexpensively is obtained.
【図１】本発明の眼科装置の実施例の構成を示した構成
図である。FIG. 1 is a configuration diagram showing a configuration of an embodiment of an ophthalmologic apparatus of the present invention.
【図２】同装置の外観を示した側面図である。FIG. 2 is a side view showing an appearance of the same device.
【図３】被検眼涙液最表層の脂質層での照明光の反射の
様子を示した説明図である。FIG. 3 is an explanatory diagram showing a state of reflection of illumination light on a lipid layer which is the outermost surface layer of tear fluid of the eye to be examined.
【図４】健常者の干渉模様とドライアイ患者の干渉模様
の記録例を示した説明図である。FIG. 4 is an explanatory diagram showing an example of recording an interference pattern of a healthy person and an interference pattern of a dry eye patient.
１ 白色光源 ２ 視野絞り ３，５，６ レンズ ４ ハーフミラー ７ カラーＣＣＤカメラ ９ モニター（ＣＲＴ） １０ ビデオテープレコーダー １２ 電源回路ボックス １３ 架台 １４ 調光ボタン １５ ジョイスティック １６ あご台 １７ 固視灯 Ｅ 被検眼 Ｐ 被検眼涙液最表層の脂質層の所定点 1 White Light Source 2 Field Stop 3, 5, 6 Lens 4 Half Mirror 7 Color CCD Camera 9 Monitor (CRT) 10 Video Tape Recorder 12 Power Circuit Box 13 Stand 14 Light Control Button 15 Joystick 16 Jaw Stand 17 Fixing Light E Eyes to be Inspected P Predetermined point on the outermost lipid layer of tear fluid
Claims (4)
定点に導く投光光学系と、 前記脂質層の所定点からの反射光を受光し、前記脂質層
の表面と裏面の反射光の干渉による干渉模様のカラー画
像を光電変換素子により光電変換する受光光学系と、 前記光電変換素子の出力により前記干渉模様のカラー画
像を表示する表示手段とを備え、 前記表示手段に表示される前記干渉模様のカラー画像を
観察することにより、前記脂質層の状態を知ることがで
き、ドライアイの診断を行なえるようにしたことを特徴
とする眼科装置。1. A white light source for illuminating an eye to be inspected, a projection optical system for guiding light from the white light source to a predetermined point of a lipid layer which is the outermost surface of tear fluid of an eye to be inspected, and a predetermined point of the lipid layer A light receiving optical system for receiving the reflected light of the lipid layer and photoelectrically converting a color image of the interference pattern by the interference of the reflected light of the front surface and the back surface of the lipid layer, and the color of the interference pattern by the output of the photoelectric conversion element. A display means for displaying an image is provided, and by observing the color image of the interference pattern displayed on the display means, the state of the lipid layer can be known and dry eye diagnosis can be performed. An ophthalmologic apparatus characterized by the above.
ミラーを介して一部を共有することを特徴とする請求項
１に記載の眼科装置。2. The ophthalmologic apparatus according to claim 1, wherein the light projecting optical system and the light receiving optical system share a part through a half mirror.
録手段を設けたことを特徴とする請求項１に記載の眼科
装置。3. The ophthalmologic apparatus according to claim 1, further comprising recording means for recording the color image of the interference pattern.
であることを特徴とする請求項３に記載の眼科装置。4. The ophthalmologic apparatus according to claim 3, wherein the recording means is a video tape recorder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5281563A JPH07136120A (en) | 1993-11-11 | 1993-11-11 | Ophthalmologic apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5281563A JPH07136120A (en) | 1993-11-11 | 1993-11-11 | Ophthalmologic apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH07136120A true JPH07136120A (en) | 1995-05-30 |
Family
ID=17640935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5281563A Pending JPH07136120A (en) | 1993-11-11 | 1993-11-11 | Ophthalmologic apparatus |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH07136120A (en) |
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6299305B1 (en) | 1999-02-18 | 2001-10-09 | Nidek Co., Ltd. | Ophthalmic apparatus |
| US6394603B2 (en) | 2000-03-22 | 2002-05-28 | Nidek Co., Ltd. | Ophthalmic apparatus |
| WO2007004383A1 (en) | 2005-07-01 | 2007-01-11 | Kowa Kabushiki Kaisha | Ophthalmologic photographing device |
| US7216980B2 (en) | 2001-02-09 | 2007-05-15 | Kabushiki Kaisha Topcon | Eye characteristic measuring apparatus |
| US7241012B2 (en) | 2003-01-21 | 2007-07-10 | Kabushiki Kaisha Topcon | Ophthalmologic apparatus |
| JP2007209370A (en) * | 2006-02-07 | 2007-08-23 | Norihiko Yokoi | Opthalmological device |
| JP2007260339A (en) * | 2006-03-30 | 2007-10-11 | Topcon Corp | Ophthalmological measurement device |
| JP2009178174A (en) * | 2008-01-29 | 2009-08-13 | Norihiko Yokoi | Ophthalmologic measuring apparatus |
| JP2010530282A (en) * | 2007-06-20 | 2010-09-09 | テイアサイエンス・インコーポレーテツド | Tear film measurement |
| JP2013056152A (en) * | 2011-08-30 | 2013-03-28 | Oculus Optikgeraete Gmbh | Ophthalmic analytical instrument and method |
| US8545017B2 (en) | 2009-04-01 | 2013-10-01 | Tearscience, Inc. | Ocular surface interferometry (OSI) methods for imaging, processing, and/or displaying an ocular tear film |
| US8585204B2 (en) | 2007-06-20 | 2013-11-19 | Tearscience, Inc. | Tear film measurement |
| US9339177B2 (en) | 2012-12-21 | 2016-05-17 | Tearscience, Inc. | Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography |
| US9642520B2 (en) | 2009-04-01 | 2017-05-09 | Tearscience, Inc. | Background reduction apparatuses and methods of ocular surface interferometry (OSI) employing polarization for imaging, processing, and/or displaying an ocular tear film |
| JP2017136212A (en) * | 2016-02-03 | 2017-08-10 | 株式会社ニデック | Ophthalmologic apparatus |
| US9795290B2 (en) | 2013-11-15 | 2017-10-24 | Tearscience, Inc. | Ocular tear film peak detection and stabilization detection systems and methods for determining tear film layer characteristics |
| US9888839B2 (en) | 2009-04-01 | 2018-02-13 | Tearscience, Inc. | Methods and apparatuses for determining contact lens intolerance in contact lens wearer patients based on dry eye tear film characteristic analysis and dry eye symptoms |
| US10278587B2 (en) | 2013-05-03 | 2019-05-07 | Tearscience, Inc. | Eyelid illumination systems and method for imaging meibomian glands for meibomian gland analysis |
| JP2019202187A (en) * | 2017-03-14 | 2019-11-28 | 株式会社トプコン | Tear film thickness measurement apparatus and method |
| WO2020111104A1 (en) * | 2018-11-27 | 2020-06-04 | 株式会社トプコン | Ophthalmological device |
| WO2020226082A1 (en) * | 2019-05-08 | 2020-11-12 | 株式会社トプコン | Ophthalmic device |
| US11185220B2 (en) | 2019-04-24 | 2021-11-30 | Topcon Corporation | Ophthalmologic apparatus |
| US11503995B2 (en) | 2019-04-24 | 2022-11-22 | Topcon Corporation | Ophthalmologic apparatus |
-
1993
- 1993-11-11 JP JP5281563A patent/JPH07136120A/en active Pending
Cited By (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6299305B1 (en) | 1999-02-18 | 2001-10-09 | Nidek Co., Ltd. | Ophthalmic apparatus |
| US6394603B2 (en) | 2000-03-22 | 2002-05-28 | Nidek Co., Ltd. | Ophthalmic apparatus |
| US7216980B2 (en) | 2001-02-09 | 2007-05-15 | Kabushiki Kaisha Topcon | Eye characteristic measuring apparatus |
| US7241012B2 (en) | 2003-01-21 | 2007-07-10 | Kabushiki Kaisha Topcon | Ophthalmologic apparatus |
| WO2007004383A1 (en) | 2005-07-01 | 2007-01-11 | Kowa Kabushiki Kaisha | Ophthalmologic photographing device |
| JP2007209370A (en) * | 2006-02-07 | 2007-08-23 | Norihiko Yokoi | Opthalmological device |
| US7677728B2 (en) | 2006-03-30 | 2010-03-16 | Kabuhsiki Kaisha Topcon | Ophthalmologic measuring apparatus |
| JP2007260339A (en) * | 2006-03-30 | 2007-10-11 | Topcon Corp | Ophthalmological measurement device |
| US8585204B2 (en) | 2007-06-20 | 2013-11-19 | Tearscience, Inc. | Tear film measurement |
| JP2010530282A (en) * | 2007-06-20 | 2010-09-09 | テイアサイエンス・インコーポレーテツド | Tear film measurement |
| JP2009178174A (en) * | 2008-01-29 | 2009-08-13 | Norihiko Yokoi | Ophthalmologic measuring apparatus |
| US9642520B2 (en) | 2009-04-01 | 2017-05-09 | Tearscience, Inc. | Background reduction apparatuses and methods of ocular surface interferometry (OSI) employing polarization for imaging, processing, and/or displaying an ocular tear film |
| US10004396B2 (en) | 2009-04-01 | 2018-06-26 | Tearscience, Inc. | Ocular surface interferometry (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film |
| JP2015091322A (en) * | 2009-04-01 | 2015-05-14 | テイアサイエンス・インコーポレーテツド | Ocular surface interference spectroscopy (osi) device, system, and method for performing image formation, processing, and/or display of ocular tear film, and/or measuring thickness of ocular tear film layer |
| US11771317B2 (en) | 2009-04-01 | 2023-10-03 | Tearscience, Inc. | Ocular surface interferometry (OSI) for imaging, processing, and/or displaying an ocular tear film |
| US8545017B2 (en) | 2009-04-01 | 2013-10-01 | Tearscience, Inc. | Ocular surface interferometry (OSI) methods for imaging, processing, and/or displaying an ocular tear film |
| US9662008B2 (en) | 2009-04-01 | 2017-05-30 | Tearscience, Inc. | Ocular surface interferometry (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film |
| US11259700B2 (en) | 2009-04-01 | 2022-03-01 | Tearscience Inc | Ocular surface interferometry (OSI) for imaging, processing, and/or displaying an ocular tear film |
| US9693682B2 (en) | 2009-04-01 | 2017-07-04 | Tearscience, Inc. | Ocular surface interferometry (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film |
| US10716465B2 (en) | 2009-04-01 | 2020-07-21 | Johnson & Johnson Vision Care, Inc. | Methods and apparatuses for determining contact lens intolerance in contact lens wearer patients based on dry eye tear film characteristic analysis and dry eye symptoms |
| US9888839B2 (en) | 2009-04-01 | 2018-02-13 | Tearscience, Inc. | Methods and apparatuses for determining contact lens intolerance in contact lens wearer patients based on dry eye tear film characteristic analysis and dry eye symptoms |
| US10582848B2 (en) | 2009-04-01 | 2020-03-10 | Tearscience, Inc. | Ocular surface interferometry (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film |
| US9999346B2 (en) | 2009-04-01 | 2018-06-19 | Tearscience, Inc. | Background reduction apparatuses and methods of ocular surface interferometry (OSI) employing polarization for imaging, processing, and/or displaying an ocular tear film |
| JP2013056152A (en) * | 2011-08-30 | 2013-03-28 | Oculus Optikgeraete Gmbh | Ophthalmic analytical instrument and method |
| US10582849B2 (en) | 2012-12-21 | 2020-03-10 | Tearscience, Inc. | Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography |
| US9668647B2 (en) | 2012-12-21 | 2017-06-06 | Tearscience Inc. | Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography |
| US9339177B2 (en) | 2012-12-21 | 2016-05-17 | Tearscience, Inc. | Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography |
| US10244939B2 (en) | 2012-12-21 | 2019-04-02 | Tearscience, Inc. | Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography |
| US9993151B2 (en) | 2012-12-21 | 2018-06-12 | Tearscience, Inc. | Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography |
| US11141065B2 (en) | 2013-05-03 | 2021-10-12 | Tearscience, Inc | Eyelid illumination systems and methods for imaging meibomian glands for meibomian gland analysis |
| US10278587B2 (en) | 2013-05-03 | 2019-05-07 | Tearscience, Inc. | Eyelid illumination systems and method for imaging meibomian glands for meibomian gland analysis |
| US11844586B2 (en) | 2013-05-03 | 2023-12-19 | Tearscience, Inc. | Eyelid illumination systems and methods for imaging meibomian glands for meibomian gland analysis |
| US10512396B2 (en) | 2013-11-15 | 2019-12-24 | Tearscience, Inc. | Ocular tear film peak detection and stabilization detection systems and methods for determining tear film layer characteristics |
| US9795290B2 (en) | 2013-11-15 | 2017-10-24 | Tearscience, Inc. | Ocular tear film peak detection and stabilization detection systems and methods for determining tear film layer characteristics |
| JP2017136212A (en) * | 2016-02-03 | 2017-08-10 | 株式会社ニデック | Ophthalmologic apparatus |
| JP2019202187A (en) * | 2017-03-14 | 2019-11-28 | 株式会社トプコン | Tear film thickness measurement apparatus and method |
| WO2020111104A1 (en) * | 2018-11-27 | 2020-06-04 | 株式会社トプコン | Ophthalmological device |
| JPWO2020111104A1 (en) * | 2018-11-27 | 2021-10-14 | 株式会社トプコン | Ophthalmic equipment |
| US11185220B2 (en) | 2019-04-24 | 2021-11-30 | Topcon Corporation | Ophthalmologic apparatus |
| US11503995B2 (en) | 2019-04-24 | 2022-11-22 | Topcon Corporation | Ophthalmologic apparatus |
| WO2020226082A1 (en) * | 2019-05-08 | 2020-11-12 | 株式会社トプコン | Ophthalmic device |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH07136120A (en) | Ophthalmologic apparatus | |
| JP5281846B2 (en) | Meibomian gland observation device | |
| CA2586139C (en) | Optical apparatus and method for comprehensive eye diagnosis | |
| JP4864516B2 (en) | Ophthalmic equipment | |
| JPS6223570B2 (en) | ||
| JPH0496730A (en) | Fine illumination image photographing device | |
| GB2478040A (en) | Image capture apparatus and method | |
| JPH0361447B2 (en) | ||
| US5719659A (en) | Ophthalmic apparatus having light polarizing means | |
| JPH0753151B2 (en) | Ophthalmic measuring device | |
| JPH04200436A (en) | Ophthamologic apparatus | |
| JP2000254099A (en) | Ophthalmologic device | |
| KR20070043836A (en) | Ophthalmologic instrument | |
| JP2022524881A (en) | Ophthalmic imaging methods, devices, and systems | |
| WO2000021432A1 (en) | Methods and apparatus for digital ocular imaging | |
| JPS60253429A (en) | Ophthalmic examination apparatus | |
| JP3501499B2 (en) | Optometrist | |
| JPS6117495B2 (en) | ||
| JP4160685B2 (en) | Ophthalmic equipment | |
| JPS6117494B2 (en) | ||
| JP3332489B2 (en) | Optometry device | |
| JPH05192298A (en) | Phorometric device | |
| JPH0531076A (en) | Visual function inspecting device | |
| JPH0866364A (en) | Ophthalmic equipment | |
| JP2930527B2 (en) | Ophthalmic examination device |