JPH07116247A - Method for sterilizing and purifying blood circulating and dialyzate piping pipeline for artificial dialysis method and its device - Google Patents

Abstract

PURPOSE:To rapidly and surely wash and sterilize a blood circulating pipeline and a supply pipeline for a dialyzate after removal of a dialyzer by successively and automatically supplying alkaline water and acidic water from one ends of the pipelines, thereby sterilizing and purifying the inside of the pipelines and the inside of dialysis apparatus attendant thereon. CONSTITUTION:The one ends of the blood removal side pipeline 2 and the blood return side pipeline 3 are coupled by a coupler 1 and the other end of the blood removal side pipeline 2 and the one end of the discharge side pipeline 5 of the dialyzate are coupled by a coupler 11 to form one piece of the pipeline. A device 12 for forming the alkaline water and acidic water by electrolysis of common salt water is internally provided with two tanks. The alkaline water is first injected from the one end of the pipeline, is passed therein and is then discharged from the other end. The acidic water is thereafter injected into the pipeline and the other end of the pipeline is closed to fill the pipeline with the acidic water. RO water or pure water is thereafter passed in the pipeline to be ready for a dialysis treatment of the next time.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for sterilizing and purifying blood circulation pipelines and dialysate piping pipelines used in artificial dialysis and an apparatus therefor.

[0002]

2. Description of the Related Art When renal function is deteriorated due to acute or chronic renal failure and the amount of urea or creatinine in the blood is increased, blood is purified by an artificial dialysis method or the like.

The principle of the artificial dialysis method is that blood is passed through a semipermeable membrane.
A dialysate composed of a bicarbon solution containing Na, Ca, Mg, Cl, lactate, glucose, etc. is contacted, the poison in the blood is discharged to the dialysate side, and the active ingredient in the dialysate is supplied to the blood side. To do.

Specifically, as shown in FIG. 3, a dialyzer 1 for bringing dialysate and blood into contact with each other through a semipermeable membrane, a blood removal side pipeline 2 constituting a blood circulation pipeline, and a blood return side pipe. A line 3, a supply-side pipeline 4 and a discharge-side pipeline 5, which constitute a dialysate piping pipeline, and a dialysate supply device 6.

A motor pump 7 and a supply device 8 for the blood anticoagulant (heparin) guided to the outside of the body are interposed in the blood removal pipeline 2, a needle at the tip of the device is pierced into a vein, and the base end thereof is dialyzed. 1 is connected to the blood supply port, and the blood return side pipeline 3 is provided with an air chamber 9 for bleeding air, the needle at the tip thereof is pierced into the artery, and the base end portion thereof is used as the blood outlet of the dialyzer 1. On the other hand, a motor pump 7 is interposed in the dialysate supply side pipeline 4, the tip of the motor pump 7 is connected to the dialysate supply port of the dialyzer 1, and a negative pressure gauge 10 is connected to the dialysate discharge side pipeline 5. It is interposed and its proximal end is connected to the dialysate outlet of the dialyzer 1.

Blood collected from the vein is supplied to the dialyzer 1 through the blood removal side pipeline 2, while the dialysate from the dialysate supply device 6 is supplied to the supply side pipeline 4.
Supply to dialyzer 1 through
Inside, the blood and the dialysate are brought into contact with each other through the semipermeable membrane as described above, and the poison in the blood is discharged into the dialysate, and then the blood is returned to the body through the blood return side pipeline 3, and the dialysate is Discharge through the discharge pipeline 5.

[0007] Artificial dialysis is performed at a dialysate flow rate of 500 ml / min for a blood flow rate of 100-200 ml / min and a dialysis time of about 4 to 5 hours. After dialysis, the disposable dialyzer 1 is removed and A blood removal side pipeline 2, a blood return side pipeline 3, a dialysate supply side pipeline 4 and a discharge side pipeline 5, and a motor pump 7 attached thereto The heparin supply device 8, the air chamber 9, and the negative pressure gauge 10 are reused.

[0008] However, sodium components and the like adhere to the inner walls of these pipelines during dialysis, and the secondary infection of Staphylococcus aureus and the like propagates with this as a medium, and these bacteria are resistant to chemical sterilization. On the contrary, it has been reported that the drug itself propagates as a medium.

Therefore, conventionally, the dialysis equipment such as the pipeline and the accompanying motor pump 7, heparin supply device 8, air chamber 9, negative pressure gauge 10 and the like are subjected to hot water disinfection or chemical disinfection once a day. Especially chemical disinfection is performed in most hospitals.

[0010]

However, in this case, chemical disinfection uses a high concentration of hypochlorous acid or formalin, which requires a long time for the preparation and sterilization using a high concentration solution. From the point of washing, it is necessary to always have an observer during sterilization and washing in order to avoid danger, which is one of the causes of large burden of labor cost in hospitals and the like.

Further, since a high concentration of hypochlorous acid or formalin is used, leakage from the pipeline or secondary pollution due to the waste liquid thereof may cause a serious problem.

[0012]

[Means for Solving the Problems] In order to solve the above problems, in the present invention, after the artificial dialysis is completed and the blood circulation pipeline and the dialysate piping are removed from the dialyzer, the respective pipelines are connected. One pipeline is connected to one another, and alkaline water and acidic water produced by electrolysis of saline solution are automatically and sequentially supplied from one end of the pipeline to sterilize and purify the interior of the pipeline and its associated dialysis equipment. It proposes a method.

Further, according to the present invention, a connecting means for connecting the blood circulation pipeline and the dialysate piping pipeline removed from the dialyzer to one pipeline, and a device for producing alkaline water and acidic water by electrolysis of saline solution. And a sterilizing and purifying device for blood circulation and dialysate piping pipeline in an artificial dialysis method, which comprises means for sequentially supplying the alkaline water and the acidic water to the pipeline.

[0014]

[Effect] That is, for example, when 5% saline is electrolyzed with the cathode and anode separated by a diaphragm, alkaline water of pH 11.8 ± 0.3 containing hydroxide ions, chlorine ions, etc. is obtained on the cathode side. PH 2.2 ± including hydrogen ions and sodium ions on the side
0.3, ORP (oxidation-reduction potential) 2000 mV or more acidic water is obtained.

Of these, alkaline water has the ability to wash and dissolve oils and fats, soluble proteins, acidic crystals, etc., and most microorganisms such as bacteria and viruses have a pH of 2.7 or less and an ORP of about +1.
It cannot survive above 000 mV, and therefore acidic water has a bactericidal action against microorganisms.

Therefore, after the artificial dialysis is completed and the blood circulation pipeline and the dialysate supply pipeline are removed from the dialyzer, these pipelines are connected by an appropriate coupler to form one pipeline, and this end portion is connected. If more alkaline water is injected, and then acidic water is injected, the alkaline water and the acidic water permeate through the pipeline to the inside of the motor pump, the heparin supply device, the air chamber, and the negative pressure gauge. The inner wall of the pipeline,
And the fats and oils, soluble proteins, and acidic crystalline substances adhering to the inside of the dialysis equipment accompanying this are dissolved and removed, and depending on the acidic water, sterilization of bacteria that survive inside the pipeline and the dialysis equipment accompanying this Processing is performed.

Acidic water has the property of depriving the target object of electrons and oxidizing, neutralizing itself, and having no persistence, and returning to ordinary water when exposed to light or air. Thus, even if the acidic water is made to flow in the pipeline after the alkaline water, the water returns to normal water and does not remain.

After the interior of the pipeline and its associated dialysis equipment are washed and sterilized with alkaline water and acidic water, RO water or pure water that has passed through the ultrafiltration membrane is placed in the pipeline. Wash by flushing and prepare for the next artificial dialysis.

[0019]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will now be described in detail with reference to the illustrated embodiments. FIG. 1 shows a pipeline and its accessories for cleaning and sterilizing a pipeline in an automatic supply device for an individual dialysate as shown in FIG. An example is shown. Blood removal side pipeline 2 from which dialyzer 1 is removed, blood return side pipeline 3, dialysate supply side pipeline 4 and discharge side pipeline 5 are blood removal side pipeline 2 and blood return side Connect one end of the side pipeline 3 with a coupler 11 which is a one-touch joint,
The other end of the blood return side pipeline 3 and one end of the dialysate supply side pipeline 4 are connected by a coupler 11, and the other end of the blood removal side pipeline 2 and one end of the dialysate discharge side pipeline 5 are connected by a coupler 11. Combined with to make one pipeline.

On the other hand, reference numeral 12 denotes a device for producing alkaline water and acidic water by electrolysis of 5% saline solution. Two tanks are provided in the device, and the produced alkaline water and acidic water are Each is stored individually in these tanks.

Alkaline water is first injected from one end of the pipeline formed by coupling with the coupler 11 into one pipeline, and then allowed to pass through, and then discharged from the other end.

After that, the acidic water stored in the acidic tank is injected into the pipeline while controlling the flow rate according to the number of dialysis machines, and the other end of the pipeline is closed to supply the acidic water.
Fill the pipeline for about 30 minutes.

After washing and sterilizing treatment with alkaline water and acidic water, RO water or pure water is flown into the pipeline to prepare for the next dialysis treatment.

FIG. 2 shows an example of the washing and sterilizing process of the pipeline and its accessories in the automatic supply apparatus for the dialysate for a large number of people, which is described as attached to the blood removal side pipeline 2 in FIG. The heparin supply device 8, the motor pump 7 attached to the dialysate supply side pipeline 4 and the negative pressure gauge 10 attached to the dialysate discharge side pipeline 5 are shown here. The apparatus 12 for producing alkaline water and acidic water by electrolysis of saline solution, which is omitted and is omitted in FIG. 1, is described in detail.

According to FIG. 2, the apparatus 12 for producing alkaline water and acidic water comprises a salt tank 13, an electrolyzer 14, an acidic water tank 15, an alkaline water tank 16 and the like.
Salt is replenished from the salt tank 13 so that the concentration of the salt solution inside is about 5%, and the acidic water generated by electrolysis is stored in the acidic tank 15 and the alkaline water is stored in the alkaline water tank 16. .

Also in this case, the alkaline water is supplied from the alkaline water tank 16 and then the acidic water from the acidic water tank 15 to the supply pipeline of each dialysate, which is made into one pipeline by the coupler 11. The alkaline water and the acidic water discharged from each dialysate supply pipeline are discharged from a discharge port having a solenoid valve 17.

[0026]

In summary, according to the present invention, the blood circulation pipeline and the dialysate supply pipeline after the dialyzer is removed can be cleaned and sterilized in a short time, reliably and without residue. it can.

[Brief description of drawings]

FIG. 1 is a schematic diagram showing a cleaning / sterilization treatment system showing an embodiment of the present invention.

FIG. 2 is a schematic diagram showing a cleaning / sterilization treatment system showing another embodiment of the present invention.

FIG. 3 is a diagram showing an outline of an artificial dialysis method.

[Explanation of Codes] 1 dialyzer 2 blood removal side pipeline 3 blood return side pipeline 4 dialysate supply side pipeline 5 dialysate discharge side pipeline 6 dialysate supply device 7 motor pump 8 is a heparin supply device 9 is an air chamber 10 is a negative pressure gauge 11 is a coupler 12 is a device for generating alkaline water and acidic water by electrolysis of saline solution 13 is a salt tank 14 is an electrolyzer 15 is an acidic water tank 16 is an alkali Water tank 17 is a solenoid valve

Claims (2)

[Claims] 1. After the artificial dialysis is completed, the blood circulation pipeline and the dialysate piping pipeline are removed from the dialyzer, and the pipelines are connected to form one pipeline, and saline is fed from one end of the pipeline. Blood circulation in an artificial dialysis method characterized by sequentially supplying alkaline water and acidic water generated by electrolysis of water to sterilize and purify the inside of a pipeline and its associated dialysis equipment, and a dialysate piping pipeline. Sterilization purification method. 2. A connecting means for connecting the blood circulation pipeline and the dialysate piping pipeline, which are removed from the dialyzer, to one pipeline, and a device for generating alkaline water and acidic water by electrolysis of saline. A sterilizing and purifying device for blood circulation and dialysate pipe pipelines in an artificial dialysis method, characterized by comprising means for sequentially supplying alkaline water and acidic water to the pipeline.