JPH0692437B2 - 結晶化装置 - Google Patents
結晶化装置Info
- Publication number
- JPH0692437B2 JPH0692437B2 JP63199047A JP19904788A JPH0692437B2 JP H0692437 B2 JPH0692437 B2 JP H0692437B2 JP 63199047 A JP63199047 A JP 63199047A JP 19904788 A JP19904788 A JP 19904788A JP H0692437 B2 JPH0692437 B2 JP H0692437B2
- Authority
- JP
- Japan
- Prior art keywords
- hose
- clamping
- crystallization
- tightening
- elastic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002425 crystallisation Methods 0.000 claims description 47
- 230000008025 crystallization Effects 0.000 claims description 44
- 230000006835 compression Effects 0.000 claims description 11
- 238000007906 compression Methods 0.000 claims description 11
- 108090000623 proteins and genes Proteins 0.000 claims description 10
- 102000004169 proteins and genes Human genes 0.000 claims description 10
- 230000003014 reinforcing effect Effects 0.000 claims description 4
- 229920002379 silicone rubber Polymers 0.000 claims description 3
- 239000013013 elastic material Substances 0.000 claims description 2
- 239000004945 silicone rubber Substances 0.000 claims description 2
- 239000011796 hollow space material Substances 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 33
- 238000002474 experimental method Methods 0.000 description 9
- 239000013078 crystal Substances 0.000 description 8
- 239000007788 liquid Substances 0.000 description 7
- 238000005185 salting out Methods 0.000 description 7
- 238000010586 diagram Methods 0.000 description 6
- 239000011521 glass Substances 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 239000012266 salt solution Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000005526 G1 to G0 transition Effects 0.000 description 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 3
- 239000007853 buffer solution Substances 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 239000012460 protein solution Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 229910052710 silicon Inorganic materials 0.000 description 3
- 239000010703 silicon Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000011038 discontinuous diafiltration by volume reduction Methods 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000005357 flat glass Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000005661 hydrophobic surface Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000007562 laser obscuration time method Methods 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000011277 treatment modality Methods 0.000 description 1
- 238000001947 vapour-phase growth Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
- C30B7/14—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions the crystallising materials being formed by chemical reactions in the solution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/06—Crystallising dishes
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
- C30B29/54—Organic compounds
- C30B29/58—Macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B35/00—Apparatus not otherwise provided for, specially adapted for the growth, production or after-treatment of single crystals or of a homogeneous polycrystalline material with defined structure
- C30B35/002—Crucibles or containers
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S117/00—Single-crystal, oriented-crystal, and epitaxy growth processes; non-coating apparatus therefor
- Y10S117/901—Levitation, reduced gravity, microgravity, space
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T117/00—Single-crystal, oriented-crystal, and epitaxy growth processes; non-coating apparatus therefor
- Y10T117/10—Apparatus
- Y10T117/1024—Apparatus for crystallization from liquid or supercritical state
- Y10T117/1092—Shape defined by a solid member other than seed or product [e.g., Bridgman-Stockbarger]
Landscapes
- Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3726765.5 | 1987-08-12 | ||
| DE3726765 | 1987-08-12 | ||
| DE3738840.1 | 1987-11-16 | ||
| DE19873738840 DE3738840A1 (de) | 1987-08-12 | 1987-11-16 | Kristallisationseinrichtung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01139102A JPH01139102A (ja) | 1989-05-31 |
| JPH0692437B2 true JPH0692437B2 (ja) | 1994-11-16 |
Family
ID=25858532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63199047A Expired - Lifetime JPH0692437B2 (ja) | 1987-08-12 | 1988-08-11 | 結晶化装置 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5009861A (enExample) |
| EP (1) | EP0303224A3 (enExample) |
| JP (1) | JPH0692437B2 (enExample) |
| CA (1) | CA1322449C (enExample) |
| DE (1) | DE3738840A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5139605A (en) * | 1986-05-07 | 1992-08-18 | Messerschmitt-Bolkow-Blohm Gmbh | Method and apparatus for crystallizing substances dissolved in a liquid at zero-gravity |
| US6027565A (en) * | 1991-02-25 | 2000-02-22 | Bugg; Charles E. | Method and apparatus for crystalizing macromolecules in microgravity |
| DE69202701T2 (de) * | 1991-02-25 | 1995-09-28 | Schering Corp | KRISTALLISIEREN VON BIOLOGISCHEN MAKROMOLEKüLEN UNTER SCHWERELOSIGKEIT. |
| US5427335A (en) * | 1992-07-13 | 1995-06-27 | The University Of Tennessee Research Corporation | Method for producing extreme microgravity in extended volumes |
| US5256241A (en) * | 1992-08-28 | 1993-10-26 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Method for controlling protein crystallization |
| JP2812629B2 (ja) * | 1992-11-25 | 1998-10-22 | 宇宙開発事業団 | 結晶成長セル |
| JP3094880B2 (ja) * | 1995-03-01 | 2000-10-03 | 住友金属工業株式会社 | 有機化合物の結晶化制御方法およびそれに用いる結晶化制御用固体素子 |
| US7214540B2 (en) * | 1999-04-06 | 2007-05-08 | Uab Research Foundation | Method for screening crystallization conditions in solution crystal growth |
| US7250305B2 (en) * | 2001-07-30 | 2007-07-31 | Uab Research Foundation | Use of dye to distinguish salt and protein crystals under microcrystallization conditions |
| US7247490B2 (en) * | 1999-04-06 | 2007-07-24 | Uab Research Foundation | Method for screening crystallization conditions in solution crystal growth |
| US20030022383A1 (en) * | 1999-04-06 | 2003-01-30 | Uab Research Foundation | Method for screening crystallization conditions in solution crystal growth |
| US7244396B2 (en) * | 1999-04-06 | 2007-07-17 | Uab Research Foundation | Method for preparation of microarrays for screening of crystal growth conditions |
| DE60034033T2 (de) * | 1999-04-06 | 2007-12-06 | University of Alabama, Birmingham Research Foundation, Birmingham | Vorrichtung zum screening von kristallisierungsbedingungen in lösungen zur kristallzüchtung |
| US6630006B2 (en) * | 1999-06-18 | 2003-10-07 | The Regents Of The University Of California | Method for screening microcrystallizations for crystal formation |
| US6750064B2 (en) * | 2000-12-28 | 2004-06-15 | S.S.C.I. Inc. | Methods of screening for possible solid forms |
| US7670429B2 (en) | 2001-04-05 | 2010-03-02 | The California Institute Of Technology | High throughput screening of crystallization of materials |
| DE10144526A1 (de) * | 2001-09-10 | 2003-04-03 | Lpkf Laser & Electronics Ag | Verfahren und Vorrichtung zur Bestimmung der mittleren Leistung eines Lasers |
| US20070026528A1 (en) * | 2002-05-30 | 2007-02-01 | Delucas Lawrence J | Method for screening crystallization conditions in solution crystal growth |
| US20040007672A1 (en) * | 2002-07-10 | 2004-01-15 | Delucas Lawrence J. | Method for distinguishing between biomolecule and non-biomolecule crystals |
| US7198759B2 (en) * | 2002-07-26 | 2007-04-03 | Applera Corporation | Microfluidic devices, methods, and systems |
| WO2004106598A1 (ja) * | 2003-05-27 | 2004-12-09 | Japan Aerospace Exploration Agency | 生体高分子結晶生成装置及び方法 |
| US20090010388A1 (en) * | 2007-06-06 | 2009-01-08 | Stahly Barbara C | Microplate and methods of using the same |
| US8018588B2 (en) * | 2007-06-06 | 2011-09-13 | Aptuit, Inc. | Sample holder and sample preparation device |
| WO2020170321A1 (ja) * | 2019-02-19 | 2020-08-27 | 株式会社コンフォーカルサイエンス | 生体高分子結晶化装置 |
| WO2024206123A1 (en) * | 2023-03-24 | 2024-10-03 | Krizan Jason | Securing crystal feedstock for deployment in zero gravity crystal growth furnaces to manufacturing satellites |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2603667A (en) * | 1950-01-26 | 1952-07-15 | Phillips Petroleum Co | Fractional crystallization |
| NL97193C (enExample) * | 1953-12-08 | |||
| US3036894A (en) * | 1958-10-22 | 1962-05-29 | Jasper A Forestiere | Method of using testing containers |
| US4263010A (en) * | 1979-10-31 | 1981-04-21 | University Patents, Inc. | Control method and apparatus for crystallizer process control |
| JPS62106000A (ja) * | 1985-10-30 | 1987-05-16 | Fujitsu Ltd | 生体高分子結晶自動作製装置 |
-
1987
- 1987-11-16 DE DE19873738840 patent/DE3738840A1/de active Granted
-
1988
- 1988-08-09 US US07/229,950 patent/US5009861A/en not_active Expired - Fee Related
- 1988-08-09 EP EP88112911A patent/EP0303224A3/de not_active Withdrawn
- 1988-08-11 JP JP63199047A patent/JPH0692437B2/ja not_active Expired - Lifetime
- 1988-08-12 CA CA000574699A patent/CA1322449C/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| ＪｏｕｒｎａｌｏｆＣｒｙｓｔａｌＧｒｏｗｔｈ４２（１）（１９７７）Ｐ．２５３−２５８ |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0303224A2 (de) | 1989-02-15 |
| EP0303224A3 (de) | 1989-04-19 |
| CA1322449C (en) | 1993-09-28 |
| DE3738840C2 (enExample) | 1991-04-11 |
| JPH01139102A (ja) | 1989-05-31 |
| DE3738840A1 (de) | 1989-02-23 |
| US5009861A (en) | 1991-04-23 |
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