JPH0663386A - Emulsion composition - Google Patents

Abstract

PURPOSE:To provide an emulsion compsn. improved inpreservation stability of docosahexaenoic acid or its salt or ester and capable of effectively applying to cosmetic, medicine, etc. CONSTITUTION:The emulsion compsn. consists of a surfactant, a water soluble polyhydric alcohol having >=2 hydroxide groups in the molecule and an oil component in which docosahexaenoic acid or its salt or ester is contained, and the oil in water type emulsion compsn. further contains water.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention provides an emulsified composition having improved storage stability of docosahexaenoic acid or a salt or ester thereof, which can be effectively used in cosmetics, pharmaceuticals and the like.

[0002]

2. Description of the Related Art Generally, docosahexaenoic acid or its salt or ester has a drawback that when it is mixed with cosmetics, pharmaceuticals, etc., it has poor oxidative stability and is liable to become lipid peroxides, impairing the stability of the product. ing. In recent years, a lot of researches on emulsification have been made, many emulsifiers have been developed, and the progress of emulsification technology has been remarkable, and very stable emulsions have been widely used in all industries. However, the conventional method has a problem that it is not possible to sufficiently prevent the peroxidation and coloration of docosahexaenoic acid or a salt or ester thereof, and it is not always possible to obtain a satisfactory emulsion composition.

[0003]

Means for Solving the Problems The inventors of the present invention have conducted extensive studies to develop a stable emulsion having uniform and fine particles using a surfactant as an emulsifier, and as a result, a water-soluble polyvalent By emulsifying the oil phase component in an alcohol and a surfactant, it was found that an emulsion composition having a fine particle size and good stability can be obtained, and docosahexaenoic acid or a salt or ester thereof in the oil phase component. It has been found that the inclusion of docosahexaenoic acid improves the storage stability of the derivative and a highly safe emulsion composition. Furthermore, they have found that a stable oil-in-water emulsion composition in which uniform fine particles are dispersed can be obtained by mixing this emulsion composition with water, and completed the present invention.

That is, the present invention comprises a surfactant, a water-soluble polyhydric alcohol having two or more hydroxyl groups in the molecule,
An emulsified composition containing an oil phase component and containing docosahexaenoic acid or a salt or ester thereof in the oil phase component, and an oil-in-water emulsion obtained by mixing the emulsified composition and water. A composition is provided.

The emulsified composition obtained by the present invention is a transparent or translucent viscous liquid or gel, and the oil-in-water emulsified composition to which water is added is an emulsion of milky white fine particles. These fine particle emulsions have a fine particle diameter that cannot be reached by the conventional emulsification method of emulsifying and mixing the oil phase component after dissolving the surfactant in water. It is considered that the cause of this fine particle formation is that the surfactant promptly aligns and interacts with the polyhydric alcohol-oil phase component interface having a lower interfacial tension than the water-oil phase component interface.

The water-soluble polyhydric alcohol used in the present invention is a water-soluble polyhydric alcohol having two or more hydroxyl groups in the molecule, such as ethylene glycol, propylene glycol, 1,4-butylene glycol and dipropylene glycol. , Glycerin, and diglycerin, triglycerin, polyglycerin such as tetraglycerin, glucose, maltose, maltitol, sucrose, fructose, xylitol, sorbitol, maltotriose, threitol, erythritol, starch-degrading sugar,
For example, starch-decomposing sugar reducing alcohol. Of these,
One kind or two or more kinds are selected and used. The compounding amount is preferably 2 to 95% by weight (hereinafter, simply referred to as "%") of the emulsified composition.

The surfactant used in the present invention is
As the lipophilic nonionic surfactant, for example, sorbitan monooleate, sorbitan monoisostearate,
Sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate and other sorbitan fatty acid esters, mono cottonseed oil fatty acid glycerin, monoerucic acid glycerin, sesquioleate glycerin, monostearate glycerin,
α, α'-glycerin pyroglutamate oleate, glycerin or polyglycerin fatty acid esters such as glycerin monostearate malic acid, propylene glycol fatty acid esters such as propylene glycol monostearate, hydrogenated castor oil derivative, glycerin alkyl ether, etc. Can be mentioned.

Examples of the hydrophilic nonionic surfactant include POE such as POE sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate and the like.
POE-sorbit monolaurate, POE-sorbit monooleate, POE-sorbit pentaoleate, and other POE sorbit fatty acid esters, POE-glycerin monostearate, POE-glycerin monoisostearate, POE- POE glycerin fatty acid esters such as glycerin triisostearate, POE-monooleate, POE-distearate, POE-monodioleate, POE fatty acid esters such as ethylene glycol distearate, POE-lauryl ether, POE-oleyl ether, POE-stearyl ether , POE-behenyl ether, POE2-octyldodecyl ether, POE-cholestanol ether and other POE alkyl ethers, POE-octylphenyl ether, POE-nonylphenyl ether, PO
POE alkyl phenyl ethers such as E-dinonyl phenyl ether, POE ・ POP cetyl ether, POE ・ POP2-
Decyl tetradecyl ether, POE ・ POP monobutyl ether, POE ・ POP hydrogenated lanolin, POE ・ POP alkyl ethers such as POE ・ POP glycerin ether, tetraPOE ・ tetraPOP ethylenediamine condensates such as Tetronic, POE castor oil, POE hydrogenated castor oil, POE hydrogenated castor oil monoisostearate, POE hydrogenated castor oil triisostearate and other castor oil or hydrogenated castor oil derivatives, POE sorbitol beeswax and other POE beeswax lanolin derivatives, coconut oil fatty acid diethanolamide, laurin Examples thereof include alkanolamides such as acid monoethanolamide.

Examples of the anionic surfactant include a base for soap, a fatty acid soap such as sodium laurate and sodium palmitate, a higher alkyl sulfate ester salt such as sodium lauryl sulfate and potassium lauryl sulfate, POE lauryl sulfate triethanolamine, and the like. POE Alkyl ether sulfate such as sodium lauryl sulfate, N-acyl sarcosinic acid, higher fatty acid amide sulfonate, phosphate ester salt, alkylbenzene sulfonate, N-acyl glutamate, higher fatty acid ester sulfate, sulfated Oil etc. are mentioned.

Examples of the cationic surfactant include alkyl trimethyl ammonium salts such as stearyl trimethyl ammonium chloride and lauryl trimethyl ammonium chloride, distearyl dimethyl ammonium dialkyl dimethyl ammonium salts, alkyl pyridinium salts such as cetyl pyridinium chloride and alkyl quaternary salts. Examples thereof include ammonium salts, alkyldimethylbenzylammonium salts, and acylisoquinolinium salts.

Examples of the amphoteric surfactant include 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-
Imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyline amphoteric surfactants such as carboxyethyloxy disodium salt, 2-heptadecyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, Examples thereof include betaine-based surfactants such as lauryl dimethylamino acetic acid betaine, alkyl betaine, amidobetaine, and sulfobetaine.

The surfactant and the polyhydric alcohol having two or more hydroxyl groups in the molecule are used in a weight ratio of 1: 0.1-.
A range of 1,000 is preferred. If the amount of the surfactant is more than 10 relative to 1 of the polyhydric alcohol, it becomes difficult to dissolve the surfactant, and if it is less than 1/1000, the emulsion stability becomes poor.

The oil phase components used in the present invention include animal and vegetable oils and fats such as beef tallow, squalane, olive oil and rice bran oil and hydrocarbons, mineral oils such as liquid paraffin and vaseline, isopropyl myristate, vitamin A palmitate, and vitamin E acetate. Examples thereof include oils and oil-soluble agents commonly used in the fields of cosmetics, pharmaceuticals, foods, etc., such as ester oils such as, and silicone oils such as methylphenyl silicone and dimethyl silicone.

The total amount of the surfactant and polyhydric alcohol used relative to the oil phase component 1 is preferably 0.2 or more by weight. Docosahexaenoic acid used in the present invention can be used as a free fatty acid.

Further, as a salt of docosahexaenoic acid,
Metal salts such as sodium salt and potassium salt, amine salts such as triethanolamine salt, monoethanolamine salt and the like can be used. Furthermore, as the ester of docosahexaenoic acid, an ester with a monohydric alcohol such as methanol or ethanol can be used.

[0016] The amount of blending is appropriately in the oil phase component, preferably
0.001 to 100% by weight, more preferably 0.01
It is desirable to blend it in an amount of up to 50% by weight.

In the emulsion composition according to the present invention, in addition to the above essential components, a drug, an ultraviolet absorber, a preservative, an antioxidant, etc. may be mixed and added depending on the purpose of use.
Further, alcohol, fatty acid, other water-soluble polymer, etc. may be added for the purpose of homogenizing stabilization and adjusting viscosity.

A surfactant is dissolved in a polyhydric alcohol,
An emulsion composition is obtained by gradually adding the oil phase component while stirring. In this case, it is preferable to carry out a homomixer treatment, but a good emulsified composition can be obtained even with a weak stirring force such as hand stirring.

The emulsion composition obtained here is a uniform, transparent or translucent gel or a viscous liquid, and as it is, for example, sun care jelly, beauty essence, edible jelly, medicinal jelly, massage jelly. As a lubricating oil, etc., it can be suitably used in various fields such as foods, cosmetics, medicines and feeds.

Next, the above emulsion composition and water are mixed to obtain a stable oil-in-water emulsion composition having fine and uniform emulsion particles. In this case, it is preferable to carry out a homomixer treatment.

Regarding the quantitative relationship between the emulsified composition and water, it is possible to form an emulsion in a very wide range of proportions, but generally 5 to 80 parts of the emulsified composition and 95
~ 20 copies.

In the above-mentioned water, if necessary, a lubricant, a water-soluble vitamin, a water-soluble preservative, a water-soluble drug, a water-soluble polymer and the like, an aqueous phase component generally used in the cosmetics, pharmaceuticals, foods and other industries. Can be dissolved.

The oil-in-water emulsion composition obtained here is a milky white viscous or low-viscosity liquid in which uniform fine particles are dispersed. Therefore, in this form as it is, homogeneous stabilization, viscosity adjustment or To add medicinal properties, other water-soluble polymers, drugs, surfactants, etc. can also be added to produce cosmetics such as emulsions, creams, foundations, toiletries such as shampoos and conditioners, urea creams, acne. It can be suitably used in various fields such as pharmaceuticals such as cream and foods such as mayonnaise.

[0024]

EXAMPLES The present invention will be described in more detail with reference to Examples and Comparative Examples, but the present invention is not limited thereto. The components were blended as shown in Example 1 in Table 1 and treated with a homomixer at 70 ° C. to prepare an emulsion composition.
Furthermore, 10 times the amount of water was added to this emulsion composition at room temperature with stirring to prepare an oil-in-water emulsion composition. The stability of the product was investigated between this oil-in-water emulsion composition and a comparative example prepared by a conventional emulsification method.

[0025]

[Table 1]

<Evaluation Criteria> Stability of Product over Time: Twenty women were divided into two groups to form a panel. The first group contains the oil-in-water emulsion composition of Example 1,
For the second group, a comparative example obtained by ordinary emulsification was used and applied to the skin. When docosahexaenoic acid is used as an external preparation for the skin, the docosahexaenoic acid deteriorates, resulting in a poor feeling in use. Therefore, the temporal stability of docosahexaenoic acid was evaluated by the difference in the feeling of use over time. Table 2 shows the evaluation results.

[0027]

[Table 2]

◯: Good usability Δ: Slightly poor usability ×: Poor usability

As is clear from these results, the emulsified composition of the present invention can contain docosahexaenoic acid in a stable manner, and does not deteriorate the usability with time. Furthermore, even after long-term storage, there was no coloring or odor with time.

[0030]

INDUSTRIAL APPLICABILITY The emulsion composition of the present invention has improved storage stability of docosahexaenoic acid or its salt or ester, and can be effectively used for cosmetics, pharmaceuticals and the like.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁵ Identification code Office reference number FI technical display location A61K 7/00 D 9164-4C J 9164-4C B01F 17/04

Claims (2)

[Claims] 1. A surfactant, a water-soluble polyhydric alcohol having two or more hydroxyl groups in the molecule, and an oil phase component, and docosahexaenoic acid or a salt or ester thereof in the oil phase component. An emulsified composition characterized by the above. 2. A surfactant, a water-soluble polyhydric alcohol having two or more hydroxyl groups in the molecule, and an oil phase component, and docosahexaenoic acid or a salt or ester thereof in the oil phase component. An oil-in-water emulsion composition, which comprises an emulsion composition and water.