JPH0654907A - Injection syringe - Google Patents

Abstract

PURPOSE:To inject and mix a medicine with a simple action in a short time without causing pollution by inserting a container into an outer tube, inserting the second needle tube into a gasket, moving a container main body in the axial direction against an injection syringe main body, sliding the gasket in the container main body, and discharging the liquid in the container via the first needle tube. CONSTITUTION:A container 10 is set to the decompressed state, the first needle tube 3 of an injection syringe 100 is pierced into the elastic plug 106 of an infusion bag 105, a film is peeled off, the container 10 is inserted into an outer tube 2, a connection section 6 is hooked in a space 161 after passing through the opening 162 of a gasket 12, and the second needle tube 5 is pierced into the thin section 14 of the gasket 12. When the rear end of the container 10 is pressed in the tip direction and the container main body 11 is inserted into an outer tube 2, the connection section 6 and a hook section 16 are hooked, thus only the container main body 11 is moved in the tip direction while only the gasket 12 is connected to the rear end of a tube body 4. The chemical in the container 10 is injected into the infusion bag 105 and blended with an infusion.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a syringe, and more particularly to a syringe used for compounding a liquid medicine.

[0002]

2. Description of the Related Art Prior to administering an infusion solution to a patient, the infusion solution filled in an infusion bag is optionally mixed with a drug such as vitamins, heparin, and antibiotics. There is.

In order to mix such drugs, first, the puncture needle of the syringe is inserted into the elastic stopper of the infusion bag, the plunger is pulled to collect the infusion solution in the infusion bag, and then the collected infusion solution is collected. Transfer to a container containing the drug to be blended (powdered), dissolve and mix the drug in the container, then again suck and sample the drug mixture with the syringe,
This is performed by inserting a puncture needle into the elastic stopper of the infusion bag and pushing the plunger to inject the drug mixture into the infusion bag.

However, the formulation of such a chemical solution is
It has the disadvantages that the operating procedure is complicated and that the time required for compounding is long. In particular, a rapid response is indispensable for an emergency patient, but it is disadvantageous when a drug solution to be administered to such a patient is mixed.

Further, most of the mixing operation of the above-mentioned chemicals, particularly the dissolution and mixing of the chemicals, is carried out in the state of being in contact with the atmosphere, so that there is a risk of bacterial contamination and contamination of foreign substances. Further, when a plurality of types of drugs are blended, the above-mentioned blending operation is repeated, so that the above-mentioned drawback becomes more remarkable.

[0006]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a syringe capable of injecting and blending a drug without contamination and in a short time by a simple operation.

[0007]

The above object is achieved by the present invention described in (1) below. Also, the following (2)-
It is preferably (12).

(1) An outer tube, a first needle tube installed at the tip of the outer tube, a tube body installed in the outer tube and having a tip side communicating with the inside of the first needle tube, and the tube. A syringe body composed of a second needle tube installed on the rear end side of the body and a connecting portion formed on the outer peripheral portion of the second needle tube, a bottomed cylindrical container body, and the container body And a gasket capable of sliding in a liquid-tight manner along the inner surface of the container, wherein the gasket has a thin-walled portion through which the second needle tube can be pierced and the coupling portion is locked. And at least one container in which a stopper is formed, the container is inserted into the outer cylinder from the gasket side, and the second needle tube is pierced into the thin portion of the gasket, With the connecting part and the locking part locked, the container body is axially relatively moved with respect to the syringe body. A syringe characterized in that at least the liquid in the container is discharged through the first needle tube by moving and sliding the gasket in the container body.

(2) The syringe according to (1), wherein a solid or liquid drug is contained in the container.

(3) The syringe according to (1) or (2), wherein the inside of the container is in a depressurized state.

(4) The syringe according to any one of the above (1) to (3), which has a regulation means for regulating the axial position of the gasket with respect to the container body.

(5) The syringe according to any one of the above (1) to (4), which has a film for sealing the opening of the container body.

(6) The syringe according to any one of the above (1) to (5), wherein the engaging portion is formed of a concave portion and the connecting portion is formed of a convex portion that fits into the concave portion.

(7) The syringe according to any one of the above (1) to (6), wherein the gasket can be reciprocated in the container body by the engagement of the engagement portion and the connection portion.

(8) The syringe according to any one of (1) to (7) above, which has an encapsulating member that encapsulates the second needle tube and that can be pierced by the second needle tube.

(9) The syringe according to any one of the above (1) to (8), which has a film for sealing an opening on the rear end side of the outer cylinder.

(10) The syringe according to any one of the above (1) to (9), which has a cap for encapsulating the first needle tube.

(11) The syringe according to any one of the above (1) to (10), wherein a holding member is attached to the bottom of the container body.

(12) The syringe according to any one of the above (1) to (11), which is used by exchanging a plurality of containers containing medicines having different components.

[0020]

DETAILED DESCRIPTION OF THE INVENTION The syringe of the present invention will be described below in detail with reference to the preferred embodiments shown in the accompanying drawings. The syringe 100 of the present invention includes a syringe body 1 and a container 10. Hereinafter, these configurations will be sequentially described.

FIG. 1 is a vertical cross-sectional view showing a structural example of a syringe body according to the present invention, and FIG. 2 is a view taken along the line II-II in FIG. For convenience of explanation, the upper side in FIG. 1 is referred to as the front end and the lower side is referred to as the rear end. As shown in FIG. 1, the syringe body 1 has a cylindrical outer cylinder 2 having a bottom portion 2a on the distal end side.
A first needle tube 3 protruding from the bottom portion 2a is installed at the tip of the.

The first needle tube 3 in the illustrated configuration example is, for example, an elastic plug 106 that seals the opening of the infusion bag 105.
A bottle needle that is pierced in (see FIGS. 7 and 8), and a plurality of side holes 31 that communicate with the inner cavity of the first needle tube 3 are formed in the side portion near the distal end portion. In the syringe of the present invention, the first needle tube is not limited to the bottle needle as shown in the drawing, but may be a normal metal puncture needle or the like.

Inside the outer cylinder 2, a tube body 4 whose tip side communicates with the inner cavity of the first needle tube 3 is installed substantially concentrically with the outer cylinder 2. In the illustrated example, the tube body 4 is integrally formed with the first needle tube 3, and is fixed to the bottom portion 2a of the outer cylinder 2 preferably by fusion bonding or adhesion.

On the rear end side of the tubular body 4, a second needle tube 5 having a sharp cutting edge 51 is installed with the cutting edge 51 facing the rear end. A container 10 described later is provided on the outer peripheral portion of the second needle tube 5.
The connecting portion 6 that engages with the engaging portion 16 formed on the gasket 12 is formed. As shown in FIG. 2, the connecting portion 6 is composed of a pair of fan-shaped (feather-shaped) small pieces that project in the radial direction of the second needle tube 5. In the illustrated example, the connecting portion 6 is formed integrally with the tubular body 4.

The constituent materials of the outer cylinder 2, the first needle tube 3, the tube body 4 and the connecting portion 6 are, for example, polyvinyl chloride, polyethylene, polypropylene, polystyrene, poly- (4-methylpentene-1). , Polycarbonate, acrylic resin, acrylonitrile-butadiene-
Styrene copolymer, polyester such as polyethylene terephthalate, butadiene-styrene copolymer, polyamide (for example, nylon 6, nylon 6.6, nylon 6
Examples include various resins such as 10 and nylon 12) or ceramics such as alumina. Among them, polypropylene, polyester, poly- (4-methylpentene-1) and the like are preferable because of easy molding. Resins are preferred. It is preferable that these materials are substantially transparent in order to secure the internal visibility.

The second needle tube 5 is preferably made of a metal such as stainless steel, titanium or aluminum or a hard resin. A wrapping member 7 that wraps at least the needle tip 51 of the second needle tube 5 is installed around the second needle tube 5. The encapsulating member 7 serves to prevent the needle tip 51 from being contaminated when it is not used and to prevent the liquid in the tubular body 4 from leaking from the needle tip 51.

As such an envelope member 7, for example,
A film made of various rubber materials such as natural rubber, isoprene rubber, butadiene rubber, silicone rubber, and latex rubber, which can be easily pierced by the needle tip 51, is preferably used.

A plate-shaped flange 2c is integrally formed with the outer cylinder 2 around the rear end opening 2b of the outer cylinder 2. When inserting the container 10 to be described later into the outer cylinder 2 or when pulling out from the outer cylinder 2, the syringe body 1 is fixed by applying a finger to the flange 2c.

In the syringe body 1 when not in use,
A film 8 for sealing the rear end opening 2b of the outer cylinder 2 preferably in an airtight manner is attached to the rear end surface of the flange 2c. As a result, the inside of the syringe body 1 is prevented from being contaminated and sterility is maintained. The film 8 is peeled off when the syringe body 1 is used. At this time, a tab 81 is formed at the edge of the film 8 so that the film 8 can be easily peeled off.

The film 8 is a single layer made of polyethylene, polypropylene, ionomer, polyester such as polyethylene terephthalate, polystyrene, resin such as poly- (4-methylpentene-1) or polyamide, or metal foil such as aluminum foil. Or a laminate obtained by laminating two or more layers of these. Since the laminated body of the metal foil and the resin layer has a low gas permeability, the use of such a film as the film 8 improves the airtightness in the outer cylinder 2 and effectively prevents the invasion of bacteria and the like. It is preferable because it is possible.

A cap 9 for enclosing the first needle tube 3 is attached to the distal end side of the outer cylinder 2. This cap 9
It has a function of preventing danger and preventing contamination of the first needle tube 3. In addition, in the syringe of the present invention, the film 8, 19
The cap 9 and the cap 9 may be provided if necessary, and these may not be present.

FIG. 3 is a vertical cross-sectional view showing a structural example of the container according to the present invention, FIG. 4 is a plan view of a gasket in the container shown in FIG. 3, and FIG. 5 is a cross-sectional view taken along line VV in FIG. Figure 6
FIG. 6 is a sectional view taken along line VI-VI in FIG. 4. For convenience of explanation, the upper side in FIGS. 3, 5 and 6 is referred to as the front end, and the lower side is referred to as the rear end.

As shown in FIG. 3, the container 10 is mainly composed of a bottomed cylindrical container body 11 having an open front end, and a gasket 12 capable of sliding in a liquid-tight manner along the inner surface of the container body 11. It is composed of.

The container body 11 is made of the same resin material or glass material as that of the outer cylinder 2 and the like, and is preferably substantially transparent in order to ensure the visibility of the inside. The outer diameter of the container body 11 is smaller than the inner diameter of the outer cylinder 2, and
The inner diameter of the container body 11 is larger than the outer diameter of the tube body 4 and the maximum diameter of the connecting portion 6. As a result, the container body 11 can be inserted to the inner part of the outer cylinder 2.

Further, the total length of the container body 11 is preferably substantially equal to or longer than the total length of the outer cylinder 2,
In particular, when the container body 11 is inserted to the innermost part of the outer cylinder 2 so that the chemical liquid in the container 10 can be discharged as much as possible regardless of the posture of the container 10, the rear end surface 122 of the gasket 12 is Inner surface 113 of the bottom of the container body 11
It is preferable that the contact is made with the above.

The inner surface of the container body 11 and the tip opening 1
Predetermined distance from 11 to the rear end side (for example, about 5 to 20 mm)
A ring-shaped protrusion 112 is formed along the inner circumference of the container body 11 at the separated positions. This protrusion 112 is
It is a restricting means for locking the gasket 12 on a rear end surface 122, which will be described later, and restricting the axial position of the gasket 12 with respect to the container body 11. That is, when the pressure inside the container 10 is reduced, the gasket 12 is prevented from moving to the rear end side of the container body 11 due to the pressure difference from the atmospheric pressure. The role of preventing the gasket 12 from moving toward the rear end side of the container body 11 when it is passed, or when moving the gasket 12 to the distal end side of the container body 11 or the container body 1
When it is removed from the container, it plays a role of preventing the gasket 12 from easily coming off from the container body 11.

In the unused container 10, the container body 1
A film 19 that seals the tip opening 111, preferably in an airtight manner, is attached to the tip of 1. Thereby, the inside of the locking portion 16 of the gasket 12 and the space 15 are prevented from being contaminated, and the sterility is maintained. Also, the container 1 when not in use
When the inside of 0 is kept in a reduced pressure state, by using the gas impermeable film 19, the airtightness of the tip opening 111 is obtained, which is advantageous for maintaining the reduced pressure state in the container 10. As the film 19, the same film as the film 8 can be used.

As shown in FIGS. 4, 5 and 6, the gasket 12 is made of various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber and silicone rubber (especially added rubber). (Sulfurized), various elastomers such as polyurethane, polyester, polyamide, olefin, and styrene, or a columnar member made of an elastic material such as a mixture thereof. The gasket 12 is not limited to the one made of the above-mentioned material as a whole, and may be made of at least the protrusion 18 and the thin portion 14 made of the above-mentioned material.

At the center of the gasket 12, there is formed a thin portion 14 through which the second needle tube 5 of the syringe body 1 can be inserted. The thickness of the thin portion 14 is, for example, 0.5 to 1.
It is about 0 mm.

A space 15 for accommodating and holding the encapsulating member 7 when the second needle tube 5 is pierced into the thin wall portion 14 is formed on the tip side of the thin wall portion 14, and this space 15 is further formed.
A locking portion 16 is formed on the tip side. The locking portion 16 is a recess in which the connecting portion 6 of the syringe body 1 is locked, and a pair of cross-sectional fan-shaped spaces 161 that communicate with the space 15 and a tip of the gasket 12 that communicates with the space 161. It is configured with an opening 162 through which the connecting portion 6 released to the surface 121 can pass.

In the space 161, the connecting portion 6 is rotatable by a predetermined angle (for example, about 50 to 130 °), and the contact surface 16 is substantially perpendicular to the tip surface 121 of the gasket 12.
3, 163 is abutted and its rotation is restricted. Connection part 6
In the state where the contact portion 163 contacts the contact surface 163, the connecting portion 6 is restricted from moving with respect to the locking portion 16 in both the front end direction and the rear end direction. The contour shape of the opening 162 is
It is almost equal to the connecting portion 6 (see FIG. 4).

A space 13 in which a needle tip 51 is located when the second needle tube 5 is pierced into the thin wall portion 14 is formed on the rear end side of the thin wall portion 14. Further, inside the gasket 12, one end communicates with the space 13 and the other end communicates with the gasket 12.
At least one vent hole 17 opening to the outer peripheral surface 123 of the
Are formed. The vent holes 17 are for discharging water vapor when the drug contained in the container 10 is freeze-dried. Therefore, this vent hole 17 is
It is provided as necessary depending on the form of the drug contained in the container.

On the outer peripheral surface 123 of the gasket 12, a plurality of ring-shaped protrusions 18 are formed over the entire circumference.
When the gasket 12 slides, the protrusion 18 adheres to the inner peripheral surface of the container body 11 to maintain airtightness and also has a function of maintaining appropriate slidability.

In such a container 10, the container body 11 also has a function as a plunger for moving the gasket 12 with respect to the container body 11, and the gasket 12 is a seal for sealing the container body 11. It has both a function as a stop member and a function for obtaining communication / blocking with the inside of the second needle tube 5. Therefore, the container 10 can be composed only of the container body 11 and the gasket 12 which are the minimum necessary members, and the number of parts is small as compared with the conventional container having a rubber stopper and a plunger rod exclusively for piercing a needle tube, The configuration is extremely simple and the operation is easy.

The inside of such a container 10 may be empty when not in use, but normally, it is preferable that a predetermined amount of the medicine is put in advance. The drug may be liquid or solid (including semi-solid). A typical example of the solid drug is a tablet or a powder (granule) drug 120 as shown in the figure, and in particular, it is a powder drug because it is easily dissolved or dispersed by a liquid introduced into the container 10. Those are preferable. Such powdery medicine 120 can be easily obtained by, for example, freeze-drying.

Further, when a solid drug is put in the container 10, the inside of the container 10 may be in a state substantially equal to the atmospheric pressure, but in a reduced pressure state (for example, 0.1 to 760).
mmHg) is preferred.

The medicine 1 enclosed in one container 10
20 is usually composed of a single active ingredient,
It may be a compounding agent containing two or more active ingredients. Drug 1
Specific examples of 20 include vitamin preparations (multivitamin preparations), various amino acids, antithrombotic agents such as heparin, insulin, antibiotics, antitumor agents, analgesics, cardiotonics, intravenous anesthetics, antiparkinson agents, and ulcers. Examples include therapeutic agents, adrenocortical hormone agents, arrhythmic agents, correction electrolytes and the like.

In the present invention, in order to prevent the solid drug, which cannot be completely dissolved or dispersed in the container 10, from being discharged from the side hole 31, the lumen of the tube body 4 or the second needle tube 5 and the like. A filter (not shown) may be provided in the flow path or in the rear end surface 122 of the gasket 12 or the like to prevent the passage of solid medicine. For this filter,
For example, a membrane filter, a mesh, a woven fabric, a non-woven fabric and the like can be mentioned.

At least the inside of the syringe body 1 and the container 10 are preferably subjected to a sterilization treatment such as high-pressure steam sterilization, gas sterilization or radiation sterilization in advance.

Next, an example of how to use the syringe 100 of the present invention will be described with reference to FIGS. 7 and 8.

A. Usage when the inside of the container 10 is depressurized in advance [1] First, as shown in FIG. 7, the cap 9 is removed and the first needle tube 3 of the syringe 100 is infused with the drug 120. The elastic stopper 106 that seals the opening of the bag 105 is inserted.

[2] Next, the films 8 and 19 are peeled off, and the container 10 is inserted into the outer cylinder 2 from the front end side through the rear end opening 2b of the outer cylinder 2 to connect the connecting portion 6 to the gasket 1.
The second needle tube 5 is passed through the second opening 162 and locked in the space 161, and the second needle tube 5 is attached to the thin portion 14 of the gasket 12.
The needle tip 51 is positioned in the space 13.

Here, since the inside of the container 10 has been depressurized in advance, the infusion bag 10 is affected by the pressure difference from the atmospheric pressure.
As shown by the arrow in FIG. 7, the infusion solution 107 in 5 passes through the side hole 31, the lumen of the first needle tube 3, the tube body 4 and the lumen of the second needle tube 5 in this order, and then in the container 10. Will be introduced to.

The needle tip 51 pierces the wrapping member 7 prior to the puncture of the thin portion 14, but the wrapping member 7 is
In the space 15 of the gasket 12, it is held in a compressed state in a bellows shape.

[3] Next, the container 10 is shaken or vibrated to dissolve or disperse the drug 120 in the infusion solution introduced into the container 10, and the drug solution 1 containing the active ingredient of the drug 120.
08. In addition, as the chemical liquid 108, the chemical 12
0 solution, suspension (emulsion) and the like.

[4] Next, as shown in FIG.
The rear end (bottom part) of 0 is pushed toward the front end, and the container body 11
Insert into the outer cylinder 2. Since the connecting portion 6 and the locking portion 16 are locked, only the container body 11 moves in the front end direction while the gasket 12 is connected to the rear end of the pipe body 4. As a result, the rear end of the gasket 12 and the container body 11
The volume of the portion surrounded by and decreases, and the liquid medicine 1 in the container 10
08 is injected into the infusion bag 105 through the lumen of the second needle tube 5, the tube body 4, the lumen of the first needle tube 3 and the side hole 31 in this order, as shown by the arrow in FIG. , Infusion solution.

[5] In the chemical liquid injection operation of the above [4], even if the container body 11 is inserted into the outer cylinder 2 until the rear end surface 122 of the gasket 12 contacts the bottom inner surface 113 of the container body 11, Since the drug solution 108 remains in the body 4 and the lumen of the first needle tube 3, it is not possible to inject the entire amount of the drug solution 108 into the infusion bag 105 by one pushing operation of the container 10. Therefore, when the container body 11 is inserted into the outer cylinder 2 to a certain depth, the container body 11 is pulled to the rear end side, and the infusion solution 107 in the infusion bag 105 is introduced into the container 10 through the same route as described above. Then, the remaining chemical liquid 108 is diluted and the container body 11 is pressed into the outer cylinder 2 again,
insert. By repeating such reciprocating movement of the container body 11 several times, the drug solution 108 can be supplied into the infusion bag 105 without waste, and an accurate amount of drug can be blended.

When pulling the container body 11 toward the rear end side, the container 10 is rotated counterclockwise in FIG. 4 by a predetermined angle with respect to the syringe body 1 so that the connecting portion 6 contacts the contact surface 163. Contact. As a result, the connecting portion 6 cannot pass through the opening 162, and only the container body 11 is pulled out while the gasket 12 is connected to the rear end of the pipe body 4, and the rear end of the gasket 12 and the container body 11 are separated. The volume of the portion surrounded by and increases, and the infusion solution 107 is introduced.

Further, when the gasket 12 slides, a predetermined resistance is applied when the protrusion 18 passes through the protrusion 112 of the container body 11, so that the gasket 12 is prevented from being accidentally pulled out from the container body 11. It

[6] When a drug having a different component is further mixed in the infusion bag 105, the first needle tube 3 is pierced by the elastic stopper 106 of the drug solution bag 105 and the container 1
0 is pulled out from the syringe body 1, a similar container 10 containing a drug to be newly mixed is set in the syringe body 1 in the same manner as in [2] above, and the same operations as in [3] to [5] below are performed. I do. As described above, when a plurality of types of drugs having different components are mixed, a plurality of containers 10 in which the respective drugs are stored may be prepared, and these may be appropriately exchanged and used, so that the operation is extremely simple. The time required for compounding is also short. Further, in the case of blending such a drug, the chance of contact with the outside air is extremely small, and there is no fear of bacterial contamination or foreign substance contamination.

The used container 10 has the gasket 1 in order to reduce the residual liquid amount in the container 10 as much as possible.
The rear end surface 122 of the container 2 is preferably withdrawn from the syringe main body 1 with the rear end surface 122 contacting or approaching the bottom inner surface 113 of the container main body 11.

Further, when the gasket 12 is pulled out from the second needle tube 5, the encapsulating member 7 which is compressed in a bellows shape.
Instantly restores the original shape and wraps the needle tip 51,
The liquid is prevented from leaking from the needle tip 51 and scattering around.

B. Method of use when the pressure in the container 10 is almost equal to atmospheric pressure First, the films 8 and 19 are peeled off, and the container 10 is inserted into the outer cylinder 2 from the front end side through the rear end opening 2b of the outer cylinder 2. Then, the connecting portion 6 is passed through the opening 162 of the gasket 12 and locked in the space 161, and the second needle tube 5 is pierced into the thin portion 14 of the gasket 12 to position the needle tip 51 in the space 13.

Next, the container body 11 is pressed toward the front end so that the container body 11 is inserted into the outer cylinder 2 to reduce the volume of the portion surrounded by the rear end of the gasket 12 and the container body 11. .

Next, the cap 9 is removed, and the first needle tube 3 is inserted into the elastic plug 106 of the infusion bag 105. Note that this operation may be performed before the insertion operation of the container body 11 into the outer cylinder 2.

Next, the container body 11 is pulled to the rear end side, and the infusion solution 107 in the infusion solution bag 105 is introduced into the container 10 through the same route as described above. Then, the same operations as those in [3] to [6] are performed.

C. Usage Method When Liquid Drug Is Preliminarily Stored in the Container 10 After performing the same operations as [1] and [2] above, the same operations as [4] to [6] above are performed.

In the syringe of the present invention, the container 10 has the above A to
Whatever form of C can be used by appropriately exchanging them for the syringe body 1. It should be noted that the above formulation (injection) of the drug is performed in the infusion bag 1
The method is not limited to that performed on 05, but may be performed on a bag that stores a liquid other than an infusion solution such as physiological saline or a dialysate, blood, plasma, or the like. Furthermore, it can also be used for administration of a medicinal solution to a living body such as intravenous injection, intraarterial injection and subcutaneous injection.

FIG. 9 is a partial vertical cross-sectional view showing another structural example of the syringe of the present invention. The syringe 101 shown in the same drawing is substantially the same as the syringe 100 except for the configurations of the connecting portion and the locking portion.

The connecting portion 6A of the syringe 101 is the second
The needle tube 5 is composed of a circular convex portion formed on the outer circumference of the end of the needle tube 5 on the tube body 4 side, and a male screw 61 is formed on the outer peripheral surface thereof.

On the other hand, the locking portion 16A of the syringe 101
Is formed in a substantially central portion on the front end side of the gasket 12A, and is constituted by a circular concave portion which is opened to the front end surface 121, and an inner peripheral surface thereof has a female screw 164 screwed with the male screw 61.
Are formed. The engagement between the connecting portion 6A and the locking portion 16A is performed by relatively rotating the syringe body 1A and the container 10A and screwing the male screw 61 and the female screw 164.

FIG. 10 is a plan view showing another structural example of the container according to the present invention, FIG. 11 is a vertical sectional view showing the structure of the tip portion of the container 10B shown in FIG. 10, and FIG. 12 is a gasket of the container 10B. It is a longitudinal section showing composition at the time of movement.
For convenience of explanation, the upper side in FIGS. 11 and 12 is referred to as the front end, and the lower side is referred to as the rear end.

The container 10B shown in these figures is the same as the container 10 or 10A except for the structure of the gasket and the restricting means for restricting the axial position of the gasket with respect to the container body 11. In the container 10B, the protrusion 112 is not provided on the inner peripheral surface of the container body 11.

The gasket 20 in the container 10B has a thin portion 22 similar to the above in the substantially central portion thereof, and a space 21 similar to the above is formed on the rear end side of the thin portion 22. Further, a core member 23 made of, for example, the resin as described above is embedded on the tip side of the thin portion 22 of the gasket 20. A space 24 for accommodating and holding the same encapsulating member 7 as described above, and a locking portion 25 formed of a circular recess similar to the locking portion 16A communicating with the space 24 are provided in the substantially central portion of the core member 23. Are formed. Also, the locking portion 25
The inner peripheral surface of the female thread 2 which is screwed with the male thread on the outer periphery of the connecting portion
6 is formed.

At the tip of the core member 23, there are formed three fan-shaped small pieces 27 extending radially from the center of the core member 23 at intervals of 120 °. On the other hand, a ring-shaped locking member 28 is fixed to the tip of the container body 11 by being fitted into the tip edge portion 114 of the container body 11. As shown in FIG. 11, in the inner opening of the locking member 28,
The body portion 231 of the core material 23 is inserted.

The inner opening of the locking member 28 is a portion whose diameter is substantially equal to or slightly larger than the outer diameter of the body portion 231 of the core member 23 (to correspond to the small piece 27,
3 places are formed at 120 ° intervals from the center).
It has a shape in which inner diameter enlarged portions 29 having an inner diameter larger than the diameter of a circle connecting the outermost circumferences of the respective small pieces 27 are alternately arranged along the circumferential direction. In this case, each inner diameter enlarging portion 29
Are arranged at intervals of 120 ° from the center, and their inner diameter and opening angle are larger than those of the small pieces 27.

In the state shown in FIGS. 10 and 11, the front end surface of the gasket 20 contacts the rear end surface (the inner surface of the container) of the locking member 28, and each small piece 27 of the core member 23 is
Since the locking member 28 is locked at a portion between the adjacent inner diameter enlarged portions 29 and is in a so-called locked state, the movement of the gasket 20 toward the front end side and the rear end side is restricted.

Further, the core member 23 is set to 60 with respect to the locking member 28.
When the small pieces 27 are rotated and overlapped with the corresponding inner diameter enlarging portion 29, the three small pieces 27 simultaneously pass through the inner diameter enlarging portion 29, and the movement restriction to the rear end side is released as shown in FIG. The gasket 20 can slide inside the container body 11 toward the rear end side. In addition, in the container 10 </ b> B having such a regulation means, the locking portion 25 may be replaced with the same structure as the locking portion 16.

FIG. 13, FIG. 15 and FIG. 17 are vertical cross-sectional views showing other structural examples of the container according to the present invention, and FIG.
4 and 16 are bottom views of the container shown in FIGS. 13 and 15, respectively. In each of the containers shown in these drawings, a ring-shaped rib 115 is formed on the outer periphery of the rear end portion (bottom portion) of the container body 11 and is engaged with the rib 115 to be fixed to the bottom portion of the container body 11. Gripping members (auxiliary tools for moving the container) 30A to 30C installed in the.

Gripping member 30A shown in FIGS. 13 and 14.
Has an engaging portion 300 that engages with the rib 115, and a flange 301 formed on the opposite side of the engaging portion 300.

Grasping member 30B shown in FIGS. 15 and 16.
Has an engaging portion 300 that engages with the rib 115, and a flange 302 formed on the opposite side of the engaging portion 300,
The engaging portion 300 and the flange 302 are connected by a shaft 303.

The gripping member 30C shown in FIG.
5 has an engaging portion 300 that engages with the engaging portion 5, and a concave portion 304 suitable for gripping with a finger or the like is formed on the outer periphery on the side opposite to the engaging portion 300.

In such a container, the holding members 30A-3
Since the operation of moving the container with respect to the syringe main body is performed by grasping the flanges 301 and 302 of 0C or the concave portion 304 with a finger or the like, the operation, particularly the operation of moving the container in the direction of pulling out the container from the syringe main body, can be performed easily and reliably. it can. In particular, it is effective when the length of the container body 11 is relatively short.

The shape and structure of the gripping member are not limited to those shown in the drawings. Further, in the configuration example shown in FIGS. 13 to 17, the container body 11 and the gripping members 30A to 30C are configured as separate members, but they may be integrally formed.

Although the syringe of the present invention has been described with respect to each structural example shown in the accompanying drawings, the present invention is not limited to these. For example, the configuration of the connecting portion and the locking portion is not limited to the configuration of the convex portion and the concave portion as shown in the drawing, but may be surfaces that are joined to each other, for example.
In this case, the gasket 12 can only be slid to the rear end side of the container body 11 by inserting the container body 11 into the outer cylinder.

[0086]

As described above, according to the syringe of the present invention, it is possible to inject a liquid into a bag or mix a medicine with a simple operation in a short time, and to cope with an emergency. Be advantageous. In addition, during operations such as compounding of medicines, there is very little chance that various parts of the syringe, such as the inside of the container, come into contact with the outside air, so that it is possible to prevent bacterial contamination and contamination with foreign substances.

In particular, when a plurality of drugs having different active ingredients are blended, the first needle tube of the syringe is punctured in a bag or the like, and a plurality of containers each containing a different drug are appropriately exchanged for use. The above-mentioned excellent operability and sterility-retaining effect are more effectively exhibited. Also,
When the gasket can be reciprocated in the container body by the engagement between the engagement portion and the connecting portion, the medicine in the container can be discharged without waste.

[Brief description of drawings]

FIG. 1 is a vertical sectional view showing a configuration example of a syringe body in the present invention.

FIG. 2 is a view taken along line II-II in FIG.

FIG. 3 is a vertical cross-sectional view showing a structural example of a container according to the present invention.

4 is a plan view of a gasket in the container shown in FIG.

5 is a sectional view taken along line VV in FIG.

6 is a sectional view taken along line VI-VI in FIG.

FIG. 7 is a vertical cross-sectional view showing a usage state of the syringe of the present invention.

FIG. 8 is a vertical cross-sectional view showing a usage state of the syringe of the present invention.

FIG. 9 is a partial vertical cross-sectional view showing another configuration example of the syringe of the present invention.

FIG. 10 is a plan view showing another configuration example of the container according to the present invention.

11 is a vertical cross-sectional view showing the configuration of the tip portion of the container shown in FIG.

FIG. 12 is a vertical cross-sectional view showing the configuration of the tip portion of the container shown in FIG. 10 (when the gasket is moved).

FIG. 13 is a vertical cross-sectional view showing another configuration example of the container according to the present invention.

FIG. 14 is a bottom view of the container shown in FIG.

FIG. 15 is a vertical cross-sectional view showing another configuration example of the container according to the present invention.

16 is a bottom view of the container shown in FIG.

FIG. 17 is a vertical cross-sectional view showing another configuration example of the container according to the present invention.

[Explanation of symbols]

 100, 101 Syringe 1, 1A Syringe main body 2 Outer cylinder 2a Bottom part 2b Rear end opening 2c Flange 3 First needle tube 31 Side hole 4 Tubular body 5 Second needle tube 51 Needle tip 6, 6A Connecting part 61 Male screw 7 Encapsulating member 8 film 81 tab 9 cap 10, 10A, 10B container 11 container body 111 tip opening 112 protrusion 113 bottom inner surface 114 tip edge 115 ribs 12, 12A gasket 121 tip surface 122 rear end surface 123 outer peripheral surface 13 space 14 space 15 space 16, 16A Locking part 161 Space 162 Opening 163 Locking surface 164 Female screw 17 Vent hole 18 Projection part 19 Film 20 Chemicals 21 Space 22 Thin wall part 23 Core material 231 Body part 24 Space 25 Locking part 26 Female screw 27 Small piece 28 Locking Member 29 Inner diameter enlarged portion 30A, 30B, 30C Gripping member 30 Engaging portions 301, 302 the flange 303 shaft 304 recess 105 infusion bag 106 elastic stopper 107 infusion 108 chemical 120 drug

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Junji Kimura 1500 Inokachi, Nakai-cho, Ashigarashami-gun, Kanagawa Terumo Corporation

Claims (1)

[Claims] 1. An outer cylinder and a first member installed at a tip portion of the outer cylinder.
Needle tube, a tube body installed in the outer cylinder and having a tip side communicating with the inside of the first needle tube, a second needle tube installed on the rear end side of the tube body, and a second needle tube A container including a syringe body including a connecting portion formed on an outer peripheral portion, a bottomed cylindrical container body, and a gasket capable of sliding in a liquid-tight manner along an inner surface of the container body. hand,
The gasket has at least one container in which a thin portion through which the second needle tube can be pierced and a locking portion for locking the connecting portion are formed. From the inside into the outer cylinder, the second needle tube is pierced through the thin portion of the gasket, and the container body is inserted into the syringe body while the connecting portion and the engaging portion are engaged. The syringe is characterized in that at least the liquid in the container is discharged through the first needle tube by moving relative to the axial direction and sliding the gasket in the container body.