JP3274004B2 - Syringe - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a syringe, and more particularly to a syringe used for compounding a drug solution.

[0002]

2. Description of the Related Art Prior to administration of an infusion to a patient, drugs such as vitamins, heparin and antibiotics are added to the infusion filled in the infusion bag as required. I have.

[0003] To mix such a drug, first, the puncture needle of the syringe is pierced into the elastic stopper of the infusion bag, and the plunger is pulled to collect the infusion in the infusion bag into the syringe. Transfer to a container containing the drug (powder) to be blended, dissolve and mix the drug in this container, then aspirate and collect the drug mixture again with the syringe,
This is performed by inserting a puncture needle into an elastic stopper of the infusion bag and pushing the plunger to inject the drug mixture into the infusion bag.

[0004] However, such a chemical solution is formulated
There is a disadvantage that the operation procedure is complicated and the time required for blending is long. In particular, prompt response is essential for emergency patients, but it is disadvantageous when formulating a drug solution to be administered to such patients.

Furthermore, since the compounding operation of the above-mentioned chemical solution, particularly the dissolution and mixing of the chemical, are mostly performed in contact with the atmosphere, there is a risk of bacterial contamination and foreign matter contamination. In addition, when a plurality of types of drugs are compounded, the above-mentioned drawbacks have become more remarkable because the above-described compounding operation is repeated.

[0006]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a syringe which can perform injection and compounding of a medicine by a simple operation in a short time without causing contamination.

[0007]

This and other objects are attained by the present invention which is defined below as (1) to (21).

(1) A syringe body having a tube, and at least one container connectable to one end of the tube, wherein the container has a bottomed cylindrical container body, and an inside of the container body. A plurality of gaskets that are arranged to partition the plurality of spaces, and that can slide in a liquid-tight manner along the inner surface of the container body, and a needle tube installed in at least the gasket on the opening side of the container body among the gaskets. The container body is moved in the axial direction relative to the syringe body in a state where the lumen of the tube body and the space are communicated via the needle tube, and the gasket is moved to the container body. A syringe for discharging at least a substance in the space through the needle tube and the tube body by sliding the inside of the syringe.

(2) The syringe according to the above (1), further comprising means for communicating adjacent spaces among the plurality of spaces. (3) The syringe according to (1) or (2), wherein each of the gaskets has a needle tube.

(4) The syringe according to any one of the above (1) to (3), wherein the syringe body has another needle tube at the distal end side of the tube.

(5) The syringe body is liquid-tightly fixed to a flexible bag so that the lumen of the tubular body and the inside of the bag can communicate with each other. ).

(6) The syringe according to any one of (1) to (5), wherein the syringe body has an outer cylinder on the outer periphery of the tube body, into which the container can be inserted.

(7) The syringe according to the above (6), further comprising a film for sealing an opening on a rear end side of the outer cylinder.

(8) The syringe according to any one of the above (1) to (7), wherein the syringe body has sealing means for sealing the inner cavity of the tube so as to be openable.

(9) The syringe according to the above (8), wherein the sealing means is a film provided on a rear end side of the tubular body and penetrable by a needle tube provided on the gasket.

(10) The above (1) to (9), wherein the tube has a connecting portion on the rear end side, and the gasket on the opening side of the container body has a locking portion for locking with the connecting portion. The syringe according to any one of the above.

(11) The syringe according to the above (10), wherein the gasket can reciprocate in the container body by locking the connecting portion and the locking portion.

(12) The connecting part and the locking part are
The syringe according to the above (10) or (11), wherein the syringe is locked and released by relatively rotating them.

(13) The syringe according to any one of the above (1) to (12), further comprising a restricting means for restricting an axial position of the gasket with respect to the container body.

(14) There is provided a fitting portion in which adjacent gaskets in the container main body are fitted with each other, and the fitting of the fitting portion allows both gaskets to slide integrally. The syringe according to any one of 13).

[0021]

(15) The syringe according to any one of (1) to (14), further comprising a covering member for covering the needle tube provided on the gasket and penetrating the needle tube.

(16) The syringe according to any one of the above (1) to (15), further comprising a film for sealing an opening of the container body.

(17) The syringe according to any one of (1) to (16), wherein the substance in each space is a solid or liquid drug.

(18) The above-mentioned (1), wherein at least two of the spaces contain substances having different components.
Or the syringe according to any one of (17) to (17).

(19) The syringe according to any one of (1) to (18), wherein the inside of the container is in a reduced pressure state.

(20) A needle tube having needle tips at both ends is installed in the gasket on the opening side of the container main body, and a gasket adjacent to this is formed with a film penetrable by the needle tube. The syringe according to any one of (1) to (19).

(21) The syringe according to any one of (1) to (20), wherein a gripping member is mounted on a bottom of the container body.

[0029]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, a syringe according to the present invention will be described in detail based on a preferred embodiment shown in the accompanying drawings. The syringe of the present invention includes a syringe main body 1A and a container 10A. Hereinafter, these configurations will be sequentially described.

FIG. 1 is a longitudinal sectional view showing an example of the configuration of a syringe body according to the present invention, and FIG. 2 is a view taken along the line II-II in FIG. For convenience of description, the upper side in FIG. 1 is referred to as a front end, and the lower side is referred to as a rear end. As shown in FIG. 1, the syringe main body 1A has a cylindrical outer cylinder 2 having a bottom 2a on the distal end side, and a needle tube 3 protruding from the bottom 2a is installed at the distal end of the outer cylinder 2. I have.

The needle tube 3 in the configuration example shown in FIG.
A bottle needle pierced by an elastic stopper 106 that seals the opening of the infusion bag 105 (see FIGS. 6 and 7), and a plurality of sides communicating with the lumen of the needle tube 3 are provided on the side near the tip. A hole 31 is formed. The needle tube 3 is not limited to a bottle needle as shown, but may be a normal metal puncture needle or the like.

In the outer cylinder 2, a tube 4 is installed substantially concentrically with the outer cylinder 2. In this case, the length of the tube 4 is
, That is, the rear end of the tube 4 is located inside the outer cylinder 2 from the rear end opening 2 b of the outer cylinder 2.

The lumen 41 of the tube 4 communicates with the lumen of the needle tube 3 on the distal end side. In the illustrated example, the tube 4 is formed integrally with the needle tube 3, and the bottom 2 a of the outer tube 2 is formed.
Is preferably fixed by fusion or adhesion.

A connecting portion 6A is formed on the rear end side of the tube 4, and an enlarged diameter portion 42 in which the inner cavity 41 is enlarged is formed near the connecting portion 6A. The enlarged diameter portion 42 is a portion into which the distal end portion of the needle tube 16 described later is inserted (see FIG. 6). Therefore, the inner diameter of the enlarged diameter portion 42 is larger than the outer diameter of the needle tube 16.

The connecting portion 6A of the tube 4 has a bore 41 formed therein.
A film 7 for sealing the rear end opening of the large-diameter portion 42 is stretched as a sealing means for sealing the opening. This film 7
It can be pierced by a needle tube 16 described later, for example, various rubber materials such as natural rubber, isoprene rubber, butadiene rubber, silicone rubber, latex rubber, polyvinyl chloride, polyethylene, polypropylene, ionomer, polyethylene terephthalate, etc. Polyester, polystyrene, poly- (4-methylpentene-
1), a single layer made of various resins such as polyamide, or a metal foil such as an aluminum foil, or a laminate obtained by laminating (laminating) two or more layers of these is preferably used.

Between the rear end surface of the tube 4 and the membrane 7, when a needle tube 16 described later is pierced through the membrane 7, the needle tube 16 is brought closer to the base (rear end) side of the needle tube 16 and deformed into a bellows shape. A space 5 for accommodating and holding the compressed envelope member 18 is formed.

The constituent materials of the outer cylinder 2, the needle tube 3 and the tube body 4 include, for example, polyvinyl chloride, polyethylene, polypropylene, polystyrene, poly- (4-methylpentene-1), polycarbonate, acrylic resin, acrylic resin Various resins such as nitrile-butadiene-styrene copolymer, polyester such as polyethylene terephthalate, butadiene-styrene copolymer, polyamide (eg, nylon 6, nylon 6.6, nylon 6.6, nylon 12, nylon 12), alumina, etc. Among them, polypropylene, polyester and poly- (4
Preference is given to resins such as -methylpentene-1). In addition, these materials, in order to ensure the visibility of the inside,
Preferably, it is substantially transparent.

A plate-like flange 2c is formed integrally with the outer cylinder 2 around the rear end opening 2b of the outer cylinder 2. When a container 10A described later is inserted into the outer cylinder 2 or pulled out from the outer cylinder 2, a finger is placed on the flange 2c to fix the syringe body 1A.

Further, in the syringe body 1A when not in use, the rear end face of the outer cylinder 2 is provided on the rear end face of the flange 2c.
Is preferably stuck to a film 8 for hermetically sealing. Thereby, contamination inside the syringe main body 1A is prevented, and sterility is maintained. When using the syringe body 1A, the film 8 is peeled off. At this time, tabs 81 are provided at the edges of the film 8 so that the film 8 can be easily peeled off.
Are formed.

As the film 8, a single layer made of a resin such as polyethylene, polypropylene, ionomer, polyester such as polyethylene terephthalate, polystyrene, poly- (4-methylpentene-1), polyamide, or a metal foil such as an aluminum foil is used. Or a laminate obtained by laminating (laminating) two or more of these layers. Since the laminate of the metal foil and the resin layer has low gas permeability, the use of such a film 8 improves the hermeticity of the outer cylinder 2 and effectively prevents invasion of bacteria and the like. It is preferable because it is possible.

A cap 9 that covers the needle tube 3 is attached to the distal end of the outer cylinder 2. The cap 9 has a function of preventing danger and preventing contamination of the needle tube 3. In addition, in the syringe of the present invention, unlike the illustrated syringe main body 1A, the length of the tube 4 is longer than the length of the outer cylinder 2, that is,
The rear end of the tube 4 may be configured to protrude outside the outer cylinder 2 from the rear end opening 2b of the outer cylinder 2. In addition, syringe body 1A
May not have the outer cylinder 2. Further, the films 8, 25 and the cap 9 may be provided as necessary, respectively, and these may not be present.

FIG. 3 is a longitudinal sectional view showing a configuration example of the container in the present invention. For convenience of explanation, the upper side in FIG. 3 is referred to as a front end, and the lower side is referred to as a rear end. The container 10A shown in FIG.
Used in combination with the syringe body 1A,
It is mainly composed of a bottomed cylindrical container body 11 having an open end, and two first gaskets 12 and a second gasket 19 that can slide in a liquid-tight manner along the inner surface of the container body 11. .

The container body 11 is made of the same resin material or glass material as the outer cylinder 2 and the like, and is preferably substantially transparent in order to ensure the visibility of the inside. The outer diameter of the container body 11 is smaller than the inner diameter of the outer cylinder 2, and
The inner diameter of the container body 11 is larger than the tube 4. Thereby, the container main body 11 can be inserted to the inner part of the outer cylinder 2.

The total length of the container body 11 is preferably substantially equal to or greater than the total length of the outer cylinder 2.
In particular, when the container main body 11 is inserted to the innermost part of the outer cylinder 2 so that the liquid medicines 150 and 151 in the container 10A can be discharged as much as possible regardless of the posture of the container 10A, the first gasket 12 And 19 are connected so that the rear end surface 192 of the gasket 19 can contact the bottom inner surface 113 of the container body 11.

A first gasket 12 is provided in the container body 11.
And a second gasket 19 are housed at predetermined intervals, and the interior of the container body 11 is partitioned into a first space 117 and a second space 118 by these gaskets 12 and 19.

The first gasket 12 is made of various rubber materials (especially vulcanized) such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, silicone rubber, polyurethane, and polyester. It is a substantially columnar member made of an elastic material such as various elastomers such as polyamide, olefin, and styrene, or a mixture thereof. The first gasket 12 is not limited to the whole made of the above-described material, but may be one in which at least the protrusion 13 and the enclosing member 18 are made of the above-described material.

An engaging portion 14A is formed on the tip end of the first gasket 12. The locking portion 14A is formed of a concave portion having a circular cross section into which the connecting portion 6A can be inserted or fitted. Further, a needle tube 16 is provided upright at a central portion in the locking portion 14A. The needle tube 16 has a flange 162 at the rear end, and is fixed by embedding the flange 162 in the first gasket 12 on the rear end side from the bottom surface 141 of the locking portion 14A.

The side of the needle tube 16 near the distal end is provided with the needle tube 1.
A plurality of side holes 161 communicating with the 6 lumens are formed. The rear end of the lumen of the needle tube 16 is a space 17 having an enlarged diameter.
The space 17 communicates with the first space 117 via a small hole 171 that is open to the rear end face 122. An enclosing member 18 that encloses at least the distal end of the needle tube 16 is provided around the needle tube 16. The encapsulating member 18 has a role of preventing contamination of the needle tube 16 when not in use and a role of preventing liquid leakage from the side hole 161.

As the encapsulating member 18, a member made of a film made of the same material as that of the first gasket 12 and easily penetrated by the tip of the needle tube 16 is preferably used. Further, the rear end of the enclosing member 18 is preferably joined or integrated with the bottom surface 141 of the locking portion 14A. It is preferable that the distal end of the needle tube 16 and the distal end of the enclosing member 18 do not protrude distally from the distal end surface 121 of the first gasket 12.

The rear end face 122 of the first gasket 12 has a concave curved surface in which the vicinity of the small hole 171 at the center is most concave. The rear end face 122 is not limited to such a shape, and may be, for example, a flat surface or a convex curved surface.

On the outer peripheral surface 123 of the first gasket 12,
A plurality of ring-shaped protrusions 13 are formed over the entire circumference. When the first gasket 12 slides, the projection 13 has a function of closely adhering to the inner peripheral surface of the container body 11 and maintaining airtightness and maintaining appropriate slidability.

The second gasket 19 is a substantially columnar member made of the same material as the first gasket 12. It should be noted that the second gasket 19 is not limited to the whole made of the above-described material, and at least the protrusion 20
And the encapsulating member 24 may be made of the above material.

At the center of the second gasket 19, the needle tube 2
1 is erected. The needle tube 21 has a collar 21 at its rear end.
2 and is fixed by embedding the flange portion 212 in the second gasket 19 on the rear end side of the concave portion 23 described later. A needle tube 21 is provided on a side portion near the distal end of the needle tube 21.
Are formed with a plurality of side holes 211 communicating with the inner cavity.
The rear end of the lumen of the needle tube 21 communicates with the second space 118 via the space 22 opened to the rear end face 192.

An encapsulating member 24 similar to the encapsulating member 18 enclosing at least the distal end of the needle tube 21 is provided around the needle tube 21. The wrapping member 24 is
When A is not used or when the liquid in the first space 117 is discharged, the communication between the first space 117 and the second space 118 is cut off, and the liquid flows between them.

Further, on the distal end side of the second gasket 19 and on the outer peripheral portion of the encapsulating member 24,
3 are formed. In the concave portion 23, the encapsulating member 24 which is moved toward the base (rear end) side of the needle tube 21 and deformed and compressed into a bellows shape is stored and held.

The distal end face 191 of the second gasket 19 has a shape which can be in close contact with the rear end face 122 of the first gasket 12 when the two gaskets 12 and 19 are connected, that is, a curved surface whose center portion protrudes most in the distal direction. Has made.
Thereby, the liquid in the first space 117 can be efficiently discharged with almost no remaining.

The rear end surface 192 of the second gasket 19
Has a flat surface so that it can be in close contact with the bottom inner surface 113 of the container body 11. Thereby, the second space 1
The liquid in 18 can be efficiently discharged with almost no remaining.

On the outer peripheral surface 193 of the second gasket 19,
As described above, a plurality of ring-shaped protrusions 20 are formed over the entire circumference. This projection 20 has a function of keeping close contact with the inner peripheral surface of the container main body 11 when the second gasket 19 slides, maintaining airtightness, and maintaining appropriate slidability as described above. ing.

The outer diameters of the needle tubes 16 and 21 are not particularly limited, but are preferably about 0.1 to 5 mm, particularly preferably about 0.5 to 3 mm. Needle tubes 16 and 21, flanges 162 and 212
The same material as that of the needle tube 3, particularly a hard resin, or a metal material such as stainless steel, titanium, and aluminum can be used as the material for the above. Needle tube 16,
21 is not limited to a bottle needle type as shown in the figure, but may be a normal metal puncture needle or the like.

In the container 10A when not in use, a film 25 for sealing the tip opening 111, preferably in a gas-tight manner, is attached to the tip of the container body 11. This allows
Contamination of the first gasket 12 is prevented, and sterility is maintained. When the inside of the container 10A is kept in a decompressed state when not in use, by using the gas impermeable film 25, even when the encapsulating member 18 is not provided, the tip opening 11
1 is obtained, which is advantageous for maintaining a reduced pressure in the container 10A. As the film 25, the same film as the film 8 can be used.

The first space 117 and the second space 118 of the container 10A may be empty when the container 10A is not used, but it is usually preferable that a predetermined amount of medicine is previously stored. The drug may be liquid or solid (including semi-solid). In the container 10A, the first space 117 and the second space 118 are filled with the drug solutions 150 and 151, respectively. In this case, it is preferable that the chemical solutions 150 and 151 have different components (compositions), and particularly have different effective components.

Specific examples of the drug solutions 150 and 151 include vitamins (multivitamins), various amino acids, antithrombotic agents such as heparin, insulin, antibiotics, antitumor agents, analgesics, inotropic agents, intravenous anesthetics , Anti-parkinsonian,
Ulcer treatment agents, corticosteroids, arrhythmia agents, correction electrolytes and the like.

In the container 10A as described above, the container body 1
1 has a function as a plunger for moving the first gasket 12 and the second gasket 19 with respect to the container body 11, and the first space 117 in which the first gasket 12 and the second gasket 19 are sealed. And the function of forming the second space 118 and the function of obtaining communication / interruption with the inside of the tube 4. Therefore, the container 10A can be composed of only the container body 11 and the two gaskets 12, 19, which are the minimum necessary members, and the number of parts is smaller than that of a conventional container having a rubber stopper and a plunger rod dedicated to needle tube insertion. , The structure is extremely simple, and the operation is easy. It is preferable that at least the inside of the syringe main body 1 and the container 10A have been previously subjected to a sterilization treatment such as high-pressure steam sterilization, gas sterilization or radiation sterilization.

FIGS. 4 and 5 are longitudinal sectional views showing other structural examples of the syringe body and the container according to the present invention, respectively. FIGS. 6 and 7 are syringe body 1B and container 10B shown in FIGS. 4 and 5, respectively. It is a longitudinal cross-sectional view which shows the use condition of the syringe 100 comprised by this. Hereinafter, with respect to the syringe 100 shown in these figures, points different from the configurations shown in FIGS. 1 to 3 will be described, and description of the same items will be omitted. For convenience of description, the upper side in FIGS. 4 to 7 is referred to as a front end, and the lower side is referred to as a rear end.

Syringe body 1B constituting syringe 100
As shown in FIG. 4, has a tube 4 similar to the above, and has a connecting portion 6B formed at the rear end side. The connecting portion 6B is formed of a columnar convex portion having a circular cross section having an enlarged diameter portion 42 inside, and a male screw 61 is formed on the outer periphery thereof. The connecting portion 6B may be formed integrally with the tube 4 or may be formed by joining another member.

On the other hand, the container 10B constituting the syringe 100
As shown in FIG. 5, the gasket comprises a container body 11, a first gasket 12, and a second gasket 19, similar to those described above. An engaging portion 14B is formed. A female screw 15 that can be screwed with a male screw 61 on the outer periphery of the connecting portion 6B is formed on the inner peripheral surface of the locking portion 14B.

In such a syringe 100, since the syringe main body 1B and the container 10B are relatively rotated to screw the connecting portion 6B and the locking portion 14B, the container main body 11 reciprocates with respect to the syringe main body 1B. When this is done, it becomes possible to reciprocate the first gasket 12 in the container body 11 accordingly.

FIGS. 8, 9, 10 and 11 are longitudinal sectional views showing still another example of the structure of the container according to the present invention. The containers 10C, 10D, 1
0E and 10F are respectively the syringe main body 1B shown in FIG.
Used in combination with Hereinafter, with respect to these containers, differences from the configuration of the container 10B shown in FIG. 5 will be described, and description of the same items will be omitted. In addition,
For convenience of description, the upper side in FIGS. 8 to 11 is referred to as a front end, and the lower side is referred to as a rear end.

The container 10C shown in FIG. 8 is different from the container body 11 in the configuration. That is, the inner surface of the container body 11 is located along the inner periphery of the container body 11 at a position spaced a predetermined distance from the front end opening 111 to the rear end and at a position separated from the bottom inner surface 113 by a predetermined distance toward the front end. Ring-shaped protrusions 112 and 114 are formed. In this case, the formation position of the protrusion 112 is, for example, a position where at least the front end surface 121 of the first gasket 12 does not protrude from the front end opening 111 of the container body 11, and the formation position of the protrusion 114 is For example, the first space 117
The gasket 19 is positioned so that the gasket 19 and the second space 118 have the same volume.

The projection 112 is engaged with the rear end face 122 of the first gasket 12 so that the container body 11 of the first gasket 12
Is a restricting means for restricting the axial position of the second gasket 19 with respect to the rear end surface 192 of the second gasket 19.
To restrict the axial position of the second gasket 19 with respect to the container body 11.

That is, the protrusion 112 is formed in the first space 117.
Is in a depressurized state, a role of preventing the first gasket 12 from moving to the rear end side of the container body 11 due to a pressure difference from the atmospheric pressure, and connecting the connecting portion 6B and the locking portion 14B (screw connection). ) To prevent the first gasket 12 from being pressed and moved to the rear end side of the container body 11 due to the penetration resistance of the needle tube 16 or the like, or to move the first gasket 12 to the front end side of the container body 11. The first gasket 12 serves to prevent the first gasket 12 from easily coming off from the container body 11 when the container 10C is moved to or when the container 10C is withdrawn from the syringe body 1B.

The projection 114 prevents the second gasket 19 from moving toward the rear end of the container body 11 due to the pressure difference when the pressure in the second space 118 is lower than the pressure in the first space 117. When connecting the two gaskets 12, 19, the second gasket 19 is prevented from being pressed and moved to the rear end side of the container body 11 by the penetration resistance of the enclosing member 24 by the needle tube 21 or the like. Fulfill.

The restricting means is not limited to the projections 112 and 114 formed on the container body 11, but may be, for example, a lock mechanism for locking and releasing the first gasket 12 at the tip of the container body 11. .

In such a container 10C, the first space 11
7 and the second space 118 contain solid medicines 152 and 153, respectively. In this case, the drug 152,
153 preferably have different components (compositions), particularly preferably different active components.

Representative examples of the solid drug include a tablet or a powder (granule) drug as shown in the figure.
A powder is preferred because it is easily dissolved or dispersed by the liquid introduced into the container 10C. Such powdery medicines 152 and 153 can be easily obtained by, for example, freeze-drying.

The medicines 152 and 153 are respectively
Usually, it is composed of a single active ingredient, but may be a combination preparation containing two or more active ingredients. Drugs 152, 15
Specific examples of 3 include those similar to the chemicals 150 and 151.

Further, in the present invention, since the drug solution 150 or the drug 152 stored in the first space 117 and the drug solution 151 or the drug 153 stored in the second space 118 are stored in a non-contact manner, they are brought into contact with each other. This is advantageous when the substance is liable to react and deteriorate.

Also, like the container 10C, the first space 11
When the solid medicine is put in the seventh space 118 and the second space 118, the first space 117 and the second space 118 may be in a state almost equal to the atmospheric pressure, but may be in a reduced pressure state (for example, 0.1 to 760 mmHg). ).

Note that, inside the first gasket 12 and the second gasket 19, one ends are spaces 17, 2, respectively.
At least one vent hole (not shown) that opens to the second or rear end surfaces 122 and 192 and the other end to the outer peripheral surfaces 123 and 193 may be formed. This vent hole is for discharging water vapor when the medicines 152 and 153 placed in the container 10C are lyophilized. Therefore,
The ventilation holes are provided as needed according to the form of the medicine stored in the container 10A.

Further, in order to prevent the solid medicines 152 and 153, which have not been completely dissolved or dispersed in the container 10C, from being discharged from the side hole 31 of the needle tube 3, the lumen 41 of the tube 4 and the needle tube 16 are prevented. , 21 or a space (17, 22), a filter (not shown) for blocking the passage of a solid drug can be provided. Examples of the filter include a membrane filter, a mesh, a woven fabric, and a nonwoven fabric.

The container 10D shown in FIG.
It is the same as the above-mentioned container 10C except that it has a fitting portion where 2, 19 fit each other. That is, the second gasket 19
A plurality of fitting protrusions 26 a having a hemispherical head protruding toward the front end side of the second gasket 19 are provided on the outer peripheral portion of the concave portion 23, while each fitting protrusion 26 a on the rear end side of the first gasket 12 is provided. At a position corresponding to the projection 26a, the fitting projection 26
A fitting hole 26b into which the head of a can be fitted is formed.
A fitting portion is formed by the fitting protrusion 26a and the fitting hole 26b.

When the fitting projections 26a of the second gasket 19 are fitted into the corresponding fitting holes 26b, the two gaskets 12, 19 are connected and integrated. When reciprocating within the first gasket 11, the second gasket 19 also slides integrally with the first gasket 12. As a material for the fitting protrusion 26a, the same material as that of the needle tube 3, particularly a hard resin, or a metal material such as stainless steel, titanium, and aluminum can be used.

The container 10E shown in FIG. 10 is the same as the container 10D, except that the structure of the fitting portion in which the two gaskets 12, 19 are fitted is different. That is, the annular member 27 is formed to extend from the rear end side of the flange portion 162 of the first gasket 12, and the rear end side of the annular member 27 is located within the first space 117 from the rear end surface 122 of the first gasket 12. Projecting to A ring-shaped or band-shaped fitting projection 27a is formed on the outer periphery of the projecting portion. On the other hand, on the inner peripheral wall surface forming the concave portion 23 of the second gasket 19,
A fitting groove 27b into which the fitting protrusion 27a can fit is formed. The fitting protrusion is formed by the fitting protrusion 27a and the fitting groove 27b.

A space 17, a small hole 171 and a space 172 are formed inside the annular member 27. Space 172
Inside, when the distal end portion of the needle tube 21 is inserted into the space 17, the envelope member 24, which is moved toward the base portion (rear end) of the needle tube 21 and deformed and compressed into a bellows shape, is stored and held therein. .

When the projecting portion on the rear end side of the annular member 27 is inserted into the concave portion 23 of the second gasket 19 and the fitting projection 27a is fitted in the fitting groove 27b, both gaskets 12 and
Since the first gasket 12 is reciprocated in the container body 11, the second gasket 19 slides integrally with the first gasket 12.
The configuration of the fitting portion is not limited to the configuration shown in FIGS. 9 and 10, but may be any configuration as long as both gaskets 12, 19 can slide integrally.

The container 10F shown in FIG. 11 is different from the container 10F in that the two gaskets 12, 19 housed in the container body 11 having the same protrusions 112, 114 as described above. That is, the flange portion 16 of the first gasket 12
A needle tube 28 similar to the needle tube 16 is provided on the rear end side of the needle tube 1.
6 is formed in the opposite direction. This needle tube 28 is
The gasket 12 protrudes from the rear end face 122 into the first space 117, and the side of the needle tip (rear end) near the needle tube 2
A plurality of side holes 281 communicating with the 8 lumens are formed.

On the other hand, near the center of the second gasket 19, a film 29 that can be pierced by the needle tube 28 is formed. A space 291 is formed on the rear end side of the film 29,
Further, on the rear end side of the space 291, a passage 292 is formed to be open to the rear end face 192 of the second gasket 19.
The two gaskets 12 and 19 are connected, and the needle tube 28 is connected to the membrane 29.
Piercing the second space 118, the passage 292, the space 2
It communicates with the lumen of the needle tube 16 through the lumen 91, the side hole 281, and the lumen of the needle tube 28.

Note that, in the container 10F, FIGS.
The gasket 12 and the gasket 12 may be formed with a fitting portion as shown in FIG. 4. In the case where the first space 117 and the second space 118 are respectively filled with a chemical solution, the container body 11 May not have the protrusions 112 and 114.

Also, in the containers 10C to 10F, similarly to the container 10B, the first space 117 and the second space
One or both of the 18 may be filled with a chemical solution.

Next, an example of a method of using the syringe 100 of the present invention will be described with reference to FIGS. Usage when both spaces 117 and 118 of container 10B are pre-filled with a chemical solution

[1] First, as shown in FIG. 6, the cap 9 is removed, and the needle tube 3 of the syringe 100 is pierced through the elastic stopper 106 which seals the opening of the infusion bag 105 where the medicine is to be compounded.

[2] Next, the films 8 and 25 are respectively peeled off, and the container 10B is inserted into the outer cylinder 2 from the front end side through the rear end opening 2b of the outer cylinder 2, and the syringe main body 1B and the container 1B are inserted.
0B is relatively rotated to screw the connecting portion 6B and the locking portion 14B. With this screwing, the distal end of the needle tube 16 pierces the distal end of the encapsulating member 18 and further penetrates the membrane 7, and the side hole 1
The needle tip portion including 61 is inserted into the enlarged diameter portion 42. In this way, the inside of the first space 117 of the container 10B and the lumen 41 of the tube 4 communicate with each other via the needle tube 16 and the like.

Note that the needle tube 16 is made up of the envelope member 18 and the membrane 7.
When the piercing is performed, the encapsulating member 18 does not exceed the membrane 7, so that the encapsulating member 18 is moved toward the rear end side of the needle tube 16 and compressed and deformed in a bellows shape. It is stored and held inside.

[3] Next, as shown in FIG.
0B is pressed in the direction of the front end, so that the container body 1
1 is inserted into the outer cylinder 2. Connecting part 6B and locking part 14
B and the first gasket 12 are
Only the container body 11 and the second gasket 19 move in the distal direction while being connected to the rear end. As a result, the volume of the first space 117 is reduced, and the liquid medicine 150 in the first space 117 is filled with the small hole 171, the space 17, the lumen of the needle tube 16 and the side hole 161, as shown by the arrow in FIG. Enlarged portion 42 and lumen 41 of tube 4, lumen of needle tube 3 and side hole 31
Are sequentially injected into the infusion bag 105 and the infusion 10
7

When the chemical 150 is injected, the second space 118 is divided into the first space 1 by the enclosing member 24.
17, the second gasket 1
9 does not move with respect to the container body 11. Further, when the container body 11 is pressed and inserted into the outer cylinder 2, the inner surface of the outer cylinder 2 serves as a guide (guide surface), and the container body 11 is moved without swinging or tilting. The tube 4 can be reliably moved in the axial direction.

[4] In the chemical liquid injection operation of the above [3], the container body 11 is inserted into the outer cylinder 2 until the rear end face 122 of the first gasket 12 approaches or contacts the front end face 191 of the second gasket 19. Even if this is the case, the drug solution 150 remains in the concave portion 23 and the like, so that the entire amount of the drug solution 150 cannot be injected into the infusion bag 105 by a single push-in operation of the container 10B.

When the container body 11 is inserted into the outer cylinder 2 to a certain depth, on the contrary, the container body 11 is pulled to the rear end side, and the infusion 107 in the infusion bag 105 is transferred to the container 10B along the same route as described above. The remaining chemical solution 150 introduced into the first space 117 is diluted, and the container body 11 is pressed and inserted into the outer cylinder 2 again. By repeating such reciprocation of the container body 11 several times, the chemical solution 150 can be supplied into the infusion bag 105 without waste, and
An accurate amount of the drug can be compounded.

When the container body 11 has the protrusion 112 (see FIGS. 8 to 11), when the first gasket 12 slides in the container body 11, the protrusion 13 exceeds the protrusion 112 of the container body 11. Sometimes, a predetermined resistance is applied, so that the first gasket 12 is prevented from being accidentally removed from the container body 11. The operation [4] may be omitted as necessary.

[5] As shown in FIG. 7, the rear end face 122 of the first gasket 12
The container main body 11 is inserted into the outer cylinder 2 until it comes into contact with 91. Accordingly, the tip of the needle tube 21 pierces the tip of the encapsulating member 24, passes through the small hole 171, and the needle tip including the side hole 211 is inserted into the space 17. Thus, the second space 118 of the container 10B communicates with the lumen 41 of the tube 4 via the needle tubes 21 and 16 and the like.

The needle tube 21 pierces the enclosing member 24,
When passing through the small hole 171, the encapsulating member 24
1, the encapsulating member 24 is moved toward the rear end side of the needle tube 24, compressed and deformed in a bellows shape, and housed and held in the concave portion 23 in this state.

[6] Next, as shown in FIG.
0B is pressed in the direction of the front end, so that the container body 1
1 is inserted into the outer cylinder 2. At this time, since the first gasket 12 and the second gasket 19 are connected, only the container body 11 moves in the distal direction. As a result, the volume of the second space 118 is reduced, and the liquid medicine 151 in the second space 118 is filled with the space 22, the lumen of the needle tube 21, the side hole 211, the space 17, and the needle tube as shown by arrows in FIG. 16 and the side hole 161, the enlarged diameter portion 42 of the tube 4 and the lumen 4
1. Injected into the infusion bag 105 through the lumen of the needle tube 3 and the side hole 31 sequentially, and mixed with the infusion 107.

When the container body 11 is pressed and inserted into the outer cylinder 2, the inner surface of the outer cylinder 2 serves as a guide (guide surface), and does not swing or tilt. The main body 11 can be reliably moved in the axial direction of the tube 4.

[7] In the chemical liquid injection operation of the above [6], the rear end face 192 of the second gasket 19 is
Even if the container main body 11 is inserted into the outer cylinder 2 until it comes into contact with the bottom inner surface 113 of the
2. Since the drug solution 151 remains in the needle tubes 3, 16, 21 and the spaces 17, 22 and the like, the entire amount of the drug solution 151 cannot be injected into the infusion bag 105 by a single push-in operation of the container 10B.

Therefore, in a container having a fitting portion such as the containers 10D and 10E (see FIGS. 9 and 10), the two gaskets 12, 19 are connected and integrated by fitting the fitting portion. When the container body 11 is inserted to a certain depth into the inside, the container body 11 is pulled backward to the rear end side, and the infusion 107 in the infusion bag 105 is introduced into the second space 118 along the same route as described above to remain. Diluting the chemical solution 151
The container body 11 is pressed and inserted into the outer cylinder 2 again. By repeating such reciprocation of the container body 11 several times, the drug solution 151 can be supplied into the infusion bag 105 without waste, and a precise amount of drug can be mixed. The operation [7] may be omitted as necessary.

[8] When a drug having a different component is further mixed into the infusion bag 105, the container 10B is moved in the opposite direction to the syringe body 1B with the needle tube 3 pierced through the elastic stopper 106 of the drug solution bag 105. Rotate to the connecting part 6
The container 10B is removed from the syringe body 1B by unscrewing the screw B and the locking portion 14B, and then a similar container containing a drug to be newly blended is set in the same manner as in [2] above. , And thereafter [3] to [7]
Perform the same operation as.

Note that the used container 10B is
In order to minimize the amount of residual liquid in B, the rear end surface 192 of the second gasket 19 is
It is preferable to remove the syringe body 1B from the syringe main body 1B while being in contact with or approaching the same. In addition, the connecting portion 6B and the locking portion 1
When the screwing with 4B is released, the needle tube 16 is withdrawn from the membrane 7, but the envelope member 18 that has been compressed in a bellows shape is restored to its original shape instantaneously and envelopes the distal end of the needle tube 16. The liquid is prevented from leaking from the side holes 161 and scattered around.

As described above, according to the syringe 100 of the present invention, a plurality of drugs having different components can be mixed in one container 10B. Then, the operation is performed by the connecting unit 6.
Since the container body 11 is simply pushed in to the front end side or the container body 11 is further pulled back to the rear end side after the engagement between B and the engaging portion 14B, it is extremely simple and the time required for blending is short.

[0108] Further, in blending a plurality of kinds of drugs,
Since the combination of drugs to be blended and their amounts are set in advance, there is no mistake in blending the drugs. Further, in the case of such a compounding agent, the chance of contact with the outside air is extremely small, and there is no possibility of bacterial contamination or foreign matter contamination.

[0109] A solid drug is stored in advance in both spaces 117, 118 of the container 10C.
How to use when the inside of 18 is pre-pressurized

First, the operations [1] and [2] are performed. By performing the operation [2], the inside of the first space 117 and the pipe 4
Is communicated via the needle tube 16 and the like, but since the inside of the first space 117 is previously depressurized, the infusion 107 in the infusion bag 105 is caused by a pressure difference from the atmospheric pressure.
It is introduced into the first space 117 through the side hole 31, the lumen of the needle tube 3, the lumen 41 and the enlarged diameter portion 42 of the tube 4, the side hole 161, the lumen of the needle tube 16, the space 17, and the small hole 171 sequentially. Is done.

Next, the container 152 is shaken or vibrated to dissolve or disperse the drug 152 in the infusion introduced into the first space 117 to obtain a drug solution containing the active ingredient of the drug 152. In addition, as this chemical | medical solution, the solution, suspension (emulsion) of the chemical | medical agent 152, etc. are mentioned.

Next, the above operations [3] to [5] are performed.
Here, when the operation [5] is performed, the inside of the second space 118 and the lumen 41 of the tubular body 4 communicate with each other via the needle tubes 21 and 16 and the like, but the inside of the first space 117 is previously depressurized. Due to the pressure difference from the atmospheric pressure, the infusion 107 in the infusion bag 105 is transferred to the side hole 31, the lumen of the needle tube 3, the lumen 41 and the enlarged diameter portion 42 of the tube 4, the side hole 161, the needle tube 16. Lumen,
Space 17, side hole 211, lumen of needle tube 21 and space 22
Are sequentially introduced into the second space 118.

Next, the container 10C is shaken or vibrated to dissolve or disperse the drug 153 in the infusion introduced into the second space 118, thereby obtaining a drug solution containing the active ingredient of the drug 153. In addition, as this chemical | medical solution, the solution, suspension (emulsion) of the chemical | medical agent 153, etc. are mentioned. Thereafter, the above operations [6] to [8] are performed.

A solid drug is stored in advance in both the spaces 117 and 118 of the container 10D.
Usage when pressure of 18 is almost equal to atmospheric pressure

First, the films 8 and 25 are peeled off, and the container 10D is inserted into the outer cylinder 2 from the front end side through the rear end opening 2b of the outer cylinder 2, and the connecting portion 6B and the engaging portion 14B are inserted in the same manner as described above. And the needle tip portion including the side hole 161 of the needle tube 16 is positioned in the enlarged diameter portion 42.

Next, the container body 11 is pressed in the distal direction, and the container body 11 is inserted into the outer cylinder 2 to reduce the volume of the first space 117. In this case, the moving distance of the first gasket 12 in the container main body 11 is, for example, such that the front end of the enclosing member 24 does not contact the rear end face 122 of the first gasket 12.

Next, the cap 9 is removed, and the needle tube 3 is inserted through the elastic stopper 106 of the infusion bag 105. This operation may be performed before the operation of inserting the container body 11 into the outer cylinder 2.

Next, the container body 11 is pulled toward the rear end, and the first
The volume of the first space 117 is increased by sliding the gasket 12 inside the container body 11. Thereby, the infusion 107 in the infusion bag 105 is introduced into the first space 117 via the same route as described above. At this time, when the first gasket 12 slides in the container body 11, a predetermined resistance is applied when the protrusion 13 exceeds the protrusion 112 of the container body 11, so that the first gasket 12 is erroneously removed from the container body 11. Extraction is prevented.

Next, in the same manner as described above, the container 10D is shaken or vibrated to dissolve or disperse the drug 152 in the infusion introduced into the first space 117 to obtain a drug solution containing the active ingredient of the drug 152. .

Next, the above operations [3] to [5] are performed.
Here, when the operation [5] is performed, the side hole 211 of the needle tube 21 is
Is inserted into the space 17, and the fitting projections 26a are fitted into the corresponding fitting holes 26b, so that the two gaskets 12, 19 are connected and integrated.

Next, the container body 11 is pressed in the distal direction, and the container body 11 is further inserted into the outer cylinder 2 to reduce the volume of the second space 118.

Next, the container body 11 is pulled to the rear end side, and the connected and integrated gaskets 12 and 19 are connected to the container body 1.
1 to increase the volume of the second space 118. As a result, the infusion 107 in the infusion bag 105 is introduced into the second space 118 via the same route as described above.

Next, in the same manner as described above, the container 10D is shaken or vibrated to dissolve or disperse the drug 153 in the infusion introduced into the second space 118 to obtain a drug solution containing the active ingredient of the drug 153. . Thereafter, the same operation as in the above [6] to [8] is performed.

In the syringe of the present invention, the container may be any of the above-mentioned ones, or may be in any form, such as when the form (liquid, solid) and pressure of the medicine in the first space 117 and the second space 118 are different. Even if they are used, they can be appropriately replaced and used for the syringe body 1B.

The above-mentioned compounding (injection) of the drug
The operation is not limited to the infusion bag 105, and may be performed on a bag for storing a liquid other than the infusion such as a physiological saline solution or a dialysate, blood, plasma, or the like. Further, it can be used for administration of a drug solution to a living body such as intravenous injection, arterial injection, and subcutaneous injection.

FIG. 12 is a longitudinal sectional view showing another configuration example of the container according to the present invention, and FIG. 13 is a bottom view of the container shown in FIG. The container shown in these figures has a ring-shaped rib 115 formed on the outer periphery of the rear end (bottom) of the container main body 11, and is fixedly attached to the bottom of the container main body 11 by engaging with this rib 115. Gripping member (container moving aid) 30
have. The gripping member 30 has an engaging portion 300 that engages with the rib 115 and a flange 301 formed on the opposite side of the engaging portion 300.

In such a container, the operation of moving the container with respect to the syringe main body is performed while holding the flange 301 of the gripping member 30 with a finger or the like. Therefore, the operation, particularly, the direction in which the container is pulled out from the syringe main body (rear end direction). Can be easily and reliably performed. This is particularly effective when the length of the container body 11 is relatively short.

The shape and structure of the gripping member are not limited to those shown in FIGS. Further, in the illustrated configuration example, the container body 11 and the gripping member 30 are configured as separate members, but they may be integrally formed.

FIG. 14, FIG. 15, FIG. 16 and FIG.
It is a longitudinal section showing another example of composition of a syringe main part in the present invention, respectively. Syringe bodies 1C, 1D shown in these
1E and 1E do not have the needle tube 3 in the syringe body 1B, and are liquid-tight so that the lumen 41 of the tube body 4 and the inside of the bag 103 communicate with the bag 103 in which the syringe body itself has flexibility. It is fixed to. Less than,
It will be described sequentially. For convenience of explanation, the upper side in FIGS. 14 to 17 is referred to as a front end, and the lower side is referred to as a rear end.

The syringe body 1C shown in FIG. 14 has the same configuration as the syringe body 1B except that the syringe body 1C does not have the needle tube 3 and the cap 9. A rear end portion of a bag (infusion bag) 103 formed by sealing an edge portion by fusing (for example, heat fusing or high frequency fusing) or bonding to form a bag is fixed in a liquid-tight manner. As a result, the distal end surface 43 of the tubular body 4 is
And the inside of the bag 103 and the lumen 41 communicate with each other.

The bag 103 contains, for example, 5
The infusion 107 of about 0 to 2000 ml is contained.

The syringe main body 1C and the bag 103 are joined by fusing or sealing the distal end of the outer cylinder 2 between the two sheet materials at the sheet material sealing portion 104 formed on the rear end edge of the bag 103. This is done by bonding.

Examples of the sheet material constituting the bag 103 include soft polyvinyl chloride, polyethylene, polypropylene, polyester, ethylene-vinyl acetate copolymer, polyamide, polyurethane, and polyester.
Examples include various elastomers such as polyamide-based, olefin-based, and styrene-based elastomers, and those made of a flexible material such as a mixture thereof.

In the syringe body shown in FIG. 15, the vicinity of the rear end of the outer cylinder 2 is sealed at the rear end of the bag 103 so that almost the whole of the same syringe body 1C protrudes inside the bag 103. 104 is a liquid-tightly fixed configuration. In the present invention, the syringe main body 1C can be fixed to the seal portion 104 of the bag 103 at an arbitrary position on the way from the front end to the rear end of the outer cylinder 2.

The syringe main body 1D shown in FIG. 16 does not have the outer cylinder 2, but has a configuration in which the distal end of the tube 4 is fixed in a liquid-tight manner at the sealing portion 104 at the rear end of the bag 103. Is the same as that of the syringe body 1C. In addition, the tube 4 and the bag 103 in this syringe body 1D
Is formed by fusing or bonding the distal end portion of the tube 4 between the two sheet materials of the seal portion 104.

In the syringe of the present invention, since the needle tube 16 is installed in the first gasket 12, that is, on the container side, even if the outer cylinder 2 is omitted like the syringe body 1D,
There is no danger that the needle tube is exposed at the rear end side of the tube body 4 to cause danger.

The syringe body 1E shown in FIG. 17 has the same structure as that of the syringe body 1C, except that the structure of the sealing means for sealing the lumen 41 of the tube 4 so as to be openable is different. That is, in the syringe main body 1E, the above-mentioned membrane 7 is not provided, and the flexible tube 51 connected to the distal end of the tube 41 and the inside of the tube 51 are sealed so as to seal the flow path in the tube 51. And a sealing member 50 fitted in a liquid-tight manner.

[0138] The sealing member 52 is formed of a cylindrical body whose front end is closed by a solid columnar portion 53, and a thin and brittle breaking portion 54 is formed on the outer periphery thereof. The tip of the tube 51 is pinched from the outside of the bag 103 with fingers or the like,
The solid columnar portion 53 is bent together with the tube 51 to form a broken portion 5.
By breaking the column 4 and separating the solid columnar portion 53, the flow path can be opened. The tube 51 has a function of preventing a sharp edge portion generated by the breakage from damaging the sheet material of the bag 103 when the solid columnar portion 53 is broken and separated.

Examples of the constituent material of the sealing member 52 include hard resins such as polyester such as hard polyvinyl chloride, polycarbonate, and polyethylene terephthalate. As such a sealing member 52, a click chip manufactured by Terumo Corporation can be used.

Further, as a constituent material of the tube 51,
Examples thereof include soft resins such as soft polyvinyl chloride, polyethylene, and polypropylene, silicone rubber, and various elastomers such as urethane, polyester, polyamide, olefin, and styrene, and mixtures thereof.

In the syringe main body 1E, the separated solid columnar portion 53 comes out of the tube 51 and
Means for preventing falling into the inside 3 may be provided. As an example of this means, a configuration in which a ring (not shown) having an inner diameter smaller than the outer diameter of the solid columnar portion 53 is fitted into the distal end of the tube 51 as a stopper of the separated solid columnar portion 53, for example. No.

In the present invention, the sealing means for removably sealing the lumen 41 of the tubular body 4 is not limited to the above-mentioned membrane 7 and the sealing means 50 which can be opened by breakage.
For example, a member that can be closed with the tube 51 interposed therebetween, or a plug that is detachably fitted to the end of the tube 4 may be used.

The syringe bodies 1C to 1E are put in the bag 10
3 is not limited to the rear edge of the bag 103 as shown, but may be the edge of the front end or side edge.
Alternatively, it may be the front or back in FIGS.

FIGS. 18 and 19 are longitudinal sectional views showing still another configuration example of the syringe body according to the present invention. The syringe main body 1F shown in these figures has the same configuration as the syringe main body 1C, such that the inner cavity 41 of the tube 4 and the inside of the bag communicate with the bag whose syringe main body itself has flexibility. It is fixed in a liquid-tight manner. Hereinafter, description will be made sequentially. For convenience of explanation, FIG.
19, the upper side is referred to as a front end, and the lower side is referred to as a rear end.

The bag to which the syringe main body 1F is fixed is a conventional infusion bag 20 containing an infusion 107.
0. The infusion bag 200 is formed by sealing and cutting both ends of a cylindrical resin sheet material similar to the above-mentioned resin material by fusion (for example, heat fusion, high frequency fusion) or adhesion. A hole 202 for hanging the infusion bag 200 by hanging it on a hook or the like is formed at a central portion in the bag width direction of the seal portion 201 on the side, and a central portion in the bag width direction of the seal portion 203 on the rear end side. , Infusion 107
Outlet 204 is formed.

In the syringe body 1F shown in FIG. 18, the infusion is performed by fusing or bonding the distal end portion (opening 2b side) of the outer cylinder 2 between the two sheet materials in the seal portion 201 on the distal end side of the infusion bag. It is fixed to the bag 200 in a liquid-tight manner. In this case, almost the entirety of the syringe main body 1F protrudes inside the infusion bag 200.

In the syringe body 1F shown in FIG. 19, the distal end (bottom 2a side) of the outer cylinder 2 is fused or bonded at the seal 203 on the rear end side of the infusion bag between the two sheet materials. Thereby, it is liquid-tightly fixed to the infusion bag 200. In this case, almost the entirety of the syringe main body 1F protrudes outside the infusion bag 200.

It is to be noted that, unlike the illustration, in the seal portion 201 on the distal end side of the infusion bag, almost the entirety of the syringe main body 1F protrudes outside the infusion bag 200, and in the seal portion 203 on the rear end side of the infusion bag, the syringe Main body 1F
May be configured such that almost the entirety protrudes inside the infusion bag 200.

The syringe main body fixed to the infusion bag 200 may have the same configuration as the syringe main body 1D or 1E. In this case, the syringe body 1
Since D does not have the outer cylinder 2, one end of the tube body 4 is fixed at the seal portion 201 or 203 so that substantially the entirety of the syringe main body 1 </ b> D projects outside the infusion bag 200.

In the configuration shown in FIGS. 18 and 19, the syringe of the present invention can be combined with the existing infusion bag 200, which is easy to manufacture, and has both the use and functions of the existing infusion bag and the like. There is an advantage that can be.

FIG. 20 is a partial longitudinal sectional view showing still another configuration example of the syringe body according to the present invention. For convenience of description, the upper side in FIG. 20 is referred to as a front end, and the lower side is referred to as a rear end. The syringe main body 1G shown in FIG.
The rear end of the tube 70 is liquid-tightly fixed to the rear end of the same bag (infusion bag) 103 as described above. Thus, the inside of the tube 70 communicates with the inside of the bag 103.

The tube 70 and the bag 103 are joined together at the sealing portion 104 of the sheet formed at the rear end of the bag 103 by sandwiching the leading end of the tube 70 between the two sheets. It is done by attaching or bonding.

The rear end (bottom) of the tube 70 is connected to the needle tube 1
The thin film 71 is sealed by a thin film 71 that can be pierced by a plug 6, and a plug 72 is provided on the rear end side of the thin film 71.
This plug 72 is formed by an annular cap (stop) 73.
The tube 70 is pressed and fixed so as to be in close contact with the rear end surface.

The stopper 72 can be pierced by the needle tube 16 and self-occludes after puncturing, that is, the pierced needle tube 1
After the 6 is removed, it is closed by itself to maintain liquid tightness, and the same material as the first gasket 12 or the like can be used as a constituent material.

The tube 70 and the thin film 71 may be made of, for example, polyvinyl chloride, polyethylene, polypropylene, ionomer, polyester such as polyethylene terephthalate, polystyrene, poly- (4-methylpentene-1), polyamide and the like. Of various resins.

The tube 70 may have a structure without the thin film 71. In addition, the distal end of the tube 70 is connected to the bag 10 via a flexible tube (not shown).
3 may be connected.

[0157] For the syringe body 1G having such a configuration, the distal end of the needle tube 16 is connected to the distal end surface 1 of the first gasket 12.
A container similar to the above-described container 10A is used except that it protrudes by a predetermined length from 21. That is, as shown in FIG.
Piercing the tip of the needle tube 16 through the plug 72 and the thin film 71,
The side hole 161 is located inside the tube 70. As a result, the first space 117 of the container has the small holes 171, the space 17,
It communicates with the inside of the bag 103 through the lumen of the needle tube 16, the side hole 161 and the inside of the tube 70. In this state, the container main body 11 is pressed and moved in the distal direction, and the drug solution 150 in the first space 117 is injected into the bag 103 and mixed with the infusion 107. Thereafter, the injection of the chemical solution 151 in the second space 118 is performed in the same manner as described above. In addition, this syringe body 1G
Is the injection of the infusion 107 into the bag 103 or the bag 1
It can also be used as a port for discharging the infusion 107 from the port 03.

In the present invention, a plurality of syringe bodies 1C to 1G having the same or different configurations may be provided for one bag 103 or infusion bag 200. In this case, for example, the syringe body 1C, 1D,
When any two or more of 1E and 1G are provided, each of the seal portions 201 and 203 has a syringe main body 1D to
1F, the outlet 2 of the seal portion 203 is provided when any of the syringe bodies 1D to 1F is provided on both sides of the hole 202 of the seal portion 201, respectively.
For example, a case where any one of the syringe main bodies 1D to 1F is provided on both sides of the cartridge 04 is provided.

Although the syringe according to the present invention has been described with respect to each configuration example shown in the attached drawings, the present invention is not limited to these. For example, the configuration of the connecting portion and the locking portion is not limited to the configuration including the convex portion and the concave portion as illustrated, and the configuration in which the locking and the releasing are performed by relatively rotating these components. And the surfaces to be joined to each other.

The number of gaskets in the container body 11 is not limited to two as shown, but may be three or more. Further, the configuration of the connecting portion and the locking portion is not limited to the configuration as illustrated, and may be, for example, an arbitrary lock mechanism.

[0161]

As described above, according to the syringe of the present invention, for example, injection of a liquid into a bag or compounding of a drug can be performed in a short time by a simple operation. Since a plurality of drugs can be compounded in one container by a simple operation, it is advantageous to respond to an emergency.

[0162] Regardless of the form (liquid or solid) of the drug in the container, it can be compounded by a simple operation. Further, when compounding a plurality of medicines, medicines are stored in each space of the container in a predetermined combination and amount set in advance, so that there is no mixing mistake. In addition, during operation such as compounding of a drug, there is very little chance that various parts of the syringe such as the inside of the container come into contact with the outside air, so that bacterial contamination and contamination of foreign matter can be prevented.

In the syringe of the present invention, the needle tube for communicating with the tube is provided on the first gasket or the like of the container. Therefore, the structure of the syringe body can be simplified by omitting the outer cylinder. It is possible and easy to manufacture. Also, the gasket on the opening side of the container body can be reciprocated in the container body by locking the locking portion and the connecting portion, or two adjacent gaskets are connected and integrated by fitting the fitting portion. And
When these gaskets can be reciprocated in the container body, the medicine in the container can be discharged without waste.

[Brief description of the drawings]

FIG. 1 is a longitudinal sectional view showing a configuration example of a syringe body according to the present invention.

FIG. 2 is a view taken along the line II-II in FIG.

FIG. 3 is a longitudinal sectional view showing a configuration example of a container in the present invention.

FIG. 4 is a longitudinal sectional view showing another configuration example of the syringe body according to the present invention.

FIG. 5 is a longitudinal sectional view showing another configuration example of the container in the present invention.

FIG. 6 is a longitudinal sectional view showing a usage state of the syringe of the present invention.

FIG. 7 is a longitudinal sectional view showing a use state of the syringe of the present invention.

FIG. 8 is a longitudinal sectional view showing another configuration example of the container according to the present invention.

FIG. 9 is a longitudinal sectional view showing another configuration example of the container according to the present invention.

FIG. 10 is a longitudinal sectional view showing another configuration example of the container in the present invention.

FIG. 11 is a longitudinal sectional view showing another configuration example of the container according to the present invention.

FIG. 12 is a longitudinal sectional view showing another configuration example of the container according to the present invention.

FIG. 13 is a bottom view of the container shown in FIG.

FIG. 14 is a longitudinal sectional view showing another configuration example of the syringe body according to the present invention.

FIG. 15 is a longitudinal sectional view showing another configuration example of the syringe body according to the present invention.

FIG. 16 is a longitudinal sectional view showing another configuration example of the syringe body according to the present invention.

FIG. 17 is a longitudinal sectional view showing another configuration example of the syringe body according to the present invention.

FIG. 18 is a longitudinal sectional view showing another configuration example of the syringe body according to the present invention.

FIG. 19 is a longitudinal sectional view showing another configuration example of the syringe body according to the present invention.

FIG. 20 is a longitudinal sectional view showing another configuration example of the syringe body according to the present invention.

[Explanation of symbols]

DESCRIPTION OF SYMBOLS 100 Syringe 1A, 1B, 1C, 1D, 1E, 1F, 1G Syringe main body 2 Outer cylinder 2a Bottom part 2b Rear end opening 2c Flange 3 Needle tube 31 Side hole 4 Tube 41 Lumen 42 Large diameter part 5 Space 6A, 6B Connecting part 61 Male thread 7 Membrane 8 Film 81 Tab 9 Cap 10A, 10B, 10C, 10D, 10E, 10F Container 11 Container main body 111 Tip opening 112 Projection 113 Bottom inner surface 114 Projection 115 Rib 117 First space 118 Second space 12 Gasket 121 Tip surface 122 Rear end surface 123 Outer peripheral surface 13 Projection 14A, 14B Locking portion 141 Bottom surface 15 Internal thread 16 Needle tube 161 Side hole 162 Flange 17 Space 171 Small hole 172 Space 18 Enclosure member 19 Gasket 191 Front surface 192 Rear end surface 193 Surface 20 Protrusion 21 Needle tube 211 Side hole 212 Flange Reference Signs List 22 space 23 recess 24 covering member 25 film 26a fitting protrusion 26b fitting hole 27 annular member 27a fitting protrusion 27b fitting groove 28 needle tube 281 side hole 29 film 291 space 292 passage 30 gripping member 300 engaging portion 301, 302 Flange 303 Shaft 304 Concave part 50 Sealing means 51 Tube 52 Sealing member 53 Solid columnar part 54 Break part 70 Tube 71 Thin film 72 Plug 73 Cap 103 Bag 104 Seal part 105 Infusion bag 106 Elastic stopper 107 Infusion 150, 151 Chemical liquid 152, 153 Drug 200 Infusion bag 201 Seal part 202 Hole 203 Seal part 204 Outlet

──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-6-254166 (JP, A) JP-A-6-54907 (JP, A) JP-A-3-168154 (JP, A) JP-A-48-48 16489 (JP, A) Japanese Utility Model Hei 5-152 (JP, U) Table 6 6-506841 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61M 5/31 A61M 5 / 178 A61M 39/00

Claims (20)

(57) [Claims] 1. A syringe main body having a tubular body, and at least one container connectable to one end of the tubular body, wherein the container has a bottomed cylindrical container body and the inside of the container body. A plurality of gaskets arranged to partition into a plurality of spaces, which can slide in a liquid-tight manner along the inner surface of the container body;
The gasket comprises at least a needle tube installed in the gasket on the opening side of the container main body, and the container main body is formed in a state where the lumen of the tube and the space communicate with each other via the needle tube. By moving the gasket relative to the syringe body in the axial direction and sliding the gasket in the container body, at least a substance in the space is discharged through the needle tube and the tube body. Syringe. 2. The syringe according to claim 1, further comprising means for communicating adjacent spaces among the plurality of spaces. 3. The syringe according to claim 1, wherein each of the gaskets has a needle tube. 4. The syringe according to claim 1, wherein the syringe main body has another needle tube on the distal end side of the tubular body. 5. The syringe body according to claim 1, wherein the syringe body is liquid-tightly fixed to a flexible bag so that the lumen of the tube and the inside of the bag can communicate with each other. A syringe according to claim 1. 6. The syringe body is provided on an outer periphery of the tubular body,
The syringe according to any one of claims 1 to 5, further comprising an outer cylinder into which the container can be inserted. 7. The syringe according to claim 6, further comprising a film for sealing an opening on a rear end side of the outer cylinder. 8. The syringe according to claim 1, wherein the syringe body has sealing means for sealing the inner cavity of the tube so as to be openable. 9. The syringe according to claim 8, wherein the sealing means is a membrane provided on a rear end side of the tubular body and penetrable by a needle tube provided on the gasket. 10. The container according to claim 1, further comprising a connecting portion provided at a rear end side of the tubular body, and a gasket on an opening side of the container body having a locking portion for locking the connecting portion. Syringe. 11. The syringe according to claim 10, wherein the gasket can be reciprocated within the container body by locking the connecting portion and the locking portion. 12. The connecting portion and the locking portion are configured to lock and release them by relatively rotating them.
2. The syringe according to 1. 13. The syringe according to claim 1, further comprising regulating means for regulating an axial position of the gasket with respect to the container body. 14. The gasket according to claim 1, further comprising a fitting portion in which adjacent gaskets in the container main body are fitted with each other, and by fitting of the fitting portion, both gaskets slide integrally.
4. The syringe according to any one of 3. 15. A wrapping member for wrapping a needle tube set in the gasket and pierceable by the needle tube.
15. The syringe according to any one of items 14 to 14. 16. The syringe according to claim 1, further comprising a film for sealing an opening of the container body. 17. The syringe according to claim 1, wherein the substance in each space is a solid or liquid drug. 18. The syringe according to claim 1, wherein a substance having a different component is stored in each of the at least two spaces. 19. The syringe according to claim 1, wherein the inside of the container is in a reduced pressure state. 20. The gasket on the opening side of the container body is provided with a needle tube having needle tips at both ends, and a gasket adjacent to the needle tube is formed with a film that can be pierced by the needle tube. 20. The syringe according to any one of 1 to 19.