JPH06505510A - ９−（β−Ｄ−キシロフラノシル）アデニンおよび１−（β−Ｄ−キシロフラノシル）シトシンの誘導体、それらの調製および治療薬への応用 - Google Patents

９−（β−Ｄ−キシロフラノシル）アデニンおよび１−（β−Ｄ−キシロフラノシル）シトシンの誘導体、それらの調製および治療薬への応用

Info

Publication number
JPH06505510A
JPH06505510A JP5510676A JP51067693A JPH06505510A JP H06505510 A JPH06505510 A JP H06505510A JP 5510676 A JP5510676 A JP 5510676A JP 51067693 A JP51067693 A JP 51067693A JP H06505510 A JPH06505510 A JP H06505510A
Authority
JP
Japan
Prior art keywords
adenine
group
acetyl
xylofuranosyl
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5510676A
Other languages
English (en)
Japanese (ja)
Inventor
アンバッシュ，ジャン−ルイ
ゴスラン，ジル
Original Assignee
サントル、ナショナール、ド、ラ、ルシェルシュ、シアンティフィク、（セーエヌエルエス）
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by サントル、ナショナール、ド、ラ、ルシェルシュ、シアンティフィク、（セーエヌエルエス） filed Critical サントル、ナショナール、ド、ラ、ルシェルシュ、シアンティフィク、（セーエヌエルエス）
Publication of JPH06505510A publication Critical patent/JPH06505510A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP5510676A 1991-12-12 1992-12-14 ９−（β−Ｄ−キシロフラノシル）アデニンおよび１−（β−Ｄ−キシロフラノシル）シトシンの誘導体、それらの調製および治療薬への応用 Pending JPH06505510A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9115420A FR2684997A1 (fr) 1991-12-12 1991-12-12 Derives de la 9-(beta-d-xylofurannosyl) adenine et de la 1-(beta-d-xylofurannosyl) cytosine, leur preparation et leur application en therapeutique.
FR91/15420 1991-12-12
PCT/FR1992/001182 WO1993012128A1 (fr) 1991-12-12 1992-12-14 DERIVES DE LA 9-(β-D-XYLOFURANNOSYL) ADENINE ET DE LA 1-(β-D-XYLOFURANNOSYL)CYTOSINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Publications (1)

Publication Number Publication Date
JPH06505510A true JPH06505510A (ja) 1994-06-23

Family

ID=9419960

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5510676A Pending JPH06505510A (ja) 1991-12-12 1992-12-14 ９−（β−Ｄ−キシロフラノシル）アデニンおよび１−（β−Ｄ−キシロフラノシル）シトシンの誘導体、それらの調製および治療薬への応用

Country Status (5)

Country Link
EP (1) EP0572644A1 (fr)
JP (1) JPH06505510A (fr)
CA (1) CA2103884A1 (fr)
FR (1) FR2684997A1 (fr)
WO (1) WO1993012128A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06321784A (ja) * 1993-03-18 1994-11-22 Nippon Chemiphar Co Ltd 抗ヒト免疫不全ウイルス剤
WO1995007086A1 (fr) 1993-09-10 1995-03-16 Emory University Nucleosides a activite contre le virus de l'hepatite b
US20020120130A1 (en) 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
CA2171518A1 (fr) * 1995-03-24 1996-09-25 Douglas Patton Kjell Methode de preparation de 2,2'-anhydro- et 2' -ceto-1-(3',5'-di-o-protege-.beta.-d-arabinofuranosyl)nucleosides
WO1996040164A1 (fr) 1995-06-07 1996-12-19 Emory University Nucleosides ayant une activite anti-virus de l'hepatite b
DE10110355A1 (de) 2001-03-03 2002-09-12 Ulrich Walker Bekämpfung von Nebenwirkungen
AP2014007796A0 (en) 2011-12-22 2014-07-31 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR6164M (fr) * 1966-10-13 1968-07-08
DE2105560A1 (de) * 1971-02-06 1972-09-07 Boehringer Mannheim Gmbh, 6800 Mannheim Purinribonucleosid-Derivate und Verfahren zur Herstellung derselben
FR2528311B1 (fr) * 1982-06-14 1985-06-14 Synthelabo Compositions pharmaceutiques a base de xylosides et lyxosides de bases puriques et pyrimidiques
DK524588A (da) * 1987-09-22 1989-03-23 Warner Lambert Co Middel til behandling af aids
SE8704298D0 (sv) * 1987-11-03 1987-11-03 Astra Ab Compounds for use in therapy

Also Published As

Publication number Publication date
EP0572644A1 (fr) 1993-12-08
CA2103884A1 (fr) 1993-06-13
FR2684997A1 (fr) 1993-06-18
WO1993012128A1 (fr) 1993-06-24

Similar Documents

Publication Publication Date Title
AU733684B2 (en) 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
US5360795A (en) Polysubstituted benzimidazoles as antiviral agents
US5962684A (en) Method of preparation of dideoxycarbocyclic nucleosides
WO2005090349A1 (fr) Derive de 2-haloadénosine 4'-c substitue
IE812140L (en) Ring open nucleoside analogues
JPH069680A (ja) ２’−フルオロ−２’，３’−ジデオキシピリミジンヌクレオシド
PT86356B (pt) Processo para a preparacao de compostos nucleosidos de pirimidina anti-virais e de composicoes farmaceuticas que os contem
JPH06505510A (ja) ９−（β−Ｄ−キシロフラノシル）アデニンおよび１−（β−Ｄ−キシロフラノシル）シトシンの誘導体、それらの調製および治療薬への応用
US4048432A (en) 9-(3,5-Di-O-acyl-β-D-arabinofuranosyl)adenine compounds and method for their production
JPH01153697A (ja) 治療用ヌクレオシド類
JPH0427966B2 (fr)
JPH04300892A (ja) パートリシン誘導体
US4055717A (en) 9-(3-O-Acyl-β-D-arabinofuranosyl)adenine compounds, 9-(2,3-di-O-acyl-β-D-arabinofuranosyl)-adenine compounds, and method for their production
JPH0546358B2 (fr)
JPH07502740A (ja) 治療用ヌクレオシド
PT90816B (pt) Processo para a preparacao de composicoes farmaceuticas contendo analogos de 2',5'-oligoadenilato
KR880000094B1 (ko) 뉴클레오시드 유도체의 제조방법
JPS58225097A (ja) ヌクレオシド５′−アルキルもしくはアルケニルりん酸
Holmes et al. ESR spectra of free radicals induced in nucleic acid purine and pyrimidine bases and selected analogues by exposure to hydrogen atoms
CA1067072A (fr) COMPOSES DE LA 9-(5-O-ACYL-.beta.-D-ARABINOFURANOSYL) ADENINE ET METHODE POUR SA PREPARATION
JPH01246297A (ja) ベータ―２’，２’―ジフルオロヌクレオシド類の製造方法
US4374831A (en) Modulators of the complement system comprising bis-glucopyranosyl arylene sulfate derivatives
US4393055A (en) Hydroxyalkyl ether derivatives of rutin poly(H-)sulfate and method of use
IE51332B1 (en) Novel adenine nucleoside derivatives,their preparation and pharmaceutical compositions containing them
JPH04501867A (ja) 抗ウィルス剤としての５´―アルキルホスホニルヌクレオシド