JPH06502988A - ポータブルリボザイムカセット、それを含有するｄｎａ配列、これらｄｎａ配列によりコードされるリボザイム、およびこれらリボザイムを含有する組成物 - Google Patents

ポータブルリボザイムカセット、それを含有するｄｎａ配列、これらｄｎａ配列によりコードされるリボザイム、およびこれらリボザイムを含有する組成物

Info

Publication number
JPH06502988A
JPH06502988A JP3512748A JP51274891A JPH06502988A JP H06502988 A JPH06502988 A JP H06502988A JP 3512748 A JP3512748 A JP 3512748A JP 51274891 A JP51274891 A JP 51274891A JP H06502988 A JPH06502988 A JP H06502988A
Authority
JP
Japan
Prior art keywords
ribozyme
sequence
dna
cassette
rna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3512748A
Other languages
English (en)
Japanese (ja)
Inventor
タブラー，マーティン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JPH06502988A publication Critical patent/JPH06502988A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
JP3512748A 1990-07-26 1991-07-26 ポータブルリボザイムカセット、それを含有するｄｎａ配列、これらｄｎａ配列によりコードされるリボザイム、およびこれらリボザイムを含有する組成物 Pending JPH06502988A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP90114359.4 1990-07-26
EP90114359 1990-07-26
PCT/EP1991/001403 WO1992001786A1 (fr) 1990-07-26 1991-07-26 Cassettes de ribozymes portables, sequences d'adn les contenant, ribozymes codes par ces sequences d'adn, et compositions contenant ces ribozymes

Publications (1)

Publication Number Publication Date
JPH06502988A true JPH06502988A (ja) 1994-04-07

Family

ID=8204262

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3512748A Pending JPH06502988A (ja) 1990-07-26 1991-07-26 ポータブルリボザイムカセット、それを含有するｄｎａ配列、これらｄｎａ配列によりコードされるリボザイム、およびこれらリボザイムを含有する組成物

Country Status (5)

Country Link
EP (1) EP0558490A1 (fr)
JP (1) JPH06502988A (fr)
AU (1) AU8294291A (fr)
CA (1) CA2088154A1 (fr)
WO (1) WO1992001786A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU650032B2 (en) * 1990-06-19 1994-06-09 Gene Shears Pty. Limited Endonucleases
US6469158B1 (en) 1992-05-14 2002-10-22 Ribozyme Pharmaceuticals, Incorporated Synthesis, deprotection, analysis and purification of RNA and ribozymes
EP0642589A4 (fr) * 1992-05-11 1997-05-21 Ribozyme Pharm Inc Procede et reactif d'inhibition de la replication virale.
US6017756A (en) * 1992-05-14 2000-01-25 Ribozyme Pharmaceuticals, Inc. Method and reagent for inhibiting hepatitis B virus replication
US5804683A (en) * 1992-05-14 1998-09-08 Ribozyme Pharmaceuticals, Inc. Deprotection of RNA with alkylamine
US6258585B1 (en) 1992-05-14 2001-07-10 Ribozyme Pharmaceuticals, Inc. Method and reagent for inhibiting influenza virus replication
US5610054A (en) * 1992-05-14 1997-03-11 Ribozyme Pharmaceuticals, Inc. Enzymatic RNA molecule targeted against Hepatitis C virus
US5972699A (en) 1992-05-14 1999-10-26 Ribozyme Pharmaceuticals, Inc. Method and reagent for inhibiting herpes simplex virus replication
WO1994000012A1 (fr) * 1992-06-29 1994-01-06 Gene Shears Pty. Ltd. Acides nucleiques et leurs procedes d'utilisation dans la lutte contre des agents pathogenes de nature virale
US5891684A (en) * 1992-10-15 1999-04-06 Ribozyme Pharmaceuticals, Inc. Base-modified enzymatic nucleic acid
EP0707638A4 (fr) * 1992-12-04 1998-05-20 Innovir Lab Inc Acide nucleique regulable a usage therapeutique et procedes d'utilisation associes
FR2701960B1 (fr) * 1993-02-26 2002-09-13 Gene Shears Pty Ltd Polyribozyme apte à conférer, aux plantes, une résistance aux virus et plantes résistantes produisant ce polyribozyme.
WO1995010608A1 (fr) * 1993-10-15 1995-04-20 Foundation For Research And Technology - Hellas (Fo.R.T.H.) Ribozymes asymetriques en tete de marteau et sequences de nucleotides destinees a leur construction
AU687479B2 (en) 1993-11-08 1998-02-26 Ribozyme Pharmaceuticals, Inc. Base-modified enzymatic nucleic acid
US5834440A (en) * 1994-03-07 1998-11-10 Immusol Incorporated Ribozyme therapy for the inhibition of restenosis
US5942395A (en) * 1997-05-09 1999-08-24 Universite De Montreal Hybrid ribozymes and methods of use
WO1999032618A1 (fr) * 1997-12-19 1999-07-01 Strata Biosciences Incorporated Clonage non bacterien pour l'apport et l'expression d'acides nucleiques
CA2319112C (fr) 1998-02-13 2003-10-28 Genetrace Systems, Inc. Utilisation de ribozymes afin d'identifier la fonction de genes
DE10337407A1 (de) * 2003-08-13 2005-03-10 Transmit Technologietransfer Klonierungssystem

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO114469B1 (ro) * 1987-12-15 1999-04-30 Gene Shears Pty Ltd Compus oligoribonucleotidic, procedeu de preparare si metoda de inactivare
DE3935473A1 (de) * 1989-10-25 1991-05-02 Hoechst Ag Rna mit endonuclease- und antisense-aktivitaet, ihre herstellung und ihre verwendung

Also Published As

Publication number Publication date
EP0558490A1 (fr) 1993-09-08
CA2088154A1 (fr) 1992-01-27
WO1992001786A1 (fr) 1992-02-06
AU8294291A (en) 1992-02-18

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