CA2088154A1 - Cassettes de ribozymes, sequences d'adn les contenant, ribozymes codes par ces sequences d'adn et compositions contenant ces ribozymes - Google Patents

Cassettes de ribozymes, sequences d'adn les contenant, ribozymes codes par ces sequences d'adn et compositions contenant ces ribozymes

Info

Publication number
CA2088154A1
CA2088154A1 CA002088154A CA2088154A CA2088154A1 CA 2088154 A1 CA2088154 A1 CA 2088154A1 CA 002088154 A CA002088154 A CA 002088154A CA 2088154 A CA2088154 A CA 2088154A CA 2088154 A1 CA2088154 A1 CA 2088154A1
Authority
CA
Canada
Prior art keywords
ribozyme
dna
rna
sequence
cassette
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002088154A
Other languages
English (en)
Inventor
Martin Tabler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Foundation For Research And Technology - Hellas (forth) Institute Of Molecular Biology & Biotechnology
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2088154A1 publication Critical patent/CA2088154A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
CA002088154A 1990-07-26 1991-07-26 Cassettes de ribozymes, sequences d'adn les contenant, ribozymes codes par ces sequences d'adn et compositions contenant ces ribozymes Abandoned CA2088154A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90114359 1990-07-26
EP90114359.4 1990-07-26

Publications (1)

Publication Number Publication Date
CA2088154A1 true CA2088154A1 (fr) 1992-01-27

Family

ID=8204262

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002088154A Abandoned CA2088154A1 (fr) 1990-07-26 1991-07-26 Cassettes de ribozymes, sequences d'adn les contenant, ribozymes codes par ces sequences d'adn et compositions contenant ces ribozymes

Country Status (5)

Country Link
EP (1) EP0558490A1 (fr)
JP (1) JPH06502988A (fr)
AU (1) AU8294291A (fr)
CA (1) CA2088154A1 (fr)
WO (1) WO1992001786A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU650032B2 (en) * 1990-06-19 1994-06-09 Gene Shears Pty. Limited Endonucleases
WO1993023569A1 (fr) * 1992-05-11 1993-11-25 Ribozyme Pharmaceuticals, Inc. Procede et reactif d'inhibition de la replication virale
US6469158B1 (en) 1992-05-14 2002-10-22 Ribozyme Pharmaceuticals, Incorporated Synthesis, deprotection, analysis and purification of RNA and ribozymes
US5610054A (en) * 1992-05-14 1997-03-11 Ribozyme Pharmaceuticals, Inc. Enzymatic RNA molecule targeted against Hepatitis C virus
US6258585B1 (en) 1992-05-14 2001-07-10 Ribozyme Pharmaceuticals, Inc. Method and reagent for inhibiting influenza virus replication
US6017756A (en) * 1992-05-14 2000-01-25 Ribozyme Pharmaceuticals, Inc. Method and reagent for inhibiting hepatitis B virus replication
US5804683A (en) * 1992-05-14 1998-09-08 Ribozyme Pharmaceuticals, Inc. Deprotection of RNA with alkylamine
US5972699A (en) 1992-05-14 1999-10-26 Ribozyme Pharmaceuticals, Inc. Method and reagent for inhibiting herpes simplex virus replication
HUT71929A (en) * 1992-06-29 1996-02-28 Gene Shears Pty Ltd Nucleic acids and methods of use thereof for controlling viral pathogens
US5891684A (en) * 1992-10-15 1999-04-06 Ribozyme Pharmaceuticals, Inc. Base-modified enzymatic nucleic acid
EP0707638A4 (fr) * 1992-12-04 1998-05-20 Innovir Lab Inc Acide nucleique regulable a usage therapeutique et procedes d'utilisation associes
FR2701960B1 (fr) * 1993-02-26 2002-09-13 Gene Shears Pty Ltd Polyribozyme apte à conférer, aux plantes, une résistance aux virus et plantes résistantes produisant ce polyribozyme.
WO1995010608A1 (fr) * 1993-10-15 1995-04-20 Foundation For Research And Technology - Hellas (Fo.R.T.H.) Ribozymes asymetriques en tete de marteau et sequences de nucleotides destinees a leur construction
EP0728204A1 (fr) 1993-11-08 1996-08-28 Ribozyme Pharmaceuticals, Inc. Acide nucleique enzymatique a modification de base
US5834440A (en) * 1994-03-07 1998-11-10 Immusol Incorporated Ribozyme therapy for the inhibition of restenosis
US5942395A (en) * 1997-05-09 1999-08-24 Universite De Montreal Hybrid ribozymes and methods of use
EP1037972B1 (fr) * 1997-12-19 2005-09-14 HK Pharmaceuticals, Inc. Clonage non bacterien pour l'apport et l'expression d'acides nucleiques
DE69933856D1 (de) 1998-02-13 2006-12-14 Koester Hubert Verwendung von ribozymen zur bestimmung der funktion von genen
DE10337407A1 (de) * 2003-08-13 2005-03-10 Transmit Technologietransfer Klonierungssystem

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO114469B1 (ro) * 1987-12-15 1999-04-30 Gene Shears Pty Ltd Compus oligoribonucleotidic, procedeu de preparare si metoda de inactivare
DE3935473A1 (de) * 1989-10-25 1991-05-02 Hoechst Ag Rna mit endonuclease- und antisense-aktivitaet, ihre herstellung und ihre verwendung

Also Published As

Publication number Publication date
AU8294291A (en) 1992-02-18
WO1992001786A1 (fr) 1992-02-06
JPH06502988A (ja) 1994-04-07
EP0558490A1 (fr) 1993-09-08

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Legal Events

Date Code Title Description
FZDE Dead